Updated: 10/17/2017
By Summer Banks Sep 22, 2017
30comments

BiphedAdrene isn’t your grandmother’s diet product. We delved into the ingredients, side effects, and scientific research. We also dug into hundreds of consumer testimonials. We then refined and condensed to give you the info you need.

BiphedAdrene Readers: Click here to find out why we're giving away samples of our product, Burn HD.

What is BiphedAdrene?

First off, BiphedAdrene is a fat burner containing yerba mate extract, [1] caffeine, arbutin extract, phenylethylamine, damiana leaf extract, methylamine, cayenne powder, cutch tree extract, 5HTP, l dopa and theobromine. [2] The recommend dose is one capsule per day, which supposedly aids in weight-loss. One of the benefits of the supplement is that it’s easy to use.

There is no available information as to when Generix Laboratories introduced BiphedAdrene. We noticed that the supplement could be found on the official website, a good choice. You can also buy the product on trusted retail sites. We do like that there are some positive customer comments, and the company has a favorable BBB rating but read on…

Ineffectiveness – “No Weight-Loss?”

The first negative pertains to BiphedAdrene ingredients being ineffective, despite the fact that some clinical research on humans has shown a boost in energy from the caffeine. “When a company promises rapid weight-loss the dieter expects to see results,” says our Research Editor. “In the case of this supplement, the effects are just not what the buyer wants them to be.”

“I used this along with my diet and exercise program. I saw no difference the 1 month I took BiphedAdrene. I lost more weight without this product,” said a customer.

“I took this pill as directed and I gained weight. I found myself to be hungrier than ever! I cut out carbs and left food on my plate even though I was still hungry and I still gained. I was working out and tried so hard thinking that it will work. Never did,” commented a dieter.

Though some people did not see the loss they were looking for; others saw a few changes. As one put it, “Can I still eat? Sure. But I don’t have the urge to overdo it.”

BiphedAdrene Customer Testimonials

BiphenAdrene Side Effects – “Watch Out!”

According to numerous comments, BiphedAdrene side effects may cause some issues, with a few coming as physical manifestations. “I have been using this product for 4 days now, and I have been experiencing bad headaches, jittery, [3] nausea and sleeplessness,” reported a customer.

“I feel bad. My heart starts racing,” said a consumer.

During our research, we also came across some people who didn’t have any issues. One customer stated, “It does not make me jittery or nervous.”

Based on our research and look at the effects of a stimulant on humans, if a supplement causes a single problem, like side effects, this could impede long-term success. If BiphedAdrene causes reactions, there are concerns.

The Science – “Is it Legit?”

According to the official website, BiphedAdrene will boost energy, improve mood (which is not supported by science [4]) and control appetite, but there’s no published clinical research linking the formula to weight-loss, aside from proof that caffeine can boost metabolism. [5] At DietSpotlight, we deal in science to prove claims. If there are no studies, we walk away.

Also: read our Burn HD Weight-Loss Kit review »BiphedAdrene Ingredients

The Bottom Line – Does BiphedAdrene Work?

Well now, what can we say about BiphedAdrene? We like the favorable BBB rating and the money-back guarantee, but we have doubts about recommending it because of the lack of scientific research supporting the weight-loss claims. Plus, there are customer reviews are talking about negative side effects and limited results.

If you’d like to lose the fat, we recommend going with a product delivering good results and a great price. It’s also important to choose a supplement with no reported side effects.

Among the best products we’ve seen this year is one called Dietspotlight Burn. The four-ingredient proprietary blend has been shown in studies to help ignite metabolism and promote fat loss. There’s no talk about those side effects associated with extreme stimulants and reviews on the web indicate that people see exceptional results.

Also, the company behind Dietspotlight Burn is so confident in the supplement; they’re offering a special trial offer, which is a good choice.

Previous BiphedAdrene Review (Updated November 5, 2014):

BiphenAdrene - What You Should Know

Biphedadrene is a weight loss pill on that has made a miraculous return to the market in recent months. The product apparently disappeared for a while due to an “overwhelming demand” for it on shelves. If you are looking for a product to help you burn fat and suppress your appetite while you are following a diet and exercise routine to help you reach your weight loss goals even faster, read this review to find out how this product compares to others on the market today. It should be noted that while dieting and exercise aid in weight loss, caffeine takes a role in fat loss as well. Individual studies found that caffeine can help elevate the metabolism by increasing thermogenesis, which allows your body to generate energy and heat to burn off calories.

