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Lipase Review - 18 Things You Need to Know

We hear a lot of buzz about Lipase, so we decided to take a close look at the enzyme, possible side effects and clinical research. To learn more about how people use the product, we read hundreds of reviews. Then, we gathered all the information and condensed it to give you the bottom line.

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What is Lipase?

Lipase is an enzyme released into the digestive tract which aids in breaking down the lipids in your diet. Hence, it is categorized as a digestive enzyme.

Based on this difference there are three major types of lipases; pharyngeal lipase, produced in the oral cavity, hepatic lipase, produced in the liver, and pancreatic lipase, produced in the pancreas.

These lipases are active in different areas of the digestive tract.

Pharyngeal lipase is active mostly in the stomach, pancreatic lipase at the duodenum or beginning of the small bowel, while hepatic lipase regulates lipid levels in the circulating blood.

Concentrations of lipase enzymes in the blood can be used to diagnose many conditions related to the digestive tract, especially issues of the pancreas. Lipase tests are considered a very sensitive and specific test for diagnosing pancreatic conditions.

Apart from the risks related to the pancreas, conditions like intestinal obstructions, and cystic fibrosis, lead to elevated levels of lipase and this can be used as a diagnostic test for the above conditions as well.

Does It Work?

  • Current Drug Metabolism — “enzyme supplementation therapy may play an important role in several digestive and malabsorption disorders, such as EPI and lactose intolerance.”
  • Journal of Medicinal Food — “clinical evidence supporting the safety and efficacy of MEC as a dietary supplement in the management of dyspeptic symptoms in patients with FD.”
  • PLoS One — “findings suggest that the use of the HF diet can be a simple and effective tool that can decrease gut permeability”

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How Did Lipase Start?

Lipase was first discovered by the French physiologist Claude Bernard in 1856. Earlier on, animal pancreatic extracts were used to produce lipase for commercial applications.

Afterwards, scientists started exploring plant and microbial sources for the extraction of lipase. Aspergillus oryzae is one such microbial fungus used for lipase extraction.

This exploration became more intense as the demand for lipase grew as a commercial product.


Lipase Claims

Lipase enzyme dietary supplements are in the market under different brand names. These products claim to be effective in improving fat digestion thereby reducing the risk of cardiovascular issues while helping users manage their weight.

The companies who manufacture these supplements encourage using products with additional lipase, claiming that it promotes cholesterol balance in your body, aids in healthy bowel movement, improves gallbladder health, and is essential for healthy skin.


Lipase Ingredients

Lipase supplements mainly contain the enzyme lipase synthesized from a fungus called Aspergillus oryzae.

lipase digestive enzyme

In addition, they contain Amylase which is responsible for the breakdown of carbohydrates, and a Protease blend which consists of acid, alkaline and neutral protease enzymes plus peptidases with an array of specificities to certain peptides.

Apart from the enzymes, these supplements contain cellulose and water:

  • Lipase
  • Amylase
  • Protease blend
  • Cellulose
  • Water

All of the enzymes included in the supplements are able to act on a wide range of pH values, thereby making them effective in many areas of the digestive tract.

Why Take It?

Why Do Healthy People Take Digestive Enzyme Supplements?

Many consumers who opt for digestive enzyme supplements are middle-aged or older.

They may feel that their digestive tract is not working optimally because they have more bloating and gas. Some may feel that some of their illnesses are due to the fact that they don’t absorb consumed nutrients efficiently.

Many young users, in their 20s and 30s, believe that these supplements burn fat and make you slimmer and more attractive.

However, from a scientific point of view, there is no concrete evidence to draw firm conclusions on any of these claims. They may work for some and not for others.

Does It Work?

Does Lipase Work?

Lipase supplements are generally considered effective in regulating lipid levels in obese individuals.

This type of supplement receives mixed reviews, with some users finding it beneficial while others do not. This is typical of most supplements.

Lipase breaks fat down and that is a fact. If someone with a lipase deficiency takes a lipase supplement, he or she will say that it worked.

lipase breaks down fat cells

However, from a research standpoint, there is minimal to no evidence to say that lipase supplements are effective in promoting weight loss.

For users looking for a reduction in his or her weight with lipase supplements, there is no good news. It is advisable for them to resort to other clinically tested and research-proven supplements available in the market.

Benefits and Results

Lipase Benefits and Results

Lipase is a beneficial enzyme for your body as it breaks down lipids and regulates their levels in the blood, according to StatPearls Biochemistry, Lipase.

