Updated: 12/07/2017

We hear a lot of buzz about AMPK activation, the new technology from LA-3. We wanted to learn more, so our attention turned toward the ingredients, side effects, and clinical research. Additionally, we read through hundreds of user experiences and testimonials. Then, we summarized the details to give you the info you need.

LA-3 Readers: Click here to find out why we're giving away samples of our product, Burn HD.

What is LA-3?

LA-3 is a supplement that is manufactured by LA-3 Live Cell Research, which is based in California. The company refers to itself as a “nutraceutical” company because it focuses on producing nutrition-based supplements that help heal and repair the body so that it can function at its best.

But this is not a real title since the FDA does not review the use or efficacy of most natural products that are sold over-the-counter at stores or on the internet. And there is still little crossover between pharmaceutical-based drugs and plant-based nutritional supplements.

LA-3 is sold either separately or in an LA-3 kit. The LA-3 kit contains other health products that are supposed to rejuvenate a person’s body on a cellular level.

Many health supplement watch groups have been keeping a close eye on the products sold by Live Cell Research because they have seen numerous complaints regarding unhappy customers who spent a fortune on LA-3 products, but didn’t get any of the results that they were promised. [1]

Products Similar to LA-3

Royal Slimread
AMPK Activatorread
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Burn HD (Sample offer)read

LA-3 Ingredients

What most people find reassuring about purchasing products from the Live Cell Research company is that this supplement manufacturer is very careful to avoid adding in any potential allergens as LA-3 ingredients. None of them contain any lactose, animal products, or chemical-based preservatives.

They are also very open about the list of ingredients that they use. This particular product only contains three LA-3 ingredients, which are:

  • Gynostemma pentaphyllum leaf extract (450mg) [2]
  • Quercetin dihydrate (100mg) [3]
  • Berberine HCI (100mg) [4]
LA-3 Customer Testimonials

What Does the LA-3 AMPK Activator do for a Person’s Health?

The three active ingredients in LA-3 are supposed to work together to act as an AMPK activator. The activator is a product that increases the production of the enzyme adenosine monophosphate-activated protein kinase in the body, which is depleted as part of the natural aging process that people go through.

Supposedly, this enzyme holds the key to everlasting youthful energy. So by increasing the amount of AMPK that a person has in their body, they can feel like their old self again. [5]

Does LA-3 Work as Well as the Company Promises it Does?

Unfortunately, there has not been any reliable research done to determine if LA-3 does work or not. So the only way to know what it does is to look at studies completed on each of its active ingredients.

Gynostemma Pentaphyllum

The first ingredient, gynostemma pentaphyllum, is also called “jiaogulan.” It comes from a plant that flourishes in the wild in China, so it is often used in the traditional medicine there. [6]

People in this region of the world seem to live for an exceptionally long time. And some believe that this is due to the way that they drink a tea made with jiaogulan on a near-daily basis.

This longevity and the search for another plant-based sweetener led to rumors being spread of the plant being a “fountain of youth” that could extend a person’s life to over a century.

This information was never proven. Still, jiaogulan is currently used, in alternative medicine, to treat just about every ailment that a person can think of, such as cancer, immune system problems, and liver disease. [7]

Quercetin Dihydrate

The quercetin dihydrate in the LA-3 pills is different. It was studied more intensively in many small clinical trials. But most of them were sponsored by companies that manufactured quercetin dihydrate supplements. [8]

What researchers found is that quercetin dihydrate is an insoluble chemical in fruits and vegetables that may have antioxidant-like properties. But that doesn’t mean that it is a miracle cure for any disease.

Not long ago, the FDA sent out warning letters to companies who sold quercetin dihydrate products because they were making claims that it could treat serious illnesses, such as cancer. Since this isn’t true, the companies had to change the wording of their advertising for the product to reflect a more accurate statement about it.