List of Ingredients

Not available.

Product Features

Biphedadrene does not provide a full ingredient listing on their website to help people analyze what they are getting before they buy it. They advertise it to be an amphetamine like compound, which means it will boost your metabolism to help you burn more fat and suppress your appetite, but it could have some side effects, such as insomnia, increased blood pressure and heart rate, and jitters. Other products, with ingredients like Forskolin, claim to help with blood pressure and can aid in weight loss. There is an extreme warning listed on the product, that says you should use caution while using this product as part of a balanced diet and exercise routine. While we do like that it promotes a healthy diet and exercise program, we tend to shy away from it because it indicates it may not be safe. A 60 capsule 15 day supply of this supplement will cost you $75 plus shipping and handling costs, where a 30 day supply will cost you $135. A 60 day supply will cost you $270, and give you an additional month’s supply for free, thus saving you $135.

BiphenAdrene Advantages

  • Biphedadrene has ingredients that will help you burn fat and suppress the appetite.
  • This product seems like it has the potential to have very negative side effects.

BiphenAdrene Disadvantages

  • Biphedadrene is an expensive product for many people.
  • This product does not provide a free trial.
  • There is not a full list of ingredients available for review.
  • We are not able to find any evidence of clinical research to support this product.
  • There are no customer testimonials to support this product.

Conclusion

Biphedadrene may very well produce weight loss results, but individual results will vary based on the type of diet followed, the amount of exercise you do, and the overall amount of weight you have to lose. Given that we are not able to closely examine the ingredient list, and there is an extreme word of caution right there on the product packaging, we advise you to proceed with caution when using this supplement. It is definitely not safe for women who are pregnant, nursing, or trying to become pregnant. It is not safe for children under the age of 18, and likely is not a good option for those who have heart or other health conditions.

BiphedAdrene is a stimulant-based program that includes a phenylethylamine complex and thermogenic compound. One common ingredient between the two formulas is caffeine. Proprietary blends are used to protect ingredient amounts, so there's no means of supporting claims with clinical research.

BiphedAdrene Ingredients and Supplement Facts

Serving Size: 1 Capsule or 1 Tablet
Serving Per Container: 30
Amount per Serving% DV
BiphedAdrene 1489mg*
- Trimethylxanthine**
- Arbutin**
- Alpha-Phenylethylamine**
- Phenylethylamine**
- Theobromine**
BiphedAdrene 2489mg*
- Llex Paraguariensis**
- Guarana Extract**
- Methylxanthine**
- Turnera Diffusa**
- Capsaicin**
- Cutch Tree Extract**
- 5-HTP L-Dopa**

Other Ingredients: Microcrystalline cellulose, stearic acid, magesium stearate, silicon dioxide, croscarmellose sodium, polyvinyl alcohol, polyethylene glycol, erythrosine aluminum lake, talc, titanium dioxide, gelatin, rice flour

We dug deep into the BiphedAdrene ingredients to give you the details you need.

Yerba Mate Extract

Yerba mate is a plant, and the leaves are used to make the extract, which is used in a number of medicinal applications. In Brazil and Argentina, it is used to make a popular tea.

What is it Supposed to Do?

According to WebMD, yerba mate is used “a stimulant to relieve mental and physical tiredness (fatigue), as well as chronic fatigue syndrome (CFS). It is also used for heart-related complaints including heart failure, irregular heartbeat, and low blood pressure. Some people use mate to improve mood and depression; to relieve headache and joint pains; to treat urinary tract infections (UTIs), and bladder and kidney stones; for weight loss; and as a laxative.” [1]

Clinical Research

According to a study published in Medicinal and Aromatic Plant Science and Biotechnology, “Yerba mate has been shown to inhibit the formation of advanced glycation end products (AGEs), with an effect comparable to that of two pharmaceutical grade AGE inhibitor drugs.”

5HTP

A chemical byproduct of the L-Tryptophan amino acid, this is also produced commercially, using the seeds of an African plant.

