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Zendocrine Review - 13 Things You Need to Know

Zendocrine detoxification blend is a new essential oil claiming to support the body’s natural ability to rid itself of unwanted substances, cleanse the body of toxins, support healthy liver function, and purify and detoxify systems of the body.

With more people turning to essential oil blends to promote overall health, our research team wanted to understand the benefits of Zendocrine better. Our research team spotlighted the ingredients’ benefits and potential side effects and turned our attention to research supporting the claims. Then, we compiled the data to give you the facts.

Zendocrine can be purchased through their Official Site.

Zendocrine Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Zendocrine?

Zendocrine is new to the doTERRA essential oils line of products. This detoxification blend offers a host of benefits, but primarily its uses include:

  • Supporting healthy liver function.
  • Detoxifying systems of the body.
  • Body system purification.
  • Supports the body’s ability to cleanse the body of toxins.

As a part of an essential oil regimen, Zendocrine is recommended to be used with Zendocrine softgels, Zendocrine detoxification complex, geranium essential oil, cilantro essential oil, and tangerine essential oil.

Let’s see what some of the ingredient research has to say about the components in this essential oil blend before diving deeper into the product:

  • HeliyonJuniper has strong antioxidant activity, which can give the berry a number of benefits.
  • Evidence-based Complementary and Alternative MedicineDue to the antioxidant activity in rosemary, the plant is thought to have neuroprotective effects.
  • BMC Chemistry: According to one study, “Lutein, zeaxanthin and β-cryptoxanthin, β-carotene, can be found in significant quantities in tangerines and oranges.”

Products Similar to Zendocrine


Who Makes Zendocrine?

The company behind Zendocrine is doTERRA International. doTERRA, Latin for “Gift of the Earth,” was founded in 2008. The company utilizes a direct selling model to promote essential oil blends to users throughout the world. Sellers of doTERRA essential oils are called Wellness Advocates and now exceed 2 million.

The company’s founders focus on offering high-quality essential oil blends, so families knew they were promoting products of the utmost quality and purity. doTERRA started by offering 25 single oils and ten essential oil blends and has since added detoxification blends and individual products to their essential oil regimen.

Zendocrine Customer Testimonials

What is an Essential Oil Blend?

Essential oil blends are volatile aromatic compounds found in the bark, flowers, roots, seeds, and stems of the plant. What is a volatile aromatic compound? They are small organic molecules changing from a liquid or solid state into a gas, all at room temperature. When volatile aromatic compounds move through the air, they, in turn, affect the sensory glands, making essential oil blends ideal for use in aromatherapy.

According to the National Institute of Environmental Health Sciences, essential oils are concentrated plant extracts derived through distillation or mechanical pressing. The essential oil blend retails the flavor and smell of the source.

There’s research supporting the benefits of essential oils. According to the journal Evidence-based Complementary and Alternative Medicine, “at least 90 essential oils can be identified as recommended for dermatological use, with at least 1500 combinations.”

Zendocrine Benefits

While doTERRA offers key benefits of Zendocrine, there are additional benefits of essential oil blends. The primary benefits of Zendocrine include:

  • Body system purification.
  • Cleansing the body of toxins.
  • Supporting healthy liver function.

Additional benefits of essential oils include:

  • Complementary treatment to massage therapy and acupuncture.
  • Positive effects on nausea and vomiting.

Zendocrine Ingredients

Zendocrine ingredients are listed in a proprietary blend, including:

  • Tangerine peel
  • Rosemary leaf
  • Geranium flower/leaf
  • Juniper berry
  • Cilantro herb

Tangerine Peel

Tangerine, as with other citrus fruits, has been studied extensively for its health benefits. However, we couldn’t find a lot of research on the ingredient.


Rosemary is used in culinary dishes throughout the world, but also offers health benefits. According to the journal Evidence-based Complementary and Alternative Medicine, “uses of rosemary are antibacterial, antioxidant, improving cognitive deficits, and anti-inflammatory.”

Additionally, the journal Psychiatry Research found “smelling rosemary increases free radical scavenging activity and decreases cortisol levels.”


Geranium is an essential oil studied for its benefits on stress reduction. According to the Journal of Caring Sciences, “Aroma of essential oil of geraniums can effectively reduce [stress]…and can be recommended as a non-invasive anti-[stress] aid.”

Juniper Berry

Juniper is native to Europe, North and South America. According to the journal International Scholarly Research Notices, juniper has been used in “herbal medicine…as [an] antidiarrheal, anti-inflammatory, astringent, and antiseptic.”

Research presented in the journal Antioxidants concluded, “antioxidant research of juniper essential oil provided the existence of several mechanisms which enabled [free] radical scavenging.”


Cilantro is another plant often used in culinary dishes possessing both nutritional and medicinal properties. Based on research presented in the journal Fitoterapia, cilantro offers “anti-inflammatory properties.”

Zendocrine Uses

Aside from the claimed benefits of Zendocrine, uses of the essential oil include:

  • Aromatic
  • Topical
  • Internal

Further Details on Claimed Zendocrine Benefits


As a part of an aromatic essential oil regimen, users will add Zendocrine to a diffuser of their choice. You’ll add three to four drops of Zendocrine to your diffuser.


Zendocrine can be used topically. You can create a Zendocrine detox bath by adding three or four drops to your bath. Some also add Epsom salts as well. An additional topical application of Zendocrine is applying directly to the skin. The company recommends applying one to two drops to a particular area. doTERRA suggests diluting Zendocrine with a carrier oil (fractionated coconut oil) to minimize skin sensitivity.


You’ll add one to two drops of Zendocrine to your citrus drinks, water, or tea. doTERRA suggests diluting one drop in four ounces of liquid before adding to a dink.

