Updated: 04/18/2017 - Site operated by Leptigen
By Summer Banks Apr 04, 2017

A diet product’s worth depends on whether it helps people lose weight. Let’s find out if Synedrex works. We needed to learn as much as possible about the ingredients, side effects, and clinical support. We also took a long, hard look at customer experiences. We broke it all down and condensed it to give you the info you need.

Synedrex Readers: Click here to find out why we're giving away samples of our product, Leptigen.

What is Synedrex?

First off, Synedrex is a thermogenic supplement [1] supposedly helping to boost metabolism and burn fat. The ingredients are methylxanthine, methylpentane citrate, sulbutiamine, sandalwood extract, yohimbine, alpha lipoic acid, and poly-thyronine. The company recommends not taking more than two capsules per day. The small container means there’s no trouble taking them on the go. [2]

The company behind Synedrex, Metabolic Nutrition, started the business online in 1997. Trusted retailers and the official website sell the supplement. We like that the ingredients are available for the dieter and that we found some positive comments, but read on…

Synedrex Side Effects – “Do You Need to Worry?”

The first negative we found was with Synedrex side effects, which could be associated with methylxanthine. [3] “No dieter wants to feel shaky and jittery after taking a product,” says our Research Editor. “You can have increased energy and metabolism without the problems.”

As one dieter puts it, “The side effects while on it included excessive sweating, jitters and insomnia.”

Another user reports, even more, Synedrex side effects, ”It gave good energy, but it was too much. It made my heart feel racy.”

During our research, we did stumble on a few dieters who didn’t have the same problem. One said, “The first day I started I got incredibly hot and enough energy to last a week, had a little trouble sleeping but by day 2 that pretty much went away.” [4]

A customer shared, “I haven’t had any of the side effects listed in any of these reviews.”

Ineffective – “Frequent Complaint”

Probably one of the biggest issues with a weight-loss supplement like this is effectiveness. Clinically speaking, there are some energy boosters in there that could increase metabolism enough to affect calorie burn, but no two dieters will react the same. According to some, Synedrex ingredients do nothing to help you lose. “I didn’t lose any weight. I will look for a better fat burner,” a user reports. [5]

Another dieter with the same problem says, ”There was no change in my weight at all.”

We did read some supportive comments along the way. As one user said, “Keeps me going. Makes me sweat.”

Another commented, “I only take one pill per day, in the morning and feel it helps sustain my energy all day.”

You only need one negative, like an adverse reaction, to ruin your chance of long-term weight-loss success. In the case of Synedrex, if the side effects are as harsh as dieters report, not matter if quality research doesn’t report such issues in most participants, that’s a bad sign.

The Science – “Is There Proof?”

We visited the Science Center portion of the Metabolic Nutrition website to see if there was any support for the weight-loss product. We found articles about supplements and exercise, but no research. The most important parts are caffeine and yohimbine, [6] two stimulants. We know these ingredients boost energy and promote a stronger metabolism, but too much can do more harm than good. Based on the side effects there may be too much in Synedrex. At DietSpotlight, we need to see facts to support claims. If there’s none out there, or if the formula may cause issues, that’s not a good sign.

Also: read our Leptigen Weight-Loss Kit review »

The Bottom Line – Does Synedrex Work?

So, will Synedrex help you lose weight? The business has been around for 20 years, and some dieters do report positive results, but we feel uncomfortable giving our support because of the lack of clinical support. Plus, it bothers us that dieters reported side effects and lack of results.

If the time has come to shed off the extra weight, our suggestion is to find a supplement that contains clinically supported ingredients, with no known side effects offered at a price you can afford.

Among the best products we’ve found this year is one called Leptigen. The proprietary blend is a combination of ingredients shown in published scientific research to spur metabolism and boost fat loss. Dieter’s aren’t talking about negative side effects, and users report seeing great results.

Also, the company that makes Leptigen is so confident in the formula they’re offering a Special Trial Offer, which we like.

