Synedrex Review - 13 Things You Need to Know
With only one pill a day, Synedrex claims it can help you increase energy levels and the metabolic rate. The pill claims to be “the most powerful thermogenic agent on the market.” Upon further research into their ingredient list, including bitter orange and hordenine, it is clear that science may not back these claims.
Our research team looked into their “scientifically researched and proven ingredients,” product warnings, and the discounts available online and in-store to learn more about this diet pill. In the end, we compared the ingredient research on Jarensis extract and Yohimbe to the customer reviews on the Metabolic Nutrition official website to see if this is worth the money.
Synedrex can be purchased through their Official Site.
Synedrex Video Review
What is Synedrex?
Synedrex pills are marketed as a thermogenic supplement designed to burn fat and boost your metabolism to reduce weight and inches.
Synedrex pills are sold via the web both from the manufacturer’s website and several other online retail sites, and this is what the research has to say about the ingredients:
- Lipids in Health and Disease: A dietary supplement containing primarily higenamine was able to increase energy, heart rate, and blood pressure, according to one study.
- Acta Pharmacologica Sinica: Research using animal studies found that huperzine-A could improve cognitive performance in obese subjects.
- Journal of Nutritional Science: Grains of paradise may be able to reduce body fat.
How Did Synedrex Start?
There is no information available as to when Synedrex was first marketed.
Synedrex original was manufactured with the, now banned, chemical DMAA. This formulation was withdrawn with the banning of DMAA, and Synedrex’s new formula was brought onto the market.
The manufacturer is Metabolic Nutrition Inc, based in Tamarac, Florida. The company manufactures and sells a range of nutritional supplements that include weight loss supplements, vitamins, and other health and muscle mass supplements. Their products include Protizyme, Tri-pep, Musclean, Hydravax, E.s.p. Extreme, Carni-10, Myogrow, and they also offer lifestyle gear.
Metabolic Nutrition Inc. Customer service contact information:
10151 NW 67th Street
Tamarac, FL 33321
1-800-626-1022 9:00 am – 5:00 pm EST, Monday through Friday.
Scroll below for one of the best products we’ve seen over the last year.
The manufacturer claims that Synedrex weight loss pills have been scientifically engineered to ensure that all the ingredients work synergistically to ensure that the user maintains their energy levels and avoids the energy slump common with the use of products that contain powerful stimulants.
The manufacturer claims that Synedrex weight loss is possible. Still, the product will energize you, suppress your appetite, accelerate your weight loss, enhance your mental clarity and concentration, and improve your mood.
The manufacturer also claims to use ingredients that are scientifically researched and proven in this product.
When looking at the weight loss section, a similar set of blog-style articles was found but no scientific research.
The articles listed are not current, and this site is infrequently updated. The latest four articles are dated April 2016, October 2016, and December 2016.
Metabolic Nutrition also touts the Thyrene and Synedrex stack to boost your weight loss regime.
The claim is that the consumer “will lose weight with the Synedrex weight loss pills, but by taking Thyrene at the same time, you will improve your thyroid function, which will aid in boosting your metabolism.”
Thyrene is not a stimulant, so, according to the manufacturer.
The Synedrex weight loss pill claims to be a successful weight and inch loss formulation. The Synedrex ingredients in this product are:
- Caffeine Anhydrous
- Eria Jarensis Extract
- Grains of Paradise
- Bitter Orange
- Yohimbine HCL
- Huperzine A
Additional Information on the Ingredients
Anhydrous caffeine is nothing more than dried caffeine available in a powder form that has many uses.
Caffeine is listed as a nervous system stimulant and is defined as being a substance that will be habit-forming rather than one that is addictive, according to the journal Brain Research Reviews.
The problems arise when someone that regularly takes large intakes of caffeine stops; they may be subject to withdrawal symptoms such as nausea, headaches, and fatigue.
