Updated: 04/18/2017 - Site operated by Leptigen
By Summer Banks Apr 15, 2017

Appethyl is a dietary supplement that has really started making a name for itself.  So, we took an in-depth look at the side effects, ingredients, and clinical research. Hundreds of comments were taken to heart. Then, we refined and summarized to give you the bottom line.

What is Appethyl?

Firstly, Appethyl isn’t a meal replacement plan, but it is designed specifically to suppress appetite. The product is supposed to support weight-loss by utilizing thylakoids; small organelles found inside green plant cells that can slow down the digestion process. [1] It is easy to take; all you need to do is mix one scoop of the powder with water and take it before a meal high in fat. [2] Only one serving is necessary per day. There is also a capsule option, which works as a nice alternative to the grainy powder.

Appethyl, which was introduced in 2013, won the award for “Best New Functional Ingredient” at the 2013 NutraCon conference, and it is now available in health stores, on its official website, and online on Amazon and similar retailers. We like the natural ingredient (thylakoids) [3], and it seems like a fairly easy product to take, but read on…

Price – “Expensive?”

The first issue we found in user reviews were reports of a big price tag for Appethyl. “You may see some appetite reduction if you take the supplement as directed,” said our Research Editor, “But, it costs almost $60.00 for a month’s supply.”

“It is very expensive,” stated a customer.

Although there was a concern with price, we found reviews mentioning the expense, but also telling others they noticed results.

“Very expensive product for the results I got,” one user said.

Efficacy of Appethyl Ingredients – “Seeing Results?”

As with some dietary supplements, the promised results don’t always come true for everybody. Upon sampling user reviews, we started noticing a theme. “I’ve been taking Appethyl faithfully as directed. My appetite has not changed, nor has the fat started shrinking as it promises.”

“I know everyone is different, but I didn’t have that much luck,” said another.

After further reading, it seems these negative reactions don’t stand alone.

“I could feel results after the first 24 hours. My cravings for salty foods and sweets subsided after the first day,” stated a customer.

Another stated, “I have been on this 4 a month i have stayed on my diet with no problem.”

Although Appethyl shows a lot of promise, even one drawback to the product can hurt its long-term success. [4] In this case, the pricing demands a significant commitment on the part of the user. If the cost sits too high for most people to commit to for very long, the chances of it helping them keep weight off aren’t great.

The Science – “Researched?”

The whole concept of thylakoids is rooted in science, and it appears that the effect on human appetites has been studied. [5] Scientific research is not an issue here, but the relationship of the supplement to weight-loss might be. Appetite suppression is only one small part of the equation, and someone spending money on Appethyl may need more than that.

The Bottom Line – Does Appethyl Work?

Appethyl is certainly an exciting new product, and we are looking forward to seeing how it’s used in the future. For now, though, the product only focuses on appetite suppression, which is a relatively small slice of the pie. Furthermore, Appethyl is quite expensive and doesn’t work for everyone. These are more than enough to leave us with some reservations about recommending it.

We recommend two things in a supplement if you still need to shed some pounds – a good value for your money and a strong formula.

Among the best products we’ve seen this year is our product called Leptigen. It’s a blend of four ingredients. All clinically-tested with results found in publications such as the Journal of Medicine and the journal Obesity.

Also, we’re so confident that you’ll love our supplement that we’re offering a Special Trial Offer;, which is a good sign.

Appethyl Readers: Click here to find out why we're giving away samples of our product, Leptigen.

Previous Appethyl Review (Updated June 25, 2012):

What You Should Know About Appethyl

Appethyl is an ingredient most dieters will not be familiar with because it has not yet hit the market. Green Medical AB is the company behind the ground-breaking spinach extract. The extract was honored to be named one of the finalists for the NutraCon NutrAward as of February 2013. Green Medical Abs official website explains the extract as a derivative of spinach that decreases appetite, reduce waist size and improve glucose and cholesterol levels. There is mention of clinical studies, but no links to such studies. We were able to find some studies on the active portion of Appethyl and appetite.

Appethyl: List of Ingredients

  • Thylakoids

Appethyl: Product Features

Thylakoids are nothing new. When we researched the spinach derivative we found studies from the 1970s, but current studies are also available. According to one study completed in 2009, thylakoids added to one high-fat meal sparked changes in the body that helped ease hunger after the meal. The changes took effect between two and six hours after the meal was consumed. Insulin levels were also affected in a positive manner – reducing insulin reaction to the meal. We found additional, similar studies from 2007. For a relatively unknown weight loss ingredient, thylakoids have a strong clinical history. We are unsure why this ingredient has not been promoted as an appetite suppressant to date, but Appethyl is poised to break the market and make lots of money as the primary source of this (soon-to-be) patented ingredient.

Appethyl Advantages

  • Clinically proven to suppress appetite.
  • Works hours after consumption.
  • Derived from all-natural spinach.
  • Patents pending.
  • Fills a gap in the weight loss market.

Appethyl Disadvantages

  • Not currently used in any weight loss supplements as of February 2013.
  • Does not address increasing metabolism.
  • No large-scale clinical studies have been completed.


Appethyl is an amazing ingredient that could be the answer to weight loss issues for millions of people. Hormonal changes in the brain sparked by Appethyl suppress appetite. The ingredient works as a prebiotic and helps maintain healthy insulin levels. When this ingredient hits the weight loss market, we can expect a long list of new supplements touting the weight loss benefits of Appethyl, but controlling hunger is just one aspect of supplemental weight loss. The best formulas will contain other clinically proven ingredients like caffeine and green tea. We’ll have to wait and see just how the Appethyl story ends or, in this case, begins.

Appethyl Questions & Answers:

We picked apart hundreds of user comments about Appethyl into this helpful FAQ.

