Updated: 04/18/2017 - Site operated by Leptigen

GNC Triflex Review - Does This Joint Support Formula Work?

  • 39 User Comments
  • Rating: 3.4. From 79 votes.
By Summer Banks Mar 16, 2017

97% of people are just looking for a product that works. Yeah, we’re not sure about the other 3%, either. This time we decided to take a close look at GNC Triflex via ingredients, side effects, customer service and clinical research. We read as many reviews as we could find. Then, we condensed it all to give you the bottom line.

GNC Triflex Readers: Click here to find out why we're giving away samples of our product, Leptigen.

What is GNC Triflex?

First off, GNC Triflex is a joint support formula that contains glucosamine HCL, chondroitin sulfate sodium, MSM and hyaluronic acid. The label says to take three capsules daily with food, so we assume that means one with each meal. You’re supposed to notice improvement in flexibility in the joint. Both men and women can take the supplement.

GNC, General Nutrition Centers, is the company that makes GNC Triflex. The roots of the business stretch back to 1935. The official website sells the supplement, but you can also buy it from outside retailers. We like that many users are happy with the formula and the ingredients are commonly used, but read on…

Results – “Lacking?”

The first issue we came across with GNC Triflex ingredients is a lack of results. “If we found just one or two reports of the formula not working that would be one thing,” says our Research Editor. “However, we found many more than that.”

  • “After 4 weeks my old joint pains came back,” said one user.
  • Another offered, “This product did not alleviate my joint problems.”

On the flip side some users were happy with the results.

  • “I tried several supplements and found this to be superior,” was one experience.
  • Yet another claimed, “It reduced my swelling and pain.”

Side Effects – “Really a Problem?”

We found reports of GNC Triflex side effects all over the place.

  • As one user put it, “This product caused me extreme abdominal pain within a week of using.”
  • Another said, “Triflex caused me severe joint and muscle pain the entire time I took them.”

However, as is always the case, we found some good reports, as well.

  • “Taking them is like taking a pain pill without any side effects,” one user offered.
  • “Have been ordering this for 2 years and never a problem,” shared another.

So, through years of research we’ve found what looks like a connection between something small, like mediocre results, and a lesser chance of long-term use and results. If GNC Triflex is not the strongest joint support on the market, the customer won’t stick around for long.

The Science – “Any Clinical Evidence?”

Here’s where you separate supplements. The main ingredients in GNC Triflex, glucosamine and chondroitin, were part of a four-year trial called GAIT. The results of the study were simple, there was no statistically significant difference in pain or joint health between the active and placebo group. At DietSpotlight we want science to prove a product’s worth. This time it proves the opposite.

Does GNC Triflex Work?

Are we heading over to the GNC website for some Triflex? Well, we like that common, and generally considered safe, ingredients are used, but we have strong reservations because science says glucosamine and chondroitin don’t work. That could be the reason for disappointed users.

If you’re ready to fight that joint pain, you may want to try out a weight-loss supplement with clinically tested ingredients. Losing weight can help relieve stress that’s causing your pain.

Among the best products we’ve seen in 2016 is one called Leptigen. It’s made with 100% clinically tested ingredients, gives you quite the bang for your buck and it’s backed by some strong customer reviews.

Plus, we’re thrilled that the makers of Leptigen are so confident in the formula that they’re offering a Special Trial Offer, nice touch.

GNC Triflex Questions & Answers:

After examining hundreds of user comments about GNC Triflex, we made this helpful FAQ.

What are the side effects of GNC Triflex?

According to some customer reviews, GNC Triflex side effects include abdominal pain, upset stomach, muscle pain and headache.

What are the ingredients in GNC Triflex?

GNC Triflex ingredients include acacia catechu wood/bark extract, Chinese skullcap root, uc-ii natural collagen concentrate and hyaluronic acid.

Does GNC Triflex work?

There’s limited information relating to the effectiveness of GNC Triflex as it relates to improved joint health. Unfortunately, we didn’t locate any studies linking the supplement to weight-loss, although overall wellness could lead to improved fitness, resulting in you losing weight.

If weight-loss is your ultimate goal, you may want to take a second look at GNC Triflex and consider a supplement like Leptigen, which contains some clinically-tested ingredients and has been shown to work.

How much does GNC Triflex cost?

GNC Triflex costs $9.97 for a 30 day supply. If you’re a gold member, you are charged $7.98.

How should I take GNC Triflex?

You should take one GNC Triflex capsule per day. One bottle lasts 30 days.

Can I take GNC Triflex if I have a health condition?

Women who are pregnant or nursing, those with health conditions, anyone taking prescription medications or under 18 years of age should contact a healthcare professional prior to using any dietary supplement, including GNC Triflex.

What do users like about GNC Triflex?

We found that some users liked that GNC Triflex was reasonably priced.

What do users NOT like about GNC Triflex?

Some users didn’t like that they didn’t notice any changes while taking GNC Triflex.

How do I contact the GNC Triflex customer service department?

You can contact the GNC Triflex customer service department by calling 1-877-462-4700, sending messages through the feedback form or by mailing letters to GNC 300 Sixth Ave. Pittsburgh, PA 15222.

Does GNC Triflex contain stimulants?

No, GNC Triflex doesn’t contain stimulants.

Will I need to diet while taking GNC Triflex?

No, you don’t need to diet while taking GNC Triflex. Although a healthy eating plan could improve overall wellness and help you lose weight.

Does GNC Triflex come with a guarantee?

GNC Triflex comes with a 30-day money-back guarantee.

Do you know of any special deals or discounts on GNC Triflex?

There are deals and discounts on GNC Triflex, if you sign up for the gold membership. However, our readers have wanted to improve overall health and wellness, as well as lose some weight, so they’re taking advantage of Leptigen’s Special Trial Offer, which is simply the cost of shipping and handling. Click here to give it a go.

