By Summer Banks on Dec 29, 2017

Nootropics appear to be a rapidly-growing trend in the supplement industry, with some of the most popular ones being L-tyrosine supplements.

Those who are constantly coping with chronic stress might find themselves easily attracted to the claims that L-tyrosine manufacturers make about it being a stress-reliever.

But, just how much of this is true? Can L-tyrosine reduce your stress and give your brain the boost it needs? Read on to find out.

What is L-Tyrosine?

As you might have guessed from the “L” in its name, L-tyrosine is an amino acid.

Your body utilizes this amino acid to create catecholamines – in particular, dopamine and norepinephrine.

Dopamine is a neurotransmitter involved in creating motivation, arousal, reward, and motor control.

Norepinephrine acts as both a neurotransmitter and hormone, performing functions in both the sympathetic and central nervous systems (SNS and CNS, respectively).

Both of these neurochemicals are essential for your brain and body to properly function.

A lot of the L-tyrosine you get comes from your diet. It is present in dairy products, chicken, and soy.

However, some of us simply do not get enough of it from our diets.

While L-tyrosine deficiency is considered to be a medical rarity, those with thyroid issues (such as hypothyroid) tend to experience lower levels of L-tyrosine.

L-tyrosine does not seem to directly increase levels of dopamine and norepinephrine, at least according to a lot of the research that has been conducted over the years.

Your body should be doing a good job of regulating catecholamines on its own and converting L-tyrosine into L-DOPA.

In other words, you might not increase your norepinephrine and dopamine levels just by getting extra L-tyrosine.

There is, however, some evidence to suggest that L-tyrosine acts as a buffering system against intense physical and emotional stress.

So, while it does not relieve stress, L-tyrosine seems to have some ability to protect you when your cortisol (your “stress” hormone, released by the adrenal gland) level gets too high.

L-tyrosine is an amino acid that acts as a buffer against stress, even though it is not directly a stress reducer.

It is acquired from food sources and is sometimes found to be depleted in those with thyroid diseases. [1] [2] [3] [4] [5]

What is L-Tyrosine

L-Tyrosine Uses

The number one use of L-tyrosine is probably pretty obvious by now.

Many people who try it use it for its ability to protect them against cognitive decline due to physical and emotional stress.

Those who take it to reduce stress tend to report that they experience some relief when taken during or just after a bout of acute stress.

Of course, L-tyrosine itself does not seem to be an actual stress-reliever, although results seem to consistently show that it acts as a buffer.

L-tyrosine also appears to have an impact on cognitive abilities, even while the body and mind are under stress.

In one military study, it was found that L-tyrosine was effective in lowering blood pressure in a single week. [6]

The cadets who were being studied were all undergoing a rigorous and stressful combat training course, and those who were provided with L-tyrosine showed improved cognitive abilities during memory tasks.

Additionally, L-tyrosine seems to provide a cognitive boost in sleep-deprived individuals.

A 1995 study of on this subject revealed that sleep-deprived participants performed better in assigned cognitive skills (including memory) tasks than their peers who received a placebo. [7]

These results make L-tyrosine seem like a helpful nootropic for working individuals and college students who often don’t get enough sleep but need to be cognitively alert.

About cognitive abilities, it appears that L-tyrosine supports an elevated degree of cognitive flexibility. [8]

Essentially, this means that those who use L-tyrosine might be better able to shift between thoughts and tasks than those who do not take this amino acid.

This might be due to L-tyrosine’s connection with dopamine, which is known for stimulating cognitive flexibility.

Additionally, it appears that L-tyrosine might be useful in treating individuals with attention-deficit hyperactivity disorder (ADHD).

In 2011, one study revealed that the majority of its participants (77%, to be exact) benefitted from using L-tyrosine alone. [9]

Also, some studies have shown that L-tyrosine can enhance the effects of prescription ADHD medications, generating more cognitive flexibility, focus, and memory overall.

Finally, L-tyrosine is becoming more frequently found in supplements used by athletes.