Weight Loss

Details on Lipase and Weight Loss

Digestive enzyme supplements are known to cause weight loss. Considering the fact that lipase breaks fat down, it is safe to assume that it acts as a potent weight loss promoter. But, there are both positive and negative aspects of this claim.

First, the enzyme lipase acts on the fat contained in the food you eat and the fat that is already stored in your body. The lipase supplements you take orally will remain in your intestine and digest the fat you eat.

If the lipase supplement reached your cells at all, it would be a very small percentage.

So, if you are obese or overweight, lipase deficiency might not be the cause.

In addition, contrary to the claims that lipase supplements in the market make, some percentage of the lipase in the supplement you take is bound to be destroyed in the acidic environment of the stomach because lipase is not an acid-tolerant enzyme.

Despite all of this negativity, lipase has been able to hold its ground as a weight-loss promoting agent thanks to some scientific discoveries.

Scientists have been able to manipulate portions of the molecular structure of digestive enzymes including lipase, to switch them on and off. This means that the enzymes that work for only a few hours will be able to exert their effects longer as required by different individuals.

Deficiency Symptoms

Symptoms Of Lipase Deficiency

  • Gallbladder pain
  • Urinary incontinence
  • Cystitis
  • Bladder problems
  • Lactose intolerance

lipase deficiency constipation

  • Diarrhea or constipation
  • Joint pain
  • Varicose veins
  • Prostate problems
  • Vitamin deficiencies
  • Weight gain

How to Take Lipase

These digestive lipase supplements come in capsules. The usual recommendation for weight loss and fitness purposes is to take one capsule with each meal.

This dosage can be subject to change depending on your healthcare professional’s advice and prescription.

The standard dosage of lipase supplements for an adult is 6000 lipase active units, or 1 to 2 capsules, 3 times daily on empty stomach about 30 minutes before meals.

When considering lipase as a treatment option for certain conditions, there are standard doses.

For example, to treat digestion issues that come with pancreatic insufficiency related to cystic fibrosis, the usual dose for adults is 4500 IU per kg per day. For children, it is 5100 IU per kg per day.

It is best practice to start lipase with a lower dose and work your way up until there are evident results. However, you should not exceed the above mentioned standard doses without a recommendation from your healthcare provider or practitioner.

Lipase for all the above conditions is taken orally.

Side Effects

Potential Lipase Side Effects

According to Core Evidence, lipase supplements are known to cause side effects such as gastrointestinal problems, and neurological symptoms.

Some potential side effects of lipase supplements include:

  • Increased heartbeat
  • Sweating
  • Agitation
  • Nervousness
  • Sleep disturbances
  • Enlarged pupils
  • Nausea
  • Diarrhea
  • Stomach pain
  • Abdominal cramping

If you experience any of these side effects while taking a lipase supplement you should seek medical attention immediately.

Product Warnings

Lipase Product Warnings

Lipase and lipase products come with a few warnings.

It is advised not to use lipase during pregnancy or breastfeeding because there is no sufficient research or evidence to support the safety of its use during that time.

Lipase Test

Lipase Test

A lipase test is done to measure the lipase enzyme levels in your blood. It is important, especially in conditions like pancreatitis, and cystic fibrosis, to come to a diagnosis, to plan the appropriate treatment, and to assess the patient’s response to the treatment given.

Patients must fast for 8 to 12 hours prior to the test. You shouldn’t consume anything except for water during this period.

lipase test

The health professional will draw a sample of blood from one of your veins and send it to the laboratory for analysis.

Drug Interactions

What Are The Drugs That Can Elevate Lipase Levels?

Abnormal levels of lipase can be seen with the use of common drugs such as:

  • Thiazide and loop diuretics
  • Opiates like codeine and morphine
  • Meperidine
  • Birth control pills
  • Cholinergic drugs like pilocarpine, bethanechol and neostigmine

Lipase Interactions

Lipase supplements can cause interactions with other supplements or digestive enzymes.

Lipase inhibitors like Orlistat can block the action of lipase supplements and make them inefficient. So, if you are planning on taking such supplements, it is better to consult a healthcare professional beforehand.


Lipase Alternatives

Lipase supplements may be a good replacement for the enzyme is a lipase deficient person or individual suffering from a condition that requires extra lipase supplementation.

For the average person who is fitness conscious, lipase supplements may be a bit much.

The best alternative for this type of individual is opting for natural sources of lipase such as raw nuts, whole grains, legumes, sprouted seeds, raw fruits and raw vegetables. These natural dietary sources are also rich in amylase and protease enzymes, hence they become excellent natural sources of digestive enzyme supplements.