Previous Synedrex Review (Updated July 9, 2014):

Synedrex - What You Should Know

Synedrex is a pill form diet supplement that is advertised to help dieters shed fat and water weight by controlling food cravings. This diet pill is also supposed to give dieters an endless supply of energy, block carbohydrates and help to curb food cravings similar to GNC Burn 60. Synedrex is manufactured and marketed by the company Metabolic Nutrition. The company unfortunately has an unpleasing BBB rating. Looking at the ingredients one can see that there are some fat burners on the list; both green tea and garcinia cambogia are well known fat burners that have been shown in some studies to produce results. There does seem to be some disparity among websites that claim this product does not work as well due to insufficient amounts of these fat burners.

List of Ingredients of Synedrex

Chromium, caffeine anhydrous, green tea extract, garcinia cambogia, l-tyrosine, l-carnitine, HPMC, cocoa extract, 5-HTP, and jojoba bean.

Product Features

Synedrex is a diet pill that is advertised to give energy, block carbohydrates, raise metabolism and help dieters to lose extra pounds. Identical claims are made by Plexus Block. Dieters are instructed to take one or two capsules twice daily. On average the product carries a hefty price tag of $50 or more for a bottle of 90 capsules. If an individual two capsules twice daily as the label suggests the 90 capsules will last less than a month. The alpha lipoic acid found in Synedrex is regularly referred as an abundant antioxidant because it is both fat and water soluble, it does appear to possibly be useful for fat loss and the prevention of additional fat gain.


  • Synedrex does have added vitamins and minerals in addition to the fat burning ingredients.
  • The website has nutritional information and other diet related information as well as supplements.
  • The website also contains customer reviews and testimonials.


  • Synedrex contains copious amounts of caffeine with over 350 mg per dose. This large amount has been known to cause serious jitters, agitation and dehydration when taken over time.
  • At over $50 per bottle on average, this is one of the more expensive diet pills on the market.
  • There is no real diet plan or exercise plan included on their official site, just the pills to be taken along with a health and fitness plan of the dieter’s choosing.
  • Once dieters stop taking the pills, there is the chance that weight could return since there was not a learned modification to eating and lifestyle habits.

Conclusion on Synedrex

Synedrex does have many customer reviews and seems to help some dieters to achieve results. It is suggested, as with all diet pills, that users follow a sensible eating and exercise plan to achieve the best results. Overall this looks to be an average diet pill with a very large amount of caffeine in addition to other energy substances. Synedrex is almost like an energy drink in pill form and as such will pose the risks of the same side effects such as agitation, jitters and insomnia as well as dehydration. Read up on Synedrex Side Effects. Similar side effects are often reported with uncertain doses of stimulants like with Adaptogen or Absolute Nutrition Garcinia Cambogia. While the product may provide results it is important to remember that there are much less expensive ways to get caffeine.

Synedrex Questions & Answers:

We refined hundreds of customer comments about Synedrex into this helpful FAQ.

What are the side effects of Synedrex?

Synedrex is another pen name Synedrex goes by. Potential Syne side effects may include nausea, increased blood pressure and jitters, according to some customer reviews.

What is in Synedrex?

Synedrex ingredients are methylxanthine, sulbutiamine, sandalwood extract, yohimbine, alpha lipoic acid [1], poly-thyronine, chromium, B-vitamins, dipotassium phosphate, silicon dioxide, magnesium stearate, titanium dioxide, gelatin and FD&C blue #1 and green #40.

What are the active ingredient in Synedrex?

The active ingredient in Synedrex are methylxanthine, sulbutiamine, sandalwood extract, yohimbine, alpha lipoic acid, poly-thyronine and chromium.

Does Synedrex work?

There’s no scientific research proving the effectiveness of Synedrex. There are studies linking chromium to weight-loss, but this ingredient is common and can be found online for less than $5.

How much does a bottle of Synedrex cost?

A bottle of Synedrex costs $54.99.

What is Synedrex’s BBB rating?

The BBB rating for Metabolic Nutrition, the company behind Syne, is a concerning “C”.

How do you take Synedrex?

You take one or two Synedrex capsules per day. The website recommends not taking two pills within 15 hours of each other and not taking prior to sleep. A bottle lasts between 22 and 45 days.

Can I take Synedrex if I have a health condition?

Women who are pregnant/nursing, those taking prescriptions medications of any kind, people under 18 years of age or people with health conditions should contact a physician prior to beginning any weight-loss program or diet supplement, including Synedrex. [2]

What do users like about Synedrex?

