There’s quite a buzz surrounding this citrus extract. So our in-depth review focused on Sinetrol side effects, ingredients and clinical studies. Additionally, user comments and remarks were taken into consideration. Then, we summarized and refined to give you the info you need.
What is Sinetrol?
To start, Sinetrol is an ingredient, comprised of citrus polyphenolic extracts of red orange, grapefruit, and orange.  Supposedly, the extract works by inhibiting the PDE enzyme and stimulates lipolytic activty.  In essence, it enhances the fat-burning process. There are also claims it may help boost metabolism and speed up fat loss.
Sinetrol was introduced by France-based company NB Consulting. Throughout the official website, there’s information relating to use, research and applications. We like that we found some favorable reviews and that it contains a few natural ingredients, but read on…
Minimal Results – “Concerning?”
One issue we have is with minimal weight-loss results. “There are numerous user comments and reviews posted online regarding results from Sinetrol ingredients,” said our Research Editor. “But, the science behind it paints a different picture.”
One customer stated, “I noticed no noticeable weight-loss or effect from the product.”
However, a different person commented, “It reduces my appetite and I think I’m losing some weight.”
The opposite was found in other reviews of Sinetrol.
According to the International Journal of Food Sciences and Nutrition, “they received daily for a 12-week period 900 mg of a Citrus-based polyphenol extract, Sinetrol…the efficacy of the supplement improve both overweight process and correlated skeletal muscle mass metabolism.” 
Reviews of Sinetrol – “Discouraging?”
Unfortunately, there are quite a few discouraging user comments posted online for Sinetrol. For example, one person said, “Not sure about it. I have been on them for 2 weeks and I have not seen any results at all.”
But, a different customer revealed, “Did the research and haven’t found where anyone lost weight.”
As is the case most of the time, there are positive reviews of Sinetrol.
Another posted, “I read that it offers antioxidant support, so that’s a good thing.” 
The research we’ve conducted has revealed that if there’s a certain aspect of a weight-loss ingredient or diet product that is quite difficult or bothersome (minimal results, discouraging user comments, side effects) the likelihood of long-term success is slim. Therefore, if Sinetrol does fail to produce real effects in a lot of people, this could be a major dilemma.
The Science – “Find Any Evidence?”
We at DietSpotlight look for solid science used to support any applicable weight-loss claims. Regarding Sinetrol, there are studies relating to the use of citrus extracts and improved cardiovascular health, fat loss and burning.  The only concern was the amount and the time-frame to see results. While we like that there are some studies, the results are mixed.
The Bottom Line – Does Sinetrol Work?
Will Sinetrol help you lose weight? Well, we like that it contains natural ingredients and that there are some studies relating to efficacy, but the lack of concrete evidence showing users will burn fat and improve long-term weight-loss leaves us concerned . There’s also the issue of consumers no seeing results and the presence of discouraging reviews.
If your’re looking to lose those extra pounds, we suggest going with a product containing ingredients backed by science and connected to positive dieter reviews.
Among the best products we’ve seen this year is one called Leptigen. The supplement contains four clinically-tested ingredients, which have been shown to help boost fat loss and elevate metabolism. There’s no mention of harmful side effects and users are talking about seeing great results.
The makers of Leptigen are so confident in their product, that they’re offering customers a Special Trial Offer.
Previous Sinetrol Review (Updated December 29, 2011):
What You Should Know about SinetrolSinetrol is more likely to be added to other weight loss supplements than found for sale as a standalone product. Created by NB Consulting, a French company, Sinetrol is a fat burning ingredient that can be purchased by supplement companies for use in their products. Sinetrol is derived from fruits and claims to be a 100% food product. There are no stimulants in the fat burning ingredient, which is uncommon for a fat burner. When searching for Sinetrol, we could not find any product listing this ingredient. Information on the official website was last updated in 2008.
List of Sinetrol IngredientsExtracts of red orange, grapefruit and citrus.
