Updated: 07/11/2017 - Site sponsored by Dietspotlight Burn
By Summer Banks Jun 27, 2017

A diet product’s worth depends on whether it helps people lose weight. Let’s find out if Synedrex works. We needed to learn as much as possible about the ingredients, side effects, and clinical support. We also took a long, hard look at customer experiences. We broke it all down and condensed it to give you the info you need.

Synedrex Readers: Click here to find out why we're giving away samples of our product, Dietspotlight Burn.

What is Synedrex?

First off, Synedrex is a thermogenic supplement [1] supposedly helping to boost metabolism and burn fat. The ingredients are methylxanthine, methylpentane citrate, sulbutiamine, sandalwood extract, yohimbine, alpha lipoic acid, and poly-thyronine. The company recommends not taking more than two capsules per day. The small container means there’s no trouble taking them on the go. [2]

The company behind Synedrex, Metabolic Nutrition, started the business online in 1997. Trusted retailers and the official website sell the supplement. We like that the ingredients are available for the dieter and that we found some positive comments, but read on…

Synedrex Side Effects – “Do You Need to Worry?”

The first negative we found was with Synedrex side effects, which could be associated with methylxanthine. [3] “No dieter wants to feel shaky and jittery after taking a product,” says our Research Editor. “You can have increased energy and metabolism without the problems.”

As one dieter puts it, “The side effects while on it included excessive sweating, jitters and insomnia.”

Another user reports, even more, Synedrex side effects, ”It gave good energy, but it was too much. It made my heart feel racy.”

During our research, we did stumble on a few dieters who didn’t have the same problem. One said, “The first day I started I got incredibly hot and enough energy to last a week, had a little trouble sleeping but by day 2 that pretty much went away.” [4]

A customer shared, “I haven’t had any of the side effects listed in any of these reviews.”

Synedrex Customer Testimonials

Ineffective – “Frequent Complaint”

Probably one of the biggest issues with a weight-loss supplement like this is effectiveness. Clinically speaking, there are some energy boosters in there that could increase metabolism enough to affect calorie burn, but no two dieters will react the same. According to some, Synedrex ingredients do nothing to help you lose. “I didn’t lose any weight. I will look for a better fat burner,” a user reports. [5]

Another dieter with the same problem says, ”There was no change in my weight at all.”

We did read some supportive comments along the way. As one user said, “Keeps me going. Makes me sweat.”

Another commented, “I only take one pill per day, in the morning and feel it helps sustain my energy all day.”

You only need one negative, like an adverse reaction, to ruin your chance of long-term weight-loss success. In the case of Synedrex, if the side effects are as harsh as dieters report, not matter if quality research doesn’t report such issues in most participants, that’s a bad sign.

The Science – “Is There Proof?”

We visited the Science Center portion of the Metabolic Nutrition website to see if there was any support for the weight-loss product. We found articles about supplements and exercise, but no research. The most important parts are caffeine and yohimbine, [6] two stimulants. We know these ingredients boost energy and promote a stronger metabolism, but too much can do more harm than good. Based on the side effects there may be too much in Synedrex. At DietSpotlight, we need to see facts to support claims. If there’s none out there, or if the formula may cause issues, that’s not a good sign.

Also: read our Dietspotlight Burn Weight-Loss Kit review »Synedrex Ingredients

The Bottom Line – Does Synedrex Work?

So, will Synedrex help you lose weight? The business has been around for 20 years, and some dieters do report positive results, but we feel uncomfortable giving our support because of the lack of clinical support. Plus, it bothers us that dieters reported side effects and lack of results.

If the time has come to shed off the extra weight, our suggestion is to find a supplement that contains clinically supported ingredients, with no known side effects offered at a price you can afford.

Among the best products we’ve found this year is one called Dietspotlight Burn. The proprietary blend is a combination of ingredients shown in published scientific research to spur metabolism and boost fat loss. Dieter’s aren’t talking about negative side effects, and users report seeing great results.

Also, the company that makes Dietspotlight Burn is so confident in the formula they’re offering a Special Trial Offer, which we like.

Previous Synedrex Review (Updated July 9, 2014):

Synedrex - What You Should Know

Synedrex is a pill form diet supplement that is advertised to help dieters shed fat and water weight by controlling food cravings. This diet pill is also supposed to give dieters an endless supply of energy, block carbohydrates and help to curb food cravings similar to GNC Burn 60. Synedrex is manufactured and marketed by the company Metabolic Nutrition. The company unfortunately has an unpleasing BBB rating. Looking at the ingredients one can see that there are some fat burners on the list; both green tea and garcinia cambogia are well known fat burners that have been shown in some studies to produce results. There does seem to be some disparity among websites that claim this product does not work as well due to insufficient amounts of these fat burners.

