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Calotren Review - Does This Weight-Loss Supplement Really Work? Are lack of clinical results and negative customer reviews deal breakers?

By Summer Banks on Oct 14, 2016
Calotren Review

Why are people talking about Calotren? We wanted to know more, so we created a detailed review, examining the ingredients, side effects, customer-service quality and scientific research. Furthermore, we focused on hundreds of dieter comments and user reviews found on the web. At this point we summarized the info we found to give you the bottom line.


What is Calotren?

Firstly, Calotren is a weight-loss supplement. The ingredients are collagen hydrolate, ProHydrolase and vitamins. Take four capsules at bedtime with eight ounces of water and supposedly helps your body burn off sugars and fat. One benefit is that healthy eating is encouraged.

Top of the World Distributors released Calotren in 2010. The company was founded in 1997. You can buy the product on the official website and through trusted retailers. This supplement doesn’t contain any stimulants and no special diet is required, but read on…

No Real Clinical Evidence – “A Problem?”

Our first concern with Calotren ingredients is a lack of clinical support.“There is no actual evidence presented on the formula regarding weight-loss or fat reduction,” said our Research Editor. “While this supplement may help with protein absorption, this could be why some customers didn’t see results.”

One user said, “I tried Calotren for a month and received no results. Worked out, cut back food in-take and didn’t eat after 7pm every night. Didn’t feel any different health wise either.”

Another stated, “Well it don’t work for my wife, and she’s not very happy about this product. I think she gained weight instead of losing.”

Negative Customer Reviews – “Not Good”

While we were able to find a few customer testimonials posted online for Calotren, there are also negative user reviews. One dieter said, “If you are at all sensitive to taking pills, don’t do this! I followed the instructions, waited the 3 hours after eating before taking it, and then barely slept all night. It says “no stimulants” but something kept me awake and feeling sick all night.”

“I tried Calotren for three months. Did not loose any weight. It was a waste of my money. Would not recommend it to anyone,” claims a buyer

Our research has proven if a specific part of a weight-loss product or diet formula is especially problematic (a painful/difficult exercise routine, no clinical research, too many customer complaints) the likelihood of real success, for the long run, is slim. If Calotren does in fact fail to produce results and leads to bad reactions, as reported by some customers, this could be a major issue.

The Science – “Nothing Available?”

There is no scientific research presented on the official website for Calotren and we didn’t find any either. For us at DietSpotlight, we need to see documented clinical support for the supplement and its ingredients. While this product is claimed to produce great results, there is simply no real evidence to support fat loss or weight management.

The Bottom Line – Does Calotren Work?

Let’s take a closer look at our results, shall we? Calotren is an interesting weight management supplement and it does contain some intriguing ingredients. However, we can’t recommend this diet product because there is no published clinical data to support this formula. Furthermore, Calotren is quite pricey at $69.95 per bottle. Not to mention, there are no customer testimonials posted on the official website at all.

For dieters who need to slim down and shed pounds more quickly, we suggest you to go with a weight-loss supplement that is both affordable and backed by real scientific studies and supportive customer reviews.

Among the best products we’ve seen in 2016 is one called Leptigen. This diet pill contains a proprietary blend of four ingredients, which have been proven in documented clinical studies to increase fat loss and ignite metabolism. Also, we were unable to find any negative feedback about harmful side effects and customer reviews posted online show people are seeing great results.

Plus, the producers of Leptigen are confident enough in their product to offer a Special Trial Offer, a good sign.

Get Your Sample Today »
About the Author:

Summer Banks is an ISSA-Certified Fitness Nutrition Specialist and has reviewed over 2000 diet products. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

How Does Calotren Compare?

Previous Calotren Review (Updated February 6, 2014):

What You Should Know

The weight loss product Calotren is a protein supplement manufactured and distributed by Top of the World Distributors. Calotren seems to claim to be a metabolic supplement that is suitable for both overweight users and users looking to improve their metabolic health. Interestingly, Calotren seems to come in both liquid and capsule form. A 30-day supply of the supplement retails from the manufacturer for approximately $65.00, making it a moderately expensive regimen to maintain. Instructions for Calotren use indicate that a full course of the supplement is intended to last 90 days, yielding weight loss and a more toned physique. Both the liquid and capsule forms of Calotren are protein-based formulations. The product contains no ephedra or caffeine, both of which have been found to over-stimulate the metabolism and potentially cause rapid heart-rate and "jitters." The official product website goes out of its way to point out that Calotren does not "stimulate, starve or trick" your body. While that does sound appealing, the further product claims are a bit ambiguous, implying that Calotren acts as a "support" for the body's natural fat burning cycle, while also boosting stamina in non-overweight users. This ambiguity, both as to the product's applications and its active ingredients, strikes us as a bit off. The mysterious Calotren protein also claims to benefit wrinkled skin.