Product FeaturesSinetrol is a relatively unknown ingredient in the weight loss world. The ingredient claims to have fat burning potential, but there are no stimulants to increase heart rate. Stimulants are commonly used as fat burners because increased heart rate leads to calorie deficit which means the body will burn more calories stored as fat. If Sinetrol does have fat burning capabilities, they would not reside in this theory. Interestingly enough, the name Sinetrol is not far off from synephrine. Synephrine is derived from the bitter orange tree and is a fat burning ingredient in many weight loss products. Synephrine is a stimulant, however, and in some cases can cause health issues in dieters who use the product for extended periods of time. Whether Sinetrol and synephrine is the same product, we cannot be sure. The Sinetrol website offers no information on the exact make-up of the ingredient. No products are listed that contain the ingredient either. What is offered is a list of product companies that offer Sinetrol for sale. None of these companies are based in the United States and none currently sell weight loss supplements containing the ingredient. There is no pricing information available for Sinetrol as it cannot be purchased by an individual for home use.
Advantages of Sinetrol
- All natural sources.
- The official website offers a list of retailers selling Sinetrol.
Disadvantages of Sinetrol
- There are no known weight loss supplements using the ingredient.
- Sinetrol may be a brand name for synephrine.
- Sinetrol cannot be purchased by dieters directly.
- The official website was updated more than two years ago.
ConclusionIf Sinetrol was a good fat burning ingredient, weight loss companies would not need to include stimulants in their formulas. There is no known way of increasing fat burn without increasing heart rate. Stimulants increase heart rate and Sinetrol does not contain any stimulants. Dieters wanting to try Sinetrol to increase fat burn may have difficulty locating a supplement using the ingredient. We could find no supplements listing Sinetrol on their ingredient lists and the official website offers no leads in this regard.
Sinetrol Questions & Answers:
We sorted through hundreds of user comments about Sinetrol to form this helpful FAQ.
What are the side effects of Sinetrol?
Sinetrol side effects may include a slight boost in energy, based on user comments.
What are the ingredients in Sinetrol?
Sinetrol ingredients are sweet orange, blood orange, and grapefruit extracts.
Does Sinetrol work?
There’s a wealth of information presented on the official Sinetrol website about the benefits of the extract. We found several studies showing users noticed decreases in abdominal fat, body weight and waist and hip circumference.  We also located research where it was shown to help boost skeletal metabolism ; but only during the 12-week trial.
How much does Sinetrol cost?
On Amazon, a box of 90 capsules is $4.99.
How should I take Sinetrol?
As said on the label, you should take two capsules, twice a day with a full glass of water 30 minutes before your meal.
Can I take Sinetrol if I have a health condition?
Before taking supplements such as Sinetrol, you should talk to your physician if you have heal problems, if you are pregnant, nursing, under the age of 18, or taking other prescriptions.
What do users like about Sinetrol?
Users taking Sinetrol said they experienced a loss in appetite and increase in energy.
What do users NOT like about Sinetrol?
There weren’t many negative comments about Sinetrol.
How do I contact Sinetrol customer service?
You can contact the customer service of Sinetrol by going to their contact us page in their official website, calling the corporate headquarters at 1-973-204-0460 or by mailing letters to Fytexia Corp. c/o Pramex International Corp. 1251 Avenue of the Americas New York, New York 10020.
Does Sinetrol come with a guarantee?
There was no guarantee on the official website.
Can I take Sinetrol with other fat burners?
We would recommend you talk to your physician before taking Sinetrol with other fat burners.
Do you know of any special deals or discounts on Sinetrol?
We weren’t able to find any special deals or discounts on Sinetrol. However, our readers have been going wild over the last several months taking advantage of the Special Trial Offer from Leptigen. To learn more about it, click above.
- 1. Clinical study to assess the efficacy and safety of a citrus polyphenolic extract of red orange, grapefruit, and orange (Sinetrol-XPur) on weight management and metabolic parameters in healthy overweight individuals (2014). Phytotherapy Research. December 8, 2016.
- 2. A 12-week randomized double-blind parallel pilot trial of Sinetrol XPur on body weight, abdominal fat, waist circumference, and muscle metabolism in overweight men (2015). International Journal of Food Sciences and Nutrition. December 8, 2016.
Sinetrol User Tips:
7 Top User Tips
Over the years, we’ve come to realize that people using products that contain Sinetrol have something to say. After consulting thousands of reviews and user comments, we collected these tips to help you learn more about this ingredient.
