Updated: 02/02/2016 - Sponsored by Leptigen

Cholestoff Review - Does This Cholesterol Supplement System Work? Are lack of results and harmful side effects deal breakers?

Editor's Review: 2.9 / 5.0

cholestoff-product-imageCholestoff is made by Nature Made, one of the leading vitamin manufacturers in North America, which prompted us to look into this product as a weight loss solution. We looked at the ingredients, side effects, and clinical research as well as the company behind this product. We also read user reviews and complaints online to learn more about this product. Once we gathered all this information, we summarized and condensed what we found to allow our readers to make a decision for themselves.

EDITOR'S TIP: Substitute Cholestoff with a proven fat burner such as Leptigen for better results.

What You Need to Know

Cholestoff comes in a bottle that contains anywhere from 50 to 500 capsules depending on where you buy it and what size you buy. The capsules contain silicon dioxide, magnesium stearate, titanium dioxide, calcium, plant sterols, and stanols from pine trees. These ingredients are designed to help lower bad cholesterol and improve overall health.

As noted above, Nature Made makes this product, and they’re well-known in the vitamin industry, which is encouraging. Cholestoff is easy to find in drugstores, health and fitness stores, grocery stores, and online, and the capsules are easy to take and affordable, but read on…

Lack of Results–No Weight Loss Benefits

We were immediately disappointed with Cholestoff when we found that it is completely ineffective as a weight loss supplement. “Cholestoff has been linked to reduced cholesterol, but it has no known weight loss benefits,” said our research editor. “So if you’re looking to lose weight, this product probably isn’t the best way to reach your goals.”

“I saw minor improvement in my bad cholesterol, but I didn’t lose any weight,” said one user.

“No weight loss at all, extremely disappointed,” said another.

Scroll below for one of the best products we’ve seen over the last year.

Negative Side Effects–Minor, or too much to Overlook?

Several reviewers online and a few medical professionals mentioned links between Cholestoff and harmful side effects, which is another reason to be concerned about this product. Minor gastrointestinal issues like diarrhea, stomach pain, heartburn, and indigestion are common, but more serious issues like ulcers and dehydration may occur in some individuals. “With Cholestoff, I’ve been having joint pain and discomfort,” said one customer.

“This stuff has led to constipation for me; I won’t buy again,” said another. Unfortunately, there were a few people that saw more serious side effects: “When taking Cholestoff, I had difficulty breathing and would often wake up out of a dead sleep with shortness of breath.”

With diet supplements like Cholestoff, we’ve discovered that when a particular part of a diet program is particularly difficult (painful workout routine, bad taste, harmful side effects, etc.), the likelihood of long-term weight loss success is slim. If Cholestoff really does have these negative side effects for some customers, it could make it difficult for dieters to meet their weight loss goals.

The Science–Is Cholestoff an Effective Weight Loss Supplement?

We were initially encouraged by the science behind Cholestoff. A recent study shows that this product can reduce cholesterol levels by as much as 5% more than a placebo. While this is far from the 15-25% that some dieters claim, the fact that it’s backed up by research is encouraging. Unfortunately, when it comes to weight loss, there doesn’t seem to be any benefit to taking Cholestoff. Without science proving that a product is effective for weight loss, we’re skeptical and have a hard time recommending it as a weight loss product. While this may be good for those looking to reduce their bad cholesterol and get their overall cholesterol levels under control, it doesn’t seem to have much benefit for those looking to lose weight.

The Bottom Line–Is It Worth It?

We like the research behind Cholestoff’s cholesterol reducing claims, the affordability of this product at just $7-15 per bottle, and the availability of this product in stores around the country; however, we were left disappointed with the lack of evidence supporting Cholestoff as a weight loss product. We’re also concerned about the harmful side effects, the lack of weight loss results, and the mixed reviews online.

If you’re looking for a better alternative to meet your weight loss goals, go with a supplement that provides more bang for your buck and scientific evidence that proves it is an effective weight loss solution.

Among the best products we’ve seen in 2015 is one called Leptigen. With a proprietary blend of four ingredients, Leptigen offers proven weight loss results and has scientific results backing its claims. The four ingredients are specifically formulated to help burn fat and boost metabolism, which has been confirmed by published studies. We’ve read hundreds of user reviews and comments about Leptigen, and most people seem to see great results without harmful side effects.

Also, Leptigen is currently part of a special trial offer, which is a sign that the company believes in its product.

