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CholestOff Review - 10 Things You Need to Know

CholestOff by Nature Made is a dietary supplement that claims to “lower blood cholesterol levels.” According to the company behind it, CholestOff “contains active ingredients that block your body’s absorption of cholesterol while improving your cardiovascular health.” CholestOff is neither a remedy for someone with a medical condition nor a weight loss pill – it is merely a preventative supplement.

We wanted our research team to investigate the use of CholestOff in clinical studies to see if it has long-term benefits. So, we looked into the science behind to product to give you the Bottom Line. Read on to learn what we found.

CholestOff can be purchased through their Official Site.

CholestOff Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is CholestOff?

CholestOff is a nonprescriptive, dietary supplement that claims to “lower the levels of blood cholesterol.” The supplement is also widely prescribed as an enhancement for cardiovascular health and wellbeing.

Nature Made or Pharmavite, LLC is a California-based manufacturer of dietary supplements, multivitamins, and herbal supplements. There is a Better Business Bureau (BBB) page for Pharmavite, LLC but it is not rated yet. Other brands offered by Pharmavite LLC include Equelle, MegaFood, Nurish, and Uqora.

According to Nature Made, CholestOff uses a proprietary blend of plant stanols and sterols called Reducol, a tasteless, odorless ingredient that they state “works as a catalyst that blocks the absorption of cholesterol in the gut.”

Reducol is also a popular ingredient in the manufacture of dietary supplements and fatty and nonfat functional foods. The naturally occurring plant sterols and stanols are present in leaves, vegetables, and nuts of various plants.

Through decades of research, plant sterols and stanols have been useful as a critical ingredient in supplements and drugs.

One serving of CholestOff supplies 0.9g of sterols and stanols in capsule form. Users of CholestOff should consult their physicians as part of the cholesterol management program.

A complete regimen encompasses regular checks of cholesterol levels, a healthy diet, physical exercise, and body weight management.

What does the research have to say about the Reducol component?

  • Journal of Agricultural and Food Chemistry – “Phytostanyl fatty acid esters, which are being added to a variety of foods owing to their cholesterol-lowering properties, are susceptible to thermally induced oxidation reactions.” Such fatty acid esters are found in ingredients like Reducol.
  • National Library of Medicine – You can even add Reducol to plant-sterol enriched milk for positive results on cholesterol levels.
  • Journal of Oleo Science – A direct look into plant sterols in other research again shows a promising impact on cholesterol.

CholestOff Competitors

Cardio Cuts

Customer Service Contact Information

  • Address: 8531 Fallbrook Ave., West Hills, CA 91304
  • Mail: P.O. Box 8531 West Hills, CA 91309-9903
  • Phone: 1-800-276-2878 toll-free Monday – Friday, 8 am to 2 pm (Pacific Time)
  • Contact form: https://www.naturemade.com/pages/contact-us
  • Email: info@naturemade.com

Refund Policy

If you are not completely satisfied with your product, you may request a refund of your payment (less any applicable shipping fees) or a replacement within 30 days of receipt.


What is Cholesterol?

To learn and appreciate the benefits of CholestOff, it is crucial to understand what cholesterol is.

Blood cholesterol is crucial for making hormones and digesting food. However, having too much cholesterol can have effects on your health

According to Nature Made, “CholestOff lowers the level of LDL and Non-LDL cholesterol.” Though Nutrients also note their potential benefits, larger and more comprehensive studies are needed to confirm these findings.

The National Institutes of Health (NIH) advises people who want to manage their cholesterol levels to decrease their dietary intake of saturated fats, trans fat, and cholesterol.

Sterols Vs. Stanols

Sterols and stanols sound an awful lot alike; there are similarities and differences. On a molecular level, both look similar to cholesterol. You can find both in foods, but some companies understand sterols and stanols benefit health, according to the Journal of AOAC International.


CholestOff Ingredients

The active ingredients in CholestOff, are sourced from natural plants such as the pine tree.

