Updated: 01/10/2018

Memory supplements and brain supplements hit the market like wildfire. But, do they work? That’s the question everyone wants answered. So, you may be surprised by what I say in this Prevagen review. We keep hearing about the active ingredient in Prevagen called apoaequorin. However, we’ll also take a closer look at the Prevagen side effects and research backing the formula. After reading hundreds of user comments and testimonials, we summarized the facts for you.

Prevagen Readers: Click here to find out why we're giving away samples of our product, Burn HD.

What is Prevagen?

First off, Prevagen is an herbal remedy product for brain and memory health which prevent memory loss and improve concentration. This brain supplement is produced by the Quincy Bioscience company.

According to its manufacturer, Prevagen consisted of a protein from jellyfish called apoaequorin, which promotes and enhances brain function.

This protein supposedly reduces excess calcium levels in the brain and improve short-term memory problems. It also contains vitamin D.

Products Similar to Prevagen

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How Did Prevagen Start?

Prevagen contains apoaequorin, a protein that was originally discovered in the Aequorea Victoria jellyfish.

According to WebMed, “Problems with calcium regulation in the human brain are thought to play a role in age-related mental decline. Because apoaequorin has a similar structure to human calcium-binding proteins, some researchers believe it might help regulate calcium in the brain and reduce memory loss and mental decline” [1]

Prevagen Customer Testimonials

Prevagen Claims

Prevagen claims to improve the health and function of the brain. According to PubMed, “Pharmacological manipulation of the entry of free calcium (Ca2+) has been shown to be effective in increasing some aspects of cognitive function in the aged brain. Apoaequorin has been shown in laboratory studies to regulate levels of intracellular calcium in neuronal cells and to provide protection against ischemic cell death.” [2]

Research shows that consuming 10 Mg of Prevagen per day for 90 days will improve mental quality of older adults. Other research suggests that consuming 20 mg Prevagen 2 or 3 hours after wake up and 30-60 mg, 30 min before bed along with other drugs will reduce the progression of ALS.

Prevagen Ingredients

Prevagen contains the following ingredients:

  • Apoaequorin
  • White Rice Flour
  • Sodium Chloride
  • Magnesium Stearate
  • Acetic Acid

A serving size of Prevagen is equal to 1 capsule, and 30 servings come in a container of the supplement. There is 20 mg of apoaequorin in every serving.

Does Prevagen Work?

Apoaequorin is an important protein in Prevagen meant to improve the function of the brain. Some research suggests this ingredient helps in cases with mild health problems, with still little to no effect on them.

Its company claimed that it enters the brain to supplement proteins lost during the aging process. However,

“According to the FTC and New York AG, the defendants don’t have studies showing that apoaequorin taken orally ever reaches the brain: ‘To the contrary, Defendants’ safety studies show that apoaequorin is rapidly digested in the stomach and broken down into amino acids and small peptides like any other dietary protein.'”[3]

Prevagen Benefits and Results

Prevagen may be a good product for mild health problems, particularly ones due to aging. It may be suitable for adults want to improve short-term memory overall brain health.

It also contains no stimulants, unlike other brain supplements.

Prevagen contains no allergens and is easy to take. It includes a money back guarantee in 30 days.

Berkley wellness claimed that:

“The primary ingredient in Prevagen is a synthetic version of apoaequorin, a protein originally derived from certain jellyfish. The Prevagen researchers hypothesize that, by regulating levels of intracellular calcium, “apoaequorin has the potential to improve the function of aging neurons and, therefore, to enhance memory and cognitive function.” This is scientifically implausible.

Even if this hypothesis were true, as the FTC points out, the company’s own “safety studies show that apoaequorin is rapidly digested in the stomach and broken down into amino acids and small peptides like any other dietary protein.” And even if the orally consumed protein somehow got into the bloodstream, there’s no evidence that it can cross the human blood-brain barrier to affect neurons.”[4]

How to Use (Take) Prevagen

For improvement in memory, commonly resulted by aging, 90 days regular use of this supplement is recommended. According to WebMed,

“The appropriate dose of apoaequorin depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for apoaequorin (in children/in adults).

Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.” [5]

If you want to use Prevagen with other medications, we aren’t aware of any negative interactions; but it’s better to talk with your doctor before beginning Prevagen use.

Potential Prevagen Side Effects

The side effects reported by Some people in the first few weeks of using Prevagen, including headaches, itching, dizziness, diarrhea, and increased blood pressure. According to PubMed,

“Apoaequorin is POSSIBLY SAFE when taken by mouth appropriately. A 10 mg dose of a specific apoaequorin product (Prevagen, Quincy Bioscience) has been used safely for up to 90 days. No clinical research has adequately evaluated side effects caused by apoaequorin. Some people who have taken apoaequorin have reported potential side effects to a manufacturer of the product. Some of the most commonly reported side effects were headache, dizziness, and nausea.

Others less common events were memory problems, difficulty sleeping, and anxiety. There have also been a smaller number of reports of more serious potential side effects such as heart and nervous system-related events. It is important to understand that although these events occurred while people took this product, this does not necessarily mean that the product caused these events. There is not enough information about these potential side effects to know if apoaequorin was the actual cause of these side effects” [1]

Warnings about Prevagen

The FDA has run into trouble with Prevagen before. They accused the supplement company of not reporting some serious side effects, like fainting, chest pain, and even seizures.

Apparently, Prevagen received more than 1,000 reports concerning these effects between 2008 and 2011, but only reported 2.

It’s easy to say that Prevagen isn’t FDA approved.

