Updated: 01/08/2018

Phentramin-D Review - 11 Things You Need to Know


In the weeks that led to this review, I figured out whether Phentramin-D actually works. We took an in-depth look at the ingredients, side effects, clinical research, and customer service. Then, we went on to look through hundreds of user comments and reviews to see what people really thought. Then, we summarized and condensed to give you the info you need.

Phentramin-D Readers: Click here to find out why we're giving away samples of our product, Burn HD.

What is Phentramin-D?

Phentramin-D is a weight loss pill that is supposed to help users lose weight quickly without dangerous side effects.

The official product website says that it is not a herbal supplement, but says it is made from “pharmaceutical grade ingredients.” It comes in capsule or tablet form.

Lazarus Labs, the makers of Phentramin-D, describe the product as a “nutraceutical compound.”

A nutraceutical is a fancy term for a product that is made from a food source and is supposed to have health benefits above and beyond the nutrients in the product.

In the United States, there is no legal definition of nutraceutical.

Instead, products are regulated according to their ingredients and may be classified as dietary supplements, drugs, food, or food ingredient. [1]

Lazurus Labs

Phentramin-D Company Profile

Name: Lazarus Labs.

Headquarters: According to the Better Business Bureau, the company is located in Cartersville, GA.

Founded: 2003, released Phentramin-D in 2007.

Beyond that, there isn’t much more information available about them.

We did find their claims about the benefits of their products interesting, though. They say their “products provide several benefits, including:

  • There is no need to consult with a physician for certain conditions.
  • Complete privacy and dignity while addressing personal health issues.
  • No dangerous or unpleasant side effects as found with some alternative products.”

Okay, we’ll get to whether there are potential side effects later. First, let’s address that first claim.

It seems strange to us that any company that is as concerned about the health of its customers as Lazarus Labs claims to be would tell its customers not to consult with a physician.

Phentermin-D Weight Loss

Phentramin-D Ingredients

Phentramin-D contains a proprietary blend of the following ingredients:

  • 2-Phenylethylamine Hydrochloride (PEA)
  • 1,3,7 Trimethylxanthine
  • Hordenine Hydrochloride
  • Synephrine Hydrochloride

Unfortunately, Lazarus Labs does not provide an image of the ingredients label, so we have no idea if they disclose how much of each ingredient is in the product.

We also don’t know if there are other additives in the tablets or capsules.

That means we could only base our research on the ingredients listed on the Lazarus Labs website.

Here’s what we found:

2-Phenylethylamine Hydrochloride (PEA)

PEA is a chemical that occurs naturally in the body, but we can also create it in a lab. Also, we find it in some food sources such as chocolate.

It stimulates the central nervous system. PEA is frequently used in supplements for both mood and weight loss.

The problem with this is that, while in the small intestine, PEA is converted to phenylacetic acid.

So, for enough PEA to reach the brain and have an effect, a person has to take a high dosage. [2]

Although PEA is commonly used in weight loss products, WebMD lists it as having “insufficient evidence” that it is effective for weight loss.

They also say that there isn’t enough evidence to suggest it works for improving mood, either.

We would have to agree since we were unable to locate any scientific research supporting it as being useful for either weight loss or mood. [3]


1,3,7 Trimethylxanthine

While “1,3,7 trimethylxanthine” sounds pretty fancy and scientific, it’s just another name for caffeine.

And, here’s what’s confusing: the Phentramin-D sales website says “You may wonder how a pill can help you amp up your energy levels without providing your body with caffeine or ephedra.”

Wait, did you say without caffeine? Using the scientific name doesn’t make the ingredient NOT caffeine!

Anyway, there’s no secret behind this ingredient. You can find caffeine in stimulants like coffee, soda, tea, and lots of other things.

It’s the go-to energy booster for a lot of people who just can’t start the day without a cup of coffee.

It’s probably the ingredient that Phentramin-D relies on for its supposed energy boosting capabilities.

In a study published in Nutrition Reviews, researchers state, “Of the three substances discussed, caffeine’s effects on cognitive and physical function, mood, and energy are best understood. It is clear that this food/drug enhances these functions when administered in moderate doses.”