What is it Supposed to Do?

According to WebMD, “It works in the brain and central nervous system to increase serotonin. This chemical can affect sleep, appetite, temperature, sexual behavior, and pain sensation.” It is used for sleep disorders, anxiety and depression, migraine and tension headaches, obesity, premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), and attention deficit hyperactivity disorder (ADHD).

Clinical Research

According to a study published in the American Journal of Clinical Nutrition “A reduction in carbohydrate intake and a consistent presence of early satiety were also found. These findings together with the good tolerance observed suggest that 5-HTP may be safely used to treat obesity.” [2]

Damiana Leaf Extract

Damiana is a wild plant that grows in parts of Mexico, Central America, and the West Indies. The leaves and stems are used to make medicine. Historically, it was used mostly as an aphrodisiac, to increase libido.

What is it Supposed to Do?

We found information that said damiana is used for “headache, bedwetting, depression, nervous stomach, and constipation; for prevention and treatment of sexual problems; boosting and maintaining mental and physical stamina.”

Clinical Research

According to a study published in the Journal of Human Nutrition and Dietetics, Damaina may help with weight-loss. “The herbal preparation, YGD capsules, significantly delayed gastric emptying, reduced the time to perceived gastric fullness and induced significant weight loss over 45 days in overweight patients treated in a primary health care context.” However, the supplement used in the study combined damiana with yerba mate and guarana.

Caffeine

Caffeine is a stimulant found in coffee, tea, and soda. It can also be found in supplement form.

What is it Supposed to Do?

Caffeine is supposed to increase mental alertness and boost metabolism.

Arbutin Extract

Also known as bearberry extract, this is a natural skin lightener.

What is it Supposed to Do?

By reducing melanin production, this extract lightens the skin. It is used to treat age spots, freckles, sun spots, and can help even a blotchy skin tone.

Phenylethylamine

Phenylethylamine is a chemical that occurs naturally within the body. It can also be made in a laboratory.

What is it Supposed to Do?

Phenylethylamine is supposed to improve athletic performance, help depression, help weight-loss, and improve mood and attention. It is not suggested in people who have a mental condition of any kind. Experts also agree that it can interfere with surgery.

Methylantine

Methylantine is a caffeine compound.

What is it Supposed to Do?

Methylantine is supposed to increase mental alertness and boost metabolism.

Cayenne Powder

Made from the red cayenne chili pepper, this adds spicy heat to food.

What is it Supposed to Do?

Cayenne pepper is supposed to boost metabolism.

Cutch Tree Extract

This comes from the seeds and bark of an Asian tree.

What is it Supposed to Do?

The product labeling suggests this is supposed to boost serotonin levels, but we found no clinical evidence to support the claim.

L-Dopa

This is a precursor to the dopamine neurotransmitter responsible for a good mood. It is derived from the velvet bean, which grows in Africa, India, and the Caribbean.

What is it Supposed to Do?

L-Dopa is supposed to help elevate mood.

Theobromine

This is a chemical found in chocolate. Dark chocolate has more of this chemical than milk chocolate.

What is it Supposed to Do?

It is supposed to produce a stimulant effect similar to caffeine.

When taking a closer look at weight-loss supplements that work best for shedding off pounds, Dietspotlight Burn came across as a unique product with four ingredients clinically shown to help the metabolism run at a faster pace.

BiphedAdrene Scientific Abstracts:

Yerba Mate Extract

Polyphenolic extracts from yerba mate leaves can increase the shelf life and sensorial quality of ground bees and sunflower oil and improve organism defense due to its antioxidant and therapeutic qualities. For pharmaceutical and food industries to commercialize applications, the product needs consistent composition and activity. [1]

5-HTP

5-HTP (L-5-hydroxytryptophan) is said to be the immediate precursor of serotonin. This nutrient has a real and rather a large following who have been advocating over-exaggerated and inaccurate claims about the benefits of treatments of depression and a slew of other serotonin-related diseases. [2]

About weight management, another report has stated significant weight-loss in patients treated with 5-HTP. A carbohydrate intake reduction and a steady presence of satiety were discovered. According to these findings, it has been suggested that 5-HTP may be used for the treatment of obesity. [3]