Some users like that Synedrex increases energy above their normal levels. Customers also approve of the cost and the fact that you can use the supplement on the go.

What do users NOT like about Syne?

Dieters do not like the idea of side effects with a Synedrex. There are also comments about poor customer service quality and short 30-day return policy.

Who makes Synedrex?

Metabolic Nutrition makes Synedrex.

How do I contact the Synedrex customer service department?

You can contact the Synedrex customer service department by calling 1-954-533-9256, using the customer feedback form on the official website or sending correspondence to Metabolic Nutrition 10318 NW 55th St Sunrise, FL, 33351.

Can I contact Synedrex through social media?

Yes, you can contact Syne through Facebook and Twitter.

Is Synedrex for men and women?

Both men and women can use Synedrex. The ingredients don’t address specific gender needs.

Do you need to “cycle” off of Synedrex?

You don’t need to “cycle” off of Synedrex. The website recommends stopping use for two weeks after using it for 12 weeks, however.

Do I need to exercise with Synedrex?

You don’t need to exercise with Synedrex, but the company states optimal results occur when you combine with diet and a fitness plan.

Is there a guarantee with Synedrex?

Synedrex offers a 30-day money-back guarantee.

When taking a closer look at weight loss supplements that work best for health and fitness, Leptigen came across as a noticeable product with four ingredients clinically shown to boost energy levels and help the metabolism run at a faster pace, resulting in weight loss.


Synedrex User Tips:

7 Top User Tips

Over the years, we’ve seen that Synedrex users have a lot to say. After analyzing thousands of comments and reviews, these are the tips we think will best prepare you to try this product.
“One piece of advice…try to eat something and drink water because you will get nauseated.” James


“I take it first thing when I get up in the morning around 5:30am and I’m still having some issues staying asleep at night. So when they say take it at least 12 hours prior to bedtime they mean it.” Jennifer


“You do need to push your fluids because it will even push you away from drinking anything too.” Mike


“Whenever I do take a pill I try to take it 20-30 minutes before my work out because that is usually how long it takes to fully kick in, the energy boost is outstanding” Maria


“If you’re sensitive to stimulants and want to try this product I suggest you take it very very early in the morning and with food. Wait at least thirty minutes before you work out.” Angie


“ To lose the weight I have you need a total plan, including healthy eating habits, consistence in workouts, not just a magical pill. Michael


“This product is strong, really strong. I have a real high tolerance for caffeine and could not drink coffee after taking this for about 3 hours.” Debbie

Synedrex Scientific Abstracts:


Testing of the thermogenic reaction of 22mg ephedrine, 30mg caffeine, and 50mg theophylline was studied within human participants with a proclivity to obesity. It was found that the ephedrine/methylxanthines combination were two times as effective as the ephedrine by itself, raising the fasting metabolic rate in all participant groups. It normalized the decreased thermogenic response to a 1.25-MJ meal in participants who were predisposed to obesity. The studies had suggested that small doses of methylxanthines, when combined with ephedrine, could increase the daily energy expenditure of obese participants, largely by fixing their poor thermogenic food response. It had been concluded that ephedrine/methylxanthine could very well be a useful tool in the treatment of obesity. [1]


30 participants with diabetic polyneuropathy were recruited for this study. They were assigned sulbutiamine or no treatment to test the effects on glycemic control, the severity of neuropathy and electrophysiological parameters at the start of the trial and after the six week period. No substantial improvement in symptom scores was noticed in the groups. However, a significant increase in comparison to the baseline was witnessed in the sulbutiamine group (p< 0.05). Glycemic control in all participants didn’t change and remained consistent throughout the study. The sulbutiamine improved peripheral nerve function in diabetic polyneuropathy, but symptom scores remained the same due to the shortened length of the study. [2]


Human bladder cancer cells showed a more sanative pro- apoptotic effect to frankincense. Sandalwood oil displayed similar potency when it came to suppressing viability of both UROtsa and J82 cells. Even though both oils had activated similar pathways like inflammatory interleukins (IL-6 signaling), they each had a unique molecular action on bladder cancer cells. The negative regulation of protein kinase activity, as well as G protein-coupled receptors, had been activated by sandalwood oil. In conclusion, sandalwood essential oils had different mechanisms than frankincense. However, both leading to the death of cancer cells.[3]


