Updated: 11/24/2015 - Sponsored by Leptigen

Prevagen Review - Does This Memory Supplement Really Work? Are adverse effects and user complaints deal breakers?

Editor's Review: 3.2 / 5.0

PrevagenYou may be surprised by what I say in this Prevagen review. We at DietSpotlight dug deep and thoroughly researched this product’s ingredients, side effects, customer-service quality and scientific studies. Plus we took a close look at hundreds of user reviews and customer comments from around the web. At this point we compressed all the facts to give you the important info you need.

EDITOR'S TIP: Combine Prevagen with a proven fat burner such as Leptigen for better results.

What You Need To Know

Prevagen is an over-the-counter supplement that is claimed to improve your memory. This product can be taken once each morning, and it’s claimed to support a healthier brain, clearer thinking and a sharper mind. Prevagen is geared toward men and women who are ages 40 and up. According to Quincy Bioscience, the company that makes this product, people begin to require “more cognitive support” after the age of 40. Prevagen is available in regular strength, extra strength and chewables. Depending on where you buy this product, it costs $40 to $60 per bottle (30 capsules). The primary ingredient found in Prevagen is Apoaequorin (10mg).

Prevagen has been available since at least 2012 and it can be purchased via Amazon. This supplement is available in common drugstores such as Walgreens and CVS Pharmacy, and a helpful FAQ section is provided on the company website, but read on…

Adverse Effects – A Consideration?

“There are numerous complaints of adverse effects from Prevagen. Some users have complained of side effects such as high blood pressure, fast heartbeat, fainting, chest pains, dizziness, headache and tremors. Also, Prevagen was under the investigation of the FDA back in 2012, which is concerning,” says our Research Editor.

One user complained, “Developed heart flutter about 75 days after I started taking this. Do your research on this product! Do not recommend, better forgetful than dead.”

“Upon taking my first Prevagen, within a half hour I became light headed and dizzy and my focus was worse than ever the rest of the day,” commented one user. Another person said, “I don’t have high blood pressure and it made my blood pressure go sky high. DO NOT BUY.”

Scroll below for one of the best products we’ve seen in 2015.

User Complaints – Another Concern

Numerous customer complaints are posted online concerning Prevagen. One user stated, “I had a reversal of memory while taking this product. Many instances where I forgot peoples’ names in public situations.”

Another customer said, “I took the Prevagen 10mg pills for 30 days and I honestly don’t notice any difference. Don’t waste your money on this.”

The extensive research we’ve done has revealed if there is a particular facet of a dietary supplement that is very bothersome or concerning (adverse effects, high cost, too many user complaints) the probability of long-term success is low. In other words, if Prevagen does cause adverse effects in numerous users and leads to a lot of customer complaints, this could be a serious problem.

The Science – Is it Legit?

There are some studies presented on the official website that pertain to the key ingredient in Prevagen, which is Apoaequorin. While this is good to see, there was also an FDA investigation into Prevagen, because of this key ingredient. The FDA had to issue a warning about this product because it can lead to serious side effects, which is a major red flag.

The Bottom Line: Does Prevagen Work?

So, should you buy Prevagen? Well, we like that Prevagen is easy to find in common drugstores and we did see some positive comments about it online. However, we are concerned about the FDA warning and the overall safety of this diet supplement. Furthermore, we have some issues with the numerous customer complaints posted online and the adverse effects Prevagen can cause.

If you’d like to shed more pounds of fat, we encourage you to go with a product that is not only backed by clinical research, but is also safe to take daily, does not cause adverse effects and is not tainted by an FDA warning.

Among the best products we’ve seen in 2015 is one called Leptigen. This supplement uses four unique ingredients, which have been proven in documented clinical research to help boost metabolism and speed up fat loss. We have not found any talk of negative side effects and user comments posted online indicate people are seeing substantial results.

The makers of Leptigen are so confident in their product they’re offering a Special Trial Offer, which is a good sign.

