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Phentramin-D Review - 14 Things You Need to Know

Many people are familiar with Phentramin-D’s claim to help users lose weight quickly without the risk of any side effects. But can we trust those claims, especially when the product lists hordenine and synephrine (which have known side effect potential) in their ingredient list?

Our researchers took a comprehensive look at Phentramin-D — the ingredients, potential side effects, available clinical research, and more. Then, we summarized the information in one article to give you just what you need to decide if the product is right for you.

Phentramin-D can be purchased through their Official Site.

Phentramin-D Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Phentramin-D?

Phentramin-D is a weight loss pill supposedly helping users lose weight quickly without dangerous side effects. The official product website states it’s not a herbal supplement, but says it’s made from “pharmaceutical grade ingredients.” It comes in capsule or tablet form. Lazarus Labs, the makers of Phentramin-D, describe the product as a “nutraceutical compound.”

A nutraceutical is a term for a product made from a food source and is supposed to have health benefits beyond its nutrients.

In the United States, there is no legal definition of nutraceutical.

Instead, products are regulated according to their ingredients and classified as dietary supplements, drugs, food, or food ingredients, and this is what some of the research has to say:

Phentramin-D Competitors

Phenta XT

Phentramin-D Company Profile

Phentramin-D is manufactured and sold by Lazarus Labs. Their company information is:

  • Headquarters: According to the Better Business Bureau, the company is in Cartersville, GA.
  • Founded: 2003, released Phentramin-D in 2007

Beyond that, there isn’t much more information available about them. They do have an affiliate program, but there is no information on how to become an affiliate for the brand.

Phentramin-D ingredients

Other Products From Lazarus Labs

Additional weight-loss and -maintenance support is available through other Lazarus Labs products including:

  • Lazarus Labs Herbal Weight Loss
  • Lazarus Labs Advanced Probiotics

Phentramin-D Ingredients

Phentramin-D contains a proprietary blend of the following ingredients:

  • 2-Phenylethylamine Hydrochloride (PEA)
  • 1,3,7 Trimethylxanthine
  • Hordenine Hydrochloride
  • Synephrine Hydrochloride

2-Phenylethylamine Hydrochloride (PEA)

PEA is a chemical occurring naturally in the body, but can also be created in a lab, according to the National Library of Medicine. Also, we find it in some food sources such as chocolate. It stimulates the central nervous system. PEA is frequently used in supplements for both mood and weight loss, according to WebCentral.

While in the small intestine, PEA is converted to phenylacetic acid. For enough PEA to reach the brain and have an effect, a person has to take a high dosage. Although PEA is commonly used in weight loss products, there’s no evidence it works in this manner.

There isn’t enough evidence to suggest it works for improving mood, either. We would have to agree since we were unable to locate any scientific research supporting it as being useful for either weight loss or mood.

1,3,7 Trimethylxanthine

1,3,7 trimethylxanthine is another name for caffeine. You can find caffeine in coffee, soda, tea, and lots of other things.

It’s probably the ingredient Phentramin-D relies on for its supposed energy-boosting capabilities.

In a study published in the journal Nutrition Reviews, the research concluded, “Of the three substances discussed, caffeine’s effects on cognitive and physical function, mood, and energy are best understood. It is clear that this food/drug enhances these functions when administered in moderate doses.”

Phentramin-D ingredients

Caffeine and Weight Loss

Caffeine is sometimes touted as aiding in weight loss. It allegedly does this by acting as an appetite suppressant and by stimulating thermogenesis.

However, experts at the Mayo Clinic state that there isn’t enough evidence to support caffeine producing any significant or lasting weight loss results.

Still, there is some evidence that suggests caffeine could help you avoid gaining weight. According to the American Journal of Clinical Nutrition, “an increase in coffee and tea consumption…associated with less weight gain.”


Hordenine is a chemical that occurs naturally in many plants, such as barley, algae, and cacti. The Phentramin-D sales site states that it triggers the release of norepinephrine, and this is probably the substance they are basing that claim on.

That’s because it has been associated with adrenergic effects, meaning that it may affect the part of the nervous system that uses epinephrine and norepinephrine to transmit messages, according to Examine.com. However, that effect appears only to have been observed when it is administered intravenously. There hasn’t been a lot of research into the effects of hordenine on the body or its effectiveness as a weight-loss supplement.


Synephrine is also known as bitter orange, according to Phytotherapy Research. It is similar to ephedrine in structure, but it isn’t as strong. The effectiveness of bitter orange for weight loss is somewhat controversial as it can work as a stimulant, but results aren’t spectacular.

What Does Phentramin-D Do?

Does Phentramin-D Work?

Phentramin-D allegedly causes quick weight loss and suppresses appetite so that users don’t experience hunger pangs. It also supposedly:

  • Boosts metabolism
  • Increases energy
  • Reduces mood swings

However, the scientific evidence surrounding the ingredients is, at best, insufficient.

The only ingredient with sufficient backing toward doing any of those things is caffeine.

