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Align Review - 16 Things You Need to Know

I need to confess: I was obsessed with researching Align. We conducted an in-depth review, closely investigating the ingredients, side effects, customer-service quality and clinical studies. Plus we analyzed hundreds of user reviews and comments from around the web. At last, we summarized and condensed the information we collected to give you the bottom line.

Align can be purchased through their Official Site.

Align Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Align?

Align Probiotic is a natural supplement designed to support digestive health as well as possibly promote weight loss. Naturally, the human digestive system contains good and not-so-good bacteria that mix, but the good ones keep the bad ones at bay. However, sometimes, there is a need for an external agent to overpower the maleficent bacteria when they start to outnumber the beneficial ones. Align is a probiotic which serves as a balancing agent in the gut so that issues like bloating and acid refluxes are not prevalent. These abnormalities in the gut system are because when varying diets, exercise routines, lifestyle changes, and stress collide into one’s life.

Align serves to keep a user going, eliminating the chances of an imbalance in the digestive system. Well, at least, that is the claim, but what does science say about probiotics and health.

  • Advances in Nutrition – “Probiotics are living microorganisms that confer health benefits to the host when administered in adequate amounts; however, dead bacteria and their components can also exhibit probiotic properties. Bifidobacterium and strains of lactic acid bacteria are the most widely used bacteria that exhibit probiotic properties and are included in many functional foods and dietary supplements.”
  • British Nutrition Foundation – “Probiotics have become a popular approach for managing digestive and immune health and are being recommended more frequently as effective therapeutic interventions by medical professionals.”
  • Journal of Food and Drug Analysis – Right now, one of the focuses of clinical research into probiotics is as an adjunct therapy, partnered with lifestyle changes, for weight loss.

Align Competitors

Other similar products: , 1MD Complete Probiotics Platinum, Peptiva

What Are Probiotics?

Probiotics are living microorganisms that are highly beneficial to the host’s health when they are taken in healthy doses. It can also be said to be introducing ‘good’ bacteria into a living body for beneficial purposes.

Just as antibiotics fight pathogenic or harmful bacteria in the body, probiotics bring in healthy bacteria into a system to replace the harmful ones, promoting good health and long life.


Benefits of Probiotics

align benefits

When the gut system of a person is unhealthy, it could lead to countless sicknesses. But when it is healthy, there are many benefits to be gained from it.

There is usually filtering of the digestive system of all things harmful, like toxins, chemicals, and waste products, when probiotics are introduced.

The maintenance of the gut barrier function and gastrointestinal motility is regulated correctly when there is a proper balance of healthy bacteria.

Remember that the human system is made of natural healthy bacteria that fight pathogenic bacteria when they come, which is inevitable because we eat and get stressed.

And do not forget that probiotics are live microorganisms (bacteria) that are healthy, according to NCCIH.

Probiotics also serve to fight off antibiotics-induced diarrhea, abdominal pain, infectious diarrhea, and bloating.

In addition to these, probiotics help with the immune system. The immune system is one of the most critical systems in the human body because it is the body’s protection. When it does not function fully, the body ultimately shuts down because it is thrown open to all manner risks.

If all the researchers are correct, then this is probably the most critical function of probiotics. According to Tropical Life Sciences Research, researchers in their preliminary stages have equally linked probiotics to a healthy oral cavity, skin, and lungs.

Probiotics Side Effects

Probiotics Side Effects

According to the Clinical and Translational Gastroenterology, the following list is a compilation of possible side effects that could be experienced by users of probiotics (Align is marketed as a probiotic):


This has been reported by some users of probiotics, even though it is a small percentage.

Such people have equally reported feeling nauseous, having diarrhea, and sweating more than usual. So this could be dependent on a body system.

Brain Fog

For intelligent and self-aware people who happen to use any probiotic, some fogginess is notable.

It appears as if bacteria in the digestive system can affect the generation of neuroactive molecules, which are theorized to have the ability to alter brain activities. This could be the cause of the fogginess.


This is one of the most typical side effects of taking probiotics, and this may come with some stomach ache caused by indigestion.

A possible cause for constipation may be that the harmful bacteria are replaced due to its good introduction.

Your body may take a little while to get used to this change; for some people, this change could stretch to several weeks.


Some people have reported experiencing cramping around the stomach and chest area as a result of taking probiotics.

