This review is what happened after I obsessed for weeks over Contrave. We decided to take an in-depth look at the prescription diet pill, side effects, ease of acquiring and clinical research. Additionally, we examined hundreds of dieter comments and testimonials. Then, we summarized and refined to give you the info you need.
What is Contrave?
To start, Contrave is a prescription weight-loss medication for individuals who have a BMI  of 30 or greater or a BMI of 27 or greater with medical condition related to their weight . The ingredients are bupropion hydrochloride and naltrexone hydrochloride. You’ll take one tablet each morning for the first week. The second week you’ll use one in the morning and another in the evening. By the third week, it’s two tablets, twice per day. Dosage depends on the prescription received from your physician. 
Contrave  has been available since 2014 and was approved by the FDA. The medicine, which affects the appetite and reward center of the brain, is made by Orexigen Therapeutics. We like that we found some positive dieter comments and that a healthy lifestyle is encouraged, but read on…
Contrave High Cost – “Too Expensive?”
The first concern relating to Contrave ingredients is the high price tag. “The cost of this medication varies, depending on your insurance coverage,” said our Research Editor. “Some dieters have reported spending upwards of $200 for a 30-day supply.” 
One dieter stated, “Without insurance, my scrip would be $299 per month.”
According to another user, “It was $142 without insurance.” 
We found some Contrave reviews that didn’t mention the cost.
“Yes, it’s pricey, but the results I’ve seen are worth every penny,” said a consumer.
Contrave Side Effects – “Not Good!”
There is a list of Contrave side effects  available on the official website. One user commented, “I started two days ago and have felt very dizzy and throwing up to the point that I’m in tears.”
“I have started 10 days ago and I’m still fighting side effects (nausea, diarrhea, dizziness mainly),” said another.
According to some Contrave reviews, side effects are rare.
“I did have some of the side effects initially. I had dry mouth, was dizzy, hot flashes and had headaches. They all went away in the first two weeks,” stated a user.
“I have been on this Medicine for exactly 7 days and I haven’t had any side effects everyone talks about,” reported another. 
According to our research, if there is a small issue or problem with a weight-loss product, like side effects, that can negatively affect result and long-term dedication to a program. With Contrave, the list of potential risks are openly published on the official website. As is the case with all prescription medications, the risks need to be weighed against the rewards.
The Science – “Clinically-Proven?”
There have been clinical studies conducted with the two key ingredients used in Contrave. They have been proven effective in the medical treatment of depression , smoking cessation , weight-loss and other conditions. However, there are a couple roadblocks. You have to have a prescription and there are strict guidelines doctor’s have to follow before prescribing. Taking everything into consideration, we believe Contrave could be beneficial for some patients who are overweight or obese. Regular medical visits will be necessary during treatment.
The Bottom Line – Does Contrave Work?
Well now, what about this prescription medication for weight-loss? We like that Contrave is regulated by the FDA and that we found some favorable customer comments. We are concerned about customer comments relating to the high cost and negative side effects.
If you’re looking to slim down, we always suggest a supplement made with clinically tested ingredients shown to have the effect you’re looking for. It’s also nice if you don’t need a prescription or a loan from the bank.
Among the best products we’ve seen this year is one called Leptigen. This supplement contains four clinically-tested ingredients, which have been shown to help accelerate fat loss and increase metabolism. Also, there’s no talk of harmful side effects and dieter reviews around the web show people are seeing solid results.
Plus, the makers of Leptigen are so confident in their supplement, that they’re offering a Special Trial Offer.
Previous Contrave Review (Updated August 12, 2014):
Contrave: What You Should Know
2/2/2011 UPDATE: Today, the FDA rejected Orexigen Therapeutics Inc.'s Contrave pill, citing fears that the pill may increase heart risk. The FDA has not approved a new weight loss medication in ten years. The agency says it will evaluate Contrave again after Orexigen undertakes a costly new study examining possible links to heart risk. A spokesman for Contrave said that the company is evaluating next steps and deciding whether they will go through with the expensive study. Sorry, bad news for everyone who was looking to try this promising new drug.