Research shows that it can, at least temporarily, boost a person’s energy. However, is there any need to purchase an expensive supplement just for that? Grab a much cheaper cup of coffee or tea instead.

In addition to the scientific evidence surrounding ingredients in a product, we like to hear from real users about their experience.

The problem here is that there are no reliable third-party user comments regarding Phentramin-D available to review.

There are comments on the Lazarus Labs website, but it’s hard to say if they are real or not since the product maker controls the site.

So, our answer to whether or not Phentramin-D works has to be on the ingredients alone, and we didn’t find enough information that suggests it helps with any significant or long-term weight loss.

UPDATE: As of April 2019, the website for Lazarus Labs claims Member Privileges are coming soon. No date is available for release.

Side Effects

Any Phentramin-D Side Effects?

There are claims Phentramin-D does not cause the following side effects:

  • Moodiness
  • Irritability
  • Fatigue
  • Confusion

However, there’s a chance some may notice side effects from Phentramin-D ingredients, including:


  • Rapid heart rate
  • Agitation


  • Nervousness
  • Nausea
  • Vomiting
  • Increased heart rate
  • Rapid breathing


Phentramin-D possible side effects nausea


  • Rapid heart rate

Bitter orange

  • Rapid heart rate

Phentramin-D Benefits

Phentramin-D is supposed to be similar to the prescription medication but without a prescription. Lazarus Labs claims that taking the pills results in:

  • Rapid weight loss
  • Reduction in calorie consumption
  • Burning fat
  • Appetite suppression
  • Increased energy
  • Increased metabolism

Phentramin-D weight loss

Phentramin-D Weight Loss

While they sell Phentramin-D using impressive claims about losing lots of weight fast, we’re not so sure. Even if it did result in weight loss, the potential side effects sound too risky for us to recommend it to you.

When experts like those at the Mayo Clinic say that an ingredient is too dangerous for them to suggest its use, we cannot tell our readers that taking the product is okay.

Nutrition Facts

Phentramin-D Nutrition Facts

While the makers of Phentramin-D claim it is a nutraceutical, implying it has some nutritional benefit, they don’t make the nutritional information available on the Internet.

Unfortunately, that means we can’t tell you if there’s anything at all of the nutritional value in Phentramin-D.


Phentramin-D Directions

To take Phentramin-D, users swallow one capsule or pill 20 minutes before eating breakfast, and another one 20 minutes before lunch with a full glass of water.

Lazarus Lab recommends that you use the product in combination with a good diet and exercise program. They also indicate not to take the product late in the day as it may cause problems with sleeping.


Phentramin-D Results

Again, we’d like to base our opinion on Phentramin-D’s results on what consumers are saying.

Unfortunately, only the official website sells it, so there are no reliable user comments.

  • Also, we cannot support the company’s claims because we were unable to locate any convincing scientific research that suggests the ingredients could result in shedding excess pounds.


Phentramin-D pros and cons

Phentramin-D Pros and Cons


  • 30-day money-back guarantee
  • Free shipping on all orders
  • Manufactured in GMP and NSF-certified, FDA-licensed, and inspected facilities (according to the official website)


  • Contains caffeine under its scientific name, despite the company claiming it doesn’t
  • Fairly expensive
  • A processing fee of $10.95 per bottle
  • Insufficient evidence that it works
  • Unsafe and possibly dangerous ingredient
  • No reliable user testimonials

Phentramin-D Alternatives

Sure, there are lots of other weight loss supplements out there. Phentramin-D comes right out and says they are an alternative to prescription medications.

We didn’t find substantial evidence to support that it will indeed help with healthy, lasting weight loss.


What Does Phentramin-D Cost?

Phentramin-D isn’t cheap by any means, especially considering that we’re not so sure it works.

A bottle of Phentramin-D containing 60 capsules or tablets costs $67.00.

We prefer that our customers spend their hard-earned money on products that clinical research supports, not ones that are iffy at best.

Phentramin-D cost

Phentramin-D Prices

The company offers an increased discount the more bottles of Phentramin-D you buy. Specifically, the costs are:

  • 1 bottle – $67
  • 2 bottles – $63.50 each (5% discount)
  • 3 bottles – $52.33 each (22% discount)
  • 4 bottles -$51.50 each (23% discount)
  • 5 bottles – $50.66 each (24% discount)
  • 6 bottles – 49.83 each (26% discount)
  • 7 bottles – $49.48 each (26% discount)
  • 8 bottles – $49.13 each (27% discount)
  • 9 bottles – $48.78 each (27% discount)

Also, the official website offers a free bottle of Zanaprin with 2 or more bottles of Phentramin-D.

Is There a Phentramin-D Money Back Guarantee?

Phentramin-D does come with a 30-day money-back guarantee. But, that doesn’t mean you’ll get back every dime you spent on the product.

The company charges a processing fee of $10.95 per bottle.

According to Lazarus Labs’ response to a complaint on the Better Business Bureau website, the processing fee is available in their terms and conditions.

They included a link to their terms of sale, but the link is broken. A search of their site didn’t yield any results.

