Updated: 09/29/2015 - Sponsored by Leptigen

Thyrene Review - Does This Diet Supplement System Work? Are cost and lack of results deal breakers?

Editor's Review: 3.5 / 5.0

thyrene-product-imageWe’ve heard a lot lately about diet supplement stacks that include Thyrene, so we did an in-depth review of the ingredients, side effects, clinical studies, and the quality of the company behind the product. We also looked at as many online reviews as we could to provide the information necessary to make an informed decision on this product.

EDITOR'S TIP: Substitute Thyrene with a proven fat burner such as Leptigen for better results.

What You Need to Know

Thyrene boasts a cocktail of ingredients designed to suppress appetite and help dieters lose weight through reduced caloric intake. Some of the ingredients include Vitamin B12 and B6, Calcium, Sodium, Kelp, Tyrosine, Phosphorus, Potassium, and more. The ingredients are well-structured and are designed to minimize side effects while helping you lose weight. These pills are also convenient and easy to take anywhere.

Thyrene has been a popular diet supplement since 2010. It stimulates the thyroid to supposedly help boost fat loss, and because there are no energy stimulants that boost metabolism, this pill can be taken multiple times per day. Thyrene is readily available online, and can be purchased in most health stores, but read on…

Price – “Yee-Ouch”

While Thyrene does have a relatively low price compared to many other supplements, some of the recommended product stacks can get extremely expensive. Most companies selling this product recommend you take this with at least 1 additional product, a metabolism booster, while some recommend a stack of up to 4 additional products. “These aren’t expensive by themselves,” said our research editor. “But when you add in the cost of the recommended stacks, the total cost can be $150-300 per month.”

“By itself Thyrene does nothing for me, but with the stack I can’t afford to keep taking it. It’s kind of a catch-22,” said one user.

“I thought I could afford this, but when I looked at the additional recommended products, I realized there was no way I could buy these every month,” said another.

Scroll below for one of the best products we’ve seen in 2015.

Lack of Results – Another Concern

For customers that didn’t opt to buy the entire stack of products, results were minimal or non-existent. Some customers saw minimal weight loss when they followed diet and exercise plans, while others saw no change without a significant change in their lifestyle. “I used Thyrene for 2 months and only lost 3 pounds,” said one customer.

“Thyrene is expensive and did nothing for me. I still felt hungry all the time,” said another. Most of the reviews agreed with these, but some offered helpful advice on how to make Thyrene work for you. “Thyrene isn’t to be used by itself. I took it with a metabolism booster, worked out every day, and ate healthier. After 2 months, I’ve lost 12 pounds,” said one satisfied customer.

According to our researchers and multiple studies, whenever there is an aspect of a diet supplement, weight loss program, or exercise routine that is troublesome (painful workouts, cost, side effects, lack of quick results, etc.) the dieter is less likely to achieve long-term success. If Thyrene really doesn’t help like many of the reviews say, it could make it difficult to achieve long-term weight loss goals.

The Science

Thyrene has plenty of strong claims about how it will perform for those trying to lose weight, but unfortunately those claims are not backed up by science. There have been no clinical studies supporting this supplement, and some of the ingredients have no scientific research behind their inclusion in Thyrene. At DietSpotlight we value unbiased information on a product, so when that research is missing and no clinical studies have been conducted it leads us to question the claims that a product is making. A supplement that has proven results and has been used in clinical studies is ideal, but unfortunately Thyrene does not offer that proof for those looking for an effective weight loss supplement.

The Bottom Line

At first we were excited to review Thyrene because it was easy to purchase, had some good reviews, and was free from side effects, but in the end we were disappointed. Thyrene has no scientific studies proving their claims or that their ingredients are supported by clinical studies, the recommended stacks to take with Thyrene can get very pricey, and the lack of results mean that weight loss is a long slow process with this supplement.

If you’re looking to slim down without the hassle and expense of a product like this, we suggest a supplement that offers scientific proof that its results will help you lose weight, an affordable price point, and quick and steady results.

One of our favorite products with proven results in 2015 is called Leptigen. Leptigen contains just four ingredients, which the makers have combined in a proprietary blend proven to speed weight loss by boosting your metabolism and burning fat. We’ve read the reviews online and customers seem to agree that this is an effective way to lose weight without negative side effects.

For a limited time, the makers of Leptigen are offering a special trial offer; putting their product on the line because they’re sure you’ll love it!

