Updated: 09/12/2017

Xenadrine Review - Does This Fat Burner Work?

By Summer Banks Aug 10, 2017

If you want the bottom line on Xenadrine, give me just two minutes of your time. We dove deep into the side effects, ingredients, customer service and scientific proof. Experiences from hundreds of users were part of the review. Finally, we condensed to give you the info you need.

Xenadrine Readers: Click here to find out why we're giving away samples of our product, Burn HD.

What is Xenadrine?

Firstly, Xenadrine is a fat burner with green coffee bean extract, garcinia fruit extract, caffeine anhydrous, raspberry ketone, frauenmantle leaf extract, wild olive leaf extract, cormino seed extract and horsemint leaf extract. Each bottle contains 120 capsules and you take up to six daily – two before each meal. The formula is supposed to help you lose seven times more weight.

Iovate Health Sciences is behind Xenadrine. The company started in 1995. It doesn’t look like the original formula is available from the company, but you can buy it from outside retailers. We like the addition of caffeine and the price isn’t bad, but read on…

Results – “Mixed at Best?”

The first thing we felt needed to be addressed with Xenadrine ingredients was results. “We found dieters that did see changes and those that didn’t,” said our Research Editor. “If you’re researching before choosing a supplement that could affect your final decision.”

“My husband is…impressed with this product and swears that it’s helping him lose weight,” one buyer said.

A dieter also claimed, “Gives me that extra energy I’m looking for.”

Not all saw the benefit of Xenadrine fat burner.

“Not as good as the older stuff. Didn’t give me the energy I have come to expect,” one review explained.

Another user said, “Did not have any impact on weight loss at all.”

Xenadrine Side Effects – “Are You Feeling Off?”

Dieters have also reported some Xenadrine side effects across multiple reviews we read. Adverse reactions are not something anyone should settle for.

“Not really impressed with the product. It gave me jitters the first three days,” one buyer offered.

“I often felt very, very nauseated for an hour or two after taking Xenadrine,” as another put it.

There are also though who saw no side effects, though it may not have worked overall.

“It gives me tons of energy, no jitters,” claimed a customer.

One more said, “It provides energy, and has no harmful side effects, but that is all it is good for.”

We’ve found a strong connection between issues, like multiple poor reviews, and a smaller chance of lasting results. If Xenadrine does cause side effects or leaves the dieter wanting for more, they may switch it out for a supplement that’s clinically tested.

The Science – “Is It Proven?”

There’s some caffeine in Xenadrine, so that’s apt to boost energy. Two other ingredients, garcinia cambogia and raspberry ketones, are often considered more of a “fad” than anything else. There’s no conclusive research that shows they can effectively promote weight-loss in most dieters.

The Bottom Line – Does Xenadrine Work?

Did we rush out to pick up a bottle of Xenadrine? Well, we like that all ingredients are listed online and we believe the only side effects would be associated with the caffeine, but we are hesitant to give the thumbs up. The formula is not exactly as strong as it could be and dieters report side effects and lackluster results.

People who’re ready to lose that extra weight may want to leave Xenadrine behind to try out a clinically tested supplement with customer reviews that show nothing but positive results.

Among the best products we’ve seen this year is Dietspotlight Burn. The label shows only four ingredients and all have been scientifically tested, according to the studies we found in peer-reviewed journals. Dieters talk about seeing fantastic weight-loss results in reviews across the web and side effects are minimal, at most.

Plus, Dietspotlight Burn is available as a Special Trial Offer because the makers are so confident in the supplement.

Previous Xenadrine Review (Updated August 20, 2008):

Xenadrine: What You Should Know

Xenadrine, or Xenadrine EFX is a weight loss supplement that is developed and manufactured by Cytodyne. Xenadrine EFX claims to aid in the weight loss process by helping with fat reduction and controlling weight. This diet supplement is available in some general nutrition stores. While the older version of Xenadrine contained Ephedra, the latest version of this diet supplement is stated to be Ephedra-free. Xenadrine EFX sells for $39.95 for 120 capsules.

Like many other dietary supplements, Xenadrine EFX is directed to be taken daily before breakfast, with water, two capsules at a time. Xenadrine EFX is supposed to be a part of a regular fitness regimen and a healthy diet plan in order to be truly effective. Some of the primary active components found in Xenadrine EFX are Vitamin B6 (10 mg), Proprietary Thermodyne Complex (1415 mg), Vitamin C (100 mg), Pantothenic acid (12 mg), Norambrolide (20 mg) and Magnesium (10 mg). Those that take Xenadrine EFX are supposed to be 18 years of age or older. There are some restrictions for Xenadrine EFX that include people with allergies to Tyramine, heart disease, hyperthyroidism, asthma, migraine headaches, renal disease, allergies to chocolate or those afflicted with high blood pressure.