List of Ingredients

The active ingredients of liquid Calotren are: Oxygenated water, Collagen Hydrolysate (Bovine Source), Aloe Vera, Glycerin, Potassium Sorbate, Natural Raspberry Flavoring, Methyl Paraben. The active ingredients in capsule Calotren are: Collagen Hydrolysate (Bovine or Marine Source - your choice), Aloe Vera, Vegetable Glycerin. Inactive ingredients in both forms of the product: Gelatin, Magnesium Stearate, Stearic Acid and Microcrystalline Cellulose.

Product Features

Calotren is intended to be taken once per day. Take either a single tablespoon or four pills of Calotren in the evening before going to sleep. For most effective results, do not eat anything three hours prior to taking the product and, if taking the pills, use only a glass of water to wash them down. This is so that your body can begin using the Calotren while you sleep. Top of the World Distributors also claim that taking Calotren in the morning or before exercising will give users increased energy.

See Our Featured


  • Full ingredient list for product featured on official website.
  • Product is available from manufacturer online.
  • Product does not contain caffeine or ephedrine.


  • No free gift or multi-bottle purchase offered on official website.
  • Product claims are very broad, making it sound like an all-around "miracle" supplement. We'd prefer a product that focuses specifically on weight loss.
  • No product trials or development info offered on official website.
  • Reading the ingredient list, we see no proprietary ingredients that separate this product from others.
  • No free sample.


While we certainly appreciate that Calotren does not contain caffeine or other potentially harmful stimulants, we're not really impressed by what it does contain. We are also weary of any product that claims to help with weight loss, boost energy and clear up wrinkles, all in one package. We'd love to believe in Calotren, but the official website offers no user testimonials or before-and-after photos. With so many proprietary products on the market for the same price, we'd hold out for something that can offer more sophisticated lab research and an approach that is specifically targeted towards weight loss.

Calotren Questions & Answers:

We refined hundreds of user comments about Calotren into this helpful FAQ.

What are the side effects of Calotren?

Some potential side effects of Calotren include stomach discomfort, cramps, gassiness, nausea and diarrhea.

What are the ingredients in Calotren?

Calotren ingredients are filtered water, collagen hydrolysate, aloe vera, vegetable glycerin, natural and artificial raspberry flavor, potassium sorbate, citric acid and sodium benzoate.

Does Calotren work?

The official website provides information about the benefits of protein and digestive enzymes. We found that there’s no scientific research connecting Calotren to weight-loss or improved health and wellness.

How much does Calotren cost?

Calotren costs $69.95 for the liquid or capsules. If you purchase two bottles, you’ll pay$104.93 and $189 for three.

How should I take Calotren?

You should take Calotren a minimum of three hours prior to sleep. You take one teaspoon or four capsules with water. The company recommends taking the supplement for 90 days.

Can I take Calotren if I have a health condition?

If you are under 18 years of age, have health conditions, take prescription medication or a woman whose pregnant or nursing, you should consult with a physician prior to using any weight-loss supplement, including Calotren.

What do users like about Calotren?

Some dieters liked that Calotren was reasonably priced and that it’s available in a variety of locations.

What do users NOT like about Calotren?

We found that some users didn’t like that Calotren didn’t work and that the supplement caused side effects.

How do I contact the Calotren customer service department?

You can contact the Calotren customer service department by calling 1-800-325-4366, using the customer feedback form on the website or sending correspondence to the corporate team at Top of the World Distributors 100 N. First St. Union City, TN 38261.

Can I contact Calotren through social media?

Yes, you can contact Calotren through Facebook and Twitter.

What can I drink before taking Calotren?

You can drink water before taking Calotren.

How much protein is in a serving of Calotren?

Each serving contains 3g of protein.

Do I need to diet on Calotren?