What are the side effects of Appethyl?

Some Appethyl side effects may include upset stomach, nausea, vomiting and irregular bowel movements, as shown in some customer comments.

What are the ingredients in Appethyl?

Appethyl ingredients are vitamin A, vitamin K, calcium, iron, spinach extract and citric acid. [1]

Does Appethyl work?

There’s mention of science backing the effectiveness of thylakoids, but that’s just one ingredient. There is more than this to choose from.

Dieters may consider replacing Appethyl with a supplement like Leptigen, which contains clinically tested ingredients.

How much does Appethyl cost?

Appethyl costs $24.99 for one canister. If you purchase three, the price is $74.97 and five runs $124.95. You will receive free bottles with additional purchases.

How should I take Appethyl?

You should mix one scoop of Appethyl into your favorite beverage, smoothie or protein shake once per day. Each container consists of 15 servings.

Can I take Appethyl if I have a health condition?

Women who are pregnant or nursing, those with health conditions of any kind, people under 18 years of age or anyone taking prescription medications should consult with a healthcare provider prior to starting a weight-loss supplement, including Appethyl.

What do users like about Appethyl?

We found that some dieters liked the small price tag of Appethyl and that the supplement is available on the official website.

What do users NOT like about Appethyl?

Some users didn’t like the taste of Appethyl and the side effects. Additional concerns related to the supplement not helping users lose weight.

How do I contact the Appethyl customer service department?

You can contact the Appethyl customer service department by calling a representative at 1-888-349-0483 or by using the feedback form.

Do I need to change my diet on Appethyl?

No, you don’t need to change your diet on Appethyl. The company does recommend using the supplement prior to a meal containing fats or oils. [2]

How many calories are in Appethyl?

Each serving of Appethyl contains 10 calories.

Does Appethyl come with a guarantee?

Yes, Appethyl comes with a guarantee. You have 90 days to return the supplement for a full refund.

Do you know of any special deals or discounts on Appethyl?

There are special deals and discounts on Appethyl. If you sign up for automatic delivery, you will receive a 10% discount on your order and if you purchase multiple bottles, you get one free. However, our readers have been going bananas over the past few months taking advantage of Leptigen’s Special Trial Offer, which is just the cost of shipping and handling. Click here to give it a shot.

Appethyl Ingredients and Supplement Facts

Serving Size: 2.5 grams
Serving Per Container: NL
Amount per Serving % DV
Calories 10 *
Vitamin A 175 IU *
Vitamin K 28 mcg *
Folic Acid 10 mcg *
Calcium 75 mg *
Iron 3 mg *
Lutein 700 mcg *
Zeaxanthin 20 mcg *

Other Ingredients: None

We dug deep into the Appethyl ingredients to give you the details you need.


Appethyl is a patented blend of spinach thylakoids. These are found in the chloroplasts in the plant cells that contain chlorophyll that allow photosynthesis, or energy production to take place within the plants. Without them, the plant wouldn’t have anywhere to attach the chlorophyll, so it wouldn’t be able to produce energy and it would die. [1]

What is it Supposed to Do?

The thylakoids in plants are supposed to help suppress appetite. It works by promoting the release of cholecystokinin, a hormone produced by the gastrointestinal tract. This increases feelings of fullness, while also decreasing the desire for food. This happens as a result of the hormone’s action on the hypothalamus. This is the part of your brain that controls hormone secretions, energy expenditure, and feeding behavior. Foods high in thylakoids also help lower the amount of insulin your pancreas excretes after a meal. This helps prevent fat gain and health risk by keeping insulin levels lower.

Clinical Research

According to a study published in Phytotherapy Research, “The satiety hormone cholecystokinin was elevated, suggesting this hormone mediates satiety. Leptin levels were reduced, reflecting a decreased fat mass.” [2]

Clinical research is a vital part of the equation when it comes to choosing any dietary supplement. You may want to considering using a product like Leptigen, which is formulated with clinically tested ingredients.

Is There Anything Out There That TRULY Works?

We have zeroed in on one supplement that gets the job done. Leptigen, which is made with ingredients that HAVE been scientifically tested, could be a good choice. All customers can take advantage of a Special Trial Offer, currently available. Click here to give it a try.

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Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Leptigen, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 3.9. From 75 votes.
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User Comments

13 Comments on "Appethyl Review"


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It seems to work for hunger and sweets BUT I seem to have a ache in my side
for a long time since taking the Appethyl upon test they say I have a fatty liver and every time I drink the Appethyl I notice the ache in my side .
has anyone else experienced any side affects?


I heard appethyl tablets reviewed on the radio yesterday by a Dr. so I started searching online I can’t seem to find the tablets anywhere. Can you tell me where I can purchase


Where can I buy appethyl tablets

Your Name

ProSpinach.com has capsules


i live in a very remote place so i need to know where they sell appethyl


GNC has appidex. They claim that it has appethyl in it. I read the first mag article. I’m going to make the spinach smoothie and add the appidex and yogurt. I just found the hydroxycut appetite control at Walgreens. It is a powder. I am on my way to pick it up. My birthday is in March and I want to have dropped 2 dress sizes. Of course I’ll work out, eat right and yada-yada-yada but for right now this is my motivation!

Debi Bainter

You need to update as new report out and it came back as being like a gastric bypass without surgery from “FIRST” 1/19/15. Great report out of Sweden. Hydroxycut Appetite Control. Can’t wait to try!!!!!!


Do you appeythl is like the gastric bypass ?


Is there a trial offer available and if not how/where can I order it?

Kris omakkey

Will it be in US soon?


When will app ethyl become available here? I read an article that it is available in Scandinavia now. Is there some way to purchase it from a company there?


Now available in walgreens


Is Appethyl available in Canada yet?