There had been no remarkable differences in body mass and muscle mass in trials (p > 0.05) following supplementation protocol. The percentage of body fat greatly reduced in the yohimbine participants after protocol (9.3 +/- 1.1 vs. 7.1 +/- 2.2%; p < 0.05). Also, the fat mass had been significantly reduced in the yohimbine as opposed to the placebo group (7.1 +/- 2.2 vs. 9.2 +/- 1.9%; p < 0.05). There were no differences in exercise (bench press, leg press, vertical jump, shuttle run, power test results, and dribble) during trials (p > 0.05). No participants had reported adverse side effects from the yohimbine. The conclusion is that yohimbine supplementation mixed with resistance training doesn’t substantially change body mass or muscle mass or performance indicators. It was found that yohimbine seems to be a useful way for athletes to lose fat. [4]

Synedrex Side Effects:

In the world of weight-loss supplements, even natural solutions may not be completely free of side effects. It’s possible to experience a negative reaction to any type of formula. Though Synedrex side effects don’t happen in all users, they do exist for some.


When you feel unsteady, weak, woozy or even faint, it may be a dizzy spell. Dizziness might also be called vertigo and makes it seem like the things surrounding you are spinning.

What causes dizziness?

Dizziness is a symptom of many health issues and a side effect of some medications and supplements. It may be cause by simply standing too fast or something much more serious. Many people associate dizziness with overconsumption of alcohol, migraine headaches and specific medications.

Racing Heart Rate

If your heart feels like it may explode out of your chest or it’s beating very fast, it’s a racing heart rate. This is also known as tachycardia. While a racing heart rate isn’t always serious, sometimes it can be a problem requiring medical attention.

What causes a racing heart rate?

A racing heart rate may be caused by a serious heart condition, poor blood supply to the heart or even emotional stress. It may be a sign of an infection or a heart valve problem. It may also be caused by drug or alcohol abuse or even over use of caffeine. [1]


A discomfort felt in the abdomen making you feel like you may vomit is known as nausea. It’s a queasy feeling and causes a large amount of discomfort.

What causes nausea?

Nausea may be caused by many different things from something you’ve ingested to a physical injury or even from many different diseases. [2] Medications and supplements may cause nausea if your body is having a negative reaction. It may also be caused by head injuries, such as a concussion.


The jitters are an uneasy feeling of nervousness or irregular movement. You may feel very unsteady or incredibly anxious.

What causes the jitters?

While the jitters may be caused by anxiety or stress, they may also be caused by ingesting too much caffeine. Certain medications and supplements may also cause the jitters.

Synedrex side effects are not common in all users, but some have reported dizziness, a racing heart rate, nausea and jitters, among others. Make sure you protect yourself by consulting with your doctor before taking any weight-loss supplement, especially if you’re pregnant, nursing, suffer from a medical condition, are taking prescription medication or you’re under 18 years of age.



Syndrex is a thermogenic that’s supposed to increase heat production and thus boost weight-loss. Though side effects aren’t shown to happen often, these are what some users have experienced.


“I was already feeling horrible heat flashes to cold flashes to dizziness and spinning like being drunk and jittery to a sickening point…I went home and by 3 in the afternoon I was puking.”    Sarah


“I have had a dull headache, I feel off balance,i dont feel like my mind is clear, it’s crazy.”    Pamala


“My heart pounds like crazy even pulsates hard in my neck. I’ve vomited. I’ve had diarrhea.”    Dawn


“I felt nausea, jitters, sweats, chills and threw up and couldn’t settle down all day and night…I felt heart palpitations and increased blood pressure and I didn’t even exercise! I didn’t have an appetite because I was so nauseous.”    Andrea


“Horrible jitters, and for hours I had severe nausea. The only reason I didn’t vomit was because I didn’t eat anything and stayed very still while taking deep breaths when the urge would hit me. No sleep last night, despite bedtime being 12 hours after I took the ONE pill. Now, the next day, I’m still jittery.”    Jennifer


