Updated: 12/06/2017

Calotren has been the talk of the town recently, but not the kind of talk that would get you pumped to run out and buy the product. When our team first got into the ingredients and side effects we realized a lot of chatter on lack of results. To get to the bottom of things, we dove into the scientific research. Is there even anything out there supporting it? Finally, we tossed the information we found into a blender to serve you up a truth smoothie on this weight-loss supplement.

Calotren Readers: Click here to find out why we're giving away samples of our product, Burn HD.

What is Calotren?

First of all, Calotren is a supplement that uses collagen protein to increase energy, offer joint support and help shed pounds. The ingredients are:

  • Collagen Hydrolate
  • ProHydrolase
  • Vitamins

Of course, healthy eating is encouraged for increased results. The issue that stood out to us the most was the lack of scientific evidence that this formula causes weight loss at all. This might be a good indication why so many users aren’t happy with the product. In addition to this, the price of the supplement is out-of-this-world, and not in a good way.

Top of the World Distributors released Calotren in 2010. The company was founded in 1997, but with so many negative customer reviews and without any actual scientific evidence to support the formula, it’s hard to get excited.

No Real Clinical Evidence – “A Problem?”

Our first concern with Calotren ingredients is a lack of clinical support.“There is no actual evidence presented on the formula regarding weight-loss or fat reduction,” said our Research Editor. “While this supplement may help with protein absorption, this could be why some customers didn’t see results.” [2]

One user said, “I tried Calotren for a month and received no results. Worked out, cut back food in-take and didn’t eat after 7pm every night. Didn’t feel any different health wise either.”

Another stated, “Well it don’t work for my wife, and she’s not very happy about this product. I think she gained weight instead of losing.”

Calotren Customer Testimonials

Negative Customer Reviews – “Not Good”

While we were able to find a few customer testimonials posted online for Calotren, there are also negative user reviews. One dieter said, “If you are at all sensitive to taking pills, don’t do this! I followed the instructions, waited the 3 hours after eating before taking it, and then barely slept all night. It says “no stimulants” but something kept me awake and feeling sick all night.” [3]

“I tried Calotren for three months. Did not loose any weight. It was a waste of my money. Would not recommend it to anyone,” claims a buyer

Our research has proven if a specific part of a weight-loss product or diet formula is especially problematic (a painful/difficult exercise routine, no clinical research, too many customer complaints) the likelihood of real success, for the long run, is slim. If Calotren does in fact fail to produce results and leads to bad reactions, as reported by some customers, this could be a major issue.

The Science of Calotren – “Nothing Available?”

There is no scientific research presented for Calotren. For us at DietSpotlight, we need to see documented clinical support for the supplement and its ingredients. While this product is claimed to produce great results, there is simply no real evidence to support fat loss or weight management. [4]

Also: read our Burn HD Weight-Loss Kit review »Calotren Ingredients

The Bottom Line – Does Calotren Work?

Let’s take a closer look at our results, shall we? Calotren is an interesting weight management supplement and it does contain some intriguing ingredients. However, we can’t recommend this diet product because there is no published clinical data to support this formula. Furthermore, Calotren is quite pricey at $69.95 per bottle. Not to mention, there are no customer testimonials about the product. [5]

For dieters who need to slim down and shed pounds more quickly, we suggest you to go with a weight-loss supplement that is both affordable and backed by real scientific studies and supportive customer reviews.

Among the best products we’ve seen this year is our product called Dietspotlight Burn. This proprietary blend of four ingredients is clinically-tested with results often found in studies published in The American Journal of Clinical Nutrition.

Plus, we’re so confident that you’ll love our supplement, that we’re offering a Special Trial Offer, which is a good sign.

Learn More About Burn HD »
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What are the side effects of Calotren?

Calo trimmed from Calotren, potential side effects include stomach discomfort, cramps, gassiness, nausea and diarrhea.

What are the ingredients in Calotren?

