Updated: 04/18/2017 - Site operated by Leptigen

CholestOff Review - Does This Dietary Supplement Work?

  • 60 User Comments
  • Rating: 3.2. From 35 votes.
By Summer Banks Mar 26, 2017

Why are people talking about CholestOff? We decided to take a closer look at the ingredients, side effects, clinical research and customer service quality. Additionally, we read hundreds of user reviews and complaints online. Then, we summarized and condensed to give you the info you need.

CholestOff Readers: Click here to find out why we're giving away samples of our product, Leptigen.

What is CholestOff?

First off, CholestOff ingredients are plant sterols/stanols 900mg, vitamins and minerals. It promotes wellness by lowering cholesterol levels and improving heart health. The recommended serving is two capsules, twice per day. One benefit is that you can take on-the-go.

CholestOff is manufactured by Nature Made, a company that’s been operating for more than 40 years. The supplement is available through trusted retailers and local grocery stores. We like that it contains a natural ingredient and that we located some positive customer comments, but read on…

Lack of Results – “No Weight Loss?”

The first concern was the lack of results from CholestOff ingredients. “This supplement is linked to reducing cholesterol and improving overall wellness,” said our Research Editor. “So if you’re looking to lose weight, this product probably isn’t the best way to reach your goals.”

“I saw minor improvement in my bad cholesterol, but I didn’t lose any weight,” said a user.

“No weight loss at all, extremely disappointed,” said another.

Some users did see manage to lose weight while using CholestOff. “I believe that Cholestoff and healthy eating improved my weight-loss,” commented a dieter.

CholestOff Side Effects – “Concerning?”

Several reviewers online mentioned CholestOff side effects being a cause of concern. “With CholestOff, I’ve been having joint pain and discomfort,” said one customer.

“This stuff has led to constipation for me; I won’t buy again,” said another.

I developed the same side effects that I had while taking the Statins. The side effects consisted of severe and debilitating muscle cramps,” commented a user.

We noticed not every customer experienced the same effect while using CholestOff. “I experienced no side effects (I lost some weight but I’m not sure there’s a direct connection),” said a customer.

“Safe and effective I have been using it for years. No side effects ,” reported a consumer.

We’ve discovered that when a particular part of a dietary supplement is considered troublesome, like causing adverse reactions, the likelihood of long-term success is slim. If CholestOff causes negative side effects for some customers, it could make it difficult for dieters to reach their goals.

The Science – “Researched?”

We’re encouraged by the science behind CholestOff. There are several studies showing the key ingredients help lower cholesterol levels and improving overall health and wellness. Unfortunately, when it comes to weight-loss, there doesn’t seem to be any clinical studies. At DietSpotlight, science-based facts are a critical part of the review process. Without evidence that a product is effective for weight loss, we’re skeptical about it.

The Bottom Line – Does CholestOff Work?

Are you heading out the door for a bottle of CholestOff? Well, we like that it contains some clinically-tested ingredients and is located in a variety of locations, but we’re a bit concerned about this one because the research doesn’t relate to weight-loss. Also, we’re hesitant about it due to lack of results and negative side effects.

If you’re looking to improve overall health and increase weight-loss, we suggest going with a supplement that provides more bang for your buck and scientific evidence that proves it works.

Among the best products we’ve seen in 2016 is one called Leptigen. The clinically-tested formula of four ingredients has been shown to help burn fat and boost metabolism. We’ve read hundreds of user reviews and comments and people are seeing great results without harmful side effects.

Also, the makers of Leptigen  are offering customers a Special Trial Offer, which is a sign of confidence in their product.

Previous CholestOff Review (Updated September 20, 2014):

What You Should Know About CholestOff

Cholestoff, manufactured by Nature Made, is a product that claims to naturally help to lower the cholesterol for those that high levels of it. This product is said to contain ingredients that have been well known to lower the cholesterol naturally in the body and these ingredients reportedly prevent the body from absorbing any further dietary cholesterol.

According the statements on the Cholestoff site, the natural supplement can help to reduce the cholesterol by up to 24% and also reportedly helps to improve the overall health of the heart as well.

List of ingredients in CholestOff

Cholestoff contains quite a range of ingredients and among these are: plant sterols or stanols from pine trees, Tribasic Calcium Phosphate, Croscarmellose Sodium, Hydroxypropyl Methylcellulose, Calcium Carbonate, Silicon Dioxide, Magnesium Stearate, Titanium Dioxide (artificial color), Polyethylene Glycol, Triethyl Citrate, Polysorbate 80 and Sodium Citrate.

Product Features

First of all, when looking at Cholestoff you should be made aware that the bottom of the site clearly states that the product is not meant to cure, treat, diagnose or prevent any disease which makes the viewer wonder if the product matches the hype that has been attached to it. Secondly, it also mentions that it has not in any way been evaluated by the Food and Drug Administration (FDA) which again leads to scepticism about the product.