Learn More About Leptigen »
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How Does Prevagen Compare?

Previous Prevagen Review (Updated June 16, 2014):

What You Should Know

Click Here To See Our Highest Rated Review

The brain protects its cells from degradation by generating a protein that regulates cellular calcium. If calcium increases in cells, they will be destroyed. With the natural aging process, the body generates that protein in lesser amounts. Prevagen is a supplement that promotes the better health of the brain and its functions. The product focuses on improving memory loss and protecting the brain by supplying it with a protein called apoaequorin. This protein belongs to a family of molecules that binds calcium. Prevagen can easily be bought from health food stores as well Rite Aid stores. However, the website’s online shopping page allows interested clientele to purchase the amount they want.

List of Ingredients

The only ingredient that is mentioned on the website is the apoaequorin protein, which is extracted from jellyfish. Even the concentration of that protein isn’t mentioned in the Prevagen material.

Product Features

Prevagen claims to bind calcium in cells, thus reducing the damage which occurs when the body doesn’t produce many calcium binding proteins as it ages. The apoaequorin protein, which was discovered in the early sixties, is apparently responsible for the whole calcium binding process. The research conducted by the supplement’s developers supposedly demonstrated that the apoaequorin protein mainly benefits consumers by enhancing their mental clarity, honing their decision-making skills, improving their memory and helping them focus. However, these claims haven’t been confirmed by the FDA. Still, the website promises consumers positive results between periods of use from 30 and 90 days.Aside from that, the product has been approved to be kosher by two of the four main production facilities in the United States.

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  • The website does offer supporting evidence regarding Prevagen’s effects on memory and sleep.
  • An informative video explains how the supplements will enhance the brain’s functionalities.
  • The website directly states that it hasn’t been FDA approved, thus spares consumers the time and effort of trying to locate the FDA approval stamp.


  • The product isn’t FDA approved. Although the website was truthful enough to mention this fact, it still isn’t a favorable factor.
  • There are no indications regarding Prevagen being free from side effects.
  • The supporting studies were limited studies, not full-scale ones.
  • The evidence supporting the product is mainly anecdotal and not quantitative.


Age does affect the body in various ways, and the brain is no exception. If Prevagen is really as good as it claims to be, people will really benefit immensely. However, with the supplement’s shortcomings, caution should be taken prior to its consumption.

Prevagen FAQ:

We summarized hundreds of user comments about Prevagen into this helpful FAQ.

What are the side effects of Prevagen?

Some potential side effects of Prevagen include heart arrhythmia, fainting, tremors and chest pains.

What are the ingredients in Prevagen?

The ingredients in Prevagen are apoaequorin, white rice flour, sodium chloride, magnesium stearate and acetic acid.

Does Prevagen work?

There’s no scientific research proving Prevagen is effective, although the website claims there’s proof. You may want to consider mixing things up a bit and changing out Prevagen with Leptigen, which contains ingredients clinically proven to work.

How much does Prevagen cost?

Prevagen costs $59.95. If you buy two bottles, the price increases to $119.90. Three runs $239.80 and eight costs $479.60. You receive a discount on multiple bottle purchases.

How should I take Prevagen?

You take Prevagen once in the morning with or without food. One bottle lasts 30 days.

Can I take Prevagen if I have a health condition?

Woman who are pregnant or nursing, anyone taking prescription medications, people with health conditions or anyone under 18 years of age should consult a healthcare provider prior to using any supplement, including Prevagen.

What do users like about Prevagen?

Some users like the affordability of Prevagen and that they receive a discount on multiple bottle purchases.

What do users NOT like about Prevagen?

We found that some Prevagen users don’t like the side effects associated with the supplement. Additional concerns included ineffectiveness and difficulty reaching the customer service department.

How do I contact the Prevagen customer service department?

You can contact the Prevagen customer service department by mailing correspondence to Quincy Bioscience 301 S. Westfield Rd. Madison, WI 53717, emailing a representative at customerservice@prevagen.com or calling 1- 855-331-7721.

