Diet products either work or they don’t. Period. Let’s find out which one Stacker 2 is. We looked at the ingredients, side effects, customer service and clinical research. Furthermore, we examined hundreds of user reviews and comments. Then, we summarized and condensed to give you the bottom line.
What is Stacker 2?
First off, Stacker 2 is a fat burner using the principles of the infamous ECA Stack.  The ingredients are yerba mate, green tea, guggulsterone, cassia mimosoides, white willow bark  and caffeine 200mg. You’ll take one to three per day after meals. The blister pack makes it easy to take with you on-the-go. Supposedly, this formula promotes weight-loss by boosting energy levels and metabolism. 
Stacker 2 was brought to the market more than 20 years ago by NVE Pharmaceuticals. It’s available in at local stores and through the official website. We like it contains a few natural ingredients and it appears to be affordable, but read on…
Stacker 2 Side Effects – “Look Out?”
The first concern was the intensity of Stacker 2 side effects. “This one contains multiple fat burners,” said our Research Editor. “While they’re supposed to boost metabolism, there’s a chance you could experience adverse reactions.” 
“I noticed it also made me jittery and sometimes gave me a headache,” said one user.
“Even after doing intensive workouts I still had too much energy. I had to stop taking them, because occasionally I had caffeine crashes.  They are not fun at all,” offered another.
Side effects are rare, so we found some users that didn’t experience adverse reactions.
“No headache, jitters or anxiety like other caffeine pills,” commented a dieter. 
Results – “No Weight-Loss!”
Based on some Stacker 2 reviews, there’s were customers that didn’t notice results. “I did not experience any weight loss on this product. I did have more energy but I was looking for a fat burner,” said one customer online.
“The pill does give a great amount of energy, but the claim of it being a fat burner is bogus,” said a user.
Upon reading further reviews, some customers noticed results. “I tried them again and they helped me lose weight ,” explained a customer.
“After the first one, I felt warm and could tell my metabolism was increasing,” stated another.
Our research has shown if there is some particular part of a diet supplement that’s troublesome, like not producing results, the likelihood of long-term success is slim. If Stacker 2 doesn’t help you lose weight or burn fat, is it really worth it?
The Science – “Legitimate?”
Some of the Stacker 2 ingredients have been clinically verified to work. The white willow bark extract , green tea extract and kola nut  are common ones that have been shown to be mildly effective. However, the any results aren’t connected to this formula. We at DietSpotlight find clinical research to be important to the review process. When there’s no solid-science used to support the claims, we have concerns.Also: read our Dietspotlight Burn Weight-Loss Kit review »
The Bottom Line – Does Stacker 2 Work?
Will Stacker 2 help you lose weight? Well, we like that it contains few natural ingredients and that we found some positive customer comments, but the lack of research showing it works is concerning. Also, reports of negative side effects and no real results leaves us a bit skeptical about giving it the thumbs up.
If you are still in the market for an effective fat burner, we suggest going with one that’s clinically proven to work, without any mentions of harmful side effects.
Among the best products we’ve seen this year is our product called Dietspotlight Burn. The formula contains four ingredients, clinically-tested, with results often located in The American Journal of Clinical Nutrition and the Journal of Medicine.
We’re so confident in our supplement, that we’re offering a Special Trial Offer, which is a good sign.
Previous Stacker 2 Review (Updated March 19, 2014):
What You Should Know about Stacker 2
Stacker 2 derives its name from the term "stack" or "ECA stack". ECA is an acronym for ephedrine, caffeine and aspirin. When "stacked" or combined correctly it is said to be a fat burner and energy booster. Originally, this product contained ephedrine. The ephedrine has been substituted with a combination of ingredients, called a Proprietary Formula, that supposed to work similar to ephedrine. The official website of NVE Pharmaceuticals, the maker of the product, sells only the ephedrine free version. Be aware that Stacker 2 with the ephedrine formula is still being sold on online stores all over the web.
The official NVE Pharmaceuticals website is attractive if you like flash and sexy videos. The company manufactures and markets a variety of weight loss products and energy drinks. To obtain product information much beyond an ingredients list one has to go elsewhere. The product is inexpensive, less than $20 for a hundred tabs, and available at discounts and in a variety of quantities. If it's a caffeine and energy you seek, you may want to take a look at Hydroxycut, known for it's fat burning ingredients, it's claimed to boost metabolism, endurance, energy levels, and best of all, weight loss.
List of Stacker 2 Ingredients
Kola Nut - The usual source of caffeine in stack formulas.
