People still talk about the wakefulness agent Adrafinil. It seems to work, so we wanted to know how. We didn’t buy into the hype, so we focused our research on the ingredients, side effects and clinical studies. For decades, customers have used it, so we read through their experiences. Then, we gathered all the details to give you the facts without the fluff.
What is Adrafinil?
Adrafinil (also known as Olmifron or CRL-40028)  is a eugeroic (wakefulness-promoting) or nootropic (memory or other cognitive function-enhancing) drug. It is a precursor to Modafinil, which is the more commonly available version of this drug.
Modafinil and Adrafinil are wake-promoting agents used in the treatment of narcolepsy. 
Modafinil is classified as a Schedule IV prescription drug in the United States, making it illegal to possess without a prescription.
Adrafinil is a pro-drug: it is primarily metabolized in vivo to modafinil, resulting in nearly identical pharmacological effects.
Unlike Modafinil, however, it takes time for the metabolite to accumulate to active levels in the bloodstream. 
Effects usually are apparent within 45–60 minutes when you take it orally, on an empty stomach.
The Company Behind Adrafinil
French pharmaceutical company Lafon Laboratories developed the drug in the 1970s, and they originally introduced it to the European market in 1986 under the brand name Olmifon.
U.S.-based pharmaceutical company Cephalon purchased Group Lafon in 2001. 
Adrafinil is a mild, central nervous system stimulant drug that relieves excessive sleepiness and inattention in elderly patients.
Individuals, such as night workers or others who need to stay awake and alert for long periods of time, also use it off-label to avoid fatigue. 
Other studies also believe that it “activates the noradrenergic and dopaminergic systems.” 
It does not currently have FDA approval and is thus unregulated in the United States.
It was marketed in France and elsewhere in Europe under the trade name Olmifon until September 2011, when France’s FDA equivalent reassessed the drug and withdrew marketing permission.
The active ingredient in the drug is Modafinil. Adrafinil increases the Modafinil levels in the body. Other ingredients include gelatin, silicon dioxide, cellulose, and magnesium stearate.
Differences Between Adrafinil and Modafinil
- As we mention above, Adrafinil metabolises into Modafinil when inside the body. Technically, adrafinil and Modafinil are identical in terms of what they pharmacologically do.
- Adrafinil is much less potent than modafinil. You would need about twice the quantity of adrafinil to get the same effect as modafinil.
- The US does not regulate Adrafinil and you may find it as a dietary supplement; modafinil is a schedule IV drug that needs a prescription.
- You can find Adrafinil online and buy it as a nootropic and nutraceutical, but you can only illegally buy modafinil.
- A normal adrafinil dose is 300-600mg; modafinil’s is 200mg.
- Adrafinil’s half-life is around five hours, with longer-lasting effects as modafinil has a 14-hour half-life.
- Adrafinil is a white/orange powder, while modafinil is white or off-white.
Adrafinil Side Effects
Common side effects of Adrafinil include: 
- Trouble sleeping
- Lack of appetite
Less common side effects
- Low blood pressure
- Rapid heartbeat
- High blood pressure
- Mood changes
Rare side effects
- Abnormal liver function
- Decreased white blood cells
If you suddenly stop using this medication, you may have withdrawal symptoms (shaking, sweating, chills, nausea, vomiting, confusion). To help prevent withdrawal, your doctor may lower your dose slowly. Withdrawal is more likely if you have used modafinil for a long time or in high doses. 
Adrafinil and Modafinil are used to relieve excessive sleepiness and inattention in elderly patients and those suffering from narcolepsy.
Some people use it off-label to avoid fatigue (for example when doing shift work or working long hours).
Does Adrafinil Work?
It is effective at promoting wakefulness, and a study showed that it promoted wakefulness over a 30-hour testing period in sleep-deprived adults. 
Modafinil was found to impair post-sleep-deprivation restorative sleep. 
Modafinil has been proven effective in treating narcolepsy, shift-work sleep disorder and obstructive sleep apnoea with residual excessive sleepiness despite optimal use of continuous positive airway pressure (CPAP). 
Where to Buy Adrafinil
First of all, it does not currently have FDA approval in France or the United States. But you can purchase it both in powder or capsule form.
It is available for purchase on:
- Nootropics Depot
What Does Adrafinil Cost?