“…I started to vomit like there’s no tomorrow…in less than 3 hours of me taking the pill. My heart is pumping so fast I am having hard time breathing.”    Kathy


“…before even beginning my workout routine, my heart rate spiked from a resting rate of 60bpm to 205bpm in about 30 seconds. It lasted for about 30 minutes, before it slowed back to 60bpm.”    Mike


“I became dizzy unable to breathe normally my heart was beating so fast it didn’t feel like it was beating at all!! I was sweaty then hot and all my extremities were cold clammy and I felt very panicky.”    Shelley


“I became dizzy unable to breathe normally my heart was beating so fast it didn’t feel like it was beating at all!! I was sweaty then hot and all my extremities were cold clammy and I felt very panicky.”    Maria


“…the first day I had no appetite just tons of energy. The second day I was nauseated all day…After 7 days I couldn’t take the nausea anymore so I quit taking them. I was constantly nauseated for an entire week without the pills”    Corrina


Looking for a supplement that doesn’t give you irritating side effects? We have one you may want to check out. Leptigen is made with clinically tested ingredients and supported by users reviews that consistently report weight-loss.

There comes a time when a supplement deserves a bit more attention, like Synedrex, so we’ll concentrate on Synedrex side effects. Further consideration will be given to ingredients and clinical research. We’ll also analyze hundreds of consumer comments. Afterwards, we’ll summarize the info to give you the bottom line.

What You Need to Know

To start, Synedrex is a fat burner containing caffeine, sulbutiamine, yohimbe extract, methylxanthine, sandalwood extract, alpha lipoic acid, poly-thyronine and B-vitamins, among others. The recommended serving is one capsule per day, which supposedly results in increased weight-loss. One of the benefits is ease of use.

The product, introduced as a fat burner by Metabolic Nutrition more than 25 years ago, appears to include some natural ingredients, a good start. You can shop for Synedrex on the official website and through online retailers. We like that the company has a strong position in the market and that we located some positive customer comments, but read on…

Skin Irritability

The first issue with Synedrex side effects is skin irritability. “One of the main purposes of weight-loss is to love the skin you’re in,” said our Research Editor. “If a supplement like Synedrex leaves you irritated, that may be a sign to try another product.”

“I took it and within 30 min. I felt like my face was on fire…then that sensation spread to my arms then my stomach. When I looked in the mirror after I felt my lips tingling I seen I started breaking out in hives,” commented a dieter.

“I took 1 pill of Synedrex yesterday at 1:30 pm and 30 minutes later I felt hot all over. I had tremors and I couldn’t really focus,” said a user.

Increased Heart Rate – “Yikes!”

Based on customer comments, Synedrex side effects include increased heart rate. “I became dizzy unable to breathe normally my heart was beating so fast it didn’t feel like it was beating at all!! I was sweaty then hot and all my extremities were cold clammy and I felt very panicky,” commented a user.

“I recently started taking these pills and now I’m going to stop. I started feeling very faint, dizzy, sweaty and nauseous, all of the symptoms that EVEN the label on the bottle tell you can happen. Happened to me,” reported a customer.

“It gives you an intense level of energy, but at the cost of jittery, shaky, anxiety filled days with a heart that feels like it’s going to give out. I’ve taken it 6 days a week for 6 weeks, but I’ve been forced to quit due to the compounded side effects, and the different ones that start appearing the more you take them. Headaches, nausea, insomnia,” said a consumer.

Throughout our extensive research of supplements, we’ve found that something small, like increased heart rate, could reduce the chances of long-term success. If Synedrex causes negative reactions of any kind, there’s a concern [1].

The Science

According to the Synedrex website, the formula in the supplement is scientifically engineered, meaning the product is supposedly linked to clinical research. After a bit more investigation, we couldn’t locate studies supporting the claims. What we did find was information on sulbutiamine, an ingredient in Synedrex. According to the National Institutes of Health, side effects may include headache, constipation, dry mouth, back pain, nervousness and difficulty falling asleep, among others. At DietSpotlight, finding evidence a weight-loss product works is critical. If a company can’t provide all of the details, we have to walk away.

