Updated: 01/10/2017 - Site operated by Leptigen
By Summer Banks Dec 19, 2016
108comments

You may be surprised by what I say in this Prevagen review. We at DietSpotlight dug deep into the ingredients, side effects, and scientific studies. Plus, we took a close look at hundreds of customer comments. Then, we summarized the facts to give you the info you need.

Prevagen Readers: Click here to find out why we're giving away samples of our product, Leptigen.

What is Prevagen?

First off, Prevagen is an over-the-counter dietary supplement containing the active ingredient Apoaequorin. [1] Take one each morning and it supposedly improves memory, promotes clearer thinking and a sharper mind. [2] The product doesn’t contain synthetics – impressive.

Prevagen was first introduced in 2007 by Quincy Bioscience.[3] Although it’s not sold on the official website, several trusted retailers have it on the shelves. We like the longevity of the company and that we located some favorable customer comments, but read on…

Prevagen Side Effects – “Concerning?”

The first thing that concerned us were reports of Prevagen side effects. [4] “We read one review after another with claims of negative reactions,” says our Research Editor. “That’s not what the customer is looking for.”

One user complained, “Developed heart flutter about 75 days after I started taking this.”

“Upon taking my first Prevagen, within a half hour I became light headed and dizzy and my focus was worse than ever the rest of the day,” commented one user.

Another person said, “I don’t have high blood pressure and it made my blood pressure go up.”

User Complaints – “Another Concern”

Numerous customer complaints are posted online concerning Prevagen. One user stated, “I had a reversal of memory while taking this product. Many instances where I forgot peoples’ names in public situations.”

Another customer said, “I took the Prevagen 10mg pills for 30 days and I honestly don’t notice any difference. Don’t waste your money on this.”

There are some users who saw positive results.

“The change was subtle to begin with but has suddenly became more noticeable by the 4th month,” said one person.

Some felt the results were good, but the price was a little over the top.

I have taken this product with positive results but I think it is too expensive,” offered up one user.

The extensive research we’ve done has revealed if there is a particular facet of a dietary supplement that’s concerning, such as too many user complaint, the probability of long-term success is low. If Prevagen does cause reactions in users, this could be a serious problem.

The Science – “Is it Legit?”

There are some studies presented on the official website that pertain to Apoaequorin, the active ingredient in Prevagen. While this is good to see, there’s no proof this product relates to weight-loss. Also, the FDA had to issue a warning about this product because it can lead to side effects. [5] At DietSpotlight, research is imperative. If the science doesn’t back the claims or support you losing weight, we raise the red flag.

The Bottom Line – Does Prevagen Work?

So, should you race out to buy Prevagen? Well, we like that Prevagen is easy to find and that we found, but the research not pointing toward weight-loss leaves us concerned. [6] Furthermore, we have some issues with the numerous customer complaints, especially relating to adverse effects. [7] [8] [9]

Do you want to lose weight and improve wellness? Consider combining Prevagen with a supplement containing clinically-tested ingredients shown to help with weight-loss.

Among the best products we’ve seen this year is one called Leptigen. This supplement contains clinically-tested ingredients, which have been shown to help boost metabolism and accelerate fat loss. We have not found any talk of harmful side effects and user comments indicate people are seeing substantial results.

The makers of Leptigen are so confident in their product they’re offering a Special Trial Offer, which is a good sign.

Previous Prevagen Review (Updated June 16, 2014):

What You Should Know about Prevagen

The brain protects its cells from degradation by generating a protein that regulates cellular calcium. If calcium increases in cells, they will be destroyed. With the natural aging process, the body generates that protein in lesser amounts. Prevagen is a supplement that promotes the better health of the brain and its functions, in much the same way Focus Factor does. The product focuses on improving memory loss and protecting the brain by supplying it with a protein called apoaequorin. This protein belongs to a family of molecules that binds calcium. Prevagen can easily be bought from health food stores as well Rite Aid stores. However, the website’s online shopping page allows interested clientele to purchase the amount they want.

List of Prevagen Ingredients

The only ingredient that is mentioned on the website is the apoaequorin protein, which is extracted from jellyfish. Even the concentration of that protein isn’t mentioned in the Prevagen material.