For others, they experience aches all over the body when they start taking probiotics.


A small percentage of individuals experience fatigue when they start supplementing with probiotics.

This may be due to the body working extra hard to fight off the harmful bacteria when the good ones come into the system.

Company Info

How Did Align Probiotic Supplement Start?

There is no sensational story behind the genesis of Align. Just like every other invention, the need for a trustworthy probiotic has driven countless researchers in this area.

Align was developed by a team of gastroenterologists, with ten years of scientific research. The unique component of Align is Bifidobacterium Infantis 35624 (B. Infantis 35624).

This particular strain is similar to the good bacteria found naturally in the human digestive system; this aids in digestion while ensuring the host remains healthy. Other ingredients that contribute to the work of Align are:

  • Microcrystalline Cellulose
  • Hypromellose
  • Propyl Gallate
  • Magnesium Stearate
  • Sodium Caseinate
  • Trisodium Citrate Dihydrate

Align Ingredients

align ingredients

Bifidobacterium Infantis 35624

According to Reviews in Gastroenterological Disorders, Bifidobacterium Infantis 35624 (B. Infantis 35624) is a patented probiotic strain that is well-known for its unique ability to aid digestion and reduce intestinal inflammation.

It has also been proven to be safe and without an increase in the negative effects which are already there.

Therefore, B. infantis 35624 is a special kind of live strain of bacteria, unique in its delivery. It takes care of digestive and intestinal abnormalities; the human gut contains beneficial and non-beneficial microorganisms (bacteria, to be precise) but B. infantis serves to add strength to the good bacteria which would in turn help with digestion.

Recent reports show that the beneficial properties of probiotic strains are dependent on the types of strains, themselves.

According to Microbiology Letters, the possible probiotic advantages “can only be attributed to the strain or strains tested, and not to the species or the whole group of lactic acid bacteria or other probiotics.”

Microcrystalline Cellulose

Microcrystalline cellulose is a name for refined wood pulp that can be used for a number of things, including an anti-caking agent, an emulsifier, and a fat substitute.

A fat substitute is a type of food that acts like fat, with the same functions, chemical and physical characteristics, and stability of normal, everyday fat but with fewer calories per gram.

This ingredient serves to help eliminate fat by replacing it with a fat substitute so that your body would still have fat to work with but with less of the danger that comes with regular fat.


Hypromellose is short for hydroxypropyl methylcellulose and is a partly synthetic, inert polymer which can be used as eye drops or an excipient in oral medications.

An excipient is a bulking agent, used as a backup for more active ingredients in drugs whose amounts are too small. It can also help drug absorption and solubility. It serves to help the supplement dissolve in your system in order to work faster.

Propyl Gallate

This is an ester formed from ethanol and gallic acid. It acts as an anti-oxidant, which serves to eliminate the effect of oxidation in the system.

Oxidation produces free radicals which lead to chain reactions that may damage cells in the human body. It has beneficial health effects. The introduction of this into the system has advantages that cannot be overlooked.

Magnesium Stearate

Magnesium Stearate is a compound made up of two stearic acids and magnesium.

It also works as an excipient, meaning that it enhances the therapeutic effects of the most active ingredient(s) in the drug, as well as aiding the swallowing of drugs and its easy movement down the intestinal tract.

Sodium Caseinate

It is a complex name for casein, a type of protein found in the milk of mammals. It represents 80% of the protein in cow milk and 60% of the protein in human milk.

Trisodium Citrate Dihydrate

This can be used to resist changes in the pH levels as an acidity regulator or a buffering agent. It can also be used as a preservative, flavor, or food additive.


Does Align Work?

The patented B. Infantis 35624 strain is a proven effective microorganism. According to Clinical Gastroenterology and Hepatology, because of this, it is believed that any probiotic which contains it is excellent and reliable.

From the dozens of reviews from customers from various locations all over the United States, there is a rave about it; the positive acclaim is glaring.

In addition to this, Align is gluten-free so that there is no barrier for possible users, just in the event a gluten-sensitive person decides to try it.

Would we recommend it based on these? Probably, but considering that there is never a 100% efficacy to anything so bear that in mind.

However, from this standpoint, it would not be unsafe to refer someone to it.

Align is available on the official website or Amazon for approximately $21 for 28 capsules.


How to Use Align

Align contains a live bacterium, the B. infantis 35624. If you are already taking an antibiotic and require a probiotic, give a few hours before and after the antibiotic because it may get in the way of the probiotic working well.

