Updated: 04/18/2017 - Site operated by Leptigen

Cissus Review - Does This Ingredient Really Work?

  • 5 User Comments
  • Rating: 3.0. From 3 votes.
By Summer Banks Mar 16, 2017

Give me two minutes of your time and I’ll give you all the details on Cissus. We focused this review closely on ingredients, side effects, scientific studies, and customer-service quality. Then we examined various user comments from all over the internet. Finally, we narrowed down all of the information we collected to give you the bottom line.

Cissus Readers: Click here to find out why we're giving away samples of our product, Leptigen.

What is Cissus?

To begin with, Cissus is cissus quadrangularis; a plant in the grape family. It is a commonly used in a medicinal nature in a number of countries, including Thailand, Africa, and India. The ingredients found in the supplements can vary, but you can buy it as a standalone product.

There is no one company to credit for Cissus. You can find a version on retail websites and in vitamin stores. We like that it is all-natural and the price is amazing, but read on…

Side Effects – “Unpleasant?”

The first issue are the potential Cissus side effects. Some of the most common are headache, gastrointestinal discomfort, insomnia, dry mouth, and diarrhea. According to our Research Editor, “If reactions are bothersome enough, even if it is a placebo effect, most consumers will discontinue the use of a product no matter how well it works.”

One dissatisfied customer quipped, “I got the worst headaches ever every time I took this. I couldn’t handle it.”

Another complained, “I don’t usually have trouble sleeping but while I was taking this I hardly slept at all. That sounds great in theory but I was so tired I couldn’t get anything done.”

Some users didn’t experience any substantial negative side effects.

According to one, “My stomach was a little upset the first few days I was taking this but then it went away.”

A happy dieter said, “This worked great and I didn’t notice any side effects at all.”

Limited Evidence– “Not Primarily for Weight-Loss”

There is some evidence that Cissus quadrangularis is effective in the treatment of mending broken bones and alleviating arthritis symptoms. However, the transition into the weight-loss market is not well supported by research.

A worried customer said, “I was excited about using something so common in traditional medicine. Then I realized it’s historically been used to treat something entirely different.”

While another noted that, “There is almost no research that’s been done in the United States. That bothered me a lot.”

Some people are less worried with more contemporary studies.

One happy client explained, “I’ve had great luck with it and that’s all that really matters to me.”

Echoed by another who said, “It must be safe if it’s been used for so long and it helps me lose weight. I don’t care if science hasn’t caught up yet.”

According to our research, side effects and limited research can really hinder any chance of lasting success. If Cissus causes negative issues or it isn’t working as expected, that’s a big red flag.

The Science – “No Verifiable Support?”

At DietSpotlight, we need to know that the science is there to back up the claims of a company. With Cissus that doesn’t appear to be true. While there are some studies that indicate it can be beneficial in the treatment of arthritis, weight-loss support just isn’t the main focus.

The Bottom Line – Does Cissus Work?

Should I race out for a bottle of Cissus? If you want to give it a try for the potential boost to muscle tone it could help. Unfortunately, there are no direct links to weight-loss which is why we have reservations about giving it our endorsement. There’s also the fact that some users experienced side effects, which is never a good thing.

If you want to drop those extra pounds, why not try a supplement with ingredients that are backed by scientific research. A truly great product will help you lose weight safely. It will also be backed by a strong customer service department that can help answer any questions you may have.

Among the best products we have seen this year is called Leptigen. It is made of four active ingredients that have been demonstrated in clinical research settings to help boost fat loss and enhance metabolism. Our in depth review process didn’t turn up any negative user comments. What we did find was a lot of happy customers sharing their success stories.

The makers of Leptigen are so sure of their product they’re offering a Special Trial Offer, which is something we like to see.

Previous Cissus Review (Updated September 20, 2013):

What You Should Know

Cissus quadrangularis is a medicinal plant that comes from India, and has traditionally been used for healing fractures. It is now used in many supplements for people who wish to aid recovery after injury or who wish to improve the general health of their joints, muscles, cartilage and tendons. This ingredient has become popular with athletes and anyone interested in sports. Supplements making use of cissus are sold by many different brands, though the product is usually a single extract of cissus, rather than combining this with several other ingredients. In fact, the plant itself contains a unique blend of vitamins and minerals that have been shown scientifically to be able to strengthen bone tissue. Cissus contains vitamin C and calcium among other ingredients. Manufacturers claim that the product helps to deliver nutrients to injured areas in order to speed up the body's own repair process, as well as influencing the early regeneration of connective tissue.


Vitamin C, carotene A, anabolic steroidal substances and calcium. Ingredients may vary according to the specific producer of the cissus product.

Product Features

Cissus is not sold as a product that can cure any disease or guarantee to heal injuries but instead is sold as a supplement that can have a positive impact on general health. Anyone who participates in intense physical activity, including athletes, can benefit from using this natural supplement due to the fact that it can help improve the condition of bones. Many companies are also claiming that it can improve the state of muscles which is hard to judge as little scientific evidence is given for this use. The ingredients state that it includes steroidal substances but do not expand on this blanket term. There are user testimonials available about these products after a quick search on the Internet. Many users claimed that it helped them get into their usual workout routine, and even to become leaner and stronger. It's these testimonials along with private scientific studies that help put this ingredient into the "diet" category.


  • Scientific studies show that this ingredient does have some benefits for weight loss and blood sugar levels.


  • Cissus is primarily used in arthritis products and for bone treatments.
  • Not many products use cissus as a main ingredient.
  • The scientific studies done on Cissus were conducted privately in Cameroon.


Cissus is a rather unique plant ingredient that has been used to heal fractured bones and help with arthritis for centuries. Only recently has this ingredient been touted as a weight loss product so we aren't sure of its effectiveness. Some common products that contain cissus are Cylaris and CardioTrim which both have mixed reviews. While it couldn't hurt to have cissus in your weight loss products, we wouldn't suggest that you take a large quantity of it in a standalone supplement.
Get Your Sample Today »
Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Leptigen, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 3.0. From 3 votes.
Please wait...
Cissus Review

How Does Cissus Compare?

User Comments

5 Comments on "Cissus Review"


Sort by:   newest | oldest | most voted
angelie grace

what is the desease it can cure?

pradeep pawar

Is cissus safe for patient suffering from renal calculi.


Is Cissus legal in the NFL?


What does this site think of “Supercissus RX”? You guys mentioned 2 other cissus products but wondering if you guys have any words for this one? I’ve tried it once and would like to get another bottle.