Damiana Leaf Extract

The herb preparation YGD containing Guarana (seeds of Paullinia cup and), Yerba Maté (leaves of Ilex Paraguayan is), and Damiana (leaves of Turnera diffusa var. aphrodisiac was followed by an elongated gastric emptying time of 58 +/- 15 minutes compared to 38 +/- 7.6 minutes after placebo (P = 0.025). Reductions in body weight were 8 +/- 0.05 kg after YGD in comparison to 0.3 +/- 0.03 kg after taking placebo for 10 days; 5.1 +/- 0.5 kg after PGD capsules. These results were compared to 0.3 +/- 0.08 kg after receiving placebo over the 45 days. In conclusion, the herbal YGD preparation substantially delayed gastric emptying, lowered times of perceived gastric fullness and trigger substantial weight-loss over the 45-day period. This herbal treatment is therefore shown to be one that substantially modulates gastric emptying. [4]

Capsaicin

Reports on the roles of capsaicin when treating obesity, cardiovascular and gastrointestinal conditions, neurogenic bladder, various cancers, and dermatologic conditions. Theories have come to the table to explain these effects. Numerous pharmacological actions are TRV1 independent. It has been determined that further human trials are needed to secure more data. [5]

Theobromine

24 male participants finished six double-blind trials in which they ingested experimental beverages. After, their mood was assessed, and they finished a 2-hour visual vigilance task. At every dose, theobromine had consistently failed to affect attention or mood state (P > 0.05). However, 100mg caffeine substantially reduced lethargy and fatigue and raised vigor (P = 0.006 and 0.011, respectively). According to these studies and upon examining the data, theobromine does not have an influence on mood and vigilance when given in nutritionally relevant doses, despite being very similar to caffeine. [6]

Learn More About Burn HD »
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.

Rating: 3.6. From 49 votes.
Please wait...

BiphedAdrene Customers Also Bought:

BiphedAdrene

Q:
What are the side effects of BiphedAdrene?
A:

Biphed, short for BiphedAdrene, potential side effects may include jitteriness, nervousness, sleeplessness, muscle spasms, irritability, anxiety, upset stomach, nausea, increased heart palpitations and vomiting, according to some people who’ve tried it. 

Q:
What is in Biphed?
A:

BiphedAdrene ingredients are trimethylxanthine, caffeine, α-phenylethylamine, β-phenylethylamine, phenethylamine, theobromine, microcrysalline cellulose, stearic acid, magnesium stearate, silicon dioxide, croscarmellose sodium, polyvinyl alcohol, polyethylene glycol, erythrosine aluminum lake, talc, titanium dioxide, fd&c blue #1 aluminum lake, fd&c #2 carmine aluminum lake, ilex paraguariensis, guarana, methylxanthine, tumera, capsaicin, seratonin, l-dopa, gelatin, rice flour, titanium dioxide, fd&c yellow #5 and fd&c yellow #6.

Q:
How do I know if BiphedAdrene is right for me?
A:

Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients.

Click here to get your sample of our powerful fat burner today.

Q:
What is the active ingredient in BiphedAdrene?
A:

The active ingredient in Biphed is caffeine.

Q:
Does BiphedAdrene work?
A:

There’s no science to back the claims that BiphedAdrene is an more effective weight-loss supplement that others that are stimulant-based. There are studies into caffeine,  but that is found everywhere and doesn’t relate to this formula.

Q:
How much does a bottle of BiphedAdrene cost?
A:

A bottle of BiphedAdrene costs $135 for a 60-day supply.

Q:
How do you take BiphedAdrene?
A:

You should take one purple and one yellow BiphedAdrene capsule prior to your main meal. Each box contains a 60-day supply. The company recommends not exceeding four capsules in a 24-hour period.

Q:
Can I still drink coffee on BiphedAdrene?
A:

No, you can’t drink coffee on BiphedAdrene. The company recommends not consuming additional caffeine while taking this supplement.

Q:
How much caffeine does BiphedAdrene contain?
A:

Each serving of BiphedAdrene contains 260mg of caffeine.

Q:
Does Biphed come with a guarantee?
A:

Yes, BiphedAdrene comes with a guarantee. You have 30 days to return the supplement for a full refund.

