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Synedrex Review - 13 Things You Need to Know

With only one pill a day, Synedrex claims it can help you increase energy levels and the metabolic rate. The pill claims to be “the most powerful thermogenic agent on the market.” Upon further research into their ingredient list, including bitter orange and hordenine, it is clear that science may not back these claims.

Our research team looked into their “scientifically researched and proven ingredients,” product warnings, and the discounts available online and in-store to learn more about this diet pill. In the end, we compared the ingredient research on Jarensis extract and Yohimbe to the customer reviews on the Metabolic Nutrition official website to see if this is worth the money.

Synedrex can be purchased through their Official Site.

Synedrex Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

Synedrex Video Review


What is Synedrex?

Synedrex pills are marketed as a thermogenic supplement designed to burn fat and boost your metabolism to reduce weight and inches.

Synedrex pills are sold via the web both from the manufacturer’s website and several other online retail sites, and this is what the research has to say about the ingredients:


Synedrex Competitors

Other similar products: , , OxyELITE Pro,

How Did Synedrex Start?

There is no information available as to when Synedrex was first marketed.

Synedrex original was manufactured with the, now banned, chemical DMAA. This formulation was withdrawn with the banning of DMAA, and Synedrex’s new formula was brought onto the market.

The manufacturer is Metabolic Nutrition Inc, based in Tamarac, Florida. The company manufactures and sells a range of nutritional supplements that include weight loss supplements, vitamins, and other health and muscle mass supplements.


Synedrex Claims

The manufacturer claims that Synedrex weight loss pills have been scientifically engineered to ensure that all the ingredients work synergistically to ensure that the user maintains their energy levels and avoids the energy slump common with the use of products that contain powerful stimulants.

The manufacturer claims that Synedrex weight loss is possible. Still, the product will energize you, suppress your appetite, accelerate your weight loss, enhance your mental clarity and concentration, and improve your mood.

The manufacturer also claims to use ingredients that are scientifically researched and proven in this product.

Synedrex claims

When looking at the weight loss section, a similar set of blog-style articles was found but no scientific research.

The articles listed are not current, and this site is infrequently updated. The latest four articles are dated April 2016, October 2016, and December 2016.

Metabolic Nutrition also touts the Thyrene and Synedrex stack to boost your weight loss regime.

The claim is that the consumer “will lose weight with the Synedrex weight loss pills, but by taking Thyrene at the same time, you will improve your thyroid function, which will aid in boosting your metabolism.”

Thyrene is not a stimulant, so, according to the manufacturer.


Synedrex Ingredients

The Synedrex weight loss pill claims to be a successful weight and inch loss formulation. The Synedrex ingredients in this product are:

  • Caffeine Anhydrous
  • Eria Jarensis Extract
  • Grains of Paradise
  • Bitter Orange
  • Yohimbine HCL
  • Higenamine
  • Hordenine
  • Huperzine A
  • Naringin
  • N-Methylphenethylamine
  • L-Dopa
  • Poly-Thyronine

Additional Information on the Ingredients

Caffeine Anhydrous

Anhydrous caffeine is nothing more than dried caffeine available in a powder form that has many uses.

Caffeine is listed as a nervous system stimulant and is defined as being a substance that will be habit-forming rather than one that is addictive, according to the journal Brain Research Reviews

The problems arise when someone that regularly takes large intakes of caffeine stops; they may be subject to withdrawal symptoms such as nausea, headaches, and fatigue.

The International Society of Sports Nutrition claims that caffeine is beneficial for athletes engaged in extended exercise (endurance races) and high-intensity exercise (rugby or football) rather than strength exercises such as weightlifting.

Synedrex has up to 650mg of caffeine in one capsule, though the exact amount is unknown because it is contained in a proprietary blend..

To give some idea of how high this is, a coffee cup will contain between 50 and 475mg dependent on the brewing process, while cola drinks have 0 to 115mg per 12oz serving.

Eria Jarensis Extract

The Eria Jarensis extract comes from the Eria Jarensis orchid and is also known as N-Phenethyl Dimethylamine or N, N-Dimethylphenethylamine.

