St Johns Wort Review

Editor's Review: 3.5 / 5.0

What You Should Know

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St. John’s Wort is an herb used for natural treatment of mood disorders, specifically depression. Studies have been conducted to test the efficacy of St. John’s Wort compared to prescription anti-depressants. Some studies, mostly from German speaking countries, have shown a positive result with fewer side effects. Others studies failed to repeat these findings. It is important to note that one study completed by the National Center for Complementary and Alternative Medicine found St. John’s Wort to be ineffective against the results of the placebo, but the study also found the same results for prescription anti-depressant Zoloft.

List of Ingredients

Herb – St. John’s Wort.

Product Features

The connection between St. John’s Wort and weight loss is simple. Weight loss, or failure to lose weight, can be linked to depression. Certain aspects of the weight loss journey like plateaus and weight gain while dieting can also lead to mood swings, including depression. If the dieter were to have more control over depression, they may feel better about dieting and stick with a plan longer and more closely.

Prescription anti-depressants like Meridia and Wellbutrin have been used as a medical means of weight loss for years. Some dieters have reported great effects and others no effects. The same can be said for St. John’s Wort. There could be dieters who feel a boost in mood and thus feel more dedicated to a weight loss plan.

The down side of St. John’s Wort is drug interaction. There is a long list of drugs such as antiretrovirals, benzodiazepines, hormonal contraception, immunosuppressants, antidepressants, opioids, CNS stimulants, 5-HT agonists and psychedelic drugs that could interact with St. John’s Wort. There is also evidence that sedation or anesthesia can cause a severe reaction when used with St. John’s Wort.

St. John’s Wort can be purchased in pill, capsule and tea form. The price starts at around $10 and can reach more than $30.

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  • Clinical trials prove it benefits people with depression.
  • The cost is far lower than other weight loss supplements.
  • Anti-depressants are commonly used with dieters wishing to lose weight.


  • Long list of possible contraindications with other medications and drugs.
  • St. John’s Wort is not used for weight loss.
  • The herb may not be effective for every person.


We are strong advocates of feeling good and losing weight. Supplements should include proven ingredients and St. John’s Wort could be considered proven. However, it is not safe for every dieter and the long list of possible interactions and drug contraindications could be too long for dieters to sort through with every medication they take.

In the case of immediate or emergency surgery, St. John’s Wort may interfere with anesthesia so attending physicians need to be made aware of supplementation within the last few weeks.

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5 User Reviews about St Johns Wort

  • 1

    the bottle says to take three a day…if I only take one will it do anything for me?


  • 2

    does saint johns wort cause itching as an allergy to the herb?


  • 3

    is st john wort good for depression


  • 4
    Sandra Carlson

    I take Crestor and Lisinopril
    will St. Johns Wart interfere with the meds?


  • 5
    robert arrowood

    I am diabetic, and am asking if St. Johns Wort will interact withMetformin,also Atenenol,