12/9/2010 UPDATE: Today, the Endocrine and Metabolic Drugs Advisory Committee, a division of the FDA, has voted to recommend Contrave as a weight loss aid. However, the FDA still has to give the drug final approval before it can be distributed by physicians. The FDA takes sub-panel decisions such as this into consideration before approving any pharmaceutical drug. Like, the FDA will decide on approving Contrave for weight loss in January, 2011. However, the panel also recommends additional cardiovascular studies of patients prior to beginning sales based on case study findings, indicating that this product still may not be suitable for those with heart conditions. We will continue to update our review as more information becomes available.
Contrave is still in the testing stages, but it seems to offer great promise as a medication that will actually reduce the risk factors associated with obesity. Currently, this drug is in its third stage of clinical trials to assess the "safety, tolerability and efficacy", according to the company website. The company that is responsible for Contrave is Orexigen Therapeuticals, a biopharmaceutical company that is focused on creating drugs that treat central nervous system disorders, including obesity. Current studies are showing that Contrave can effectively reduce metabolic syndrome in many patients. Metabolic syndrome is a combination of risk factors that may increase the incidence of obesity, which can also increase the risk of heart disease and diabetes. This medication takes a whole new approach to weight loss, by focusing on neurological causes of obesity rather than suppressing appetite or altering metabolic function. Opposite to the focusing on the mind, Phentermine suppresses the appetite, tricking the mind that the body isn't hungry.
List of Ingredients in Contrave
The two main ingredients that are being studied in the Contrave formula include Naltrexone and Bupropion. On the other hand an alternate product, Jadera Diet Pills concentrates on a bitter orange, cassia seed and mulberry leaf said to boost the metabolism and burn fat. Naltrexone has been used in the United States to treat opioid addiction since 1984, and in 1995 it began to be used to treat alcoholism as well. This drug inhibits the reinforcement of addictive substances by blocking opioid receptors to the brain, according to the Orexigen website. Naltrexone has also been shown to alter the taste of foods in numerous clinical studies. Aside from Contrave, IdealShape is a weight-loss system consisting of meal replacement shakes, snacks and supplements, and when paired with exercise there’s a good chance for weight-loss.
Bupropion has been used to treat depression since 1985, and in 1997 trials were begun that experimented with the use of Bupropion as an aid to help quit smoking. This drug appears to be effective at suppressing appetite and increasing energy levels, and is the most prescribed antidepressant in the United States at the time of this review. One side effect that has been noted with Bupropion is weight loss; an attractive side effect for many indeed.
Since this medication is still in the clinical trial stage, there are few product features to report. It is suspected that this medication will only be available by prescription, since it contains potent ingredients with potentially dangerous side effects. There is no pricing or customer testimonials at this time; however, ample clinical data is provided on the Orexigen website, and this info is comprehensive and professionally displayed. Aside from Contrave, some clinical research found with BiphedAdrene show rapid weight loss results from increased energy endurance.
Advantages of Contrave
- The ingredients in Contrave may be effective in suppressing appetite and promoting weight loss.
- Many clinical studies have been done on this product and are continuing at this time.
- The company website contains ample information on the developmental progress of this product.
Disadvantages of Contrave
- This product is not yet available to the general public at the time of this review.
- The ingredients in Contrave may have potentially serious side effects for some. (See Contrave Side Effects).
- May interact badly with other prescription medications.
Conclusion About Contrave
Contrave is worth keeping an eye out for, since the initial clinical studies have been promising and plenty of research is being conducted on the product. However, Contrave will not be the right choice for everyone, due to the possible side effects and medication interactions that may occur. Also, it definitely appears that Contrave will be prescription only, and will most likely be used to treat clinical obesity. It is important to talk to your doctor about whether Contrave would be a good choice for you.