The foods with high concentrations of fortified stanols and sterols include granola bars, yogurt, margarine, and orange juice.

Regarding this dietary supplement, four caplets of CholestOff can deliver up to 1.8g of sterols and stanols.

According to the instructions, CholestOff contains no artificial flavors, gluten, preservatives, or yeast. Besides plant sterols and stanols, other ingredients include:

  • Plant Sterols/ Stanols (Pine Tree)
  • Cellulose Gel
  • Polyethylene Glycol
  • Calcium Carbonate
  • Triethyl Citrate
  • Polysorbate 80
  • Tribasic Calcium Phosphate
  • Silicon Dioxide
  • Hydroxypropyl Methylcellulose
  • Croscarmellose Sodium
  • Magnesium Stearate

Hydroxypropyl Methylcellulose is a coating agent many pharmaceutical companies use. While Croscarmellose sodium and Polysorbate 80 works as an emulsifier.

Magnesium stearate is a standard white substance used in the manufacture of some diet pills.

Silicon dioxide helps absorb moisture and is considered an anticaking agent.

Polythene glycol is a popular polyether compound in several medications, while Triethyl citrate is a colorless and odorless liquid that helps stabilize foams. The ingredient is also used by pharmaceutical companies for coating purposes.

Supplements such as CholestOff should not be taken to treat health issues. For this reason, patients are advised to consult the doctor before taking any dietary supplements.

Does CholestOff Work?

Does CholestOff Work?

Some research supports the effectiveness of CholestOff in its claims of reducing blood cholesterol levels. According to the International Journal of Food Sciences and Nutrition, supplementation with a dietary supplement containing plant sterols/stanols reduced the total cholesterol by 2.8%, LDL cholesterol by 4.9%, and non-HDL cholesterol 3.6%.

Most of the reviews concerning CholestOff on sites like Amazon.com are positive.

Sterols are widely available in natural foods such as grains, vegetables, and fruits.

Side Effects

CholestOff Side Effects

There’s no mention of side effects from CholestOff. However, taking CholestOff products are not recommended for children, pregnant or lactating mothers. Restrictions also apply to people with certain medical conditions and those allergic to pine trees and constituent products.


CholestOff Directions

The recommended serving of CholestOff for high cholesterol and other natural support is two capsules, two times a day, which equals a 1,800 mg dosage. The CholestOff Original contains 60 to 120 caplets, depending on the container size.

The supplement is best before meals; Nature Made recommends taking between 15 to 30 minutes before mealtime.

To better swallow the pills, you can drink water before and during consumption.

Where To Buy

Where to Buy CholestOff?

CholestOff Complete Softgels is available on the official website, the 120 softgels bottle cost $42.69.

There is also a location finder on the official website if you would like to purchase the supplement at a store near you.

CholestOff prices range heavily based on where you buy it. For example, a 120 softgels count bottle costs about $38.86 on iHerb.

What Users Are Saying

What Users Are Saying

“This product dropped my cholesterol by 10 points in about a month. Probably would have been lower if I didn’t eat ice cream every other day.”

“I tried it for 2 months and my LDL level actually went up. And I diet and exercise. Just doesn’t work.”

“I had high hopes for this product to lower my genetic cholesterol but it really upset my stomach. (I’ve had this problem with other meds too.) I took only 2 pills per day for about 10 days and the heartburn and indigestion got progressively worse. I did read that this happens in a few cases.”

Bottom Line

The Bottom Line on CholestOff

While many supplements marketed for their ability to lower levels of cholesterol show promise, a few others are neither strong nor effective in lowering the levels of cholesterol.

The results obtained from people using CholestOff can vary, depending on whether the individual has a history of heart conditions, preexistence medical condition, nursing or pregnant.

Before taking CholestOff for weight loss, it is important to understand that there are diet pills, supplements and support programs on the market that are more effective for weight loss.

If you’re looking to improve overall health and increase weight-loss, we suggest going with a program that provides more bang for your buck and scientific evidence that proves it works.