Calotren ingredients are filtered water, collagen hydrolysate, aloe vera, vegetable glycerin, natural and artificial raspberry flavor, potassium sorbate, citric acid and sodium benzoate.

How do I know if Calotren is right for me?

Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients.

Click here to get your sample of our powerful fat burner today.

Does Calotren work?

The company provides information about the benefits of protein and digestive enzymes. We found that there’s no scientific research connecting Calotren to weight-loss or improved health and wellness.

How much does Calotren cost?

Calotren costs $69.95 for the liquid or capsules. If you purchase two bottles, you’ll pay$104.93 and $189 for three.

How should I take Calotren?

You should take Calotren a minimum of three hours prior to sleep. You take one teaspoon or four capsules with water. The company recommends taking the supplement for 90 days.

What can I drink before taking Calotren?

You can drink water before taking Calotren.

How much protein is in a serving of Calotren?

Each serving contains 3g of protein.

Do I need to diet on Calotren?

No, you don’t need to diet on Calotren, but the company recommends eating healthy to maximize results.

Why do I need to take Calotren at night?

You take Calotren at night because the majority of food consumed is digested.

What is the source of protein in Calotren?

The source of protein comes from beef and marine foods.

Is there a guarantee with Calotren?

Calotren offers a 45-day money-back guarantee. You can return purchased items for a 100% refund. This policy doesn’t apply to items received a free gifts. You are charged a $10 restocking fee.

You may want to check out Dietspotlight Burn, a weight loss supplement that contains clinically researched ingredients.

Calotren Ingredients

Calotren is a weight-loss supplement from Top of the World Distributors. According to the company, customers have reported decreased joint pain, improved sleep and increased energy. There is a liquid and a capsule with the program. The ingredient lists don't show anything with strong clinical support, in terms of weight-loss.

Calotren Ingredients and Supplement Facts

Serving Size: 1 TBSP or 4 Capsules
Serving Per Container: 30
Amount per Serving% DV
Calotren Advanced Capsules**
- Collagen Hydrolysate**
- ProHydrolase**
- Aloe Vera Leaf Extract**
Calotren Liquid**
- Collagen Hydrolysate**
- Aloe Vera**

Other Ingredients: May include: filtered water, gelatin, vegetable magensium stearate, vegetable glycerin, natural and artificial raspberry flavor, potassium sorbate, citric acid, sodium benzoate

We examined the Calotren ingredients in order to give you the facts you need.

Collagen Hydrolysate

Collagen hydrolysate is an amino acid, in which high amounts of glycine, lysine, and proline, which are not often found in other protein supplements. [1]

What Is It Supposed To Do?

Collagen hydrolysate is often used as an extra nutritional aspect in dietary supplements.

Clinical Research

According to a study published in Current Medical Research and Opinion, “e results of this study have implications for the use of collagen hydrolysate to support joint health and possibly reduce the risk of joint deterioration in a high-risk group. Despite the study’s size and limitations, the results suggest that athletes consuming collagen hydrolysate can reduce parameters (such as pain) that have a negative impact on athletic performance.” However, nothing was said connecting it to weight-loss.

Aloe Vera

Aloe vera is a plant composed primarily of water. However, it contains many minerals that can be beneficial to the body.

What Is It Supposed To Do?

Aloe vera has many benefits to the body, including aiding in digestion, fighting disease, and helping the immune system.

Clinical Research

In an article published in Herbal Medicine: Biomolecular and Clinical Aspects: 2nd Edition, “Despite its long history of use, there remains a lack of consistent scientific evidence to support many of the therapeutic claims for Aloe vera.”

Filtered Water

Filtered water is just regular water that has been pushed through a filter, where it becomes cleaner.

What Is It Supposed To Do?

Though water is generally essential for any life, filtered water can prove to have some benefits, including activated carbon, aeration, cation exchange, distillation, reverse osmosis, and UV disinfection.

Clinical Research

In a study published in Nutrition Reviews, “Both studies reported more rapid weight loss among pre-meal water drinkers.” This does not count for supplement because this study was conducted with the consumption of water before meals.