No, you don’t need to diet on Calotren, but the company recommends eating healthy to maximize results.

Why do I need to take Calotren at night?

You take Calotren at night because the majority of food consumed is digested.

What is the source of protein in Calotren?

The source of protein comes from beef and marine foods.

Is there a guarantee with Calotren?

Calotren offers a 45-day money-back guarantee. You can return purchased items for a 100% refund. This policy doesn’t apply to items received a free gifts. You are charged a $10 restocking fee.

Do you know of any special deals or discounts on Calotren?

The special deals mentioned on the official website are free shipping with a minimum purchase and a cost savings when you buy more than three bottles of Calotren.

Calotren Side Effects:

Even natural weight-loss supplements have the ability to cause negative reactions. There’s no such thing as a 100% issue-free formula. Calotren side effects are very rare, but that doesn’t mean they aren’t very real for some users.


When air gets into your digestive tract it may cause gassiness. The gas will pass throughout your mouth as a burp or out as flatulence. Gas usually comes with bloating and sometimes comes with a stomachache.

What causes gassiness?

Gassiness may be caused by swallowing air during eating or drinking. It may also be caused by the food you eat or it could come as an allergic reaction to medication or a supplement.


A red, swollen mark found on the skin is known as a welt. They show up as bumps on the skin with fluid buildup directly below the surface. [1]

What causes welts?

Welts on the skin may be caused by an injury or strike to the skin. They are also commonly caused by an allergic reaction to medication, food or supplements.


Any type of pain felt in the head may be known as a headache. There are several different types of headaches and they all feel different. For example, a tension headache may be felt behind the eyes and might feel very tight, while a migraine may cause you to feel like you cannot move and may come with sensitivity to light.

What causes headaches?

Headaches are caused by a number of factors. Some people suffer from headaches due to an illness or something they ate. Others will experience headaches during a sudden weather change. They can also be caused by an allergy to medication.


An involuntary contraction of any muscle is known as a cramp. Usually, this involuntary contraction comes along with quite a bit of pain. A muscle cramp may also be known as a charley horse or a muscle spasm.

What causes cramps?

Cramps may be caused by a number of things including dehydration, muscle fatigue, poor blood circulation, overexertion, calcium deficiency, potassium deficiency or even a reaction to medication. [2] Athletes usually suffer from muscle cramps when performing in the heat or without proper stretching.


Loose stool coming out very fast during a bowel movement is known as diarrhea. It usually comes along with a sick or nauseous feeling in the stomach.

What causes diarrhea?

A number of different things may cause diarrhea from food poisoning to the stomach flu. Its most often caused by a bacteria or viral infection, but may also be caused by a more serious disease or as a reaction to a drug or supplement.

It’s not a guarantee that you will suffer from Calotren side effects, such as gassiness, welts, headaches, cramps, diarrhea and others. In order to protect yourself from any negative reactions, consult with a physician before taking any weight-loss supplement, especially if you’re pregnant or nursing, under the age of 18, suffer from a medical condition or you’re taking a prescription medication of some sort.



Calotren is a weight-loss supplement that uses Callagen and Prohydrolase. Though we found only a few mentions of side effects, these are worth noting.


“Barely slept all night…something kept me awake and feeling sick all night.”    Anjee


“I started getting raised welts on my face and chest.”    Carrolyn


“Well it didn’t work for my wife…I think she gain weight instead of losing it.”    Stacy


“Calotren makes me gag, I CANNOT take that liquid.”    Dana


“I took the product for approx 2 weeks when I suffered the worst episode of gout ever…”    Rodney


“I notice every time I take this supplement I have a serious headache.”    Katherine

Calotren is a weight-loss supplement from Top of the World Distributors. According to the official website, customers have reported decreased joint pain, improved sleep and increased energy. There is a liquid and a capsule with the program. The ingredient lists don't show anything with strong clinical support, in terms of weight-loss.

Calotren Ingredients and Supplement Facts

Serving Size: 1 TBSP or 4 Capsules
Serving Per Container: 30
Amount per Serving % DV
Calotren Advanced Capsules * *
- Collagen Hydrolysate * *
- ProHydrolase * *
- Aloe Vera Leaf Extract * *
Calotren Liquid * *
- Collagen Hydrolysate * *
- Aloe Vera * *

Other Ingredients: May include: filtered water, gelatin, vegetable magensium stearate, vegetable glycerin, natural and artificial raspberry flavor, potassium sorbate, citric acid, sodium benzoate

We examined the Calotren ingredients in order to give you the facts you need.

