Updated: 05/16/2017

Xenadrine Review - Does This Fat Burner Work?

  • 93 User Comments
  • Rating: 3.0. From 60 votes.
By Montana Rangel Apr 06, 2017

If you want the bottom line on Xenadrine, give me just two minutes of your time. We dove deep into the side effects, ingredients, customer service and scientific proof. Experiences from hundreds of users were part of the review. Finally, we condensed to give you the info you need.

Xenadrine Readers: Click here to find out why we're giving away samples of our product, Leptigen.

What is Xenadrine?

Firstly, Xenadrine is a fat burner with green coffee bean extract, garcinia fruit extract, caffeine anhydrous, raspberry ketone, frauenmantle leaf extract, wild olive leaf extract, cormino seed extract and horsemint leaf extract. Each bottle contains 120 capsules and you take up to six daily – two before each meal. The formula is supposed to help you lose seven times more weight.

Iovate Health Sciences is behind Xenadrine. The company started in 1995. It doesn’t look like the original formula is available on the official website, but you can buy it from outside retailers. We like the addition of caffeine and the price isn’t bad, but read on…

Results – “Mixed at Best?”

The first thing we felt needed to be addressed with Xenadrine ingredients was results. “We found dieters that did see changes and those that didn’t,” said our Research Editor. “If you’re researching before choosing a supplement that could affect your final decision.”

“My husband is…impressed with this product and swears that it’s helping him lose weight,” one buyer said.

A dieter also claimed, “Gives me that extra energy I’m looking for.”

Not all saw the benefit of Xenadrine fat burner.

“Not as good as the older stuff. Didn’t give me the energy I have come to expect,” one review explained.

Another user said, “Did not have any impact on weight loss at all.”

Xenadrine Side Effects – “Are You Feeling Off?”

Dieters have also reported some Xenadrine side effects across multiple reviews we read. Adverse reactions are not something anyone should settle for.

“Not really impressed with the product. It gave me jitters the first three days,” one buyer offered.

“I often felt very, very nauseated for an hour or two after taking Xenadrine,” as another put it.

There are also though who saw no side effects, though it may not have worked overall.

“It gives me tons of energy, no jitters,” claimed a customer.

One more said, “It provides energy, and has no harmful side effects, but that is all it is good for.”

We’ve found a strong connection between issues, like multiple poor reviews, and a smaller chance of lasting results. If Xenadrine does cause side effects or leaves the dieter wanting for more, they may switch it out for a supplement that’s clinically tested.

The Science – “Is It Proven?”

There’s some caffeine in Xenadrine, so that’s apt to boost energy. Two other ingredients, garcinia cambogia and raspberry ketones, are often considered more of a “fad” than anything else. There’s no conclusive research that shows they can effectively promote weight-loss in most dieters.

The Bottom Line – Does Xenadrine Work?

Did we rush out to pick up a bottle of Xenadrine? Well, we like that all ingredients are listed online and we believe the only side effects would be associated with the caffeine, but we are hesitant to give the thumbs up. The formula is not exactly as strong as it could be and dieters report side effects and lackluster results.

People who’re ready to lose that extra weight may want to leave Xenadrine behind to try out a clinically tested supplement with customer reviews that show nothing but positive results.

Among the best products we’ve seen this year is Leptigen. The label shows only four ingredients and all have been scientifically tested, according to the studies we found in peer-reviewed journals. Dieters talk about seeing fantastic weight-loss results in reviews across the web and side effects are minimal, at most.

Plus, Leptigen is available as a Special Trial Offer because the makers are so confident in the supplement.