The Bottom Line

After taking a close look at Synedrex, here’s our decision. We like that the company has been in business for decades and that we found some positive customer comments, but we can’t recommend it because there’s no published clinical research supporting weight-loss claims [2 ]. Plus, we’re also concerned that increased heart rate and skin irritability could cause bigger concerns [3].

If you’d like to lose those extra pounds, we recommend going with a supplement supported by published clinical research, with no one reporting negative side effects [4].

Leptigen is one of the best supplements we’ve researched in 2016. The product contains a formula consisting of a four-ingredient proprietary blend, which has been shown in published scientific studies to help dieters increase metabolism and ignite fat loss [567 , 8]. No one is reporting negative side effects and comments on the web highlight dieters seeing exceptional results.

The company that makes Leptigen is so confident in the supplement, they’re providing a Special Trial Offer, an excellent choice.

Synedrex is a "Powerful Stimulant" that claims it can boost metabolism, cut fat and even smooth out lines. There is a Science Center, but we didn't find any compelling science or research of any kind. The fact that caffeine is a big part of the formula is clear, but you're not told just how much is included.

Synedrex Ingredients and Supplement Facts

Serving Size: 1 Capsule
Serving Per Container: 45
Amount per Serving % DV
Proprietary Blend 920mg *
- Methylxanthine * *
- Methylpentane Citrate * *
- Sulbutiamine * *
- Sandalwood Extract * *
- Yohimbine Extract * *
- Alpha Lipoic Acid * *
- Poly-Thyronine * *

Other Ingredients: Dipotassium phosphate, microcrystalline methyl cellulose, silicone dioxide, magnesium stearate, titanium dioxide, gelatin

We researched Synedrex ingredients in order to give you the information you need.


Methylxanthine, also known as xanthine, is a chemical found naturally in body tissues and fluids.

What Is It Supposed To Do?

The main purpose of methylxanthine is increasing alertness in the nervous system, although it may also help asthma.

Clinical Research

According to a study published in Canadian Journal of Applied Physiology, “The effects of ephedrine, in conjunction with methylxanthines and aspirin, in humans appear unequivocal but include various cardiovascular side effects. None of these compounds have been tested for their effectiveness or safety over prolonged periods of time.” [1]

You may want to try Leptigen, which has clinically tested ingredients.


Sulbutiamine is a chemical containing two thiamine molecules. It is thought to be found in the brain.

What Is It Supposed To Do?

Not to be confused with sibutramine, an appetite suppressant, sulbutiamine is a compound used for memory, fatigue, and the health of the nervous system.

Clinical Research

According to information published by the American Society of Health System Pharmacists, “Although thiamine has not been shown by well-controlled trials to have any therapeutic value, the drug has been used for the management of poor appetite, ulcerative colitis, chronic diarrhea, other GI disorders, and the cerebella syndrome.” [2]

Sandalwood Extract

Also known as East Indian sandalwood, the sandalwood tree, where the sandalwood extract is derived from, is not easy to grow due to the specific conditions it needs for proper cultivation.

What Is It Supposed To Do?

Sandalwood extract is used traditionally for aromatherapy, spiritual use, and commercially for perfumes.

Clinical Research

In a study published Phytotherapy Research, researchers concluded about sandalwood extract that, “However, until further studies are conducted to determine safety regarding internal use, this herb warrants caution with use.”


Yohimbe is a tree found in Africa. The bark is used to make medicines.

What Is It Supposed To Do?

Yohimbe has been used for a wide variety of treatment, including erectile dysfunction, depression, athletic performance, weight-loss, high blood pressure, and much more.

Clinical Research

In a study published in Research in Sports Medicine, researchers studied the effects of yohimbe on athletes. In conclusion, “Nonetheless, yohimbine supplementation appears to be suitable as a fat loss strategy in elite athletes.” This does not hold promising results for those who are not at this level of exercise.

Is There Anything Out There That TRULY Works?

Before you give up on weight-loss, we suggest you try the Special Trial Offer from Leptigen. They have clinically-tested ingredients and consistently positive customer reviews. Click here to try out the supplement.

