Updated: 04/18/2017 - Site operated by Leptigen

Alphamine Review - Does This Thermogenic Powder Really Work?

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  • Rating: 2.8. From 46 votes.
By Summer Banks Apr 25, 2017

You want to lose weight with a product that works, not just says it will work. In my never-ending search to discover the best diet product, this week I reviewed Alphamine. We took an in-depth look at the side effects, ingredients, scientific research and level of customer care. Additionally, we scrutinized hundreds of user comments and testimonials. Then, we summarized and refined to give you the info you need.

Alphamine Readers: Click here to find out why we're giving away samples of our product, Leptigen.

What is Alphamine?

To start, Alphamine ingredients are choline bitartrate, alpha-hydroxyisocaproic acid, eucommia ulmoides extract, olive leaf, caffeine anhydrous, nelumbo nucifera seed, yohimbe bark and higenamine. [1] [2] Add one scoop to water, drink 15-30 minutes prior to breakfast and supposedly it increases fat loss and boosts metabolism.[3]

Alphamine is made by Physique Enhancing Science and has been available since 2012. The supplement is sold on the official website and through trusted retailers. We like that it contains a few natural ingredients and the reasonable price, but read on…

Questionable Ingredients – “Proceed With Caution?”

The first thing we considered with Alphamine ingredients was the potential for health issues. “After taking a close look at the label, we noticed that it contains higenamine,” said our Research Editor. “In some cases, it could lead to adverse reactions.” [4]

  • One customer revealed, “My 18 yo son had an anxiety attack for 2 days. ”
  • According to the Department of Health and Sport Science, University of Memphis, “a higenamine-based dietary supplement…results in a increase in heart rate.”[5]

Reported Side Effects – “Something to Notice?”

According to the customer feedback we found, Alphamine side effects were a concern.

  • One user stated, “Did not feel anything besides becoming nauseous and light headed.”
  • Another dieter commented, “Alphamine may even live up to its claims if used as directed, but the the side effects, specifically nausea, are simply too severe for me.”

Our extensive research has shown that if any part of a supplement is concerning, like the occurrence of negative side effects, long-term success is reduced. So, if dieters are complaining about adverse reactions while taking Alphamine, it may be time to consider an alternative.

The Science Behind Alphamine – “Clinical Proof?”

We picked apart the Alphamine website looking for studies used to show it helps with burning fat. What we did notice was it contains caffeine; which could boost metabolism. Unfortunately, the findings don’t link to this formula. At DietSpotlight, solid science backing claims is a critical part of the review process. When there’s none, we start to become skeptical.

The Bottom Line – Does Alphamine Work?

So, is it time to run out and buy Alphamine? Well, we like the low price and that we found a few positive comments, but the lack of research backing the claims leaves us concerned. We’re also a bit hesitant about this one because of reports of negative side effects and the questionable ingredient.

If you would like to drop those extra pounds, we suggest going with a supplement containing clinically-tested ingredients and isn’t linked to harmful side effects.

Among the best products we’ve seen this year is one called Leptigen. The supplement contains clinically-tested ingredients, that have been shown to help ignite fat loss and accelerate metabolism. There’s no chatter about harmful side effects and dieter feedback reveals people are seeing solid results.

Also, the makers of Leptigen are so confident in their product they’re offering a Special Trial Offer, which is a good sign.

Previous Alphamine Review (Updated June 16, 2014):

Alphamine: What You Should Know

Stores like GNC offer all kinds of health supplements, multivitamins, energy bars, muscle building powders, and diet pills. Nowadays you can even access GNC online. One product you will find on this website is Alphamine powder. It goes for a retail price of $59.99, but may be on sale. It is one of various weight loss supplements available at this point. It comes in fruit punch flavor, and is simply mixed with a glass of water, and then consumed. A single container is a one-month supply.

Alphamine Ingredients:

  • Alphamine FIT Matrix 1567.00 mg
  • Citric Acid
  • Natural and Artificial Flavors
  • Silicon Dioxide
  • Sucralose
  • Acesulfame-K
  • Beet Juice Concentrate Powder

Product Features

Alphamine is touted as a fat igniting technology. This powder formula can be used daily to assist with weight loss, appetite suppression, and improving mood. It is described as an innovative stimulant system with a LBM preservation system. It contains “revolutionary” hardening agents, and works as a selective beta-agonist. With regular use, this formula is supposed to improve thermo genesis, so your body will burn off calories and fat more rapidly. There is no mention of a refund guarantee with Alphamine powder.

