Contrave Review

Editor's Review: 3.5 / 5.0

What You Should Know

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2/2/2011 UPDATE: Today, the FDA rejected Orexigen Therapeutics Inc.’s Contrave pill, citing fears that the pill may increase heart risk. The FDA has not approved a new weight loss medication in ten years. The agency says it will evaluate Contrave again after Orexigen undertakes a costly new study examining possible links to heart risk. A spokesman for Contrave said that the company is evaluating next steps and deciding whether they will go through with the expensive study. Sorry, bad news for everyone who was looking to try this promising new drug.

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12/9/2010 UPDATE: Today, the Endocrine and Metabolic Drugs Advisory Committee, a division of the FDA, has voted to recommend Contrave as a weight loss aid. However, the FDA still has to give the drug final approval before it can be distributed by physicians. The FDA takes sub-panel decisions such as this into consideration before approving any pharmaceutical drug. Like, the FDA will decide on approving Contrave for weight loss in January, 2011. However, the panel also recommends additional cardiovascular studies of patients prior to beginning sales based on case study findings, indicating that this product still may not be suitable for those with heart conditions. We will continue to update our review as more information becomes available.

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Contrave is still in the testing stages, but it seems to offer great promise as a medication that will actually reduce the risk factors associated with obesity. Currently, this drug is in its third stage of clinical trials to assess the “safety, tolerability and efficacy”, according to the company website. The company that is responsible for Contrave is Orexigen Therapeuticals, a biopharmaceutical company that is focused on creating drugs that treat central nervous system disorders, including obesity. Current studies are showing that Contrave can effectively reduce metabolic syndrome in many patients. Metabolic syndrome is a combination of risk factors that may increase the incidence of obesity, which can also increase the risk of heart disease and diabetes. This medication takes a whole new approach to weight loss, by focusing on neurological causes of obesity rather than suppressing appetite or altering metabolic function.

List of Ingredients

The two main ingredients that are being studied in the Contrave formula include Naltrexone and Bupropion. Naltrexone has been used in the United States to treat opioid addiction since 1984, and in 1995 it began to be used to treat alcoholism as well. This drug inhibits the reinforcement of addictive substances by blocking opioid receptors to the brain, according to the Orexigen website. Naltrexone has also been shown to alter the taste of foods in numerous clinical studies.

Bupropion has been used to treat depression since 1985, and in 1997 trials were begun that experimented with the use of Bupropion as an aid to help quit smoking. This drug appears to be effective at suppressing appetite and increasing energy levels, and is the most prescribed antidepressant in the United States at the time of this review. One side effect that has been noted with Bupropion is weight loss; an attractive side effect for many indeed.

Product Features

Since this medication is still in the clinical trial stage, there are few product features to report. It is suspected that this medication will only be available by prescription, since it contains potent ingredients with potentially dangerous side effects. There is no pricing or customer testimonials at this time; however, ample clinical data is provided on the Orexigen website, and this info is comprehensive and professionally displayed.

See Our Featured Diet

Advantages

  • The ingredients in Contrave may be effective in suppressing appetite and promoting weight loss.
  • Many clinical studies have been done on this product and are continuing at this time.
  • The company website contains ample information on the developmental progress of this product.

Disadvantages

  • This product is not yet available to the general public at the time of this review.
  • The ingredients in Contrave may have potentially serious side effects for some.
  • May interact badly with other prescription medications.

Conclusion

Contrave is worth keeping an eye out for, since the initial clinical studies have been promising and plenty of research is being conducted on the product. However, Contrave will not be the right choice for everyone, due to the possible side effects and medication interactions that may occur. Also, it definitely appears that Contrave will be prescription only, and will most likely be used to treat clinical obesity. It is important to talk to your doctor about whether Contrave would be a good choice for you.

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72 User Reviews about Contrave

  • 1
    jonathan bowen

    my dr. prescribed contrave for me and I have been taking it for one month with no adverse side affects. and I am losing weight while on the meds. it does cut your appetite. I don’t even think of eating my wife has to remind me to eat. I think it works wonderfully.

    [Reply]

    Sony

    How are you doing now? I just got prescription and afraid of having seizures and side effects.

    [Reply]

  • 2
    shpresa

    I just want to know if you can get free samples,can I get in on the trials for contrive.

    [Reply]

  • 3
    besa

    Please keep me in mind if you are looking for volunteers to try Contrave. I just want to know if you can get free samples

    [Reply]

  • 4
    krenare

    I just want to know if you can get free samples? and can you tell me where to get the samples.Please keep me in mind if you are looking for volunteers to try Contrave

    [Reply]

  • 5
    jodi

    My Dr. Just prescribed Contrave. I just got home reading thru the material. It says if you have a seizure, stop taking it! I dont know if i should even start, im so scared to have a seizure! Please help!