Since it seems to promote a better focus on tasks at hand, athletes find benefit in this amino acid as they use it to fluidly switch between exercise tasks and intensities.

L-tyrosine is most commonly used by those looking to boost their cognitive performances.

Those who use it want to reap the benefits that come with clearer cognitive processing and task mitigation.

Thyroid Conditions

How Does L-Tyrosine Affect Your Thyroid?

The subject of L-tyrosine and the thyroid deserves specific attention here since it is so commonly used by those with thyroid issues.

The thyroid and L-tyrosine are inextricably linked since the thyroid gland uses tyrosine and iodine in the hormone production process. [4]

Your thyroid converts phenylalanine into tyrosine before it creates the hormone.

When thyroid function is low (which is known as hypothyroidism), your thyroid gland is not making and secreting enough hormones. Hence, you have a deficiency.

Since your thyroid is crucial for performing many bodily functions, having it be out-of-whack can be nothing short of nightmarish.

Those with hypothyroidism might have a tyrosine deficiency, which could potentially cause the under-activity in the thyroid gland.

Supplementation with L-tyrosine might, therefore, increase the availability of it in the body and help the thyroid gland make more hormones.

However, if you have hyperthyroid (an overactive thyroid), you probably already have too much L-tyrosine in your body and do not need to supplement it.

Your thyroid gland needs an optimal amount of L-tyrosine, as well as iodine, in order to make its hormones.

Those with underactive thyroids most likely do not have enough L-tyrosine available and might need to consider supplementation.

The Brain and Male Performance

L-Tyrosine Benefits

L-tyrosine has quite a few well-documented benefits.

Regarding L-tyrosine depression benefits, dopamine levels and depression are intertwined due to dopamine’s role as a mood regulator. [10]

If you don’t have enough dopamine in your system, depression can result. On the other hand, excessive dopamine has been linked to psychosis.

For those with mild to severe depression, L-tyrosine might be able to provide that necessary boost by encouraging more dopamine stimulation in the brain.

Those who are struggling with aspects of cognitive decline might find L-tyrosine to be beneficial.

Mild cognitive impairments (MCIs) sometimes progress into full-blown forms of dementia, including Alzheimer’s. [11]

Those with thyroid deficiencies, traumatic brain injuries (TBIs), and various autoimmune diseases seem to experience mild cognitive impairments at earlier ages than others.

L-tyrosine might not be able to stop the process of cognitive decline, but it might be able to slow it down.

Since L-tyrosine has been shown to increase cognitive flexibility, it could at least provide temporary improvement regarding short-term memory functions and maintaining focus.

Of course, we cannot forget to mention the buffering benefits L-tyrosine has against stress.

Stress and cognitive performance (and, therefore, cognitive decline) seem to be highly correlated.

When you are under stress, your adrenals secrete elevated amounts of cortisol, which normally regulates blood sugar, inflammation, and plays a role in the prevention of nerve damage.

An excessive amount of cortisol can lead to [12]:

  • Chronic fatigue
  • Depression
  • Pain along the spine
  • Dysregulated blood sugar (sometimes in the form of hyperglycemia or hypoglycemia)
  • Slow healing of wounds
  • Abnormal menstrual cycles

Stress then exacerbates these symptoms and turns into a vicious cycle.

L-tyrosine might be able to replenish the levels that have been depleted due to the overproduction of cortisol.

At the very least, L-tyrosine appears to have short-term benefits in enhancing cognitive functions that have been affected by stress.

Also, although reviews are mixed regarding L-tyrosine weight loss effects, it appears that stress-induced weight gain could be reduced by taking L-tyrosine.

However, L-tyrosine weight loss efforts would need to be paired with healthy diet and lifestyle choices to maximize success.

L-tyrosine benefits still warrant a lot of research, but this amino acid seems to have a positive impact on those struggling with stress and cognitive decline.

There also seem to be some L-tyrosine depression benefits.

Disorders stemming from stress and anxiety are the most common illnesses in American today an affect 18 percent of the U.S. population ages 18 and older.

