Updated: 07/19/2016 - Site operated by Leptigen

Phenadrine Review - Does This Fat Loss Supplement Really Work? Are questionable ingredients and adverse effects deal breakers?

By Summer Banks | Published: 06/12/2016
Phenadrine Review

Don’t laugh, but well over 50% of diet products simply don’t work. So what about Phenadrine? We did one of our in-depth reviews, examining the ingredients, side effects, clinical research and customer-service quality. Furthermore, we looked at hundreds of customer comments and user posts from around the internet. Lastly, we then summarized and compressed the data we found to give you the info you need.

EDITOR'S TIP: Click here to substitute Phenadrine with a proven fat burner such as Leptigen for better results.

What is Phenadrine?

To start, Phenadrine is boasted as the “world’s strongest diet and energy aid.” This supplement is made by APS Nutrition and it’s supposed to help you get more intense workouts, improve focus, enhance alertness and get rid of unwanted pounds. To use it, you need to take one capsule each morning (or before a workout) and afternoon. The ingredients in this supplement include Acacia Rigidula Leaf Extract, Theobromine, 1,3 Dimethylamylamine, Extend-Rx Naringin Fruit, Caffeine Anhydrous, N-Acetyl-L-Tyrosine and Methylsynephrine.

This product has been available since at least 2010 and it’s easy to purchase via the official website. Some natural plant extracts are found in Phenadrine and this product is easy to use anywhere, but read on…

Questionable Ingredients – “Concerning?”

First off, we are a bit concerned with Phenadrine ingredients. According to our Research Editor, “This product contains Synephrine, which comes from Citrus Aurantium or Bitter Orange. It mimics the effects of Ephedra (a banned weight-loss ingredient) by increasing blood pressure and heart rate. Unfortunately it has been associated with serious health problems.”

One user commented, “This pill made my heart race like crazy. Pretty scary!”

Another person stated, “Not sure Phenadrine is actually safe. It makes be feel like I’m on drugs.”

Adverse Effects – “Another Potential Problem?”

It’s clear that Phenadrine side effects are an issue for some users. One customer said, “Leaves a horrible burn in my stomach, is this normal??? I am kind of scared to take it any longer.”

“Gives me a very uncomfortable pain in my stomach. It almost feels like an extreme case of heart burn, it just hits a bit lower!,” commented another user.

Our research has shown if there is some particular part of a diet product that is especially troublesome (a painful/difficult exercise routine, dangerous ingredients, adverse reactions) the chances of long-term weight-loss results are slim. So, if Phenadrine does in fact cause side effects in a lot of people, this could be problematic.

Any Solid Science?

Science is mentioned on the official website for Phenadrine. However, there are no actual clinical studies presented to support this product and its weight-loss claims. Here at DietSpotlight, we prefer to see published research that supports the supplement we are reviewing.

The Bottom Line – Does Phenadrine Work?

Now the moment you’ve been waiting for: our bottom line on Phenadrine. Well, we like that it is easy to use anywhere and it contains some natural plant extracts. However, we have some reservations about it because it’s not backed by actual clinical studies. Also, we’re concerned about its questionable ingredients and the adverse effects it causes some users.

If you’d like to drop more weight, then we advise you to go with a product that is backed by real clinical tests, does not cause harmful effects and does not contain any dangerous ingredients.

Among the best products we’ve seen in 2016 is one called Leptigen. Its formula is a unique blend of four ingredients, which have been shown in documented clinical research to help improve fat loss and boost metabolism. We can’t pinpoint much talk of side effects and user comments around the web indicate people are seeing great results.

The makers of Leptigen are so sure about their product they’re offering a Special Trial Offer, which is a positive sign.

Get Your Sample Today »
About the Author: Summer Banks

Summer has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

How Does Phenadrine Compare?

Previous Phenadrine Review (Updated January 1, 1970):

What You Should Know

Click Here To See Our Highest Rated Review

The weight loss supplement Phenadrine is manufactured and sold by the South African Company Biogen. The main active ingredients in this product include Citrus Aurantium, Green Tea Extract and Yerba Mate. These ingredients are extremely popular ingredients in weight loss products on the market today. Although there is an official website for the products produced by Biogen, it does not give any information on the purchase price of Phenadrine.