    [Reply]

  • 6
    kathy

    can I get in on the trials for contrive?

    [Reply]

  • 7
    sherry

    could I please get in on the trials for contrive. please reply. I would like to try it out.

    [Reply]

  • 8
    sherry darwin

    can I get in on the trials for contrive?

    [Reply]

  • 9
    sherry

    I just want to know if you can get free samples? and can you tell me where to get the samples.

    [Reply]

  • 10
    lis

    i would like to try concave .wold like to loose some weight i am not on medications i dont have high blood pressure dont have heart disorders .I do exercise and my thyroid is great dont know y i cannot loose i eat healty and small portions

    [Reply]

  • 11
    Cindy Johnson

    Please keep me in mind if you are looking for volunteers to try Contrave before it hits the market.

    [Reply]

  • 12
    Wade Gushee

    cost and availability

    [Reply]

    Tanya

    Mines is 57 a month ..just got it today …I hope it works

    [Reply]

    Sarah

    Hi I just sent off for mine 2 days ago, how are you doing on yours?

    [Reply]

    laurie

    How is it going so far my Dr just prescribed this for me but have not received it yet

    valsab

    I have started 10 days ago and I’m still fighting side effects (nausea, diarrhea, dizziness mainly). No effect I can see yet but I’m only taking 1+1 right now. How are y’all doing?

    VTobar

    I started two days ago and have felt very Dizzy!!! and throwing up to the point that im in tears…just wondering if your side effects have gone away?

    Patti

    Where did you get contrave for 57 a month? How are you doing on it?

    [Reply]

  • 13
    debbie

    i want to be a trial person for contrave i have diabeties and htn an am obese

    [Reply]

  • 14
    nita hamilton

    i would like to be in the clinical trials

    [Reply]

  • 15
    Mel

    When do we find out if it got approved today or not????

    [Reply]

  • 16
    tkaly

    lmk when contrave will be on market

    [Reply]

  • 17
    John Denny

    Do you have a date when contrave when this will be on the market for Doctor’s can order?

    [Reply]

  • 18
    Anonymous

    can we not order it elsewhere???

    [Reply]

  • 19
    maria

    when contrave will be on the market? also want to know if this med will be for prescription only or ove the counter?

    [Reply]

  • 20
    genny holland

    please let me know when this is approved I would even like to be on your testing sight.

    [Reply]

    joyce

    it s on today but can t find much more still new chack with your Dr, asap

    [Reply]

  • 21
    Renee

    I too was in the study. It was wonderful. I could look at something temping (like cookies, candy ect. and say no thank you.) Trust me, that has never happened in my life! I lost 30 lbs and never gained it back. I still can’t wait for it to come out. I still have a lot of weight to loose.

    [Reply]

  • 22
    Julie Byrd

    I owuld be interested in being a part of the clinical trial also.

    [Reply]

  • 23
    alice

    I am very interested in being part of the clinical trial too but I think it’s too late. So I just want to know when it will be available on the market. Thanx :)

    [Reply]

  • 24
    markakis

    iwould also like to be part of the clinical trial

    [Reply]

  • 25
    Fred Reeves

    interested in being part of trial study

    [Reply]

  • 26
    anita

    please let me know about it. I would like to try Contrave when it becomes available.

    THANKS

    [Reply]

  • 27
    colleen kane

    I want to be in clinical trial.

    [Reply]

  • 28
    mari

    let me know when it come out cuz i try everything and nothing had work…thank you

    [Reply]

  • 29
    Mary

    I am very overweight plus I am 54 years old and need help..I can’t even put socks on when it is cold..My asthma is getting worse I have tried everything now I have no motivation. I can only hope this works. Let me know when it is available ty.I am 120 pounds overweight

    [Reply]

  • 30
    George Jannusch

    Can this be taken if I am on long term warafin, Blood Thinner? I will be on blood thinners all my life. Thank you for your input.
    George Jannusch

    [Reply]

    Kathy Schwab

    I would like to know about Warfarin and this product, along with medication for diabetics, high blood pressure, pain meds for chronic lower back pain, Effexor RX, acid reflux med., and about 180 LBS. needed to lose

    [Reply]

  • 31
    Marsha

    I would also like to be part of the clinical trial.

    [Reply]

  • 32
    suzee

    please email me when i can buy it i am really excited

    [Reply]

  • 33
    Sadie

    Please let me know when this product becomes available to the public, and if insurance will cover it. Thankyou

    [Reply]

  • 34
    joan guerin

    I would be interested in this product when it comes available. Will you let me know by E mail?