Xenadrine Ingredients and Supplement Facts

Serving Size: 2 rapid-release capsules
Serving Per Container: 30
Amount per Serving % DV
Vitamin C 7 mg *
Calcium 70 mg *
Xenadrine Blend: 488 mg *
Extreme Energy and Metabolic Intensifier Complex * *
-Caffeine anhydrous * *
-L-theanine * *
-Yohimbe bark extract * *
-L-carnitine * *
-White willow bark extract * *
Powerful Weight Loss Complex: * *
-Frauenmantle leaf extract * *
-Wild olve leaf extract * *
-Cormino extract * *
-Homsesmind * *

Other Ingredients: Microcrystalline cellulose, gelatin capsule, tricalcium phosphate, dicalcium phosphate, magnesium stearate and silicon dioxide.

We dug deep into the Xenadrine ingredients to give you the details you need.

Raspberry Ketones

Raspberry ketones are the chemicals responsible for the smell of the fruit.

What is it Supposed to Do?

It’s supposed to promote weight-loss, even if you consume a high fat diet.

Clinical Research

A study published in a May 2005 issue of Life Sciences showed that raspberry ketones may help fatty liver in a high fat diet. “RK prevented the high-fat-diet-induced elevations in body weight and the weights of the liver and visceral adipose tissues (epididymal, retroperitoneal, and mesenteric). RK also decreased these weights and hepatic triacylglycerol content after they had been increased by a high-fat diet.”

If you’re looking for a weight-loss supplement, it’s important to find clinical research. You may want to consider Leptigen, which is formulated with scientifically tested ingredients.

Garcinia Fruit Extract

Garcinia fruit extract is an extract made from the garcinia cambogia fruit.

What is it Supposed to Do?

It is supposed to help control the appetite and prevent the body from storing fat.

Clinical Research

According to a study published in The Journal of the American Medical Association, “There were no significant differences in estimated percentage of body fat mass loss between treatment groups, and the fraction of subject weight loss as fat was not influenced by treatment group.”

Wild Olive Leaf Extract

This is a supplement made from the leaves of the wild olive plant.

What is it Supposed to Do?

Its high antioxidant value is thought to have a number of health benefits, mainly influencing cell activity.

Clinical Research

According to a study published in the Journal of Nutritional Biochemistry, “This mitochondrial targeting property may provide a possible mechanism for the efficacy of the Mediterranean diet for lowering the risk of cardiovascular disease and also suggests that hydroxytrosol [olive extract] may be used as a therapeutic intervention for preventing type 2 diabetes and obesity.”

Green Coffee Bean Extract

Green coffee bean extract comes from coffee beans that haven’t been roasted, so they contain more of the chemicals known to provide the health benefits of coffee.

What is it Supposed to Do?

The chlorogenic acid is supposed to help promote weight-loss.

Caffeine Anhydrous

Caffeine Anhydrous is a dehydrated form of caffeine. Caffeine is found in tea and coffee, and added to many sodas and energy drinks.

What is it Supposed to Do?

Caffeine is supposed to increase mental alertness and may also boost the metabolism.

Frauenmantle Leaf Extract

Also known as lady’s mantle, this herb grows in England. The extract is used in supplements.

What is it Supposed to Do?

It is used to treat stomach issues such as mild diarrhea and water retention.

Cormino Seed Extract

This comes from cumin, which is a seed that’s commonly ground and used as a spice in cooking.

What is it Supposed to Do?

It is supposed to aid in digestion and issues associated with the digestive tract. It is also supposed to help with hemorrhoids. Early research shows it may be helpful for diabetes.

Horsemint Leaf Extract

Horsemint leaf extract comes from the horsemint plant. Its leaves are used to make medicine.

What is it Supposed to Do?

It’s used as a stimulant, but can also be used to treat digestive problems like gas, and to make menstrual periods less painful.

Is There Anything Out There That TRULY Works?

There’s one supplement that fits the bill. Those who are interested can take advantage of Leptigen’s Special Trial Offer, direct from the manufacturer. Click here to give it a shot.

Xenadrine Questions & Answers:

We read through hundreds of user comments about Xenadrine to create this useful FAQ.

What are the side effects of Xenadrine?