Of course, we don’t know what the dosage of caffeine in Phentramin-D is, so we don’t know if it’s enough to be effective. [4]

Caffeine and Weight Loss

Caffeine is sometimes touted as aiding in weight loss. It allegedly does this by acting as an appetite suppressant and by stimulating thermogenesis.

However, experts at the Mayo Clinic state that there isn’t enough evidence to support caffeine producing any significant or lasting results regarding weight loss. [5]

Still, there is some evidence that suggests caffeine could help you avoid gaining weight.

A study in The American Journal of Clinical Nutrition states that “an increase in coffee and tea consumption was also associated with less weight gain.”

They concluded that it is possible that increased caffeine intake might result in a “small reduction in long-term weight gain.” [6]

Another study performed on rats suggested that caffeine might boost fat loss in combination with aerobic exercise.

They saw a reduction in the size of fat cells in rats who were fed caffeine dissolved in saline before swimming. [7]

Hordenine Hydrochloride

Hordenine is a chemical that occurs naturally in many plants, such as barley, algae, and cacti.

The Phentramin-D sales site states that it triggers the release of norepinephrine, and this is probably the substance they are basing that claim on.

That’s because it has been associated with adrenergic effects, meaning that it may affect the part of the nervous system that uses epinephrine and norepinephrine to transmit messages.

However, that effect appears only to have been observed when it is administered intravenously.

There hasn’t been a lot of research into the effects of hordenine on the body or its effectiveness as a weight loss supplement. [8] [9]

Synephrine Hydrochloride

We also know synephrine as bitter orange. It is similar to ephedrine in structure, but it isn’t as strong.

The effectiveness of bitter orange for weight loss is somewhat controversial. WebMD reports that some studies have shown that a combination of bitter orange, caffeine, and St. John’s wort, along with a healthy diet and exercise, might help with weight loss.

However, others have indicated no effect. [10] [11]

Phentermin-D Weight Loss Support

What Does Phentramin-D Do?

Does Phentramin-D Work?

Phentramin-D allegedly causes quick weight loss and suppresses appetite so that users don’t experience hunger pangs. It also supposedly:

  • Boosts metabolism
  • Increases energy
  • Reduces mood swings

However, the scientific evidence surrounding the ingredients is, at best, insufficient.

The only ingredient with sufficient backing toward doing any of those things is caffeine.

Research shows that it can, at least temporarily, boost a person’s energy. However, is there any need to purchase an expensive supplement just for that? Grab a much cheaper cup of coffee or tea instead.

In addition to the scientific evidence surrounding ingredients in a product, we like to hear from real users about their experience with it.

The problem here is that there are no reliable third-party user comments regarding Phentramin-D available to review.

There are comments on the Lazarus Labs website, but it’s hard to say if they are real or not since the maker of the product controls the site.

So, our answer to whether or not Phentramin-D works has to be on the ingredients alone, and we didn’t find enough information that suggests it helps with any significant or long-term weight loss.

Are There Phentramin-D Side Effects to Worry About?

One of the claims that Phentramin-D makes is that it works as well as prescription medications without dangerous side effects. They specifically say that it does not have the following side effects:

  • Moodiness
  • Irritability
  • Fatigue
  • Irregular heartbeat
  • Confusion
  • Drug dependency

Of course, we needed to do our own research to determine what, if any, side effects Phentramin-D might have.


It is listed as “possibly unsafe” by WebMD. It works like an amphetamine and could cause side effects like:

  • Rapid heart rate
  • Anxiety
  • Agitation

It is especially dangerous for people with bipolar disorder or schizophrenia. It may also cause problems during surgery because it affects the central nervous system. Therefore, it should not be taken within two weeks of surgery. [12]


It is “likely safe” when taken in appropriate amounts, but since we don’t know the amount of caffeine in Phentramin-D, we don’t know if the amount is safe. Possible side effects of caffeine include:

  • Insomnia
  • Nervousness
  • Stomach irritation
  • Nausea
  • Vomiting
  • Increased heart rate
  • Rapid breathing [13]

Caffeine is also addictive, which can lead to the following withdrawal symptoms:

  • Headaches
  • Fatigue
  • Drowsiness
  • Depression
  • Irritability
  • Trouble concentrating
  • Nausea
  • Vomiting [14]



It is “possibly unsafe” when taken orally. Possible side effects of hordenine are:

  • Rapid heart rate
  • High blood pressure [15]

The Mayo Clinic suggests that the possible benefits of bitter orange are not worth the risk because the potential side effects could cause serious health problems.

