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Lipodrene Review - 11 Things You Need to Know

Lipodrene, the “Yellow Hexagon,” is the first diet pill and fat-loss formula from Hi-Tech Pharmaceuticals. The product relies on ephedra, which is currently banned from sale in the United States due to dangerous side effects. While Hi-Tech claims that this product has been engineered based on “volumes of scientific and clinical data with hundreds of published studies by the most prominent Universities and Medical Journals,” Hi-Tech does not cite any of these studies or explain why the secondary ingredients in Lipodrene were added to the formula.

It seems to us that the product relies heavily on ephedra, which as we will explain is not only potentially dangerous but also potentially ineffective for fat loss. Read on to get the Bottom Line on the product.

Lipodrene can be purchased through their Official Site.

Lipodrene Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

Lipodrene Video Review


What is Lipodrene?

Lipodrene is a weight loss supplement that claims to suppress your appetite, burn fat, and boost metabolism. Advertising presents it as an energy enhancer that can keep users alert and ready to work out and stay active. It is one of the countless products on the market that claims to provide these benefits to help users lose weight fast, but are the ingredients effective?

  • The Journal of the American Medical Association – “Ephedrine and ephedra promote modest short-term weight loss (approximately 0.9 kg/mo more than placebo) in clinical trials. There are no data regarding long-term weight loss, and evidence to support use of ephedra for athletic performance is insufficient. Use of ephedra or ephedrine and caffeine is associated with increased risk of psychiatric, autonomic, or gastrointestinal symptoms, and heart palpitations.”
  • FASEB – As for Senegalia berlandieri extract, also known as acacia rigidula, we see antimicrobial activity, but no recent research supports weight-loss claims.
  • International Journal of Obesity – As for caffeine, some people report decreased appetite and scored higher on assessments, in clinical research after taking the stimulant.

Consumers may recognize it as the yellow hexagon, the weight loss pill that has become quite iconic. This product has been available to the public for more than fifteen years. While it is known as a classic in the weight loss supplement industry, it also faces its fair share of controversy. Some of the ingredients used in these products have come under review and are on the ban list.

Lipodrene is produced by Hi-Tech Pharmaceuticals, a company based in the United States. Hi-Tech Pharmaceuticals, founded in 1994, is also a CGMP certified company, which means that it abides by the FDA’s current acceptable manufacturing practices.

Lipodrene Competitors

Stimerex ES
Other similar products: , TruControl

Lipodrene Benefits

Lipodrene weight loss supplements claim to offer some key benefits, despite the existing hazards. The benefits include:

  • Boosts energy
  • Enhances fat burn
  • Enhances metabolism
  • Suppresses appetite

Among its many reported benefits, Lipodrene tips the scale downward and helps users reduce their body fat by revving the metabolism, supplying more energy for activity, and suppressing appetite to keep fatty foods at bay. While these benefits are all possible gains from this supplement, it is vital to keep in mind that it’s not the only supplement offering these changes.


Lipodrene Ingredients

Lipodrene uses ingredients that claim to target fat burn and energy enhancement. Lipodrene attaches to alpha2 receptors (which are abundant in the hips, thighs, and buttocks). The ingredients also target metabolism. Being a thermogenic and an energizer, it would, ideally, resulting in fast weight loss. Ingredients include:

  • Ephedra Extract
  • Senegalia Berlandieri Extract
  • Phenylethylamine HCl
  • Synephrine HCl
  • Theobromine
  • Green Tea Extract
  • Hoodia Extract
  • Caffeine
  • Extend-Rx technologies 560mg

Most of the ingredients on the Lipodrene label are included as components of their proprietary blend. Each tablet contains 560 mg of the proprietary blend and 100 mg of caffeine. The Lipodrene proprietary blend also contains a host of other ingredients, such as 5-Methoxytryptamine HCl and Yohimbine HCl, but we’ll focus on a few key ingredients to give you a brief idea of how this product works.


Caffeine is included in this supplement to provide an extra boost of energy and to help users shed fat and lose weight. Most people use the caffeine contained in teas and coffee as a morning stimulant to start their day, and the benefits of caffeine are well known. Caffeine helps with alertness, and it can also provide the extra energy boost that people need to get active and workout.

The additional energy and other benefits that lead to weight loss is not mere speculation. Several studies have documented that the use of caffeine leads to a reduction in fat and overall body weight. One study that tracked overweight women concluded that caffeine intake helped them to be more active and have more energy.

Ephedra Extract

Ephedra comes from the Ephedra sinica plant which has been used in traditional Chinese medicine for thousands of years. Many people are concerned about the connection between Ephedra and Ephedrine and the potential side effects that may result from continued use. However, Ephedra is used for its scientifically backed ability to help people lose weight.