This is another stimulant gaining popularity as a replacement for banned substances such as ephedrine, DMAA, and AMP-Citrate.

Grains Of Paradise (Paradoxine)

Grains of Paradise comes from the fruit and seeds of the Aframomum melegueta plant.

There are very few studies that show what this herb does. Some preliminary work on the herb has indicated that it may stimulate the brown adipose tissue, leading to weight loss, but this study has only been done in rats.

Another study completed on rats has some inconclusive findings showing that this may have weight reduction possibilities, according to Autonomic Neuroscience, but the results must be replicated in human studies.

Synedrex ingredients

Bitter Orange Extract

Bitter Orange (Citrus Aurantium) is also known as Seville Orange, Or Sour Orange, and comes from a tree native to the Mediterranean, but it is now grown worldwide. Its medicinal properties have been known for centuries, and it was originally used for constipation, cramps, and stomach pain.

In more recent years, it has gained popularity as a weight-loss supplement, and though there is some scientific support for its effectiveness in weight loss, there is debate over its safety.

This debate revolves around the alkaloid synephrine, which has a similar molecular structure to ephedra, a drug banned by the Food and Drug Administration.

According to the University of Michigan Medicine, there is insufficient data to establish clearly whether or not Bitter Orange will have the same effect as ephedra at this time.

Yohimbine HCI

Yohimbine HCI is a chemical extracted from the bark of the Yohimbine tree native to West Africa. The chemical has been traditionally used to manage erectile dysfunction in men as it enhances the blood flow to the genital area.

Its effectiveness in weight loss stems from some preliminary work done that shows that ingesting this chemical before exercise, specifical soccer in this study, may increase the possibility of stubborn fat deposits being broken down, according to Research in Sports Medicine.

Higenamine (Norcoclaurine)

Higenamine is a chemical extracted from plants such as nandina bamboo, Chinese aconite, and Lamarck’s Bedstraw. Its use is associated with being a fat burner.

Other ingredients include Hordenine, Huperzine A, Naringin, N-Methylphenethylamine, L-Dopa (stand 99%), and Poly-Thyronine.

Does Synedrex Work?

Synedrex reviews for this product are mixed, and as they are all based on anecdotal evidence, it is difficult to determine whether the product works or not. The scientific pages on the website are all blog-type pages and give no links to any scientific research. There are means of contacting a scientist directly by filling in an inquiry form on the web, but there is no indication of the scientist that will answer the question and whether they are qualified or not.

As stated, there are some positive Synedrex reviews for this product. Still, some of the individual ingredients are powerful stimulants and many customers reported unpleasant side effects after taking the product.

The Synedrex fat burner has received some positive reviews on the net, but as has been previously stated, there is no proof that the product burned the fat or if it was a simple change in lifestyle that was responsible for the change.

Some of the individual ingredients have been the subject of alternative tests. For example, Bitter Orange was the subject of a project documented in Current Therapeutic Research.

Does Synedrex work

In this project, a group of test subjects was given a combination of caffeine, bitter orange, and St. John’s Wort while a control group was given a placebo. The combination pill group was found to have lost a significant amount of weight during the six-week study.

Synedrex bodybuilding is advocated on some forums for use in the bodybuilding arena. The claim is that the product’s energizing effect will assist with the rigorous exercise routines that bodybuilders undertake.

Perhaps the best place to start would be to use one of the Synedrex coupons that are available via websites such as Couponsock and Dontpayfull.

Taking advantage of Synedrex coupons will allow you to purchase the product at a reduced price and see if the product suits your requirements or not before paying the full price. Another option along the same lines is to look for advertised free Synedrex samples.

These Synedrex samples will allow you to try a small amount of the product and again, decide if you like them or not.

Details On Synedrex And Weight Loss

The Synedrex weight loss pill is a capsule that should be taken in the morning.

No two people will react the same way to any compound, so the expected increase in your metabolic rate and the fat that you should burn may or may not happen depending on your circumstances. Many reviewers claimed to have lost no weight while using the product but others claim to have lost weight.