It is similar to a herbal supplement called ephedra, a substance that has been banned by the FDA because it is dangerous.

Bitter orange can cause some of the same problems, including:

  • Rapid heart rate
  • High blood pressure
  • Stroke
  • Heart attack [16]

Remember those side effects that Phentramin-D doesn’t cause according to Lazarus Labs?

Well, we might prefer some of those to the real potential side effects!

Moodiness is nothing compared to a heart attack or high blood pressure.

And, while it might not cause an irregular heartbeat as they claim, a rapid heart rate is just as dangerous.

As for drug dependency, we admit that’s probably too strong a term for a caffeine addiction, but caffeine is still addictive.

Phentramin-D Benefits

Phentramin-D is supposed to be similar to the prescription medication Phentermine but does not require a prescription. Lazarus Labs claims that taking the pills results in:

  • Rapid weight loss
  • Reduction in calorie consumption
  • Burning fat
  • Appetite suppression
  • Increased energy
  • Increased metabolism

They say that using Phentramin-D can result in a 25-pound weight loss in just one month. We’re happy to say that they don’t claim the supplement alone can achieve such results— you need diet and exercise as well. However, that is still a lofty claim for a supplement whose ingredients don’t seem to have scientific backing.

What Does Phentramin-D Do

Phentramin-D Weight Loss

While they sell Phentramin-D using amazing claims about losing lots of weight fast, we’re not so sure. Even if it did result in weight loss, the potential side effects sound too risky for us to recommend it to you. When experts like those at the Mayo Clinic say that an ingredient is simply too dangerous for them to suggest the use of it, we cannot tell our readers that taking the product is okay.

Phentramin-D Nutrition Facts

While the makers of Phentramin-D claim it is a nutraceutical, implying it has some nutritional benefit, they don’t make the nutritional information available on the Internet. Unfortunately, that means we can’t tell you if there’s anything at all of the nutritional value in Phentramin-D.

Phentramin-D Directions

To take Phentramin-D, users swallow one capsule or pill 20 minutes before eating breakfast, and another one 20 minutes before lunch with a full glass of water. Lazarus Lab recommends that you use the product in combination with a good diet and exercise program. They also indicate not to take the product late in the day as it may cause problems with sleeping.

Phentramin-D Results

Again, we’d like to base our opinion on Phentramin-D’s results on what consumers are saying.

Unfortunately, only the official website sells it, so there are no reliable user comments.

Also, we cannot support the claims the company makes because we were unable to locate any convincing scientific research that suggests the ingredients could result in shedding excess pounds.

Phentramin-D Pros and Cons


  • 30-day money-back guarantee
  • Free shipping on all orders
  • Manufactured in GMP and NSF-certified, FDA-licensed and inspected facilities (according to the official website)


  • Contains caffeine under its scientific name, despite the company claiming it doesn’t
  • Fairly expensive
  • Processing fee of $10.95 per bottle
  • Insufficient evidence that it works
  • Unsafe and possibly dangerous ingredient
  • No reliable user testimonials

Phentramin-D Alternatives

Sure, there are lots of other weight loss supplements out there. In fact, Phentramin-D comes right out and says they are an alternative to prescription medications.

We didn’t find strong evidence to support that it will truly help with healthy, lasting weight loss.

What is the Phentramin-D Cost?

Phentramin-D isn’t cheap by any means, especially considering that we’re not so sure it works.

A bottle of Phentramin-D containing 60 capsules or tablets costs $67.00.

We prefer that our customers spend their hard-earned money on products that clinical research supports, not ones that are iffy at best.

Phentermin-D Cost

Phentramin-D Prices

The company offers an increased discount the more bottles of Phentramin-D you buy. Specifically, the costs are:

  • 1 bottle – $67
  • 2 bottles – $63.50 each (5% discount)
  • 3 bottles – $52.33 each (22% discount)
  • 4 bottles -$51.50 each (23% discount)
  • 5 bottles – $50.66 each (24% discount)
  • 6 bottles – 49.83 each (26% discount)
  • 7 bottles – $49.48 each (26% discount)
  • 8 bottles – $49.13 each (27% discount)
  • 9 bottles – $48.78 each (27% discount)

In addition, the official website offers a free bottle of Zanaprin with 2 or more bottles of Phentramin-D.