Cholestoff is not suitable for pregnant women or women who are breastfeeding and also, despite the fact that it is a supplement, the user should consult with a medical professional such as their local doctor or physician before taking the product.

Advantages of CholestOff

  • Cholestoff uses plant derivatives as its active ingredients which are all natural.
  • Cholestoff is very inexpensive. One bottle of Cholestoff retails for about $7.

Disadvantages of CholestOff

  • Cholestoff makes a lot of claims on the official website but has limited information backing them up.
  • For those with high cholesterol, you may want to rely on products a little more well known to avoid serious health issues.
  • Various reviews around the Internet vary greatly between "Doesn't work" and "Wonderful" so we can't get a good feel for the effectiveness of this product.
  • Cholestoff is ineffective as a weight loss supplement.


High cholesterol can lead to life-threatening conditions if left untreated for a long period of time. Cholestoff claims to help lower your cholesterol which could be very beneficial. This product is so inexpensive, we don't see how it could hurt to add it to your daily routine if you are concerned about your cholesterol levels but you may want to use it in addition to something recommended by your physician. We can't really categorize Cholestoff as a "weight loss" product so if you are looking for a way to lose weight, you should probably keep looking.

CholestOff Questions & Answers:

We looked over hundreds of user comments about CholestOff to make this helpful FAQ.

What are the side effects of CholestOff?

CholestOff side effects could include bloating, indigestion, gas, and stomach pain.

What are the ingredients in CholestOff?

CholestOff ingredients are Plant Sterols/Stanols (Pine Tree), Calcium Carbonate, Tribasic Calcium Phosphate, Croscarmellose Sodium, Hydroxypropyl Methylcellulose, Silicon Dioxide, Magnesium Stearate, Color Added, Polyethylene Glycol, Triethyl Citrate, Polysorbate 80, and Sodium Citrate.

Does CholestOff work?

There are no ingredients in CholestOff that work to increase weight-loss or improve metabolism.

You may want to consider giving a product like Leptigen a try, if you’re trying to lose weight. The ingredients are clinically tested and reviews show dieters are losing weight.

How much does CholestOff cost?

For a one-time purchase, you can buy it for about $13.00.

How should I take CholestOff?

You should take two capsules two times a day.

Can I take CholestOff if I have a health condition?

You should ask your physician if you have health problems, are under the age of 18, pregnant, nursing, or are taking prescriptions.

What do users like about CholestOff?

A few users that took CholestOff said they achieved a lower cholesterol.

What do users NOT like about CholestOff?

Users do not like the potential side effects that go along with taking CholestOff.

How do I contact CholestOff customer service?

You can contact CholestOff customer service by calling 1-800-276-2878 or by going to their contact us page on their official website.

What company is behind CholestOff?

Nature Made is the company behind CholestOff.

Does CholestOff contain yeast?

No, CholestOff doesn’t contain yeast, starch, preservatives, synthetic dyes, or gluten.

Do you know of any special deals or discounts on CholestOff?

There are deal and discounts, if you subscribe to get CholestOff once every one to six months; you can save between 5% and 15%.

If you’re looking to lose weight, you may want to look at Leptigen’s Special Trial Offer. Users are going crazy over the deal because it’s only the cost of shipping and handling. Click here to check it out!

CholestOff Side Effects:

Cholestoff is a supplement that you take twice a day to help decrease your cholesterol and improve your heath. Even though side effects don’t happen all the time, we did find user reviews that report a few.


“I have been taking Cholestoff for several weeks, and I developed heart palpitations during this time.”    Roberta


“… I’m having a lot of bloating, gas, and loose stools.”    Sheri


“…[I have] experienced muscle and joint stiffness while using this product…the stiffness is very bothersome.”    Sue


“… it bothered my stomach a bit… Then I started having this really bad ache in my left calf. I did not know what it was. It got much worse and started in my foot. Both my legs below the knees ache.”    Sandra


“But just after taking it for a few days, my wife complained that she felt dizzy and head ache. Then she stopped taking it anymore and got back to normal.”    Bob


“Causes me to have stomach distress.”    Walter


“After three days, I experienced severe joint muscle pain in my left sciatic nerve, terrible pain in my right leg and was unable to stand on it for a few minutes.”    Synthia


“The side effects consisted of severe and debilitating muscle cramps.”    Norman


“I recently purchased this product and it made me sick for three days until i discontinued it.”    Matt


“Omg! Gas, pain, and diarrhea.”    Carol


Interested in trying out the best weight-loss supplement we’ve seen this year? Look no further. Leptigen‘s four ingredient formula is made up of clinically tested ingredients shown to help boost your metabolism.

Click here to check it out.