What is the main ingredient in Prevagen?

The main ingredient in Prevagen is apoaequorin. This is found in certain species of jellyfish.

Do I have to diet and exercise on Prevagen?

No, you don’t have to diet or exercise on Prevagen, but the company recommends adding healthy eating and fitness to any supplementation.

Can I purchase Prevagen at local stores?

Yes, you can purchase Prevagen at local retailers. You may not receive the multiple bottle discounts.

Has the Food and Drug Administration contacted the makers of Prevagen?

Yes, the FDA sent letters to Quincy Bioscience Manufacturing relating to mislabeling of the supplement and unlawful claims made by the company.

Is there a guarantee?

Prevagen offers a 30 day money-back guarantee. You can return any portion of the supplement for a complete refund of your money.

Do you know of any special deals or discounts on Prevagen?

The only discounts and special deals on Prevagen include savings if you order multiple bottles. However, the past few months have been wild with our readers taking advantage of Leptigen’s Special Trial Offer, which is just the cost of shipping and handling. Click here to try it out.

53 User Reviews About Prevagen

Leave comments below
  • 1
    Andrew Chinn

    FDA warning issued in 2012 about MANY sideeffects including diminished capacity in patients with MS. Also causes issues with seizure disorder. My spouse has both so – can’t take it here.


  • 2
    Jean Avanzato

    I would like to know the side effects from prevagen. Thank you.


  • 3

    Prevagen appears to be a protein (apoaequorin). Usually proteins cannot pass thru the intestinal tract and get into the body without first being broken down to the constituent amino acids. How does Prevagen avoid this problem ? If it really enters the body as an intact protein, I would be concerned about allergic reactions ?


  • 4
    Jose lopez

    Can prevagent induce seizure on an epileptic person


  • 5
    Tommy Turner

    I have been taking Prevagen for several years…almost since it first came out. I do believe it is helping but I was wondering if it could cause side effect of eye hemorrhages?


  • 6
    Your Name

    Does prevegen contain garl I c onions chives or shallots


  • 7
    Peggie Zahm

    Thanks for a great post


  • 8
    Margie Seaux

    I have been having swelling in one of my legs, i would like to know if Prevagen can cause this. I have found that my memory is better since taking Prevagen.


  • 9

    does it trun your stool green?


  • 10
    Ernie Jeffrey

    is Previgin over the counter, or perscription ?


    Your Name

    Over the counter. Should find it in the vitamin section.


  • 11
    Teri Rockenstein

    My father has high BP, Diabetes and Parkinson’s. He saw an advertisement for Prevagen and wanted my mother to purchase some, however, I am wondering if there will be any negative effects from adding this to his regular medications. I know Parkinson’s has a list a mile long of medicines that do not work well with what he takes now. He is excited about trying this so, if anyone can let me know, I would appreciate it.
    Thanks. Teri R.


    richard inwards

    i have had a heart valve replacement and wonder if prevagen


  • 12
    Jack Trautman, Ph.D.

    If your diet doesn’t contain an adequate and balanced amount of protein, it is possible that prevagen does help memories. There is no way that entact prevagen can survive the hydrolysis of pepsin, trypain, chymotrypain, carboxypeptidase and collagenase in the human digestive system. Since a FDA 510K is not required, the average person should simply consume a variety of animal and plant proteins.


  • 13

    I read some one took prevagen and had a stroke My husband has high blood pressure tell me the truth should he take this??


  • 14
    Marshall Van Meter

    Prevagen is reportedly a protein extracted from jellyfish that improves brainpower. If you swallow one of these pills, the gastrointestinal tract will take this protein, break it up into its constituent amino acids, then absorb them, then the body will use the amino acids to build whatever proteins it feels it needs, not the original protein. If you are buying these pills at approximately $1.33 for 10 mg, you are paying approximately $6000 a pound for a protein supplement. Whey protein purchased at Wal-Mart or the general nutrition store is a much better buy!