Unfortunately, the website concealed side effects that may occur as a result of the treatment. The supporting studies described on the website were very limited, and are not independently verified. The evidence supporting the supplement is not quantitative either.

Prevagen Alternatives

There are a lot of brain products, and Lumonol Wisdom is one of them. Lumonol Wisdom is a new product created by Avanse Nutraceuticals.

This product contains Noonpet, a compound claiming to provide a variety of benefits including:

  • Improved Memory Recall
  • Increased Memory Capacity
  • Improved Learning Skills
  • Increased Processing Speed
  • Enhanced Mood

Noopept in Lumonol acts in three different ways to affect the brain. First, it affects two brain receptors, NMDA and AMPA, which are effective factors in the human learning process.

Second, it is supposed to influence the nerve growth factor and brain neurotrophic factor, both of which are essential elements in the health and vitality of neurons.

Third, it apparently increases acetylcholine in the brain, the neurotransmitters that help humans learning and retain memories. This might make it a good alternative for Prevagen.

Prevagen Alternatives

Prevagen isn’t cheap, but if you order direct from the company, a month’s supply of pills will cost you $66 with shipping. It’s also available on Amazon, eBay, Walgreen websites.

However, before buying, there are some alternatives you should consider.

Prevagen Extra Strength

Prevagen Extra Strength is just a stronger version of the original formula. It claims to be an advanced “brain enhancement supplement,” saying it can:

  • Increase Mental Function
  • Promote Clearer Thinking
  • Improve Overall Brain Health

One bottle, or a month’s supply, can be purchased both from the official website and third-party retailers. Money back guarantees will depend on the policies of those you purchased it from.

Prevagen Extra Strength claims that, with continuous use, the user will experience a sharp mind, improved memory, and increased concentration. The supplement also contains no common allergens or artificial stimulants.

Just like the original formula, Prevagen Extra Strength’s main ingredient is apoaequorin.

Prevagen vs. Focus Factor

Indeed, Focus Factor is like a typical multivitamin, and it has long and complicated list of ingredients, but this product improves mind and memory.

The ingredient list in Focus Factor mainly consists of a wide variety of vitamins, micronutrients, and minerals, as well as some fruit extracts and natural herbs. One of the main concerns with this brain supplement, though, is its lengthy ingredient list.

Although there have been no reports of any significant side effects of the supplement, in some cases, the use of Focus Factor can lead to gastric upset.

Prevagen vs. Alpha Brain

Alpha Brain is another brain supplement rivaling Prevagen. This product focuses on boosting concentration, memory, and energy, making it popular with executives and college students. Ingredients in this one include:

  • Alpha GPC
  • Huperzine A
  • Vinpocetine
  • AC-11
  • Bacopa
  • L-Tyrosine
  • L-Theanine

The company behind Alpha Brain claim its ingredients are responsible for its claimed benefits. It costs about $26 on Amazon.

What Users Are Saying

“I am a senior citizen and have been using this product for months with great results.”

“Appears to help some with recent memory, hard to quantitate.”

“I took this for several months…probably four. or five. I have chemo brain and thought it would improve my short term memory loss. I really didn’t notice any improvement.”

The Bottom Line – Does Prevagen Work?

So, should you race out to buy Prevagen? Well, we like that Prevagen is easy to find and that we found, but the research not pointing toward weight-loss leaves us concerned. Furthermore, we have some issues with the numerous customer complaints, especially relating to adverse effects.

Do you want to lose weight and improve wellness? Consider combining Prevagen with a supplement containing clinically-tested ingredients shown to help with weight-loss.

Among the best products we’ve seen this year is one called Burn HD. This supplement contains clinically-tested ingredients, which have been shown to help boost metabolism and accelerate fat loss. We have not found any talk of harmful side effects and user comments indicate people are seeing substantial results.

The makers of Burn HD are so confident in their product they’re offering a 2-Week Sample, which is a good sign.


Learn More About Burn HD »
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What is Prevagen and how does it work?

Prevagen is a protein supplement collected from jellyfish that is intended to promote healthy brain functions, better memory, and clearer thinking.

What are the side effects of Prevagen?

The manufacturer received reports of headaches, dizziness, nausea, minor memory problems, anxiety, and sleeplessness from people after taking apoaequorin.

How do I know if Prevagen is right for me?

Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients.

Click here to get your sample of our powerful fat burner today.

What are the ingredients of Prevagen?

The key ingredient in Prevagen is a protein obtained from Puget Sound jellyfish. The patented brand is Apoaequorin. Other ingredients include magnesium stearate and the organic compound acetic acid.

What is the main ingredient in Prevagen?

Apoaequorin, pronounced ah-poe-ah-cor-in, is a synthetic protein supplement derived from jellyfish, and it is the main ingredient in Prevagen, which is used to promote memory enhancement and cognitive functions.

How does Prevagen work in the brain?

The manufacturer claims research shows Prevagen delivers a cell supporting protein that is normally diminished with aging and expose brain cells to damage.

How much does a bottle of Prevagen cost?

A bottle of Prevagen costs $59.95. If you buy two bottles, the price increases to $119.90. Three runs $239.80 and eight is $479.60. You receive a discount on multiple bottle purchases.

How do you take Prevagen?

You take one Prevagen capsule in the morning with or without food. One bottle lasts 30 days.

What is Prevagen used for?

Clinical studies show Prevagen helps with age related mild memory problems.

Who makes Prevagen?

Manufacturers Quincy Bioscience, a Madison, Wisconsin biotechnology company focusing on innovative approached to help cognitive functioning and age related challenges with mild memory problems.

