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Plenity Review - 13 Things You Need to Know

There are only a handful of medications approved for weight-loss by the Food and Drug Administration. In late 2019, Plenity was added onto the short-list of approved weight-loss prescriptions, so our team decided to look into the product.

Our research team went over the product’s release date, potential prices, ingredients, potential side effects, and more. After, they gathered the important facts to give you the bottom line on this new prescription medication.

Plenity can be purchased through their Official Site.

Plenity Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Plenity?

What is Plenity

Plenity is a weight-loss prescription medication that the FDA approves. It is made from natural building blocks cellulose and citric acid.

When taken before meals, the medication is designed to target the gastrointestinal tract to make you feel fuller. It is considered non-systemic, which means the product only targets the gastrointestinal system instead of the whole body.

Plenity is now available by prescription. The official website offers to help you connect with a healthcare provider for evaluation and treatment if deemed appropriate. Plenity is exclusively available through Roman, a telehealth company. It is not available through standard or traditional pharmacies.

Its benefits have been proven in clinical studies, and it seems easy to use, and this is what a few of them have to say:

  • EndotextResearch into Plenity found that the product could help cause between 5-8% weight loss in certain individuals.
  • Therapeutic Advances in Gastrointestinal EndoscopyThis study found that “The pilot study on 128 non-diabetic overweight patients showed that Plenity 2.25 g twice daily was associated with significant weight loss compared to the placebo group.”
  • Gastroenerology & HepatologyPlenity works by making individuals feel fuller and cause a reduction in eating.

Plenity Competitors

Amsa Fast

Who Makes Plenity?

Gelesis is the manufacturer of Plenity. This biotechnology company seems to be fairly new and focused on solutions for problems in the gastrointestinal tract.

The company has only released one product so far. However, they plan to release more medications in the future.

Plenity Customer Service

Ro Care Team by email at plenitycare@ro.co or call or text (Mon – Fri: 9:30 am – 9 pm EST) at 424-347-6299.

You can email GoGoMeds at hello@gogomeds.com or call 1-888-795-5826.

On the Gelesis website, individuals can submit a contact form, write to 500 Boylston St, Ste 1600, Boston, MA 02116 or call 617-456-4718.

Plenity and the Better Business Bureau (BBB)

While Plenity and Gelesis do not have a BBB page, you can purchase Plenity through Roman Health Ventures. They have been accredited since 2018 and have an A+ rating. There have only been 10 closed complaints in the last three years, and just four of those in the past 12 months.


Plenity Claims

Plenity claims to help users feel more full naturally, meaning you will eat less and lose more weight. Combined with diet and exercise, the medication claims to be a clear way toward weight management from natural ingredients.

On the official Gelesis website, studies for the medication found clinically meaningful weight loss from the product. The manufacturers claim these studies prove the effectiveness of the medication.


Plenity Ingredients

Plenity, an oral weight loss gel capsule, is only made up of cellulose and citric acid. These two ingredients create a 3D hydrogel matrix. Once the product enters the stomach, the matrix breaks apart into individual cells.

These individual cells are designed to hold 100 times their weight. One study published in Obesity (Silver Spring) found that hydrogels be associated with weight loss


Does Plenity Work?

Does Plenity Work

Plenity says all its ingredients are natural with no synthetic properties. However, the product is non-systemic, meaning the ingredients are designed only to target a specific area. In this case, Plenity only targets the gastrointestinal system.

The two natural ingredients – cellulose and citric acid – create a three-dimensional property to cause you to feel fuller and quicker at mealtime. These ingredients take up space in the stomach and small intestine, giving you the feeling of fullness throughout the day.

The formula can hydrate 100 times their original weight, and once the particles enter the colon, the water reabsorbs back into the body. They are then moved out of the body with bowel movements, according to research published in The Annals of Pharmacotherapy.

Additionally, one animal study published in the JoD noted that cellulose was associated with reduced body weight gain.