Vegetable Glycerin

Vegetable glycerin is a clear liquid that has a sweet taste. It is used commercially for cosmetics and food.

What Is It Supposed To Do?

Vegetable glycerin is used for solvents, sweeteners, antifreeze, soaps, cosmetics, and more.

Clinical Research

In a study published in Metabolism: Clinical and Experimental, researchers noted, “Glycerol [another name for vegetable glycerin] did not differ from an equicaloric dose of glucose in its effect on hunger ratings, diet compliance or overall weight loss. We conclude that oral glycerol is not a useful adjunct to weight reduction programs.” [2]

Scientific research is critical to the review process, so one that’s caught our attention is one called Dietspotlight Burn. It contains clinically-tested ingredients and has been shown to work. Click above to learn more.

Calotren Scientific Abstracts

Collagen Hydrolysate

Following a 24-week-long trial of athletes that were given a collagen hydrolysate supplement findings conclude that collagen hydrolysate could be used to encourage joint health and probably decrease the chance of weakening joints in a high-risk group. Results recommend that athletes that ingest collagen hydrolysate could reduce negative limitations on performance. [1]

While not scientifically proven, it has been suggested that collagen weight loss products can enhance lean muscle mass and encourage fat burning. It was noted that a hydrolyzed collagen product would demonstrate effective weight reduction in 50 overweight people. The same study that was conducted by Essentially Yours Industries Corp. Office of Product research concluded that when consumed daily in one tablespoon increments a collagen hydrolysate product generated weight loss of an average of 10 pounds in a three-month span. [2]


When used as a component in protein supplements or meal substitutes, ProHydrolase that was created to construct muscle mass and speed up muscle healing. Through clinical studies, it has been found to process protein in a bio-useable structure while gaining the accessibility of vital amino acids for building muscle and better muscle recovery. It was found to be successful with whey, casein, soy, egg, and pea and hemp proteins. It has been shown through two different studies ProHydrolase’s ability to boost amino acids in the blood by 20 percent, aiding in muscle mass building and enhancing the recovery of muscles when it is paired with a protein supplement.

Aloe Vera Leaf Extract

Aloe vera, a common healing plant that is well known for taking care of skin wounds, has been around and used for thousands of years. Aside from being good for the skin, there are many other health benefits of aloe vera. It possesses antioxidant and antibacterial properties. It’s most common use is as a topical medicine for lesions and burns. Studies show that also vera may assist in decreasing the time it takes a wound to heal by nine days compared to other medications. Studies found that using aloe vera as a mouth rinse was as successful as the common ingredient in mouthwash chlorhexidine at eliminating plaque bacteria and yeast in the mouth. Aloe vera has been strongly studied and proven to speed up the curing of mouth ulcers. Another study showed that while aloe vera sped up mouth ulcer recovery, it also decreased the pain that comes with them.

Aloe vera has been said to help with constipation when using the latex form; the main compound aloin is what contains the laxative impact. Since 2002, aloe vera latex has not been accessible as an over the counter drug due to safety alarms linked to consistent use. It has not been found that aloe vera is successful against digestive illnesses like irritable bowel syndrome (IBS) or inflammatory bowel syndrome (IBD). Some initial findings show that aloe vera gel can slow down the skin’s aging process. It was found through a 90-day study that aloe vera gel applied to the skin increases collagen construction and enhanced the elasticity of the skin. Aloe has been said to lower the blood sugar levels in people with diabetes. Hopeful results were found from ingesting aloe vera extract through many studies of type 2 diabetics, although the quality of these studies is weak. [3]


Previous Calotren Review (Updated February 6, 2014):