The ingredients in Phenadrine include White Willow Bark, Citrus Aurantium, Green Tea Extract, L-Tyrosine, L-Tyrosine and Octopamine.

Product Features

Phenadrine cannot be ordered directly from the official website for Biogen products but can only be purchased in person in pharmacies in South Africa. This will make it rather difficult for some who does not live in South Africa to purchase this product. Those who take aspirin regularly or similar medication regularly should not use Phenadrine due to the inclusion of White Willow Bark in this product. There are also a number of stimulants in Phenadrine which means that you may want to cut down on the amount of coffee that you drink if you do decide to take Phenadrine. Green Tea Extract which is present in this product is one of the most popular ingredients in weight loss products on the market today. He We are given no information as to what makes Phenadrine more effective than other weight loss supplements on the market which contain Green Tea Extract. Some experts warn that Citrus Aurantium which is present in Phenadrine may increase the risk of a stroke. It was at one time thought to be a safe alternative to the now banned Ephedrine, but not any more. There does not seem to be an offer of a money back guarantee upon purchase of Phenadrine.

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  • There is an official website for Biogen, the Company which manufactures Phenadrine.
  • There is a full and comprehensive list of ingredients in Phenadrine.
  • There are contact details given on the official website, should you wish to contact a representative of Biogen.


  • Phenadrine can only be purchased in pharmacies in South Africa.
  • Some experts believe that Citrus Aurantium which is present in Phenadrine can increase the risk of a stroke.
  • Those who take aspirin regularly or similar medication should not use Phenadrine due to the inclusion of White Willow Bark in the product.
  • There is no evidence that Phenadrine is more effective than other products on the market which contain similar ingredients.


The fact that this product is only for sale in pharmacies in South Africa restricts the number of consumers who will be able to purchase this product. In any event there is no evidence that it is more effective than other products for sale which contain similar ingredients.

Phenadrine Questions & Answers:

We dissected hundreds of customer comments about Phenadrine for this FAQ.

What are the side effects of Phenadrine?

According to some customer reviews, Phenadrine side effects may include stomach pains, heart burn, high heart rate, and high blood pressure.

What are the ingredients in Phenadrine?

Phenadrine ingredients include senegalia beriandieri extract, b-phenylethylamine, methylsynephrine, n-methyl b-phenylethlyamine, n-methyl b-methylphenylethylamine, n-dimethyl, beta-phenylethlyamine, n-acetyl-l-tyrosine, caffeine anhydrous, naringen/bergamottin fruit, 3 dimethylamylamine HCl, and theobromine.

Does Phenadrine work?

There is some clinical support for caffeine, which comes in two sources with Phenadrine. However, you have to look at the methylsynephrine. When this ingredient is combined with caffeine the risk of stimulant-related side effects increases dramatically.

If you are looking for a supplement with clinically tested ingredients, you may want to take a look at Leptigen.

How much does Phenadrine cost?

For a bottle of 60 capsules, Phenadrine costs about $59.95.

How should I take Phenadrine?

It is suggested that you use Phenadrine twice a day. One capsule should be taken in the morning and another should be taken in the afternoon. The makers highly suggest against using more than three capsules a day.

Can I take Phenadrine if I have a health condition?

Just as with any weight-loss supplement, you should consult your physician before taking Phenadrine, especially if you are pregnant, nursing, under 18, or suffering from any health condition.

What do users like about Phenadrine?

Customers like the rush of energy they receive while using Phenadrine.

What do users NOT like about Phenadrine?

Users do not like the reports of adverse side effects and the building cost of Phenadrine.

How do I contact the Phenadrine customer service department?

You can contact the makers of Phenadrine by calling them at 1-800-855-7919. They also have multiple social media platforms.

Will Phenadrine show up as a positive result for a drug test?

Since Phenadrine contains a similar chemical formula to amphetamine, you may show up positive in urine test.

How long can I take Phenadrine?

Phenadrine can be potentially habit-forming. Makers suggest you only take the supplement for three months because of this factor.

