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LipoDerm Review

Editor's Review: 3.2 / 5.0

What You Should Know

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LipoDerm-Ultra, by Avant Labs, is a spray on weight loss supplement that uses spot reduction technology to target fat in areas such as the abdominal region, hips, thighs and buttocks. The key ingredients are Yohimbe HCL and caffeine. Because of the supplement’s topical form, Avant claims the product has no negative side effects. However, spot reduction technology is rather experimental, and there is a large amount of information not given on how the formula really works.


Yohimbe HCl, Caffeine, Octopamine HCl, Sesamin, Synephrine, Acetyl-Carntine, Ascorbyl Palmitate, and Lecithin.

Product Features

Yohimbine does not have thorough scientific studies supporting its benefits in weight loss. Only a few studies suggest that it blocks alpha(2) andrenoreceptors and is especially effective in the abdominal region in men and the glutofemoral area of women. This ingredient is also well known as a sexual stimulant. Avant gives no warning of the possibility that LipoDerm can increase your libido, making it unclear whether those effects would take place. The caffeine in LipoDerm is meant to reduce water retention. A small amount of caffeine is used in the formula, producing no stimulating effects. The fat burner Synephrine is a popular substitute for the illegal ephedrine. This product is feared by some consumers because of its similar structure to ephedrine. Octopamine HCl supposedly acts as a thermogenic agent by targeting fat brown cells. This claim is not backed by scientific evidence and this alkaloid is relatively new to the weight loss industry.

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  • 100% money back guarantee.


  • Should not be used by people with heart or blood pressure problems.
  • Contains caffeine despite its “no-stimulant” promise.
  • Relatively expensive at $25 per small bottle.


Regardless of whether or not this product can be viewed as effective, it comes in a spray bottle. This technology has not been tested thoroughly, making us question whether or not the hydroalcoholic gel could be properly absorbed into the skin. This product is not worth the high price considering it doesn’t contain effective ingredients including appetite suppressors.

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