Those who lost weight did not give details about whether they had adjusted their diet and exercise routines while taking Synedrex weight loss pills, so there is no proof that the product was the reason for the lost weight or altered diet and exercise programs contributed to the weight loss.

The company website does have many articles on how to exercise and follow a healthy diet, so it is likely that if customers follow the suggested eating and exercise plans, they could lose weight.


How To Use (Take) Synedrex

The Metabolic Nutrition website advises that Synedrex is a strong compound and that consumers should take one capsule a day in the morning along with your breakfast. They advise that the capsule should not be taken within 12 hours of your normal bedtime as it may interfere with your sleep.

The website also advises that you drink plenty of water during the day, and one of the common complaints about this capsule was that consumers suffered from feeling thirsty all day.

Metabolic Nutrition also advises that it is good practice to stop using the product every eight to twelve weeks to allow “the body to reset itself.”

Metabolic Nutrition claims that Synedrex weight loss pills can be taken in conjunction with other Metabolic Nutrition products but advise against taking it with any other company’s product.

The website states that this product is not suitable for pregnant women, lactating mothers, prepubescent children, or anyone who suffers from a pre-existing health condition affected by a high stimulant product.

Synedrex should not be taken with any other weight loss supplements.

Synedrex side effects

Side Effects

Potential Synedrex Side Effects

Many reviews on the web indicate that there is a possibility of serious side effects when taking this product.

The reported side effects that can be attributed to some of the ingredients include:

  • Nausea
  • Sleeping issues
  • Dehydration
  • Headaches
  • Jitteriness
  • Elevated heart rate


Caffeine is a stimulant for the central nervous system and is in the same class as a methylxanthine. Too much caffeine can lead to jitteriness, a feeling of being shaky on the legs, excessive sweating, and sleeping issues. It can also lead to an increased heart rate.


Children are known to be very sensitive to yohimbine. If you are taking any medications, do not take yohimbine as it can increase the side effects.

FD&C Blue 1 and FD&C Red 40

These are two food colorants, and both have been the subject of warning notices.

Product Warnings

Synedrex Product Warnings

The Synedrex label warns:

  • Not to exceed the stated daily dose
  • Not suitable for pregnant or lactating mothers
  • Not suitable for anyone under the age of 18
  • Not to be taken in conjunction with alcohol or caffeine

Any Synedrex Lawsuits?

According to Top Class Actions, Syndrex was named in a class-action lawsuit in 2017. The lawsuit alleged that Metabolic Nutrition knowingly added an illegal ingredient, methylpentane citrate, to the formula. We didn’t find the ingredient listed on the label as of early 2019.

Synedrex alternatives

Where Can You Buy Syndrex and How Much?

You can purchase Synedrex on the Metabolic Nutrition website and other supplements and general retail locations.

  • Metabolic Nutrition: $49.99
  • Walmart (45 capsules): $33.90
  • Same Day Supplements: $49.99
  • Best Price Nutrition: $49.99

Interestingly, Syndrex is not for sale on Amazon, but other Metabolic Nutrition products are sold through the retailer.

Synedrex Alternatives

There are many alternatives to Synedrex regarding weight loss products. The most commonly cited alternatives are listed here.


Lazarus Laboratories manufacture Phentramin-D. It is advertised as a fat-burner and an appetite suppressant and is rated at a pharmaceutical level.


Phen375 has been available since 2009 and is manufactured from all-natural ingredients and is backed by a money-back 30-day guarantee.


PhenQ is another all-natural diet supplement that claims to support appetite suppression, energy production, fat burning, mood improvement, and fat suppression. The product comes with a full 60-day money-back guarantee.


Phen24 is also offered as a morning and evening routine. The product comes with a full 60-day money-back guarantee.

Lean Optimizer

This product is manufactured by HFL and is a medically formulated weight loss system. The product comes with a full 90-day 200% money-back guarantee.