List of Ingredients of Synedrex

Chromium, caffeine anhydrous, green tea extract, garcinia cambogia, l-tyrosine, l-carnitine, HPMC, cocoa extract, 5-HTP, and jojoba bean.

Product Features

Synedrex is a diet pill that is advertised to give energy, block carbohydrates, raise metabolism and help dieters to lose extra pounds. Identical claims are made by Plexus Block. Dieters are instructed to take one or two capsules twice daily. On average the product carries a hefty price tag of $50 or more for a bottle of 90 capsules. If an individual two capsules twice daily as the label suggests the 90 capsules will last less than a month. The alpha lipoic acid found in Synedrex is regularly referred as an abundant antioxidant because it is both fat and water soluble, it does appear to possibly be useful for fat loss and the prevention of additional fat gain.


  • Synedrex does have added vitamins and minerals in addition to the fat burning ingredients.
  • The website has nutritional information and other diet related information as well as supplements.
  • The website also contains customer reviews and testimonials.


  • Synedrex contains copious amounts of caffeine with over 350 mg per dose. This large amount has been known to cause serious jitters, agitation and dehydration when taken over time.
  • At over $50 per bottle on average, this is one of the more expensive diet pills on the market.
  • There is no real diet plan or exercise plan included on their official site, just the pills to be taken along with a health and fitness plan of the dieter’s choosing.
  • Once dieters stop taking the pills, there is the chance that weight could return since there was not a learned modification to eating and lifestyle habits.

Conclusion on Synedrex

Synedrex does have many customer reviews and seems to help some dieters to achieve results. It is suggested, as with all diet pills, that users follow a sensible eating and exercise plan to achieve the best results. Overall this looks to be an average diet pill with a very large amount of caffeine in addition to other energy substances. Synedrex is almost like an energy drink in pill form and as such will pose the risks of the same side effects such as agitation, jitters and insomnia as well as dehydration. Read up on Synedrex Side Effects. Similar side effects are often reported with uncertain doses of stimulants like with Adaptogen or Absolute Nutrition Garcinia Cambogia. While the product may provide results it is important to remember that there are much less expensive ways to get caffeine.

Synedrex is a "Powerful Stimulant" that claims it can boost metabolism, cut fat and even smooth out lines. There is a Science Center, but we didn't find any compelling science or research of any kind. The fact that caffeine is a big part of the formula is clear, but you're not told just how much is included.

Synedrex Ingredients and Supplement Facts

Serving Size: 1 Capsule
Serving Per Container: 45
Amount per Serving% DV
Proprietary Blend920mg*
- Methylxanthine**
- Methylpentane Citrate**
- Sulbutiamine**
- Sandalwood Extract**
- Yohimbine Extract**
- Alpha Lipoic Acid**
- Poly-Thyronine**

Other Ingredients: Dipotassium phosphate, microcrystalline methyl cellulose, silicone dioxide, magnesium stearate, titanium dioxide, gelatin

We researched Synedrex ingredients in order to give you the information you need.


Methylxanthine, also known as xanthine, is a chemical found naturally in body tissues and fluids.

What Is It Supposed To Do?

The main purpose of methylxanthine is increasing alertness in the nervous system, although it may also help asthma.

Clinical Research

According to a study published in Canadian Journal of Applied Physiology, “The effects of ephedrine, in conjunction with methylxanthines and aspirin, in humans appear unequivocal but include various cardiovascular side effects. None of these compounds have been tested for their effectiveness or safety over prolonged periods of time.” [1]

You may want to try Dietspotlight Burn, which has clinically tested ingredients.


Sulbutiamine is a chemical containing two thiamine molecules. It is thought to be found in the brain.

What Is It Supposed To Do?

Not to be confused with sibutramine, an appetite suppressant, sulbutiamine is a compound used for memory, fatigue, and the health of the nervous system.

Clinical Research

According to information published by the American Society of Health System Pharmacists, “Although thiamine has not been shown by well-controlled trials to have any therapeutic value, the drug has been used for the management of poor appetite, ulcerative colitis, chronic diarrhea, other GI disorders, and the cerebella syndrome.” [2]

Sandalwood Extract

Also known as East Indian sandalwood, the sandalwood tree, where the sandalwood extract is derived from, is not easy to grow due to the specific conditions it needs for proper cultivation.

What Is It Supposed To Do?

Sandalwood extract is used traditionally for aromatherapy, spiritual use, and commercially for perfumes.

Clinical Research

In a study published Phytotherapy Research, researchers concluded about sandalwood extract that, “However, until further studies are conducted to determine safety regarding internal use, this herb warrants caution with use.”


Yohimbe is a tree found in Africa. The bark is used to make medicines.