    Brian Lawliss

    Is this person a Doctor? Or a Walmart Sales Assoc?


    Your Name

    That’s kinda what I wanna know lml


  • 15
    howard brinton

    how do i order


  • 16
    Bertha Podwys

    I am 92 and my problem was my short memory about dates, or remembering things going from one room to another. I decided to try Prevagen Feb 1,2015. I feel that it does help my short memory. I will know more after I have my regular Dr. check up this year, who should notice a difference in my vision or when I get my regular blood check up. Do you have any suggestions that I could request on my blood check up, like calcium or etc.???Appreciate your response.


  • 17
    robbin rfrazier

    I would like to know if this product has been tested on children that suffer from ADHD? Is it safe for children; would you recommend this product for children?



    Robin, his wouldn’t work on children because all it does is prevent calcium buildup in older people who run low on the protein that causes calcium buildup. Also see this page about strokes, seizures, law suits with Prevagen.


  • 18

    I started taking Prevagen 35 days ago. My 83 year old mom has Dementia, I’m 60 and have been experiencing memory loss myself. I decided to try it after seeing your commercial and reading about it on the web. The first week I noticed a few changes. The second week I could recall dates and info more rapidly. The third week I remembered a phone number 6 days after hearing it only once in my life. The fourth week I felt younger, more focused, on task, I felt like this 60 year old was 25 again. It is a great feeling. I am worried about the stroke and heart attack warnings. I would like yo know how many people have experienced adverse effects in any way but especially stroke, seizures, heart attacks. My family doesn’t want me taking it because of the warnings. I don’t want to stop feeling like i’m 25 again. Please advise.


  • 19

    By the second month of taking it I noticed Prevagen having some effect. It wasn’t like a lightning bolt and suddenly I rememebered everything better but there has been a definite increase in sharpness with my ability to pull up words when I was taking to someone. I was hoping it would work faster and I was hestitating on a second bottle but that’s how long it took for me to notice a change.


  • 20

    Prevagen has helped my memory tremendously. I had to take the stronger dosage and it helped me remember names, facts at work, etc. I am 74 years old.


  • 21
    Bill Case

    I am 87 year old man that is physically and mentally degraded to some extent. I have been taking Prevagen Extra Strength for many months. I have continued to lose my memory! Has Prevagen helped? Who knows? Actually, I now think it is a VERY expensive product with really no actual proof of effectiveness. My wife is three years younger, and has very similar memory problems. She DOES NOT take the Prevagen and seems to have about the same memory problems that I have. Of course that is not proof of anything, but it does NOT verify that Pregagen is so very effective!



    It is likely that you have a fungus outbreak that is causing your mental decline, thereby over-riding the benefits of Prevagen. I recommend that you treat for fungus by implementing the Phase-one diet (search “Know the cause” by Doug Kaufman) then attack the fungus with anti-fungal foods and supplements.


  • 22

    I bought this product last year, it is the worse, while i was on school, my memory went bad, the 2 times i use it, i still have one bottle less, and wont use it ever again, after i stop use prevagen my memory went to normal, i do better now with out, just using omega 3 , ginseng, i feel this people is stealing money with a horrible product that we can even end loosing our memory if keep using their bad product. FDA will never approve this product us just no safe.


  • 23

    After seeing the amazing results in a friend, I asked her what she was taking and she told me about Prevagen. I had not seen her that Sharp in years! I have been taking it for about two months and have noticed a BIG difference in my cognitive ability and my memory. And, it didn’t take but one week to notice the difference. My recommendation is to buy one bottle and see for yourself – my guess is you will continue to take it. I’ve tried Omega 3’s and various fish oils and never noticed a difference. But, this product really works! My job performance has increase tremendously. Can’t say enough…even have my husband taking it now.



    I am interested in this product and was wondering what age Laurue is as i noticed the more negative responses were those who were older. i am in my 50’s. That may make a difference at what point u start using this. the younger the better result? just wondering.