Collagen Hydrolysate

Collagen hydrolysate is an amino acid, in which high amounts of glycine, lysine, and proline, which are not often found in other protwin supplements.

What Is It Supposed To Do?

Collagen hydrolysate is often used as an extra nutritional aspect in dietary supplements.

Clinical Research

According to a study published in Current Medical Research and Opinion, “e results of this study have implications for the use of collagen hydrolysate to support joint health and possibly reduce the risk of joint deterioration in a high-risk group. Despite the study’s size and limitations, the results suggest that athletes consuming collagen hydrolysate can reduce parameters (such as pain) that have a negative impact on athletic performance.” However, nothing was said connecting it to weight-loss.

Aloe Vera

Aloe vera is a plant composed primarily of water. However, it contains many minerals that can be beneficial to the body.

What Is It Supposed To Do?

Aloe vera has many benefits to the body, including aiding in digestion, fighting disease, and helping the immune system.

Clinical Research

In an article published in Herbal Medicine: Biomolecular and Clinical Aspects: 2nd Edition, “Despite its long history of use, there remains a lack of consistent scientific evidence to support many of the therapeutic claims for Aloe vera.”

Filtered Water

Filtered water is just regular water that has been pushed through a filter, where it becomes cleaner.

What Is It Supposed To Do?

Though water is generally essential for any life, filtered water can prove to have some benefits, including activated carbon, aeration, cation exchange, distillation, reverse osmosis, and UV disinfection.

Clinical Research

In a study published in Nutrition Reviews, “Both studies reported more rapid weight loss among pre-meal water drinkers.” This does not count for supplement because this study was conducted with the consumption of water before meals.

Vegetable Glycerin

Vegetable glycerin is a clear liquid that has a sweet taste. It is used commercially for cosmetics and food.

What Is It Supposed To Do?

Vegetable glycerin is used for solvents, sweeteners, antifreeze, soaps, cosmetics, and more.

Clinical Research

In a study published in Metabolism: Clinical and Experimental, researchers noted, “Glycerol [another name for vegetable glycerin] did not differ from an equicaloric dose of glucose in its effect on hunger ratings, diet compliance or overall weight loss. We conclude that oral glycerol is not a useful adjunct to weight reduction programs.”

26 User Reviews About Calotren

Leave comments below
  • 1
    Linda C

    I have taken this diligently for just over a year now. Exactly like I`m supposed to. Even did 3 rounds of Probiotics purchased thru same company as suggested. To date, I have not lost 1 single pound. Nor any inches. Nothing whatsoever. Very, very disappointing. I tried so seriously. Hoping.


  • 2

    i have been using it for 3 months does not work no weight loss no better rest will not recommend to anyone


    Karen (Editor)

    Hi Rick, you might want to look into a more proven fat burner like leptigen. Click here to try it out.


  • 3
    Laura Edwards

    I am over 50 female and interested in this product due to Bob Cole radio testimony… However, my belly fat weight gain is largely due to hormonal non-production stage of life. Does this product work while going through this temporary transition?


    Stephen (Editor)

    Hi, Laura. It is highly recommended that you consult your doctor before taking this or any dietary supplement.


  • 4

    I plan on ordering the product. I think results are different for everyone. At least this what I am seeing on reviews. I can tell you though as a certified herbalist, your body will not do what it is supposed to do if you are full of yeast or have untreated hypothyroidism. So to those of you whose reviews are negative you might want to check yourself for candida and have your hormone levels checked before trying any weight loss product.


  • 5
    Gail Eiceman

    I am a nurse specialist and a board certified clinical nutritionist.
    I am always looking for products to help with weight loss.Could you please email any information that would be helpful and how many carbohydrates are in a serving.
    thank you,
    Gail Eiceman RN,BS,CCN


  • 6
    Cindy N

    My husband and I both started Calotren right after Thanksgiving 2014…not yet reached 60 days. He has lost a little weight. I have not really seen any weight loss but have been able to move down from size 18-20 to my size 16 pants already. Can’t wait to see how things continue if things normally take at least 90 days for any real results as the instructions say. We have not changed anything at all about our routine or meals. Oh we are both 56 years old and remaining optimistic.


