Updated: 09/22/2015 - Sponsored by Leptigen

PolyGlycoPlex Review - Does This Fiber Supplement System Work? Are lack of results and harmful side effects deal breakers?

Editor's Review: 3.5 / 5.0

polyglycoplex-product-imagePolyglycoplex is a product that’s been around for a long time and has grown in popularity. We decided to review Polyglycoplex because many people have not heard of it, but it has generated a lot of interest lately as a fiber supplement and weight loss tool. We looked at online reviews, side effects, ingredients, scientific research and clinical data to provide a summarize review for our readers.

EDITOR'S TIP: Combine PolyGlycoPlex with a proven fat burner such as Leptigen for better results.

What You Need to Know

Polyglycoplex is a fiber supplement that supposedly boosts weight loss results by blocking sugar and suppressing appetite. The ingredients include some well-researched ingredients like Konjac Root Extract and Glucomannan, as well as leaf extract, gelatin, water, rice powder, magnesium stearate, and more. The product is to be taken once a day with a glass of water, and is convenient enough for those with a busy lifestyle to take on the go.

These fiber supplements have been on the market since the late 2000s. It’s still relatively new to the diet industry, but it’s readily available online and easy to find. Polyglycoplex is affordable, easy to take, and seems to have some positive comments online, but read on…

Lack of Results – Disappointing weight loss claims

The weight loss claims made by Polyglycoplex seem too good to be true, and in many cases they are. “Polyglycoplex blocks sugars in addition to suppressing your appetite with fiber,” said our research editor. “Because of this, this product will not work for many people.” Many people have seen results, but many medications, disorders or diseases, or personal lifestyles can conflict with this product, making it difficult to achieve the weight loss claims.

“These are affordable, but I didn’t lose any weight. These pills don’t make me feel full, so I’m still hungry after taking them,” said one user.

“This product had no effect on me; I won’t buy again,” said another. This stuff might work wonders, but who can afford it?,” said another.

Scroll below for one of the best products we’ve seen in 2015.

Negative Side Effects – Another Concern

Another issue we had with Polyglycoplex was the high frequency of negative side effects. There are many significant side effects for those on high blood pressure medication, those with diabetes or hypoglycemia, and those on cardiovascular or mood altering drugs. Some of these side effects can include thoughts of suicide, unstable blood sugar, palpitations, or decreased mood. Many other customers also reported less severe side effects including stomach cramps, headaches, diarrhea, and more. “I took Polyglycoplex last night, and can’t make it out of the bathroom long enough to do anything today,” said one customer.

“This interfered with my current medication and could have caused dangerous side effects if I didn’t catch it right away,” said another. Many users agreed and had to stop taking this supplement prematurely. “I saw a decreased appetite with Polyglycoplex, but I also had cramps and headaches,” said another customer.

Our research has shown that whenever there is something that is abnormally difficult or troublesome about a diet or exercise program (cost, taste, negative side effects, painful workouts, etc.) the likelihood of sustained weight loss is decreased. If Polyglycoplex really does have a long list of negative side effects, this could make it difficult to lose weight and keep it off.

The Science

One good thing about Polyglycoplex is that it does have some clinical research proving its effectiveness, but some of the research was done on lab rats, and the results may not be the same for human consumption. There are also no studies that explicitly state that Polyglycoplex is fit for human consumption without severe side effects. At DietSpotlight, we value scientific research and published data, so when a company is missing this research, or it has incomplete research, we see major cause for concern.

The Bottom Line

We like that Polyglycoplex is convenient, easy to take, and affordable, but we can’t recommend it as a safe, effective weight loss product for our customers. The lack of published data on humans is discouraging, and the fact that they tested this on lab rats instead of humans is alarming. The side effects that many customers have seen concern us, and there may be some long term issues caused by this as well. We’re also concerned that the results that the product claims don’t work for many customers.

If you’d like to drop some weight without the side effects, we suggest you find a supplement that provides healthy weight loss with proven ingredients: a product with scientific research and published studies on human subjects that confirm that it is safe for human consumption and effective at helping customers lose weight.

Leptigen is one of our staff’s favorite products so far in 2015. The proprietary blend of just four ingredients has not been linked to negative side effects in online reviews, and their claims are backed up by double-blind clinical studies that have been published in peer-reviewed journals. These studies also show the effectiveness of this product to help users lose weight by accelerating fat loss and boosting their metabolism. Leptigen also has great customer feedback online from customers that have been able to lose weight without negative side effects.