Xenadrine side effects may include nausea, irritability, anxiety, upset stomach and headache.

What are the ingredients in Xenadrine?

Xenadrine ingredients are green coffee bean extract, garcinia fruit extract, caffeine anhydrous, raspberry ketone, frauenmantle leaf extract, wild olive leaf extract, cormino seed extract and horsemint leaf extract.

Does Xenadrine work?

There are studies listed on the Xenedrine website showing some users did notice weight-loss. What we found was the research centered on a small portion of the dieting population and tested focused on one ingredient, not the entire formula.

If you want to lose those extra pounds, think about what Xenedrine offers and consider switching it out with a supplement like Leptigen. The supplement contains some clinically-tested ingredients and has been shown to accelerate metabolism and ignite fat loss.

How much does Xenadrine cost?

Xenedrine costs $17.07 through third-party retailers. The supplement isn’t available on the official website.

How should I take Xenadrine?

You should take two Xenedrine capsules per day. Each bottle contains 120 pills, lasting 60 days.

Can I take Xenadrine if I have a health condition?

Those with health conditions, anyone under 18 years of age, women who are pregnant or nursing or people taking prescription medications should contact a healthcare professional prior to using any weight-loss supplement, including Xenedrine.

What do users like about Xenadrine?

Users liked that Xenedrine increased energy and the low price.

What do users NOT like about Xenadrine?

Users did not like the side effects they experienced while using Xenedrine.

How do I contact the Xenadrine customer service department?

You can contact the Xenadrine customer service department by calling 1-888-334-4448, emailing info@iovate.com or by sending letters to Iovate Health Sciences 381 North Service Road West Oakville, ON Canada L6M 0H4.

Can I snack between meals while using Xenedrine?

While you can snack between meals while taking Xenedrine, it’s not recommended.

How long can I use Xenedrine?

It’s recommended to use Xenedrine for only 60 days before taking a break.

Does Xenadrine come with a guarantee?

No, Xenedrine doesn’t come with a guarantee, considering it’s not sold on the official website.

Do you know of any special deals or discounts on Xenadrine?

There are no deals or discounts on Xenadrine. However, the last few months our readers have been focusing on losing weight, so they’re taking advantage of Leptigen’s Special Trial Offer, which is merely the cost of shipping and handling. Click here to give it a try.

Previous Xenadrine Review (Updated August 20, 2008):

Xenadrine: What You Should Know

Xenadrine, or Xenadrine EFX is a weight loss supplement that is developed and manufactured by Cytodyne. While this diet drug is available online, the official Cytodyne website is claimed to be "coming soon." Xenadrine EFX claims to aid in the weight loss process by helping with fat reduction and controlling weight. This diet supplement is available in some general nutrition stores. While the older version of Xenadrine contained Ephedra, the latest version of this diet supplement is stated to be Ephedra-free. Xenadrine EFX sells for $39.95 for 120 capsules.

Like many other dietary supplements, Xenadrine EFX is directed to be taken daily before breakfast, with water, two capsules at a time. Xenadrine EFX is supposed to be a part of a regular fitness regimen and a healthy diet plan in order to be truly effective. Some of the primary active components found in Xenadrine EFX are Vitamin B6 (10 mg), Proprietary Thermodyne Complex (1415 mg), Vitamin C (100 mg), Pantothenic acid (12 mg), Norambrolide (20 mg) and Magnesium (10 mg). Those that take Xenadrine EFX are supposed to be 18 years of age or older. There are some restrictions for Xenadrine EFX that include people with allergies to Tyramine, heart disease, hyperthyroidism, asthma, migraine headaches, renal disease, allergies to chocolate or those afflicted with high blood pressure.