  • 7
    Lisa Dantin

    I started Calotren on 10/16/13, I have taken it nightly for 109 days. I started losing inches after about the second bottle I was on. I am now on bottle 4 and have lost one pant size and 10.2 lbs. I do believe you start to see the best results after your 90 days. I had been having trouble with both of my legs hurting at night after doing a complete split while mopping my closet in Auguest 2012…I would turn from side to side all night long with shooting, stabbing pin-like pain in both legs…I can honestly say the pain is now gone, and I sleep so much better now. I am on NO diet, and eat whatever I want…please give it at least 90 days to see results…it is awesome, and I will continue to take it!


  • 8
    Your Name

    why would these people continue to use the product and pay for the product from months with no results… BS is what i say


  • 9
    Sarah McDonald

    Never lost a pound, but after ripping my rotator cuff in my shoulder, it worked wonders at healing it. Also, as an older woman approaching menopause, it helped me to sleep through hot flashes better.


  • 10

    I was given 3 bottles of calotrin but i can’t find an expiration date on the bottles; where is it located and how old can the product be used safely?


  • 11

    Calotren works but it does take a while. You must be diligent in taking each night. It was not until the 13th week that I noticed my clothes were loose when usually tight and at that moment became a believer in the product and continue to use. Patience is definitely the key here. Thanks Calotren!


  • 12

    Two months and haven’t lost a pound and have followed what they said, 4 pills with water at bedtime and no food 3 to 4 hours before.


  • 13

    I’m going to go out on a limb and say that Calotren – just like any other weight loss program – works differently on different people. I’m just sayin’ – I mean anyone with any sense knows that not everything works on everybody the same way. Thanks!


  • 14

    I have been taking Calotren for over a year now. The first month of use I didn’t notice any change in weight loss, the second month, I dropped an entire pant size. I’m not a heavy person, size 10 and I dropped to a good size 8 (my clothes fit really good, not to tight and not to baggy). I had no change in my diet. Nor did I drink water with taking the pill and still had success.


  • 15

    I’ve tried Calotren for a month and although I eat a healthy, low fat calorie diet averaging between 800 and 1000 calories a day, I haven’t lost any weight at all. I feel it was a waste of my money.



    unless you are a ” little person ” you should be eating at least 1200 caleries a day so your body doesn’t go into famine mode and store everything.


  • 16

    I have been taking Calatren noe for 5 month and no weight loss……


  • 17

    I tried Calotren for three months. Did not loose any weight. It was a waste ofmy money. Would not recomend it to anyone.


  • 18
    Debra Abshier

    Hi I want to know if there is no caffeine in this product why when I take it exactly as directed can I not sleep? I take it a 10pm right before going to bed and then I can not go to sleep until 3am I have tried everything to lose wieght and thought since Bama Brown from kase lost 100lbs it must be the best product for me. I tried to take this for 2 weeks with no weight loss and no sleep. hope you can tell me why this product wont allow me to sleep if ther is no caffine. thanks Debra


    Julie Mortenson

    My husband bought 6 bottles for my daughter and myself because Bob Cole at KVET had lost weight on it since I think December. But the thing you don’t hear in the ads is that (it tells you this in the book that comes with it) you’re supposed to give up starches while on it. Well, heck I know I can lose weight if I completely give that up. But they made it sound like you didn’t have to do anything special to lose weight while on this. BTW my daughter and I have not lost hardly anything yet.


    Sara Tanner

    I have never slept better with this product! And it has aided me in losing 20 lbs in the last two months. Other than watching my fat intake and taking Lipozene, I am not actually dieting. I know three people personally that did nothing but take this product and still lost approx. 5-6 lbs per week.



    I sleep great when I take Calotren. I have more energy and therefore I am more active and that might be why I lose weight with it but either way I totally recommend anyone give it a try.


  • 19
    Vickie Tucker

    I have had a stroke. Taking BP meds, meds for high cholesterol, meds for depression is it safe for me to take Calotren?



    I sure as heck hope not, as I am also on many meds due to a heart attack. The only problem I have seen so far is that, and I have been on it for over 60 days, it doesn’t seem to work. Not one pound or one inch have I lost. $200 down the drain.


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