Get Your Sample Today »
Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Leptigen, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 3.6. From 406 votes.
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User Comments

267 Comments on "Synedrex Review"


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Cody Poplawski

Synedrex is a strong supplement to get use to. At first you feel a flu like symptom. Cold, jitters, loss of sleep, hairs stand all over your body, you are extremely spaced out or in depending on how you look at it. It makes you feel sick for the first couple days, just like everything else that you do for the first time. Smoke weed… first time you get sick. Drink booze… sick. Take a synedrex… sick! After about 2 days you start to get use to the product and it works as specified online. I have burned 15lbs in 2 weeks. Although I am in the gym 4 days a week and the pill suppresses your hunger. Protein drink in the morning for breakfast with your pills… (synedrex, thistle, fish oil, etc…) Oatmeal for lunch, chicken fish or steak for dinner maybe… 6oz and sides if I can eat them. Eat your protein first. Followed by vegis then everything else. DRINK A LOT OF WATER! A gallon throuout the day. If you drink water to fast it can be very deadly. Different story… look into it. If you have concerns let me know.


I just bought the product and I am very excited. I want to ask if the dosage should vary according to the current weight and weight goal.
I am 22 and I am 58 kgs, aiming to lose an average of 8kgs. Is the recommended dosage in the package good for me ?

Hi! For detailed product and usage instructions, please refer to the Synedrex official website for more information.

detox program

Very good material compared to most of the other topics I’ve discovered. Continue the good work.


How can i buy synedrex from your site


Hi Mohammad! You will need to refer to the Synedrex official website for more information to purchase this product.


It’s my 2nd day trying synedrex. I haven’t weighed myself but I feel thinner. The side effects are unbearable. I ate breakfast with the pills & drank plenty of water. As far as appetite suppressant, it’s not that strong. I can’t take it, I can’t focus, I feel so jittery & I’m holding back from throwing up. I ran 2 miles to try & burn off the energy & still felt sick to my stomach. After trying to rest 4 hours after taking it, I still feel sick & I’m having sharp pricking pain in my chest. This product is not for me!


I was taking this product, the first day I felt like I was coming down with the flu. I was sweating with goose bumps and chills, I felt like I was going to vomit and I was shaking. I figured it would go away after a few days, I took the product for a week and each day felt the exact same. I had no issues sleeping and the effects wore off by 3 or 4 in the afternoon. I still have a large amount of the product sitting in my cabinet, could not return it, paid for it… looking for something else now.


Can you split the pill in half at first? is it powder in a capsule?


Hi! For detailed product and usage instructions, please refer to the Synedrex official website for more information.


so i just start today. Im cold. Not feeling hungry. Lets see how its works all the week. Just a question. I have to lose 40 pounds so i feel heavy and lazy. I dont do exercise its ok to take this pill without excersice?????

Hello. All users are different and can experience different weight-loss results, but exercise in conjunction with a healthy diet and supplements have shown to help with weight-loss.


second day! Im not hungry but i dont feel like yesterday that i wont eat at all. Well after 3rd day i have to take two pills lets see how work. I didnt weight my self but prob tomorrow i will because i need to know. This is my last option about pills


Hey so I’m just thinking of taking this. I also currently on Animal Pak. Wondering if it would be a little too much ? Also any recommendation by anyone of which protein to use with this in combo ? Thanks LMK

Hi! Because of possible interactions with other products, please make sure to consult with your physician before starting to take this product.


I have a question will this show up on a sports physical? I’ve taken this since February and i feel great and it’s working, but i get all the side-effects that everyone is talking about. I’ve been able to adjust, but I feel like my body has grown more “numb”. Is that normal? Will this have long-term effects on me if i keep taking it?

Candace (Editor)

Fortunately, Catherine, this product doesn’t contain ingredient that could test a false positive. As for the numbness, we urge you to seek out your doctor’s counsel; they know your body better. In the mean time try taking a break from this product.


I jus bought it yesterday and my question is do i havr to take this before breakfast or after breakfast? And again am eating jus vegetables as my diet, is it okay or i can eat anything? Thank you

Cameron (Editor)

You can take up to two capsules a day, though you may want to start with one according to the directions before breakfast. A vegetable based diet is good but may be hard to stick to. Try to switch it up.


I have a question.. I have been drinking a pre work out. E. S. P. Do I need to quit drinking that while taking SYNEDREX?

Cameron (Editor)

There should not be a conflict between the two, but ask your doctor before taking.