Weight Loss

Plenity and Weight Loss

Plenity is one of the very few medications approved by the FDA for weight loss, according to Endotext. As such, the product has needed to undergo some studies to prove its effectiveness, including ones published in The Medical Letter on Drugs and Therapeutics and the ADA.

According to the statistics shared on the official Gelesis website, 59% of the study participants had a clinically significant response to the prescription. These individuals lost an average of 10% of their body weight, and 26% of the group were classified as “super-responders” that lost at least 14% of their body weight.

Another study in Obesity: A Research Journal found that Gelesis100 – the absorbent hydrogel in the formula, was safe and tolerable for human health.

Side Effects

Plenity Side Effects

The Plenity pill notes some of the adverse reactions that were in the original study. These side effects include:

  • Abdominal distension
  • Abdominal Pain
  • Constipation
  • Diarrhea
  • Flatulence
  • Infrequent Bowel Movements
  • Nausea

However, everyone will react differently. It is important to discuss possible options and side effects with your doctor.


Who is Eligible For a Plenity Prescription?

Who is Eligible for a Plenity Prescription

Plenity has plenty of safety information available on their website. To get a prescription, individuals must consult with one or their doctors online through the Plenity login.

You should avoid the product if you are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide. You should also stay away from the medication if you are pregnant.

The product is only designed to be used by individuals with a BMI of 25 – 40. To avoid problems with Plenity absorbing other medications, make sure to follow the food intake recommendations.

Currently, Plenity is not available for residents of Florida and Virginia.


How to Use Plenity

The official website says users should take 3 Plenity capsules 20 minutes before lunch and dinner. Additionally, you should drink at least 16 ounces of water when consuming, so it actually works.

Plenity recommends using the 20 minutes before your meal to plan your food and practice mindfulness.

Costs and Where To Buy

Costs and Where to Buy

The cost for the Plenity diet pill depends on the type of insurance coverage you have, your out-of-pocket, and your co-pay. There may also be a Plenity coupon and discounts by the manufacturer to help with the cost.

Plenity is now available through telehealth company Roman. Gelesis, the makers of Plenity, decided to go this route to reduce the cost of marketing and sales so the cost to the consumer could be kept low. As such, treatment with Plenity costs just $98 a month, or $1.75 per meal. However, in order to purchase the product, individuals must complete an online telehealth program.

Plenity Refund Policy

Since Plenity is considered a prescription medication, the company does not accept any kind of returns, which means customers cannot usually get a refund.

Pros and Cons

Pros and Cons


  • Scientific proof of weight loss
  • Easy to use
  • Plenity before and after images may show some beneficial results
  • Available via telehealth
  • Low-cost prescription, compared to other weight-loss options


  • Not available through traditional pharmacies
Reddit Reviews

Plenity Reddit Reviews

With over 2.8 million subreddits, it’s no wonder Reddit is a hub for information about supplements, pre-workouts, and meal replacements. Almost 25% of all 25-29-year-olds use Reddit. We researched Plenity Reddit reviews to see what all the buzz is about.

We found Plenity Reddit reviews tended to vary widely, as expected. Reviews on Reddit suggest that some users loved it while others weren’t as thrilled. In this case, users have brought up that they actually gained weight when they started using Plenity. That’s not exactly the feedback a prescription weight-loss pill wants to receive.

Bottom Line

The Bottom Line on Plenity Results

We don’t say it often, but we were surprised by Plenity. The medication is not only clinically proven, but the company behind it all decided to take a unique route to the customer by partnering with the telehealth giant Roman. We are hopeful for its success based upon multiple clinical studies. We also like the simplicity of this program.

Overall, Plenity can be a great option for overweight and obese adults. If you are looking to pair this medication with a comprehensive program that’s also backed by clinical studies, make sure it can be personalized to your needs as well.

We want you to be successful in your weight-loss journey, so we review hundreds of products and services every year. This year, one of the programs that stood out head and shoulders above the competition was Noom.

