There’s quite a buzz surrounding this citrus extract. So our in-depth review focused on Sinetrol side effects, ingredients and clinical studies. Additionally, user comments and remarks were taken into consideration. Then, we summarized and refined to give you the info you need.
What is Sinetrol?
To start, Sinetrol is an ingredient, comprised of citrus polyphenolic extracts of red orange, grapefruit, and orange.  Supposedly, the extract works by inhibiting the PDE enzyme and stimulates lipolytic activty.  In essence, it enhances the fat-burning process. There are also claims it may help boost metabolism and speed up fat loss.
Sinetrol was introduced by France-based company NB Consulting. Throughout the official website, there’s information relating to use, research and applications. We like that we found some favorable reviews and that it contains a few natural ingredients, but read on…
Minimal Results – “Concerning?”
One issue we have is with minimal weight-loss results. “There are numerous user comments and reviews posted online regarding results from Sinetrol ingredients,” said our Research Editor. “But, the science behind it paints a different picture.”
One customer stated, “I noticed no noticeable weight-loss or effect from the product.”
However, a different person commented, “It reduces my appetite and I think I’m losing some weight.”
The opposite was found in other reviews of Sinetrol.
According to the International Journal of Food Sciences and Nutrition, “they received daily for a 12-week period 900 mg of a Citrus-based polyphenol extract, Sinetrol…the efficacy of the supplement improve both overweight process and correlated skeletal muscle mass metabolism.” 
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Reviews of Sinetrol – “Discouraging?”
Unfortunately, there are quite a few discouraging user comments posted online for Sinetrol. For example, one person said, “Not sure about it. I have been on them for 2 weeks and I have not seen any results at all.”
But, a different customer revealed, “Did the research and haven’t found where anyone lost weight.”
As is the case most of the time, there are positive reviews of Sinetrol.
Another posted, “I read that it offers antioxidant support, so that’s a good thing.” 
The research we’ve conducted has revealed that if there’s a certain aspect of a weight-loss ingredient or diet product that is quite difficult or bothersome (minimal results, discouraging user comments, side effects) the likelihood of long-term success is slim. Therefore, if Sinetrol does fail to produce real effects in a lot of people, this could be a major dilemma.
The Science – “Find Any Evidence?”
We at DietSpotlight look for solid science used to support any applicable weight-loss claims. Regarding Sinetrol, there are studies relating to the use of citrus extracts and improved cardiovascular health, fat loss and burning.  The only concern was the amount administered and the time-frame to see results. While we like that there are some studies, the results are mixed.
The Bottom Line – Does Sinetrol Work?
Will Sinetrol help you lose weight? Well, we like that it contains natural ingredients and that there are some studies relating to efficacy, but the lack of concrete evidence showing users will burn fat and improve long-term weight-loss leaves us concerned . There’s also the issue of consumers no seeing results and the presence of discouraging reviews.
If your’re looking to lose those extra pounds, we suggest going with a product containing ingredients backed by science and connected to positive dieter reviews.
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Previous Sinetrol Review (Updated December 29, 2011):
What You Should Know about Sinetrol
Sinetrol is more likely to be added to other weight loss supplements than found for sale as a standalone product. Created by NB Consulting, a French company, Sinetrol is a fat burning ingredient that can be purchased by supplement companies for use in their products. Sinetrol is derived from fruits and claims to be a 100% food product. There are no stimulants in the fat burning ingredient, which is uncommon for a fat burner. When searching for Sinetrol, we could not find any product listing this ingredient. Information on the official website was last updated in 2008.
List of Sinetrol Ingredients
Extracts of red orange, grapefruit and citrus.
Sinetrol is a relatively unknown ingredient in the weight loss world. The ingredient claims to have fat burning potential, but there are no stimulants to increase heart rate. Stimulants are commonly used as fat burners because increased heart rate leads to calorie deficit which means the body will burn more calories stored as fat. If Sinetrol does have fat burning capabilities, they would not reside in this theory.
Interestingly enough, the name Sinetrol is not far off from synephrine. Synephrine is derived from the bitter orange tree and is a fat burning ingredient in many weight loss products. Synephrine is a stimulant, however, and in some cases can cause health issues in dieters who use the product for extended periods of time.
Whether Sinetrol and synephrine is the same product, we cannot be sure. The Sinetrol website offers no information on the exact make-up of the ingredient. No products are listed that contain the ingredient either. What is offered is a list of product companies that offer Sinetrol for sale. None of these companies are based in the United States and none currently sell weight loss supplements containing the ingredient.
There is no pricing information available for Sinetrol as it cannot be purchased by an individual for home use.
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Advantages of Sinetrol
- All natural sources.
- The official website offers a list of retailers selling Sinetrol.
Disadvantages of Sinetrol
- There are no known weight loss supplements using the ingredient.
- Sinetrol may be a brand name for synephrine.
- Sinetrol cannot be purchased by dieters directly.
- The official website was updated more than two years ago.
If Sinetrol was a good fat burning ingredient, weight loss companies would not need to include stimulants in their formulas. There is no known way of increasing fat burn without increasing heart rate. Stimulants increase heart rate and Sinetrol does not contain any stimulants. Dieters wanting to try Sinetrol to increase fat burn may have difficulty locating a supplement using the ingredient. We could find no supplements listing Sinetrol on their ingredient lists and the official website offers no leads in this regard.
Sinetrol Questions & Answers:
We sorted through hundreds of user comments about Sinetrol to form this helpful FAQ.
What are the side effects of Sinetrol?
Sinetrol side effects may include a slight boost in energy, based on user comments.
What are the ingredients in Sinetrol?