What Users Are Saying

What Users Are Saying

“A++++ The best fat burner on the market by far! Lost 40 lbs in a little less than 4 months. Curbs appetite and gives energy without the jitters!”

“Damaging I was recommended this product to help me tighten up my stomach. The first time I took this product for 8 hrs my stomach was hurting and I felt nauseous. My body felt weak and I had a headache. I figured it’s because I took it on an empty stomach. Today I tried it on a full stomach and it still made my stomach hurt and now I’m having chest pains too. At the store the worker told me a lot of people said they don’t like it because it made them feel nauseous too.”

“I’ve enjoyed this energy boosting product for over 3 years. The price has been good and mainly it works.”

Bottom Line

The Bottom Line on Synedrex

So, will Synedrex help you lose weight? The business has been around for 20 years, and some dieters report positive results, but we feel uncomfortable giving our support because of the lack of clinical support. Plus, it bothers us that dieters reported side effects and a lack of results.

If the time has come to shed off the extra weight, our suggestion is to find a system that can meet your individual needs and is backed by multiple clinical studies.

Among the best programs we’ve found this year is one called Noom. Noom gives you everything you need to start making healthier choices, including human coaching, personalized meal plans, and food tracking with one of the largest databases in the world. What could get better than that?

Well, Noom is so confident in the formula they’re offering Dietspotlight readers a free trial offer, which we like.

Learn More About Noom »
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What are the side effects of Synedrex?

Synedrex is another pen name Synedrex goes by. Potential Syne side effects may include nausea, increased blood pressure and jitters, according to some customer reviews.

What is in Synedrex?

Synedrex ingredients are methylxanthine, sulbutiamine, sandalwood extract, yohimbine, alpha-lipoic acid, poly-thyronine, chromium, B-vitamins, dipotassium phosphate, silicon dioxide, magnesium stearate, titanium dioxide, gelatin and FD&C blue #1 and green #40.

What are the active ingredient in Synedrex?

The active ingredient in Synedrex are methylxanthine, sulbutiamine, sandalwood extract, yohimbine, alpha lipoic acid, poly-thyronine and chromium.

Does Synedrex work?

There’s no scientific research proving the effectiveness of Synedrex. There are studies linking chromium to weight-loss, but this ingredient is common and can be found online for less than $5.

How much does a bottle of Synedrex cost?

A bottle of Synedrex costs $54.99.

Where can I buy Synedrex?

Synedrex can be purchased using their Official Site.

What is Synedrex’s BBB rating?

The BBB rating for Metabolic Nutrition, the company behind Syne, is a concerning “C”.

How do you take Synedrex?

You take one or two Synedrex capsules per day. The website recommends not taking two pills within 15 hours of each other and not taking prior to sleep. A bottle lasts between 22 and 45 days.

Who makes Synedrex?

Metabolic Nutrition makes Synedrex.

Is Synedrex for men and women?

Both men and women can use Synedrex. The ingredients don’t address specific gender needs.

Do you need to “cycle” off of Synedrex?

You don’t need to “cycle” off of Synedrex. The website recommends stopping use for two weeks after using it for 12 weeks, however.

Do I need to exercise with Synedrex?

You don’t need to exercise with Synedrex, but the company states optimal results occur when you combine with diet and a fitness plan.

Is there a guarantee with Synedrex?

Synedrex offers a 30-day money-back guarantee.

287 Synedrex Reviews

  • Loved the product.
    Tony (Verified Purchase)

    I am on my 3rd day using synedrex. I take these in the morning before breakfast….maybe 15mins before. The first day was really bad in the sense of jitters and a crazy caffeine overdose feeling, 2nd day better, still pretty strong, though today 6 hours after taking the tablet I feel really light headed and not as motivated as the first 2 days. I didnt have a problem sleeping the last 2 nights.

    • carmen

      I took it this morning for the 1st time with a protizyme shake and left walking for an hour and fell great when I got back I started to feel really nautious and have spent whole day in bed, Will I feel better tomorrow?????

      • Christina (Editor)

        Hi Carmen, some dieters also experienced nausea. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.