What Is It Supposed To Do?

Yohimbe has been used for a wide variety of treatment, including erectile dysfunction, depression, athletic performance, weight-loss, high blood pressure, and much more.

Clinical Research

In a study published in Research in Sports Medicine, researchers studied the effects of yohimbe on athletes. In conclusion, “Nonetheless, yohimbine supplementation appears to be suitable as a fat loss strategy in elite athletes.” This does not hold promising results for those who are not at this level of exercise.

Is There Anything Out There That TRULY Works?

Before you give up on weight-loss, we suggest you try the Special Trial Offer from Dietspotlight Burn. They have clinically-tested ingredients and consistently positive customer reviews. Click here to try out the supplement.

Synedrex Side Effects:

In the world of weight-loss supplements, even natural solutions may not be completely free of side effects. It’s possible to experience a negative reaction to any type of formula. Though Synedrex side effects don’t happen in all users, they do exist for some.


When you feel unsteady, weak, woozy or even faint, it may be a dizzy spell. Dizziness might also be called vertigo and makes it seem like the things surrounding you are spinning.

What causes dizziness?

Dizziness is a symptom of many health issues and a side effect of some medications and supplements. It may be cause by simply standing too fast or something much more serious. Many people associate dizziness with overconsumption of alcohol, migraine headaches and specific medications.

Racing Heart Rate

If your heart feels like it may explode out of your chest or it’s beating very fast, it’s a racing heart rate. This is also known as tachycardia. While a racing heart rate isn’t always serious, sometimes it can be a problem requiring medical attention.

What causes a racing heart rate?

A racing heart rate may be caused by a serious heart condition, poor blood supply to the heart or even emotional stress. It may be a sign of an infection or a heart valve problem. It may also be caused by drug or alcohol abuse or even over use of caffeine. [1]


A discomfort felt in the abdomen making you feel like you may vomit is known as nausea. It’s a queasy feeling and causes a large amount of discomfort.

What causes nausea?

Nausea may be caused by many different things from something you’ve ingested to a physical injury or even from many different diseases. [2] Medications and supplements may cause nausea if your body is having a negative reaction. It may also be caused by head injuries, such as a concussion.


The jitters are an uneasy feeling of nervousness or irregular movement. You may feel very unsteady or incredibly anxious.

What causes the jitters?

While the jitters may be caused by anxiety or stress, they may also be caused by ingesting too much caffeine. Certain medications and supplements may also cause the jitters.

Synedrex side effects are not common in all users, but some have reported dizziness, a racing heart rate, nausea and jitters, among others. Make sure you protect yourself by consulting with your doctor before taking any weight-loss supplement, especially if you’re pregnant, nursing, suffer from a medical condition, are taking prescription medication or you’re under 18 years of age.



Syndrex is a thermogenic that’s supposed to increase heat production and thus boost weight-loss. Though side effects aren’t shown to happen often, these are what some users have experienced.


“I was already feeling horrible heat flashes to cold flashes to dizziness and spinning like being drunk and jittery to a sickening point…I went home and by 3 in the afternoon I was puking.”    Sarah


“I have had a dull headache, I feel off balance,i dont feel like my mind is clear, it’s crazy.”    Pamala


“My heart pounds like crazy even pulsates hard in my neck. I’ve vomited. I’ve had diarrhea.”    Dawn


“I felt nausea, jitters, sweats, chills and threw up and couldn’t settle down all day and night…I felt heart palpitations and increased blood pressure and I didn’t even exercise! I didn’t have an appetite because I was so nauseous.”    Andrea


“Horrible jitters, and for hours I had severe nausea. The only reason I didn’t vomit was because I didn’t eat anything and stayed very still while taking deep breaths when the urge would hit me. No sleep last night, despite bedtime being 12 hours after I took the ONE pill. Now, the next day, I’m still jittery.”    Jennifer


“…I started to vomit like there’s no tomorrow…in less than 3 hours of me taking the pill. My heart is pumping so fast I am having hard time breathing.”    Kathy


“…before even beginning my workout routine, my heart rate spiked from a resting rate of 60bpm to 205bpm in about 30 seconds. It lasted for about 30 minutes, before it slowed back to 60bpm.”    Mike


“I became dizzy unable to breathe normally my heart was beating so fast it didn’t feel like it was beating at all!! I was sweaty then hot and all my extremities were cold clammy and I felt very panicky.”    Shelley


“I became dizzy unable to breathe normally my heart was beating so fast it didn’t feel like it was beating at all!! I was sweaty then hot and all my extremities were cold clammy and I felt very panicky.”    Maria


“…the first day I had no appetite just tons of energy. The second day I was nauseated all day…After 7 days I couldn’t take the nausea anymore so I quit taking them. I was constantly nauseated for an entire week without the pills”    Corrina


Looking for a supplement that doesn’t give you irritating side effects? We have one you may want to check out. Dietspotlight Burn is made with clinically tested ingredients and supported by users reviews that consistently report weight-loss.