The effects of Ephedra on weight loss have been tracked and documented by several studies, many of which study the effects of Ephedra and caffeine together. The same study that documented caffeine use for weight loss in women also required participants to use Ephedra supplements. The Ephedra combined with caffeine resulted in verified short-term weight loss.

Another study on obese participants, published in the journal Obesity, also concluded that Ephedrine combined with caffeine results in the significant fat mass reduction and weight loss. However effective this ingredient may be for weight loss, it is advisable to proceed with caution when using ingredients like Ephedra. The following sections in this guide will explain why.

Synephrine HCl

Synephrine is an ingredient used in some weight loss supplements, according to the British Journal of Clinical Pharmacology


Theobromine is a nitrogenous organic compound of the cacao plant. It is commonly found in chocolate, tea leaves, and cola and produces certain effects on the body that are similar to those produced by caffeine, according to Frontiers in Pharmacology. It is a natural diuretic.

Green Tea Extract

Green tea helps to protect the body by delivering antioxidants, according to Molecular Nutrition & Food Research. Green tea is typically consumed as a drink, and green tea extract is often used in supplements like Lipodrene as well. People have known for years that green tea offers health benefits, and it can also help people lose weight by increasing metabolic rate.

Some studies have recorded positive results that document green tea as a good agent for reducing fat and weight loss. While the effects are small, they are significant enough to boost the body’s ability to burn fat at a quicker rate. Additionally, the NCCIH noted that green tea could increase mental alertness.

Hoodia Extract

Hoodia extract comes from the hoodia gordonii cactus that is native to various regions of Africa, according to LiverTox. It is often used in folk medicine and contains some properties that could make its inclusion integral in Lipodrene’s proprietary blend. Claims have been made that this plant acts as an appetite suppressant, but many believe that these claims are false.

Additionally, research published in the Journal of Ethnopharmacology found that only one study actually mentions hoodia acting as an appetite suppressant.

One study found that participants who took hoodia experienced no significant changes in weight or energy. They did, however, experience adverse side effects including increased heart rate and nausea. Some believe that the adverse side effects are what contribute to resulting weight loss, and hoodia extract have yet to be approved by the FDA.

What Does Lipodrene Do?

The proprietary blend ingredients claim to play critical roles in “reducing fat, increasing energy, and suppressing appetite.”

Lipodrene claims to stimulate “lipolysis” or the release of fat. It also serves to inhibit “lipogenesis” or the storage of fat. It inhibits the discharge of targeted enzymes that control fat storage while also stimulating cellular energy, effectively causing the individual fat cells to release unwanted fatty acids.

The caffeine in Lipodrene diet pills provides users with more energy so that they can exercise more actively. This stimulates activity and fat burn without any calories that come with a latte or piece of chocolate. Caffeine also acts as a Lipodrene appetite suppressant, helping to reduce the caloric intake of users. Lipodrene contains this energizer that enhances workouts and should be used to enhance a regular exercise routine.

Does Lipodrene Work?

When asking questions about Lipodrene does it work and is it safe, there are only a few things that can verify this. One is science, and the other is Lipodrene reviews. Science gives an objective view of how a product works and whether it can work the way the manufacturer claims it does. We reviewed the main ingredients of Lipodrene and provided the results back by clinical data that are either back up or refute the reputations of some of these ingredients and their roles in weight loss. User reviews provide a deeper understanding of the varying results that can occur when used by real people.

Caffeine, Ephedra, and other ingredients have been studied and tested for weight loss acceleration and facilitation, and their effects have been verified. Other ingredients, such as hoodia extract, remain unverified and even questionable. It should produce some results when taken as directed, given the ingredients that are inside. However, this doesn’t mean that it will work.

Side Effects

Lipodrene Side Effects

Users of Lipodrene could be at risk for side effects that range from mild to moderate. While many users don’t experience side effects, others may notice side effects from Lipodrene ingredients, including:

  • Difficulty sleeping
  • Interactions with medications
  • Nausea
  • Dizziness

Is There a Lipodrene Alternative?

There are many alternatives to Lipodrene if you’re looking for a weight loss pill that can help burn fat and boost your metabolism. A simple caffeinated drink might give you the boost of energy that you’re looking for.

Hi Tech Pharma offers other versions of Lipodrene, including Lipodrene Elite, Lipodrene Hardcore with Ephedra, and Lipodrene Xtreme V2.0.

Products that we’ve reviewed and are similar to Lipodrene include Hydroxycut and OxyElite Pro.


What Does Lipodrene Cost?

Lipodrene by Hi-Tech Pharmaceuticals comes at varying prices, depending on where you shop. Lipodrene is also available on Amazon.

  • Supplement Warehouse: $34.95
  • Ephedra Warehouse: $34.95
  • NetNutri: $34.95
  • Official website: $69.95

Lipodrene Directions

Lipodrene pills should be taken as directed on the label. The maximum dosage is 2640 mg per day or four pills. However, the official recommended dosage is three pills per day. Users should take one to two pills in the morning and one pill after lunch. Taking pills in the evening may interrupt sleep and should be avoided.