List of Ingredients in Xenadrine

Tyroplex, Green Tea Extract, Vitamim C, Vitamin B6, Norambrolide, caffeine and polyphenols, Seropro (proprietary cocoa extract standardized for PEA [phenylethylamine], tyramine and theobromine), Magnesium, Yerba Mate (standardized for caffeine and methylxanthines), Guarana (standardized for theophyline), Calcium Tribasic, Pantothenic acid, dl-Methionine, L-Theanine, Ginger Root, Proprietary Thermodyne Complex, Isotherm (proprietary blend of 3,3',4',5-7 pentahydroxyflavone and 3, 3',4',7-tetrahyroxyflavone), DMAE, Grape Seed Extract, Talc, Magnesium Stearate and Gelatin.

Product Features

Xenadrine EFX is a dietary supplement that aims to assist both men and women with weight loss. This diet product is marketed in capsule form online and in stores. A healthy diet plan and regular exercise are recommended with Xenadrine EFX. Key active ingredients found in this product are Vitamin B6, Proprietary Thermodyne Complex, Vitamin C, Pantothenic acid, Norambrolide and Magnesium. Xenadrine EFX sells for $39.95 (120 capsules) and 2 capsules should be taken each morning prior to eating breakfast.

Advantages of Xenadrine

  • Xenadrine EFX is now available in an Ephedra-free form.
  • Xenadrine EFX comes in an easy-to-take capsule form.
  • Xenadrine EFX can be easily and conveniently purchased online.

Disadvantages of Xenadrine

  • Xenadrine EFX appears to documented real clinical proof regarding its effectiveness.
  • Xenadrine EFX does not appear to be offered with a 100% money-back/satisfaction guarantee.
  • Xenadrine EFX is clearly not suited for all individuals, due to the number of serious health warnings.
  • There is no free trial sample of Xenadrine EFX offered.
  • There do not appear to be any customer testimonials available.
  • May cause stomach irritation. (See reader comments.)


Like many other diet supplements currently gracing the market, Xenadrine EFX makes a lot of promises. Unfortunately it may be difficult for some dieters to decide on this particular supplement because of the lack of clinical research offered online. Since Xenadrine EFX does come with some warnings, it's wise to consult a doctor before taking this diet drug.

Xenadrine Ingredients and Supplement Facts

Serving Size: 2 rapid-release capsules
Serving Per Container: 30
Amount per Serving% DV
Vitamin C7 mg*
Calcium70 mg*
Xenadrine Blend:488 mg*
Extreme Energy and Metabolic Intensifier Complex**
-Caffeine anhydrous**
-Yohimbe bark extract**
-White willow bark extract**
Powerful Weight Loss Complex:**
-Frauenmantle leaf extract**
-Wild olve leaf extract**
-Cormino extract**

Other Ingredients: Microcrystalline cellulose, gelatin capsule, tricalcium phosphate, dicalcium phosphate, magnesium stearate and silicon dioxide.

We dug deep into the Xenadrine ingredients to give you the details you need.

Raspberry Ketones

Raspberry ketones are the chemicals responsible for the smell of the fruit.

What is it Supposed to Do?

It’s supposed to promote weight-loss, even if you consume a high fat diet.

Clinical Research

A study published in a May 2005 issue of Life Sciences showed that raspberry ketones may help fatty liver in a high fat diet. “RK prevented the high-fat-diet-induced elevations in body weight and the weights of the liver and visceral adipose tissues (epididymal, retroperitoneal, and mesenteric). RK also decreased these weights and hepatic triacylglycerol content after they had been increased by a high-fat diet.”

If you’re looking for a weight-loss supplement, it’s important to find clinical research. You may want to consider Dietspotlight Burn, which is formulated with scientifically tested ingredients.

Garcinia Fruit Extract

Garcinia fruit extract is an extract made from the garcinia cambogia fruit.

What is it Supposed to Do?

It is supposed to help control the appetite and prevent the body from storing fat.

Clinical Research

According to a study published in The Journal of the American Medical Association, “There were no significant differences in estimated percentage of body fat mass loss between treatment groups, and the fraction of subject weight loss as fat was not influenced by treatment group.”