Product Features

Prevagen claims to bind calcium in cells, thus reducing the damage which occurs when the body doesn’t produce many calcium binding proteins as it ages. Prevagen, like Vibra Slim, is designed for people 40 and older. The apoaequorin protein, which was discovered in the early sixties, is apparently responsible for the whole calcium binding process. Prevagen, along with Ambislim PM, also promotes restful sleep. This effect is a double-sided coin, as we discuss on our Prevagen Side Effects review The research conducted by the supplement’s developers supposedly demonstrated that the apoaequorin protein mainly benefits consumers by enhancing their mental clarity, honing their decision-making skills, improving their memory and helping them focus. This affect on the brain is similar to how the leptin in Leptinal impedes the hunger signals in your brain. However, these claims haven’t been confirmed by the FDA. Still, the website promises consumers positive results between periods of use from 30 and 90 days. Aside from that, the product has been approved to be kosher by two of the four main production facilities in the United States.

Advantages of Prevagen

  • The website does offer supporting evidence regarding Prevagen’s effects on memory and sleep.
  • An informative video explains how the supplements will enhance the brain’s functionalities.
  • The website directly states that it hasn’t been FDA approved, thus spares consumers the time and effort of trying to locate the FDA approval stamp.

Disadvantages of Prevagen

  • The product isn’t FDA approved. Although the website was truthful enough to mention this fact, it still isn’t a favorable factor.
  • There are no indications regarding Prevagen being free from side effects.
  • The supporting studies were limited studies, not full-scale ones.
  • The evidence supporting the product is mainly anecdotal and not quantitative.

Conclusion

Age does affect the body in various ways, and the brain is no exception. Age has a very taxing affect on the body and mind; numerous products including Nature's Pearl try to tackle this. If Prevagen is really as good as it claims to be, people will really benefit immensely. However, with the supplement’s shortcomings, caution should be taken prior to its consumption.

Prevagen Questions & Answers:

We summarized hundreds of user comments about Prevagen into this helpful FAQ.

What are the side effects of Prev?

Prev, yes we mean Prevagen. Some potential side effects of Prevagen include heart arrhythmia [1], fainting, tremors and chest pains; based on customer reviews.

What is in Prevagen?

Prevagen ingredients are apoaequorin [2], white rice flour, sodium chloride, magnesium stearate and acetic acid.

What is the active ingredient in Prevagen?

The active ingredient in Prevagen is apoaequorin.

Does Prevagen work?

There is scientific research proving Prevagen is effective for improving memory. Unfortunately, there’s no studies linking the ingredients to weight-loss.

How much does a bottle of Prevagen cost?

A bottle of Prevagen costs $59.95. If you buy two bottles, the price increases to $119.90. Three runs $239.80 and eight is $479.60. You receive a discount on multiple bottle purchases.

How do you take Prev?

You take one Prevagen capsule in the morning with or without food. One bottle lasts 30 days.

Can I take Prevagen if I have a health condition?

Woman who are pregnant or nursing, anyone taking prescription medications, people with health conditions or anyone under 18 years of age should consult a healthcare provider prior to using any supplement, including Prevagen.

What do users like about Prevagen?

Some users like the affordability of Prevagen and that they receive a discount on multiple bottle purchases.

What do users NOT like about Prevagen?

We found that some Prev users don’t like the side effects associated with the supplement.

Who makes Prevagen?

Quincy Bioscience makes Prevagen.

How do I contact the Prevagen customer service department?

You can contact the Prevagen customer service department by mailing correspondence to Quincy Bioscience 301 S. Westfield Rd. Madison, WI 53717, emailing a representative at customerservice@prevagen.com or calling 1- 855-331-7721.

Can I contact Prevagen through social media?

Yes, you can contact Prevagen through Facebook and Twitter.

What is the main ingredient in Prev?

The main ingredient in Prevagen is apoaequorin. This is found in certain species of jellyfish.

Do I have to diet and exercise on Prevagen?

No, you don’t have to diet or exercise on Prevagen, but the official website recommends adding healthy eating and fitness to any supplementation.

Can I purchase Prevagen at local stores?

Yes, you can purchase Prevagen at local retailers. You may not receive the multiple bottle discounts.

Has the Food and Drug Administration contacted the makers of Prevagen?

Yes, the FDA sent letters to Quincy Bioscience Manufacturing relating to mislabeling of the supplement and claims made by the company.

Is there a guarantee with Prevagen?

Yes, there’s a guarantee with Prev. You can return any portion of the supplement for a complete refund of your money within 30 days.

Do you know of any special deals or discounts on Prevagen?

The only discounts and special deals on Prevagen include savings if you order multiple bottles. However, our readers have been going wild over the past few months taking advantage of the Special Trial Offer from Leptigen. Click above to learn more.