Therefore, we cannot verify the information about the processing fee.


What Users Are Saying

What Users Are Saying

“I have been using this product about six months and must say I was impressed from day one. It controls my appetite and puts a little pep in my step. It is well worth the money. I would recommend to anyone who is fighting with food issues.”

“I used this product last year and it helped me loose 24 lbs in just 4 months. I reordered it this year and it is not the same. They must have changed the chemicals in it. It was worth the money with the previous ingredients. But now I’m out $157 and a bunch of pills that don’t work.”

“I’ve used Phentramin-d tablets for several years off and on, especially when I want to drop about 5 lbs. which is difficult to do. An avid walker, there’s only so much “diet and exercise” I can do, and as I age, that “over 60 years old” middle body spread is even tougher to lose. Fat stored in my mid section gradually (as opposed to rapidly) gets smaller over a period of 30-60 days when using Phentramin-d tablets. Rapid weight loss rarely stays off. Sensible, slower loss of weight tends to KEEP the weight off and with the help of Phentramin-d tablets, my appetite is diminished, making it easier to lose the excess weight. Energy remains at a high level and you don’t feel sluggish, nor do you feel that “nervous energy” that you get from other so-called diet pills and drugs. Give Phentramin-d tablets a try. I’m sure you’ll love the results as much as I do.”

Bottom Line

The Bottom Line On Phentramin-D

After all of our research into the ingredients and possible side effects, we’ve formed a solid opinion about Phentramin-D. First, we will give Lazarus Labs credit for acknowledging that a healthy diet and exercise are necessary for weight loss. We also like that they do offer a money-back guarantee, even if it isn’t a full refund. But, in the end, we cannot recommend the use of Phentramin-D for weight loss. We have some concerns:

  • The potential side effects are serious, and one of the ingredients is considered dangerous.
  • There is no reliable user comments that we can discern results from.
  • There is a lack of solid scientific evidence to support the effectiveness of the ingredients for weight loss.

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What are the ingredients in Phentramin-D?

Phentramin-D contains a proprietary blend including: 1, 3, 7 Trimethylxanthine, Hordenine Hydrochloride, Synephrine Hydrochloride, Yohimbine HCL, and 2-Phenylethylamine Hydrochloride (PEA).

What are the side effects of Phentramin-D?

Consult with your physician before starting any new medications. Side effects could include dry mouth and slight nausea. Also, some of the stimulants in this product could cause jitteriness.

Does Phentramin-D work?

Phentramin-D works just as well as prescription medications without the side effects. Also, you do not need a prescription for Phentramin-D.

What is the price of Phentramin-D?

1 bottle containing 60 tablets or capsules costs $67.00.

Where can I buy Phentramin-D?

You can buy Phentramin-D at Walmart, Walgreens, GNC, eBay, Amazon, and the Lazarus Labs’ website.

Where can I buy Phentramin-D?

Phentramin-D can be purchased using their Official Site.

How should I take Phentramin-D?

It is recommended to take Phentramin-D 20 minutes prior to your meal, twice a day. If you have side effects, take it with your meal instead. This product should be consumed with a proper amount of water. Take it with 8 ounces (1 cup) to wash it down, and 64 ounces per day. Also, make sure to stay on a good diet and exercise program. Avoid taking this product late in the evening due to stimulation properties.

How do I contact Phentramin-D customer service?

There is access to a customer service representative 24 hours a day, 7 days a week. You can call toll-free at 1-888-606-1002, or send an email via TrustedCustomerService@LazarusLabs.com.

Can I return Phentramin-D?

Yes, Lazarus Labs offers a 30-day money back guarantee.

What are the most common complaints about Phentramin-D?

Some of the common complaints are jitteriness and nausea.

10 Phentramin-D Reviews

  • Side affects
    Angie Senter

    what are the side affects of this drug?

    • Maribel (Editor)

      Hello Angie. Among the side-effects that users have experienced are feelings of anxiety, insomnia and getting jittery. Would you like to try a product with less harmful side-effects? Might want to check Dietspotlight Burn, it can boost your energy, burn fat without the unwanted consequences.

  • Alternative for product
    Ronnie (Verified Purchase)

    Looking for a replacement for solo-slim and just took my first dose. Feels like it’s kind of suppressing the appetite like it says it would… but we’ll see. I’ll comment back in a week to report any poundage lost.

  • Cynthia H

    didn’t do anything for me. my appetite was NOT curbed. I had jitters and didn’t like that at all. I actually gained 4 lbs. not a good product in my opinion

  • Loose weight effectively and stave off hunger
    Ronnie (Verified Purchase)

    Well, it’s a week later and I have lost 3 lbs. I will come back in another week to update again. It does stave off hunger, but you do have to put in the effort to not go with cravings.

    • Maribel (Editor)

      Hi Ronnie, congrats on losing 3 lbs! Hope it continues to work for you. If you want to lose weight without being hungry, maybe you could try Dietspotlight Burn. Its backed by real clinical research and users are happy with the results!

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