Among the best products we’ve seen this year is one called Noom. The clinically-tested program works to help you lose weight and keep it off. It’s likely the unique approach to weight loss that makes the program successful. You get personalized meal plans, human coaching and much more that you don’t find in other apps.

Also, the makers of Noom are offering customers a free trial offer, which is a sign of confidence in their product.

Learn More About Noom »
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What are the side effects of CholestOff?

CholestOff side effects could include bloating, indigestion, gas, and stomach pain.

What are the ingredients in CholestOff?

CholestOff ingredients are Plant Sterols/Stanols (Pine Tree), Calcium Carbonate, Tribasic Calcium Phosphate, Croscarmellose Sodium, Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate, Color Added, Polyethylene Glycol, Triethyl Citrate, Polysorbate 80, and Sodium Citrate.

Does CholestOff work?

There are no ingredients in CholestOff that work to increase weight-loss.

How much does CholestOff cost?

For a one-time purchase, you can buy it for about $13.00.

How should I take CholestOff?

You should take two capsules two times a day.

Where can I buy CholestOff?

CholestOff can be purchased using their Official Site.

Can I take CholestOff if I have a health condition?

You should ask your physician if you have health problems, are under the age of 18, pregnant, nursing, or are taking prescriptions.

What company is behind CholestOff?

Nature Made is the company behind CholestOff.

Does CholestOff contain yeast?

No, CholestOff doesn’t contain yeast, starch, preservatives, synthetic dyes, or gluten.

Do you know of any special deals or discounts on CholestOff?

There are deals and discounts, if you subscribe to get CholestOff once every one to six months; you can save between 5% and 15%.

If you’re looking to lose weight, you may want to look at Dietspotlight Burn’s special trial offer. Users are going crazy over the deal because it’s only the cost of shipping and handling. Click here to check it out!

What is CholestOff plus?

Good heart health requires healthy cholesterol levels. CholestOff® Plus is formulated with Reducol. This is a proprietary formula of plant stanols and sterols. These reduce the absorption and release of dietary cholesterol into the bloodstream and have been shown to lower LDL (“bad”) cholesterol.

What is Cholestoff used for?

A dietary formula containing the proprietary phytosterol blends Reducol™ and Pantesin, Nature Made CholestOff® Complete works to lower LDL cholesterol. The plant sterols and stanols inhibit the absorption of cholesterol consumed through the diet.

96 CholestOff Reviews

  • Product really works
    Latonya (Verified Purchase)

    My particle cholesterol level went from 2847 to 2532 in 6 weeks. A little over a year it was 1450. My calculated cholesterol went from over 200 to 145. Those are two types of cholesterol tests. The particle is more accurate. Cholestoff works! The biggest diet change I made was decreasing my ice cream intake.

  • Product works for me
    Latonya (Verified Purchase)

    I took this product for a little over a year. My cholesterol went from 2832 to 1450. This is from a particle lipid test, not calculated. Most people have the calculated test, whereas your number should be below 200. A particle test is more accurate. You can have a normal calculated test, but particle shows the truth. Cholestoff works!

  • It's not cheap
    Matt (Verified Purchase)

    It’s not cheap

    • Edward Bond

      U are soooo correct

    • Dustin

      Yes it’s not but is it worth it for a healthier life? I do believe it is probably better and safer for you.

  • Does Cholestoff contain anything that could be bad for the heart?
    Roberta (Verified Purchase)

    I have been taking Cholestoff for several weeks, and I developed heart palpitations during this time. Not sure if they’re connected. Has anyone else had this experience? Does Cholestoff contain anything that could be bad for the heart?

    • judy

      I been taking Cholestoff for nearly a month and until i read that you were having palpations i couldnt figure out why my heart was beating differently almost like its racing i will stop taking cholestoff. Did your palpations stop after discontinuing it.