“T was looking for a boost to help me lose some extra pounds. It took two months to see any results.” Jenn
“I take it before I go to bed to help me with late night snacks.” Bibi
“I felt very ‘speedy’ especially at night when I began to sweat from this product so I only take it during the day.” Marty
“I suggest taking this with plenty of water.” Sherry
“You have to follow a diet plan if you want to see results.” Lisa
“If you’re willing to commit to something and exercise and eat right if you add these pills think that they will help you burn off the fat.” Sabrina
“You still need to exercise and watch what you’re putting in your body if you want to see results.” Cyrus
Sinetrol Scientific Abstracts:
Sinetrol is known to have 2.1 more activity than guarana 12% caffeine all while possessing 3 times less the amount of caffeine. There were two groups of participants (10 individuals in each group) with a body mass index high enough to be considered overweight were observed throughout a 4 and 12 week study where they ingested 1.4 g per day Sinetrol as well as placebo. Participants in the Sinetrol group experienced a decrease of body fat percentage with a substantial difference of 5.53% and 15.6% respectively, following the 4 and 12 weeks. Body weight of the participants reduced with a large difference (2.2 and 5.2 kg respectively) following the 4th and the 12th week. The effects of weight-loss were attributed to Sinetrol polyphenolic composition and its synergistic activity. Sinetrol was found to be a powerful trigger of PDE (cAMP- phosphodiesterase) at 97% in comparison to narangin , cyanidin-3 glycoside and caffeine. In conclusion, it has been indicated that that Sinetrol contains powerful lipolytic properties which are controlled by cAMP-PDE inhibition. Sinetrol was found to prevent obesity by reducing body mass index. 
A randomized, controlled, double-blind study was carried out for a period of 12 weeks. Sinetrol-XPur was administered to overweight participants two times per day along with each meal in one group (N=47) compared to a placebo group (N=48). Hip and waist circumference along with belly fat were reduced in the tested group in comparison to the placebo group (p < 0.0001) (-5.71% versus -1.56% for waist circumference, -4.71% versus -1.35% for hip circumference and -9.73% versus -3.18% for fat). Inflammatory markers were then noticed to decrease. There was a notable reduction of oxidative stress as noticed by the decrease of malondialdehyde (-14.03% versus 2.76%) as well as an elevation of glutathione and superoxide dismutase (4.63% versus -2.36% and 17.38% versus 2.19%, p < 0.01). There were no adverse reactions noticed within the study. Results suggest Sinetrol-XPur is a useful tool for decreasing abdominal fat and reducing waist and hip circumference while enhancing inflammatory and oxidative status in overweight human subjects. 
Overweight male participants in a randomized, double-blind trial were observed following consumption of 900 mg citrus-based polyphenol extract (Sinetrol XPur) per day for 12 weeks. Before and following the intervention period, body composition, blood and anthropometric parameters were closely observed. Following the 12 weeks, metabolic framework was substantially improved with a suppression of skeletal muscle catabolism. The results of the trial indicate that over a 12 week period of time, the effectiveness of the Sinetrol XPur supplement correlated skeletal muscle mass metabolism and improved both overweight process. 
- 1. . Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE) (2008). International Journal of Phytotherapy and Phytopharmacology. December 7, 2016.
- 2. . Clinical study to assess the efficacy and safety of a citrus polyphenolic extract of red orange, grapefruit, and orange (Sinetrol-XPur) on weight management and metabolic parameters in healthy overweight individuals (2014). Phytotherapy Research. December 7, 2016.
- 3. A 12-week randomized double-blind parallel pilot trial of Sinetrol XPur on body weight, abdominal fat, waist circumference, and muscle metabolism in overweight men (2015). International Journal of Food Sciences and Nutrition. December 7, 2016.
Sinetrol Side Effects:
Side effects are one of the top factors to take into consideration when deciding on a new weight loss supplement. If a product causes negative effects, it could negatively impact your health and ultimately prove ineffective. Although Sinetrol checks out with good remarks from most users, there are a few side effects you should know about.
A case of “the runs” is no fun. It’s painful, uncomfortable, and inconvenient. You have to run to the bathroom every few minutes. The constant bowel movement leaves you dehydrated and sore. If you have diarrhea, you likely also have stomach pain and cramps.
What causes diarrhea?