When searching for weight-loss supplements that are truly effective and not gimmicks, search for clinically tested ingredients from a company that offers amazing results. Dietspotlight Burn is one we’ve speculated and works efficiently.

30 BiphedAdrene Reviews

  • BiphedAdrene
    Your LisaName

    I would like to know if you can take this if you are on medication. Thanks Lisa Anderson

    • Cameron (Editor)

      Hi, Lisa. Use caution if you are on blood pressure medication. Ask you doctor if this formula would interfere with your prescriptions.

  • Would this affect drug test results?
    Di

    Would biphedadrene cause a positive for amphetamine on court ordered random UA’s or mouth swab?

    • Shanda

      I would hope not, considering that would make it a “controlled substance” which would be a schedule 2 narcotic.

      • Evy Vaudrin

        i work in a clinic and have access to urine drug screening tests and haven’t come positive for amphetamine.

  • Does anyone lost weight without effect?
    carla

    did you lose any weight or did the serious side effects made you quit before you could lose weight

    • LadySpice

      Carla Istarted taking around oct 6 2012 I weighed myself toward mid end of dec n had lost 15 pounds as I stated before if it makes u jittery take half purple n whole yellow n eat within 15 min of taking it. Also limit caffeine intake . I called them n got that info from an operator and it worked.

    • Montana (Editor)

      Hello Carla! Some, but not all, users of Biphedadrene complained of jitteriness, nervousness, sleeplessness, muscle spasms, irritability, anxiety, upset stomach, nausea, increased heart palpitations and vomiting. If you’re looking for a weight loss supplement that comes with little side effects, you may want to give Dietspotlight Burn a chance!

  • leah johnson

    I have taken this for days and it gets sick puking and nausea

    • Camille

      Hi Leah. Please make sure to consult with your physician before continuing to take

      this product and let them know about the side effects you were experiencing.

  • Tammy

    Spent 100.00 on this product. Took as directed. Box empty no weight loss at all not happy

  •  I'm going back to gnc to return this, it's not worth my health.
    Bri (Verified User)

    This is my third day taking the pills and I’m seriously considering calling it quits. You feel the energy boosts after 15 minutes which is great. However, sleep has been difficult and now my symptoms include my limbs tingling (like when circulation suddenly rushes through) and my fingers started moving involuntarily for 5 minutes. I’m 22 years old 5′ 7″ and 200lb. I’m going back to gnc to return this, it’s not worth my health

    • Montana (Editor)

      Hi Bri. We’re sorry you suffered from such bad side effects! You may want to think about switching to a weight loss supplement that comes with little side effects, like Dietspotlight Burn.

  •  Body is reacting differently
    anika (Verified User)

    My heart starts palpitating, i start getting shortness of breath! i cut my intake down to one serving per a day. i’m so freaked out.

  •  It will show good results after two weeks.
    Ali (Verified User)

    I was introduced to biphedadrene by my roommate she gave me 40 pills (20 purple and 20 yellow) I lost 30 lbs in a month. I look so good. It’s not just taking the pills that will get you results you need to diet and exercise. I was hitting the gym 6 days a week for about 3-4 hours at a time. I was also running every morning. My diet was poor not because I was eating bad food but because I wasn’t eating enough to give my body the protein it needed for my muscles with all that work I was doing. Negative side of effect for sure is my insomnia. I can seem to be able to sleep for a couple nights and then one day I’m so exhausted I just crash sleeping for hours in the middle of the day. But I go to the gym late around 10pm and leave at 2 or 3 am. I stopped taking them for a couple months but just bought a new box a couple days ago. I just take the pills right before I work out once a day that’s it so they last me a good amount of time. I’m a college student living on my own paying my own bills with a 2 jobs and I can afford them. They’re worth it!!! But give it 2 weeks to start seeing results and a month for others to see it. Exercise and diet or else you won’t progress as dramatically

    • Your Name

      Lost 30 lbs in a month. Ok!

    • Your Name

      Pretty sure it was hitting the gym and running 6 days a week that made u lose weight not the stupid pills.