Learn More About Leptigen »

(Feel free to scroll below for our previously published full-length Thyrene Review)

Previous Thyrene Review (Updated January 20, 2014):

What You Should Know

Click Here To See Our Highest Rated Review

Thyrene is a product from Metabolic Nutrition that claims to boost fat loss by stimulating the thyroid. There are no stimulants in this formula, which could mean no fat loss or increased metabolism. We are not fond of thyroid stimulating supplements that make huge claims without any support for those claims. We know that 3, 5 Diido-L-Thyronine has some clinical support, but Metabolic Nutrition fails to use that support to validate this supplement.

Dieters looking to boost weight loss with a safe and effective supplement may wish to choose a different product. We could find no clinical studies supporting this supplement and one of the ingredients is available only from Metabolic Nutrition with no information about what it is or what it does listed on the website.

List of Ingredients


  • Folate
  • Vitamin B12
  • Calcium
  • Iodine
  • Potassium
  • Vitamin B6
  • Phosphorus
  • L-Tyrosine
  • Coleus Forskohlii
  • Guggulsterones
  • Di Potassium Phosphate
  • Calcium Phosphate
  • Sodium Phosphate
  • 3, 5 Diido-L-Thyronine
  • Kelp
  • Meridextrine

Product Features

Losing weight is about burning more calories than you consume. The thyroid plays an important role in the rate of your metabolism, but not many natural supplements have an effect on thyroid function, despite the outrageous claims of some companies. Thyrene makes those same outrageous claims, but at least one ingredient has been tested with positive weight loss results - 3, 5 Diido-L-Thyronine. Metabolic Nutrition does not list the available clinical support for this ingredient, however. That could be because the weight loss associated with the ingredient is not that remarkable.

The other ingredients in the Thyrene formula are commonly found in other weight loss supplements. None of them have a significant impact on metabolism as none have stimulant properties.

The instructions for taking the supplement are more confusing than some other products. The dieter is supposed to start off by taking one capsule three times a day. Then, after gauging how the body reacts, up the dose to two capsules three times a day. There is no description of the possible feelings the dieter could have or how to gauge if the supplement is too strong and since there are no stimulant ingredients we're unsure how the dieter is supposed to know when to up the dose.

See Our Featured Diet


  • We easily found the ingredients online.
  • No stimulants so the supplement can be taken multiple times a day.


  • The dieter is left to choose when to take the maximum dose.
  • No stimulants means no increase in metabolism.
  • No appetite suppressants included in the formula.


Thyrene could be considered a safe supplement, but there is one problem. Meridextrine is an unknown ingredient found in most Metabolic Nutrition supplements. We've said throughout that this supplement contains no stimulants, but that may not be completely true. There is a chance that Meridextrine is a stimulant and if that is the case, some dieters may feel negative side effects.

GD Star Rating

2 User Reviews About Thyrene

Leave comments below
  • 1

    I have been an avid fan of Cellucor (although I know its expensive) I have been using CLK & Super HD (8 weeks on 3 weeks off) for about 2 years!… However, after I was given a sample of Synadrex (*The New Formula is amazing!!) about a week ago I have decided to start a new stack using Synadrex, Thyrene, Phenolox, & a simple Multi-vitamin (and cellucor CLK).
    My plan is to alternate Synadrex and Phenolox (Synadrex on Monday and Phenolox on Tuesday *1pill a day) then add Thyrene after a week (*1pill a day) and continue taking CLK (up to 6 pills a day but I usually only take 3)
    One thing people need to understand is that there are no miracle pills on the market… if there were, the government would paten it, classify it as a controlled substance and only give it to the soldiers in the army 😛 lol

    On a more serious note: (*I can not rate this product yet) As far as Thyrene goes…. metabolicnutrition.com states:
    Due to the strength of THYRENE, please assess your tolerance by initially taking only 1 capsule upon awakening for the first 3 days. After assessment, if effects last longer than 15 hours, consider altering dosage to every other day. With caution, you may increase up to 1 capsule in the AM and 1 capsule at Noon. DO NOT exceed more than 2 capsules daily or 12 hours prior to desired bedtime.
    Only Synedrex, Phenolox and Hydravax may be combined with THYRENE for a more customized weight loss solution. DO NOT combine with other non approved supplements or medications.


  • 2
    simone manoo

    on d first day i took one pill i started feeling pins sticking me through my skin y is tht an a pain in my stomach should i stop it


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