Memory supplements and brain supplements hit the market like wildfire. But, do they work? That’s the question everyone wants answered. So, you may be surprised by what I say in this Prevagen review. We keep hearing about the active ingredient in Prevagen called apoaequorin. However, we’ll also take a closer look at the Prevagen side effects and research backing the formula. After reading hundreds of user comments and testimonials, we summarized the facts for you.
What is Prevagen?
First off, Prevagen is an herbal remedy product for brain and memory health which prevent memory loss and improve concentration. This brain supplement is produced by the Quincy Bioscience company.
According to its manufacturer, Prevagen consisted of a protein from jellyfish called apoaequorin, which promotes and enhances brain function.
This protein supposedly reduces excess calcium levels in the brain and improve short-term memory problems. It also contains vitamin D.
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How Did Prevagen Start?
Prevagen contains apoaequorin, a protein that was originally discovered in the Aequorea Victoria jellyfish.
According to WebMed, “Problems with calcium regulation in the human brain are thought to play a role in age-related mental decline. Because apoaequorin has a similar structure to human calcium-binding proteins, some researchers believe it might help regulate calcium in the brain and reduce memory loss and mental decline” 
Prevagen claims to improve the health and function of the brain. According to PubMed, “Pharmacological manipulation of the entry of free calcium (Ca2+) has been shown to be effective in increasing some aspects of cognitive function in the aged brain. Apoaequorin has been shown in laboratory studies to regulate levels of intracellular calcium in neuronal cells and to provide protection against ischemic cell death.” 
Research shows that consuming 10 Mg of Prevagen per day for 90 days will improve mental quality of older adults. Other research suggests that consuming 20 mg Prevagen 2 or 3 hours after wake up and 30-60 mg, 30 min before bed along with other drugs will reduce the progression of ALS.
Prevagen contains the following ingredients:
- White Rice Flour
- Sodium Chloride
- Magnesium Stearate
- Acetic Acid
A serving size of Prevagen is equal to 1 capsule, and 30 servings come in a container of the supplement. There is 20 mg of apoaequorin in every serving.
Does Prevagen Work?
Apoaequorin is an important protein in Prevagen meant to improve the function of the brain. Some research suggests this ingredient helps in cases with mild health problems, with still little to no effect on them.
Its company claimed that it enters the brain to supplement proteins lost during the aging process. However,
“According to the FTC and New York AG, the defendants don’t have studies showing that apoaequorin taken orally ever reaches the brain: ‘To the contrary, Defendants’ safety studies show that apoaequorin is rapidly digested in the stomach and broken down into amino acids and small peptides like any other dietary protein.'”
Prevagen Benefits and Results
Prevagen may be a good product for mild health problems, particularly ones due to aging. It may be suitable for adults want to improve short-term memory overall brain health.
It also contains no stimulants, unlike other brain supplements.
Prevagen contains no allergens and is easy to take. It includes a money back guarantee in 30 days.
Berkley wellness claimed that:
“The primary ingredient in Prevagen is a synthetic version of apoaequorin, a protein originally derived from certain jellyfish. The Prevagen researchers hypothesize that, by regulating levels of intracellular calcium, “apoaequorin has the potential to improve the function of aging neurons and, therefore, to enhance memory and cognitive function.” This is scientifically implausible.
Even if this hypothesis were true, as the FTC points out, the company’s own “safety studies show that apoaequorin is rapidly digested in the stomach and broken down into amino acids and small peptides like any other dietary protein.” And even if the orally consumed protein somehow got into the bloodstream, there’s no evidence that it can cross the human blood-brain barrier to affect neurons.”
How to Use (Take) Prevagen
For improvement in memory, commonly resulted by aging, 90 days regular use of this supplement is recommended. According to WebMed,
“The appropriate dose of apoaequorin depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for apoaequorin (in children/in adults).
Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.” 
If you want to use Prevagen with other medications, we aren’t aware of any negative interactions; but it’s better to talk with your doctor before beginning Prevagen use.
Potential Prevagen Side Effects
The side effects reported by Some people in the first few weeks of using Prevagen, including headaches, itching, dizziness, diarrhea, and increased blood pressure. According to PubMed,
“Apoaequorin is POSSIBLY SAFE when taken by mouth appropriately. A 10 mg dose of a specific apoaequorin product (Prevagen, Quincy Bioscience) has been used safely for up to 90 days. No clinical research has adequately evaluated side effects caused by apoaequorin. Some people who have taken apoaequorin have reported potential side effects to a manufacturer of the product. Some of the most commonly reported side effects were headache, dizziness, and nausea.