Sinetrol ingredients are sweet orange, blood orange, and grapefruit extracts.
Does Sinetrol work?
There’s a wealth of information presented on the official Sinetrol website about the benefits of the extract. We found several studies showing users noticed decreases in abdominal fat, body weight and waist and hip circumference.  We also located research where it was shown to help boost skeletal metabolism ; but only during the 12-week trial.
How much does Sinetrol cost?
On Amazon, a box of 90 capsules is $4.99.
How should I take Sinetrol?
As said on the label, you should take two capsules, twice a day with a full glass of water 30 minutes before your meal.
Can I take Sinetrol if I have a health condition?
Before taking supplements such as Sinetrol, you should talk to your physician if you have heal problems, if you are pregnant, nursing, under the age of 18, or taking other prescriptions.
What do users like about Sinetrol?
Users taking Sinetrol said they experienced a loss in appetite and increase in energy.
What do users NOT like about Sinetrol?
There weren’t many negative comments about Sinetrol.
How do I contact Sinetrol customer service?
You can contact the customer service of Sinetrol by going to their contact us page in their official website, calling the corporate headquarters at 1-973-204-0460 or by mailing letters to Fytexia Corp. c/o Pramex International Corp. 1251 Avenue of the Americas New York, New York 10020.
Does Sinetrol come with a guarantee?
There was no guarantee on the official website.
Can I take Sinetrol with other fat burners?
We would recommend you talk to your physician before taking Sinetrol with other fat burners.
Do you know of any special deals or discounts on Sinetrol?
We weren’t able to find any special deals or discounts on Sinetrol. However, our readers have been going wild over the last several months taking advantage of the Special Trial Offer from Leptigen. To learn more about it, click above.
Sinetrol User Tips:
7 Top User Tips
Over the years, we’ve come to realize that people using products that contain Sinetrol have something to say. After consulting thousands of reviews and user comments, we collected these tips to help you learn more about this ingredient.
“T was looking for a boost to help me lose some extra pounds. It took two months to see any results.” Jenn
“I take it before I go to bed to help me with late night snacks.” Bibi
“I felt very ‘speedy’ especially at night when I began to sweat from this product so I only take it during the day.” Marty
“I suggest taking this with plenty of water.” Sherry
“You have to follow a diet plan if you want to see results.” Lisa
“If you’re willing to commit to something and exercise and eat right if you add these pills think that they will help you burn off the fat.” Sabrina
“You still need to exercise and watch what you’re putting in your body if you want to see results.” Cyrus
Sinetrol Scientific Abstracts:
Sinetrol is known to have 2.1 more activity than guarana 12% caffeine all while possessing 3 times less the amount of caffeine. There were two groups of participants (10 individuals in each group) with a body mass index high enough to be considered overweight were observed throughout a 4 and 12 week study where they ingested 1.4 g per day Sinetrol as well as placebo. Participants in the Sinetrol group experienced a decrease of body fat percentage with a substantial difference of 5.53% and 15.6% respectively, following the 4 and 12 weeks. Body weight of the participants reduced with a large difference (2.2 and 5.2 kg respectively) following the 4th and the 12th week. The effects of weight-loss were attributed to Sinetrol polyphenolic composition and its synergistic activity. Sinetrol was found to be a powerful trigger of PDE (cAMP- phosphodiesterase) at 97% in comparison to narangin , cyanidin-3 glycoside and caffeine. In conclusion, it has been indicated that that Sinetrol contains powerful lipolytic properties which are controlled by cAMP-PDE inhibition. Sinetrol was found to prevent obesity by reducing body mass index. 
A randomized, controlled, double-blind study was carried out for a period of 12 weeks. Sinetrol-XPur was administered to overweight participants two times per day along with each meal in one group (N=47) compared to a placebo group (N=48). Hip and waist circumference along with belly fat were reduced in the tested group in comparison to the placebo group (p < 0.0001) (-5.71% versus -1.56% for waist circumference, -4.71% versus -1.35% for hip circumference and -9.73% versus -3.18% for fat). Inflammatory markers were then noticed to decrease. There was a notable reduction of oxidative stress as noticed by the decrease of malondialdehyde (-14.03% versus 2.76%) as well as an elevation of glutathione and superoxide dismutase (4.63% versus -2.36% and 17.38% versus 2.19%, p < 0.01). There were no adverse reactions noticed within the study. Results suggest Sinetrol-XPur is a useful tool for decreasing abdominal fat and reducing waist and hip circumference while enhancing inflammatory and oxidative status in overweight human subjects. 
Overweight male participants in a randomized, double-blind trial were observed following consumption of 900 mg citrus-based polyphenol extract (Sinetrol XPur) per day for 12 weeks. Before and following the intervention period, body composition, blood and anthropometric parameters were closely observed. Following the 12 weeks, metabolic framework was substantially improved with a suppression of skeletal muscle catabolism. The results of the trial indicate that over a 12 week period of time, the effectiveness of the Sinetrol XPur supplement correlated skeletal muscle mass metabolism and improved both overweight process. 
1. . Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE) (2008). International Journal of Phytotherapy and Phytopharmacology. December 7, 2016.
2. . Clinical study to assess the efficacy and safety of a citrus polyphenolic extract of red orange, grapefruit, and orange (Sinetrol-XPur) on weight management and metabolic parameters in healthy overweight individuals (2014). Phytotherapy Research. December 7, 2016.
3. A 12-week randomized double-blind parallel pilot trial of Sinetrol XPur on body weight, abdominal fat, waist circumference, and muscle metabolism in overweight men (2015). International Journal of Food Sciences and Nutrition. December 7, 2016.