The company has worked to address weight loss as a total body experience where the mind gets as much attention as the body. Years of research went into creating a program of small, subtle changes that work to teach users how to adopt new, healthier habits. These new habits naturally lead to weight loss, so the effects are lasting. 

Because we want to see you lose more weight than ever before, check out Noom today and get a free trial offer, for a limited time.

Learn More About Noom
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When will Plenity be available?

Plenity will be available for patients via prescription in the latter half of 2020. As of October 2020, the program is open to select individuals who qualify through Roman.

Where to buy Plenity weight loss?

Plenity weight loss device is available exclusively through the telehealth company Roman.

How much does Plenity cost?

Plenity costs $98 a month. It is not available through pharmacies. We found no indication that it is covered by medical insurance.

How to get Plenity?

Go to GetRoman and start your telehealth visit to get started. If your BMI is between 25 and 40 and the healthcare provider you meet with feels the device is a good fit, a prescription will be sent via mail directly to your home.

Is Plenity a prescription?

Yes, Plenity is an FDA-cleared prescription.

Where can I buy Plenity?

Plenity can be purchased using their Official Site.

Is Plenity over the counter?

No, Plenity is available by prescription only to men and women with a BMI between 25 and 40.

Is Plenity available in Canada?

Those clinical testing on Plenity was completed in Canada, we didn’t find an approval for the device in Canada as of July 2020.

When will Plenity be on the market?

Plenity plans to stay a prescription medication. Although the product is available for purchase after an online telehealth appointment, the company plans for the medication to be able to be prescribed everywhere by 2021.

How long does it take Plenity to kick in?

According to Plenity, individuals should feel the effects of the product within a couple of weeks.

How long does it take for Plenity to be digested?

Although there is little information concerning how long it takes for Plenity to be digested, the supplement suggests it should start working effectively in about four weeks.

Does Plenity work with keto diet?

Although individuals may use the keto diet while using Plenity, it is best to consult with a medical professional first.

Where can I buy Plenity?

Plenity is a medication that is only available through prescription.

Why is Plenity not for severely obese people with BMI 40?

Plenity does not disclose why their product is only available for individuals who are between 25-40. However, some believe it is because those who have a BMI of 40 or higher may not experience the same benefits and would need to see a medical professional to lose weight healthily.

How and when to take Plenity if you fast after your lunch and do not eat dinner?

If you are following a fast, it may be good to get advice from the prescribing doctor as to when to take the supplement.

When taking Plenity and constipation occurs, is it safe to use a woman's laxative?

It may be best to consult with a medical professional to see if it is safe to consume a laxative while taking Plenity.

How much weight can you lose on Plenity?

Plenity is a new weight loss aid that has been clinically proven to help people lose up to 10% of their body weight. This can be achieved through a combination of lifestyle modifications and Plenity, which works by reducing ghrelin (the hunger hormone) levels in the stomach. As with any diet or weight loss program, it is important to consult a qualified healthcare provider before starting your journey with Plenity. Consistent monitoring and adjusting your plan is necessary throughout the process as well.

25 Plenity Reviews

  • Lauren

    I lost over 30 pounds in a few months. No side effects. Took a few weeks to start feeling “full” and I realized it’s more a feeling of satisfaction. Really helps with between meal snacking and also keeping bowel movements more regular.

  • Happy
    Connie Wagner (Verified Purchase)

    I use plenity along with a weight watchers style diet. Have lost 19 pounds in four months.

    • Summer Banks FNS, SPT

      FANTASTIC CONNIE!!! Great job!

  • Insurance?

    Is Plentiy covered by Medicare?

    • Summer Banks FNS, SPT

      Hi Lynne. What we found was Medicare typically doesn’t cover weight-loss medications, but may cover various weight-loss programs. Hope this helps!

  • Waste of money
    Kim L (Verified Purchase)

    I have been on Plenity for a month and have not lost any weight. First, in order for the capsules to work you must also decrease your calorie intake by 300 cal per day. If one does that they could lose 1 to 2 pounds without spending an outrageous amount of money. I was stupid and ordered the 3 month supply @ 248.00 seeing I wanted to lose 17 to 20 pounds which would take 3 months to achieve. I will say I felt fuller during mealtime, however, it doesn’t last long enough throughout the day. I also play Pickleball 5 days a week for at least 2 hours a day.