Yerba Mate - Rumored to help in weight loss, no quality evidence.
Cassia Mimosoides - As a lipase inhibitor it theoretically prevents the body from absorbing and storing fat.
White Willow Bark - The usual source of aspirin in stack formulas.
Caffeine Anhydrous - Mild thermogenic benefit and energy booster.
Green Tea - Proven fat burning and thermogenic benefits in sufficient quantities.
Guggulsterones - Stimulates thyroid and thereby may increase metabolism.
Gymnema - Historically used to treat diabetes. May inhibit taste for sweets.
Stacker 2 claims to be "The World's Strongest Fat Burner". If fat burner is what you seek, GNC Burn 60 is exclusively used for weight loss and can be taken on the go. The formula, called a "Proprietary Blend", is designed to increase your metabolism and therefore your body heat. Be it a proprietary blend or not, many of these ingredients are common in fat burners like Instant Knockout. This stimulates your brain and raises your heart rate. White willow bark is essentially aspirin and the caffeine completes the stack. In addition to weight loss, benefits claimed are a decrease in appetite and an increase in energy.
Advantages of Stacker 2
- Ephedrine free.
- Contains ingredients proven to be helpful in weight loss.
Disadvantages of Stacker 2
- Claims to be free of side effects while containing ingredients commonly known for its side effects, such as caffeine.
- Does not break down the quantities for individual ingredients making it difficult to judge whether sufficient amounts are present to be effective.
- Without ephedrine, there is no evidence that the product will work like a traditional "stack" or "ECA stack" product.
- The importance of diet and exercised is not highlighted.
- No before and after photos or testimonials.
- No guarantee.
Stacker 2 has a few quality positive weight loss ingredients combined with ingredients that are not likely to do anything at all. It is assumed that the Proprietary Blend is greater than the sum of its parts. There is no evidence whatsoever to support that claim. When fad ingredients are involved, like in Batch 5, dieters often report ineffectiveness. It's impossible to measure the potency of the product or determine if there is enough of the ingredients to be effective. If you have had success with traditional "stack" products in the past, you will be disappointed with Stacker 2.
Stacker 2 carries one of those names that's been around for more than a decade. Stacker was once a popular ephedra supplement, but has since expanded the line and eliminated ephedra. You can choose from energy shots, Swarm, Yellow Hornet, Black Jax, and more.
Stacker 2 Ingredients and Supplement Facts
Serving Per Container: 100
|Amount per Serving||% DV|
|- Yerba Mate||*||*|
|- Green Tea Leaves||*||*|
|- Cassia Mimosoides Extract||*||*|
|- White Willow Bark||*||*|
Other Ingredients: Gelatin, stearic acid, magnesium stearate, titanium dioxide, dibasic calcium phosphate, microcrystalline cellulose
We really researched Stacker 2 ingredients to help you fully understand the specifics.
Yerba Mate (leaves)
Sometimes called green mate or hervea, yerba mate is a plant that’s often used to make beverages. It’s quite popular in certain parts of South America. It’s also used in various energy drinks sold in the US. It provides some caffeine, as well as vitamins and antioxidants.
What is it Supposed to Do?
Well, yerba mate is found in a number of weight-loss products. It’s typically claimed to boost energy levels, stimulate metabolism, enhance focus and elevate mood. These benefits are all linked to the caffeine in this herb.
According to the National Institutes of Health, yerba mate has shown some promise in mice. One study revealed, “Yerba Mate has the ability to decrease the differentiation of pre-adipocytes and to reduce the accumulation of lipids in adipocytes, both of which contribute to a lower growth rate of adipose tissue, lower body weight gain, and obesity.” Therefore, “Yerba Mate can potentially be used to treat obesity and diabetes.”
Green Tea (leaves)
Herbal teas are commonly consumed around the world. This is especially true in Asia. Green tea is a variety that grows in regions such as China and Japan. It differs from black tea because it’s unfermented.
What is it Supposed to Do?
First off, green tea contains both caffeine and EGCG (epigallocatechin gallate). Therefore it provides a stimulant and polyphenol. Together these components can help boost thermogenesis.
Some clinical studies have shown the benefits of green tea on weight-loss. One study from the University of Maryland Medical Center says, “Clinical studies suggest that green tea extract may boost metabolism and help burn fat.” In fact, one study revealed, “The combination of green tea and caffeine improved weight-loss and maintenance in people who were overweight and moderately obese.”