The ingredients for Alphamine powder are not really elaborated on. However, it is revealed that this supplement contains an Alphamine FIT Matrix of 1567.00 milligrams. This matrix assists by increasing thermo genesis, enhancing mood, and suppressing hunger. As far as other key ingredients are concerned, there are none. Just so you are aware, Alphamine could lead to some side effects. For instance, some people have experienced rapid heartbeat and jitteriness. Therefore you might want to speak with a professional before trying this type of supplement.

Alphamine Advantages

  • Some user testimonials are posted on the GNC website.
  • Minimal ingredients appear to be used in Alphamine powder.
  • This product comes in fruit punch flavor, which some people will appreciate.

Alphamine Disadvantages

  • Very minimal information is provided on Alphamine.
  • This product does not suppress appetite.
  • The cost of this powder formula is $59.99.
  • Unfortunately this product may cause unwanted side effects.
  • There are more convenient pill formulas available to assist with weight loss.

Alphamine Conclusion

After reviewing a few different websites that offer Alphamine powder, it is clear that some people have found this supplement useful for weight loss or toning up. It is nice to see that there are some customer testimonials out there supporting this product. Then again, this does not mean Alphamine is safe and effective for everyone. As you may have noticed, this powder contains an Alphamine FIT Matrix, which is a little vague. After all, this matrix could contain all kinds of stimulants and other substances. This is why it is wise to proceed with caution.

Alphamine Questions & Answers:

We sorted through hundreds of user reviews about Alphamine to craft this useful FAQ.

What are the side effects of Alphamine?

Alphamine side effects may include increased appetite, anxiety and nervousness, and insomnia. [1]

What are the ingredients in Alphamine?

Alphamine ingredients include choline bitartrate, alpha-hydroxyisocaproic acid, eucommia ulmoides extract, olive leaf, caffeine anhydrous, nelumbo nucifera seed, yohimbe bark and higenamine. [2]

Does Alphamine work?

There aren’t any clinical studies to support the idea that Alphamine works for weight-loss.

If you’re looking for a supplement with clinically tested ingredients, you may want to take a gander at Leptigen.

How much does Alphamine cost?

You’ll spend $59.99 on a container with 84 servings.

What is Alphamine’s BBB rating?

This company is not accredited by the BBB.

How should I take Alphamine?

Add a single scoop to four to five ounces of water. Drink 15 to 30 minutes before breakfast. If needed, repeat five hours later.

Can I take Alphamine if I have a health condition?

If you have a health condition, talk with your doctor to make sure you are healthy enough to use this supplement.

What do users like about Alphamine?

Users like that you can find it in multiple flavors.

What do users NOT like about Alphamine?

Some users complained about Alphamine’s taste, even though there were multiple flavors to choose from. Others worried about side effects.

How do I contact the Alphamine customer service department?

You can get in touch with the Alphamine customer service department by phone at 1-888-885-0195. They are available between the hours of 9 am to noon EST and 1pm to 4pm EST. You can also fill out the contact form.

Is Alphamine available in multiple flavors?

Yes. You can find it in cherry lemonade, raspberry lemonade, and fruit punch flavors.

Does Alphamine come with a guarantee?

Yes. If you are not happy with the product, there is a 100% money-back guarantee.

Do you know of any special deals or discounts on Alphamine?

We couldn’t find any deals or discounts on Alphamine, but for anyone who is interested, there is a Special Trial Offer of Leptigen. It a weight-loss supplement made with clinically tested ingredients. Click here to give it a try.

Alphamine Side Effects:

Alphamine is a thermogenic used as a pre-workout supplement. It supposedly helps with fat burning. Side effects are rare, but we found that some users reported adverse reactions with this one. [1]


“But the side effects, specifically nausea, are simply too severe for me.“    Erica


“It left me jittery.”    Melissa


“I’ve tried this product and it’s not for me. It makes me feel horrible and has worked my heart into overtime.”    Tanisha


“I tried 2 scoops and got jittery and nauseous.”    Emily


“Speeds up the heart rate! Alas, I had to quit using it as I was starting to get headaches from it.”    Paul


“I did have anxiety increase. PES has a form of yohimbe that creeps up on you. I did feel fatigued very often.”    Trey


“Be warned though, you will poo your brains out within 15. I also encountered the occasional twitch due to lack of sleep.”    Evan


“The main side effect I got from this was a constant “numbness” on my mind. I lost pretty much concentration FOR EVERYTHING. When headaches returned, it was like a piercing feeling.”    Andre


“Did not feel anything besides becoming nauseous and light headed.”    Michaela


“I just felt jittery and it also made me sweat which was uncomfortable.”    Jessica


If you’re looking to increase fat burning and jump start weight-loss, it might be time to think about your choices and go with one of the best out there. We’re hearing a lot of buzz about Leptigen, a supplement containing clinically-tested ingredients, backed by positive customer reviews and not associated with harmful side effects.

