You may be surprised by what I say in this Prevagen review. We at DietSpotlight dug deep into the ingredients, side effects, and scientific studies. Plus, we took a close look at hundreds of customer comments. Then, we summarized the facts to give you the info you need.
What is Prevagen?
First off, Prevagen is an over-the-counter dietary supplement containing the active ingredient Apoaequorin.  Take one each morning and it supposedly improves memory, promotes clearer thinking and a sharper mind.  The product doesn’t contain synthetics – impressive.
Prevagen was first introduced in 2007 by Quincy Bioscience. Although it’s not sold on the official website, several trusted retailers have it on the shelves. We like the longevity of the company and that we located some favorable customer comments, but read on…
Prevagen Side Effects – “Concerning?”
The first thing that concerned us were reports of Prevagen side effects.  “We read one review after another with claims of negative reactions,” says our Research Editor. “That’s not what the customer is looking for.”
One user complained, “Developed heart flutter about 75 days after I started taking this.”
“Upon taking my first Prevagen, within a half hour I became light headed and dizzy and my focus was worse than ever the rest of the day,” commented one user.
Another person said, “I don’t have high blood pressure and it made my blood pressure go up.”
User Complaints – “Another Concern”
Numerous customer complaints are posted online concerning Prevagen. One user stated, “I had a reversal of memory while taking this product. Many instances where I forgot peoples’ names in public situations.” 
Another customer said, “I took the Prevagen 10mg pills for 30 days and I honestly don’t notice any difference. Don’t waste your money on this.”
There are some users who saw positive results. 
“The change was subtle to begin with but has suddenly became more noticeable by the 4th month,” said one person.
Some felt the results were good, but the price was a little over the top. 
“I have taken this product with positive results but I think it is too expensive,” offered up one user.
The extensive research we’ve done has revealed if there is a particular facet of a dietary supplement that’s concerning, such as too many user complaint, the probability of long-term success is low. If Prevagen does cause reactions in users, this could be a serious problem.
The Science – “Is it Legit?”
There are some studies presented on the official website that pertain to Apoaequorin, the active ingredient in Prevagen. While this is good to see, there’s no proof this product relates to weight-loss. Also, the FDA had to issue a warning about this product because it can lead to side effects.  At DietSpotlight, research is imperative. If the science doesn’t back the claims or support you losing weight, we raise the red flag.Also: read our Leptigen Weight-Loss Kit review »
The Bottom Line – Does Prevagen Work?
So, should you race out to buy Prevagen? Well, we like that Prevagen is easy to find and that we found, but the research not pointing toward weight-loss leaves us concerned. Furthermore, we have some issues with the numerous customer complaints, especially relating to adverse effects. 
Do you want to lose weight and improve wellness? Consider combining Prevagen with a supplement containing clinically-tested ingredients shown to help with weight-loss.
Among the best products we’ve seen this year is one called Leptigen. This supplement contains clinically-tested ingredients, which have been shown to help boost metabolism and accelerate fat loss. We have not found any talk of harmful side effects and user comments indicate people are seeing substantial results.
The makers of Leptigen are so confident in their product they’re offering a Special Trial Offer, which is a good sign.
Previous Prevagen Review (Updated June 16, 2014):
What You Should Know about PrevagenThe brain protects its cells from degradation by generating a protein that regulates cellular calcium. If calcium increases in cells, they will be destroyed. With the natural aging process, the body generates that protein in lesser amounts. Prevagen is a supplement that promotes the better health of the brain and its functions, in much the same way Focus Factor does. The product focuses on improving memory loss and protecting the brain by supplying it with a protein called apoaequorin. This protein belongs to a family of molecules that binds calcium. Prevagen can easily be bought from health food stores as well Rite Aid stores. However, the website’s online shopping page allows interested clientele to purchase the amount they want.
List of Prevagen IngredientsThe only ingredient that is mentioned on the website is the apoaequorin protein, which is extracted from jellyfish. Even the concentration of that protein isn’t mentioned in the Prevagen material.