Stress and anxiety are different and have different effects, here’s a rundown on how each of them.

l-tyrosine stress and anxiety


Contrary to what you may think, not all stress is harmful for the health.

There are two main types of stress.

Eustress is the positive energy that gives you the drive to accomplish things.

In moderate amounts, this kind of stress can energize you and give you a good buzz.

It can also elevate your mood and boost your immune system.

Distress is the negative factor that you need to watch out for.

If this starts to build up it will begin to adversely affect your health.

It can ultimately lead to debilitating or fatal diseases including the six leading causes of death – cancer, heart disease, lung disease, cirrhosis of the liver and suicide.

There are a number of common signs and symptoms that will indicate if your level of stress is high.

Symptoms of Stress

Signs and symptoms that your stress level is too high include:

  • Tightness in your neck and shoulder muscles.
  • Headaches, particularly at the base and crown of your head.
  • Insomnia or frequent walking throughout the night.
  • Fatigue and poor concentration.
  • Depression and loss of interest in activities you normally find pleasurable.
  • Irritability, depression and mood swings.
  • Loss of normal appetite.

Stress and Your Health

Your body responds to stress by releasing hormones, such as norepinephrine and cortisol.

This causes the release of energy stored in the muscles, boosting your heart rate, raising your blood pressure and slowing down metabolic function such as immunity, digestion, growth, and reproduction.

Symptoms of stress may even be affecting your health although you are not aware of it.

Immune System

Stress can wreak havoc on your immune system.

When you’re under stress, the cells in your immune system are unable to respond adequately and instead cause inflammation, leading to a higher risk of illness and disease. [13]

Digestive System

Stress can cause a number of digestive issues including acid reflux, nausea, esophageal spasms, constipation, and diarrhea.

It can also worsen other disorders such as inflammatory bowel disease, stomach ulcers and celiac disease.


When you’re suffering from chronic stress, a restful night’s sleep may seem impossible. [7]

If you’re suffering from insomnia, you will soon begin to notice that you have difficulty concentration, problems with your short term memory and possibly irritability, anxiety and depression.

sleep and weight loss


In spite of the fact that anxiety disorders America’s most common mental illness, and are easily treatable, only around one third of sufferers actually received treatment. [14]

Still, anxiety disorders cost more than $42 billion a year, that’s around 33 percent of the total U.S. mental health bill.

Anxiety affects women and men equally and usually occurs around age 14-19 years, although one third of sufferers begin to experience symptoms during childhood.

There are a number of different types of anxiety disorder.

Panic Disorder

This condition causes sufferers to experience sudden and repeated feelings of terror, often for no apparent reason. [15]

Other symptoms include a panic attack (hyperventilating), pains in the chest, rapid or irregular heartbeat, and choking feelings.

Post-traumatic stress disorder (PTSD)

PTSD is a condition that may arise as a result of a terrifying or traumatic event such as a natural disaster, experience of war, physical or sexual assault or unexpected death of a loved one.

Symptoms include frightening flashbacks to the trauma and emotional numbness.

Social Anxiety Disorder

Also known as social phobia, this disorder leaves the sufferer feeling overwhelmingly self-conscious or afraid when in everyday social situations. [16]

The anxiety tends to be focused on behaving embarrassingly or being judged negatively by others.

If you are living with an anxiety disorder, you do not have to suffer alone.

Whichever anxiety disorder you are suffering from it can be treated successfully by a qualified mental health professional.

Studies show that one of the most effective therapies for this condition is cognitive-behavioral therapy (CBT).

CBT can help you understand your anxiety triggers and learn strategies to control them.

Behavioral therapy can empower you with ways and means to break patterns of undesirable behavior and negative thinking that can lead to feeling of anxiety.

You therapist can also help you learn breathing and relaxation techniques.

Sometimes, along with therapy, your health care provider may recommend appropriate medication.

The doctor who prescribes you medication will carefully monitor your progress and check closely for any side affects you may experience.