While quercetin dihydrate acts similar to an antioxidant, it doesn’t have the same chemical composition as one. So it doesn’t have the same ability to cause damaged cells in the body to self-destruct the way that antioxidants can. [9]


The last ingredient, berberine, has gotten the most attention because it has been proven by some small research studies to reduce inflammation and high blood sugar more efficiently than many pharmaceutical products can.

Berberine is also plant-based. Among others, it can be found in barberry, goldenseal, and Oregon grape plants. [10]

What are the Benefits of LA-3?

Live Cell Research says that there are many LA-3 benefits that come with taking their product. Just a few of the LA-3 benefits include:

Improved Energy

Supposedly, when a person can build up the amount of AMPK they have in their body, they begin to have the energy they once did when they were younger. In fact, this benefit is one of the supplement’s biggest selling points since many adults over 40 years old suffer from fatigue from leading a hectic lifestyle.

Improved Cognitive Functioning

When a person’s body can’t use energy properly, it can cause them to have “brain fog,” which impairs their memory and ability to concentrate. LA-3 is supposed to be able to help improve the insulin response of the body, so the cells are no longer starved for sugar. Live Cell Research says that this alone improves a person’s forgetfulness and ability to perform tasks that require a high level of reasoning skills. [11]

What are the Side Effects of LA-3?

Fortunately, LA-3 isn’t a supplement that has a lot of dangerous side effects. In fact, there have only been a few LA-3 side effects reported.

Though extremely rare, when some people first starts taking LA-3, they sometimes get:

  • Stomach pain
  • Diarrhea
  • Nausea

These symptoms are not supposed to last very long, but eating before taking LA-3 doesn’t reduce them either. Most people who have experienced these issues say that this only lasts about a week or so.

It is also possible for a person to develop low blood sugar because of the berberine that is in the LA-3. This usually poses no problem for a person with normal blood sugar levels, but those who have blood sugar that is in the low to normal range could experience a sudden drop that could be dangerous to their health. [12]

Is LA-3 Safe for Everyone?

LA-3 pills are generally safe for adults who are not pregnant or planning to become pregnant. They shouldn’t be used by women who are nursing because the ingredients could be passed on through the breast milk to the baby. Children shouldn’t take it at all because there have not been any studies done to reflect its safety for them.

Is LA-3 Expensive?

When researching where to buy LA-3, those who are interested in this product won’t have to pay too high of a price.

Live Cell Research recommends people start out with a 90-day supply of their product, which is three bottles. But it is also available in individual 30-day bottles too. The cost of each bottle is about $60.

There is also a 90-day guarantee available on all of the LA-3 products. So if a person doesn’t get the results that they were hoping for, they can return the product for a full refund. However, some consumers had made mention of the poor customer service available when they tried to get their money back.

LA-3 Results

There have been mixed experiences regarding LA-3 results. Some say that they were able to lose a little weight, but not as much as Live Cell Research claimed that they would. Others mentioned that it never improved the brain fog that they were suffering from.

To combat the negative issues, Live Cell Research explains how the LA-3 fat burner works – in stages.

  • During the first week of taking it, a person is supposed to have more energy than they have ever had in years.
  • After two weeks of LA-3, the cravings for unhealthy foods are gone, and their thinking will be improved.
  • And after one month’s time, there should be a noticeable difference in someone’s weight.

LA-3 Scam?

There could be problems with the way Live Cell Research seems to target older Americans who are desperate to improve their health and regain their youth. However, this targeted marketing is common among longevity-supporting supplements.

Also: read our Burn HD Weight-Loss Kit review »LA-3 Ingredients

The Bottom Line on LA-3

Will LA-3 be the key to activating your longevity? Well, based on review and research, there’s a chance that you’ll notice results. There’s solid science supporting the claims. As with any supplement, results vary. But, with this one, it’s apparent that users see positive changes. You want to lose weight and improve overall health.

Why not consider going with a supplement containing a formula supported by positive customer reviews.

Among the best supplements we’ve seen this year is the product Dietspotlight Burn. It contains four clinically-tested ingredients with supportive results published in peer-reviewed journals showing improved metabolism, decreased weight and increased fat loss. Users all over the web report amazing results.