Contrave Questions & Answers:
We picked apart hundreds of user comments about Contrave and condensed into this helpful FAQ.
What are the side effects of Contrave?
Some Contrave side effects may include diarrhea, dry mouth, sleeplessness, dizziness, vomiting, headache, constipation and nausea.
What are the ingredients in Contrave?
Contrave are ingredients bupropion hcl, naltrexone hcl, microcrystalline cellulose, hydroxypropyl cellulose, lactose anhydrous, L-cysteine hydrochloride, crospovidone, magnesium stearate, hypromellose, edetate disodium, lactose monohydrate, colloidal silicon dioxide, opadry II blue and fd&c blue #2 and aluminum lake.
Does Contrave work?
There is scientific research into the effectiveness of Contrave as the medication has been FDA-approved, but there are also clinically proven side effects.
How much does Contrave cost?
Contrave costs about $300. The price could change after insurance is factored into the equation.
How should I take Contrave?
You should take one Contrave capsule in the morning the first week, one pill in the morning and another in the evening the second week. On the third week, you will consume two in the morning and one in the evening. The fourth week and beyond, you will take two in the morning and two in the evening. The company recommends not crushing, chewing or cutting the product, as well as not taking the pill with high-fat meals.
Can I take Contrave if I have a health condition?
Women who are pregnant or nursing, those with health conditions of any kind, people under 18 years of age and anyone taking prescription medications should consult with a healthcare professional prior to using a weight-loss medication, including Contrave.
What do users like about Contrave?
What do users NOT like about Contrave?
We found that some users didn’t like the high price tag of Contrave and the side effects.
How do I contact the Contrave customer service department?
You can contact the Contrave customer service department by mailing correspondence to Takeda Pharmaceuticals One Takeda Pkwy. Deerfield, IL 60015, calling a representative at 1-877-825-3327 or by using the customer feedback form on the official website.
Who uses Contrave?
Individuals that are considered overweight or obese use Contrave. Your BMI has to be more than 27.
Can I stop Contrave on my own?
No, you can’t stop Contrave on your own. You will need to contact your healthcare provider prior to stopping this medication because of the potential for withdraw symptoms.
What should I tell my healthcare provider before taking Contrave?
You should tell your healthcare provider if you have a medical condition, if you are taking prescription medication or if you are pregnant or nursing.
What should I avoid while taking Contrave?
You should avoid using alcohol on Contrave.
Does Contrave come with a guarantee?
There’s no mention of a guarantee with Contrave.
Do you know of any special deals or discounts on Contrave?
There are special deals or discounts on Contrave, if you sign up for the savings card. However, our readers have been going crazy over the past few months taking advantage of Leptigen’s Sample Trial Offer. Click above to learn about the sample offer.
Contrave Scientific Abstracts:
Regarding both conduct issues as well as hyperactivity, there was a significant effect visible in the Conners 10 and 39-item teacher’s checklist as early as the third day. On day 28, there were significant visible effects on both conduct issues as well as restless-impulsive behavior (93-item parent’s questionnaire). The results were found to be smaller regarding the parent ratings compared to teacher ratings. There had been substantial effects with treatment on both Continuous Performance Test as well as memory retrieval test. The magnitude of the consequences of bupropion and placebo were smaller within parent and teacher ratings than in standard drugs used in the treatment of ADDH. Bupropion had been found to be well tolerated in children, for the most part. Bupropion could be a helpful addition to treatments for ADDH, with an urge for further comparative trials using methylphenidate to solidify bupropion’s clinical merit. 
Bupropion blocks the re-uptake of dopamine and norepinephrine neurotransmission minus significant direct activities on serotonin neurotransmission. Bupropion has proven its effects as an antidepressant with comparable efficacy to other antidepressants. It is considered to be well tolerated for both short and long-term treatments with a headache, nausea, dry mouth, constipation, dizziness, and insomnia being the most common negative reactions. Some allergic reactions and seizures were reported, but rare. Bupropion has shown to have the lowest reports of sexual dysfunction, somnolence and weight gain in comparison to newer antidepressants on the market in the US. Bupropion is and will be a crucial part of major depressive disorder treatment in adults, among other related disorders. 