The International Society of Sports Nutrition claims that caffeine is beneficial for athletes engaged in extended exercise (endurance races) and high-intensity exercise (rugby or football) rather than strength exercises such as weightlifting.
Synedrex has 300mg of caffeine in one capsule as stated on their website.
To give some idea of how high this is, a coffee cup will contain between 50 and 475mg dependent on the brewing process, while cola drinks have 0 to 115mg per 12oz serving.
Eria Jarensis Extract
The Eria Jarensis extract comes from the Eria Jarensis orchid and is also known as N-Phenethyl Dimethylamine or N, N-Dimethylphenethylamine.
This is another stimulant gaining popularity as a replacement for banned substances such as ephedrine, DMAA, and AMP-Citrate.
Grains Of Paradise (Paradoxine)
Grains of Paradise comes from the fruit and seeds of the Aframomum melegueta plant.
There are very few studies that show what this herb does. Some preliminary work on the herb has indicated that it may stimulate the brown adipose tissue, leading to weight loss, but this study has only been done in rats.
Another study completed on rats has some inconclusive findings showing that this may have weight reduction possibilities, according to Autonomic Neuroscience, but the results must be replicated in human studies.
Bitter Orange Extract
Bitter Orange (Citrus Aurantium) is also known as Seville Orange, or Sour Orange, and comes from a tree native to the Mediterranean, but it is now grown worldwide. Its medicinal properties have been known for centuries, and it was originally used for constipation, cramps, and stomach pain.
In more recent years, it has gained popularity as a weight-loss supplement, and though there is some scientific support for its effectiveness in weight loss, there is debate over its safety.
This debate revolves around the alkaloid synephrine, which has a similar molecular structure to ephedra, a drug banned by the Food and Drug Administration.
According to the University of Michigan Medicine, there is insufficient data to establish clearly whether or not Bitter Orange will have the same effect as ephedra at this time.
Yohimbine HCI is a chemical extracted from the bark of the Yohimbine tree native to West Africa. The chemical has been traditionally used to manage erectile dysfunction in men as it enhances the blood flow to the genital area.
Its effectiveness in weight loss stems from some preliminary work done that shows that ingesting this chemical before exercise, specifically soccer in this study, may increase the possibility of stubborn fat deposits being broken down, according to Research in Sports Medicine.
Higenamine is a chemical extracted from plants such as nandina bamboo, Chinese aconite, and Lamarck’s Bedstraw. Its use is associated with being a fat burner.
Other ingredients include Hordenine, Huperzine A, Naringin, N-Methylphenethylamine, L-Dopa (stand 99%), and Poly-Thyronine.
Does Synedrex Work?
Synedrex reviews for this product are mixed, and as they are all based on anecdotal evidence, it is difficult to determine whether the product works or not. The scientific pages on the website are all blog-type pages and give no links to any scientific research. There are means of contacting a scientist directly by filling in an inquiry form on the web, but there is no indication of the scientist that will answer the question and whether they are qualified or not.
As stated, there are some positive Synedrex reviews for this product. Still, some of the individual ingredients are powerful stimulants and many customers reported unpleasant side effects after taking the product.
The Synedrex fat burner has received some positive reviews on the net, but as has been previously stated, there is no proof that the product burned the fat or if it was a simple change in lifestyle that was responsible for the change.
Some of the individual ingredients have been the subject of alternative tests. For example, Bitter Orange was the subject of a project documented in Current Therapeutic Research.
In this project, a group of test subjects was given a combination of caffeine, bitter orange, and St. John’s Wort while a control group was given a placebo. The combination pill group was found to have lost a significant amount of weight during the six-week study.
Synedrex bodybuilding is advocated on some forums for use in the bodybuilding arena. The claim is that the product’s energizing effect will assist with the rigorous exercise routines that bodybuilders undertake.
Perhaps the best place to start would be to use one of the Synedrex coupons that are available via websites such as Couponsock and Dontpayfull.
