What You Should Know
LeptiBurn is a weight loss supplement from BioTrust Nutrition. According to Joel, BioTrust Nutrition co-founder, leptin works as the dominant hormone controlling functions of all other weight loss hormones. Increasing leptin production and restoring leptin sensitivity would, in theory, promote weight loss and help dieters break through weight loss plateaus. There is little doubt that leptin is significantly intertwined with appetite and weight control, but can an herbal formula alter leptin levels and leptin sensitivity to promote weight loss?
List of Ingredients
- Olive Leaf Extract
- Brown Seaweed Extract
- Irvingia Gabonensis Extract
- Panax Notoginseng Extract
- Green Tea Extract
- Yerba Mate Extract
BioTrust Nutrition does a fantastic job of breaking down the LeptiBurn formula and supporting how the ingredients promote weight loss with clinical research. There’s even a dedicated page with a long list of clinical references for consumers with questions about the efficacy of the supplement. We decided to do a little research of our own to see if the ingredients in LeptiBurn are as effective as BioTrust Nutrition claims them to be.
Olive leaf extract has some clinical support as an antibiotic, antioxidant and anti-hypertensive, but BioTrust Nutrition focuses on the extract’s ability to stimulate GLP-1 (glucagon peptide-1). We were able to locate a study by Eamon P. Rafferty, et al published in Scientia Pharmaceutica in 2011 supporting this claim. The study reported a 48% increase in plasma GLP-1 in rats given olive leaf extract. GLP-1 is associated with insulin sensitivity and decreased appetite, but ileal cells release GLP-1 when nutrients like carbohydrates, proteins and fats hit the small intestine. LeptiBurn is taken on an empty stomach thus the effects could help signal a feeling of fullness before the morning and afternoon meals essentially reducing the amount of food intake to promote weight loss.
Brown seaweed extract is a good source of fucoxanthin and iodine. Fucoxanthin has been named in numerous clinical studies on weight loss – most of which use rats as the study group – with positive results. Human studies are not as readily available, but we were able to find one study on obese, non-diabetic women with normal liver fat levels and no indication of non-alcoholic fatty liver disease that showed fucoxanthin, when paired with pomegranate seed oil, promoted weight loss. LeptiBurn does not contain pomegranate seed oil. BioTrust Nutrition mentions a study claiming fucoxanthin decreases leptin levels. If LeptiBurn increases leptin levels why add an ingredient that decreases leptin levels?
Irvingia gabonensis is an excellent source of fiber. Fiber is commonly added to weight loss supplements to slow digestion and promote satiety. There is some evidence the seed extract can help lower high cholesterol, but weight loss studies are not as conclusive. BioTrust Nutrition mentions a study that shows irvingia gabonensis increases leptin sensitivity by reducing C-reactive protein. We found the study published in the journal Lipids in Health and Disease. According to the study, participants were given 3,150 mg of irvingia gabonensis extract daily as 1,050 mg three times a day. LeptiBurn supplies just 300 mg of the extract taken as 150 mg twice daily. There is no comparison between the clinical study and the amount of extract supplied by LeptiBurn – there is simply not enough irvingia gabonensis.
Panax Notoginseng, also known as panax pseudoginseng, is not the same as panax ginseng. Clinical animal studies have shown panax notoginseng significantly reduces bleeding time. The extract may also have liver protective qualities. BioTrust Nutrition quotes a study published in the Journal of Ethnopharmacology in 2010 claiming panax notoginseng produces an anti-hyperglycemic effect as a result of improved leptin sensitivity. The study administered 200 mg/kg of panax notoginseng saponins by injection to lab rats genetically prone to diabetes. In a 200-lb human the amount of panax notoginseng required to produce comparable results would be more than 18,000 mg. Saponins are secondary metabolites found in panax notoginseng. Panax notoginseng was not injected as a whole extract.
Green tea extract and yerba mate extract are, in our opinion, the best ingredients in LeptiBurn. Both are clinically supported in human weight loss. Green tea extract is an excellent source of caffeine and EGCG and yerba mate is a source of caffeine. BioTrust Nutrition mentions these ingredients supply caffeine, but the total amount of caffeine supplied is not noted. Dieters sensitive to caffeine may need to exercise caution when taking LeptiBurn or any supplement containing caffeine.
- All ingredients and amounts in LeptiBurn are listed online.
- Green tea and yerba mate may promote metabolism and weight loss.
- Not all studies used to support LeptiBurn were completed on humans.
- The total amount of caffeine supplied per serving is not listed.
BioTrust Nutrition claims LeptiBurn will increase leptin levels, promote leptin sensitivity and help the dieter lose more weight. Clinical evidence for some of the ingredients, from a human perspective, are lacking in some cases. We love the strong dose of green tea extract and the addition of caffeine, but we would like to know just how much caffeine the dieter is taking.