The Dietspotlight Burn company stands behind the product, and they’re so confident that they’re offering a Special Trial Offer.

Learn More About Burn HD »
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What are the side effects of LA 3?

LA 3 or LA-3 side effects, reported by customers, may include a mild headache.

What are the ingredients in LA-3?

LA-3 ingredients are gynostemma pentaphyllum leaf extract , quercetin dihydrate , and berberine hcl .

How do I know if LA-3 is right for me?

Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients.

Click here to get your sample of our powerful fat burner today.

What is the active ingredient in LA3?

The active ingredient in LA3 is Gynostemma pentaphyllum leaf extract.

Does LA-3 work?

There are studies showing that the ingredients in LA-3 may be effective in enhancing mental clarity and focus. There are reports showing it also helps reduce stress.

How should I take LA 3?

It is recommended that you take two capsules per day with a glass of water.

Does LA-3 contain stimulants?

There are no stimulants in LA-3.

How much does LA-3 cost?

A one-month supply of LA-3 costs $46.99.

If you are looking for a product that offers a trial option, you might want to check out Dietspotlight Burn.

LA-3 Ingredients

LA3 is all about getting that energy going and helping you live longer.

LA-3 Ingredients and Supplement Facts

Serving Size: 2 Capsules
Serving Per Container: 30
Amount per Serving% DV
Gynostemma Pentaphyllum Leaf Extract450mg*
Quercetin Dihydrate100mg*
Berberine HCL100mg*

Other Ingredients: None

  • References
  • 1. (). . .
  • 2. (). . .
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.

63 LA-3 Reviews

  • How long it to be used?

    How long do I need to use this product, is that a lifetime thing or it has a time limit?

    • Montana (Editor)

      Hello Elana! We don’t believe supplements, of any kind from any company, are intended to be used for a lifetime. It does get a little confusing, however, when you’re talking about longevity.

      The research we found says none of the three ingredients – berberine, gymnostemma and quercetin – should be taken for longer than three months.


    I have a problem with large amount of caffeine, I get heart palpitation, does this product have caffeine or energy booster?

    • Montana (Editor)

      Hi Graciela! There is no caffeine or stimulants in LA-3. However, since you tend to get heart palpations with ease, please make sure you consult with your doctor if you happen to experience any reactions to the ingredients. Wish you the best of luck!

  • Can I use it with other products?

    I am taking Truvision diet pills which curve my appetite. I want to start taking the LA 3. Does anyone know if I can take them together or not?

    • Victoria (Editor)

      Hi! Because these products are from two different companies, we don’t want to say yes or no. If you look at just the ingredients, we can’t find research saying there would be a negative interaction, however please double-check with your physician.

      An alternative to Truvision that you might want to look into is Dietspotlight Burn. Customers are raving about their results.

  • What are the instructions?
    Deanie Browning Holland

    I have a question, I have ordered this for my son. I would like to know when is the best time to take (Am vs Pm)? and if taking with or without food?

    • Anna (Editor)

      Hey Deanie. The directions say to take two capsules by mouth with water. No time of day is mentioned and you can take them with or without food.

  • Mary

    Is this product good for women over 50’s that are going through menopause and hot flashes? Not that has any relations but, I’m afraid to get more hormonal side effects, please help

    • Anna (Editor)

      Hi Mary! If it helps, there are no hormones in LA-3. The issues with menopause that you’re feeling are from a drop in hormones.

  • What part of the body does it target?

    Does this help with Visceral Fat?

    • Anna (Editor)

      Hi Greg! Supplements cannot target a certain area. Unfortunately, your body will lose weight from the area it wants to lose weight from. As you lose weight, you lose visceral fat. Also, the product is supposed to helps fight fat in the abdominal region through a process called AMPK activation. AMPK is an enzyme that tells the body to stop storing fat. Hope this helps 🙂

  • Side effects question
    Diana Carballo

    Has anyone experienced an increase in heart rate? faster?