What is the main ingredient in Prevagen?

The main ingredient in Prevagen is apoaequorin. This is found in certain species of jellyfish.

Can I purchase Prevagen at local stores?

Yes, you can purchase Prevagen at local retailers. You may not receive the multiple bottle discounts.

Has the Food and Drug Administration contacted the makers of Prevagen?

Yes, the FDA sent letters to Quincy Bioscience Manufacturing relating to mislabeling of the supplement and claims made by the company.

Is there a guarantee with Prevagen?

Yes, there’s a guarantee with Prevagen. You can return any portion of the supplement for a complete refund of your money within 30 days.

Prevagen Ingredients

Prevagen is a supplement formulated to improve or support memory. There is science behind the ingredient they've chosen and while there is no connection to weight-loss, if this is an issue you're dealing with it may be a good option.

Prevagen Ingredients and Supplement Facts

Serving Size: 1 Capsule
Serving Per Container: 30
Amount per Serving% DV
Prevagen Regular Strength**
- Apoaequorin10mg*
Prevagen Extra Strength**
- Apoaequorin20mg*

Other Ingredients: Microcrystalline cellulose, vegetable capsule, salt, vegetable sourced magnesium stearate

We examined the Prevagen ingredients in order to give you the facts you want.


Apoaequorin is a protein derived from glowing jellyfish [1]. It has become a popular ingredient in some dietary supplements for weight-loss.

What Is It Supposed To Do?

Apoaequorin is consumed to treat memory, mental function, and sleep quality.

Clinical Research

When the safety of apoaequorin [2] was tested, researchers concluded, “Based on the results of this study, the No Observed-Adverse-Effect Level (NOAEL) for Apoaequorin was determined as 666.7 mg/kg bw/day, the highest dose tested.” This study was published in Food And Chemical Toxicology : An International Journal Published For The British Industrial Biological Research Association. Nothing was noted for its ability to induce weight-loss.

White Rice Flour

White rice flour is made from milled rice. It is sometimes used as a replacement for wheat flour for those who are gluten intolerant.

What Is It Supposed To Do?

White rice flour contains dietary fiber and protein, which can be beneficial to general organ health. It also contains vitamins and nutrients like calcium and zinc.

Clinical Research

According to Arya Atherosclerosis, “Although there was no significant association between white rice intake and obesity factors in our study, more studies are necessary with larger population and better design.” Nothing was stated about white rice flour.

Acetic Acid

Acetic acid is the main chemical found in vinegar. It is typically manufactured in the United States, Europe, and Japan. It is sometimes used in physical therapy.

What Is It Supposed To Do?

Acetic acid is sometimes used to treat ear infections, head lice, nail fungus, and impetigo.

Clinical Research

According to a study published in Bioscience, Biotechnology, and Biochemistry, “In conclusion, daily intake of vinegar [the source of acetic acid] might be useful in the prevention of metabolic syndrome by reducing obesity.” No studies were available concerning its individual connection to weight-loss.

One that’s on our radar is one called Dietspotlight Burn. It contains clinically-tested ingredients shown to help boost metabolism and ignite fat loss.

Prevagen Scientific Abstracts


Neurons from OGD were dose-dependently shielded by apoaequorin. At doses of 1% and 4%, there was a significant reduction in number of trypan blue-labeled neurons. This time dependent effect lasted 48 hours. This effect had been mirrored by alterations in chemokine and cytokine expression, suggesting that apoaequorin could shield neurons through a neuroimmunomodulatory mechanism. This data reveals that pretreatments with apoaequorin will indeed protect neurons from ischemic cell death, and could be an effective neurotherapeutic. [1]

The study was put into place to discover if there had been adverse effects to apoaequorin in rats, after subchronic administration. The results had shown NOAEL (No Observed-Adverse-Effect Level) for apoaequorin was at 666.7 mg/kg bw/day tested at the highest dose. There had not been any mortality resulting from administration of apoaequorin. There had been no signs of body weight gain, food efficiency, food consumption, histopathological, or clinical pathology differences which could point toward apoaequorin administration. [2]

White Rice

Data was compiled from perspective and cohort studies showing the Asian populations having much higher rice ingestion levels than the West (average intake was three to four servings per day vs. one to two servings per week). Pooled relative risk was at 1.55 (95% CI 1.20 to 2.01) when weighing the highest and the lowest white rice consumption in Asian populations, and the comparable relative risk was at 1.12 (0.94 to 1.33) in the West (P for interaction=0.038). Dose response meta-analysis suggested for each serving of white rice per day the risk of type-2 diabetes was at 1.11 (1.08 to 1.14) (P for linear trend<0.001). It had been concluded that the higher intakes of white rice was accompanied with a higher risk of type-2 diabetes. [3]

Acetic Acid

There were 10 participants, all with type-1 diabetes and diabetic gastroparesis, included in the double blind trial. GER (gastric emptying rate) was measured with real time ultrasonography. The gastric emptying rate was then calculated as percentage differences in the antral cross-sectional area 15 and 90 minutes following consumption of 200ml of water and 300g rice pudding, or 200ml of water along with 30ml apple cider vinegar. The participants had ingested 200ml of water per day (GER1) prior to breakfast. The same participants had then ingested 200ml of water with 30ml of vinegar per day (GER2) prior to breakfast for a length of two week prior to measurements. In conclusion, the median values of GER 1 and 2 were both at 27% and 17% respectively. The activities of vinegar on GER were extremely significant (p < 0.05). [4]


Previous Prevagen Review (Updated June 16, 2014):

What You Should Know about Prevagen

The brain protects its cells from degradation by generating a protein that regulates cellular calcium. If calcium increases in cells, they will be destroyed. With the natural aging process, the body generates that protein in lesser amounts. Prevagen is a supplement that promotes the better health of the brain and its functions, in much the same way Focus Factor does. The product focuses on improving memory loss and protecting the brain by supplying it with a protein called apoaequorin. This protein belongs to a family of molecules that binds calcium. Prevagen can easily be bought from health food stores as well Rite Aid stores. However, the website’s online shopping page allows interested clientele to purchase the amount they want.