Product FeaturesPrevagen claims to bind calcium in cells, thus reducing the damage which occurs when the body doesn’t produce many calcium binding proteins as it ages. Prevagen, like Vibra Slim, is designed for people 40 and older. The apoaequorin protein, which was discovered in the early sixties, is apparently responsible for the whole calcium binding process. Prevagen, along with Ambislim PM, also promotes restful sleep. This effect is a double-sided coin, as we discuss on our Prevagen Side Effects review The research conducted by the supplement’s developers supposedly demonstrated that the apoaequorin protein mainly benefits consumers by enhancing their mental clarity, honing their decision-making skills, improving their memory and helping them focus. This affect on the brain is similar to how the leptin in Leptinal impedes the hunger signals in your brain. However, these claims haven’t been confirmed by the FDA. Still, the website promises consumers positive results between periods of use from 30 and 90 days. Aside from that, the product has been approved to be kosher by two of the four main production facilities in the United States.
Advantages of Prevagen
- The website does offer supporting evidence regarding Prevagen’s effects on memory and sleep.
- An informative video explains how the supplements will enhance the brain’s functionalities.
- The website directly states that it hasn’t been FDA approved, thus spares consumers the time and effort of trying to locate the FDA approval stamp.
Disadvantages of Prevagen
- The product isn’t FDA approved. Although the website was truthful enough to mention this fact, it still isn’t a favorable factor.
- There are no indications regarding Prevagen being free from side effects.
- The supporting studies were limited studies, not full-scale ones.
- The evidence supporting the product is mainly anecdotal and not quantitative.
ConclusionAge does affect the body in various ways, and the brain is no exception. Age has a very taxing affect on the body and mind; numerous products including Nature's Pearl try to tackle this. If Prevagen is really as good as it claims to be, people will really benefit immensely. However, with the supplement’s shortcomings, caution should be taken prior to its consumption.
Prevagen Questions & Answers:
We summarized hundreds of user comments about Prevagen into this helpful FAQ.
What are the side effects of Prevagen?
Some potential side effects of Prevagen include heart arrhythmia , fainting, tremors and chest pains; based on customer reviews.
What is in Prevagen?
Prevagen ingredients are apoaequorin, white rice flour, sodium chloride, magnesium stearate and acetic acid.
What is the active ingredient in Prevagen?
The active ingredient in Prevagen is apoaequorin.
Does Prevagen work?
There is scientific research proving Prevagen is effective for improving memory. Unfortunately, there’s no studies linking the ingredients to weight-loss.
How much does a bottle of Prevagen cost?
A bottle of Prevagen costs $59.95. If you buy two bottles, the price increases to $119.90. Three runs $239.80 and eight is $479.60. You receive a discount on multiple bottle purchases.
How do you take Prevagen?
You take one Prevagen capsule in the morning with or without food. One bottle lasts 30 days.
Can I take Prevagen if I have a health condition?
Woman who are pregnant or nursing, anyone taking prescription medications, people with health conditions or anyone under 18 years of age should consult a healthcare provider prior to using any supplement, including Prevagen.
What do users like about Prevagen?
Some users like the affordability of Prevagen and that they receive a discount on multiple bottle purchases.
What do users NOT like about Prevagen?
We found that some Prevagen users don’t like the side effects associated with the supplement.
Who makes Prevagen?
Quincy Bioscience makes Prevagen.
How do I contact the Prevagen customer service department?
You can contact the Prevagen customer service department by mailing correspondence to Quincy Bioscience 301 S. Westfield Rd. Madison, WI 53717, emailing a representative at email@example.com or calling 1- 855-331-7721.
Can I contact Prevagen through social media?
What is the main ingredient in Prevagen?
The main ingredient in Prevagen is apoaequorin. This is found in certain species of jellyfish. 
Do I have to diet and exercise on Prevagen?
No, you don’t have to diet or exercise on Prevagen, but the official website recommends adding healthy eating and fitness to any supplementation.
Can I purchase Prevagen at local stores?