Another important factor to consider in this regard is the fact that however much you ingest natural food that contains digestive enzymes if your body does not provide the optimal condition for them to act, the desired outcome will not be achieved.

You can solve this by eating raw fruits and vegetables. When you heat and cook vegetables and other rich sources of enzymes at boiling point, many enzymes tend to degrade.

The next step is to chew your food thoroughly. Chewing thoroughly grinds the food into very small particles and increases the available surface area for the enzymes to act. Also, it gives more time for the glands to secrete the enzymes and for the enzymes to act on food particles.

According to the Journal of Physiology and Pharmacology, the other important factor for better enzyme activity is reducing physical and mental stress. Physical stress due to strenuous exercise, surgery, sleep disturbances or illness can impair the secretion of digestive enzymes in your body.

When your mind is stressed out certain hormone levels elevate. This, in turn, can affect secretion of digestive enzymes from the gastrointestinal tract.

Doing your work according to a routine, planning out things, getting enough rest, giving your body adequate time to recover from illnesses, regular moderate exercise, and engaging in stress-relieving activities like meditation, yoga, and music therapy for an allotted time period, can assist you in increasing the secretion of digestive enzymes and improving their efficiency.

What Users Are Saying

What Users Are Saying

“This is the best enzyme for breaking down fat and absorbing fat. It has helped my dry skin and dry hair tremendously.”

“Digestive enzymes cause people to gain weight and I need to do the opposite.”

“I have a sensitivity to fats in food. These pills help to calm my stomach after eating food with an extra large amount of fat.”

Bottom Line

The Bottom Line – Does Lipase Work?

Should you take Lipase every morning? Well, we don’t see a problem for most people, but the benefit may not be there, so we are left with reservations. Some people praise the results and others claim nothing happened. This one is hit or miss, but we do know it is not ideal for weight-loss. There’s not enough research what the effect of taking too much could be.

For those looking to Lipase for weight-loss, we suggest going with a clinically tested weight-loss program that is backed by tons of positive customer reviews.

Among the best diet programs we’ve seen this year is one called Noom. We like this unique weight-loss system because it offers personalized meal plans, 1:1 human coaching, interactive support groups, and other great health tracking tools.

Plus, the company behind Noom is so confident in their program that they’re offering a free trial offer to all customers.

Learn More About Noom »
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Which products contain lipase?

Products that contain lipase included natural foods like whole avocado, egg yolk, cream, and whole coconut. Lipase is a crucial part of fermentation that takes places with yogurt and cheese. It can also break down fat and free fatty acids in the body.

What is lipase made out of?

Lipase is made from the cells of your stomach and is an important enzyme that promotes digestion. It is effective at breaking down dietary fats into glycerol and fatty acids.

How does lipase work in the body?

Lipase is an enzyme that breaks down glycerol and fatty acids in the small intestine, which is assisted by bile, which is created in the liver. The bile helps to break the fat into droplets that the lipase enzymes can begin to break down before its excreted from the body.

Where is lipase produced in the body?

Lipase is produced in the mouth, stomach, and pancreas and is an important enzyme in the body. It is effective in breaking down fat that is present in different types of food and is later absorbed in the intestines.

What is the enzyme lipase used for?

Lipase is used to digest fat that enters the body. It hydrolyzes the lipids, which is known as the ester bond in triglycerides. It then forms fatty acids and glycerol after the fat is fully digested.

What activates gastric lipase?

Gastric lipase is activated with lingual lipase to create two acidic lipases. It is secreted by the main gastric cells in the fundic mucosa that is present in the stomach. The acid has a pH level of three to six.

What does pancreatic lipase do?

Pancreatic lipase breaks down, also known as hydrolyzes, dietary fat molecules that enter the digestive system while converting triglyceride substrates that are present in oils into monoglycerides. Pancreatic lipase is the primary enzyme in the body and is secreted by the pancreas.

Where is lipase released from?

Lipase is released from the same place where enzymes are produced in the amylase salivary glands, pancreas, and the small intestine.

What organs produce lipase?

The main area that lipase is produced in the body is pancreatic lipase and the pancreatic lipase related protein 2. Both are secreted from the pancreas.

What is lingual lipase and what does it do?

Lingual lipase is a form of a digestive enzyme and is related to triacylglycerollipases. The enzyme is responsible for breaking down fatty acids and hydrolyzing long-chain triglycerides into partial glycerides.

1 Lipase Reviews

  • A. Epp

    I’m on blood thinners is it safe? I have real high tryglicerides please help

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