List of Prevagen Ingredients

The only ingredient that is mentioned on the website is the apoaequorin protein, which is extracted from jellyfish. Even the concentration of that protein isn’t mentioned in the Prevagen material.

Product Features

Prevagen claims to bind calcium in cells, thus reducing the damage which occurs when the body doesn’t produce many calcium binding proteins as it ages. Prevagen, like Vibra Slim, is designed for people 40 and older. The apoaequorin protein, which was discovered in the early sixties, is apparently responsible for the whole calcium binding process. Prevagen, along with Ambislim PM, also promotes restful sleep. This effect is a double-sided coin, as we discuss on our Prevagen Side Effects review The research conducted by the supplement’s developers supposedly demonstrated that the apoaequorin protein mainly benefits consumers by enhancing their mental clarity, honing their decision-making skills, improving their memory and helping them focus. This affect on the brain is similar to how the leptin in Leptinal impedes the hunger signals in your brain. However, these claims haven’t been confirmed by the FDA. Still, the website promises consumers positive results between periods of use from 30 and 90 days. Aside from that, the product has been approved to be kosher by two of the four main production facilities in the United States.

Advantages of Prevagen

  • The website does offer supporting evidence regarding Prevagen’s effects on memory and sleep.
  • An informative video explains how the supplements will enhance the brain’s functionalities.
  • The website directly states that it hasn’t been FDA approved, thus spares consumers the time and effort of trying to locate the FDA approval stamp.

Disadvantages of Prevagen

  • The product isn’t FDA approved. Although the website was truthful enough to mention this fact, it still isn’t a favorable factor.
  • There are no indications regarding Prevagen being free from side effects.
  • The supporting studies were limited studies, not full-scale ones.
  • The evidence supporting the product is mainly anecdotal and not quantitative.


Age does affect the body in various ways, and the brain is no exception. Age has a very taxing affect on the body and mind; numerous products including Nature's Pearl try to tackle this. If Prevagen is really as good as it claims to be, people will really benefit immensely. However, with the supplement’s shortcomings, caution should be taken prior to its consumption.
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.

110 Prevagen Reviews

  • Kay

    I’m getting mixed messages, is Prevagen for memory or diet?

  • Johnny EvangelistaYour Name

    No I havn’t taking Prevagen yet. I have learning disability. since from the first grade. can it help me in a way.

    • Adrian (Editor)

      Hello. All users are different and can experience different results, but please make sure to consult with your physician before taking this product.

  • Sherry young

    Just started 3 days ago. Hoping it works.

    • Maribel (Editor)

      Hope it works too! If not, try out Dietspotlight Burn. This product is great for so many things: energy, weight-loss and fat-burn.

  • Charlie

    Where I can buy it in the Philippines?

  • i forgot my name...

    i bought it..i take exams and fail due to the fact that I as I get older (I’m 37 now) I cant even remember where the grocery store is anymore let alone names from books for exams. I have been diagnosed by a neurological doctor to have pseudo dementia cusing impaired memory and speech issues remembering the right word to use ( I say “thing or thingy” ALOT instead or just plainly a different word and substitute the missing word for a different word like look at the bike “tire” and instead I say look at the …(pause)… “door”) I have taken one pill. I felt dizzy when riding my bike uphill and almost passed out..this could be due to the fact that I have an upper respiratory infection at this time however, but my jumbled words I have due to memory loss issues and memory itself has not improved by just one pill starting I took yesterday 3/23/2017 yet..will try to keep this place informed of my personal studies.

  • Scott A

    One hundred, fifty-five peered reviewed scientific papers dating back to 1981 have been published about Apoaequorin, the claimed active ingredient in Prevagen. Most of the scientific publications describe studies involving the biochemical analysis and in vitro experimental use of apoaequorin as a basic research tool. Two publications, conducted by Quincy Bioscience, examine the safety profile of Prevagen in Sprague-Dawley rats following oral dosing. The same scientific group also treated 218 adults aged 40-91 years old for 90 days and reported apoaequorin was well-tolerated. (https://www.ncbi.nlm.nih.gov/pubmed/26878676). The results provided in all three studies do not demonstrate that any apoaequorin is absorbed by the intestine and nor is it detected in the bloodstream. The lack of circulating apoaequorin comes as no surprise as nearly all ingested proteins are degraded into their 20 amino acid constituents prior to absorption. Allergic reactions to orally ingested proteins and their formulations is quite common as one probably knows someone with food allergies. Dietary supplements like Prevagen should not be confused with ethically developed and FDA approved medications. One can spend their money on products such as this but the reality is that there has been no demonstration of effective treatment for anything.

  • John

    my wife has been taking Prevagen for about two months and now has had a red rash on her face and swelling on both eyes,with a burning and itching sensation

    • Anna (Editor)

      Hi John. So sorry to hear this, please have her visit her doctor and see which ingredients are causing her this reaction. Maybe another product could work better for her? Dietspotlight Burn could be a good alternative, not many users have reported side-effects. Hope this helps.



