Updated: 11/17/2015 - Sponsored by Leptigen

Applied Nutrition Synergy 21 Lipo-Burner Review - Does This Diet Product Actually Work? Are fad supplement ingredients and dieter complaints deal breakers?

Editor's Review: 3.5 / 5.0

applied-nutrition-synergy-21-product-imageI’m here to cut through the noise and get you the bottom line on Applied Nutrition Synergy 21 Lipo-Burner. Here at DietSpotlight, we did one of our detailed reviews, examining the ingredients, side effects, customer-service quality and scientific research. Furthermore, we focused on numerous user comments and customer reviews from around the web. At last, we summed up all of the facts and feedback we discovered to give you the important info you need.

EDITOR'S TIP: Substitute Applied Nutrition Synergy 21 Lipo-Burner with a proven fat burner such as Leptigen for better results.

What You Need To Know

Applied Nutrition Synergy 21 Lipo-Burner is touted as a thermogenic fat burner and metabolizer. It’s directed to be used twice a day, 30 minutes before breakfast and lunch. Both women and men can take this supplement for weight loss purposes. As for the ingredients in Applied Nutrition Synergy 21 Lipo-Burner, they include the following; Chromium, Green Tea, Hoodia Powder, Natural Caffeine, Acai Berry, Brown Kelp Powder, Glucomannan, Green Coffee Bean Extract, Raspberry Ketones, White Kidney Bean Extract, Yerba Mate Leaf, African Mango Seed, Caralluma Fimbriata, Resveratrol, Cayenne Fruit, Mulberry Fruit, Lychee Extract, Garcinia Cambogia Extract, Apple Cider Vinegar, Grapefruit Extract and Prickly Pear Leaf.

We are not sure when Applied Nutrition Synergy 21 Lipo-Burner first emerged. However, we do know that this product contains plenty of natural ingredients and it’s easy to find online, but read on…

Fad Supplement Ingredients – Concerning?

According to our Research Editor, “Applied Nutrition Synergy 21 Lipo-Burner contains fad supplement ingredients such as Hoodia Powder and Raspberry Ketones, which are not backed by any solid science or clinical research.”

“Did not help me with weight loss at all. Not sure if this stuff works as claimed,” said one dieter.

Another person commented, “No weight loss! Give me a break! This pill is not legit!”

Scroll below for one of the best products we’ve seen in 2015.

Dieter Complaints – Another Issue

We found a number of user complaints posted online for Applied Nutrition Synergy 21 Lipo-Burner. In fact, one customer stated, “This gave me a terrible stomachache. I won’t use it again.”

“Causes some side effects. Had a headache and abdominal discomfort. Must not be right for me,” said another user.

The research we’ve conducted has proven that if there is a particular aspect of a diet program or supplement that is especially annoying or bothersome (fad supplement ingredients, dieter complaints, high cost) the likelihood of prolonged weight loss success is slim. Therefore if Applied Nutrition Synergy 21 Lipo-Burner does in fact result in a high number of dieter complaints, this could be a big problem.

So What About Actual Science?

There is no clinical research presented with Applied Nutrition Synergy 21 Lipo-Burner to support the claimed effectiveness of this product. Therefore it’s impossible to know how well this supplement actually works for weight reduction. We at DietSpotlight need to see some documented science that backs up the product’s weight loss claims.

The Bottom Line: Does Applied Nutrition Synergy 21 Lipo-Burner Work?

So, should you run out and buy Applied Nutrition Synergy 21 Lipo-Burner? Well, we appreciate that this supplement contains some natural ingredients and it’s easy to use anywhere. On the other hand, we have some reservations about this diet product because it’s not supported by any solid science. Furthermore, we’re concerned about the fad supplement ingredients it contains and the numerous dieter complaints we found posted on the internet.

If you’d like to drop more weight, then we suggest you try a product that does not contain any fad supplement ingredients, is backed by solid clinical research and is supported by all kinds of positive user reviews.

Among the best products we’ve seen in 2015 is one called Leptigen. This product contains four powerful ingredients, which have been proven in documented clinical research to help enhance fat loss and elevate metabolism. You should also know that we can’t find any talk of harmful side effects and dieter comments posted online indicate people are seeing solid results.

The makers of Leptigen are so excited about their product they’re offering a Special Trial Offer, which is very reassuring.

Learn More About Leptigen »
GD Star Rating

How Does Applied Nutrition Synergy 21 Lipo-Burner Compare?

Previous Applied Nutrition Synergy 21 Lipo-Burner Review (Updated August 14, 2012):

What You Should Know

Click Here To See Our Highest Rated Review

Since losing weight is tough, you should not overlook weight loss supplements. More and more of these fat-fighting products are being released every year. The right diet pill could be what you need to kick start your weight loss program. We are now going to take a look at Applied Nutrition Synergy 21 Lipo-Burner. This supplement is taken twice each day, 30 minutes before meals (two tablets is a serving). It contains all sorts of ingredients to aid with weight management.