Click here to get more information about Leptigen.

This solution is designed for athletes to give them energy. With the combination of caffeine and theanine it accelerates energy for a period of time.

Alphamine Ingredients and Supplement Facts

Serving Size: 1 Scoop (2.9g)
Serving Per Container: 84
Amount per Serving % DV
Alphamine Proprietary Blend * *
L-Leucine,L-Camitine-L-Tartrate * *
Choline Bitartrate 1,590 mg *
L-Theanine,Ferula * *
Asafoetida(seed)Extract(95% Ferulic Acid) * *
Caffeine Anhydrous 125 mg *

Other Ingredients: Citric Acid, Natural and Artificial Flavors, Silicon Dioxide, Sucralose, Acesulfame Postassium, and Beet Juice Concentrate.

We dug deep into the Alphamine ingredients to give you the details you need.

Caffeine Anhydrous

Caffeine anhydrous is a dehydrated form of caffeine. [1]

What is it Supposed to Do?

It is a stronger version of the stimulant caffeine.

Clinical Research

According to a study published in Journal of Thermal Analysis, “Caffeine has been found to display a low-temperatureβ- and a high-temperatureα-modification.”

Clinical research is an important part of the equation when it comes to choosing a diet supplement. You may want to take a look at a product like Leptigen, which is formulated with clinically tested ingredients.

Yohimbe Bark

The bark of a tree native to Western Africa, it is commonly used in medicine and supplements.

What is it Supposed to Do?

It is supposed to help support sexual function, and serve as a treatment for erectile dysfunction., while also helping to improve athletic performance.

Clinical Research

According to a study published in Phytopharmacy: An Evidence-Based Guide to Herbal Medical Products, “Clinical evidence, pre-clinical evidence, mechanisms of action, interactions, contraindications, information about adverse effects and dosage of Yohimbe (Pausinystalia johimbe). Yohimbe is recommended for erectile dysfunction (ED) in males and loss of libido in females; it has also been advocated as an aid to weight loss and to enhance exercise tolerance and muscle development in bodybuilders.”

Olive Leaf

This is the leaf of the olive tree.

What is it Supposed to Do?

It is supposed to help address blood sugar levels and enhance insulin activity.

Clinical Research

According to a study published in Planta Medica, “The hypoglycemic activity of this compound may result from two mechanisms: (a) potentiation of glucose-induced insulin release, and (b) increased peripheral uptake of glucose.”

Choline Bitartrate

Choline is similar to the B vitamins, and can be made in the liver. IT can also be found in foods, including muscle meats, liver, wheat germ, eggs, peas, nuts, and beans.

What is it Supposed to Do?

It is used to treat a number of conditions, but athletes use it to delay fatigue in endurance sports.


This is a chemical found in a number of plant species.

What is it Supposed to Do?

It is a stimulant that’s thought to be the next ephedra, and as such it’s thought to boost the metabolism so it is easier to lose weight. [2]

Nelumbo Nucifera Seed

These are lotus flower seeds.

What is it Supposed to Do?

It has anti-obesogenic properties, and anti-diabetic properties, but does not necessarily help the body burn more fat.

Alpha-Hydroxyisocaproic Acid

This is the end product of leucine metabolism in muscle and connective issue.

What is it Supposed to Do?

It is supposed to help delay the onset of muscle soreness after physical activity.

Eucommia Ulmoides Extract

This comes from a plant traditionally used in Traditional Chinese Medicine.

What is it Supposed to Do?

Though there are no human trials, there animal evidence suggests this supplement may help lower the blood pressure.

Is There Anything Out There That TRULY Works?

We have our eye on a supplement that fits the bill. Leptigen, which is formulated with ingredients that HAVE been clinically tested, may be a good option. All customers can take advantage of a Special Trial Offer, currently available. Click here to give it a try.

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Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Leptigen, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 2.8. From 46 votes.
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