    • Jonathan Singer

      If your health was excellent…why did you start taking Prevagen?

  • It works
    Tammy Watson (Verified User)

    I have had short term memory loss fro a tumor 4 brai surgeries and a stroke last yr I noticed less problems w this after a month

  • Stopping abruptly??
    Tammy (Verified User)

    Is it safe to abruptly stop Prevagen if you have been taking it for a long time?

    • Yedy Torres

      Hi Tammy,

      We recommend to consult your physician to make sure this product wont have any adverse side effects from stopping the supplement.

  • Jane Patrick

    I have been taking prevagen for over a year. I heard it recommended highly by a doctor who has a radio show. I did not hear anything about weight loss–and that was not my goal. Memory loss is my problem. I had no side effects. I honestly can’t say if it worked or not, because memory loss can increase with time–so I have kept taking it in case my memory would be worse without it. The last two months I took the double dose. Still no side effects or noticeable results. So I have decided to stop prevagen and see what happens. If my memory become suddenly worse, I will start again! But the price really is prohibitive. And there are other ways to help the brain . . . exercise the brain and the body, and eat a healthy diet (no sugar–lots of fish and greens) Get plenty of oxygen. I am 82 years old now, and my memory is failing, and that is normal, I guess. But if I want to live a rich and active life into old age, I will keep working at it.

  • Jimb

    I tried it for two weeks and noticed improved speed of memory, however it was more like taking extra caffeine.. I stopped taking for two weeks as I was experiencing dizzy spells.and didn’t notice any changes with memory. Today I tried again and had dizzy spell so I will not be taking again.

  • Do your research
    Homer A Taylor

    While some products work for some, but not all, people must come to realize that we are not all the same with the same chemical components in our bodies. In the final conclusions of all cures and helpful remedies, we will find that not all products work for all people.

  • Yes

    Your explanation obviously flawed. Prevagen is supposed to be for memory not weight loss.

  • Ted Richardson

    I think prevagen worked really well. I had immediate sharpness. However after 4 months of use I noticed an issue with erectile disfunction. I got off of it and everything went back to normal.

  • Connie

    I took it for awhile and noticed a difference right away. However, I developed a rash all over my stomach and thighs. After some research I found that the ingredient from jellyfish causes rashes in some people. I stopped the prevagen and the rash disappeared within a few weeks. It got a little better everyday starting from the first full day without the prevagen.

  • Victoria

    57 year old female, good health, heart disease in family background – both sides. Been taking extra strength Prevagen for about 18 weeks. Memory, flow of sentences, focus, (without doubt) noticeably better. Sometimes I even remember what I’d dreamt overnight…in detail ! (Something I’ve not been able to do at all for at least the last 5 years!) Blood pressure, which has always hovered around 60-70 over 110, raised to 90 over 120 this last month.. Left foot has been swollen (edema) last 6 weeks, and (embarrassed to say) incontinence – a slight issue now and then, had become far from ‘slight’.

    I went off of Prevagen 6 days ago. Swelling down, blood pressure back to normal, and yes….incontinence issues waning. Go figure?! Damned if I take it, damned if I don’t. Will try cutting back to normal strength, or cutting back on dosages over next few months to see if I can reach a good midpoint between heart & bladder negatives vs. big mind positives.

  • Debanjan Das

    This is thw worst product i have ever consumed. I took prevagen for a month and ended up havind symptoms of multiple sclerosis with fatigued leg and . My memory declined and faced visual problems. My advice is to stop production of this product to prevent further damage to people .

  • Katy Williams

    I had a head injury that left me with memory issues and heard about prevagen helping with this type of thing so I looked up all the info I could find on it and it sounded legit so I bought some and started taking it. The first dose I got a severe headache and stomach cramps but I wasn’t sure if it was all due to prevagen so I waited two days and tried again. More headaches and stomach cramps. I read where there side effects might subside with continued use and I really needed help with memory so I tried it for a whole week straight. The bad side effects never got better. I will have to keep looking for something else. If I can remember.

  • Anthony

    My wife suffers from dementia.When I heard about Prevagen, I began giving it to her for memory loss. About 4 months later, she fell in the bathroom and broke her pelvis. Still, I didn’t associate her fall to the drug. But in the last week, I have noticed that she is irritable and somewhat more confused about where she is. I tried taking the Prevagen myself to see what near-term effect it may have. I suffer from 75% disability with combat-related PTSD. Last night, I began reliving bad war experiences and awakened in a cold sweat. I feel anxious and paranoid. Perhaps Prevagen is contributing to her confusion and anxiety as well. Sitting here typing this, I feel dizzy and somewhat confused. One thing for sure, I’m not giving her further doses of Prevagen and I am not taking it myself.

  • Chris

    It gave me stomach cramps and diarrhea and nausea after 2 hours.

  • Chris

    I took one extra strength Prevagen and about 2 hours later I got stomach cramps and nausea. I had diarrhea and almost vomited at the same time. I’m very careful of what I eat. This condition was definitely caused by the Prevagen. Never again.

  • Luis

    It gave me a really bad headache, i was feeling my heart beats literally in my head. And I dont normally get headaches

  • Your NameJohnny Evagelista

    Tell us your thoughts about Prevagen.I’ve learning disability. my IQ is 67 can this drug help me in some way!

    • Jessica (Editor)

      Hi! Please make sure to consult with your physician before starting a new weight-loss program or product.

  • RMcAninch

    My vertigo increased almost immediately and my brain felt like I was swimming under water. Waste of money.