Wild Olive Leaf Extract

This is a supplement made from the leaves of the wild olive plant.

What is it Supposed to Do?

Its high antioxidant value is thought to have a number of health benefits, mainly influencing cell activity.

Clinical Research

According to a study published in the Journal of Nutritional Biochemistry, “This mitochondrial targeting property may provide a possible mechanism for the efficacy of the Mediterranean diet for lowering the risk of cardiovascular disease and also suggests that hydroxytrosol [olive extract] may be used as a therapeutic intervention for preventing type 2 diabetes and obesity.”

Green Coffee Bean Extract

Green coffee bean extract comes from coffee beans that haven’t been roasted, so they contain more of the chemicals known to provide the health benefits of coffee.

What is it Supposed to Do?

The chlorogenic acid is supposed to help promote weight-loss.

Caffeine Anhydrous

Caffeine Anhydrous is a dehydrated form of caffeine. Caffeine is found in tea and coffee, and added to many sodas and energy drinks.

What is it Supposed to Do?

Caffeine is supposed to increase mental alertness and may also boost the metabolism.

Frauenmantle Leaf Extract

Also known as lady’s mantle, this herb grows in England. The extract is used in supplements.

What is it Supposed to Do?

It is used to treat stomach issues such as mild diarrhea and water retention.

Cormino Seed Extract

This comes from cumin, which is a seed that’s commonly ground and used as a spice in cooking.

What is it Supposed to Do?

It is supposed to aid in digestion and issues associated with the digestive tract. It is also supposed to help with hemorrhoids. Early research shows it may be helpful for diabetes.

Horsemint Leaf Extract

Horsemint leaf extract comes from the horsemint plant. Its leaves are used to make medicine.

What is it Supposed to Do?

It’s used as a stimulant, but can also be used to treat digestive problems like gas, and to make menstrual periods less painful.

Is There Anything Out There That TRULY Works?

There’s one supplement that fits the bill. Those who are interested can take advantage of Dietspotlight Burn’s Special Trial Offer, direct from the manufacturer. Click here to give it a shot.

Learn More About Burn HD »
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.

Rating: 3.0. From 61 votes.
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Xenadrine Review

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What are the side effects of Xenadrine?

Xenadrine side effects may include nausea, irritability, anxiety, upset stomach and headache.

What are the ingredients in Xenadrine?

Xenadrine ingredients are green coffee bean extract, garcinia fruit extract, caffeine anhydrous, raspberry ketone, frauenmantle leaf extract, wild olive leaf extract, cormino seed extract and horsemint leaf extract.

How do I know if Xenadrine is right for me?

Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients.

Click here to get your sample of our powerful fat burner today.

How much does Xenadrine cost?

Xenedrine costs $17.07 through third-party retailers.

How should I take Xenadrine?

You should take two Xenedrine capsules per day. Each bottle contains 120 pills, lasting 60 days.

Can I snack between meals while using Xenedrine?

While you can snack between meals while taking Xenedrine, it’s not recommended.

How long can I use Xenedrine?

It’s recommended to use Xenedrine for only 60 days before taking a break.

Does Xenadrine work?

There are studies listed on the Xenedrine website showing some users did notice weight-loss. What we found was the research centered on a small portion of the dieting population and tested focused on one ingredient, not the entire formula.
If you want to lose those extra pounds, think about what Xenedrine offers and consider switching it out with a supplement like Dietspotlight Burn. The supplement contains some clinically-tested ingredients and has been shown to accelerate metabolism and ignite fat loss.

Xenadrine Reviews

Leave a comment or review

  I have seen no difference in a week but will keep trying.
idk about this (Verified User)

ive been doing this for like a week and i have seen no difference): but ill keep trying i guss..


how many pills do i take a day ????? im on my 4th day help


if u r on 4th day u take 2 pils 15 min before each meal from then on…states on the bottle 🙂

  can i take xenadrine while on a low carb diet?

can i take xenadrine while on a low carb diet such as atkins i am on my first two weeks { induction }

Can work

I took this product 6 years ago when it first came out along with a low carb diet. With a daily 30m-1 hr work, I lost 40lbs in 3 months and kept it off.

I think ima stop taking it.
nikki (Verified User)

ummm so im 16…i took this pill 3times today 30minutes before each meal…will anything happen to me??? it also says dong take 5hours before bedtime..if u do take it will anything happen…i think ima stop takin it…

Maribel (Editor)

Hi Nikki! For detailed product and usage instructions, please refer to the Xenadrine official website for more information.