Any clinical data which backs up its use is extremely preliminary, suggesting further research before treatment can be recommended on a broad scale. Analysis from a plethora of basic and clinical research indicates that LDN has promising potential for being a treatment for chronic pain involving inflammatory activities. Dosing and other relevant parameters still require refinement. LDN could find itself emerging as the first glial cell modulators used in the treatment of chronic conditions, with the development of more certain medications in the future. 
- 1. Bupropion hydrochloride in attention deficit disorder with hyperactivity (1996). Journal of the American Academy of Child and Adolescent Psychiatry. November 9, 2016.
- 2. 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL (2005). Primary Care Companion to the Journal of Clinical Psychiatry. November 9, 2016.
- 3. The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain (2014). Clinical Rheumatology. November 9, 2016.
Contrave Side Effects:
As us true with all diet supplements, there is a chance of adverse side effects. In the case of Contrave, users have reported several troubling effects that should be considered prior to usage.
Nausea is a sensation of uneasiness that is triggered by the brain and centered in the stomach or abdomen Nausea is not itself a an illness but is a sensation that is felt. It occurs when the brain sends a message to the abdominal region that something may be awry. Nausea is nearly always linked to vomiting. 
What causes nausea?
Nausea can be caused by both slight and serious conditions. Nausea can occur due to motion sickness or from stress or anxiety. It can be brought about by medications, supplements or alcohol. It can also be a result of a problem within the brain or the circulatory system.
Every person has diarrhea from time to time. Diarrhea is watery, loose and frequent bowel movements. Diarrhea is often associated with nausea and vomiting. Diarrhea is when the intestines empty themselves in a defensive manner over concern for its contents. Excessive diarrhea leads to dehydration and can become life-threatening. 
What causes diarrhea?
Diarrhea can be caused by food poisoning, alcohol, medications, supplements, food allergies and lactose intolerance. Stress and anxiety can also be contributors. More serious causes include ulcers, cancer, obstructed bowel and IBS.
Dizziness is the sensation that you cannot steady yourself. It’s the feeling that either you or your surroundings are spinning or in motion. Dizziness comes from the brain and is a message that all is not right. The brain is crying foul and telling the body to shut down immediately. Typically, dizziness occurs in conjunction with nausea and vomiting.
What causes dizziness?
There can be many causes of dizziness including head injuries, brain tumors, or other debilitating diseases. Less severe causes can be the flu, food poisoning, alcohol, or adverse reactions to medications or supplements.
As always, consult your physician before taking any weight-loss product. In the case of Contrave, there are many side-effects that should be considered.
In the weight-loss market there are some prescription medications that require a deeper look, like Contrave. We took this opportunity to pore through Contrave side effects via ingredients and clinical research. We also found hundreds of comments and reviews to take into consideration. Then, we condensed and refined to give you the bottom line.
What You Need to Know
First off, Contrave is a prescription weight-loss medication comprised of naltrexone and bupropion. You start with one tablet in the morning and eventually move to two, twice a day. The formula is supposed to help dieters lose more weight. The pills are relatively small as is the bottle so you can take it with you during the day.
The medication, approved by the FDA in September 2014, is proven to help dieters lose weight, a good thing. You need a prescription to buy it at a pharmacy or online. We like that some users have seen positive results, but read on…
“Holy Warning Label!”
The first issue we have with Contrave side effects is the warning label. Common issues include nausea, dizziness, constipation, trouble sleeping, dry mouth, headache, diarrhea and vomiting. “When you choose a prescription medication for weight-loss there is a trade off,” says our Research Editor. “You have to work closely with your physician to decide whether or not the pros outweigh the cons.”