  • One to two tablets in the morning and one tablet after lunch
  • Do not exceed four tablets daily
  • Take up to eight weeks (requires two bottles)
  • Men & women can take this product
  • One bottle will last 33 days at the max dose of three tablets per day

Lipodrene FDA and Lawsuits

Hi-Tech Pharmaceuticals has a history of controversy. In 2008, Hi-Tech Pharmaceuticals was barred from making misleading statements about their diet supplements. They also had to warn consumers about the potentially dangerous ingredients in their products. According to the Federal Trade Commission, they ignored the court order and had to pay $40 million in damages to consumers.

In 2009, the High-Tech CEO, vice president, and founder were all sentenced to 18 months in prison to run an illegal online pharmacy. According to NBC News, the trio could have served up to 20 years, but they reached a plea with the prosecution. The plea deal allowed Jared Wheat, High-Tech’s CEO, to remain in charge of the company.

In 2015, the FDA contacted Hi-Tech Pharmaceuticals concerning information that BMPEA was found in Fastin-XR and Lipodrene Extended Release. The FDA demanded that Hi-Tech remove the ingredient from all supplements. Hi-Tech refused to comply.

Instead of complying with the FDA, Jared Wheat sued the Harvard researcher, who initially found the illegal substance in Hi-Tech Pharmaceutical supplements. Wheat claimed the negative press his company was receiving should be considered libel.

According to a Business Insider report, the Harvard researcher, Dr. Pieter Cohen, won the case, but the trial was long and expensive. Critics saw the frivolous lawsuit as a way for Wheat and Hi-Tech Pharmaceuticals to intimidate other academics investigating the growing supplement industry.

On April 10, 2019, the FDA sent another warning letter to Hi-Tech Pharmaceuticals. The letter addressed concerns that several Hi-Tech supplements contain another potentially dangerous ingredient. Lipodrene Elite, HydroxyElite, and Ultimate Orange all have Dimethylhexylamine.

Dimethylhexylamine may cause serious side effects similar to those of dimethylamylamine. Dimethylamylamine is capable of generating a heart attack or stroke in previously healthy individuals.

Instead of complying, Jared Wheat and Hi-Tech Pharmaceuticals sued the FDA. On May 3, 2019, filed a lawsuit against the FDA for intimidation. In June 2019, the FDA was ordered to return five truckloads of DMAA to Hi-Tech.

However, in an exciting twist, the FDA was notified it had properly seized the DMAA ingredient on August 30, 2019. This was because DMAA is a food additive, not a dietary supplement, as Hi-Tech had argued.

Unfortunately, the company has continued to get into trouble with the law. Although Hi-Tech Pharmaceuticals already received a warning from the FDA regarding dimethylamylamine (DMHA), the company continued to use it.

On November 2, 2019, the company was sued for using DMHA in a long list of supplements, including Ultimate Orange, Fastin-XR, Lipodrene Elite, Lipodrene Hardcore, Lipodrene Xtreme, and Hydroxyelite.

On May 19, 2020, the FTC started issuing $8.5 million in refund checks to consumers who bought Lipodrene, Spontane-ES, and Thermalean due to the supplements making fraudulent claims.

What Users Are Saying

What Users Are Saying

“Great. – It really takes the pounds off.”

“Not for me! – Unfortunately this product made me sick each time I took it, along with feeling wired.”

“My wife & I both use these tablets for extra energy and have loved them for years. Try them! (They pack a good punch, so smaller folks might want to only take half of a tablet.)”

Bottom Line

The Bottom Line on Lipodrene

Lipodrene has been one of the more controversial weight loss supplements over the last fifteen years. Because of its dangerous side effects and shady reputation, it’s may be a good idea to think twice about this one, no matter how badly you want to lose weight. Many other products are more natural and subtle that can boost energy and help burn fat without any negative side effects. Whatever short-term weight loss it may provide, it’s not necessarily worth the risks.

When you want to lose weight, making lifestyle changes is one of the first steps. Those lifestyle changes can help you lose weight immediately, but you need to stick with them for the long haul to keep the weight off. That’s where weight-loss apps come and play.

Among the best weight loss apps we’ve seen this year is Noom. With Noom, you get real human coaching, personalized meal plans and expert articles and wellness advice. The program is clinically proven to help you lose weight and keep it off.

Dietspotlight readers can give Noom a try as part of a free trial offer for a limited time.

Learn More About Noom »
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What are the side effects of Lipodrene?

Based on some customer reviews, possible Lipodrene side effects include vomiting, heart palpitations, nausea, dizziness, headache, jitters and sleeplessness. Some of these side effects are due to the ephedra in the supplement.