Learn More About Leptigen »
GD Star Rating

How Does Cholestoff Compare?

Previous Cholestoff Review (Updated September 20, 2014):

What You Should Know

Click Here To See Our Highest Rated Review

Cholestoff, manufactured by Nature Made, is a product that claims to naturally help to lower the cholesterol for those that high levels of it. This product is said to contain ingredients that have been well known to lower the cholesterol naturally in the body and these ingredients reportedly prevent the body from absorbing any further dietary cholesterol.

According the statements on the Cholestoff site, the natural supplement can help to reduce the cholesterol by up to 24% and also reportedly helps to improve the overall health of the heart as well.

List of ingredients

Cholestoff contains quite a range of ingredients and among these are: plant sterols or stanols from pine trees, Tribasic Calcium Phosphate, Croscarmellose Sodium, Hydroxypropyl Methylcellulose, Calcium Carbonate, Silicon Dioxide, Magnesium Stearate, Titanium Dioxide (artificial color), Polyethylene Glycol, Triethyl Citrate, Polysorbate 80 and Sodium Citrate.

Product Features

First of all, when looking at Cholestoff you should be made aware that the bottom of the site clearly states that the product is not meant to cure, treat, diagnose or prevent any disease which makes the viewer wonder if the product matches the hype that has been attached to it. Secondly, it also mentions that it has not in any way been evaluated by the Food and Drug Administration (FDA) which again leads to scepticism about the product.

Cholestoff is not suitable for pregnant women or women who are breastfeeding and also, despite the fact that it is a supplement, the user should consult with a medical professional such as their local doctor or physician before taking the product.

See Our Featured


  • Cholestoff uses plant derivatives as its active ingredients which are all natural.
  • Cholestoff is very inexpensive. One bottle of Cholestoff retails for about $7.


  • Cholestoff makes a lot of claims on the official website but has limited information backing them up.
  • For those with high cholesterol, you may want to rely on products a little more well known to avoid serious health issues.
  • Various reviews around the Internet vary greatly between "Doesn't work" and "Wonderful" so we can't get a good feel for the effectiveness of this product.
  • Cholestoff is ineffective as a weight loss supplement.


High cholesterol can lead to life-threatening conditions if left untreated for a long period of time. Cholestoff claims to help lower your cholesterol which could be very beneficial. This product is so inexpensive, we don't see how it could hurt to add it to your daily routine if you are concerned about your cholesterol levels but you may want to use it in addition to something recommended by your physician. We can't really categorize Cholestoff as a "weight loss" product so if you are looking for a way to lose weight, you should probably keep looking.

37 User Reviews About Cholestoff

Leave comments below
  • 1

    My particle cholesterol level went from 2847 to 2532 in 6 weeks. A little over a year it was 1450. My calculated cholesterol went from over 200 to 145. Those are two types of cholesterol tests. The particle is more accurate. Cholestoff works! The biggest diet change I made was decreasing my ice cream intake.


  • 2

    I took this product for a little over a year. My cholesterol went from 2832 to 1450. This is from a particle lipid test, not calculated. Most people have the calculated test, whereas your number should be below 200. A particle test is more accurate. You can have a normal calculated test, but particle shows the truth. Cholestoff works!


  • 3
    Jose Gonzalez

    I take Crestor and Metformin. Is CholestOff Plus safe to use with these medications?


  • 4

    How soon does Cholestoff starts working?


    Your Name

    I had a particle lipid test done. My cholesterol went from 2832 to 2547 in 6 weeks. A little over a year it went down to 1450.


  • 5

    It’s not cheap


    Edward Bond

    U are soooo correct


  • 6

    I have been taking Cholestoff for several weeks, and I developed heart palpitations during this time. Not sure if they’re connected. Has anyone else had this experience? Does Cholestoff contain anything that could be bad for the heart?



    I been taking Cholestoff for nearly a month and until i read that you were having palpations i couldnt figure out why my heart was beating differently almost like its racing i will stop taking cholestoff. Did your palpations stop after discontinuing it.


  • 7

    Does cholestoff turn your stool dark?


  • 8

    I just start taking CHOLESTOFF… hope it works for me… after taking Crestor for a long time I start having terrible muscles pain. I’ll post again in a couple of month and see if it owrks for me


  • 9
    debbie levesque

    i’m on 40mg of zocor, can i take cholest off with that.


  • 10

    I t works. In 6 months went from 220 to 181.


