Updated: 04/18/2017 - Site operated by Leptigen

Dinitrophenol Review - Does This Weight-Loss Pill Work?

  • 9 User Comments
  • Rating: 2.6. From 25 votes.
By Summer Banks Mar 16, 2017

The results of my research into Dinitrophenol were somewhat surprising. We at DietSpotlight conducted an in-depth review, examining the side effects, ingredients, scientific research and level of customer service. We also sorted through hundreds of user comments and remarks that are posted online. Lastly, we summed up all of the facts and feedback we found in order to give you the bottom line.

Dinitrophenol Readers: Click here to find out why we're giving away samples of our product, Leptigen.

What is Dinitrophenol?

To begin with, Dinitrophenol ingredients simply include DNP or 2, 4-Dinitrophenol. This is not a supplement with several components, but rather a single substance that is sometimes used for weight-loss purposes. The claim is that it helps increase metabolism, which results in significant weight reduction. No special diet plan or fitness regimen is needed. You simply take this product daily (200-400 milligrams) and can potentially see fast results. Some serious weight lifters and bodybuilders use DNP.

We are not sure when Dinitrophenol first emerged. However, we do know this substance affects mitochondrial ATP production. This in turn increases the body’s production of heat. There is some user feedback posted online to help you gain a better understanding of DNP, but read on…

Adverse Effects – “Is It Worth It?”

The first concern we have is Dinitrophenol side effects. According to our Research Editor, “DNP can cause serious adverse reactions, such as breathing problems, irregular heartbeat, and even death. This is cited on websites like NCBI.gov.”

One person stated, “Warning. DNP is bad stuff. I took care of a patient who took DNP. He died. And it wasn’t a pleasant death either. This stuff has been used as an herbicide, explosive, wood preservative, and photographic developer. It is not for humans.”

On the other hand, a different user commented, “Been taking this a few days. Wow, makes me really hot.”

Another posted, “Going to be honest, this stuff is dangerous. Causes insomnia too.”

Customer Warnings – “Be Careful”

There are quite a few customer warnings about Dinitrophenol. In fact, one person revealed, “My son died taking this. Don’t use it. It killed him 8/31/2015.”

Then again, a different user had this to say, “Does increase your body’s core temperature. But, you need to be prepared for some side effects.”

“A bit too intense for me. Thought it would help me cut fat, but no thanks,” mentioned another individual.

Our research has revealed that if there is some particular part of a weight-loss pill or diet program that is especially troublesome (adverse effects, customer warnings, steep price) the probability of real results for the long term is low. In other words, if Dinitrophenol does in fact cause serious side effects in a lot of people, this could be a deal breaker.

The Science – “Is There Any?”

Here at DietSpotlight, we need to see some actual research that supports the product we’re investigating. Unfortunately, though science does support claims of increased heat production and weight-loss, taking even a small amount too much can lead to death.

The Bottom Line – Does Dinitrophenol Work?

Now the moment you’ve been waiting for. This is our bottom line on Dinitrophenol. First off, we appreciate that this substance can potentially elevate metabolism. But we have some serious concerns about it because it can cause major adverse reactions and death. Also, we’re very leery of this ingredient because of the discouraging customer comments we found posted on the web.

If you’d like to get rid of some pounds, then we encourage you to go with a product that contains clinically tested ingredients for weight-loss, does not cause any dangerous or deadly reactions and is supported by positive user feedback.

Among the best products we’ve seen this year is one called Leptigen. Its formula is a proprietary blend of four key ingredients, which have been shown in published clinical research to help accelerate fat loss and boost metabolism. We can’t find any discouraging user reviews online, and comments around the web indicate people are seeing great results.

The makers of Leptigen are so confident in their product they’re offering a Special Trial Offer, which is very encouraging.