Please don’t take it for more than two days; visit your doctor. Don’t be your own doctor.


Align Results

Yes, you probably have some other probiotic which you use but are not entirely comfortable with.

So why should you try this? What makes it stand out from the rest? There is nothing better than the public, different people, with different perceptions and orientations, saying practically the same thing about something.

Do not get it wrong; we are not putting our money where our mouth is on this yet, but the claims are notable. Some of the results which users claim to have got from Align are:

  • Restoration of stomach balance
  • Quick action, giving fast relief and response
  • Total reliability
  • Affordable
  • Works better on the stomach than dairy products
  • Can be preserved at room temperature, unlike many others that need refrigeration
  • Takes care of flatulence

Know that in almost everything, the good comes with the bad. Hardly anything is 100% fool-proof but sometimes, the good trumps the bad.

Align Side Effects

Align Side Effects

There are several wrong turns which may occur from the continuous use of the supplement.

Align is a probiotic. Therefore, any negative or adverse effect generally associated with probiotics could be equally associated with the supplement.

The side effects listed are from the few users who had not-so-good reactions to the supplement. These include:

  • High fever
  • Bloating
  • Cough
  • Rash
  • Swelling of the throat and tongue

Like we have said before, you cannot have it all. Just know how your body works and go with the flow.

One thing to be aware of is that it contains milk, making it an allergy concern for lactose intolerant ones.

If it doesn’t work, don’t force it. There are other side effects, so if you notice any adverse change in your system while taking it, you know what to do.


Align Claims

Align has claims to be different from other probiotics because it has the patented B. infantis 35624 strain, even though there are no clinical proofs yet to back up its claim of being beneficial to digestive health.

Furthermore, it claims to be the top choice of probiotics brands that are recommended by gastroenterologists in the United States for as long as nine years.

Weight Loss

Align and Weight Loss

Align does not blatantly claim to be a fat burner. Two groups of good micro bacteria are found in the digestive system: firmicutes and bacteroidetes.

Bodyweight is dependent on which of these two groups of bacteria is more in a person’s system.

If a person has more of the firmicutes, then such a person tends to be overweight, and if a person has more of the bacteroidetes, then such a person has an average weight.

With the balancing ability of probiotics, Align can help a user shed extra fat by creating a workable balance between the firmicutes and the bacteroidetes.

Should you trust it to lose weight? Not entirely. No particular supplement, no matter the reviews, works without proper exercise and dieting. So, don’t put all your ‘weight’ on one tiny capsule.


Align Lawsuits

According to Law360, there have been lawsuits connected to Align probiotics. The case, detailed at AlignSettlement.com, agreed to pay up to $49.26 to people who purchased the supplement between March 1, 2009, and June 6, 2016. The lawsuit pertained to advertising and marketing.

Align Alternatives

Just in case you find yourself too comfortable with this probiotic, as funny as that sounds, you could try Culturelle.

It is an equally good one with a different strain called Lactobacillus Rhamnosus GG, the number one selling probiotic strand in the United States.

According to Drugs.com, filed for a patent in April of 1985 by Sherwood Gorbach and Barry Goldin, Lactobacillus Rhamnosus GG was isolated in 1983 from the digestive tract of a healthy person, meaning that it is a good bacterium and advantageous to the digestive system.

The claim is that the strain is bile-and acid-stable, generates lactic acid, and is likely in the human intestinal mucosal cells.

This strain is the world’s most studied probiotic strain, with over 800 studies to its name.

The patented B. Infantis 35624 strain is a proven effective microorganism. According to Clinical Gastroenterology and Hepatology, because of this, it is believed that any probiotic which contains it is excellent and reliable.

From the dozens of reviews from customers from various locations all over the United States, there is a rave about it; the positive acclaim is glaring.

In addition to this, Align is gluten-free so that there is no barrier for possible users, just in the event a gluten-sensitive person decides to try it.

Would we recommend it based on these? Probably, but considering that there is never a 100% efficacy to anything so bear that in mind.

However, from this standpoint, it would not be unsafe to refer someone to it.

Align is not available on their website but you can use the buy now option to find a store near you. Amazon is frequently listed as an option.

What Users Are Saying

What Users Are Saying

“Probiotic these were recommended by my gastroenterologist. They do the job great!”