  • deborah (Verified Purchase)

    doesn’t work. my feet swelled up. don’t buy

  • Doesn't work
    Tad (Verified Purchase)

    As others have said, doesn’t work at all. Wasted $$. I tried it for a month, saw no results

  • Ineffective
    Tilly (Verified Purchase)

    I will state what others have said – it doesn’t work. Don’t spend your hard-earned money on a useless product.

  • Wendy Bloom (Verified Purchase)

    It doesn’t work at all. It is suppose to make you feel fuller . What a waste of money

  • Michell E.

    Where can I find a coupon for Plenity ?
    I dropped of my prescription at the pharmacy and it’s $138. I haven’t been able to find coupon online

    • Summer Banks FNS, SPT

      You may be able to get a cheaper price through GetRoman.com – the official website for Plenity. Their cheapest price is $83/month when you order a 3-month supply or $98/month as a 1-month supply. Hope this helps! Summer

  • Useless medical device.
    DJ0915 (Verified Purchase)

    Yeah, spent quite a bit of money only to get no results. I feel no difference in fullness whatsoever. A useless and expensive medical device.

  • It Works!
    Sarah (Verified Purchase)

    Plenity has been working for me. I take it as directed and have noticed that I don’t finish my meals because I feel full. I have had no side effects and am down 7 pounds in 1 week. The weight loss is from eating 3 meals a day with a protein serving at every meal, exercising 5 days a week, including vegetables at meals, and of course, eating less but feeling full with Plenity.

  • Over priced non effective product. PLENITY
    Earl Williams (Verified Purchase)

    I tried plenity and it did nothing for me. I’m not a happy customer. Very expensive product that has no results. Don’t waste your money.

  • Check your BMI first I guess :(

    Im sad its so restricted towards people with a BMI of 25-40 only. Mine is 41.5 and I was denied. I was so hopeful, surgery isn’t the best option for some people and this seemed like it could be the next best thing. Hoping my husband has better luck.

  • I doesn't work, they want you to take 6 months of it before it works.
    G (Verified Purchase)

    Waste of money

    • Earl Williams

      It doesn’t work I tried it it did nothing for me

  • Wanted it to work
    Lois G (Verified Purchase)

    I just started using it 2 days ago and I have not noticed any feeling of fullness at all. I’ll try it for a week, I am disappointed .

    • Anonymous


  • Want it from my pharmacy
    Karen L. Hilliard

    I just want to know why we can only get it online, if it’s FDA approved why can’t my doctor order it from the pharmacy for me?

    • Montana (Editor)

      Hello Karen. According to their official website, Plenity says individuals do not need to see an in-person doctor to gain a prescription for the weight-loss supplement. Individuals can complete a consultation online to get the medication. However, it seems like the only way to purchase the product is through their website, which Plenity claims is because their product is in short supply.

  • Refuse services because of my Race!!
    Earnest Pearson

    I would love to try the product. They stated it was for people with a BMI over 40 and mine is. The Dr that denied the product stated that my BMI has to be over 40, and I was denied. I had my BMI calculated on their site. I don’t understand why I was denied the product. I guess after the Dr saw my photo he decided that he didn’t won’t to serve my race. That is the only reason I can come up with why he denied helping me to acquire a better quality of life. When he stated that my BMI was not 40. They even state on the site that it was for people that had between 25>40 BMI.

    • Summer Banks FNS, SPT

      Hi Earnest. I’m sorry you’ve had this experience. I’m sure there was a miscommunication somewhere, but Plenity is not approved for men or women with a BMI higher than 40. So, healthcare providers are only prescribing it for patients with a BMI under 40. I hope this helps. Have a great day!

    • Reve Coudes

      You can count it a blessing and 100.00 in your pocket it doesn’t work it’s crap

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