Right now, the makers of Leptigen are showing just how confident they are that you’ll love their product and see results that they’re offering a special trial offer.

Learn More About Leptigen »

(Feel free to scroll below for our previously published full-length PolyGlycoPlex Review)

Previous PolyGlycoPlex Review (Updated May 21, 2014):

What You Should Know

Click Here To See Our Highest Rated Review

PolyGlycoPlex is marketed as a sugar blocker and a proprietary soluble fiber complex that will provide users with glucose management. It also states that it can suppress the appetite. This product also claims that, when taken correctly, it can regulate bowel movements. This PolyGlycoPlex seems to be targeted at men and women equally, but it seems to be targeted at those who are over forty years of age more than it is younger adults. Users are instructed to take this product with a full glass of water before meals for best results. It is not stated how much of this product should be taken and the maximum daily allowance is not posted.

This products website also hosts a variety of other products so it is can be a bit difficult to find PolyGlycoPlex. The website does not offer much information on this product and there are no user testimonials posted for it. Those wishing to use PolyGlycoPlex can do so without a prescription because it is considered a dietary supplement.

List of Ingredients

Konjac Root Extract (amorphophallus konjac k. koch), Sodium Alginate, Xanthan Gum, Mulberry (morus alba), Glucomannan, Powdered Extract (leaf), Gelatin, Purified Water, Rice Powder and Magnesium Stearate (vegetable grade).

Product Features

PolyGlycoPlex contains Mulberry which is supposed to have antioxidant qualities as well as prevent insulin and glucose meals from rising after meals. The ingredient Xanthan Gum is supposed to be beneficial to the digestive tract. The ingredient Glucomannan is supposed to help suppress the appetite, lower cholesterol and lower the glycemic index.

See Our Featured Diet


  • PolyGlycoPlex contains a large amount of fiber and that can be healthy.
  • This product does not contain any laxatives or stimulants.


  • It can be harmful to block sugars and starches.
  • Blocking carbohydrates may not be safe or desirable for everyone.
  • PolyGlycoPlex does not contain any proven fat burners or appetite suppressants.
  • Those taking MAOI's, SSRI's, antidepressants, NSAIDS, corticosteroids or certain other medications should not take this product.
  • Those who have diabetes, hypoglycemia, high blood pressure, cardiovascular ailments or certain other medical conditions should not take PolyGlycoPlex.
  • Women who are pregnant or nursing should not take this product.
  • Glucomannan may inhibit the absorption of certain essential nutrients.
  • There are no user testimonials posted for PolyGlycoPlex.


PolyGlycoPlex does not really stand out from the rest of the supposed glucose managing and appetite suppressing fiber based weight loss supplements available today. PolyGlycoPlex may not be an effective weight loss supplement because there does not seem to be any proven appetite suppressants or fat burners in it so those seeking a weight loss supplement with the ability to suppress the appetite and burn fat may want to research other products that are intended for appetite suppression and fat burning. Those seeking weight loss may also benefit from developing a healthy diet and exercise program that suits them and their lifestyle. Users will need to assess their health and fitness goals and decide if using PolyGlycoPlex is right for them.

GD Star Rating

6 User Reviews About PolyGlycoPlex

Leave comments below
  • 1

    this product is not for everyone. I have had the shakes for 3 days after i started taking these, and I can’t leave home for other reasons if you get my drift… I am currently taking depakote and lamictal for GAD, and wouldn’t recommend it for anyone with mood issues without talking to your doctor first!!!


  • 2

    Amazon.com = PGX (Natural Factors PGX Daily Ultra Matrix Softgels 750 Mg, 240 Softgels). Comes in packets or pills. $41.70


  • 3
    Mary Ann Soltis

    Where can I buy polyglycoplex


    Linda Lucchesi

    I purchased the Hi Health version, called PGX supreme, this had no seaweed or Japanese root, I was not pleased with this product


  • 4

    Can you send me info on the Free Trial? And do you have any testamonials? How much do you charge for the product?



    I just posted this reply on the website, but wanted to let you know that the polyglycoplex, along with coQ10 has significantly reduced my appetite and my craving for sugars and other carbs. I’ve lost 8 pounds in the past three weeks (I follow the weight watchers diet plan, which I was doing for several months before but still had cravings and always felt hungry!)I am happy with the results simply because it has helped with the cravings and hunger. It may be a placebo effect, but whatever it is, it is working very well for me! Just wanted to share. Thanks,


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