Zygest Review

Editor's Review: 3.5 / 5.0

What You Should Know

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Zygest is a digestive enzymes supplement formulated by Physiologics. The supplement contains the three main digestive enzymes protease, amylase and lipase. Protease is responsible for breaking down protein; amylase for carbohydrates and lipase for fats. The Physiologics websites offers several clinical studies supporting the use of digestive enzymes for improved digestion. Some studies were performed on humans and others using computer models. The official website for Zygest lists a reference sheet and product label, but the supplement is not listed for sale. The References section lists several journal resources, but none we are familiar with.

Digestive enzymes may help breakdown food for proper absorption, but they will not benefit weight loss.

List of Ingredients

Zygest Blend 104 mg contains: Bromelain (form Pineapple) 120 GDU1, Papain (from Papaya fruit) 600,000 FCCPU2, Protease 3.0 (from Aspergillus oryzae) 10 SAPU3, Amylase (from Aspergillus oryzae) 400 DU4, Lipase (from Aspergillus niger) 60 FCCLU5, Protease 4.5 (from Aspergillus oryzae) 400 HUT6, Lactase (from Aspergillus oryzae) 20 ALU7, Cellulase (from Trichoderma longbrachiatum) 10 CU8, Hemicellulase (from Aspergillus niger) 10 HCU9.

Product Features

The majority of the product description for Zygest explains the functions of protease, amylase and lipase. Some of the descriptions use clinical terms that may be difficult for some dieters to understand. Basically, the digestive enzymes promote the breakdown of food in the intestine. The faster food is broken down, the more nutrients and vitamins the body can absorb. Digestive enzymes naturally occur in the body and not all dieter need additional enzyme support. In some cases, doctors may suggest using Zygest or a similar product if gas and bloating occurs after eating certain foods.

Zygest may actually hurt dieters more than help them. If taken after eating a large meal, Zygest may relieve discomfort associated with overeating. Dieters may feel they can overeat as much as they like because they no longer feel overfull when they do.

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  • Helps break down foods for proper digestion.
  • A product reference sheet is listed on the Physiologics website.
  • All ingredients are listed in label format.
  • Proven to improve digestion.


  • Not necessary for weight loss.
  • Not all dieters need enzyme support.
  • Zygest is not listed for sale on the Physiologics website.
  • Will not improve weight loss or metabolism.
  • The reference section does not include any familiar journals.


Digestive enzymes provide much needed support for dieters with digestive issues, like gastric bypass patients, but the body makes all the digestive enzymes it needs to promote healthy digestion and nutrient absorption. There are several clinical studies referenced on the Physiologics website proving digestive enzymes breakdown food, but this is not in question. The benefit to dieters taking the supplement is not discussed in the product description.

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