CholestOff Ingredients and Supplement Facts

Serving Size: 3 softgels
Serving Per Container: 120
Amount per Serving % DV
Calories 15 *
Plant sterols / stanols 900 mg *
Pantethine 300 mg *

Other Ingredients: None

We dug deep into the Cholestoff ingredients to give you the details you need.

Plant Sterols

Plant sterols are naturally occurring substances found in seeds, grains, nuts, legumes, fruits, and vegetables. They are also sometimes added to other foods.

What is it Supposed to Do?

Plant sterols are known for their ability to help lower cholesterol.

Clinical Research

According to a study published in Atherosclerosis, “it has potential value as an adjunct to dietary therapy in patients with mild hypercholesterolemia for whom long-term drug therapy is deemed advisable.”

Clinical research is an important part of the equation when it comes to choosing a diet supplement. You may want to take a look at a product like Leptigen, which is formulated with clinically tested ingredients.


These are naturally occurring substances similar to plant sterols.

What is it Supposed to Do?

They are known for their cholesterol lowering abilities.

Clinical Research

According to a study published in Mayo Clinic Proceedings, “Present evidence is sufficient to promote use of sterols and stanols for lowering LDL cholesterol levels in persons at increased risk for coronary heart disease.”


Calcium is the most abundant mineral in the body. It is found in a variety of food sources including dairy products and leafy green vegetables. It is also added to some foods and is available in supplement form. There are a number of calcium supplements available, such as calcium citrate, and calcium with vitamin D.

What is it Supposed to Do?

Most of it goes to the bones and teeth for structure and support, but the remaining small percentage stays in the blood and muscle tissue.

Clinical Research

According to a study published in Atherosclerosis, “There was no significant difference in the cholesterol levels in the yoghurt and calcium groups.” We found no connection with weight-loss.

Magnesium Stearate

This is a “flow agent” added to many dietary supplements. It doesn’t do anything to help the body in any way.

What is it Supposed to Do?

It is supposed to keep ingredients from sticking together during mixing and compression. It adds no nutritional value to the supplement.

Titanium Dioxide

A chemical most often found in sunscreens. In other products it’s there to maintain color.

What is it Supposed to Do?

It is used as a colorant, and adds no nutritional value to the supplement.

Silicon Dioxide

It is a chemical, also known as silica.

What is it Supposed to Do?

It is an anti-caking agent, designed to keep the ingredients from sticking together during production. It adds no nutritional value to the supplement.

Is There Anything Out There That TRULY Works?

We have our eye on a supplement that fits the bill. Leptigen, which is formulated with ingredients that HAVE been clinically tested, may be a good option. All customers can take advantage of a Special Trial Offer, currently available. Click here to give it a try.

Get Your Sample Today »
Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Leptigen, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 3.2. From 35 votes.
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User Comments (60)


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dotty b


Your Name

Thank you.

Your Name

Just had my annual physical. Dr had wanted to put me on stating to reduce cholesterol levels. I refused because of their side effects. I started taking Cholestoff at the beginning of the year along with a healthier diet and she said my levels are down substantially, she no longer wants me to take stating and told me to keep up whatever I’m doing. NO WHERE have I seen Cholestoff claim to be a weight loss supplement. Weight loss shouldn’t be sought through magic pills but rather through a healthier lifestyle…cholesterol control is different.


My moms cholesterol level went down 24 points on this, but while taking this with Red Rice Yeast she got really really ill and had to stop the Red rice yeast. I am taking Cholest off and have lost a few pounds already!


ive been taking cholest off for appx 6 weeks due to high total cholesterol. Happened to also lose a stubborn 6-7 pounds since starting. I’m sure weight loss is directly related to the pills. Haven’t had follow up blood work yet. Dr. wants to test in 6 months.


I’ve had really good luck with Cholestoff lowering my cholesterol numbers, but I’m having a lot of bloating, gas, and loose stools. Lots of stress in life right now, so I’m not sure what is the culprit, but started taking Cholestoff about the time the stress began. Has anyone else had digestive issues along with Cholestoff?


I have been on it for about 4 months. I do suffer from digestive issues, mostly due to taking a lot of supplements. However, since taking Cholestoff Complete, I have had consistently very loose stools. I plan to go off it when I finish the last bottle. Also, I have been under recent stress and my blood pressure has gone up dramatically. Had to change blood pressure medications. I will go for blood work this week to see if the Cholestoff even reduced my cholesterol. I didn’t feel well recently and stopped all supplements including Cholestoff, and the diarrhea stopped.


I had the same bloating thing at first, but it seems to have gone away. Maybe because I now make sure I take it before a meal (or just after).

Dennis Jones

I would like to see scientific studies on Cholestoff. Otherwise, I do not take your commendable comments of Cholestoff seriously.