      • Linda

        I went online today to look up the side effects of Cholestoff because I have been taking it for about a month and have developed unusual heart palpitations.I will stop taking it and hopefully the will go away.

        • cindy

          same!! very horrible paplitations and chest pains and flutterings

      • SherryR

        I have been taking it for approx 6 weeks. I am having odd heart rhythms or palpitations too…that’s why I am on this site! I wonder if 2 tablets twice a day is too much for me? I am a small person (5’1″ and 100 lbs) It doesn’t make sense that the dosage would be the same for someone my size and also a large male…? Thoughts?
        I am hopeful this will lower my LDL because I refuse to go on Statins!!

    • Randy

      I have had heart palpitations for over 40 years. I take magnesium (American diets very deficient in Mg which you get from green leafy vegetables like kale) for my palpitations. I notice that it helps a lot. I take 400 mgs at night – very soothing to the system. Dr. Carolyn Dean, M.D., N.D.(also a naturopath) wrote a book – The Magnesium Miracle – about magnesium. You may want to look into this and see if it is helpful for you.

      • cindy

        thank you for the info as any statin drug or cholestoff does this to me I am willing to try anything the palpations and chest pains and fluttering are horrible when I take cholestoff I just cant

  • Does cholestoff turn your stool dark?

    Does cholestoff turn your stool dark?

  • Hope this works for me
    Anonymous (Verified Purchase)

    I just start taking CHOLESTOFF… hope it works for me… after taking Crestor for a long time I start having terrible muscles pain. I’ll post again in a couple of month and see if it owrks for me

  • debbie levesque

    i’m on 40mg of zocor, can i take cholest off with that.

  • Product absolutely works!
    Catherine (Verified Purchase)

    I t works. In 6 months went from 220 to 181.

  • Product really works and lost weight
    jerry (Verified Purchase)

    I would like to say this stuff really works!!! I dropped from a 163 to a 130 in 2 weeks, I promise!! I really believe I will be at good levels within 2 months

  • CholestOff
    DIANE (Verified Purchase)

    My moms cholesterol level went down 24 points on this, but while taking this with Red Rice Yeast she got really really ill and had to stop the Red rice yeast. I am taking Cholest off and have lost a few pounds already!

    • Mary

      ive been taking cholest off for appx 6 weeks due to high total cholesterol. Happened to also lose a stubborn 6-7 pounds since starting. I’m sure weight loss is directly related to the pills. Haven’t had follow up blood work yet. Dr. wants to test in 6 months.

  • I have used Cholestoff w/ Red Yeast Rice for several years. My cholestrol level continues to come down. I have avoided taking prescription medication. High cholestorl runs in my family and I have wanted to avoid taking it. I am also a runner [I run every day] and a vegetarian!
    Colleen (Verified Purchase)

    I have used Cholestoff w/ Red Yeast Rice for several years. My cholestrol level continues to come down. I have avoided taking prescription medication. High cholestorl runs in my family and I have wanted to avoid taking it. I am also a runner [I run every day] and a vegetarian!

  • Has anyone else had digestive issues along with Cholestoff?
    Sheri (Verified Purchase)

    I’ve had really good luck with Cholestoff lowering my cholesterol numbers, but I’m having a lot of bloating, gas, and loose stools. Lots of stress in life right now, so I’m not sure what is the culprit, but started taking Cholestoff about the time the stress began. Has anyone else had digestive issues along with Cholestoff?

    • Larry

      I had the same bloating thing at first, but it seems to have gone away. Maybe because I now make sure I take it before a meal (or just after).

    • Linda

      I have been on it for about 4 months. I do suffer from digestive issues, mostly due to taking a lot of supplements. However, since taking Cholestoff Complete, I have had consistently very loose stools. I plan to go off it when I finish the last bottle. Also, I have been under recent stress and my blood pressure has gone up dramatically. Had to change blood pressure medications. I will go for blood work this week to see if the Cholestoff even reduced my cholesterol. I didn’t feel well recently and stopped all supplements including Cholestoff, and the diarrhea stopped.