Depression and Psychological


The Centers for Disease Control and Prevention (CDC) estimates that as many as one in ten adults in America reports suffering from depression, there may be many more sufferers who remain anonymous. [17]

Depression is a serious illness that can be debilitating and costly for sufferers. It can also have negative effects on other chronic conditions such as diabetes, cancer, obesity and cardiovascular disease.

Long-term depression can also lead to reduced productivity levels and time off work.

Although most people have periods in their life when they suffer from depression, depression can often accompany an anxiety disorder.

In this case is sufferers experience sadness, loneliness, and fear on a daily or almost daily basis.

Almost half of Americans diagnosed with depression also suffer from an anxiety disorder.

Stress and L-Tyrosine

L-Tyrosine is an amino acid that your body uses to produce dopamine and noradrenaline.

Dopamine is a neurotransmitter; this means it is responsible, in part, for transmitting signals back and forth between the nerve cells in the brain.

Noradrenaline, also known as norepinephrine, is a hormone and also a neurotransmitter.

During times of stress, production of both these chemicals is triggered.

Over stimulation of these chemicals can cause negative effects on brain functions, such as poor concentration and memory deficits, and can ultimately lead to autoimmune disorders, heart disease and cancer .

Some researchers believe that during times of chronic stress, the body is unable to produce enough tyrosine and that taking supplemental l-tyrosine can help reduce some of the symptoms of stress.

L-tyrosine has been shown to help improve concentration, reduce fatigue, and boost mental performance

It also assists in the production of the thyroid hormone, coenzyme Q10 which is an antioxidant.

L-tyrosine may also help to prevent panic attacks by reducing anxiety.

Because it aids in the production of melatonin, L-tyrosine can also aid restful sleep.

L-tyrosine can be bought over the counter as a supplement in tablet form.

It’s available in 250 mg, 500 mg, and 750 mg pills.

You should take L-tyrosine supplements at 30 minutes before meals, three times a day.

Taking a copper and folate supplement at the same time help L-tyrosine trigger brain chemicals.

What Does 5-HTP Do

L-Tyrosine and 5 HTP

L-tyrosine can be taken completely on its own. However, there are some individuals who have used L-tyrosine and 5 HTP together. In the world of supplements, doing this is called “stacking.”

In other words, two different substances that achieve similar effects can be synchronized to maximize the benefits of both.

5-HTP is a chemical created from an essential amino acid called tryptophan. [18]

Inside the brain, it gets converted into serotonin, which is a neurotransmitter that plays a role in multiple functions (including appetite, mood, and sleep).

Those with a serotonin deficiency tend to experience depression in relation to anxiety.

Stacking L-tyrosine and 5-HTP appears to help some individuals achieve a boost to the mood and cognitive functioning while creating a sense of relaxation.

Although L-tyrosine, when consumed in a dietary source, struggles to bypass the blood-brain barrier, 5-HTP does not.

When taken on an empty stomach as an actual supplement, L-tyrosine appears to cross more readily, as it does not have as many other amino acids to compete with regarding getting through.

L-tyrosine and 5-HTP play on different neurotransmitters but appear to work well in combination when taken as stacked supplements.

L-tyrosine is likely more effective when taken as a supplement without food.

L-tyrosine Side Effects

Taking L-tyrosine may cause the following side effects:

  • Increased heart rate
  • Agitation
  • Appetite changes
  • Difficulty breathing
  • Changes in blood pressure
  • Nausea
  • Joint pain
  • Dizziness
  • Weight loss

As is the case with most dietary supplements, there are some known L-tyrosine side effects that you need to watch out for.

However, it should be noted that L-tyrosine is considered safe for many adults to take either in short-term spurts or when topically applied to the skin.

It is unclear as to whether or not L-tyrosine is safe to give to children or women who are pregnant or breastfeeding. [19]

The biggest potential for side effects can be experienced by those with Graves disease (an autoimmune disease that causes hyperthyroidism) or hyperthyroidism. [20]

Both of these diseases involve an overproduction of tyrosine within the body, and taking L-tyrosine will make these conditions worse.