    • Anna (Editor)

      Hello Diana. We have heard for a few users here and there that they felt some jitters or fluttering after taking LA-3. These reviews are rare, but they are out there.

    • Monica

      No increase in heart rate. I actually don’t feel an increase in energy what I experience is endurance. If I work out I feel like I don’t want to stop. I also noticed the same when I’m cleaning, it keeps me going where I would normally stop. Hope that helps.

      • Anna winter

        I concur with the above statement.

  • Carlos Singletary

    I smoke can i use la3?

    • Summer (Editor)

      Carlos, we haven’t heard of any problems with smoking. However, please consult with your physician to make sure it’s safe.

  • Should I increase dosage?
    Edie (Verified User)

    I’ve been taking LA3 for 4 months now. In the beginning I could see the difference in the appetite surpression and energy increase, but this has subsided. Should I increase my dosage ? If so, by how much and when.

    • Maribel (Editor)

      Hi Eddie, please continue with the dosage as instructed. Have your eating or exercise habits changed since you started the product?

      You might want to look into other appetite suppressant products if LA 3 is no longer working for you. For appetite suppression, we recommend Dietspotlight Burn.

  • Is it available in Europe?

    Is LA-3 available in Europe?

    • Montana (Editor)

      Hi Zlatko! All LA-3 shipments are made through the United States Postal Service. There’s no mention of international shipping.

  •  Buyer Beware
    RDT (Verified User)

    I purchased a 3-month supply of LA-3, and after using for 30 days, have not noticed any of the glowing rewards attributed by other consumers. The only noticeable difference I’ve found is a slimmer wallet.

  • Can't find this product
    Ebenezer kwarkye

    I am Ebenezer in Ghana West Africa. How do I purchase LA 3?

    • Victoria (Editor)

      It looks like LA-3 is only shipped to addresses in the United States.

      • Diana Qualls

        I love my la3 for the first time in my life I have a normal bowel movement every morning I can look down and see my belly button and for me that’s an accomplishment

  • Twana

    I watched the video on fb & it states they are not promoting this for weight loss, but as a deep fat reducer. Now, it might just me, but if you reduce the deep fat, which is supposed to be the cause of people getting fat, then if you reduce this deep fat, then you should lose weight… it’s just my thoughts.

    • Elias Samaha

      I’m not actually over weight but I have a fatty liver

      Juts my 2 cents worth

      I’m not in this for the weight loss just the fat around my organs

      • Cathi Paradysz

        LA-3 is a great product my first month I lost 6 lbs 3″ in waist 2″ in hips It’s now been 9 weeks on it I lost 18lbs
        5″ in waist & 4 inches in my hips. I heading to be a diabetic AC1 was 6.8 now 6.2 Sugar was 148 now 112.
        By my next blood test I will be back in order on my AC and sugar this is a life saver for me. Plus I haven’t even exercised that show how good this LA-3 is helping your blood levels and your organ. Those who said it
        doesn’t work must not be taking it at the same time everyday. I had just order another 6 bottles I can’t say enough about this LA-3 product. Like the other people had said it’s not a diet pill it’s helping get rid of the fat cell that have built up on your fat cell. If it’s not working for you what did you lose nothing money back guaranteed most products don’t even guaranteed your shipping back.
        For the people that it is working for stay with it you will have a healthier body in the long run.

        Cathi Paradysz

        • lisa

          Can you buy this La 3 at GNC or just the net and how much money are we talking for bottle or three month supply? Thanks

          • Richard (Editor)

            Hi Lisa. It appears as if LA-3 isn’t available on the GNC website, but Live Cell Research does sell the supplement. One bottle costs $46.99 and a three-month supply costs $117.

        • Victor Cabatuan

          Hi Cathy, My bodies response to LA-3 is very much similar toy yours….. I have just completed my 1st 30 days of use and I have more energy and have lost 8 lbs and have lost 2 inches off my waist line….. It has also reduced my hunger pangs and I am eating less. So I have to believe this product is working for me. Berberine I understand will help me with my blood sugar and cholesterol issues. My blood pressure is almost perfect every day when checked…..