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Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Leptigen, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 3.4. From 79 votes.
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User Comments

39 Comments on "GNC Triflex Review"


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Have had knee pain for about the past 10 years. Was so bad that I couldn’t jog a block. x-rays showed onset of deteriorated cartlidge and osteoarthritis. Started off with basic Gluc – chondroitin supplement and started seeing some improvements. Pain came back after a couple years. Have tried a number of supplements over the years and found that Tri-Flex extra strength seemed to work the best for me. There is nothing in this product that should increase your joint pain. Don’t think of it as a miracle cure that within a week will stop your pain. It is an ongoing management system. Probably the biggest improvement I did was lose 30 lbs. There is nothing in the supplement which should increase your joint pain (If so see your doctor as you may have a bigger problem going on.


This may seem a bit bizarre and isn’t a hoax. I bought the liquid TriFlex and after a few days started having violent nightmares. I was taking the recommended dose of 2 Tbls plus 2 mini fish oil tablets. I only weigh 105 lbs and am 72 years old.. Has anyone ever experienced this? Could this dose be too strong for me?

Hi Deanne. We’ve not heard mention of violent nightmares from anyone using GNC Triflex. We suggest you talk with your doctor about this, especially if it continues.

ray barrett

Relieved joint pain but caused considerable amount of hair loss. Discontinued the use of Triflex.


Hi, I am 35 years old & suffering from patellar tendentious from last 1 year.. My gym coach suggested me to go for tripple strength fish oil mini, So i purchased it while purchasing i was suggested to take triflex as a combination along with this so without thinking much i purchased it also.


i’de like to know where i can buy this?pls reply to my asap.Thank you


Hi Crystal! For more information on where to purchase this product, please refer to the GNC Triflex official website.


Have recently began battling gout. Flare up time and nothing is helping, GF bought this yet I thought shellfish was BAD for gout? Please advise if I should try, pain is at 11 and I need help ASAP


Hi Swamp. Please make sure to consult with your physician before starting GNC Triflex.

Your Name

I want to know the expiry date of Triflex dietary supplement tablets which is packed on January 2015

Hello, the expiration date should be stated on the actual bottle itself; if not, please contact the GNC Triflex customer service department.

Marie Dyer

I have started using GNC TRIFLEX and I am getting severe joint pain in my knee area. so I stopped using it

JANE Potter

I have started taking it also and I have severe joint pain in my knee area-so I will stop using


Should I be taking this if I am 20 years old and not having any joint pain. I would take it for preventive measures. I am in the military so I move a lot and also workout everyday.

Devon (Editor)

There shouldn’t be a conflict Javier. See what your doctor says. Good luck.

Merle Palmer

Do you have to eat a healthy diet for Triflex to be effective.

Candace (Editor)

A healthy diet is always recommended.

Your Name: Nikolai Peronius

This product has helped my joint pains but after taking the maximum dose for a year I am concerned that it might affect the liver or kidneys. I am 76 years old. Please reply. Thank you

Cameron (Editor)

Acute liver damage was found in rats who were given Methylsulfonyl-Methane (an ingredient in Triflex) and CCI, however we haven’t heard these reports in humans nor do we expect to. However you should always ask your doctor before taking any dietary supplement.


My orthopaedic dr recommnded this to me rather than pure glucosamine supplements (Cartril/Vyartril-S) and suggested I should have some improvement after 1-2 months. I have been taking it since 10th March 2016, until now do not feel any improvement. I have osteo-arthritis in my left knee, Any advice / feedback? thanks


is GNC Triflex comes under drug dopping? if yes up to what dose its safe?

Stephen (Editor)

1,500 mg of glucosamine and 1,200 mg of chondroitin is the constituent safe dosages.

Ken palmer

Can i take ibuprofen while taking triflex

Stephen (Editor)

Ken, mixing pills can be a bit tricky. Just don’t take them at the same time. Ask your doctor and inspect the label.


I am 45 years old. Had been an active tennis player in my teens. Never had any problem in my joints till now. My right knee started to buckle. X rays showed cartlidge loss and narrowing of space between the bones. Doctor recommended injection of some fluid in the knee to improve mobility. Instead i took triflex. I am taki g it for the last 6 weeks now. It has started showing the diffetence in the first week. No pain and I am moving around comfortably. Also taling o.ega 3 dose with it. EXCELLENT.

Sushma Khandelwal

I have started taking this product but I can see swalloing under my eyes, should I stop it or continue.

Your Name

I just bought a bottle of Trifled because I have arthritis on my left leg and I am in a lot of pain I just hope it helps me

Lee T.

After having major knee reconstruction over 14yrs ago, I knew my knee would begin to deteriorate due to the damage and scar tissuing. Surgery was a great success but aging and me not slowing down, degenerative arthritis has begun. I was introduced to Triflex at my local GNC. The employee told me it was the best formula for joint pain. I was skeptical at first but wanted to give a try. I was amazed after the first month. Pain and stiffness was nearly gone. I was impressed and have passed this product onto friends. They also are impressed and thankful I told them about Triflex. I use the liquid form. Give it a try.


That sounds suspiciously contrived.


.estoy tomando triflex en tiempo de un mes sus resultados me han sido extraordinarios , ya que no tengo el cartílago De mi cadera y sufría de esteoartritis , estas vitaminas han sido unos de los mejores que he tratado !! Sin efectos , lo recomiendo

Batoul Ali Osman

Thanks,I have started taking Triflex nine months ago. I am feeling very good and comfortable.The pains reduced 75%. But as am residing in Saudi Arabia. I cant get same formula in GNC Jeddah, KSA.Pls assist. how can I get it regularly.
Thank you.

Your Name