Prevagen Scientific Abstracts:

Apoaequorin

Neurons from OGD were dose-dependently shielded by apoaequorin. At doses of 1% and 4%, there was a significant reduction in number of trypan blue-labeled neurons. This time dependent effect lasted 48 hours. This effect had been mirrored by alterations in chemokine and cytokine expression, suggesting that apoaequorin could shield neurons through a neuroimmunomodulatory mechanism. This data reveals that pretreatments with apoaequorin will indeed protect neurons from ischemic cell death, and could be an effective neurotherapeutic. [1]

The study was put into place to discover if there had been adverse effects to apoaequorin in rats, after subchronic administration. The results had shown NOAEL (No Observed-Adverse-Effect Level) for apoaequorin was at 666.7 mg/kg bw/day tested at the highest dose. There had not been any mortality resulting from administration of apoaequorin. There had been no signs of body weight gain, food efficiency, food consumption, histopathological, or clinical pathology differences which could point toward apoaequorin administration. [2]

White Rice

Data was compiled from perspective and cohort studies showing the Asian populations having much higher rice ingestion levels than the West (average intake was three to four servings per day vs. one to two servings per week). Pooled relative risk was at 1.55 (95% CI 1.20 to 2.01) when weighing the highest and the lowest white rice consumption in Asian populations, and the comparable relative risk was at 1.12 (0.94 to 1.33) in the West (P for interaction=0.038). Dose response meta-analysis suggested for each serving of white rice per day the risk of type-2 diabetes was at 1.11 (1.08 to 1.14) (P for linear trend<0.001). It had been concluded that the higher intakes of white rice was accompanied with a higher risk of type-2 diabetes. [3]

Acetic Acid

There were 10 participants, all with type-1 diabetes and diabetic gastroparesis, included in the double blind trial. GER (gastric emptying rate) was measured with real time ultrasonography. The gastric emptying rate was then calculated as percentage differences in the antral cross-sectional area 15 and 90 minutes following consumption of 200ml of water and 300g rice pudding, or 200ml of water along with 30ml apple cider vinegar. The participants had ingested 200ml of water per day (GER1) prior to breakfast. The same participants had then ingested 200ml of water with 30ml of vinegar per day (GER2) prior to breakfast for a length of two week prior to measurements. In conclusion, the median values of GER 1 and 2 were both at 27% and 17% respectively. The activities of vinegar on GER were extremely significant (p < 0.05). [4]

Prevagen Side Effects:

While natural weight-loss supplements may seem like the safer option, they still come with risk. With every formula, there is the potential for a negative reaction. Though Prevagen side effects are rather uncommon, that doesn’t mean they don’t exist for some users.

Fainting

Syncope or fainting is a sudden loss of consciousness for a brief amount of time. It may come from a sick feeling and often nausea is associated with fainting. Some injuries may be caused by fainting, since the person usually falls to the ground suddenly.

What causes fainting?

Fainting may be caused by a number of different conditions. It may be caused by heart issues, low blood sugar, anemia, seizures, irregular heartbeats, nervous system issues, genetic issues and certain medications. [1] Usually, fainting only lasts a few minutes.

Chest Pains

Any pain felt in the chest may be described as a chest pain. Not all chest pains are heart related. A momentary chest discomfort may be felt or the discomfort may only be associated with breathing. Some types of chest pain actually get better with exercise, as well.

What causes chest pains?

While a heart attack is the most common cause of chest pains, it’s not the only cause. Chest pain may also be caused by angina, aortic dissection, pericarditis, heartburn, gallbladder issues, sore muscles, injured ribs, a panic attack, shingles, pulmonary embolism, collapsed lung or pleurisy. [2] Even some medications and supplements may cause chest pain.

Tremors

An involuntary quivering movement is known as tremors. This movement may be rhythmic and may feel like a to-and-fro type of movement. Often, tremors affect the arms, hands, face, voice, legs and head. Most commonly, tremors occur in the hands.

What causes tremors?

Tremors may be caused by many different health issues including Parkinson’s disease, liver failure or alcoholism. You may also experience tremors if you suffer from arsenic poisoning or mercury poisoning. Tremors are a common side effect of antidepressants, other medications and some supplements.

Heart Arrhythmia

Any problem with your heart rhythm is known as heart arrhythmia. This happens when the electrical impulses coordinating your heartbeats are not working correctly. It may feel like a racing heart beat or like your heart is fluttering.

What causes heart arrhythmia?