Guggulsterone (whole plant)
Also called guggul or devadhupa, guggulsterone is actually made from tree sap. Specifically, it comes from the Commiphora mukul tree, which grows in India. Sometimes this ingredient is used to treat acne blemishes.
What is it Supposed to Do?
Guggulsterone is often claimed to stimulate the thyroid gland. It’s found in many weight-loss supplements. By causing the thyroid to produce more hormones, this can potentially increase the metabolism of fatty tissue.
Unfortunately studies have shown that guggulsterone does not have much of an impact on weight-loss. For instance, WebMD states, “Research suggests that guggul does not affect body weight in overweight or obese people.” However, this plant extract has been shown to help treat acne breakouts.
One that’s caught our attention is one called Dietspotlight Burn. It contains clinically-tested ingredients and have been shown to work. Want to learn more about it; click above.
Stacker 2 Side Effects:
Nowadays, there are a lot of weight-loss supplements around every turn. With that said, it’s important to realize that taking a natural solution doesn’t necessarily mean it can’t cause a negative side effect. With every mixture, there’s a possibility for an adverse reaction, although Stacker2 side effects are fairly uncommon, it doesn’t mean they don’t happen to some users.
A headache is described as a pain in any area of the head or neck. They can be categorized as cluster, tension, and migraines, which are all primary headaches.
What causes a headache?
Primary headaches are caused by over activity in pain-sensitive areas of the head. External pressure and temperature can cause a headache, as well as any direct physical stimuli. Stress, anxiety, and caffeine intake can stimulate nerves in the head as well.
Nausea is an uncomfortable sensation of queasiness or sickness in the stomach, typically preceding vomiting. You may experience a bitter or sour taste in the mouth and throat. These usually accompany nausea.
What causes nausea?
Nausea isn’t a condition in itself, rather a symptom of another issue. There are several factors, including food poisoning or food allergies, which could contribute to this symptom. Parasites or bacteria in uncooked food could lead to an illness which would trigger a nauseous feeling. 
Fatigue is the feeling of being worn out or unrelenting exhaustion. This condition doesn’t seem to be remedied by sleep or rest, often times having a direct impact on daily routines due to lack of concentration and weariness. 
What causes fatigue?
Fatigue could be caused by lack of sleep, jet lag, stress, or diet. More serious conditions could be sleep apnea (frequent stopping and starting of breathing), concussion, or a major depression disorder.
Leg cramps (charley horse) are the involuntary contraction of one or more muscles in the leg. This symptom is fairly common, but could have negative effects on sleep and daily routine.
What causes leg cramps?
Holding a certain position for a prolonged amount of time could cause this effect, as well as dehydration. The narrowing of arteries to the leg could cut blood flow and increase chances of muscle cramps during strenuous activities such as exercise or sports.
Stacker2 side effects are few and far between, but there have been some reports of leg cramps, fatigue, nausea, and some others. In order to save yourself the potential negative reaction, it’s always a good idea to seek the advice of a doctor before taking any supplement, especially if you are under the age of 18, are taking prescription medications, have a pre-existing medical condition, or are pregnant or nursing.
Stacker 2 is a supplement that contains ingredients such as green tea, caffeine, and white willow bark to help boost metabolism and boost weight-loss. We know that they are uncommon, but we went out and found comments from users who experienced side effects.
“The third day I was waking up with mild headaches.” Bailey
“Gave me a headache and sometimes nausea.” Gregory
“I noticed it also made me jittery and sometimes gave me a headache.” Thurston
“When I bought this product I was expecting to get a boost of energy instead I got headaches.” Fredrick
“Makes me jittery, and actually got sick to my stomach.” Dave
“I started getting weird pains in what seemed like my liver.” Bryan
“I just started taking this product last week and now I’m having problems with cramps in my legs, my whole body is jittering, and I can’t sleep.” Adam
“This product made me really sick!” Lucy
“Made me feel like my heart would explode.” Rachael
“I go to sleep and get around 7 hours of sleep (just right for me). I was barely able to wake up the last 2 or 3 mornings without feeling like I had no sleep at all.” Stephanie
We’re keeping a close eye on one that’s not associated with harmful side effects, that’s backed by positive customer reviews. To learn more about Dietspotlight Burn, click above.
Stacker 2 Questions & Answers:
We summarized hundreds of user comments about Stacker 2 into this helpful FAQ.
What are the side effects of Stack 2?
According to user comments, Stacker 2 side effects may include anxiety, nervousness, jitteriness, increased heartrate, irritability, sleeplessness, upset stomach, headaches and shortness of breath.