Yes, you can purchase Prevagen at local retailers. You may not receive the multiple bottle discounts.
Has the Food and Drug Administration contacted the makers of Prevagen?
Yes, the FDA sent letters to Quincy Bioscience Manufacturing relating to mislabeling of the supplement and claims made by the company.
Is there a guarantee with Prevagen?
Yes, there’s a guarantee with Prevagen. You can return any portion of the supplement for a complete refund of your money within 30 days.
Do you know of any special deals or discounts on Prevagen?
The only discounts and special deals on Prevagen include savings if you order multiple bottles. However, our readers have been going wild over the past few months taking advantage of the Special Trial Offer from Leptigen. Click above to learn more.
Prevagen Scientific Abstracts:
Neurons from OGD were dose-dependently shielded by apoaequorin. At doses of 1% and 4%, there was a significant reduction in number of trypan blue-labeled neurons. This time dependent effect lasted 48 hours. This effect had been mirrored by alterations in chemokine and cytokine expression, suggesting that apoaequorin could shield neurons through a neuroimmunomodulatory mechanism. This data reveals that pretreatments with apoaequorin will indeed protect neurons from ischemic cell death, and could be an effective neurotherapeutic. 
The study was put into place to discover if there had been adverse effects to apoaequorin in rats, after subchronic administration. The results had shown NOAEL (No Observed-Adverse-Effect Level) for apoaequorin was at 666.7 mg/kg bw/day tested at the highest dose. There had not been any mortality resulting from administration of apoaequorin. There had been no signs of body weight gain, food efficiency, food consumption, histopathological, or clinical pathology differences which could point toward apoaequorin administration. 
Data was compiled from perspective and cohort studies showing the Asian populations having much higher rice ingestion levels than the West (average intake was three to four servings per day vs. one to two servings per week). Pooled relative risk was at 1.55 (95% CI 1.20 to 2.01) when weighing the highest and the lowest white rice consumption in Asian populations, and the comparable relative risk was at 1.12 (0.94 to 1.33) in the West (P for interaction=0.038). Dose response meta-analysis suggested for each serving of white rice per day the risk of type-2 diabetes was at 1.11 (1.08 to 1.14) (P for linear trend<0.001). It had been concluded that the higher intakes of white rice was accompanied with a higher risk of type-2 diabetes. 
There were 10 participants, all with type-1 diabetes and diabetic gastroparesis, included in the double blind trial. GER (gastric emptying rate) was measured with real time ultrasonography. The gastric emptying rate was then calculated as percentage differences in the antral cross-sectional area 15 and 90 minutes following consumption of 200ml of water and 300g rice pudding, or 200ml of water along with 30ml apple cider vinegar. The participants had ingested 200ml of water per day (GER1) prior to breakfast. The same participants had then ingested 200ml of water with 30ml of vinegar per day (GER2) prior to breakfast for a length of two week prior to measurements. In conclusion, the median values of GER 1 and 2 were both at 27% and 17% respectively. The activities of vinegar on GER were extremely significant (p < 0.05). 
- 1. Pretreatment with Apoaequorin Protects Hippocampal CA1 Neurons from Oxygen-Glucose Deprivation (2013). PLoS One. November 5, 2016.
- 2. Safety Assessment Study of Apoaequorin Published in Food and Chemical Toxicology (2013). ScienceDirect. November 5, 2016.
- 3. White rice consumption and risk of type 2 diabetes: meta-analysis and systematic review (2012). TheBMJ. November 5, 2016.
- 4. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study (2007). BMC Gastroenterology. November 5, 2016.
Prevagen Side Effects:
While natural weight-loss supplements may seem like the safer option, they still come with risk. With every formula, there is the potential for a negative reaction. Though Prevagen side effects are rather uncommon, that doesn’t mean they don’t exist for some users.
Syncope or fainting is a sudden loss of consciousness for a brief amount of time. It may come from a sick feeling and often nausea is associated with fainting. Some injuries may be caused by fainting, since the person usually falls to the ground suddenly.
What causes fainting?