    Hi Helen! I’m 63 and when I started trying Prevegen, I noticed a quicker recall in three days. My wife is 48 and she noticed a difference after 1 week. My favorite Aunt, who is 78 tried it and after 3 weeks, noticed the same effect that I had. It is absolutely worth a try. The the only thing you have to lose is a bad memory!


  • 24

    My good friend started taking Prevagen a few months ago and has had a small miracle happen. She had a poor memory, and some learning disabilities that became embarrassing at her fast-paced job, but since taking it, she has noticed a huge difference. She feels so amazed by the results, she gave me a bottle. it is helping me with my post ‘chemo-brain’ fog. So much so that I splurged on a 3 month supply! I don’t go in easily for these sort of things, and sincerely don’t believe my success is the result of some placebo effect. I feel clearer in my thinking, my memory has improved, and you can’t make this stuff up!


    Your Name

    This comment seemed helpful


  • 25
    Anne Wyckoff


    While I’ve had the same concerns as you (+17 years of medical study involving pathology), there IS something odd happening to some consumers. I, for one, am very immune to the “placebo effect,” yet after trying this for 2 weeks, I suddenly woke up with name-recall. My son noticed this, because I had to ask him names constantly in the past. I wouldn’t have tried prevagen if I’d looked into the molecular structure first, however (a rare lapse in judgement)
    Do you think there’s a possibility that the EDTA is chelating something harmful with some people? I noticed another positive review from a scientist who used it for a trial but then stopped. It bewildered him as it does me.


  • 26
    Nadine Anderton

    I always suspect nutritional supplements that come from exotic (like jellyfish) sources rather than from food-obtained nutrition. This allows the makers and distributors to make big bucks – something like the pharmaceutical companies? It sounds good, but it totally unavailable to someone like me on a very limited income. So I guess I’ll just have to die from my brain problems, which may or may not turn out to be Alzheimers.


  • 27

    Amino acids cross the blood-brain barrier. Whole proteins do not. Any beneficial effect of apoaequorin is lost as soon as it is digested into amino acids like any other protein. It is simply untrue to claim that apoaequorin taken orally has any effect in the brain whatsoever.



    Have you actually taken it?


  • 28
    JK Freeze

    Jason says “Disregarding the sketchy clinical trials cited, the active ingredient is a protein compound (Aequorin) that gets broken down upon digestion into its component amino acids. While Aequorin certainly does bind calcium, even if it did survive digestion it is unlikely to pass the blood-brain barrier”

    Jason, being a bio-chemist, you DO know that ALL amino acids pass the blood brain barrier, don’t you?

    also, Prevagen does NOT contain EDTA.


    Ed B

    Check the label…it has EDTA


  • 29

    I am 63 years old. I started taking Prevagen for brain function shortly after being told there was some evidence of the beginnings of dementia or a stroke from a CT Scan.
    The day before I began taking it was the last time I walked into a room and forgot what I went into it for. The last “senior moment” I had was 14 days after beginning the program. Doctors in other countries are injecting it directly into the brains of dementia patients with amazing adn quick results. There were some sites on wehre you could get this day surgery in Canada, but all of them have been suppressed by our “friends” in Big Pharma industry. So now the operation is given all over the world to everyone but Americans. We can no longer find out where to take our loved ones to get it. The FDA has already started posting “warning” conumers sites that Prevegen is useless, and soon enough it will be “risky” since it is not FDA approved (unlike the black box pharmacuetical crap they are selling). If you have a loved one who is showing some signs of eary dementia — FOR GOD SAKE!!!! — spend the $90 and get them a bottle. It’s cheaper than #$**& Aricept!!!! Of course they will have to contiue to take it, but isn’t your loved one’s mind worth it to you???? As for ME, I’m going to continue protecting my mind with the 10 mg bottle. I’ll be d*$#ed if I’ll let my brain rot on the Aricept crap, while the doctors and druggists keep raking in the loot!!!