  • Your ortencia

    I,ve been reading the reviews . this is my expierience with “Prevegan” I,ve read alot of positive and negative feedback my expierence was that I also purshade the product hoping to relieve or improve my memory loss. i’ve been taking this prouduct for the past two weeks and decided to stop. The first few days I did see a change on my facial expession. I kept tking it I’ve been expierencing numbness in my legs sluggish and dizziness when walking, still fforgetting the usual daily tasks, I’ve also developed a sense of paranoia, ive never felt this before. . this is what I’ve expierenced within 3 weeks usage. and you know what i not taking this prouduct anymore. Its a shame we’re all trying to feel better and taking a risk with our health our lives . For those of you who have benefitted thumbs up!! As for me Thanks but No thanks. Id like a full refund!!!. Goodluck Everyone

    • Adrian (Editor)

      Hello. All users are different and can experience different results; please make sure to consult with your physician before continuing this product to make sure its safe and effective for you to use.

    • Peter

      Me and my wife have been taking Prevagen off and on when wee can afford it for about 6 years. Not taking more than 2 months brake.We both take 30 mg in the morning.We both onw separate businesses and notice when we not taking it.We search for words in conversation and also challenge each other if we cant remember something whom can think of it first. I really don’t know about all these negative replies. Possibly the people with negative replies are to sick to take it.We both take on average between 30 and 50 pills per day and have been doing it for over 20 years. We’re in late 60’s. We only purchase it if we can buy it on line lot cheaper then in your local health store.Thanks

      • Polly Logan

        I am 70 years young and I too take many vitamin supplements a day. Maybe with you taking a break from Prevagen it dies afford your body to have a break before any negative problems. Just my opinion. Best of continued good health.
        I am a healthy female with HBP on a single water pill. No memory problems. I just thought I’d take it to avert any memory problems in the future.

    • Wendy

      Procera the best

  • Inge

    I have been taking prevagen for four weeks the only thing I got out of it is very bad heardaches

  • Leisa

    I started taking it 3 months ago and now have daily headaches and very high blood pressure. If it did any good, I can’t tell because my headaches are so bad!

  •  Don't waste your money !
    Carroll (Verified User)

    I have used one bottle and since I am able to trace my memory improvement via Lumosity, my memory has not increased but has decreased considerably. It was a bust and a loss of over $50.00.

  • Fisher

    Why don’t you just be straightforward and say that there is ZERO independent scientific research to support the claims that prevagen improves memory. Research conducted by the manufacturer is obviously biased and anecdotal evidence by fisherman Bob and homemaker Gladys is simply ludicrous– whether such reports are positive OR negative. Though I believe you mean well, your analysis is simply inadequate and does not convey any useful information.

  • Mary

    Scary since I had a massive heart attack. 2 years ago. My blood pressure is also slightly elevated so I would be wary of taking this esp. Since it is so expensive. Would be wonderful if it worked since I am having some short term memory problems.

  •  heart arrhythmia
    Henry Rangel (Verified User)

    I am 53,i started prevagen on march 8,I ended on ER on march 12th with heart arrhythmia

  • Prevagen
    Lee scerr

    Made my memory much worse

  •  I am not interested in Previgen
    Your Name (Verified User)

    Andrew: I also have Multiple Sclerosis. I am not interested in Previgen due to side effects. But why do you say MS precludes Previjin?

  • Need information about possible side effects
    Jean Avanzato

    I would like to know the side effects from prevagen. Thank you.

    • Sarah

      Hello, Jean. Some dieters experienced side effects like high blood pressure, fast heartbeat, fainting, chest pains, dizziness, headache and tremors.

  • Questions on how this works

    Prevagen appears to be a protein (apoaequorin). Usually proteins cannot pass thru the intestinal tract and get into the body without first being broken down to the constituent amino acids. How does Prevagen avoid this problem ? If it really enters the body as an intact protein, I would be concerned about allergic reactions ?

    • Sarah

      Hi, Norman. In regards to side effects perhaps leading to allergic reactions and intestinal problems, please ask your physician.

    • Your Name

      basic science…people are dumb!

  •  Very Good Product
    Your Name (Verified User)

    You are so wrong! I am telling you after 35 days my mind is clearer, I am more focused, I can remember things my kids can’t with no effort. This stuff is priceless!!! I feel 25 again and I am 60. Do unless you have tried it yourself you should shut up and let the rest of us help our brains.

    • The Princess

      I’m with you it is wonderful I am more focused than ever but there is one draw back the Jelly Fish, I’m having some issues I get a rash on my arm just my right one. I hate to have to give this up. This is my second month taking Prevalent. I was taking 10mg but I moved it up. I thank I’m going to go back to 10mg and see if I have the same results. Wish me luck!!!

  •  I never experienced any side effects !
    Tim (Verified User)

    Interesting how many comments here are based solely on bashing a product that they never tried. I am a mid 40’s some guy, athletic and eat healthy, and NO I am not being paid or compensated by anyone for my views here. I have been taking this product for quite some time and can say without question that I NEVER experienced any of the so-called “side effects” listed here. Those of you critics that haven’t taken it for an extended period of time, let alone taken it at all, have no say in the matter. In fact, I have noticed that since I STOPPED taking it I have a more difficult time with simple words or names, as well as thinking straight and my ability to focus. Personally I think the side affects from many other prescription drugs are far more harmful. You people really need to settle down and try it for real, and for more than just a few days or even weeks before you have any room to criticize this product.

  • Any Side Effects of This Product
    Tommy Turner (Verified User)

    I have been taking Prevagen for several years…almost since it first came out. I do believe it is helping but I was wondering if it could cause side effect of eye hemorrhages?