List of Ingredients in Xenadrine

Tyroplex, Green Tea Extract, Vitamim C, Vitamin B6, Norambrolide, caffeine and polyphenols, Seropro (proprietary cocoa extract standardized for PEA [phenylethylamine], tyramine and theobromine), Magnesium, Yerba Mate (standardized for caffeine and methylxanthines), Guarana (standardized for theophyline), Calcium Tribasic, Pantothenic acid, dl-Methionine, L-Theanine, Ginger Root, Proprietary Thermodyne Complex, Isotherm (proprietary blend of 3,3',4',5-7 pentahydroxyflavone and 3, 3',4',7-tetrahyroxyflavone), DMAE, Grape Seed Extract, Talc, Magnesium Stearate and Gelatin.

Product Features

Xenadrine EFX is a dietary supplement that aims to assist both men and women with weight loss. This diet product is marketed in capsule form online and in stores. A healthy diet plan and regular exercise are recommended with Xenadrine EFX. Key active ingredients found in this product are Vitamin B6, Proprietary Thermodyne Complex, Vitamin C, Pantothenic acid, Norambrolide and Magnesium. Xenadrine EFX sells for $39.95 (120 capsules) and 2 capsules should be taken each morning prior to eating breakfast.

Advantages of Xenadrine

  • Xenadrine EFX is now available in an Ephedra-free form.
  • Xenadrine EFX comes in an easy-to-take capsule form.
  • Xenadrine EFX can be easily and conveniently purchased online.

Disadvantages of Xenadrine

  • The official website for Xenadrine EFX (Cytodyne) is not up and running.
  • Xenadrine EFX appears to documented real clinical proof regarding its effectiveness.
  • Xenadrine EFX does not appear to be offered with a 100% money-back/satisfaction guarantee.
  • Xenadrine EFX is clearly not suited for all individuals, due to the number of serious health warnings.
  • There is no free trial sample of Xenadrine EFX offered.
  • There do not appear to be any customer testimonials available.
  • May cause stomach irritation. (See reader comments.)


Like many other diet supplements currently gracing the market, Xenadrine EFX makes a lot of promises. Unfortunately it may be difficult for some dieters to decide on this particular supplement because of the lack of clinical research offered online. Furthermore, Xenadrine EFX would likely get more attention if the official company website was functional, offered some customer testimonials, free trial samples or a 100% money-back/satisfaction guarantee. Since Xenadrine EFX does come with some warnings, it's wise to consult a doctor before taking this diet drug.

Get Your Sample Today »
Dietspotlight Author
About the Author:

Montana Rangel holds both Associate of Arts and Associate of Science degrees. She is currently completing her Bachelor of Science degree in Public Health. For the past three years, she’s dedicated her time to researching whole foods, healthy nutrition, and healthy lifestyle choices. full bio

Rating: 3.0. From 60 votes.
Please wait...
Xenadrine Review

How Does Xenadrine Compare?

User Comments

93 Comments on "Xenadrine Review"

idk about this

ive been doing this for like a week and i have seen no difference): but ill keep trying i guss..


how many pills do i take a day ????? im on my 4th day help


if u r on 4th day u take 2 pils 15 min before each meal from then on…states on the bottle 🙂


can i take xenadrine while on a low carb diet such as atkins i am on my first two weeks { induction }

Can work

I took this product 6 years ago when it first came out along with a low carb diet. With a daily 30m-1 hr work, I lost 40lbs in 3 months and kept it off.


ummm so im 16…i took this pill 3times today 30minutes before each meal…will anything happen to me??? it also says dong take 5hours before bedtime..if u do take it will anything happen…i think ima stop takin it…

Hi Nikki! For detailed product and usage instructions, please refer to the Xenadrine official website for more information.


I just started yesterday. I pray it works.


Thinking about trying but have a couple questions first, please help! I have a seizure disorder but am on medication so i never have any seizures while on my meds. Also, i have had my gallbladder removed. Would it be safe for me to take this? I also have no time at all to exercise. So will this still help me lose weight or would it be a waste of money in my case? Thank you!!!