Is There a Phentramin-D Money Back Guarantee?

Phentramin-D does come with a 30-day money back guarantee. But, that doesn’t mean you’ll get back every dime you spent on the product.

The company charges a processing fee of $10.95 per bottle.

According to Lazarus Labs’ response to a complaint on the Better Business Bureau website, the processing fee is disclosed in their terms and conditions.

They included a link to their terms of sale in the response, but the link is broken, and a search of their site didn’t yield any results.

Therefore, we cannot verify information about the processing fee. [17]

What Users Are Saying

“I have used for 2 days and see a complete difference in my appetite. No jitters.”

“If I double up the dose then I feel it working. Haven’t lost any weight and been taking for 2 weeks.”

“Only good if you work out. If you have inability to be really active, it will not help.”

The Bottom Line on Phentramin-D

After all of our research into the ingredients and possible side effects, we’ve formed a solid opinion about Phentramin-D. First, we will give Lazarus Labs credit for acknowledging that a healthy diet and exercise are necessary for weight loss. We also like that they do offer a money-back guarantee, even if it isn’t a full refund. But, in the end, we just cannot recommend the use of Phentramin-D for weight loss. We have some concerns:

  • The potential side effects are serious, and one of the ingredients is considered dangerous.
  • There is no reliable user comments that we can discern results from.
  • There is a lack of solid scientific evidence to support the effectiveness of the ingredients for weight loss.

If the time has come to jump-start your metabolism, we suggest going with an affordable supplement made with clinically-tested ingredients and not connected to harmful side effects.

Among the best products we’ve seen this year is one called Burn HD. It consists of four clinically-tested ingredients, which have been shown to help accelerate metabolism and ignite fat loss. Our researchers weren’t able to find any comments about harmful side effects, but people are talking about seeing great results.

Also, the company that makes Burn HD are so confident in their supplement, that they’re offering a 2-Week Sample.

Learn More About Burn HD »
Phentramin-D Review
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What are the ingredients in Phentramin-D?

Phentramin-D contains a proprietary blend including: 1, 3, 7 Trimethylxanthine, Hordenine Hydrochloride, Synephrine Hydrochloride, Yohimbine HCL, and 2-Phenylethylamine Hydrochloride (PEA).

What are the side effects of Phentramin-D?

Consult with your physician before starting any new medications. Side effects could include dry mouth and slight nausea. Also, some of the stimulants in this product could cause insomnia and jitteriness.

How do I know if Phentramin-D is right for me?

Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients.

Click here to get your sample of our powerful fat burner today.

Does Phentramin-D work?

Phentramin-D works just as well as prescription medications without the side effects. Also, you do not need a prescription for Phentramin-D.

What is the price of Phentramin-D?

1 bottle containing 60 tablets or capsules costs $67.00.

Where can I buy Phentramin-D?

You can buy Phentramin-D at Walmart, Walgreens, GNC, eBay, Amazon, and the Lazarus Labs’ website.

How should I take Phentramin-D?

It is recommended to take Phentramin-D 20 minutes prior to your meal, twice a day. If you have side effects, take it with your meal instead. This product should be consumed with a proper amount of water. Take it with 8 ounces (1 cup) to wash it down, and 64 ounces per day. Also, make sure to stay on a good diet and exercise program. Avoid taking this product late in the evening due to stimulation properties.

How do I contact Phentramin-D customer service?

There is access to a customer service representative 24 hours a day, 7 days a week. You can call toll-free at 1-855-955-5535, or send an email via TrustedCustomerService@LazarusLabs.com.

Can I return Phentramin-D?

Yes, Lazarus Labs offers a 30-day money back guarantee.

What are the most common complaints about Phentramin-D?

Some of the common complaints are jitteriness, nausea, and insomnia.