    • Jessica

      Hello, Tommy. Some dieters experienced side effects like high blood pressure, fast heartbeat, fainting, chest pains, dizziness, headache and tremors. In regards to eye hemorrhages, please ask your doctor.

  • Garl in the Product
    Your Name

    Does prevegen contain garl I c onions chives or shallots

    • jessica

      Hello, please refer to the prevagen official website to obtain all of the product’s ingredients.

  •  Thanks for a Great Post
    Peggie Zahm

    Thanks for a great post

  •  Leg is swelling
    Margie Seaux (Verified User)

    I have been having swelling in one of my legs, i would like to know if Prevagen can cause this. I have found that my memory is better since taking Prevagen.

    • Sarah

      Hi, Margie. Some Prevagen users experienced side effects like high blood pressure, fast heartbeat, fainting, chest pains, dizziness, headache and tremors. In regards to swelling, please ask your doctor.

  •  trun your stool green
    annie (Verified User)

    does it trun your stool green?

    • Jessica

      Hello, Annie. Some dieters experienced other side effects other than the one you stated. Please refer to the official Prevagen website for all side effects.

  • Previgin over the counter, or perscription
    Ernie Jeffrey

    is Previgin over the counter, or perscription ?

    • Your Name

      Over the counter. Should find it in the vitamin section.

  • Thanks for your input
    Sarah (Verified User)

    Hi Jack. Thanks for your input!

  • Can my husband take this?

    I read some one took prevagen and had a stroke My husband has high blood pressure tell me the truth should he take this??

    • Sarah

      Hello, Joanna. Some dieters experienced side effects like high blood pressure, fast heartbeat, fainting, chest pains, dizziness, headache and tremors. Prevagen might not be recommended for someone with a history of those symptoms. Please consult your physician for more information.

  • Marshall Van Meter

    Prevagen is reportedly a protein extracted from jellyfish that improves brainpower. If you swallow one of these pills, the gastrointestinal tract will take this protein, break it up into its constituent amino acids, then absorb them, then the body will use the amino acids to build whatever proteins it feels it needs, not the original protein. If you are buying these pills at approximately $1.33 for 10 mg, you are paying approximately $6000 a pound for a protein supplement. Whey protein purchased at Wal-Mart or the general nutrition store is a much better buy!

    • Brian Lawliss

      Is this person a Doctor? Or a Walmart Sales Assoc?

      • Your Name

        That’s kinda what I wanna know lml

    • Jesse

      Marshal, while I was initially enthused about Prevagen I was becoming less so between the review article and the comments. Like the others said, they wondered if you were a Walmart employee. Laying that aside, you did give an option for comparison. Whey. I’ve been using that for some time because protein is supposed to help with type 2 diabetes, as I understand it. I think everyone who visits this page could help each other by researching this more and sharing their thoughts. That’s what I’m going to do.

  • How to get this?
    howard brinton

    how do i order

    • Jessica (Editor)

      Hi Howard. For ordering information, please refer to the Prevagen official website.

  • Any suggestions where I can request
    Bertha Podwys (Verified User)

    I am 92 and my problem was my short memory about dates, or remembering things going from one room to another. I decided to try Prevagen Feb 1,2015. I feel that it does help my short memory. I will know more after I have my regular Dr. check up this year, who should notice a difference in my vision or when I get my regular blood check up. Do you have any suggestions that I could request on my blood check up, like calcium or etc.???Appreciate your response.

    • Jessica (Editor)

      Hello Bertha. Please take the product with you to your appointment and advise your physician that you are taking it. They should be able to provide you with what you should request at your check up.

  • suffer from ADHD
    robbin rfrazier

    I would like to know if this product has been tested on children that suffer from ADHD? Is it safe for children; would you recommend this product for children?

  •  Stroke and Heart Attack Warnings
    Deb (Verified User)

    I started taking Prevagen 35 days ago. My 83 year old mom has Dementia, I’m 60 and have been experiencing memory loss myself. I decided to try it after seeing your commercial and reading about it on the web. The first week I noticed a few changes. The second week I could recall dates and info more rapidly. The third week I remembered a phone number 6 days after hearing it only once in my life. The fourth week I felt younger, more focused, on task, I felt like this 60 year old was 25 again. It is a great feeling. I am worried about the stroke and heart attack warnings. I would like yo know how many people have experienced adverse effects in any way but especially stroke, seizures, heart attacks. My family doesn’t want me taking it because of the warnings. I don’t want to stop feeling like i’m 25 again. Please advise.

    • Sarah (Editor)

      Hello Deb. Some dieters claimed to have experienced the effects of high blood pressure, fast heartbeat, fainting, chest pains, dizziness, headache and tremors. Please consult your physician if Prevagen is something you want to keep taking.

  • prevagent induce seizure on an epileptic person
    Jose lopez

    Can prevagent induce seizure on an epileptic person

    • Sarah

      Hello, Jose. For questions on effects with epilepsy and seizures, please ask your physician.

  • How long it took for me to notice a change?
    Todd (Verified User)

    By the second month of taking it I noticed Prevagen having some effect. It wasn’t like a lightning bolt and suddenly I rememebered everything better but there has been a definite increase in sharpness with my ability to pull up words when I was taking to someone. I was hoping it would work faster and I was hestitating on a second bottle but that’s how long it took for me to notice a change.

    • Jessica (Editor)

      Hi Todd, thanks for the feedback!