Anonymous (Verified User)

I just started yesterday. I pray it works.

  Can benefit with the health condition?

Thinking about trying but have a couple questions first, please help! I have a seizure disorder but am on medication so i never have any seizures while on my meds. Also, i have had my gallbladder removed. Would it be safe for me to take this? I also have no time at all to exercise. So will this still help me lose weight or would it be a waste of money in my case? Thank you!!!

Maribel (Editor)

Hello Jen. All users are different and can experience different side effects; please make sure to consult with your physician before taking this product to make sure it is safe for you.

Lamar Matava

Wow! This could be one particular of the most useful blogs We’ve ever arrive across on this subject. Actually Wonderful. I’m also a specialist in this topic so I can understand your hard work.

Johnnie Jones

Nice product.


I’ve used this 1 TIME!! And I was way to jittery I couldn’t feel my heart beat, when I stood up I couldn’t feel my legs. I felt sick to my stomach. And i haven’t been able to sleep. I constantly feel like I have to throw up. This was recommended by a friend. I got the xenadrine ultra weight loss and I’m not happy. I’ve lost weight ya but I felt miserable the whole time I was on this product.. I don’t recommend this at all!


Never gonna take this again.


I will never use this product or any diet pill again. I had increased blood pressure, anxiety, depression. I made the mistake of drinking alcohol with them one time and it made matters extremely worse. If you can lose weight by eating right and exercise, do it that way.


I started taking this almost a week ago. The first day I took one pill and did some sit ups. Well my lower abdomen started hurting. I thought it was just because of the sit ups. Having one maybe two days of the abdomen hurting from sit ups is what usually happens it does not take a week for the pain to subside. I need to find a diet pill that is not so full of caffeine. I didn’t feel well and my insomnia has gotten worse. I am not happy with this product.

  Not satisfied, how to contact them ?
Sharon (Verified User)

Made me way too jittery. Have been taking for 30 days and I am just not satisfied with the results. They offer a 100% money back guarantee but no way to contact them on the bottle or the website to get your money back?!?!?!

Stephen (Editor)

Hey, Sharon, try calling 1-888-334-4448 or emailing info@iovate.com.

Randyall ellingsworth

Didn’t work at all for me called u guys gave all info on bottle would like to have my money back thank u very much…

Victoria (Editor)

Hi Randyall. Please make sure to refer to the official Xenadrine website to contact their customer service department in regards to your refund.

  How you can get your refund ?
Donna (Verified User)

I’m not really happy with Xenadrine at all..I’m trying to find how you can be refunded your money that you paid for them but have yet to come up with it any place. Could anybody help me with this please? I know I’ve been having trouble with my stomach since I started taking them but I won’t say it’s because of them but I didn’t have it before. I wish the best to everybody!!

Stephen (Editor)

Donna, try calling 1-888-334-4448 or emailing info@iovate.com.

  Halal or Haram

Is xenadrine halal or haram
What is the source of gelatin
Is it from plants or animals

  we completely concur.
Val Helmus

Greetings. Awesome piece. we completely concur. You have got produced heaps of good points. Have actually a fantastic day.


I have been taking this for 10 days now. I started like it said with one pill before each meal then on the 4th day to take 2 before each meal. I loved the energy but now its day 10 and I am having kidney pain really bad. I drink plenty of water and I don’t know what’s going on. I think I will be stopping these pills which is unfortunate. I am going to try some lemon water and if it doesn’t go away by tomorrow I am not going to take anymore. I have been seeing a difference in weight loss however I have been on a strict diet I mean very strict and I have done this before and gotten the same results. I do not believe this really helps you lose any fat faster than if you dieted properly alone.

  So win win tire murals out gotta to burn off that extra energy.
dj (Verified User)

I’ve been taking it a week now watching insanity work out on YouTube also doing it with the sexy man trainin. I do step ups and bring my son and dog for walks. This gives me extra energy in the day time abs majorly curves my appetite. I’ve noticed a rash on the back of my leg and I stay up at night. When I can’t sleep I get up and exercise though. So win win tire murals out gotta to burn off that extra energy.