What is in Lipodrene?

Lipodrene ingredients are ephedra extract, acacia rigidula extract, phenylethylamine alkaloids, methylsynephrine, b-phenylethylamine, n-mehtyl-b-phenylethylamine and r-beta-methylphenylethylanine, phenylethylamine hcl, synephrine hcl, theobromine, green tea extract, 1,3 dimethylamyline hcl, hoodia extract, cassia nomame extract, naringen, 6,7 dihydroxybergamottin, 5-methoxytryptamine hcl, l-5-hydroxytrptophan, yohimbe hcl, caffeine anhydrous, dextrose, microcrystalline cellulose, hydroxypropyl methylcellulose, stearic acid, magnesium stearate, sodium starch glycolate, starch, triacetin, titanium dioxide, fd&c yellow #5 lake, silica and fd&c yellow #6 lake.

What is the active ingredient in Lipodrene?

The active ingredient in Lipodrene is ephedra.

Does Lipodrene work?

The stimulants in Lipodrene, which include ephedra, green tea, caffeine and synephrine hcl should help boost metabolism and increase energy levels. While some have been studied, there’s no evidence that the blend actually is effective as it relates to weight-loss.

How much does a bottle of Lipodrene cost?

A bottle of Lipodrene costs $8.95 for 20 tablets and $39.95 for a 100 count. Depending on your usage, a jar lasts between three and 30 days.

Where can I buy Lipodrene?

Lipodrene can be purchased using their Official Site.

How do you take Lipodrene?

You should take one or two Lipodrene tablets each morning and another mid-day. The company recommends not exceeding four in a 24-hour period.

Who makes Lipodrene?

The makers of Lipodrene is Hi Tech Pharmaceuticals.

Can I take Lipodrene with coffee?

Since Lipodrene contains a significant amount of stimulants, it’s best to avoid taking this product with coffee and other sources of caffeine.

How much caffeine is in Lipodrene?

Each Lipodrene  capsule contains 100mg of caffeine. If you follow the directions, you’ll consume 300mg per day.

Is Lipodrene with ephedra safe?

Ephedra is banned in the United States due to its potentially severe side effects. Therefore, Lipodrene with ephedra is not considered safe.

Do you take Lipodrene on an empty stomach?

Yes, you should take Lipodrene on an empty stomach.

Article Sources

92 Lipodrene Reviews

  • Lipodrene in India

    Where will I get this product in Mumbai (India)

    • Cameron (Editor)

      They may not have retailers or distributors there. We have listed contact information for this company in the FAQ section.

  • Don't know if will keep this
    Margaret (Verified Purchase)

    Started taking these yesterday. At first I loved them because they really did make me not want food, but this morning, I took one and threw up less than an hour later. I don’t know if I’ll keep taking them.

    • asheba

      Do you still take them

    • Lucita

      Take 1/2 pill first or with a little bit of food until you body’s getting used it. 2 is too much!!!

  • this product does work 4sure
    maryjane (Verified Purchase)

    Im on lipodrene It has been prtty awesome Ive lost a few pounds the first week. totally curbs your appetite and it makes me want to go out and do things. Working out in the gym longer and harder i would reccomend this it takes a few days for your body to get immune to it… but this product does work 4sure!!!

    • Prado

      Took one and half morning and one after lunch on first day , very dumb move. Shocking sleep and heart racing all night. Second day will just be one in the morning and try again.

  • force myself to eat
    Beth (Verified Purchase)

    I have taken this and love it have lost 86 pounds on it and I have to force myself to eat!!!!

    • Crystal

      how long were you on these to loose 86 pounds?

    • TMac

      That’s awesome. I’ve been taking it for about 3 weeks with no weight loss. However, I’ve lost Los of inches. I do crossfit 3 to 4 times a week along with biking and running. It definitely gives me energy. I will keep taking them with hopes of shedding some pounds.

    • stacey

      Leave a comment…that’s great! I have been onit for 3 weeks and haven’t lost anything.

      • Amy Knudsen

        The first time I took this I truly thought I was dying. Throwing up, diarrhea & terrible splitting headache. However, After about 4 weeks I read that some start with 1/2. I took it on an empty stomach in the am. OMG no side effects except sleep disruption. I also stupidly drank a nitro coffee late in the day. Now for the best: I ate 1 meal mid day & was not hungry the rest of the day & no sugar or carb cravings!!!! Before no matter what I craved sweets & salty crunchy snacks especially at night. I peed & peed all night…like it was burning fat & bloating. No cravings…appetite suppressed. I tried ice cream usually not stopping until finished with the pint & had 3 bites. It tasted terrible. I feel more focused & energetic. Next day took half in am & another half about early mid day. For me ramping up, thanks to posting here, is the key. I’m excited to see if I lose fat.

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