    • Anonymous

      Have had no side effects and my numbers are way down!

    • Cynthera

      I’ve had the same thing. Lots of gas at night and loose stool in the morning. Just started it about 2 weeks ago. Not terrible — but definitely some digestive issues. I wondered if it was having an effect on the fats being digested in the food?

  • can I take cholestoff instead of zocor?

    Zocor has given me diabetes
    can I take cholestoff instead of zocor?

    • tony

      zocor has given you diabetes???? are you positive???maybe I should stop taking zocor!!!

      • Anonymous

        alot of the prescription statins cause your blood sugars to go way up. Same thing happened to me, was put on meds for diabetes and test every day with my meter. Went of statins and guess what diabetes went away and metformin discontinued!!!!!! It is not an uncommon complication of statin drugs. I am going to try cholestoff instead….

      • Sue

        Yes. Stations do have died effects major one is diabetes. My husband wAS on lepitor and developed diabetes. Plus muscle pain etc.

  • I decided to continue taking it.
    medy (Verified Purchase)

    As a nurse I was very skeptical to take supplements and statin. I came across Cholesteroloff at Costco and read the ingresients. I asked my doctor about it and we both decided to check my cholesterol level as the baseline reading.However, I was still skeptical and waited another month.Then I decided to take Cholesteroloff for 4-6 weeks and had my cholesterol level checked and to my surprise my cholesterol dropped to 193.I decided to continue taking it but will have frequent chemistry testing of my kidneys, liver and cholesterol or lipid profile.Furthermore,hyperlipidimia runs in my family.

    • medy's arch nemesis

      193 from what? Think before posting people. Unless you give numbers to compare to, this new number is absolutely useless information. You must have made such a reckless nurse.

      • RBW.

        Take a chill pill and an antihistamine for your snot nose

        • Monique

          I’m going to try it. I shall let you know the outcome..

        • Steven Montag

          Perfect 👍

  • Cholestoff really worked for me!
    Stephanie (Verified Purchase)

    I have been taking Cholestoff for months..after having horrible side effects from prescription statin meds. which did not work well. Cholestoff really worked for me! My doctor was so pleased with my blood test results and then I told her that I had been taking Cholestoff for the previous 6 months. (she had never heard of it!)

  • I used cholest off for 4 months without side effects
    Steve (Verified Purchase)

    I take losartan and metoprolol er and have used cholest off for 4 months without side effects. I also started a low fat low cholesterol diet at the same time. My blood test showed a drop in total chol. from 235 to 193. If you’re interested in this product you can buy 240 caplets at amazon.com fo about $15 (about a 2 month supply) There are other supplements that are supposed to be much better, but they run about $35-$40 per month. With the cost so low, it’s at least worth a try.

  • Asking for diet chart.

    can you take cholet off & fish oil together

    • Anonymous

      Yes you can my dr recommended me taking the two together

      • Terry

        You should also take K2 and D3 supplements with CholestOff. K2 is critical for cardiovascular health, and statins deplete it. Take CholestOff with a meal to avoid stomach issues.

  • Going to start it.

    With no diet modification my cholesterol has remained as with meds. I’m going to change my diet to try and reduce it further. At least I have no muscle pain w/ Cholestoff. Muscle pain is a major side effect of Simvastatin.

  • gladys

    can i take this my blood presure meds

    • rosie montoya

      Can we take highblood presure medication

  • I would like to see scientific studies on Cholestoff.
    Dennis Jones

    I would like to see scientific studies on Cholestoff. Otherwise, I do not take your commendable comments of Cholestoff seriously.

    • Dustin

      There have been studies and everything in these comments are what is found in these studies. It is suggested to consult a doctor before taking any pill like this because it can cause issues like blood sugar rising and constipation ect. If you have any of the symptoms that this might cause your doctor might advise against it. Now unless you have high blood sugar or close to borderline trying this product could be an issue. I seriously suggest consulting a doctor before taking this.

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