Fainting may be caused by a number of different conditions. It may be caused by heart issues, low blood sugar, anemia, seizures, irregular heartbeats, nervous system issues, genetic issues and certain medications.  Usually, fainting only lasts a few minutes.
Any pain felt in the chest may be described as a chest pain. Not all chest pains are heart related. A momentary chest discomfort may be felt or the discomfort may only be associated with breathing. Some types of chest pain actually get better with exercise, as well.
What causes chest pains?
While a heart attack is the most common cause of chest pains, it’s not the only cause. Chest pain may also be caused by angina, aortic dissection, pericarditis, heartburn, gallbladder issues, sore muscles, injured ribs, a panic attack, shingles, pulmonary embolism, collapsed lung or pleurisy.  Even some medications and supplements may cause chest pain.
An involuntary quivering movement is known as tremors. This movement may be rhythmic and may feel like a to-and-fro type of movement. Often, tremors affect the arms, hands, face, voice, legs and head. Most commonly, tremors occur in the hands.
What causes tremors?
Tremors may be caused by many different health issues including Parkinson’s disease, liver failure or alcoholism. You may also experience tremors if you suffer from arsenic poisoning or mercury poisoning. Tremors are a common side effect of antidepressants, other medications and some supplements.
Any problem with your heart rhythm is known as heart arrhythmia. This happens when the electrical impulses coordinating your heartbeats are not working correctly. It may feel like a racing heart beat or like your heart is fluttering.
What causes heart arrhythmia?
While some of the causes of heart arrhythmia are harmless, some are very serious. An electrolyte imbalance in the blood may cause an arrhythmia, while a more serious cause is coronary artery disease. Changes in blood pressure may also cause heart arrhythmia, along with some medications and supplements.
Prevagen side effects are rare, but reports of fainting, chest pains, tremors, heart arrhythmia and other reactions have surfaced from some users. To ensure your protection, always speak with a doctor before starting a new supplement, especially if you’re already taking medication, suffer from a medical condition, you’re pregnant, nursing or you’re under the age of 18.
One that’s caught our eye is Leptigen. There’s no talk of harmful side effects and it’s backed by positive customer reviews.
There comes a time when we come across a product needing more attention, like Prevagen. This time we decided to concentrate on Prevagen side effects. We delved into ingredients, clinical research and customer comments. We then refined that info to give you the bottom line.
What You Need to Know
Prevagen is dietary supplement containing the protein apoaequorin. The recommended serving size is one capsule per day, which supposedly improves brain functionality. There is limited information linking it to weight-loss. One of the benefits of the product is that it’s easy to use.
Prevagen was first introduced by Quincy Bioscience in 2007. The website states the key ingredient was discovered and developed in 1962. The supplement doesn’t appear to include synthetics, a good decision. You can purchase the product directly from the company and through other online stores. We do like that the business has a history in the industry and the favorable BBB rating, but read on…
The first concern we had with Prevagen side effects was that dieters felt drowsy. “When a company claims a supplement is supposed to improve brain functionality, no one expects to feel off after taking it,” offers our Research Editor. “It looks like this one may affect the user a little too much.”
“I felt like I was drugged. It made me so lethargic and foggy, I had to lie down, where I then slept for 3 hours. Even after getting up, I was still very, very brain-foggy. Very scary feeling. It’s now a week later and although the druggy feeling is subsiding a little, it is still very much present” reported a user.
“I tried taking it now for three days and have been depressed, foggy, irritable, and fatigued,” said a customer.
“I too, have had to lay down and have slept for a couple of hours, but still feel drugged and foggy. I am also getting a headache,” commented a dieter.
In October of 2012, Quincy Bioscience was contacted by the Food and Drug Administration about Prevagen. The company was cited for marketing the supplement as a drug and multiple customers had experienced severe side effects. Plus, the FDA reported that,” Prevagen, Prevagen Extra Strength, and Prevagen Professional products are not generally recognized as safe and effective.”