Zendocrine Side Effects

Instead of focusing on the side effects found in Zendocrine reviews, our research team turned their attention to the potential side effects of Zendocrine ingredients.

Tangerine Peel

One of the potential side effects of using tangerine essential oil is skin reactions. According to the International Journal of Molecular Sciences, “To avoid any possible adverse skin reactions, it is recommended to dilute Citrus oils with a carrier oil before topical use.”

Something often missed regarding side effects from a tangerine essential oil is the potential interaction with prescription medication.

Rosemary Leaf

While there’s no mention of the adverse effects of using rosemary essential oil, there are some positive side effects. According to the journal Scientia Pharmaceutica, in an animal study, mice were exposed to “.5 mL of rosemary for a period of an hour [resulting] in the locomotive activity of mice was increased.”

Geranium Flower/Leaf

Some users may notice the side effects of this particular ingredient. However, according to the Dental Research Journal, research has “not observed any reportable side effects in patients receiving Geranium.”

Juniper Berry

According to SAGE Journals, some reported side effects of juniper include “difficulty in breathing, wheezing, and coughing.”


Cilantro is generally safe to use. However, according to the Indian Journal of Pharmacology, cilantro may have a “sedative” effect.


Zendocrine Warnings

There are warnings and cautions mentioned on the official website regarding Zendocrine.

  • Possible skin sensitivity.
  • Keep out of the reach of children.
  • Consult a doctor if you’re pregnant, nursing, or under the care of a doctor.
  • Avoid contact with the eyes, inner ears, or sensitive areas.

doTERRA International received a letter in 2014 from the U.S. Food & Drug Administration regarding several of doTERRA essential oils, including rosemary, lemon, and geranium, among others. The letter stated some doTERRA essential oils were “promoted for conditions that cause them to be drugs.”  The statements have since been corrected on the official doTERRA website.

Where to Buy Zendocrine

You can buy Zendocrine from the official doTERRA store. You’ll spend:

  • 15-milliliter bottle – $32.00

Customers signing up for a wholesale account receive a 25 percent discount; lowering the price to:

  • 15-milliliter bottle – $24.00

Zendocrine Pros and Cons


  • There is research to support the health benefits of some ingredients in Zendocrine.


  • May cause skin irritation.
  • Science shows possible side effects.
What Users Are Saying

What Users Are Saying

“I used this to detox my body after having Covid. After a month, I was still struggling to catch my breath and having no stamina. I doubled up on the daily dosage, and in just the first few days I’m seeing a remarkable improvement.”

“This is a great detox oil. Doesn’t taste great, but it’s tolerable.”

“I really enjoyed the flavor of this oil blend, but for some reason it caused the worst pimples/rash all over my shoulders and back. I’d been taking 1 drop in the morning with water. A week after I stopped taking it, the pimples started to go away. Super weird considering I was taking it for detoxification!”

Zendocrine Ingredients
Bottom Line

The Bottom Line on Zendocrine

Zendocrine is a detoxification blend from doTERRA International with claims to cleanse the body of toxins, promote body system purification, and support healthy liver function. The concern, based on research, is no studies are supporting the claims of body system purification.

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Is Zendocrine for weight loss?

No. Zendocrine is an essential oil from doTERRA claiming to help detox the body.

What are Zendocrine ingredients?

Zendocrine ingredients include tangerine peel, rosemary leaf, geranium flower and leaf, juniper berry, and cilantro essential oils.

Are there any Zendocrine side effects to worry about?

Based on its ingredients, potential side effects of Zendocrine include skin irritation, sleepiness, and potential drug interactions.

Is Zendocrine safe?

Although Zendocrine is potentially safe to use, it is important to note that skin sensitivity is possible. Stay out of reach if you are pregnant or under 18. It is important to talk to your medical doctor before using this essential oil.

Are there any free samples or trials for Zendocrine?

Currently, there are no Zendocrine free trials or samples available.

Where can I buy Zendocrine?

Zendocrine can be purchased using their Official Site.

How do I contact the Zendocrine customer service?

You can contact doTERRA, the makers of Zendocrine, by calling 800-411-8151 or e-mailing service@doterra.com.

What is the most common complaint of Zendocrine?

The most common complaint of Zendocrine is the lack of benefits caused by using the product.

What are some similar products to Zendocrine?

Other products similar to Zendocrine include DigestZen, Advocare Cleanse, Lectin Shield, and Colonix.

Article Sources

4 Zendocrine Reviews

  • I highly recommend you giving Zendocrine a try. You’ll be glad you did
    Cynthia (Verified Purchase)

    I have been taking the Zendocrine soft gels for several months. I’m have severe RA and the medication I have been taking has both pros and cons. Zendocrine has helped relieve inflammation making mobility a bit easier. it also help’s keeping me “ Regular” ( ; It doesn’t make you go- it helps you to go, if that makes sense. But the most noticeable difference is I am so much more relaxed, I mean I was always feeling irritable and frustrated with no explainable reason why. With Zendocrine I feel so calm and yes there is a bit more willing and wanting to go do…. anything! I take it twice daily. I do recommend that you drink a full glass of water when taking.

  • Type 2 diabetes
    Aileen Collom

    Can someone with type 2 diabetes use this oil?

    • Luis (Editor)

      Hi Aileen! We recommend checking with your physician before using this supplement to make sure they are safe to take.

  • Iancu Elena (Verified Purchase)

    Used properly, Zendocrine is definitely working. At least 5
    10 people have noticed positive effects after using it for at least 2 weeks. For example, the parasites have been reduced to a half after only 20 days with Zendocrine, along with other negative symptoms ! I definitely recommend it!

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