Taking advantage of Synedrex coupons will allow you to purchase the product at a reduced price and see if the product suits your requirements or not before paying the full price. Another option along the same lines is to look for advertised free Synedrex samples.
These Synedrex samples will allow you to try a small amount of the product and again, decide if you like them or not.
Details On Synedrex And Weight Loss
The Synedrex weight loss pill is a capsule that should be taken in the morning.
No two people will react the same way to any compound, so the expected increase in your metabolic rate and the fat that you should burn may or may not happen depending on your circumstances. Many reviewers claimed to have lost no weight while using the product but others claim to have lost weight.
Those who lost weight did not give details about whether they had adjusted their diet and exercise routines while taking Synedrex weight loss pills, so there is no proof that the product was the reason for the lost weight or altered diet and exercise programs contributed to the weight loss.
The company website does have many articles on how to exercise and follow a healthy diet, so it is likely that if customers follow the suggested eating and exercise plans, they could lose weight.
How To Use (Take) Synedrex
The Metabolic Nutrition website advises that Synedrex is a strong compound and that consumers should take one capsule a day in the morning along with your breakfast. They advise that the capsule should not be taken within 6 hours of your normal bedtime as it may interfere with your sleep.
The website also advises that you drink plenty of water during the day, and one of the common complaints about this capsule was that consumers suffered from feeling thirsty all day.
Metabolic Nutrition also advises that it is good practice to stop using the product every eight to twelve weeks to allow “the body to reset itself.”
Metabolic Nutrition claims that Synedrex weight loss pills can be taken in conjunction with other Metabolic Nutrition products but advise against taking it with any other company’s product.
The website states that this product is not suitable for pregnant women, lactating mothers, prepubescent children, or anyone who suffers from a pre-existing health condition affected by a high stimulant product.
Synedrex should not be taken with any other weight loss supplements.
Potential Synedrex Side Effects
Many reviews on the web indicate that there is a possibility of serious side effects when taking this product.
The reported side effects that can be attributed to some of the ingredients include:
- Sleeping issues
- Elevated heart rate
Caffeine is a stimulant for the central nervous system and is in the same class as a methylxanthine. Too much caffeine can lead to jitteriness, a feeling of being shaky on the legs, excessive sweating, and sleeping issues. It can also lead to an increased heart rate.
Children are known to be very sensitive to yohimbine. If you are taking any medications, do not take yohimbine as it can increase the side effects.
FD&C Blue 1 and FD&C Red 40
These are two food colorants, and both have been the subject of warning notices.
Synedrex Product Warnings
The Synedrex label warns:
- Not to exceed the stated daily dose
- Not suitable for pregnant or lactating mothers
- Not suitable for anyone under the age of 18
- Not to be taken in conjunction with alcohol or caffeine
Any Synedrex Lawsuits?
According to Top Class Actions, Syndrex was named in a class-action lawsuit in 2017. The lawsuit alleged that Metabolic Nutrition knowingly added an illegal ingredient, methylpentane citrate, to the formula. We didn’t find the ingredient listed on the label as of early 2019.
Where Can You Buy Syndrex and How Much?
You can purchase Synedrex on the Metabolic Nutrition website and other supplements and general retail locations.
- Metabolic Nutrition: $49.99
- Walmart (45 capsules): $33.90
- Same Day Supplements: $49.99
- Best Price Nutrition: $49.99
Interestingly, Syndrex is not for sale on Amazon, but other Metabolic Nutrition products are sold through the retailer.
There are many alternatives to Synedrex regarding weight loss products. The most commonly cited alternatives are listed here.
Lazarus Laboratories manufacture Phentramin-D. It is advertised as a fat-burner and an appetite suppressant and is rated at a pharmaceutical level.
Phen375 has been available since 2009 and is manufactured from all-natural ingredients and is backed by a money-back 30-day guarantee.
PhenQ is another all-natural diet supplement that claims to support appetite suppression, energy production, fat burning, mood improvement, and fat suppression. The product comes with a full 60-day money-back guarantee.