      • Glynis

        Have you see a difference in your liver labs since taking lA3? I have a fatty liver too and am hoping for positive results.

  •  Over a year now, no lifestyle changes, not losing but not gaining weight either.
    Patrick Leonard (Verified User)

    I have been using LA-3 for over a year now, and am trying to provide a review that is honest and not based on post-purchase rationalization to influence my comments. What I can say is that I have done nothing to change my eating (average to poor) and exercise (little to no) habits, and my weight has stayed within the same 5 pound range over that time (I weigh myself at least once a week). That includes through the holidays. Blood work has been the same too, with just slight drops in cholesterol and triglyceride levels. I suspect I would see more improvement if I can resolve issues with sleep apnea since that has a huge negative impact on all three of the conditions that AMPK is supposed to help with (metabolic response , mental acuity and energy levels). My energy levels and mental sharpness are hard to judge in comparison, but I would say my focus has gotten a little better over time (subjective measure). It would also help if I improved my diet and exercise routine, but I have inadvertantly been performing a controlled test with the only change being the addition of LA-3 AMPK supplement.
    I do believe if I am able to reduce/eliminate sleep apnea that that alone would also improve all three. I wouldn’t say LA-3 has provided drastic results for me, but I don’t expect drastic, I expect small incremental improvements, and I know that many people respond differently to different supplements based on genetics, diet, exercise habits, consistency in use, and so on. Don’t go out there looking for a fountain of youth pill….you won’t find it, but maybe something that slows the process ever so slightly? I’ll take that! If I could give this 3.5 stars I would, because I think it deserves more than 3 stars, but 4 might be too much of a recommendation of the product. Temper expectations.

  • Doesn't work for me
    Rebekah (Verified User)

    I’m half way done with my first bottle. I have gained weight. I do not have more engery or clearer mind.

    • Mary

      Give it some time ! When I first started this product I was under stress and for the first 2 months I saw very little change. I started taking a extra pill at 3 pm. I have lost inches. And 7 lbs… also I have l a few lipoma they are shrinking. Been 3 months now feeling pretty good.

  • I take medications..

    Was wondering if LA3 works well with someone that has cholesterol, thyroids problems high blood pressure and diabetes 2 , also taking meds for the heart?

    • Victoria (Editor)

      Hi Angela! Nearly all supplements companies that we’ve encountered have included warnings about health conditions on their label. When we looked at some products from Live Cell Research, the company that makes LA-3, we didn’t see a warning.

      That said, it sounds like you have a number of medical issues that you’re likely being treated for. Interactions between supplements and medications are possible, so check it out with your doctor first.

  • We'll see what happens
    Tereasa Heilman (Verified User)

    I’m on day 3. I have no intention of changing anything in my daily activities. It either work’s or it doesnt. Not everyone’s body is influenced positively upon taking the same product so i hope it helps me.

  • Not sure yet
    Kim (Verified User)

    I will start on day 8 tomorrow. Can’t say if it’s working or benefiting just yet. However, I plan to start an exercise to routine to loose my belly fat

  • My experience..

    When I started taking LA-3 I did feel energy.

  • Katherine

    Grate fresh ginger root and steep it like tea. Strain and drink the liquid. Works miracles for Type 2 diabetes. Check your blood sugar before doing this because there days I don’t have to take meds. My A1C 9. I’m below 5 now and on my way down to normal

    • Patrice

      I haven’t really followed this thread but am curious if the ginger root tea is in addition to the LA-3?

    • Tom K

      How often are you drinking the ginger, 1 or 2 times daily, weekly ?



  • MissKitty

    The minute I started using LA-3 I noticed a drastic change in my energy level, that was 2 days ago when I received my 3 bottles. Personally I’m impressed, I got on the scale this morning and I had lost 5 lbs in just 2 days, unheard of for me as I am almost 66 years old and have no trouble gaining wait but loseing it is much harder. I’ve gotten more inspired to do the projects that have sat for months even years. Honestly I think how this stuff works is individual and it is working for me!!