Hello Jen. All users are different and can experience different side effects; please make sure to consult with your physician before taking this product to make sure it is safe for you.

Lamar Matava

Wow! This could be one particular of the most useful blogs We’ve ever arrive across on this subject. Actually Wonderful. I’m also a specialist in this topic so I can understand your hard work.

Johnnie Jones

Nice product.


I’ve used this 1 TIME!! And I was way to jittery I couldn’t feel my heart beat, when I stood up I couldn’t feel my legs. I felt sick to my stomach. And i haven’t been able to sleep. I constantly feel like I have to throw up. This was recommended by a friend. I got the xenadrine ultra weight loss and I’m not happy. I’ve lost weight ya but I felt miserable the whole time I was on this product.. I don’t recommend this at all!


Never gonna take this again.


I will never use this product or any diet pill again. I had increased blood pressure, anxiety, depression. I made the mistake of drinking alcohol with them one time and it made matters extremely worse. If you can lose weight by eating right and exercise, do it that way.


I started taking this almost a week ago. The first day I took one pill and did some sit ups. Well my lower abdomen started hurting. I thought it was just because of the sit ups. Having one maybe two days of the abdomen hurting from sit ups is what usually happens it does not take a week for the pain to subside. I need to find a diet pill that is not so full of caffeine. I didn’t feel well and my insomnia has gotten worse. I am not happy with this product.


Made me way too jittery. Have been taking for 30 days and I am just not satisfied with the results. They offer a 100% money back guarantee but no way to contact them on the bottle or the website to get your money back?!?!?!

Stephen (Editor)

Hey, Sharon, try calling 1-888-334-4448 or emailing info@iovate.com.

Randyall ellingsworth

Didn’t work at all for me called u guys gave all info on bottle would like to have my money back thank u very much…

Victoria (Editor)

Hi Randyall. Please make sure to refer to the official Xenadrine website to contact their customer service department in regards to your refund.


I’m not really happy with Xenadrine at all..I’m trying to find how you can be refunded your money that you paid for them but have yet to come up with it any place. Could anybody help me with this please? I know I’ve been having trouble with my stomach since I started taking them but I won’t say it’s because of them but I didn’t have it before. I wish the best to everybody!!

Stephen (Editor)

Donna, try calling 1-888-334-4448 or emailing info@iovate.com.


Is xenadrine halal or haram
What is the source of gelatin
Is it from plants or animals

Val Helmus

Greetings. Awesome piece. we completely concur. You have got produced heaps of good points. Have actually a fantastic day.


I have been taking this for 10 days now. I started like it said with one pill before each meal then on the 4th day to take 2 before each meal. I loved the energy but now its day 10 and I am having kidney pain really bad. I drink plenty of water and I don’t know what’s going on. I think I will be stopping these pills which is unfortunate. I am going to try some lemon water and if it doesn’t go away by tomorrow I am not going to take anymore. I have been seeing a difference in weight loss however I have been on a strict diet I mean very strict and I have done this before and gotten the same results. I do not believe this really helps you lose any fat faster than if you dieted properly alone.


I’ve been taking it a week now watching insanity work out on YouTube also doing it with the sexy man trainin. I do step ups and bring my son and dog for walks. This gives me extra energy in the day time abs majorly curves my appetite. I’ve noticed a rash on the back of my leg and I stay up at night. When I can’t sleep I get up and exercise though. So win win tire murals out gotta to burn off that extra energy.


Hi DJ, where did you buy it from. I thought Xenadrine EFX was no longer on the market. I’m looking for it. Thanks


I am at the week mark and ive lost 5 of the 40 lbs i need to lose. It does make me a little jittery but i just go like mad, workin out 4 days a week and walking a little the other 3 days. I hope this can get me goin, gotta lose some weight for my wedding. 5’5″ 190.


I am on my first day of this product. I have drank a lot of water and I have been peeing like crazy. Will update in a week