What You Should Know about Calotren

The weight loss product Calotren is a protein supplement manufactured and distributed by Top of the World Distributors. Calotren seems to claim to be a metabolic supplement that is suitable for both overweight users and users looking to improve their metabolic health. Interestingly, Calotren seems to come in both liquid and capsule form. A 30-day supply of the supplement retails from the manufacturer for approximately $65.00, making it a moderately expensive regimen to maintain. Instructions for Calotren use indicate that a full course of the supplement is intended to last 90 days, yielding weight loss and a more toned physique. If this is out of your budget, you might want to consider Addrena as it's a dietary supplement used to boost energy levels and enhance metal focus while encouraging fat loss. Both the liquid and capsule forms of Calotren are protein-based formulations. The product contains no ephedra or caffeine, both of which have been found to over-stimulate the metabolism and potentially cause rapid heart-rate and "jitters." The official product website goes out of its way to point out that Calotren does not "stimulate, starve or trick" your body. While that does sound appealing, the further product claims are a bit ambiguous, implying that Calotren acts as a "support" for the body's natural fat burning cycle, while also boosting stamina in non-overweight users. This ambiguity, both as to the product's applications and its active ingredients, strikes us as a bit off. The mysterious Calotren protein also claims to benefit wrinkled skin.

List of Calotren Ingredients

The active ingredients of liquid Calotren are: Oxygenated water, Collagen Hydrolysate (Bovine Source), Aloe Vera, Glycerin, Potassium Sorbate, Natural Raspberry Flavoring, Methyl Paraben. The active ingredients in capsule Calotren are: Collagen Hydrolysate (Bovine or Marine Source - your choice), Aloe Vera, Vegetable Glycerin. Inactive ingredients in both forms of the product: Gelatin, Magnesium Stearate, Stearic Acid and Microcrystalline Cellulose.

Product Features

Calotren is intended to be taken once per day. Take either a single tablespoon or four pills of Calotren in the evening before going to sleep. For most effective results, do not eat anything three hours prior to taking the product and, if taking the pills, use only a glass of water to wash them down. This is so that your body can begin using the Calotren while you sleep. Top of the World Distributors also claim that taking Calotren in the morning or before exercising will give users increased energy. Calotren is laced with Aloe Vera, which has been known to transform fat and carbohydrates into energy, rather than storing them in the body.

Advantages of Calotren

  • Product is available from manufacturer online.
  • Product does not contain caffeine or ephedrine.

Disadvantages of Calotren

  • Product claims are very broad, making it sound like an all-around "miracle" supplement. We'd prefer a product that focuses specifically on weight loss.
  • Reading the ingredient list, we see no proprietary ingredients that separate this product from others.
  • No free sample.


While we certainly appreciate that Calotren does not contain caffeine or other potentially harmful stimulants, like Animal Pak, but we're not really impressed by what it does contain. We are also weary of any product that claims to help with weight loss, boost energy and clear up wrinkles, all in one package. With so many proprietary products on the market for the same price, we'd hold out for something that can offer more sophisticated lab research and an approach that is specifically targeted towards weight loss.
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.

19 Calotren Reviews

  •   Calotren works differently on different people
    Michele (Verified User)

    I’m going to go out on a limb and say that Calotren – just like any other weight loss program – works differently on different people. I’m just sayin’ – I mean anyone with any sense knows that not everything works on everybody the same way. Thanks!

  •  Hated the product.
    Linda C (Verified User)

    I have taken this diligently for just over a year now. Exactly like I`m supposed to. Even did 3 rounds of Probiotics purchased thru same company as suggested. To date, I have not lost 1 single pound. Nor any inches. Nothing whatsoever. Very, very disappointing. I tried so seriously. Hoping.

    • Victoria (Editor)

      Hi Linda! We’re sorry that you didn’t achieve the results you wanted with Calotren. Have you tried looking into other metabolism boosters and fat burners? You should check out Dietspotlight Burn!

      • Cathy Zimmerman

        Ms. Linda,
        You are not alone, I run 4-5 times a week and take the pills at the same time every night, and have not lost even a pound. I have fought with my weight my entire life. I was the only 5 year kid on a diet. Been in the Army 24 years and weight is such a critical topic.

