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Orlistat Review - Does This Fat Blocker Work? Are side effects and minimal results deal breakers?

By Summer Banks on Sep 08, 2016
Orlistat Review

Diet products either work or they don’t. Period. Let’s find out which one Orlistat is. We wanted to know what science had to say, so we decided to dig deeper into ingredients, side effects, clinical research and customer service quality. Furthermore, we examined hundreds of user comments and feedback. Then, we summarized and condensed to give you the info you need.


What is Orlistat?

First off, Orlistat is an ingredient found in over-the-counter supplement Alli 60mg and prescription medication Xenical 120mg. It promotes weight-loss and treats obesity by blocking the absorption of fat. You’ll take one capsule, three times per day, one hour prior to meals. The company also recommends eating a healthy diet, drinking water and taking a multi-vitamin. One benefit is that you don’t need a prescription for the 60mg version.

The prescription version of Orlistat is offered by Roche, while GlaxoSmithKline makes the over-the-counter supplement. It’s been available since at least 2007. The official website doesn’t sell it, but provides a list of retailers that do. We like that it’s approved by the Food and Drug Administration (FDA) and that we found some favorable customer comments, but read on…

Side Effects – “Any Positives?”

The first concern was the Orlistat side effects. “We like that this one is used to treat obesity,” said our Research Editor. “But the occurrence of adverse reactions is quite concerning.”

“Very bad skin reaction. I’m still with the problem after 20 days. It’s the worst thing; it’s like your blood is burn inside and the itchiness won’t stop,” stated a customer.

“I started getting nausea and abdominal pains,” reported another.

We found that some dieters didn’t experience negative side effects like others did. “The expected side effects have really been minimal to almost non-existent,” said a user.

Minimal Results – “Not Losing Weight?”

Based on customer comments, minimal results from Orlistat ingredients were concerning. “I’ve been taking for about three weeks and so far, it really hasn’t made a significant difference. So I have decided to just increase the intensity of my workouts,” commented a dieter.

“Alli has changed…it’s no longer effective. I even tried prescription orlistat…also, no effect,” stated a consumer.

What we like seeing is when dieters share their more positive experiences. “My belly has already decreased. I don’t feel as bloated,” said a customer.

“I have been using this product for over a week and I have already lost weight. I have been both watching my calories and exercising at least 30 minutes a day but nothing too rigorous,” reported another.

The Science – “What Does Research Say?”

Considering Orlistat is approved by the FDA, we found the research showing that it promotes weight-loss. The catch is that no more than 30% of the calories eaten per meal should come from fat. Also, eating foods with high-fat content increase the chances of negative side effects. We at DietSpotlight like seeing clinical studies used to support a supplement. What’s concerning is that results could be overshadowed by adverse reactions.

The Bottom Line – Does Orlistat Work?

Are you heading out to buy Orlistat? Well, we like that we found some positive customer comments. It’s also FDA-approved. While it’s used to treat obesity, research shows it could lead to adverse reactions. Also, we’re hesitant about making suggestions about this one due to customer reports relating to negative side effects and the lack of results.

We want you to feel safe when you lose weight, so we suggest you go with a supplement containing ingredients shown to work that’s not connected to harmful side effects.

Among the best products we’ve seen in 2016 is one called Leptigen. The supplement contains four clinically-tested ingredients promoting weight-loss by helping accelerate metabolism and ignite fat loss. There’s no chatter about harmful side effects, but the results reported by dieters are amazing.

Also, the company behind Leptigen is offering customers a Special Trial Offer. This is an excellent sign of confidence in their supplement.

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About the Author:

Summer Banks is an ISSA-Certified Fitness Nutrition Specialist and has reviewed over 2000 diet products. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

How Does Orlistat Compare?

Previous Orlistat Review (Updated August 12, 2013):

What You Should Know

Orlistat is a weight loss drug which is designed to deal with weight loss in overweight adults. It was approved by the Food and Drugs Administration in 1999 as a prescription drug. Orlistat is the generic name, and the prescription form of the drug is known under the brand name of Alli. In 2007, the Food and Drugs Administration approved a lower dosage over the counter form of Orlistat known as Xenical. Xenical is produced and sold by GlaxoSmithKline.