Diarrhea occurs when something is messing with your stomach. It may be you ate something that didn’t sit well with you, such as spoiled food or a dish to which you have an intolerance/allergy. Common conditions known to causes diarrhea include viruses, bacteria, and digestive disorders like irritable bowel syndrome .
Rapid Heart Rate
Also known as tachycardia, rapid heart rate is when your heart beats too fast. The reason this is bad is because a rapid heart rate keeps your body from getting enough blood. As a result, your tissues and organs suffer. Usually, you can even feel the excessively fast beating of your heart. Dizziness, light-headedness, shortness of breath, and chest pain are all symptoms of rapid heart rate.
What causes rapid heart rate?
Tachycardia is a result of interruption to your heart’s electrical impulses. High blood pressure, tissue damage, alcohol abuse, overactive thyroid, and fever are factors that contribute to rapid heart rate.
Many conditions cause nervousness and anxiety. You feel stressed, on-edge, and easily irritable. You might experience jittering and shaking.
What causes nervousness?
Nervousness is often the result of emotional and social pressures. However, it may stem from underlying medical conditions. In some instances, nervousness is a sign of heart disease, diabetes, thyroid problems, irritable bowel syndrome, and hormone disorders .
Heart palpitations, or bounding pulse, is a condition in which your heart beats harder than it should. It can feel as though your heart is skipping beats or going too fast.
What causes palpitations?
Palpitations isn’t always a bad omen. Nervousness and exercise are everyday factors that can make your heart beat harder than normal. It’s cause for concern if your palpitations are accompanied by chest pain, fainting, or shortness of breath. In this case, you may be suffering from tachycardia, abnormal heart rhythm, or hyperthyroidism. Although some people have experienced side effects using Sinetrol, that doesn’t necessarily mean you will. Everyone’s body reacts differently to supplements. To be safe, talk with your doctor about whether this product is right for you.
Sinetrol Ingredients and Supplement Facts
Serving Per Container:
|Amount per Serving||% DV|
Other Ingredients: None
We looked into Sinetrol ingredients so we could give you the information you want.
Blood Orange Extract
This extract is derived from the blood orange fruit. The liquid is often used to flavor bakery goods. However, some companies have determined the compound to be beneficial for general health, which is why it can be found in some herbal supplements and medications.
What is it Supposed to Do?
The blood orange fruit contains anthocyanin, vitamin C, dietary fiber, folate, calcium, and thiamine, all of which are essential to the diet and can promote well-being and overall health when consumed in the right amounts. Anthocyanin is considered an antioxidant, which can prove to be beneficial to health as well.
According to research published in the International Journal of Obesity, blood orange could slow fat accumulation in mice. However, the conclusion derived from this study is not supported by other research studies.
Grapefruit extract stems from the pulp and seeds of the citrus fruit. It contains compounds like vitamin C, pectin, potassium, and fiber.
What is it Supposed to Do?
Grapefruit extract is consumed to treat various ailments, including different kinds of infections. It is also an important component in natural pesticides, soaps, cosmetics, cleaners, first-aid treatments, and mouthwash.
A study published in the Journal of Alternative and Complementary Medicine (New York, N.Y.) found that grapefruit extract was effective as an antibacterial agent in humans, something that may be beneficial those wanting more natural treatment options .
Sweet Orange Extract
The sweet orange extract is derived from its juice and peel. The compound contains significant amounts of vitamin C and potassium, which may be the reason it is proposed to have many health benefits for the body.
What is it Supposed to Do?
When consumed medically, the sweet orange extract is used to treat acid indigestion, colds, kidney stones, high blood pressure, high appetite, high cholesterol, and even cancer.
Unfortunately, a significant amount of research testing the effects of sweet orange extract does not exist. However, one study published in Animal Science Journal found that the compound may have a beneficial effect on the immune response for broiler chickens. Another study, published in Molecular Nutrition and Food Research, found that certain chemicals within the extract may potentially play a role in lung cancer prevention in humans .
We’ve been keeping an eye on a product that offers four clinically tested ingredients; Leptigen.
- 1. The effectiveness of processed grapefruit-seed extract as an antibacterial agent: II. Mechanism of action and in vitro toxicity. (2002). Journal of Alternative and Complementary Medicine. January 11, 2017.
- 2. Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel inhibit growth of human lung cancer cells by apoptosis. (2009). Molecular Nutrition and Food Research. January 11, 2017.