Costs vary, as does quality, but most suppliers seem to sell it for less than $1 per pill.
For example, Amazon.ca sells 150 tablets for CDN$ 124.99. 
What Are the Adrafinil Alternatives?
Fluorenol is a wakefulness-promoting agent that targets similar receptors in the brain as Adrafinil but has a shorter effect period. 
Directions For Taking Adrafinil
The recommended dose is one to two tablets (300-600 mg) twice a day or as prescribed by a medical care practitioner.
The effects take from 40 minutes to two-three hours to appear, and they can last for over a period of days.
For treating narcolepsy, the dosage is 600 mg twice daily, preferably in the morning and at midday.
Generally, you should take it three times a week for no longer than five months. Bear in mind that people no longer use it due to the availability of Modafinil.
Do note that you should avoid taking it for more than 5-10 months as it could lead to addiction due to its dopamine-increasing capabilities. 
Adrafinil and Weight Loss
It is important to note that it may have a slight appetite suppressant effect on some individuals. 
It is noteworthy that, among nootropics enthusiasts, it is well liked. The Reddit /r/nootropics community has over 117,000 subscribers, with many posting positive reviews of Adrafinil.
Many claim that it feels like being hyper-focused on work, with no interest in distractions.
Some claim it does nothing for them. The fact that the FDA has not approved it makes it difficult to know if you’re getting the real deal.
Is Adrafinil Safe?
Therefore, as it is not regulated as a substance in the US, it’s hard to know just what you’re buying. It is, at best, effective (with the potential side effects above) and at worst ineffective or damaging to your health.
Most importantly, it can also cause strain on the liver, as it breaks down there and raises enzyme levels. People with liver issues should avoid taking it. In addition, it could potentially strain your heart, so it’s best to not take it if you have heart problems.
Reviewers on Amazon.ca, nootropicsdepot.com, and the Adrafinil reddit pages, range from “I love it!” to “it does nothing for me” with plenty of reviews in-between, with complaints ranging from bad taste to a funky urine odor.
Who Uses Adrafinil & Modafinil?
Nootropics enthusiasts include doctors and shift workers who must remain alert over long periods of time.
Students also sometimes use nootropics to enhance their studying capacity before exams.
What Does Using Adrafinil Feel Like?
Users report heightened awareness and focus without amphetamine-like jitters. Distractions become minimized and task completion feels very important.
Is Adrafinil Addictive?
While it has fewer negative side effects and addictive qualities than comparable stimulants like cocaine, recent studies indicate that it may be subject to abuse and addiction.
So be careful and pay attention to symptoms of dependency. As we’ve already mentioned, the FDA has not approved it and, as such, it is not regulated. Proceed with caution with any drug that purports to alter your brain chemistry.
Adrafinil Pros & Cons
- Its nootropic effects fairly well-documented.
- Improves alertness and focus.
- Long half-life.
- Can also function as an antidepressant and anxiolytic.
- It can help better users’ physical performance.
- It could cause liver issues.
- A long list of side effects is associated with it.
- It can imbalance your sleep to the point of insomnia.
What Users Are Saying
“It simply works, and it works amazingly. I constantly use it during high pressure periods at work, and it helps me stay focused and get stuff done! 10 out of 10 :)”
“I tried this product to help ease me off my medical prescription for ADD. (I am in between insurance plans and the out of pocket was too high). I had an easy transition off of my prescription meds and feel that the product has worked just as well to help me focus day to day.”
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“I was yawning the whole day I first took this product. Tried it for a few more days with no affect.”
The Bottom Line – Does Adrafinil Work?
Will it boost your concentration and cognitive support? Well, it’s wonderful to see that some actual research and science backs this product. We also appreciate that it’s easy to buy via online stores like Amazon.ca. But the user remarks we saw on the web discourage us, some of which said that the drug does not work at all.
If you need to boost concentration, wakefulness and energy levels, we suggest adding a supplement that documented science backs but also lots of positive user comments and testimonials support.
Among the best products we’ve seen this year is one called Burn HD. It contains a unique ingredient combo that has shown solid results when it comes to igniting metabolism and heightening energy levels. While we didn’t see any negative remarks about side effects, we did spot an assortment of positive user comments indicating weight-loss.
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