  • 11

    I would like to say this stuff really works!!! I dropped from a 163 to a 130 in 2 weeks, I promise!! I really believe I will be at good levels within 2 months


  • 12

    My moms cholesterol level went down 24 points on this, but while taking this with Red Rice Yeast she got really really ill and had to stop the Red rice yeast. I am taking Cholest off and have lost a few pounds already!


  • 13

    I have used Cholestoff w/ Red Yeast Rice for several years. My cholestrol level continues to come down. I have avoided taking prescription medication. High cholestorl runs in my family and I have wanted to avoid taking it. I am also a runner [I run every day] and a vegetarian!


  • 14

    I’ve had really good luck with Cholestoff lowering my cholesterol numbers, but I’m having a lot of bloating, gas, and loose stools. Lots of stress in life right now, so I’m not sure what is the culprit, but started taking Cholestoff about the time the stress began. Has anyone else had digestive issues along with Cholestoff?



    I had the same bloating thing at first, but it seems to have gone away. Maybe because I now make sure I take it before a meal (or just after).


  • 15

    Zocor has given me diabetes
    can I take cholestoff instead of zocor?



    zocor has given you diabetes???? are you positive???maybe I should stop taking zocor!!!



    alot of the prescription statins cause your blood sugars to go way up. Same thing happened to me, was put on meds for diabetes and test every day with my meter. Went of statins and guess what diabetes went away and metformin discontinued!!!!!! It is not an uncommon complication of statin drugs. I am going to try cholestoff instead….


  • 16

    As a nurse I was very skeptical to take supplements and statin. I came across Cholesteroloff at Costco and read the ingresients. I asked my doctor about it and we both decided to check my cholesterol level as the baseline reading.However, I was still skeptical and waited another month.Then I decided to take Cholesteroloff for 4-6 weeks and had my cholesterol level checked and to my surprise my cholesterol dropped to 193.I decided to continue taking it but will have frequent chemistry testing of my kidneys, liver and cholesterol or lipid profile.Furthermore,hyperlipidimia runs in my family.


  • 17

    I have been taking Cholestoff for months..after having horrible side effects from prescription statin meds. which did not work well. Cholestoff really worked for me! My doctor was so pleased with my blood test results and then I told her that I had been taking Cholestoff for the previous 6 months. (she had never heard of it!)


  • 18

    I take losartan and metoprolol er and have used cholest off for 4 months without side effects. I also started a low fat low cholesterol diet at the same time. My blood test showed a drop in total chol. from 235 to 193. If you’re interested in this product you can buy 240 caplets at amazon.com fo about $15 (about a 2 month supply) There are other supplements that are supposed to be much better, but they run about $35-$40 per month. With the cost so low, it’s at least worth a try.


  • 19
    Mary Puraty

    What are the adverse side


  • 20

    I take blood pressure medicine, is it okay to take cholestoff?


  • 21

    can you take cholet off & fish oil together



    Yes you can my dr recommended me taking the two together


  • 22

    With no diet modification my cholesterol has remained as with meds. I’m going to change my diet to try and reduce it further. At least I have no muscle pain w/ Cholestoff. Muscle pain is a major side effect of Simvastatin.


  • 23

    my cholesterol is a little high if i start taking cholestoff vitaman do you think it will help lower it


    Your Name



  • 24

    can i take this my blood presure meds


    rosie montoya

    Can we take highblood presure medication


  • 25




    Can I take Cholestoff with Zetia(not a statin, but and alternative prescription) I can’t take statins as they caused side effects.



    I’ve been told, by my cardiologist, that Zetia has been linked to, possibly, causing cancer. Check it out with your doctor before taking it.
    I began taking CholestOff just less than a week ago. I’m a severe diabetic and, all of a sudden, my blood sugars are thru the roof…..tonight, 3-1/2 hrs after supper: 406. I’ve also felt slightly off balance as well. I don’t think CholestOff is for me. I’m discontinuing it.
    I, too, have tried statins. Atorvastatin gave me severe leg cramps; Crestor gave me diarrhea and with Livalo, after five weeks, I had unbearable hip(s) pain that spread to my lower back and went around to my abdomen and groin. So I don’t know what the answer is. Everything I’ve read on statins is negative.


  • 26
    Dennis Jones

    I would like to see scientific studies on Cholestoff. Otherwise, I do not take your commendable comments of Cholestoff seriously.


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