Orlistat Review

Editor's Review: 3.9 / 5.0

What You Should Know

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Orlistat is a weight loss drug which is designed to deal with weight loss in overweight adults. It was approved by the Food and Drugs Administration in 1999 as a prescription drug. Orlistat is the generic name, and the prescription form of the drug is known under the brand name of Alli. In 2007, the Food and Drugs Administration approved a lower dosage over the counter form of Orlistat known as Xenical. Xenical is produced and sold by GlaxoSmithKline.

List of Ingredients

Alli (60mg), Xenical (120mg)

Product Features

Those who market and sell the various forms of Orlistat tell us that it can be taken up to three times a day with each main meal and that it is designed to be taken in conjunction with a healthy diet and exercise program. Of course, synthetic drugs such as Orlistat should be a last resort solution to weight loss. We are told that Orlistat works by binding to an enzyme known as gastrointestinal lipase which inhibits the action of this enzyme. This action is said to play a role in breaking down consumed fats. Those who market and sell the prescription form of Orlistat as well as the over the counter form claim that it breaks down thirty percent of fat which is ingested and prevents it from being absorbed. We are told that Orlistat is not suitable for anyone who has had an organ transplant, suffers from a thyroid problem or suffers from diabetes. Side effects of this drug include changes in bowel movements, as well as menstrual irregularities. Some experts claim that in certain individuals it can lead to behavioural changes. It also interferes with the absorption of certain vitamins in the body.

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  • Orlistat is available both in prescription form and as an over the counter drug.
  • Some of the contraindications for this drug are listed on line.
  • The over the counter form of Orlistat can be ordered directly online.


  • Orlistat is not suitable for anyone who has a thyroid problem or suffers from diabetes.
  • Side effects can include behavioural changes, changes in bowel movements and menstrual irregularities.
  • Orlistat is not the only enzyme inhibiting weight loss drug on the market.
  • We are provided with no evidence which shows that Orlistat is more effective than other enzyme inhibiting weight loss drugs.


At the end of the day, due to the fact that Orlistat interferes with the chemistry of the body by blocking Enzymes, we feel that it is a weight loss solution of last resort when other avenues have been exhausted. Even though a low dosage form of Orlistat is available as an over the counter drug, we are of the opinion that anyone who wishes to take Orlistat in any form should first seek the advice of their Physician.

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22 User Reviews About Orlistat

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  • 1

    Plz anyone in pak who using ths orlistate contain ORSLIM TABLETS tel me wht r the side effects of it. And if we use it. How many days or month it should take? How much weight we can loose.? Plz must let me know.


  • 2

    my age is 21 ,height 5ft and 9 inch i got pcos weight is 99 can i use these tablets to lose weight ??is it safe for me as i hav pcos


    Karen (Editor)

    Hi Rida. It’s important you ask your doctor if this or any product is is agreeable to your body’s chemistry.


  • 3
    afzal khan

    my pcnl operation is done on 20.05.2015 my height is 6 ft. my weight is 98 I start orlistat slim trim active tablets 120 mg.two time a day after meal i continue this or stop some time



    is there any side effect on stomach after longtime used atleast how many month we can use


  • 4

    Sir/madam my weight is 100 kg.i have no any medical problem can I start orslim tablets 120 mg.two time a day after meal please give me quick reply.if you want to suggest any thing so please do it


  • 5

    i want more details iam 108kg male


  • 6

    Can i take orslim without multivitamin?? Coz my dr prescribed me only orslim n she says orslim can ne taken alone


  • 7

    what is the recommended daily dosage for orlistat


  • 8

    is it good to take orlistat even when u took it after drinking coffee?


  • 9

    y is it not fit for diabetics?


  • 10

    orlistat been taken off the shelves do you knw when it will be going to be put back as was told there was a manufacturing problem.


  • 11

    is orlistat is safe for nursing women



    Since this is a drug for reducing fat intake it would not be good for nursing women to take it since you would need enough nutrients in your milk for the child, and fat is important in development. If you do not have enough nutrients in your milk for the child, the child could have deficiences.


  • 12

    Take this pill only when you will be having a fatty meal (it happens). A friend of mine took about one pill a day for a month, some days she didn’t take any, because they’re so expensive here. So if you restrict yourself to taking the pill when you eat something heavy and greasy, you can mask out any fat from your diet. You must take a multivitamin with it as you lose Vitamins A, D, E and K (which are found in fat). I personally find this pill draining, I get tired for some reason. Also some people feel the need to go to the bathroom right after, but for me it takes about 3 hours. Hope my comment is useful!


  • 13

    why is sigma orlistat more effective than xenical orlistat?


  • 14

    My friend takes Orlistat 60 a blue capsule, she said that it works great to lose weight, she does not appear to have lost any, is the Orlistat 60 over the counter or perscription, I have slightly high blood pressure is it safe if it is over the counter?


  • 15

    I used this product with supervision from my doctor in mexico and as long as i followed the diet he gave me and took the pill twice a day i lost about 60 lbs in 3 1/2 months i havent gained the wieght back like u usually do with other pills I really liked it….



    Is Orlistat 60 an over the counter or perscription?



    what type of foods were on your meal plan that contained fat? please give me an idea as the desc mentioned that it shouldnt be taken with meals that dont contain fat. thanks a bunch! hopefully you see this



    Even i am a thyroid patient. I do not have much of junk food and love eating vegetables, but post thyroid i gained some weight, also since i had to consume other medicines i gained more weight. It has become difficult to lose weight despite exercising. I have been prescribed orlistat 60mg from my doctor who never told me of any side effects since i am a thyroid patient. Could any one please help me know what could be the side effects for a thyroid patient?


  • 16

    why is orlistat contraindicated for thyroid pts?


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