Previous Dinitrophenol Review (Updated January 26, 2010):

The current weight loss market is loaded with supplements that contain "key active ingredients." This is where Dinitrophenol comes into the picture. It's a bit unclear whether or not this substance is only for prescription weight reduction products or not. After doing a bit of online research, it appears that Dinitrophenol, which is also commonly referred to as DNP, is used for weight loss because it aids the user's metabolism. However, there are some side effects that can occur with this ingredient. The key is consulting a real physician before ever attempting to take DNP. According to certain online sources like dnpweb.com, Dinitrophenol "accomplishes an outstanding increase in metabolic rates" by inhibiting the "F0F1 ATP Synthase Molecule," which is clarified to be located inside the mitochondrial wall. Now, you may be wondering what exactly that means for individuals who're struggling to shed excess body fat. Well, by taking Dinitrophenol and maintaining the same diet plan, you may be able to burn of up to "20-40 percent more calories" each day. This is without even adopting a regular fitness routine. Although I found two online sources that sold Dinitrophenol-based supplements, both appeared to be discontinued. It's common for DNP to be used by bodybuilders.



Product Features

Dinitrophenol or DNP is a substance that's sometimes used for weight loss. Although it's claimed to be very effective at increasing metabolic rates in some users, there are certain side effects that often apply to this fat reduction ingredient. These can range from the body overheating (this refers to the user's body cooking from the inside), to insomnia, to dehydration, to carcinogenesis, to sweating and discomfort, to yellow bodily fluids, to muscle soreness, to carbohydrate cravings, to allergic reactions. Naturally it's crucial to take the correct dosage of Dinitrophenol, which is generally directed by a physician. A specific period of time will likely be addressed for taking this weight loss drug, which means that it should not be taken any longer unless directed by a doctor.


  • Dinitrophenol is claimed to seriously boost the rate in which foods are metabolized.
  • Up to 20-40 percent of the user's calories may be burnt off by this weight loss product daily.


  • There is no official website discussing this active component.
  • There are a number of potential side effects that go along with taking DNP, which involve the body overheating (this refers to the user's body cooking from the inside), insomnia, dehydration, carcinogenesis, sweating and discomfort, yellow bodily fluids, muscle soreness, carbohydrate cravings, and even allergic reactions.
  • It appears that some Dinitrophenol supplements have been taken off the market.


When it comes to substances like Dinitrophenol, it can be difficult to determine whether or not the product is right for you. You must keep in mind all of the potential side effects that go along with this weight loss drug. While DNP may lead to boosted metabolic rates, you need to remember that this substance can result in much more serious health afflictions, which may make it not worth taking.
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Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Leptigen, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 2.6. From 25 votes.
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User Comments

9 Comments on "Dinitrophenol Review"


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my son died taking this don’t use it it kills


my son died taking this don’t use it it killed him 8/31/2015


please please do not take this. Chris Mapletoft, my oldest childhood friend took these pills, which tragically killed him this summer. he was a cleaver guy, who would not have taken them had he been aware of its disastrous affects, please do not be fooled by the lack of negative information you may find about these pills.


My son’s friend at school died from taking DNP on June 18th this year, just after his last exam. It is a vile, vile substance. Please don’t take it. If you need to lose weight, just grit your teeth, eat properly and exercise – it worked for me.


My friend died taking this compound. It is an incredibly toxic compound. They essentially cooked from the inside. Avoid at all costs.



Ewart Padgett

DNP works by interrupting the Krebs cycle of metabolism, causing some of the food energy to be thrown off as heat, increasing body temperature. For that reason dosage must be tightly controlled to prevent lethal overheating, particularly during exercise, or hot weather. Its use depletes some forms of the thyroxine the body produces, requiring supplementation to maintain optimal body function and weight loss. One can easily and safely lose 100-150# in a year.


What colour is dnp and does it work after the 4th pill and will it work without a proper diet and exercise or must one folloe a diet and exercise daily?????????????


Its yellow, and with anything, it will work much better with diet and exercise.