  • Loved the product.
    Jill (Verified Purchase)

    I went to the gym on it and I was PUMPED!! I had a great workout.

  • Able to lose weight without workout
    al (Verified Purchase)

    i’m not the type of person to be on a bandwagon, but i been using synedrex for 2 weeks and lost ten pounds without working out looking forward to getting in the gym with it.

  • Questions about side effects
    eddy (Verified Purchase)

    hi , i am using synedrex 15 days ago , but i dont know how to finish from the side effect specially the jitters and insomnia .how can i resolve this issue . and it should be taken before breakfast or after . Thanks a lot

    • Christina (Editor)

      Hi Eddy. This is a common side effect for some dieters. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.

    • Ryan

      Actually you only take up to two a day I have been using synedrex from about 3weeks and have lost over 20 pounds I only take one pill a day and if you buy from suppliment ware house myou can get it for like 30 for a 45 days supply if you use the price compare to a sketchy website that has a rediculously low price this is my second cycle and I would suggest anyone looking to lose weight use this product also the jitters disappeared after a week or so my rating is a 5/5

      • khriz

        Im in my third day, but i had a question. Do you have to take it everyday or just the days you go to the gym? because i was planning on taking it only on gym days…

        • Ken

          I would take it everyday, but after two months of taking it take a month to two month break from taking it at all.

          That way you keep your body guessing, but keep going to the gym regular schedule and keep your diet the same. DIET DIET DIET. It’s not just the pill doing the job for you. ITS YOU!

          My trainer recommended this product to me, and it’s a great product!

      • Sue

        I have been on Synedrex for 4 weeks now I have lost only 8 pounds. I eat less than 1,000 calories a day and I walk for about 45 minutes everyday. Other people comment that they have lost over 20 pounds – what I am doing wrong?

        • Christina (Editor)

          Hi Sue. All dieters have different weight loss results. Some users loose weight faster/slower than others.

        • Valerie

          Wow, Alan. Kinda harsh.
          It is true though, eating less calories wont promote weight loss. I have been on Synedrex for 2 bottles now, with a month break in between and I have had great results. Eat well, keep walking. You need good calories, that’s it. Keep at it. It takes 4 weeks to notice a dfference in yourself, 8 weeks for your spouse to notice and 12 for your friends to notice. Keep it up!

        • Anonymous

          you are not eating enough, your body is in survival mode and will not let go of fat stores.

        • Anonymous

          Eat more you should be at approx 1800 calories a day.
          By eating clean a proper diet will increase your metabolism. 5 meals a day. Pills will only give you a slight advantage. Keep up your workouts. Weight loss occurs over months. Don’t get discouraged.

        • Juan Pla

          Not enough food, too much cardio, and not enough emphasis on weight training. You need to sit with a professional to figure out your specific caloric needs as well as the proper training program for your goals. Blind caloric recommendations will not do.

        • Joshua

          I’m willing to bet that you’re not doing anything wrong and that your body and synedrex don’t cooperate with each other.

        • D

          i dont think some of yall have tried using syndrex… ive been on it for about 2.5 weeks or so and have lost 15lbs. When you are taking syndrex if you eat more than 1000 calories in a day you feel bloated as crap. I usually only take in around 750 on days I take it and that includes drinking cranberry juice. Seriously, how do yall figure 45 minutes of WALKING is TOO MUCH cardio?!? I go to the gym 4 times a week, lift weights for about 1.5 hours and do 30-45 minutes of running on the eliptical. Lastly, I usually take the pill m-f and take off on the weekends and eat a nice meal on saturday and sunday. This will make you gain a couple lbs from the water your body is now retaining since syndrex eliminates water weight, also will promote speeding up metabolism. So basically I have been losing about 5-7 lbs from m-w then start to level off, gain about 2-3 lbs over the weekend, then 5-7 again m-w so avg around 3-5 loss per week. been working for me so far. ALSO note, weight loss is always going to depend on eating habits, exercise, how overweight you already are or arent. I plan on only taking until I finish the bottle to speed up weight loss to where I want to be and then just maintaining weight.

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