Phen24 is also offered as a morning and evening routine. The product comes with a full 60-day money-back guarantee.
This product is manufactured by HFL and is a medically formulated weight loss system. The product comes with a full 90-day 200% money-back guarantee.
What Users Are Saying
“Gives you burst of energy but it also includes the anxious and restless feeling that takes away your appetite.”
“Best supplement I’ve ever taken! It kept me alert and focused with a great endurance increase I can’t find anywhere else. I would definitely without a doubt recommend this product to anyone with a serious diet plan and a gym membership looking to shed the pounds. This product is not meant to be a miracle drug, everything takes a certain level of commitment.”
“Worst ever. Had me throwing up for a day straight after only one pill. Way too intense for me.”
The Bottom Line on Synedrex
So, will Synedrex help you lose weight? The business has been around for 20 years, and some dieters report positive results, but we feel uncomfortable giving our support because of the lack of clinical support. Plus, it bothers us that dieters reported side effects and a lack of results.
If the time has come to shed off the extra weight, our suggestion is to find a system that can meet your individual needs and is backed by multiple clinical studies.
Among the best programs we’ve found this year is one called Noom. Noom gives you everything you need to start making healthier choices, including human coaching, personalized meal plans, and food tracking with one of the largest databases in the world. What could get better than that?
Well, Noom is so confident in the formula they’re offering Dietspotlight readers a free trial offer, which we like.Learn More About Noom »
Rob G (Verified Purchase)
I’ve been taking it for a week now, I have no cravings at all for junk food, for the past week I eat to live , not live to eat, like I have for the past 25 years. This stuff works.
Bennie (Verified Purchase)
Just make sure to eat bout 15/30 mins before u take it, I used it for 30/45 days normal workout, the more u sweat the faster u lose it, I went from 204 to 186 n over a month, so yeah its good, but just remember everyone’s body is differant
Synedrex is an upper it can have some adverse side effects if you have high blood pressure it can be very hazardous if I remember correctly it even says so on the bottle. In my opinion no I would not take it until I talked to my dr if I was in your situation.
Amazing pills. But does it have negative sexual s
Anonymous (Verified Purchase)
Im on my second bottle and have been using Hydravax with it. I run and weight train and have noticed a VERY BIG change. I have dropped about 22 pounds from taking both of these products. I have abs and the “ripped” look. I would recommend this product to anyone, in fact I recommended it to several people I work with and they love it!
Should I be taking this if I’m 16 and an athlete. I want to lose about 15 pounds, does it sound like a good idea?
Hello. Synedrex is not intended for anyone under the age of 18, but please consult with your doctor before taking this product.
NO!!!… Learn to eat healthy and continue exercising!!! You are still young and your body is still going through changes! If you eat healthy and exercise, you will lose that 15 pounds!!! You should NOT start teaching yourself that taking diet pills is the answer!!! Make a life change with healthy eating and exercise!!!!
Cory (Verified Purchase)
This was my first day taking this . I took it on an empty stomach and within 15 min I was throwing up . That last an hour .. Had to leave work cause I was jittery and sick to my stomach, after 4 hours I was able to come back to work . I still don’t feel good I haven’t been able to eat. I am not jittery anymore just feel under the weather.. I’ml not ready to give up just yet, tomorrow I will try it with some breakfast in my stomach .
Kelly (Verified Purchase)
My pills were in a bag during travel, and some of the pills broke open and have a crack which allows me to see the powder inside that can spill out(if i tried to dump the powder out) Also, they were in the heat and some had melted a little and are softer now, is that okay to still take these pills?
Hi Kelly. It might be safer for you to just reorder a new batch just in case.