What are the ingredients in Stacker 2?
Stacker 2 ingredients are yerba mate, caffeine, green tea leaves, guggulsterone, cassia mimosoides extract and white willow bark.
Does Stacker 2 work?
There’s no scientific research backing the effectiveness of Stacker 2. We found studies linking green tea and caffeine to weight-loss, but nothing specific to this formula.
How much does Stacker 2 cost?
Stacker 2 costs $19.99 on the official website.
How should I take Stacker 2?
You should take one Stacker 2 capsule, three times per day. Each bottle contains 100 capsules or about a 30-day supply. The company recommends not exceeding three pills per day.
What do users like about Stacker 2?
Some users like that Stacker 2 is a small capsule, making it easy to take and the affordability of the supplement.
What do users NOT like about Stacker 2?
We found that some users didn’t like the side effects from Stacker 2 and that the product didn’t help dieters lose weight.
If I take more Stacker 2, will I improve results?
No, you will not improve results if you take more Stacker 2.
How much caffeine is in Stacker 2?
Each serving of Stacker 2 contains 200mg of caffeine. 
Does Stacker 2 come with a guarantee?
There’s no mention of a guarantee with Stacker 2.
Do you know of any special deals or discounts on Stacker 2?
There are special deals and discounts on Stacker 2. You will receive free shipping on all orders of $50 or more. However, the last seveal months have flown by, considering our readers have been taking advantage of Dietspotlight Burn’s Special Trial Offer. Click above to learn more.
Stacker 2 Scientific Abstracts:
Data taken from in vivo studies showed that Yerba Mate has the ability to affect intake of food, resulting in elevated levels of energy expenditure, most likely an outcome of increased basal metabolism within mice given Yerba Mate. In vivo results from Yerba Mate treatment on lipid metabolism included decreases in serum triglycerides, serum cholesterol and glucose concentrations within test mice that were given a high-fat diet. It was concluded that Yerba Mate could possibly be a helpful tool in the treatment of obesity as well as diabetes. 
There is well documented evidence from animal and in vitro studies which outline the underlying mechanisms and biological actions of green tea and its catechins. There are human studies showing that green tea can be utilized to treat metabolic syndrome like obesity, type 2 diabetes, and cardio vascular conditions. When consumed long-term, green tea catechins may be helpful in fighting against high-fat diet induced obesity as well as type 2 diabetes. This could, in turn, significantly decrease risks of cardiovascular disease. There needs to be further studies which conform to the international standards that focus on the clinical and pharmacological effects of the tea and its catechins in order to confirm its mechanisms of action. 
Guggulsterone blocked TNF-alpha-induced endothelial tissue factor protein expression as well as surface activity. This occurred in a concentration-dependant manner and dexamethasone failed to have an effect on TNF-alpha-induced tissue factor expression. Guggulsterone was found to improve the endothelial tissue factor pathway inhibitor, weakening plasminogen activator inhibitor-1 and impairing vascular cell adhesion molecule-1 protein. Guggulsterone was found to suppress TNF-alpha-induced tissue factor mRNA expression, even more so, it weakened the activation of p38 and MAP kinases JNK. In vivo studies showed guggulsterone suppressing tissue factor activity as well as photochemical injury induced thrombotic occlusion in the carotid arteries of mice. It was concluded that guggulsterone, in vivo, blocked tissue factor expression in vascular cells and thrombus formation. It weakened vascular smooth muscle cell activation, thus making it a novel therapeutic tool for treating inflammatory diseases linked with an elevated risk of thrombosis. 
White Willow Bark
Salicin is found within white willow bark. Salicin is a chemical which resembles aspirin (acetylsalicylic acid). This, mixed with the plant’s anti-inflammatory activities (flavanoids), makes the plant responsible for delivering pain-relief along with anti-inflammation. White willow seems to trigger a relief in pain a little slower than aspirin; however, its effects can last much longer. 
- 1. Korean Association for Laboratory Animal Science. Anti-obesity and anti-diabetic effects of Yerba Mate (Ilex paraguariensis) in C57BL/6J mice fed a high-fat diet (2012). Korean Association for Laboratory Animal Science. November 21, 2016.
- 2. Beneficial effects of green tea: A literature review (2010). Chinese Medicine. November 21, 2016.
- 3. Guggulsterone, an anti-inflammatory phytosterol, inhibits tissue factor and arterial thrombosis (2009). Basic Research in Cardiology. November 21, 2016.
- 4. Willow Bark (2015). University of Maryland Medical Center. November 21, 2016.