Previous Contrave Review (Updated August 12, 2014):
What You Should Know
2/2/2011 UPDATE: Today, the FDA rejected Orexigen Therapeutics Inc.'s Contrave pill, citing fears that the pill may increase heart risk. The FDA has not approved a new weight loss medication in ten years. The agency says it will evaluate Contrave again after Orexigen undertakes a costly new study examining possible links to heart risk. A spokesman for Contrave said that the company is evaluating next steps and deciding whether they will go through with the expensive study. Sorry, bad news for everyone who was looking to try this promising new drug.
12/9/2010 UPDATE: Today, the Endocrine and Metabolic Drugs Advisory Committee, a division of the FDA, has voted to recommend Contrave as a weight loss aid. However, the FDA still has to give the drug final approval before it can be distributed by physicians. The FDA takes sub-panel decisions such as this into consideration before approving any pharmaceutical drug. Like, the FDA will decide on approving Contrave for weight loss in January, 2011. However, the panel also recommends additional cardiovascular studies of patients prior to beginning sales based on case study findings, indicating that this product still may not be suitable for those with heart conditions. We will continue to update our review as more information becomes available.
Contrave is still in the testing stages, but it seems to offer great promise as a medication that will actually reduce the risk factors associated with obesity. Currently, this drug is in its third stage of clinical trials to assess the "safety, tolerability and efficacy", according to the company website. The company that is responsible for Contrave is Orexigen Therapeuticals, a biopharmaceutical company that is focused on creating drugs that treat central nervous system disorders, including obesity. Current studies are showing that Contrave can effectively reduce metabolic syndrome in many patients. Metabolic syndrome is a combination of risk factors that may increase the incidence of obesity, which can also increase the risk of heart disease and diabetes. This medication takes a whole new approach to weight loss, by focusing on neurological causes of obesity rather than suppressing appetite or altering metabolic function.
List of Ingredients
The two main ingredients that are being studied in the Contrave formula include Naltrexone and Bupropion. Naltrexone has been used in the United States to treat opioid addiction since 1984, and in 1995 it began to be used to treat alcoholism as well. This drug inhibits the reinforcement of addictive substances by blocking opioid receptors to the brain, according to the Orexigen website. Naltrexone has also been shown to alter the taste of foods in numerous clinical studies.
Bupropion has been used to treat depression since 1985, and in 1997 trials were begun that experimented with the use of Bupropion as an aid to help quit smoking. This drug appears to be effective at suppressing appetite and increasing energy levels, and is the most prescribed antidepressant in the United States at the time of this review. One side effect that has been noted with Bupropion is weight loss; an attractive side effect for many indeed.
Since this medication is still in the clinical trial stage, there are few product features to report. It is suspected that this medication will only be available by prescription, since it contains potent ingredients with potentially dangerous side effects. There is no pricing or customer testimonials at this time; however, ample clinical data is provided on the Orexigen website, and this info is comprehensive and professionally displayed.
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- The ingredients in Contrave may be effective in suppressing appetite and promoting weight loss.
- Many clinical studies have been done on this product and are continuing at this time.
- The company website contains ample information on the developmental progress of this product.
- This product is not yet available to the general public at the time of this review.
- The ingredients in Contrave may have potentially serious side effects for some. (See Contrave Side Effects).
- May interact badly with other prescription medications.
Contrave is worth keeping an eye out for, since the initial clinical studies have been promising and plenty of research is being conducted on the product. However, Contrave will not be the right choice for everyone, due to the possible side effects and medication interactions that may occur. Also, it definitely appears that Contrave will be prescription only, and will most likely be used to treat clinical obesity. It is important to talk to your doctor about whether Contrave would be a good choice for you.
Contrave Questions & Answers:
We picked apart hundreds of user comments about Contrave and condensed into this helpful FAQ.
What are the side effects of Contrave?
Some Contrave side effects may include diarrhea, dry mouth, sleeplessness, dizziness, vomiting, headache, constipation and nausea.
What are the ingredients in Contrave?