Others less common events were memory problems, difficulty sleeping, and anxiety. There have also been a smaller number of reports of more serious potential side effects such as heart and nervous system-related events. It is important to understand that although these events occurred while people took this product, this does not necessarily mean that the product caused these events. There is not enough information about these potential side effects to know if apoaequorin was the actual cause of these side effects” 
Warnings about Prevagen
The FDA has run into trouble with Prevagen before. They accused the supplement company of not reporting some serious side effects, like fainting, chest pain, and even seizures.
Apparently, Prevagen received more than 1,000 reports concerning these effects between 2008 and 2011, but only reported 2.
It’s easy to say that Prevagen isn’t FDA approved.
Unfortunately, the website concealed side effects that may occur as a result of the treatment. The supporting studies described on the website were very limited, and are not independently verified. The evidence supporting the supplement is not quantitative either.
There are a lot of brain products, and Lumonol Wisdom is one of them. Lumonol Wisdom is a new product created by Avanse Nutraceuticals.
This product contains Noonpet, a compound claiming to provide a variety of benefits including:
- Improved Memory Recall
- Increased Memory Capacity
- Improved Learning Skills
- Increased Processing Speed
- Enhanced Mood
Noopept in Lumonol acts in three different ways to affect the brain. First, it affects two brain receptors, NMDA and AMPA, which are effective factors in the human learning process.
Second, it is supposed to influence the nerve growth factor and brain neurotrophic factor, both of which are essential elements in the health and vitality of neurons.
Third, it apparently increases acetylcholine in the brain, the neurotransmitters that help humans learning and retain memories. This might make it a good alternative for Prevagen.
Prevagen isn’t cheap, but if you order direct from the company, a month’s supply of pills will cost you $66 with shipping. It’s also available on Amazon, eBay, Walgreen websites.
However, before buying, there are some alternatives you should consider.
Prevagen Extra Strength
Prevagen Extra Strength is just a stronger version of the original formula. It claims to be an advanced “brain enhancement supplement,” saying it can:
- Increase Mental Function
- Promote Clearer Thinking
- Improve Overall Brain Health
One bottle, or a month’s supply, can be purchased both from the official website and third-party retailers. Money back guarantees will depend on the policies of those you purchased it from.
Prevagen Extra Strength claims that, with continuous use, the user will experience a sharp mind, improved memory, and increased concentration. The supplement also contains no common allergens or artificial stimulants.
Just like the original formula, Prevagen Extra Strength’s main ingredient is apoaequorin.
Prevagen vs. Focus Factor
Indeed, Focus Factor is like a typical multivitamin, and it has long and complicated list of ingredients, but this product improves mind and memory.
The ingredient list in Focus Factor mainly consists of a wide variety of vitamins, micronutrients, and minerals, as well as some fruit extracts and natural herbs. One of the main concerns with this brain supplement, though, is its lengthy ingredient list.
Although there have been no reports of any significant side effects of the supplement, in some cases, the use of Focus Factor can lead to gastric upset.
Prevagen vs. Alpha Brain
Alpha Brain is another brain supplement rivaling Prevagen. This product focuses on boosting concentration, memory, and energy, making it popular with executives and college students. Ingredients in this one include:
- Alpha GPC
- Huperzine A
The company behind Alpha Brain claim its ingredients are responsible for its claimed benefits. It costs about $26 on Amazon.
What Users Are Saying
“I am a senior citizen and have been using this product for months with great results.”
“Appears to help some with recent memory, hard to quantitate.”
“I took this for several months…probably four. or five. I have chemo brain and thought it would improve my short term memory loss. I really didn’t notice any improvement.”
The Bottom Line – Does Prevagen Work?
So, should you race out to buy Prevagen? Well, we like that Prevagen is easy to find and that we found, but the research not pointing toward weight-loss leaves us concerned. Furthermore, we have some issues with the numerous customer complaints, especially relating to adverse effects.
Do you want to lose weight and improve wellness? Consider combining Prevagen with a supplement containing clinically-tested ingredients shown to help with weight-loss.
Among the best products we’ve seen this year is one called Burn HD. This supplement contains clinically-tested ingredients, which have been shown to help boost metabolism and accelerate fat loss. We have not found any talk of harmful side effects and user comments indicate people are seeing substantial results.
The makers of Burn HD are so confident in their product they’re offering a 2-Week Sample, which is a good sign.
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