    • Charity

      Does it cause loose stools?

      • Summer (Editor)

        Hi Charity. Your body reacts to the ingredients in LA-3 differently than other bodies. Talk of loose stools is not common, but there is a possibility it could happen – as is the case with any supplement.

  • Lisa D.

    The instructions clearly say to take two capsules with a glass a water first thing upon rising in the morning. I’ve been consistent in doing this, and have had phenomenal success in gaining energy and losing inches (and my ‘love handles’), and I’ve only been taking it for three weeks.

    • Helen

      Day 2 and my energy levels are up , had breakfast although not really hungry but am dieting also ,so we will see what happens

  • PhyllisJH

    I was concerned about the weight loss because I am a petite person and not wanting to lose weight with the exception of the abdominal and waist budge. I am experiencing the loss in appetite. I have to make myself eat to not lose weight. The abdominal budge has not gone down as I would like. I have taken 1 bottle and I am on my 2 one. I am happy with the boost in my energy level. If I don’t see the budges dwindle by the time I finish the 2nd bottle, I won’t invest in this product again. There are some pluses and some negatives.

    • Karen

      I feel the same way! The 1st bottle I had more energy, lost 8lbs and was feeling good about this product.

    • LBS

      This has been the same results for me. I concur on the pros and cons.

  • Lisa

    Just started my first dose yesterday. I almost immediately noticed an increase in energy. I’ve been battling a cold and after taking LA-3 I was able to get up and function. I am excited to see what the results will be.

  • Sheryl

    Just started this and will try for 3 months. I don’t remember anything being said about being a weight loss product. It claims to revitalize aging cells.

    • Summer (Editor)

      Live Cell Research claims LA-3 can help with weight loss. According to the product description, “less fatigue, fewer cravings, more energy and a slimmer waistline.”

  • Jo Cook

    As far as I understood it from the video on facebook they’re not promoting LA-3 for weight loss it’s more to help your organs be more healthy that are covered in deep fat and helps reduce said fat which in turn will have health benefits and an added benefit could be weight loss but ultimately your organs will be a lot healthier which would help reduce the possibility of all sorts of health related issues. You’re giving the impression it’s soley for weight loss which as far as I understand it from the video is totally not the case.

  • Belly Button...
    Gloria Britt (Verified User)

    On Day 15 and began feeling a sensation around my belly button. It’ is not pain, no nausea, but just a “sensation”.have not lost any weight yet it’s the same. Anyone else experience this sensation?

  •  A Definite for LA3
    Anna winter (Verified User)

    I am quite pleased with the LA3. I wasn’t expecting a wonder drug an I am someone that takes a wait and see with any product. Part way through the first month, I realized that mid-morning I wasn’t starting to droop or lose energy. This is important for me as I work outside eight hours a day. I am on month 4 an I will be continuing to use this supplement. The benefits I am experiencing with this supplement is worth the cost to me. I also compare the product to another S rather expensive supplement that I have been using an I will not be re-ordering the other one.

  •  No apparent benefit.
    Larry Sprague (Verified User)

    I have been using this product for over 60 days along with dieting and exercise. I do not see any extra benefit with taking the LA-3. Any weght loss I have seen is consistent with the diet and exercise program I am on. I was looking to see a noticeable difference by using LA-3, but there was none.

  • Frances Bravo (Verified User)

    Can I take LA3 and Forskolin together?

  •  How long does this take to begin working?
    Violetturtle (Verified User)

    I’ve been using this for about 2 weeks now and I have not experienced any of the three beneficial effects that are stated on the website: no clarity, no energy boost – less in fact, no decrease in appetite and…I’ve gained 2 pounds. 🙁 I have not changed anything and I’m not eating more. I’m hoping something changes. Otherwise, this is not for me.

    • Victoria (Editor)

      Hello! We’re sorry that you weren’t able to achieve the results you wanted with LA-3. Have you looked into other products? You should check out Burn HD!