“Feeling tired, some nausea and dizziness. hope this will go away soon,” says a user.
“I have been on Contrave for over two months, I’m sick everyday. I can’t eat anything,” explains a dieter.
Some reported side effects were severe, “Second day made me seriously ill. Nauseous,twilight zone, dizzy and suicidal thoughts. NEVER will I take this again!!!!”
Contraindications -“We’ll Be Here a While!”
One of the scariest parts of Contrave side effects is that there are so many potential interactions and contraindications. When working through the positives and negatives of the medication you have to take these into consideration.
According to the Contrave prescribing information the medication “is contraindicated in people with hypertension…seizure disorder…alcohol or opiate addiction.” There’s also concern in patients with mental illness, suicidal thoughts, diabetes, high blood pressure, coronary issues of any kind and glaucoma.
Specific medications that interact with Contrave are lorcaserin, bupropion, phentermine, tramadol, trazodone and lisdexamfetamine. It is important to check with your physician if you are on anything before starting this treatment.
We’ve found through research, a connection between seemingly small issues, like contraindications, and a lesser chance of long-term success. If Contrave side effects and negative interactions make taking the pill worrisome for the dieter, it may not be the best option.
The FDA makes sure medications are tested on animals and humans before being approved for sale. Contrave side effects are also clinically proven. Though this drug is relatively new on the market, bupropion (one ingredient in the formula) has been around since 1989 so the potential reactions are well documented.
The Bottom Line
If you’re ready to shed those extra pounds, we recommend trying a product that offers clinically proven results without the side effects.
Among the best supplements we’ve encountered in 2016 is Leptigen. The formula is made up of a four-ingredient proprietary blend that’s clinically proven to help spark metabolism and accelerate fat loss. There are no reports of negative side effects, but we found numerous dieters speaking of excellent results.
The company behind Leptigen is confident enough in the formula to be offering a Special Trial Offer, which is impressive.
Contrave is a prescription weight-loss medication that contains an anti-depressant. It is not unheardof for these drugs to be used for a variety of reasons like weight-loss and smoking cessation. You cannot purchase this formula in stores or online without a prescription.
Contrave Ingredients and Supplement Facts
Serving Per Container: Varies
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Other Ingredients: None
We dug deep into the Contrave ingredients to give you the details you need.
Bupropion hydrochloride is a prescription medication that goes by the names of Aplenzin and Wellbutrin XL.
What is it Supposed to Do?
It is used to treat depression and prevent seasonal affective disorder. There are other uses, including the treatment of attention deficit hyperactivity disorder (ADHD), and smoking cessation. It may also be used with other mood stabilizers to treat bipolar disorder, and may be used to treat anxiety in people with depression. 
There are a number of clinical studies available on this medicine, because it has been tested for FDA approval. One of the main side effects associated with Bupropion is weight-loss.
This medication is available by prescription only, and may also be marketed under the name Revia. It’s designed to treat opiate addiction, and used as part of a more comprehensive treatment program. The medication may also be used to treat alcohol abuse.
What is it Supposed to Do?
It works in the brain to prevent the affects of opiates – pain relief and feelings of well-being from taking place. It also works to decrease the desire to use opiates.
There are a number of studies on this medication, though none are directly tied to weight-loss. According to a study published in Journal of Clinical Pyschopharmacology, “Although both groups showed decreases in smoking urge scores through treatment, the reductions were larger in the naltrexone group, with an average Brief Questionnaire of Smoking Urge scale score decrease of 13.6 ± 1.17 points in the naltrexone group compared with 9.58 ± 1.39 points in the placebo group (β [SE] = −4.37 [2.05], P < 0.05).”
Clinical research is an important part of the equation when it comes to choosing a diet supplement. You may want to take a look at a product like Leptigen, which is formulated with clinically tested ingredients, and available without a prescription. Click above to learn more.