While some of the causes of heart arrhythmia are harmless, some are very serious. An electrolyte imbalance in the blood may cause an arrhythmia, while a more serious cause is coronary artery disease. Changes in blood pressure may also cause heart arrhythmia, along with some medications and supplements.

Prevagen side effects are rare, but reports of fainting, chest pains, tremors, heart arrhythmia and other reactions have surfaced from some users. To ensure your protection, always speak with a doctor before starting a new supplement, especially if you’re already taking medication, suffer from a medical condition, you’re pregnant, nursing or you’re under the age of 18.

One that’s caught our eye is Leptigen. There’s no talk of harmful side effects and it’s backed by positive customer reviews.

Prevagen is a supplement formulated to improve or support memory. There is science behind the ingredient they've chosen and while there is no connection to weight-loss, if this is an issue you're dealing with it may be a good option.

Prevagen Ingredients and Supplement Facts

Serving Size: 1 Capsule
Serving Per Container: 30
Amount per Serving % DV
Prevagen Regular Strength * *
- Apoaequorin 10mg *
Prevagen Extra Strength * *
- Apoaequorin 20mg *

Other Ingredients: Microcrystalline cellulose, vegetable capsule, salt, vegetable sourced magnesium stearate

We examined the Prevagen ingredients in order to give you the facts you want.

Apoaequorin

Apoaequorin is a protein derived from glowing jellyfish [1]. It has become a popular ingredient in some dietary supplements for weight-loss.

What Is It Supposed To Do?

Apoaequorin is consumed to treat memory, mental function, and sleep quality.

Clinical Research

When the safety of apoaequorin [2] was tested, researchers concluded, “Based on the results of this study, the No Observed-Adverse-Effect Level (NOAEL) for Apoaequorin was determined as 666.7 mg/kg bw/day, the highest dose tested.” This study was published in Food And Chemical Toxicology : An International Journal Published For The British Industrial Biological Research Association. Nothing was noted for its ability to induce weight-loss.

White Rice Flour

White rice flour is made from milled rice. It is sometimes used as a replacement for wheat flour for those who are gluten intolerant.

What Is It Supposed To Do?

White rice flour contains dietary fiber and protein, which can be beneficial to general organ health. It also contains vitamins and nutrients like calcium and zinc.

Clinical Research

According to Arya Atherosclerosis, “Although there was no significant association between white rice intake and obesity factors in our study, more studies are necessary with larger population and better design.” Nothing was stated about white rice flour.

Acetic Acid

Acetic acid is the main chemical found in vinegar. It is typically manufactured in the United States, Europe, and Japan. It is sometimes used in physical therapy.

What Is It Supposed To Do?

Acetic acid is sometimes used to treat ear infections, head lice, nail fungus, and impetigo.

Clinical Research

According to a study published in Bioscience, Biotechnology, and Biochemistry, “In conclusion, daily intake of vinegar [the source of acetic acid] might be useful in the prevention of metabolic syndrome by reducing obesity.” No studies were available concerning its individual connection to weight-loss.

One that’s on our radar is one called Leptigen. It contains clinically-tested ingredients shown to help boost metabolism and ignite fat loss.

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About the Author:

Summer Banks, a content strategist at Leptigen, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 3.9. From 303 votes.
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User Comments

108 Comments on "Prevagen Review"

 
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All I can say is dam headaches from this product
Don’t buy it

my wife has been taking Prevagen for about two months and now has had a red rash on her face and swelling on both eyes,with a burning and itching sensation

Hi. Please make sure she consults with her physician before continuing to take this product and let them know about the side effects she was experiencing.

AT SEVENTY EIGHT I DECIDED TO INCREASE TAKING EXTRA STRENGTH PREVAGEN AND IT HAS BEEN A COMPLETE DISASTER. MY BLOOD PRESSURE HAS GONE UP AND UP , BECOMING VERY DIZZY AND NOT BALANCED. SEEING A DOCTOR SOON. MY HEALTH WAS EXCELLENT UNTIL TAKING PREVAGEN WITH THE SIDE EFFECTS.

I’m getting mixed messages, is Prevagen for memory or diet?

Hi! For detailed product and usage information, please refer to the Prevagen official website for more details.

Why have you not mentioned that they test these products on dogs. How could that be ethical. When has an animal ever been able to advise what it is feeling, unless they give the animal the product and then kill it to test parts of their organs. The makers of the product should be ashamed.