Does Phenadrine come with a guarantee?

Phenadrine does not come with a guarantee.

Do you know of any special deals or discounts on Phenadrine?

If you are in the military or are a veteran, you can obtain a code that gets you 25% off. However, you should check out Leptigen, which is offering a Special Trial Offer customers cannot get enough of. Users keep reporting positive results, something not many companies can attest to. Click here to try it out.

15 User Reviews About Phenadrine

Leave comments below
  • 1

    I bought the phenadrine extreme coz I want to lose weight but now I am having doubts as I’m on arv’s, do you think it will affect my health?


    Cameron (Editor)

    Only your doctor could advise you on taking this supplement along with your ARV medication.


  • 2

    After my first dose today of 1 cap at 6:20 I felt a surge of clean energy till about 8 am then after my workout I came home and fell asleep for two hours feeling very lethargic.
    Nothing good to say so far.


  • 3

    I previously used CLA plus Phenadrine Lipo Zero Cut from Biogen and it worked like a bomb! Now after nearly 2 years and I have lost about another 13 kg because I had a big emergency operation – partitional removel of my stomach due to a ulcer and closure of pyloris. My weight stayed for 18 months 46 – 48 kg. I was extremely thin. I can now see & notice my clothes (3rd wardrobe!) I am gaining weight BUT do not want to exceed 50 kg and cannot afford a 4th wardrobe! I started taking cla ^ phenadrine lipo Zero Cut again after first asking my specialist as I cannot drink anything! He said yes but the cla is fine I think the phenadrine is giving me the following and I’m only taking half if the prescribed dosage daily. I get especially when I wake up a swollen but more windy stomach AND the most nasty is the BURP the whole day with a Very UNPLEASANT SMELL!!! Can it be a side effect & must I stop taking it? I didn’t take it for 2 days now (only the CLA) & the burp, smell & windy stomach is gone Or do you think I ate something. I really NEED to know if I can or not take the Phenadrine? And lastly if I keep on with the CLA is it helpful or useless? Please reply to my email asap. Thankyou.


  • 4

    it’s my second week using phenadrine slim stick, but i fell nausea always, i take them in the morning before my morning session and later just before 15h00


  • 5

    Ladies, I used thus before for about 2mnths. It works well particularly when combine with CLA 3000, e trick is to take it after breakfast, never on an empty stomach. This way you won’t suffer the cramps. It gives loads of ernegy too, you work like a zombie @ work and you sure get that bonus you deserve


  • 6

    Hi. I bought a box of phenadrine slim sticks, just to find that one of the sachets is empty. How do you suppose I handle this?


  • 7

    Leaves a horrible burn in my stomach too, is this normal??? I am kind of scared to take it any longer


  • 8

    I am having almost the same problems as Alan with this product. Gives me a very uncomfortable pain in my stomach. It almost feels like an extreme case of hart burn, it just hits a bit lower!


  • 9

    i started with the slim stick drink and within minutes got severe pains in my stomach that lasted 3o mins or so and left a nauseaus feeling the rest of the day. i waited a few days and took 2 tablets , they had exactly the same effect. too scared to take anymore .


  • 10

    why do we have to take it for 5 days and then stop for 2 days. I just started taking it for 5 days stopped on the 6th day and felt awful, sleepy and just want to eat.



    Hi Veloshnee. YOu should insure that you eat healthy during the period when consuming the 5 day period. There should be no reason for you to crave if you have been disciplinned during the 5 days. Alternate rather – take the tablets during the week, and rever to the Phenadrine slim stick drinks for the weekend! Great tasting and gives you that boost. Do not over indulge during your 5 day as it will affect your energy drive and is quite noticible should you stop for the 2 days if over consumed during the week..


  • 11

    Hi, Brent from South Africa here. I have been using the Biogen product for a short while and it really does what is claims to do. As an appetite suppressant it works great and in conjunction with light to mild exercise you will see results. Im not too sure about THC as a result of it though.


    Your Name

    I use Biogen Phenadrine and the “unnecessary” food cravings are a thing of the past.


  • 12

    Does Phenadrine test positive for THC in your system?


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