Weston (Verified Purchase)
I am 28 years old and in good athletic condition. I work out regularly and have taken a few supplements in the process to help me out. I started using Synedrex last Sunday. It was working great;it gave me plenty of energy and curbed my appetite to where I didnt even get hungry and had to force myself to eat. On the fifth day I started getting horrible nausea and tingling in my extremities especially in my hands and my heart felt like it was constantly beating out of my chest. I used the prescribed dose only one pill a day after breakfast. I never had any trouble until the fifth day. I took it the same way on the sixth and within 3 or 4 hours I was having bad side effects. My pulse was raising from low 80’s to 130’s suddenly and my blood pressure was shooting up at the same time. It would come and go. It got to where I couldn’t breathe and was unable to stand up. I even passed out a few times. I was taken to the emergency room just for to be cautious. Everything is fine now that I am off of it. It worked great in the beginning but unfortunately its not for me. So please just be careful and if you do start feeling any side effects then please stop using it. My situation could have turned out much worse had I not been around people that knew what to do.
i’m having similar effects. only i get horrible nausea, a little bit of tingling, and i get really hot and dizzy. it helps if i keep cool or get something to eat. i don’t know if its the same issue but its pretty scary.
I had the exact same side effects. I eat before I take it, and I tried taking a day off in between. I stopped taking it, my husband is taking the rest of my supply and hasn’t experienced any of those problems. I think it just isn’t for some people. I am now taking Crash also suggested by my trainer I take it before bed and it helps burn more calories when sleeping, no side effects from this one. I see this is older, did you continue taking and if so did the side effects subside?
Hi Shanna. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.
exact same reaction here..def not for me..I thought i was dying.. not worth it.
Alaynah (Verified Purchase)
I took it and wasn’t able to eat for over 24 hours without throwing
Up and woke up almost every hour when I went to bed. Total nightmare
jessenia (Verified Purchase)
I have 2 days trying synedrex n I feel horrible ….shacky and nerves, what should I do!
Ben-e (Verified Purchase)
ive been taking synedrex for a week now, i have lost over 6 pounds tho working out like crazy but i think im not shedding it fast enough do to calories low, my appetite isnt really there
cynthia (Verified Purchase)
I have been taking Synedrex for a few weeks and I have lost 8 lbs with no exercise and it does suppress your appetite.I have tried several diet pills and these work for me.
I have a comment and a question. How do you know this product has caffeine in it when it isn’t listed under any of the ingredients? How did you come about this information?
Green tea is caffeine.
LOL Green tea has “very low” amounts of caffeine. methylxanthine is caffeine pal
It has 350mg of Caffeine plus the Green Tea.
Can u take half a synedrex
Hi. For detailed product instructions please refer to the official synedrex website for more information.
I do, I just open the cap and transfer 1/2 of the contents into another capsule. one is too strong for me. still works great.
Jazzy (Verified Purchase)
Day 1, not sure if I should keep taking this pill. I am not feeling to great. I am shaky and jittery. Walked around the company like 5 times still not feeling good. Its been 5 hours and now I am nauseaed. I guess this pill is not for everyone.
Hi Jazzy. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.
I started taking Synedrex 6 days ago and I am down 7 lbs. I’ve gone to the gym 5 days out of the 6. I had severe jitters the first day but then decided to eat first the next day and try it and it made a huge difference. Protein shake with 2 boiled eggs then the pill and the jitters are gone. Hope this helps!
Yeah, if you don’t eat within 15 minutes you will get really sick. I found that a bowl of oatmeal and a pear worked great. I started this on a Wednesday and by the following Tuesday I had lost 16 lbs while doing a heavy workout ( low reps, high weight) every day. When I began to do an extensive cardio workout daily that also boosted more loss.
You have to eat something with it…not just one piece of toast. Big breakfast. Medium lunch. Light dinner.
Tony (Verified Purchase)
I am on my 3rd day using synedrex. I take these in the morning before breakfast….maybe 15mins before. The first day was really bad in the sense of jitters and a crazy caffeine overdose feeling, 2nd day better, still pretty strong, though today 6 hours after taking the tablet I feel really light headed and not as motivated as the first 2 days. I didnt have a problem sleeping the last 2 nights.