  • 30

    Michele, biochemistry is not some religion one simply has faith in, although placebo effects are sometimes helpful. Jason is completely correct. Prevagen is a bold-faced marketing scam. One look at the structure of this protein, with its secondary structure, and it is readily apparent that the protein, even if it could be transported through the blood-brain barrier through endothelial vesicular transport, would never survive denaturation in the stomach. These guys are selling the placebo effect and the rest is snake oil. Take the omega 3s, they, at least offer real benefit.


    Your Name

    You are so wrong! I am telling you after 35 days my mind is clearer, I am more focused, I can remember things my kids can’t with no effort. This stuff is priceless!!! I feel 25 again and I am 60. Do unless you have tried it yourself you should shut up and let the rest of us help our brains.


  • 31
    sherry oglesby

    seem to feel worse on this my thinking isworseand ihave an increasted bp
    what do others say


  • 32
    Joy zuer

    Thank you for the reviews. Upon taking prevagen, lots of energy, could stay focused, but could not sleep on this product. Independent studies would make it morally sound. Don’t you think?


  • 33

    Having a degree in biochemistry, it’s my opinion that Prevagen does almost nothing more than the placebo effect. Disregarding the sketchy clinical trials cited, the active ingredient is a protein compound (Aequorin) that gets broken down upon digestion into its component amino acids. While Aequorin certainly does bind calcium, even if it did survive digestion it is unlikely to pass the blood-brain barrier and is more likely to bind calcium in the body first. At best it is a dose of protein and, by the looks of the other ingredients, EDTA, which is known to chelate (ie., bind) calcium and other metal ions like iron. This could probably pass the blood-brain barried, however higher doses of EDTA (2 g/kg) are known to be toxic to lab rats and the quantity of EDTA in Prevagen is unreported. If the purported effects of Prevagen work as a placebo for you or your loved one, by all means, continue. Though in my opinion the best way to promote healthy brain function is through intake of omega-3 fatty acids found in fish oils. These have been rigorously proven to lower risks of depression, suicide, Alzheimer’s, Parkinson’s, psoriasis, and even benefit pregnancies. These essential oils (EPA and DHA, specifically) can be taken as pills as well but do look for organic, ethically-farmed products.



    Thank you for your insite on this product. I too have studied biochemistry and feel the same should be said about the product. It is easy for some companies to claim the like, but not reviel the underlying…easy if one understands the language of chemisry…..so people ask questions and look up info before ypu buy anything!…..fish oils as well as primrose is great….



    Oh you of little faith. I have been taking it and I remember street names that eluded me and can contribute to conversations. That is so nice. My mom said since she has been taking it she is doing all her crossword puzzles without looking in the back for answers. My daughter has been taking it and reports that she doesn’t feel the need to close doors and straighten silverware and everything else in sight (OCD). Whatever it does, it’s helpful. Unless you have a nee-d and have tried it you should keep your negative input to yourself. You are a nay-sayer. Too much learning and not enough life experience or graciousness. Good day!


    Your Name

    Example: I was told a phone number once and did not write it down, 6 days later someone asked me if I new that persons phone number. It was as if I had written it down in my head. I have had 100’s of moments like that. I had written an order for a childs birthday party at my sons business, someone asked me 3 weeks later if I could call the childs mom. I had taken the order over the phone and had never met her. I had never even glanced at the order again in 3 weeks. I remembered her name, his name, his age and what color his cake was to be decorated in. It was amazing!! And my to do lists are a thing of the past. Its in my head ready for instant recall. I wouldn’t consider stopping this amazing medicine.


  • 34

    How does it affect Calcium metabolism in bones? Jellyfish don’t have bones!


  • 35
    Maria Steiselboin

    A person with advance diseace like anzhaime this can help, or is too late?


  • 36
    Maria Steiselboin

    A person with anzhaimer deseace in advance state this can help? because she can’t talk o walk?


  • 37

    could this supplement help migraine headache or headache pain?


  • 38

    Since it is a dietary supplement,can’t you lose weight from it ?


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