Contrave are ingredients bupropion hcl, naltrexone hcl, microcrystalline cellulose, hydroxypropyl cellulose, lactose anhydrous, L-cysteine hydrochloride, crospovidone, magnesium stearate, hypromellose, edetate disodium, lactose monohydrate, colloidal silicon dioxide, opadry II blue and fd&c blue #2 and aluminum lake.
Does Contrave work?
There is scientific research into the effectiveness of Contrave as the medication has been FDA-approved, but there are also clinically proven side effects.
How much does Contrave cost?
Contrave costs about $300. The price could change after insurance is factored into the equation.
How should I take Contrave?
You should take one Contrave capsule in the morning the first week, one pill in the morning and another in the evening the second week. On the third week, you will consume two in the morning and one in the evening. The fourth week and beyond, you will take two in the morning and two in the evening. The company recommends not crushing, chewing or cutting the product, as well as not taking the pill with high-fat meals.
Can I take Contrave if I have a health condition?
Women who are pregnant or nursing, those with health conditions of any kind, people under 18 years of age and anyone taking prescription medications should consult with a healthcare professional prior to using a weight-loss medication, including Contrave.
What do users like about Contrave?
Some users liked that Contrave has been approved by the FDA and that they lost weight.
What do users NOT like about Contrave?
We found that some users didn’t like the high price tag of Contrave and the side effects.
How do I contact the Contrave customer service department?
You can contact the Contrave customer service department by mailing correspondence to Takeda Pharmaceuticals One Takeda Pkwy. Deerfield, IL 60015, calling a representative at 1-877-825-3327 or by using the customer feedback form on the official website.
Who uses Contrave?
Individuals that are considered overweight or obese use Contrave. Your BMI has to be more than 27.
Can I stop Contrave on my own?
No, you can’t stop Contrave on your own. You will need to contact your healthcare provider prior to stopping this medication because of the potential for withdraw symptoms.
What should I tell my healthcare provider before taking Contrave?
You should tell your healthcare provider if you have a medical condition, if you are taking prescription medication or if you are pregnant or nursing.
What should I avoid while taking Contrave?
You should avoid using alcohol on Contrave.
Does Contrave come with a guarantee?
There’s no mention of a guarantee with Contrave.
Do you know of any special deals or discounts on Contrave?
There are special deals or discounts on Contrave, if you sign up for the savings card.
Contrave is a prescription weight-loss medication that contains an anti-depressant. It is not unheardof for these drugs to be used for a variety of reasons like weight-loss and smoking cessation. You cannot purchase this formula in stores or online without a prescription.
Contrave Ingredients and Supplement Facts
Serving Size: Varies
Serving Per Container: Varies
|Amount per Serving
We dug deep into the Contrave ingredients to give you the details you need.
Bupropion hydrochloride is a prescription medication that goes by the names of Aplenzin and Wellbutrin XL.
What is it Supposed to Do?
It is used to treat depression and prevent seasonal affective disorder. There are other uses, including the treatment of attention deficit hyperactivity disorder (ADHD), and smoking cessation. It may also be used with other mood stabilizers to treat bipolar disorder, and may be used to treat anxiety in people with depression.
There are a number of clinical studies available on this medicine, because it has been tested for FDA approval. One of the main side effects associated with Bupropion is weight-loss.
This medication is available by prescription only, and may also be marketed under the name Revia. It’s designed to treat opiate addiction, and used as part of a more comprehensive treatment program. The medication may also be used to treat alcohol abuse.
What is it Supposed to Do?
It works in the brain to prevent the affects of opiates – pain relief and feelings of well-being from taking place. It also works to decrease the desire to use opiates.
There are a number of studies on this medication, though none are directly tied to weight-loss. According to a study published in Journal of Clinical Pyschopharmacology, “Although both groups showed decreases in smoking urge scores through treatment, the reductions were larger in the naltrexone group, with an average Brief Questionnaire of Smoking Urge scale score decrease of 13.6 ± 1.17 points in the naltrexone group compared with 9.58 ± 1.39 points in the placebo group (β [SE] = −4.37 [2.05], P < 0.05).”