Updated: 11/24/2015 - Sponsored by Leptigen

Methyldrene Elite Review - Does This Weight-Loss Supplement Work? Are side effects and questionable business practices deal breakers?

Editor's Review: 3.5 / 5.0

methyldrene-elite-product-imageThe results of my research into Methyldrene Elite were somewhat surprising. Here we are with an in-depth review of the product. We covered the ingredients, side effects, clinical study and customer service quality. We also scoured the web for user experiences. With that in mind, we condensed and refined to give you the info you need.

EDITOR'S TIP: Substitute Methyldrene Elite with a proven fat burner such as Leptigen for better results.

What You Need to Know

Firstly, Methyldrene Elite is a fat-burning supplement that uses caffeine, white willow bark, ephedra, ginseng and citrus aurantium. When taken in pill form, Methyldrene Elite claims to provide an intense burst of energy, appetite suppression and fat-burning. You can find it for about $30 from a couple of obscure online retailers, but it is small enough to take on the go.

We couldn’t find any determinate information online about the company, Cloma Pharma, behind Methyldrene Elite and there is no mention of when this supplement was released. The moderate cost and the guaranteed results are certainly positives, but read on…

Side Effects – “Health Concerns?”

The first thing we felt important to note about Methyldrene Elite ingredients was the potential for side effects. “Yes, taking ephedra has been clinically proven to boost energy and metabolism,” says our Research Editor. “Unfortunately, the FDA took it out of the diet market in 2004 because of reported health problems. It is these potential Methyldrene Elite side effects that worry us.”

The National Institute of Health has ephedra listed with “significant safety concerns reported.” Nausea, heart palpitations, anxiety and mood changes are just a few possibilities.

When taken along with caffeine, the chances of side effects are multiplied. One question we do have is whether or not the supplement contains ephedrine, the leading alkaloid and cause for concern in ephedra. We can’t tell from the product descriptions, but dieters may want to steer clear.

Scroll below for one of the best products we’ve seen in 2015.

Legal – “A Serious Concern”

As we mentioned before, ephedra was banned from the diet industry more than 10 years ago. We have no way of knowing if Cloma Pharma uses the real thing in the supplement or just an imitation, but if it’s the real deal they could be held legally responsible for its sale and use.

When we visited Cloma Pharma’s website, everything was shut down except for a recall notice by the FDA for three of their products, including Methyldrene Original. Apparently the company experienced a salicylic acid  contamination in some of their supplements, not a good sign. No other information could be found.

We have found that supplements have to avoid bad side effects and other issues to provide long term success for users. Methyldrene Elite provides nothing but red flags everywhere. The risk of adverse reactions is enough for us to give this one a thumb down.

The Science – “Is It Proven?”

Believe it or not, there is plenty of research into Methyldrene Elite. Caffeine, ephedra and white willow bark combine to make the classic ECA stack. Clinical studies have shown increased metabolism and weight-loss with this formula. But, the dieter must take into account that the FDA banned the main ingredient in 2004 because of serious health issues. At DietSpotlight, we like to see published support, but that’s not enough to counteract the risk in this case.

The Bottom Line – Does Methyldrene Elite Work?

So, the time has come to tell you the final verdict on this one. We are usually suspicious of products that can’t be found on reputable websites and that don’t have many user reviews. All we really know about Methyldrene Elite is that it uses an ECA stack that has caused severe side effects in the past and is now illegal in the diet industry. The company behind it, Cloma Pharma, is in the midst of an FDA recall. Things don’t look good, so we are hesitant to recommend this supplement to dieters.

We suggest the use of a product that is both legal and safe. Losing a few pounds is not worth a significant health risk and you need to find a company with many reviews and scientifically proven ingredients.

Among the best products we’ve seen in 2015 is one called Leptigen. It uses a blend of four ingredients that have all been clinically proven to help burn fat and boost metabolism and the online reviews look great. We haven’t even found mention of side effects.

Oh, and the makers of Leptigen are offering a Special Trial Offer for the time being, which always shows confidence in the product.

Learn More About Leptigen »
GD Star Rating

How Does Methyldrene Elite Compare?

Previous Methyldrene Elite Review (Updated January 24, 2014):

What You Should Know

Click Here To See Our Highest Rated Review

Methydrene Elite is an ephedra supplement. The ingredients we found in the supplement are a classic ECA (ephedra, caffeine, aspirin) stack. This stack is no longer legal for use in diet supplements, according to the Food and Drug Administration. If this supplement contains real ephedra, and not some other extract of the same plant, the manufacturer, seller and buyer could be held legally responsible for the sale and purchase.

List of Ingredients


  • Vitamin B6
  • Vitamin B12
  • Chromium Picolinate
  • Caffeine Anhydrous
  • Ephedra Extract
  • White Willow Bark
  • 1, 3 Dimethylamylamine
  • Methylsynephrine
  • Phenylethylamine
  • Citrus Aurantium
  • Yohimbine HCL
  • Bauhinia Purpurea
  • Panax Ginseng
  • Bocapa Monniera
  • Cayenne
  • MCT Oil PWD
  • Black Pepper Extract

Product Features

Before taking out your credit card to purchase Methyldrene Elite, you may want to have your doctor do a full physical paying special attention to heart health. Methyldrene Elite contains caffeine, ephedra, citrus aurantium, methylsynephrine and yohimbine. These are all stimulants, with ephedra being one of the strongest stimulants on the planet. Ephedra is also addictive, as is caffeine. As if that long list of stimulants weren't enough, Methyldrene Elite contains 1, 3 Dimethylamylamine. This stimulant is associated with heart palpitations and other negative side effects. If you have a heart condition, liver disease, kidney disease or any other major health condition, you should not take this supplement because it could cause serious side effects.

Moving out of the stimulant category, we find phenylethylamine. This ingredient is included to boost the mood of the dieter. If the dieter feels happier, they are more likely to stick with the program and lose more weight. However, this small positive benefit is outweighed by the fact that some users have reported side effects similar to those associated with street drugs. Hallucinations and an extreme feeling of euphoria are two of the more common side effects.

See Our Featured


  • Ingredients for Methyldrene Elite are listed online.
  • The supplement will increase metabolism and weight loss.
  • The dieter will likely feel less hungry.


  • Methydrene Elite contains ephedra.
  • This supplement is illegal for sale in the United States.
  • The ingredient list shows a dangerous combination of stimulants.
  • The mood-altering ingredient may cause negative side effects similar to street drugs.


We rarely come across ingredient lists like the one listed for Methyldrene Elite anymore. When the FDA banned ephedra for use in diet supplements, the market calmed down a bit, but there are still a few companies hanging on to those old formulas known to cause horrible side effects for some dieters.

Before taking this supplement, contact the manufacturer and inquire about the source of ephedra and how this supplement is still being sold in the United States without FDA regulation.

One User Review About Methyldrene Elite

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  • 1
    manoj saini

    What is tha side effects methyl drene


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