Your Namelaura

I tried synedrex twice!!! And both times worked for mesmile


I started this week on Monday…I felt awful all day and had trouble going to sleep. It suppressed my appetite but that is because I felt as though I was on the verge of vomiting all day. I skipped the second day so today is my 3rd day and 2nd pill and I feel terrible again. I have been feeling sick to my stomach all day. I like that my appetite is suppressed, but I DO NOT like feeling sick all day. This feeling is terrible and I am not sure if it is worth it. My friend is taking these and she gave me 4 to try and see how I do on them…I do not think I am going to purchase a bottle because the side effects are to much for me. My friend said she felt bad but started feeling better after day 5, but I do not want to suffer for 3 more days feeling like this. I will have to try something else.


I got all side effects of it, I recommend you trying only half dose a day. It really worked for me, it does the job and almost no symptoms at all. Also I readed in this page to eat dry toast, believe me it works. I now having a dry toast with cream cheese every morning before medication and more problems. Good luck!!


It made me feel that same way at first. After I tried “sandwiching” it between food. (Eating a little, taking the supplement, and then eating a little more) The stomach ache went away!


I’m fascinated by the comments that I read though the effects are real, I sampled to try to find a solution. First of all this product although a weight loss supplement, isn’t designed for those who don’t exert themselves in the gym, no consume a greater amount of water, who may have a weak heart, high blood pressure, diabetes etc. Here’s the solution to the side effects. #1. I purposefully took 2 pills to see the results and yes every side effect was absolutely present. So if this is the effect of taking too much for my body mass and health condition then number 2 should be your choice. #2 I had taken 1 pill for one entire week with zero side effects drinking a decent amount of water and a bite of food. I had an unheard amount of energy that I appreciated very much. So to the solution, #3. Take one half of the daily recommended amount to see what your effects are if any and then begin to modify or increase to a full pill. I will confess that one of the great results was that I spend 3 hours Monday-Friday in the gym so my body was used to working out. All this amazing product has done with the proper dose, has enhanced my overall gym experience to the maximum!


Shannon.. you are correct , I felt the same way as I was reading the post.. never tried 2 pills a day because 1 pill did what I needed it to. I work out in the early morning so I never felt not being able to sleep. It was perfect for what I needed.. but each person is different in there workouts and the time the pill is taken


Ok so I’m sure I’m not the only oerson having penile problems with this product. The negative, it’s hard to stay erect. It seems to effect my testicles either enlarging one or shrinking the sack to the point of where my testicles move around which is weird and painful. Burning urination that can make you feel like you have an std…….. Maybe it’s an allergic reaction to me. I’m not being oerverted or funny. This has happened both times I used it. I wish the original oxyelite was still being made. If you have any questions or you can relate feel free to email me

Hi Joey. Please consult with your physician if you continue to have these side effects to make sure this product is safe for you to take.

Your Name

Take one with a tall glass of water. Wait 30mins-1hr to eat becuase the pill will act as a laxative. Avoid any other caffeine drink for a few hours

Your Name

With a large glass of water. Wait an 30mins-1hr to eat becuase it can act as a laxative. Avoid any other caffeine drink for a few hours.


Ive been taking these for a year now on and off. They are wonderful but they are very strong. They come in a case that allows you to dump some out which Is what I would do your first time. Dump about a quarter until your body gets used to it. These aren’t for everyone especially if you have a weak stomach. But they do work. I haven’t been exercising so ive only lost about 15 pounds on and off. But they DO CURB HUNGER like a beast. They do make you jittery and sweaty because its speeding up your metabolism. I know when I first started taking them I couldn’t sleep because I was wired but im used to it now. Im actually going to start using both this product and their phenolox product together. Don’t be scared they do work just very strong! you are welcome!

Your Name

I buy empty capsules and divide them up into quarters. Don’t just dump and waste it.


Are the ones on ebay?

Your name

I have 1 question can I take it wothout going to gym cuz I cant go to gym for 3 months I have alot of exams in college but I can do cardio at home but still should I take it in the morning or before I start cardio ?

Stephen (Editor)

Hi! You may want to combine this with a proven fat burner. Of course be sure to ask your doctor before using any supplement.