  •  Prevagen has helped my memory tremendously.
    Glenn (Verified User)

    Prevagen has helped my memory tremendously. I had to take the stronger dosage and it helped me remember names, facts at work, etc. I am 74 years old.

    • Sarah (Editor)

      Hello Glenn, thanks for the feedback!

  •  This product doesn't work for me.
    Bill Case (Verified User)

    I am 87 year old man that is physically and mentally degraded to some extent. I have been taking Prevagen Extra Strength for many months. I have continued to lose my memory! Has Prevagen helped? Who knows? Actually, I now think it is a VERY expensive product with really no actual proof of effectiveness. My wife is three years younger, and has very similar memory problems. She DOES NOT take the Prevagen and seems to have about the same memory problems that I have. Of course that is not proof of anything, but it does NOT verify that Pregagen is so very effective!

    • Mark

      It is likely that you have a fungus outbreak that is causing your mental decline, thereby over-riding the benefits of Prevagen. I recommend that you treat for fungus by implementing the Phase-one diet (search “Know the cause” by Doug Kaufman) then attack the fungus with anti-fungal foods and supplements.

  •  Loved the product.
    Laurue (Verified User)

    After seeing the amazing results in a friend, I asked her what she was taking and she told me about Prevagen. I had not seen her that Sharp in years! I have been taking it for about two months and have noticed a BIG difference in my cognitive ability and my memory. And, it didn’t take but one week to notice the difference. My recommendation is to buy one bottle and see for yourself – my guess is you will continue to take it. I’ve tried Omega 3’s and various fish oils and never noticed a difference. But, this product really works! My job performance has increase tremendously. Can’t say enough…even have my husband taking it now.

    • Helen

      I am interested in this product and was wondering what age Laurue is as i noticed the more negative responses were those who were older. i am in my 50’s. That may make a difference at what point u start using this. the younger the better result? just wondering.

      • Phil

        Hi Helen! I’m 63 and when I started trying Prevegen, I noticed a quicker recall in three days. My wife is 48 and she noticed a difference after 1 week. My favorite Aunt, who is 78 tried it and after 3 weeks, noticed the same effect that I had. It is absolutely worth a try. The the only thing you have to lose is a bad memory!

  •  Loved the product.
    Patricia (Verified User)

    My good friend started taking Prevagen a few months ago and has had a small miracle happen. She had a poor memory, and some learning disabilities that became embarrassing at her fast-paced job, but since taking it, she has noticed a huge difference. She feels so amazed by the results, she gave me a bottle. it is helping me with my post ‘chemo-brain’ fog. So much so that I splurged on a 3 month supply! I don’t go in easily for these sort of things, and sincerely don’t believe my success is the result of some placebo effect. I feel clearer in my thinking, my memory has improved, and you can’t make this stuff up!

    • Your Name

      This comment seemed helpful

  • Will it be harmful for health?
    Anne Wyckoff


    While I’ve had the same concerns as you (+17 years of medical study involving pathology), there IS something odd happening to some consumers. I, for one, am very immune to the “placebo effect,” yet after trying this for 2 weeks, I suddenly woke up with name-recall. My son noticed this, because I had to ask him names constantly in the past. I wouldn’t have tried prevagen if I’d looked into the molecular structure first, however (a rare lapse in judgement)
    Do you think there’s a possibility that the EDTA is chelating something harmful with some people? I noticed another positive review from a scientist who used it for a trial but then stopped. It bewildered him as it does me.

  • Product is quite expensive for me
    Nadine Anderton

    I always suspect nutritional supplements that come from exotic (like jellyfish) sources rather than from food-obtained nutrition. This allows the makers and distributors to make big bucks – something like the pharmaceutical companies? It sounds good, but it totally unavailable to someone like me on a very limited income. So I guess I’ll just have to die from my brain problems, which may or may not turn out to be Alzheimers.

  • Information about amino acid effects

    Amino acids cross the blood-brain barrier. Whole proteins do not. Any beneficial effect of apoaequorin is lost as soon as it is digested into amino acids like any other protein. It is simply untrue to claim that apoaequorin taken orally has any effect in the brain whatsoever.

    • Joyce

      Have you actually taken it?

  • Questions about amino acids
    JK Freeze

    Jason says “Disregarding the sketchy clinical trials cited, the active ingredient is a protein compound (Aequorin) that gets broken down upon digestion into its component amino acids. While Aequorin certainly does bind calcium, even if it did survive digestion it is unlikely to pass the blood-brain barrier”

    Jason, being a bio-chemist, you DO know that ALL amino acids pass the blood brain barrier, don’t you?

    also, Prevagen does NOT contain EDTA.

    • Ed B

      Check the label…it has EDTA

  • Feeling worse
    sherry oglesby (Verified User)

    seem to feel worse on this my thinking isworseand ihave an increasted bp
    what do others say

  • Prevagen experience
    Joy zuer (Verified User)

    Thank you for the reviews. Upon taking prevagen, lots of energy, could stay focused, but could not sleep on this product. Independent studies would make it morally sound. Don’t you think?

  • Need more information about calcium metabolism

    How does it affect Calcium metabolism in bones? Jellyfish don’t have bones!

    • BC

      Good point Mary

  • anzhaime
    Maria Steiselboin

    A person with advance diseace like anzhaime this can help, or is too late?

  • anzhaimer
    Maria Steiselboin

    A person with anzhaimer deseace in advance state this can help? because she can’t talk o walk?

  • emily

    could this supplement help migraine headache or headache pain?

  • can you lose weight from it ?

    Since it is a dietary supplement,can’t you lose weight from it ?