I have been taking prevagen for over a year. I heard it recommended highly by a doctor who has a radio show. I did not hear anything about weight loss–and that was not my goal. Memory loss is my problem. I had no side effects. I honestly can’t say if it worked or not, because memory loss can increase with time–so I have kept taking it in case my memory would be worse without it. The last two months I took the double dose. Still no side effects or noticeable results. So I have decided to stop prevagen and see what happens. If my memory become suddenly worse, I will start again! But the price really is prohibitive. And there are other ways to help the brain . . . exercise the brain and the body, and eat a healthy diet (no sugar–lots of fish and greens) Get plenty of oxygen. I am 82 years old now, and my memory is failing, and that is normal, I guess. But if I want to live a rich and active life into old age, I will keep working at it.

I tried it for two weeks and noticed improved speed of memory, however it was more like taking extra caffeine.. I stopped taking for two weeks as I was experiencing dizzy spells.and didn’t notice any changes with memory. Today I tried again and had dizzy spell so I will not be taking again.

Your explanation obviously flawed. Prevagen is supposed to be for memory not weight loss.

I think prevagen worked really well. I had immediate sharpness. However after 4 months of use I noticed an issue with erectile disfunction. I got off of it and everything went back to normal.

I took it for awhile and noticed a difference right away. However, I developed a rash all over my stomach and thighs. After some research I found that the ingredient from jellyfish causes rashes in some people. I stopped the prevagen and the rash disappeared within a few weeks. It got a little better everyday starting from the first full day without the prevagen.

57 year old female, good health, heart disease in family background – both sides. Been taking extra strength Prevagen for about 18 weeks. Memory, flow of sentences, focus, (without doubt) noticeably better. Sometimes I even remember what I’d dreamt overnight…in detail ! (Something I’ve not been able to do at all for at least the last 5 years!) Blood pressure, which has always hovered around 60-70 over 110, raised to 90 over 120 this last month.. Left foot has been swollen (edema) last 6 weeks, and (embarrassed to say) incontinence – a slight issue now and then, had become far from ‘slight’.

I went off of Prevagen 6 days ago. Swelling down, blood pressure back to normal, and yes….incontinence issues waning. Go figure?! Damned if I take it, damned if I don’t. Will try cutting back to normal strength, or cutting back on dosages over next few months to see if I can reach a good midpoint between heart & bladder negatives vs. big mind positives.

This is thw worst product i have ever consumed. I took prevagen for a month and ended up havind symptoms of multiple sclerosis with fatigued leg and . My memory declined and faced visual problems. My advice is to stop production of this product to prevent further damage to people .

I had a head injury that left me with memory issues and heard about prevagen helping with this type of thing so I looked up all the info I could find on it and it sounded legit so I bought some and started taking it. The first dose I got a severe headache and stomach cramps but I wasn’t sure if it was all due to prevagen so I waited two days and tried again. More headaches and stomach cramps. I read where there side effects might subside with continued use and I really needed help with memory so I tried it for a whole week straight. The bad side effects never got better. I will have to keep looking for something else. If I can remember.

My wife suffers from dementia.When I heard about Prevagen, I began giving it to her for memory loss. About 4 months later, she fell in the bathroom and broke her pelvis. Still, I didn’t associate her fall to the drug. But in the last week, I have noticed that she is irritable and somewhat more confused about where she is. I tried taking the Prevagen myself to see what near-term effect it may have. I suffer from 75% disability with combat-related PTSD. Last night, I began reliving bad war experiences and awakened in a cold sweat. I feel anxious and paranoid. Perhaps Prevagen is contributing to her confusion and anxiety as well. Sitting here typing this, I feel dizzy and somewhat confused. One thing for sure, I’m not giving her further doses of Prevagen and I am not taking it myself.

It gave me stomach cramps and diarrhea and nausea after 2 hours.

I took one extra strength Prevagen and about 2 hours later I got stomach cramps and nausea. I had diarrhea and almost vomited at the same time. I’m very careful of what I eat. This condition was definitely caused by the Prevagen. Never again.

It gave me a really bad headache, i was feeling my heart beats literally in my head. And I dont normally get headaches

Where I can buy it in the Philippines?

Hi Charlie! For more information on where to purchase this product, please refer to the Prevagen official website.

Your NameJohnny Evagelista

Tell us your thoughts about Prevagen.I’ve learning disability. my IQ is 67 can this drug help me in some way!

Hi! Please make sure to consult with your physician before starting a new weight-loss program or product.

Johnny EvangelistaYour Name

No I havn’t taking Prevagen yet. I have learning disability. since from the first grade. can it help me in a way.

Hello. All users are different and can experience different results, but please make sure to consult with your physician before taking this product.

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