Also, those who suffer from chronic migraines should be aware that, due to dopamine imbalances in the brain, consuming L-tyrosine could make their migraines worse.

Reports of this happening, though, seem few and far between.

L-tyrosine is probably safe for most adults to take. However, those with overactive thyroids or chronic migraines should avoid it.

L-Tyrosine Uses

L-Tyrosine Interactions

Since L-tyrosine is already something made within your body, there are not too many substances that it will have a negative interaction with.

In fact, there is no hard-and-fast scientific proof that L-tyrosine has negative interactions with medications or other supplements.

However, there is some potentiality for negative interactions with Monoamine Oxidase Inhibitors (MAOIs) like Selegiline, Marplan, Nardil, and Parnate.

L-tyrosine is known to elevate blood pressure in those taking some of these MAOIs. [21]

Since L-tyrosine is a precursor to the hormones created by the thyroid gland, it could negatively interact with synthetic thyroid medications for hypothyroid, such as Synthroid.

If you are taking Levodopa (L-DOPA) to treat Parkinson’s, you should avoid consuming L-tyrosine. L-DOPA could potentially interfere with how your body absorbs L-tyrosine. [22]

L-tyrosine has a few potential interactions with prescription drugs and should be taken with caution by those on MAOIs.

Those taking synthetic thyroid meds or L-DOPA would probably do better to avoid taking L-tyrosine.

L-Tyrosine Warnings

Only a select few L-tyrosine warnings can be given.

gain, L-tyrosine is not something that those with an overactive thyroid should take, and taking L-tyrosine with synthetic thyroid meds could boost your levels up too high.

There have not been any studies that show that L-tyrosine is safe to give to children, so it should only be taken by adults for the time being.

L-tyrosine is likely safe for most adults who do not have thyroid issues. Thyroid medications might interfere with L-tyrosine.

L-Tyrosine Dosage

For most L-tyrosine uses, dosages land on the smaller side.

A dosage of 250 mg lands you on the lower end of the dosage spectrum and seems to be effective at treating milder cases. [23]

Generally-speaking, a standard dosage is about 500 mg and can be taken for acute stress symptoms before consuming a meal.

Take L-tyrosine as directed either 30 minutes before or 2 hours after eating.

L-tyrosine is typically taken in the morning and can be spaced out to several days per week.

Ideally, you should not be taking L-tyrosine for a long time. Instead, plan on taking it for a short-term period.

You should always talk to your doctor before taking your first L-tyrosine dosage so that you know what kind of L-tyrosine interactions you could be getting mixed up in.

Expect to take 100-500 mg of L-tyrosine on an empty stomach. This is something that should be done on a short-term basis under the guidance of your doctor.

L-Tyrosine Alternatives

There are a few L-tyrosine alternatives available. N-Acetyl L-tyrosine (NALT) is the “other” tyrosine. [24]

NALT is said to offer a greater amount of bioavailability since it is highly soluble in water because it is the acetylated version of tyrosine.

However, your body does not directly convert NALT into tyrosine.

In some laboratory studies on mice, it was found that NALT was less effective at crossing the blood-brain barrier than L-tyrosine, rendering it less impactful overall in the test subjects.

In other words, don’t believe the supplement world’s hype behind the supposedly superior NATL.

L-tyrosine seems to be at least as effective, if not more so.

L-tyrosine’s chief competitor, NATL, doesn’t seem to hold much water when compared in laboratory studies. As far as alternatives go, L-tyrosine still seems to be the best bet.

What Does l-Tyrosine Do

The Final Verdict on L-Tyrosine

L-tyrosine is not a miracle cure for stress, depression, or cognitive decline.

However, it seems to hold some benefits for those with tyrosine deficiencies.

Those with hypothyroidism are starting to turn to L-tyrosine as an alternative to potentially problematic synthetic thyroid meds.

While L-tyrosine supplements might have a few negative side effects and drug interactions, on the whole, it seems relatively safe for most adults to consume as directed.

Article Sources
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.