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Plenity Review - 13 Things You Need to Know

There are only a handful of medications approved for weight-loss by the Food and Drug Administration. In late 2019, Plenity was added onto the short-list of approved weight-loss prescriptions, so our team decided to look into the product.

Our research team went over the product’s release date, potential prices, ingredients, potential side effects, and more. After, they gathered the important facts to give you the bottom line on this new prescription medication.

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What is Plenity?

Plenity is a weight-loss prescription medication that is approved by the FDA. It is made from natural building blocks cellulose and citric acid.

When taken before meals, the medication is designed to target the gastrointestinal tract to make you feel fuller. Its benefits have been proven in clinical studies, and it seems easy to use. It is considered non-systemic, which means the product only targets the gastrointestinal system instead of the whole body.

The medication is classified as a weight-loss device or pill and is scheduled to hit the marketplace in 2020.

Update October 2020: Plenity is now available by prescription. The official website offers to help you connect with a healthcare provider for evaluation and treatment if deemed appropriate. Plenity is exclusively available through Roman, a telehealth company. It is not available through standard or traditional pharmacies.

Who Makes Plenity?

Gelesis is the manufacturer of Plenity. This biotechnology company seems to be fairly new and focused on solutions for problems in the gastrointestinal tract.

The company has only released one product so far. However, they plan to release more medications in the future.

Plenity Customer Service

On the Plenity website, they claim you can call 1-844-PLENITY – or 1-844-753-6489 – to learn how to use the medicine properly or for more information. On the Gelesis website, individuals can submit a contact form.

Plenity Customer Testimonials

Plenity Claims

Plenity claims to help users feel more full naturally, meaning you will eat less and lose more weight. Combined with diet and exercise, the medication claims to be a clear way toward weight management from natural ingredients.

On the official Gelesis website, studies for the medication found clinically meaningful weight-loss from the product. The manufacturers claim these studies prove the effectiveness of the medication.


Plenity Ingredients

Plenity, an oral weight loss gel capsule, is only made up of cellulose and citric acid. These two ingredients create a 3D hydrogel matrix. Once the product enters the stomach, the matrix breaks apart into individual cells.

These individual cells are designed to hold 100 times their weight.

Does Plenity Work?

Plenity says all its ingredients are natural with no synthetic properties. However, the product is non-systemic, meaning the ingredients are designed only to target a specific area. In this case, Plenity only targets the gastrointestinal system.

The two natural ingredients – cellulose and citric acid – create a three-dimensional property to cause you to feel fuller and quicker at mealtime. These ingredients take up space in the stomach and small intestine, giving you the feeling of fullness throughout the day.

The formula can hydrate 100 times their original weight, and once the particles enter the colon, the water reabsorbs back into the body. They are then moved out of the body with bowel movements.

Weight Loss

Plenity and Weight Loss

Plenity is one of the very few medications approved by the FDA for weight loss. As such, the product has needed to undergo some studies to prove its effectiveness.

According to the statistics shared on the official Gelesis website, 59% of the study participants had a clinically significant response to the prescription. These individuals lost an average of 10% of their body weight, and 26% of the group were classified as “super-responders” that lost at least 14% of their body weight.

Another study in Obesity: A Research Journal found that Gelesis100 – the absorbent hydrogel in the formula, was safe and tolerable for human health.

Side Effects

Plenity Side Effects

On the official website, Plenity notes some of the adverse reactions that were noted in the original study. These include:

  • Abdominal distention
  • Abdominal Pain
  • Constipation
  • Diarrhea
  • Flatulence
  • Infrequent Bowel Movements
  • Nausea

However, everyone will react differently. It is important to discuss possible options and side effects with your doctor.

Who is Eligible For a Plenity Prescription?

Plenity has plenty of safety information available on their website.

You should stay away from the product if you are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide. You should also stay away from the medication if you are pregnant.

The product is only designed to be used by individuals with a BMI of 25 – 40. To avoid problems with Plenity absorbing other medications, make sure to follow the food intake recommendations.

As of October 2020, Plenity is not available for residents of Florida and Virginia.


How to Use Plenity

According to the official website, users should take 3 Plenity capsules 20 minutes before lunch and dinner. Additionally, you should drink at least 16 ounces of water when consuming, so it actually works.

Plenity recommends using the 20 minutes before your meal to plan your food and practice mindfulness.

Costs and Where to Buy

Pharmacies anticipate this drug to be expensive. Pharmacies are in the process of determining how much this new drug will cost the consumer.

Cost also depends on the type of insurance coverage you have, your out-of-pocket, and your co-pay. There may also be coupons and discounts by the manufacturer to help with the cost.

Even though this pill is not available until fall 2020, you can use this time to talk with your doctor about trying this weight loss device when it becomes available.

When can I get Plenity? Plenity will be available in late 2020.

Update October 2020: Plenity is now available through telehealth company Roman. Gelesis, the makers of Plenity, decided to go this route to reduce the cost of marketing and sales so the cost to the consumer could be kept low. As such, treatment with Plenity costs just $98 a month.

Pros and Cons

Pros and Cons


  • Scientific proof of weight loss
  • Easy to use
  • Focus on mindfulness
  • Available via telehealth
  • Low-cost prescription, compared to other weight-loss options


  • Not available through traditional pharmacies

What Users Are Saying

“It wasn’t restrictive. I could still eat the foods that my family was eating, and still make progress towards my weight.”

“I find that Plenity has been extremely helpful. I’m slowly losing weight (about 1lb a week). I’m wondering a bit about the logistics of using Plenity once Covid-19 vaccine is out and I go back to an office. So far I’ve only used Plenity with family meals at home. It might get more complicated with a headier schedule.”

Plenity Ingredients
Bottom Line

The Bottom Line on Plenity Results

We don’t say it often, but we were surprised by Plenity. The medication is not only clinically proven, but the company behind it all decided to take a unique route to the customer by partnering with the telehealth giant Roman. We are hopeful for its success based upon multiple clinical studies. We also like the simplicity of this program.

Overall, Plenity can be a great option for overweight and obese adults. If you are looking to pair this medication with a comprehensive program that’s also backed by clinical studies, make sure it can be personalized to your needs as well.

Among the best in weight-loss programs available today is Noom. The creators used psychology as the cornerstone of the program, so users are taught how to lose weight, and how to deal with any bumps in the weight-loss road that may happen along the way. All programs are personalized and come with a live, human coach – something you don’t see very often.

You can access a special free trial offer of Noom for a limited time. Give it a try while you can!

Learn More About Noom »
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When will Plenity be available?

Plenity will be available for patients via prescription in the latter half of 2020. As of October 2020, the program is open to select individuals who qualify through Roman.

Where to buy Plenity weight loss?

Plenity weight loss device is available exclusively through the telehealth company Roman.

How much does Plenity cost?

Plenity costs $98 a month. It is not available through pharmacies. We found no indication that it is covered by medical insurance.

How to get Plenity.

Go to GetRoman and start your telehealth visit to get started. If your BMI is between 25 and 40 and the healthcare provider you meet with feels the device is a good fit, a prescription will be sent via mail directly to your home.

Is Plenity a prescription?

Yes, Plenity is an FDA-cleared prescription.

Is Plenity over the counter?

No, Plenity is available by prescription only to men and women with a BMI between 25 and 40.

Is Plenity available in Canada?

Those clinical testing on Plenity was completed in Canada, we didn’t find an approval for the device in Canada as of July 2020.

Plenity Reviews