  •  Patience is definitely the key here.
    June (Verified User)

    Calotren works but it does take a while. You must be diligent in taking each night. It was not until the 13th week that I noticed my clothes were loose when usually tight and at that moment became a believer in the product and continue to use. Patience is definitely the key here. Thanks Calotren!

  •  Lost a Little Weight
    Cindy N (Verified User)

    My husband and I both started Calotren right after Thanksgiving 2014…not yet reached 60 days. He has lost a little weight. I have not really seen any weight loss but have been able to move down from size 18-20 to my size 16 pants already. Can’t wait to see how things continue if things normally take at least 90 days for any real results as the instructions say. We have not changed anything at all about our routine or meals. Oh we are both 56 years old and remaining optimistic.

  • Lisa Dantin

    I started Calotren in october, I have taken it nightly for 109 days. I started losing inches after about the second bottle I was on. I am now on bottle 4 and have lost one pant size and 10.2 lbs. I do believe you start to see the best results after your 90 days. I had been having trouble with both of my legs hurting at night after doing a complete split while mopping my closet in Auguest 2012…

    I would turn from side to side all night long with shooting, stabbing pin-like pain in both legs…I can honestly say the pain is now gone, and I sleep so much better now. I am on NO diet, and eat whatever I want…please give it at least 90 days to see results…it is awesome, and I will continue to take it!

  •  Never lost a pound but it helped me to sleep through hot flashes better.
    Sarah McDonald (Verified User)

    Never lost a pound, but after ripping my rotator cuff in my shoulder, it worked wonders at healing it. Also, as an older woman approaching menopause, it helped me to sleep through hot flashes better.

    • Montana (Editor)

      Hi Sarah! If you’re looking for a way to lose weight, you may want to check out Dietspotlight Burn!

  •  Two months passed and haven't lost a pound
    MS (Verified User)

    Two months and haven’t lost a pound and have followed what they said, 4 pills with water at bedtime and no food 3 to 4 hours before.

  •  This product works. I love it!
    Shauna (Verified User)

    I have been taking Calotren for over a year now. The first month of use I didn’t notice any change in weight loss, the second month, I dropped an entire pant size. I’m not a heavy person, size 10 and I dropped to a good size 8 (my clothes fit really good, not to tight and not to baggy). I had no change in my diet. Nor did I drink water with taking the pill and still had success.

  •  Hated the product
    Dawn (Verified User)

    I’ve tried Calotren for a month and although I eat a healthy, low fat calorie diet averaging between 800 and 1000 calories a day, I haven’t lost any weight at all. I feel it was a waste of my money.

    • Anonymous

      unless you are a ” little person ” you should be eating at least 1200 caleries a day so your body doesn’t go into famine mode and store everything.

  • Jackie

    I have been taking Calatren now for 5 month and no weight loss……

  •  Hated the product.
    Kelly (Verified User)

    I tried Calotren for three months. Did not loose any weight. It was a waste ofmy money. Would not recomend it to anyone.

  • Debra Abshier

    I take it a 10pm right before going to bed and then I can not go to sleep until 3am. I have tried everything to lose weight and thought since Bama Brown lost 100lbs it must be the best product for me. I tried to take this for 2 weeks with no weight loss and no sleep. Dont like it. im going to stop taking this product.

    • Julie Mortenson

      My husband bought 6 bottles for my daughter and myself because Bob Cole at KVET had lost weight on it since I think December. But the thing you don’t hear in the ads is that (it tells you this in the book that comes with it) you’re supposed to give up starches while on it. Well, heck I know I can lose weight if I completely give that up. But they made it sound like you didn’t have to do anything special to lose weight while on this. BTW my daughter and I have not lost hardly anything yet.

    • Sara Tanner

      I have never slept better with this product! And it has aided me in losing 20 lbs in the last two months. Other than watching my fat intake and taking Lipozene, I am not actually dieting. I know three people personally that did nothing but take this product and still lost approx. 5-6 lbs per week.

      • Renee

        I sleep great when I take Calotren. I have more energy and therefore I am more active and that might be why I lose weight with it but either way I totally recommend anyone give it a try.