Previous Phentramin-D Review (Updated October 20, 2010):

What You Should Know about Phentramin-D

If you are brand new to the world of diet pills, weight loss supplements, exercise programs, and fat reduction products, you may have your work cut out for you. After all, there are far too many to count these days. Then again, this review will help you better understand one of them, which is the formula Phentramin-D. It is claimed to help users shed up to 25 pounds in a single month.

There are two key components incorporated into Phentramin-D. These are 1,3-Dimethyl-pentylamine-hydrochloride and 1,3,7-Trimethylxanthine (both ingredients boost Cyclic AMP, which is a natural process in the human body). These components work to heighten energy levels, and this in turn increases the metabolism. Phentramin-D is also claimed to send signals to the user’s brain in order to relieve the stomach of hunger pangs.

List of  Phentramin-D Ingredients

Proprietary Formulation of: 1,3-Dimethyl-pentylamine-hydrochloride and 1,3,7-Trimethylxanthine.

Product Features

Phentramin-D is a weight loss product that is sold in tablet form. It was developed and manufactured by Lazarus Labs, and can be obtained through a number of online dealers (including the official website). The cost of this over-the-counter diet pill is $67 (60 tablets, or a one-month supply). Like many other supplement formulas available today, Phentramin-D aims to increase the user’s energy levels, suppress appetite, and heighten the user’s metabolism. This means that users should be able to have much more energy throughout the day, burn off fat more quickly, and have fewer hunger pangs. Unlike some other diet products, Phentramin-D is also sold in greater amounts for less money (discounted price when you buy in bulk). For instance, you can purchase a nine-month supply for $439. There are some testimonials for this supplement formula presented on the main website. However, there does not appear to be any 100 percent satisfaction guarantee offered.

Advantages of Phentramin-D

  • There are few active ingredients found in Phentramin-D tablets, which some dieters may appreciate.
  • This supplement formula may suppress hunger.

Disadvantages of Phentramin-D

  • There is no money-back guarantee or refund offered with Phentramin-D.
  • There is no clinical research provided to support this diet drug.
  • The cost of this weight loss supplement is not inexpensive at $67 for a one-month supply.
  • This product may cause sleeplessness.


All on all, Phentramin-D may be beneficial to some dieters trying to lose a few pounds. However, you should keep in mind that this supplement formula sells for $67 per bottle, which will only last one month. Also, it is important to heed the warnings posted for Phentramin-D. This product is not suitable for everyone. Although it is nice to see some testimonials presented on the main website for this diet product, some dieters may be concerned about the lack of refund option for Phentramin-D.

Article Resources
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.

9 Phentramin-D Reviews

  •  Worthless
    Joe (Verified User)

    These pills are worthless, I think all the positive reviews on there site are fake. These pills made me more hungry, and they made me so thirsty I drank tons of water which put more weight on me… completely a waste of money.

  •  2 morning and 2 afternoon
    sandy (Verified User)

    how manny should i take a day? i take 2 at a time but does not really work so should i do 2 morning and 2 afternoon

    • Maribel (Editor)

      Hi Sandy! For detailed product and usage instructions, please refer to the Phentramin-D official website for more information.

  • Side affects
    Angie Senter

    what are the side affects of this drug?

    • Maribel (Editor)

      Hello Angie. Among the side-effects that users have experienced are feelings of anxiety, insomnia and getting jittery. Would you like to try a product with less harmful side-effects? Might want to check Dietspotlight Burn, it can boost your energy, burn fat without the unwanted consequences.

  •  Alternative for product
    Ronnie (Verified User)

    Looking for a replacement for solo-slim and just took my first dose. Feels like it’s kind of suppressing the appetite like it says it would… but we’ll see. I’ll comment back in a week to report any poundage lost.

  • Cynthia H

    didn’t do anything for me. my appetite was NOT curbed. I had jitters and didn’t like that at all. I actually gained 4 lbs. not a good product in my opinion

  •  Loose weight effectively and stave off hunger
    Ronnie (Verified User)

    Well, it’s a week later and I have lost 3 lbs. I will come back in another week to update again. It does stave off hunger, but you do have to put in the effort to not go with cravings.

    • Maribel (Editor)

      Hi Ronnie, congrats on losing 3 lbs! Hope it continues to work for you. If you want to lose weight without being hungry, maybe you could try Dietspotlight Burn. Its backed by real clinical research and users are happy with the results!