List of Ingredients

Alli (60mg), Xenical (120mg)

Product Features

Those who market and sell the various forms of Orlistat tell us that it can be taken up to three times a day with each main meal and that it is designed to be taken in conjunction with a healthy diet and exercise program. Of course, synthetic drugs such as Orlistat should be a last resort solution to weight loss. We are told that Orlistat works by binding to an enzyme known as gastrointestinal lipase which inhibits the action of this enzyme. This action is said to play a role in breaking down consumed fats. Those who market and sell the prescription form of Orlistat as well as the over the counter form claim that it breaks down thirty percent of fat which is ingested and prevents it from being absorbed. We are told that Orlistat is not suitable for anyone who has had an organ transplant, suffers from a thyroid problem or suffers from diabetes. Side effects of this drug include changes in bowel movements, as well as menstrual irregularities. Some experts claim that in certain individuals it can lead to behavioural changes. It also interferes with the absorption of certain vitamins in the body.

See Our Featured


  • Orlistat is available both in prescription form and as an over the counter drug.
  • Some of the contraindications for this drug are listed on line.
  • The over the counter form of Orlistat can be ordered directly online.


  • Orlistat is not suitable for anyone who has a thyroid problem or suffers from diabetes.
  • Side effects can include behavioural changes, changes in bowel movements and menstrual irregularities.
  • Orlistat is not the only enzyme inhibiting weight loss drug on the market.
  • We are provided with no evidence which shows that Orlistat is more effective than other enzyme inhibiting weight loss drugs.


At the end of the day, due to the fact that Orlistat interferes with the chemistry of the body by blocking Enzymes, we feel that it is a weight loss solution of last resort when other avenues have been exhausted. Even though a low dosage form of Orlistat is available as an over the counter drug, we are of the opinion that anyone who wishes to take Orlistat in any form should first seek the advice of their Physician.

45 User Reviews About Orlistat

Leave comments below
  • 1

    I want to know can it b use for unmarried girl and having no side effect aftr marriage in pregnecy



    Hello Ayesha! All users are different and can experience different weight-loss results, please make sure to consult with your physician before taking this product.


  • 2

    hy..my wife use orslim orlistst before marriage..she lose 20 kg wait…now after marriage…we have a baby…n she gained very much wait again..she wants to use these capsules again…


    Anna (Editor)

    Hello. All users are different and can experience different results, but please have her consult with her physician before taking this product.


  • 3
    Muhammad Yousaf

    Hi this Yousaf and I am 36 years old. My weight is 122kg and my Family doctor advised me for taking Orslim 120 two tablets in each day.
    Now my question is shoud I use these medicine with exercises and Running and should I do my diet control or without these thing shoul I use this medicine.
    I mean to say it effect without any exercise and diet or I will do exercise and diet with this medicine.
    Also tell me what time is required for my reduction of body ?

    Please reply me in your good points.




    Adrian (Editor)

    Hi Yousaf! For detailed product and usage instructions, please refer to Orlistat’s official website for more information.


  • 4

    I am a thyoride patient and my doctor prescription me this medicine after using this medicine I have pain in stomach what should I have to now sides of stomach


    Candace (Editor)

    Please ask you doctor regarding your other medicines.


  • 5

    We should use that before food or after food


    Stephen (Editor)

    It can be taken up to three times a day with/before each main meal.


  • 6

    Sir i am unmarride and my age is 25 years old. can i use it? my doc reffered it. please tell me how i can use it


    Stephen (Editor)

    It can be taken up to three times a day with each main meal, Ayesha.


  • 7

    I just start using this Medicine , and i feel its effective , but i want to be a sure about disadvantages and effects . and also i want to know the difference of FAKE and REAL ORSILIM , because i am afraid to get fake one , waiting your feedback


    Stephen (Editor)

    Hey, Junaid. If you are confident in the effects then you likely have the real one. What is the name of the company on the bottle?


  • 8

    hi I am using now ORSLIM .my age is 18 and my weight is 65 .I have problem of irregularities of periods .my doctor concult these tablets .doctor said I should lose my weight then I can solve this ghynocological problem .shoul I use this please tell me.


    Arnold (Editor)

    Hi Rabia, even though Orlistat looks promising we did come across potential side effects that cause it to be unsuitable for those thyroid problems, diabetes or issues with menstruation. Please consult your doctor once more.