    [Reply]

  • 35
    Lisa

    I was in the clinical trial for this, and lost over 40 pounds (started at 171, ended at 130). Unfortunately, when the study was over (I finished in Dec 2008) and it was no longer available to me, I gained it all back plus 10 more pounds. I can’t wait for it to be approved by FDA and made availalbe – I’ll definitely go back to this!

    [Reply]

    besa

    Hi Lisa for hw long did you lose 40 pound

    [Reply]

    Sarah

    Lisa, how long did it take to lose the bulk of your weight

    [Reply]

  • 36
    estela

    Great news ! I would also like to be part of the clinical trial. I used Phen-Phen and lost the weight but gained back when stopped. I am really hoping this product will work for me and be also safe, I am so very tired of being overweight, I am trapped in this big body when inside I’m thin, healthy and happy…

    [Reply]

  • 37
    Debra Straub

    I am almost 51 years old, who has been struggling with obesity all her like. I am very interested in learning more about this new drug “Contrave” and when the availability will be. I would even consider being part of a trial study with this product.

    [Reply]

  • 38
    Richard Lanza

    I would like to try this trial, Im 555 lbs and they wont operayr on me till I losr wait first and Im up all night lomg

    [Reply]

  • 39
    Terri

    Will there be a trial in this area? I would like to volunteer for that. I am obese and have tried numerous things. I am borderline diabetic, starting with high blood pressure, and have been taking heart pills for 3 years. I am 40 years old!!!

    [Reply]

  • 40
    Jennifer

    What is the status on FDA approval and public release?

    [Reply]

  • 41
    cadujovne

    Please give me more details on your ifo about Contrave”May interact badly with other prescription medications”

    [Reply]

  • 42
    Susan

    I would like to know when this product will be available. I would also volunteer to be in a study if you need more people.

    [Reply]

  • 43
    mary

    When will we be able to get the diet pill contrave,I thought it was to be released
    in january 2010 for prescription. Why hasn’t it ?

    [Reply]

  • 44
    Lori Groleau

    When will Contrave be available? I am very interested n finding out if it is right for me.

    [Reply]

  • 45
    Colleen

    When will Contrave be available?

    [Reply]

  • 46
    Marti Huffman

    I was in a study for this drug and am very excited about it becomming available to the public…. any idea on how long that will be???

    [Reply]

  • 47
    lauren

    I would like to be in a clinical study .

    [Reply]

  • 48
    Judy

    I would like to try Contrave when it becomes available.

    [Reply]

  • 49
    James Wade

    I would like to be in clinical study of Contrave, or any other weight loss medication.

    [Reply]

  • 50
    Sharon

    I would like to try it.

    [Reply]

    Geraldine Adams

    When will Contrave be available?

    How does it measure up against
    other diet pills?

    [Reply]

  • 51
    Debbie

    Please let me know when It becomes available. Also I would like to be involved in a clinical trial of this product or any future weight loss products.

    [Reply]

  • 52
    JANICE

    PLEASE LET ME KNOW WHEN AVAILABLE. ALSO I WOULD LIKE TO BE A TRIAL PERSON IF AVAILABLE AND NEEDED FOR FURTHER TESTING. SOUNDS GOOD HAVE TESTED EVERY PRODUCT ON THE MARKET STILL OVER WEIGHT. HELP PLEASE.

    [Reply]

    Tier Atkins

    PLEASE LET ME KNOW IF THEY STILL NEED PEOPLE FOR TRAIL STUDY, I have tryed everything from diet pills to even having my mouth wired close. Please contact asp.

    [Reply]

    Sandee J

    I was on the 52 week trail. I went from 190 to 129 & was advised to gain at least 6 back. shoud be 135 to 140. I am now 180 after being on an antideprssant. I can’t wait until it is approved so I can go back on it. IT WAS GREAT.

    [Reply]

    cindy

    What was the name of the diet pill you used and how did you get ahold of it?

    [Reply]

    mark

    How long was it after taking it that you felt it starting to work , 1 week or 2 weeks ? Please let me know .

    [Reply]

    Sarah

    How long did it take to lose the bulk of your weight

    [Reply]

  • 53
    Wanda

    I am interested in this product. I would like to hear more about it as it is introduced to the public.

    [Reply]

  • 54
    Maggie Zimmerman

    Can I get an e-mail when it becomes available?

    [Reply]

    Pjames

    Please email me when the drug becomes available. I am interested in doing a trial study

    [Reply]