There have been studies and everything in these comments are what is found in these studies. It is suggested to consult a doctor before taking any pill like this because it can cause issues like blood sugar rising and constipation ect. If you have any of the symptoms that this might cause your doctor might advise against it. Now unless you have high blood sugar or close to borderline trying this product could be an issue. I seriously suggest consulting a doctor before taking this.

a b

I’ve taken Cholestoff for nearly six months months – also lowered use of mayonnaise, cheese, red meats, etc. Cholesterol went down from 253 to 197. Weight also went down from 171 to 149. No apparent side-effects.


I have been taking cholestoff plus for a year now. I just had blood done, I went from 229 to 236….what the heck!! I also had heart papatations. I stopped taking it and so far no palpatations..


Similar situation for me cholesterol-wise…Cholestoff sucks


I only recently began taking Cholestoff due to first time lab results with high bad cholesterol level. I’m glad it doesn’t cause weight loss as its not a weight loss product. I am a female in my upper 50’s, thin (125 lbs) and always have low blood pressure. Due to past accident, I’ve had neck surgery due to 3 bulging discs so have developed pain and arthritis which is chronic. I have not noticed any side effects (yet)–only started about a month ago–but normally side effects show up pretty quickly if there are any. My only concern is that I read this product can interfere with vitamin absorption, such as Vit. D, E and a couple others. This should be more publicized with the product so that people can adjust when to take any vitamin supplements (in between Cholestoff ingestion times). I won’t know how effective this product is until another 5 months or so when I plan to have another blood test


I just started taking the original not sure which one since there are two others cholestoff. My Total is out of site 435 can’t take statens any more cant take Zetia or Gemfiberozil so doctor didn’t know what else to put me on my daughter takes this so I thought I would try it hope I got the right kind I’ll find out

SueGYour Name

Has anyone experienced muscle and joint stiffness while using this product ? It has worked in lowering my cholesterol , but the stiffness is very bothersome.

Martin Andrews

I’m having the same problem went from walking 31/2 miles to none because my joints and muscle hurt so much stopping taking it will let you know

Lisa M.

SueG, I have been taking the Cholestoff extra strength for a year now, and just recently experienced the same effects you stated. I’ve been fine, and now I had to stop because of the muscle cramping and aching joints. I can’t take Lipitor because the pain and cramping in my lower body was terrible.


Will it work if your body makes cholesterol? I want to lower it naturally. Just bought some to try.

Candace (Editor)

All human bodies produce cholesterol. If you mean an excess of bad cholesterol then you should take this product to your doctor to see if this can help you.


My particle cholesterol level went from 2847 to 2532 in 6 weeks. A little over a year it was 1450. My calculated cholesterol went from over 200 to 145. Those are two types of cholesterol tests. The particle is more accurate. Cholestoff works! The biggest diet change I made was decreasing my ice cream intake.


I took this product for a little over a year. My cholesterol went from 2832 to 1450. This is from a particle lipid test, not calculated. Most people have the calculated test, whereas your number should be below 200. A particle test is more accurate. You can have a normal calculated test, but particle shows the truth. Cholestoff works!

Jose Gonzalez

I take Crestor and Metformin. Is CholestOff Plus safe to use with these medications?

Your Name

It is safe to use with statins buf double check with your doctor first.Tell us your thoughts about Cholestoff.


How soon does Cholestoff starts working?

Your Name

I had a particle lipid test done. My cholesterol went from 2832 to 2547 in 6 weeks. A little over a year it went down to 1450.


It’s not cheap


Yes it’s not but is it worth it for a healthier life? I do believe it is probably better and safer for you.

Edward Bond

U are soooo correct


I have been taking Cholestoff for several weeks, and I developed heart palpitations during this time. Not sure if they’re connected. Has anyone else had this experience? Does Cholestoff contain anything that could be bad for the heart?


I been taking Cholestoff for nearly a month and until i read that you were having palpations i couldnt figure out why my heart was beating differently almost like its racing i will stop taking cholestoff. Did your palpations stop after discontinuing it.


I have been taking it for approx 6 weeks. I am having odd heart rhythms or palpitations too…that’s why I am on this site! I wonder if 2 tablets twice a day is too much for me? I am a small person (5’1″ and 100 lbs) It doesn’t make sense that the dosage would be the same for someone my size and also a large male…? Thoughts?
I am hopeful this will lower my LDL because I refuse to go on Statins!!


I went online today to look up the side effects of Cholestoff because I have been taking it for about a month and have developed unusual heart palpitations.I will stop taking it and hopefully the will go away.


Does cholestoff turn your stool dark?


I just start taking CHOLESTOFF… hope it works for me… after taking Crestor for a long time I start having terrible muscles pain. I’ll post again in a couple of month and see if it owrks for me


I t works. In 6 months went from 220 to 181.