Heart Rate Increases
Customers commenting on Prevagen side effects said the product increased their heart rate. Several stated that they didn’t add anything to their diet except the supplement. “I could only take it for 7days because it gave me heart palpitations starting on the second day. I continued to take it as instructed because I thought maybe the palpitations would subside, but they didn’t,” said a user.
“Two months ago my blood pressure all of a sudden sky rocket to 172/100. I had made no changes whatsoever, I do not take any medication except vitamins,” reports a consumer.
“I was at work and had stroke like symptoms. The only change I had in my routine was that I started taking Prevagen a few weeks earlier,” commented another.
Our research has shown that if any part of a dietary supplement causes concern, like adverse side effects, it could inhibit chances of long-term success. If the reports about Prevagen side effects are true, this could be a problem.
The official website says the supplement is “scientifically proven,” but we couldn’t locate published clinical research supporting the claims. Even the FDA couldn’t locate science to back the company up. At DietSpotlight, locating research linking a formula to the benefits is critical. If there’s no proof it works, why bother?
The Bottom Line
After taking a close look as Prevagen side effects, we’ve come to a solid conclusion. We noticed some positives, like the length of time the company has been in business and the favorable BBB rating, but we can’t recommend it because of the lack of scientific research linking the formula to weight-loss. Plus, we’re concerned about the FDA warning letters and the noted adverse reactions.
If you’d like to transform your body, we recommend a supplement without negative side effects that’s backed by published clinical research.
One of the best supplements we’ve seen in 2016 is one called Leptigen. The product consists of a formula containing a four-ingredient proprietary blend, which has been shown in published scientific studies to accelerate metabolism and ignite fat loss. There’s no mention of negative side effects and consumer comments show people are seeing excellent results.
Also, the company that makes Leptigen are so confident in the product, they’re providing a Special Trial Offer, a good choice.
Prevagen is a supplement formulated to improve or support memory. There is science behind the ingredient they've chosen and while there is no connection to weight-loss, if this is an issue you're dealing with it may be a good option.
Prevagen Ingredients and Supplement Facts
Serving Per Container: 30
|Amount per Serving||% DV|
|Prevagen Regular Strength||*||*|
|Prevagen Extra Strength||*||*|
Other Ingredients: Microcrystalline cellulose, vegetable capsule, salt, vegetable sourced magnesium stearate
We examined the Prevagen ingredients in order to give you the facts you want.
Apoaequorin is a protein derived from glowing jellyfish . It has become a popular ingredient in some dietary supplements for weight-loss.
What Is It Supposed To Do?
Apoaequorin is consumed to treat memory, mental function, and sleep quality.
When the safety of apoaequorin  was tested, researchers concluded, “Based on the results of this study, the No Observed-Adverse-Effect Level (NOAEL) for Apoaequorin was determined as 666.7 mg/kg bw/day, the highest dose tested.” This study was published in Food And Chemical Toxicology : An International Journal Published For The British Industrial Biological Research Association. Nothing was noted for its ability to induce weight-loss.
White Rice Flour
White rice flour is made from milled rice. It is sometimes used as a replacement for wheat flour for those who are gluten intolerant.
What Is It Supposed To Do?
White rice flour contains dietary fiber and protein, which can be beneficial to general organ health. It also contains vitamins and nutrients like calcium and zinc.
According to Arya Atherosclerosis, “Although there was no significant association between white rice intake and obesity factors in our study, more studies are necessary with larger population and better design.” Nothing was stated about white rice flour.
Acetic acid is the main chemical found in vinegar. It is typically manufactured in the United States, Europe, and Japan. It is sometimes used in physical therapy.
What Is It Supposed To Do?
Acetic acid is sometimes used to treat ear infections, head lice, nail fungus, and impetigo.
According to a study published in Bioscience, Biotechnology, and Biochemistry, “In conclusion, daily intake of vinegar [the source of acetic acid] might be useful in the prevention of metabolic syndrome by reducing obesity.” No studies were available concerning its individual connection to weight-loss.
One that’s on our radar is one called Leptigen. It contains clinically-tested ingredients shown to help boost metabolism and ignite fat loss.