I took it this morning for the 1st time with a protizyme shake and left walking for an hour and fell great when I got back I started to feel really nautious and have spent whole day in bed, Will I feel better tomorrow?????
Hi Carmen, some dieters also experienced nausea. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.
Jill (Verified Purchase)
I went to the gym on it and I was PUMPED!! I had a great workout.
al (Verified Purchase)
i’m not the type of person to be on a bandwagon, but i been using synedrex for 2 weeks and lost ten pounds without working out looking forward to getting in the gym with it.
eddy (Verified Purchase)
hi , i am using synedrex 15 days ago , but i dont know how to finish from the side effect specially the jitters and insomnia .how can i resolve this issue . and it should be taken before breakfast or after . Thanks a lot
Hi Eddy. This is a common side effect for some dieters. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.
Actually you only take up to two a day I have been using synedrex from about 3weeks and have lost over 20 pounds I only take one pill a day and if you buy from suppliment ware house myou can get it for like 30 for a 45 days supply if you use the price compare to a sketchy website that has a rediculously low price this is my second cycle and I would suggest anyone looking to lose weight use this product also the jitters disappeared after a week or so my rating is a 5/5
Im in my third day, but i had a question. Do you have to take it everyday or just the days you go to the gym? because i was planning on taking it only on gym days…
I would take it everyday, but after two months of taking it take a month to two month break from taking it at all.
That way you keep your body guessing, but keep going to the gym regular schedule and keep your diet the same. DIET DIET DIET. It’s not just the pill doing the job for you. ITS YOU!
My trainer recommended this product to me, and it’s a great product!
I have been on Synedrex for 4 weeks now I have lost only 8 pounds. I eat less than 1,000 calories a day and I walk for about 45 minutes everyday. Other people comment that they have lost over 20 pounds – what I am doing wrong?
Hi Sue. All dieters have different weight loss results. Some users loose weight faster/slower than others.
Wow, Alan. Kinda harsh.
It is true though, eating less calories wont promote weight loss. I have been on Synedrex for 2 bottles now, with a month break in between and I have had great results. Eat well, keep walking. You need good calories, that’s it. Keep at it. It takes 4 weeks to notice a dfference in yourself, 8 weeks for your spouse to notice and 12 for your friends to notice. Keep it up!
you are not eating enough, your body is in survival mode and will not let go of fat stores.
Eat more you should be at approx 1800 calories a day.
By eating clean a proper diet will increase your metabolism. 5 meals a day. Pills will only give you a slight advantage. Keep up your workouts. Weight loss occurs over months. Don’t get discouraged.
Not enough food, too much cardio, and not enough emphasis on weight training. You need to sit with a professional to figure out your specific caloric needs as well as the proper training program for your goals. Blind caloric recommendations will not do.
I’m willing to bet that you’re not doing anything wrong and that your body and synedrex don’t cooperate with each other.
i dont think some of yall have tried using syndrex… ive been on it for about 2.5 weeks or so and have lost 15lbs. When you are taking syndrex if you eat more than 1000 calories in a day you feel bloated as crap. I usually only take in around 750 on days I take it and that includes drinking cranberry juice. Seriously, how do yall figure 45 minutes of WALKING is TOO MUCH cardio?!? I go to the gym 4 times a week, lift weights for about 1.5 hours and do 30-45 minutes of running on the eliptical. Lastly, I usually take the pill m-f and take off on the weekends and eat a nice meal on saturday and sunday. This will make you gain a couple lbs from the water your body is now retaining since syndrex eliminates water weight, also will promote speeding up metabolism. So basically I have been losing about 5-7 lbs from m-w then start to level off, gain about 2-3 lbs over the weekend, then 5-7 again m-w so avg around 3-5 loss per week. been working for me so far. ALSO note, weight loss is always going to depend on eating habits, exercise, how overweight you already are or arent. I plan on only taking until I finish the bottle to speed up weight loss to where I want to be and then just maintaining weight.