  • 9

    Hello..I want to use orslim tblts..I’m 30 years old n weight is 94 kgs…I’m unmarried..I do nt hav any health issu..can I use it without cnsltng dr???


    Arnold (Editor)

    Sani you should always consult a doctor. This product is the generic form of a prescription drug called Alli.


  • 10
    Your Name

    Can it be taken during menstrocycle.


    Devon (Editor)

    Hi, we couldn;t find a reason why it shouldn’t. Be safe and ask your doctor.


  • 11

    Sir l have used this medicine 6 months ago . Can I use this medicne again .l am 17 years old with weight 71 kg .My height 5’7


    Devon (Editor)

    Well, Muskan, ordinarily these supplements are for people who are 18 years of age or older. Just make sure your doctor signs off on it for you.


  • 12

    Plz anyone in pak who using ths orlistate contain ORSLIM TABLETS tel me wht r the side effects of it. And if we use it. How many days or month it should take? How much weight we can loose.? Plz must let me know.


  • 13

    my age is 21 ,height 5ft and 9 inch i got pcos weight is 99 can i use these tablets to lose weight ??is it safe for me as i hav pcos


    Karen (Editor)

    Hi Rida. It’s important you ask your doctor if this or any product is is agreeable to your body’s chemistry.


  • 14
    afzal khan

    my pcnl operation is done on 20.05.2015 my height is 6 ft. my weight is 98 I start orlistat slim trim active tablets 120 mg.two time a day after meal i continue this or stop some time



    is there any side effect on stomach after longtime used atleast how many month we can use


  • 15

    Sir/madam my weight is 100 kg.i have no any medical problem can I start orslim tablets 120 mg.two time a day after meal please give me quick reply.if you want to suggest any thing so please do it


  • 16

    i want more details iam 108kg male


  • 17

    Can i take orslim without multivitamin?? Coz my dr prescribed me only orslim n she says orslim can ne taken alone


  • 18

    what is the recommended daily dosage for orlistat


  • 19

    is it good to take orlistat even when u took it after drinking coffee?


  • 20

    y is it not fit for diabetics?


  • 21

    orlistat been taken off the shelves do you knw when it will be going to be put back as was told there was a manufacturing problem.


  • 22

    is orlistat is safe for nursing women



    Since this is a drug for reducing fat intake it would not be good for nursing women to take it since you would need enough nutrients in your milk for the child, and fat is important in development. If you do not have enough nutrients in your milk for the child, the child could have deficiences.


  • 23

    Take this pill only when you will be having a fatty meal (it happens). A friend of mine took about one pill a day for a month, some days she didn’t take any, because they’re so expensive here. So if you restrict yourself to taking the pill when you eat something heavy and greasy, you can mask out any fat from your diet. You must take a multivitamin with it as you lose Vitamins A, D, E and K (which are found in fat). I personally find this pill draining, I get tired for some reason. Also some people feel the need to go to the bathroom right after, but for me it takes about 3 hours. Hope my comment is useful!


  • 24

    why is sigma orlistat more effective than xenical orlistat?


  • 25

    My friend takes Orlistat 60 a blue capsule, she said that it works great to lose weight, she does not appear to have lost any, is the Orlistat 60 over the counter or perscription, I have slightly high blood pressure is it safe if it is over the counter?


  • 26

    I used this product with supervision from my doctor in mexico and as long as i followed the diet he gave me and took the pill twice a day i lost about 60 lbs in 3 1/2 months i havent gained the wieght back like u usually do with other pills I really liked it….



    Is Orlistat 60 an over the counter or perscription?



    what type of foods were on your meal plan that contained fat? please give me an idea as the desc mentioned that it shouldnt be taken with meals that dont contain fat. thanks a bunch! hopefully you see this



    Even i am a thyroid patient. I do not have much of junk food and love eating vegetables, but post thyroid i gained some weight, also since i had to consume other medicines i gained more weight. It has become difficult to lose weight despite exercising. I have been prescribed orlistat 60mg from my doctor who never told me of any side effects since i am a thyroid patient. Could any one please help me know what could be the side effects for a thyroid patient?



    Dear molly can u tell me what diet u were following along with orslim


  • 27

    why is orlistat contraindicated for thyroid pts?


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