Hi DJ, where did you buy it from. I thought Xenadrine EFX was no longer on the market. I’m looking for it. Thanks

  It is working and its does make me a little jittery.
ashes (Verified User)

I am at the week mark and ive lost 5 of the 40 lbs i need to lose. It does make me a little jittery but i just go like mad, workin out 4 days a week and walking a little the other 3 days. I hope this can get me goin, gotta lose some weight for my wedding. 5’5″ 190.

  I've just use it today and will update in a week.
Tryingtogetthinner (Verified User)

I am on my first day of this product. I have drank a lot of water and I have been peeing like crazy. Will update in a week

  Loved the product.
guy (Verified User)

okay so take the pill you all. what don’t kill you make you stronger..or something like that..

  Loved the product.
Demi (Verified User)

Okay so I’m on my first week of this xenadrine, and I love it!
The first day I took it I had taken two pills the very first time though, and got very shakey like (always read the bottle) but after that i be already lost 10 pounds! But I also workout at least three times a week. Left arm got a small heat rash also first day , but other then those two things no negative comments from me ^_^ before taking the pills I had a hard time breathing, and now my airways are much better, I get energy throughout the day! I weighed 185 pounds and now I’m at 170 pounds.. I’m 5`7.. I used to weigh 145pounds not too long ago, but gained a lot of weight over a short amount of time, so I was looking for something to take along with my regular workouts, and I think I found it =)

  Loved the product.
Kate (Verified User)

I don’t feel any speeding effect or increase heart rate. Which is good, woke up this morning with a rash though not sure if I want to keep taking it .it has only been about two weeks

  Is it safe for heart?
unknown (Verified User)

i started taking these. i started to feel really funny and my heart rate sky rocketed. i need to lose alot of weight but i am not convinced these are safe.

  when was this published??

when was this published??

  Loved the product.
Lauren (Verified User)

I’ve been taking this product for one month & it really works! I weighed 153 prior to this product and now am @ 143. I’m 5’6″ and am mostly muscle but just wanted to take off “that last 10 lbs” that diet and exercise can’t seem to get rid of, so this was effective in that regard. I also got the bonus of an energy boost. Bad side effect: I developed a mild rash on my right arm that itched the first few days, but my body got used to the product and quit doing this.
(This is a forum for those who take this product and wish to know the effectiveness or lack thereof NOT for people to put OBVIOUS answers on how to lose weight!!!! Ex:”A good way to lose weight is to just diet and exercise NOT take pills”. If we wanted to know that information we would have looked THAT up but we didn’t so put those kinds of comments where they are relevant. I say this b/c I had to sift through a lot of BS to read what I actually logged on to find!)

  Loved the product.
Seth (Verified User)

I used xenadrine one week every month for 3.5 months, within that time I went from 235lbs to 165lbs. I did 15 min workouts 3 times a week, but i feel like xenadrine did a good portion of the work for me and fast.
Don’t abuse it though, it can get pretty trippy if you do!
I’m currently at 148lbs 9.2% bodyfat, held this weight for 6 months so far so obviously no rebound.


Hello, your comment made me curious of these pills. I am currently 235 pounds and in desperate need to shed some weight. I am physically active but i need a booster to help me. So did you take the ephedra free pills (efx) or the regular? So you took them only for one week of every month? Did you have any side effects at all? I hope you have time to respond. Thks


Hello, your comment really made me curious of these pills. I am currently 235 pounds and desperately in need of shedding some pounds. I am physically active but need a boost in weight loss. Did you take the xenadrine epedra free or with it? Any side effects? So you only took them for one week of every month? I hope you have time to respond. Thks

  Hated the product.
Trever (Verified User)

took this stuff for 4 days and it felt like I was gonna have a heart attack it’s junk that could kill you

  Bring back the old Xendrian

Where you get the old Xendrian from cause i dnt want to waste my money on the new no good feed back

  Loved it but had side effects
Kelly (Verified User)

I absolutely LOVED Xenadrine. It seriously worked for me. I used it on & off for a couple years. I always kept the weight off. However, the physical toll it took on my health was irreparable. I started having seizures. It induced a seizure disorder in me that I have for the rest of my life now. Once I stopped taking it, the seizures completely stopped. However, I have to be on meds now to make sure they don’t come back. It’s SO disappointing. I loved Xenadrine, but it’s just not worth putting my body through hell. What’s even worse is now that I’m not taking it, my body doesn’t know how to work without it, so I’m working out & eating right..the same as I did when I was on it, & I’m actually gaining weight, & can’t keep it off. My body became dependent on Xenadrine, & now it’s impossible for me to lose weight. 🙁