“Didn’t reduce gas in my stomach – It didn’t do what it was supposed to. Their were no side affects. Just didn’t work for my problem.”

“I have not noticed a difference in gut health. I will try the product for one more month and see if there is a notable benefit.”

Bottom Line

The Bottom Line on Align

Still, considering Align for weight-loss? Well, we like that it promotes digestive health and that we found some positive user reviews, but we’re skeptical about this one because there’s no direct connection between the formula and weight-loss. We’re also concerned because customers are talking about negative side effects and how they’re not seeing results.

Losing weight is a journey that you don’t have to travel alone. So, we suggest going with a program that promotes weight loss with a support system to see you through the tough times and successes.

Among the best programs we’ve seen this year is one called Noom. The weight-loss app is centered around personalized solutions, like human coaching and customized meal plans – but it’s much more than that. Expert articles, food tracking, exercise tracking and more are included with the app.

The makers of Noom are offering customers a free trial offer; this is an exceptional sign of confidence in their weight-loss app.

Learn More About Noom »
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What is Align?

Align is a daily probiotic supplement.

What are the side effects of Align?

Some of the common reported side effects of Align include bloating, thirst, and constipation.

What is in Align probiotic?

The ingredients in Align include bifidobacterium infantis 35624, microcrystalline cellulose, hypromellose, sucrose, magnesium stearate, sodium caseinate, titanium dioxide, trisodium citrate dihydrate, propyl gallate and gellan gum.

Does Align work?

While there’s research supporting the active ingredients in Align as it relates to improving digestive function, we didn’t find science proving it’ll work for weight-loss.

A healthy digestive system is essential to losing weight, so you should consider combining Align with a supplement like Dietspotlight Burn, which contains some clinically-tested ingredients and has been shown to accelerate metabolism and ignite fat loss.

How much does Align cost?

The cost of Align ranges from $18.99 for 14 capsules to $59.99 for 56 pills. One bottle lasts between 14 and 56 days.

Where can I buy Align?

Align can be purchased using their Official Site.

When should you take Align?

You should take one Align capsule per day at the same time.

Is Align a laxative?

No, Align isn’t a laxative. The supplement supports a healthy digestive system. Align contains probiotics, which can cause bloating, abdominal discomfort, and gas. Probiotics are normally associated with prevention of diarrhea.

What are the benefits of Align probiotic?

Align will improve digestion in many people, including: bowel problems, vaginal yeast infections, urinary tract infections, eczema, and lactose intolerance.

Is Align gluten free?

Align is gluten free, vegan, non-GMO, and dairy-free probiotic supplement. Gas or bloating could be a side effect of its use for the first few weeks.

Is Align probiotic over the counter?

Yes, you do not need a prescription for Align Probiotics.

15 Align Reviews

  • Anonymous

    Align will disrupt your hormone balance, damage your connective tissue, lower your collagen and cause cellulite. Yes it makes you gain weight.

    • Anon above is a liar

      hahaha, prove it. Been taking it per dr’s prescription for years. Cured diverticulitis and actually helped me lose 23 pounds. Have zero cellulite. Why? because I actually do something other than sitting all day long and watch what i eat. You sound like a scorned lover

    • Anonymous

      i been using align for three years and I keep losing weight.

  • Does Alvin make you use washroom alot?
    Tonya (Verified Purchase)

    Does Alvin make you use the washroom a lot? Cause I go at least 5 times a day and is it healthy for me to be going like that?

    • Maribel (Editor)

      Hello Tonya. All users are different and can experience different side effects; please make sure to consult with your physician before taking this product.

  • I've become very itchy all over, can this be a side effect?
    helen grant (Verified Purchase)

    I recently started taking align as per my gi doctor, I have noticed since taking it ive become very itchy all over, can this be a side effect?

    • Maribel (Editor)

      Hi Helen. The side effects that we’ve come across are bloating and gas, we haven’t come across itchiness. However, all users may experience different side-effects. Perhaps, it might be a good idea to check another product? With Dietspotlight Burn users reported positive reviews with no serious reported side-effects.

      • joanne

        i also am itchy all over and have been taking this product for about 4 months now

  • Can align raise my cholesterol?

    Can align raise my cholesterol

    • Maribel (Editor)

      Hello Suzi. All users are different and can experience different side effects; please make sure to consult with your physician before taking this product.

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