  • Chromium as Chromium Picolinate 100mcg
  • Lipo-Burner Blend 775mg
  • Green Tea Extract (50% EGCG)(Leaf)
  • Hoodia Powder (Aerial Stem)
  • Natural Caffeine
  • Acai Powder (Berry)
  • Brown Kelp Powder (Seaweed)
  • Glucomannan
  • Green Coffee Bean Extract (10% Chlorogenic Acid) (Fruit)
  • Raspberry Ketones
  • White Kidney Bean Extract (20:1)(Seed)
  • Yerbe Mate Powder (Leaf)
  • African Mango (Irvingia Gabosensis) Powder (Seed)
  • Caralluma Fimbriata Extract (21:1)(Plant)
  • Grapefruit Extract (4:1)(Seed)
  • Prickly Pear Powder (Leaf)
  • Apple Cider Vinegar Powder (Fruit)
  • Garcinia (Garcinia Cambogia) Extract (50% HCA) (Fruit)
  • Lychee Extract (10%) (Seed)
  • Mulberry Extract (10:1) (Fruit)
  • Cayenne (30,000 SHU) Powder (Fruit)
  • Resveratrol Extract (8%) (Root Rhizome)
  • Microcrystalline Cellulose
  • Dibasic Calcium Phosphate
  • Croscarmellose Sodium
  • Stearic Acid
  • Magnesium Stearate
  • Silicon Dioxide
  • Sodium Carboxymethylcellulose
  • Dextrose
  • Soy Lecithin
  • Sodium Citrate
  • Dextrin

Product Features

Applied Nutrition Synergy 21 Lipo-Burner is available for $14.99 (60 tablets). This supplement is meant to be taken in conjunction with a low-calorie diet plan and regular exercise. According to the manufacturer, this product contains 21 of the best weight loss ingredients on the market at this point. It helps with weight reduction by increasing the metabolism, promoting overall health, regulating blood sugar levels, suppressing appetite, providing antioxidants, increasing energy levels, reducing body fat, and assisting with digestive function.

Some key ingredients used in Applied Nutrition Synergy 21 Lipo-Burner are Chromium, Hoodia Gordonii, Green Tea Extract, Caffeine, Glucomannan, Lychee Extract, Apple Cider Vinegar Powder, Raspberry Ketones, Green Coffee Bean Extract, Yerba Mate, Garcinia Cambogia, and White Kidney Bean Extract.

See Our Featured


  • This weight loss supplement contains antioxidants.
  • Applied Nutrition Synergy 21 Lipo-Burner contains Green Tea Extract.


  • It is recommended to avoid caffeine when taking this supplement.
  • Some users might experience jitteriness, nausea, headache, rapid heartbeat, and sleeplessness.
  • This supplement might cause your blood pressure to increase.
  • This supplement contains high levels of caffeine.
  • We were unable to find customer testimonials for Applied Nutrition Synergy 21 Lipo-Burner.


While most weight loss products contain a few key ingredients to encourage weight reduction, Applied Nutrition Synergy 21 Lipo-Burner has included 21 of them, which is a lot. While this sounds promising, it may be a tad too extreme on the body. After all, you are not supposed to consume foods and beverages containing caffeine, while you are taking this diet product. In other words, Applied Nutrition Synergy 21 Lipo-Burner contains a lot of caffeine, and may cause some side effects like sleeplessness, jitters, rapid heartbeat, headache, and anxiety.

7 User Reviews About Applied Nutrition Synergy 21 Lipo-Burner

Leave comments below
  • 1

    I want to try it. But need to know… is it shellfish free?


    Your Name

    No its not shellfish free


  • 2

    My first time trying it tonight im gonna work out an give my input if i see see results in a week thanks


  • 3

    not sure, just started today. But I’d really appreciate it if someone could tell me how long till I see results with exercise and diet? and what should I expect?



    I’m wondering did you see any results Tim. I just brought this product today and started it.


    Jae Hudson

    I have been using this product on and off now for a year. I have lost 55 pounds within 5 months with a semi raw diet. I do not work out…..I just don’t have time, but suggest it. I get typical results within 3-5 days, I start to feel my stomach and butt reducing. I love this! I have a thyroid disorder and I do not get jitters or feel any side effects and I am a coffee drinker about 3-5 cups some days. I also follow a gluten free diet, mainly eating all the fruit I want. Hope this helps:)



    Hi, I just bought the product today so I will.start tomorrow..
    How is it working for you so far?


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