  •  I love it !
    Ben (Verified User)

    I love it its like adderall to me I have tons of clean energy energy from it .. It also reminds me of the old redlines vpx drinks

  •  2 weeks no results !
    Tammy (Verified User)

    Paid over 100. For this cause of advertisements been talking it for over 2 weeks haven’t lost a pound and I walk allot I also have hypothyroidism tale medicine for that haven’t had any side effects at all days money back guarantee on box hope it’s true still have receipt from gnc so now what

  • Facing side effects.
    kathy (Verified User)

    i just started taking biphedarene 2 days ago.i need to lose 80 pounds. i’m going to be pissed if this doesn’t work. i paid 100.00 at gnc for this. i pray it works without giving me headaches.

  •  Never felt better
    Sarina (Verified User)

    So far I would like to say that these pills work. I mean as long as you’re taking as directed you shouldnt have a problem. I started taking these two days ago and I’m already seeing a difference in my appetite, weight, and even my mood. I am not wanting to eat as much and I have lost like 3 pounds already. I went from 203 lbs. to 200 lbs. and it makes you energized and wanting to do something all day. Honestly I’ve never felt better about myself than I do now. I’m hoping I don’t have any reactions to the Biphederene but you never know because it really doesn’t help that they won’t give out all the ingredients in this product. I wish the best for anyone who is taking it. I am 18 going on 19 and I take the pills once daily and eat portion sized meals 3 times a day and I also try to exercise more than an hour a day. It seems to be helping me so I would probably recommend it.

  • domino 88 asia

    whoah this blog is great i like studying your articles. Keep up the great paintings! You recognize, lots of individuals are hunting around for this information, you can aid them greatly.

  • Can someone provide more feedback?
    Deana Payne

    Hello im Deana Payne i would love to here from some one thats tryed this becouse im a 47 year old femaleand im 5ft/4in tall and kind of top heavy but between us i weight 178lb thats a lot im taking thynoid meds and more then a few outhers dut i still need some thing to help me get fid of about 35-40lbs around ther

    • Brandy Bueno

      Deana, I am 40 yes old & we are the same height & weight. I just keep getting bigger! I have no energy therefore I don’t exercise. My question for you is have you tried the Biphedadrene yet? I don’t want to waste more money on more lies. Please let me know what you think

      Thx
      Brandy

    • Anonymous

      Not a good idea on thyroid meds. U have to be really careful with strong diet pills and thyroid. My opinion, not worth the risk for you. Try to find something more natural.

  • How to use it?
    virginia weaver (Verified User)

    I got my box of biphedadren on may 24th 2013 and have been taking it like it said but I would like to know how long it will be before I start to see weight loss.. I did not get any book telling me what to expect from taking these diet pill’s.

    • jaytee404

      I took this for I think two months with moderate exercise and diet. I didn’t take it seriously but by the end of two months I had lost alot of weight. I started to notice my jeans very loose they weren’t holding onto my body anymore, everybody was in shock and when I got on the scale, I was weighing 124lbs from my usual 143lbs. Love it

  •  Loved the product.
    Evy Vaudrin (Verified User)

    This is my first day trying BiphedAdrene. Wth all the bad reviews I’ve seen from a few websites, it almost completely discouraged me from getting this product, but i have to say that i’m loving it so far, after taking the first dose yesterday morning it started to work in 15 mins! i felt the rush of energy that made me want to get out of my pj’s and exercise, instead of lounge around sitting in front of the tv watching re-runs of gossip girl. I’m 5’6 and 100lbs over weight and i’ve been wanting to lose it but had no energy and always felt down, but i feel great! which contributes to me want to be more active and is definately a plus. My appetite has decreased and im not constantly thinking about food, i did noticed that i’ve been super thirsty and have been drinking more water which i normally don’t do, so that’s another plus. i started this with my sis-in-law and she feels the same, that this is working! the only downfall about it is that its very costly, but i’m glad i can purchase it through Amazon and i can take advantage of the prime thing and get the shipping for free and that they are super quick too! so heres’s my 1 vs 1000 great review!! so i’d say give it a try and if doesn’t work for you.. then move on!

    • lorraine

      drink more water

  •  Loved the product.
    Alyssa (Verified User)

    I’ve been on it 3 days. No negative side effects. Lost 4 lbs in that amount of time and I’m a lot more energized and seemed to put me in a more positive mood. I take it twice a day and I have zero problem sleeping. I would recommend it so far.