There comes a time when a supplement deserves a bit more attention, like Synedrex, so we’ll concentrate on Synedrex side effects. Further consideration will be given to ingredients and clinical research. We’ll also analyze hundreds of consumer comments. Afterwards, we’ll summarize the info to give you the bottom line.

What You Need to Know

To start, Synedrex is a fat burner containing caffeine, sulbutiamine, yohimbe extract, methylxanthine, sandalwood extract, alpha lipoic acid, poly-thyronine and B-vitamins, among others. The recommended serving is one capsule per day, which supposedly results in increased weight-loss. One of the benefits is ease of use.

The product, introduced as a fat burner by Metabolic Nutrition more than 25 years ago, appears to include some natural ingredients, a good start. You can shop for Synedrex on the official website and through online retailers. We like that the company has a strong position in the market and that we located some positive customer comments, but read on…

Skin Irritability

The first issue with Synedrex side effects is skin irritability. “One of the main purposes of weight-loss is to love the skin you’re in,” said our Research Editor. “If a supplement like Synedrex leaves you irritated, that may be a sign to try another product.”

“I took it and within 30 min. I felt like my face was on fire…then that sensation spread to my arms then my stomach. When I looked in the mirror after I felt my lips tingling I seen I started breaking out in hives,” commented a dieter.

“I took 1 pill of Synedrex yesterday at 1:30 pm and 30 minutes later I felt hot all over. I had tremors and I couldn’t really focus,” said a user.

Increased Heart Rate – “Yikes!”

Based on customer comments, Synedrex side effects include increased heart rate. “I became dizzy unable to breathe normally my heart was beating so fast it didn’t feel like it was beating at all!! I was sweaty then hot and all my extremities were cold clammy and I felt very panicky,” commented a user.

“I recently started taking these pills and now I’m going to stop. I started feeling very faint, dizzy, sweaty and nauseous, all of the symptoms that EVEN the label on the bottle tell you can happen. Happened to me,” reported a customer.

“It gives you an intense level of energy, but at the cost of jittery, shaky, anxiety filled days with a heart that feels like it’s going to give out. I’ve taken it 6 days a week for 6 weeks, but I’ve been forced to quit due to the compounded side effects, and the different ones that start appearing the more you take them. Headaches, nausea, insomnia,” said a consumer.

Throughout our extensive research of supplements, we’ve found that something small, like increased heart rate, could reduce the chances of long-term success. If Synedrex causes negative reactions of any kind, there’s a concern [1].

The Science

According to the Synedrex website, the formula in the supplement is scientifically engineered, meaning the product is supposedly linked to clinical research. After a bit more investigation, we couldn’t locate studies supporting the claims. What we did find was information on sulbutiamine, an ingredient in Synedrex. According to the National Institutes of Health, side effects may include headache, constipation, dry mouth, back pain, nervousness and difficulty falling asleep, among others. At DietSpotlight, finding evidence a weight-loss product works is critical. If a company can’t provide all of the details, we have to walk away.

The Bottom Line

After taking a close look at Synedrex, here’s our decision. We like that the company has been in business for decades and that we found some positive customer comments, but we can’t recommend it because there’s no published clinical research supporting weight-loss claims [2 ]. Plus, we’re also concerned that increased heart rate and skin irritability could cause bigger concerns [3].

If you’d like to lose those extra pounds, we recommend going with a supplement supported by published clinical research, with no one reporting negative side effects [4].

Dietspotlight Burn is one of the best supplements we’ve researched this year. The product contains a formula consisting of a four-ingredient proprietary blend, which has been shown in published scientific studies to help dieters increase metabolism and ignite fat loss [567 , 8]. No one is reporting negative side effects and comments on the web highlight dieters seeing exceptional results.

The company that makes Dietspotlight Burn is so confident in the supplement, they’re providing a Special Trial Offer, an excellent choice.

Synedrex Questions & Answers:

We refined hundreds of customer comments about Synedrex into this helpful FAQ.

What are the side effects of Synedrex?

Synedrex is another pen name Synedrex goes by. Potential Syne side effects may include nausea, increased blood pressure and jitters, according to some customer reviews.

What is in Synedrex?

Synedrex ingredients are methylxanthine, sulbutiamine, sandalwood extract, yohimbine, alpha lipoic acid [1], poly-thyronine, chromium, B-vitamins, dipotassium phosphate, silicon dioxide, magnesium stearate, titanium dioxide, gelatin and FD&C blue #1 and green #40.

What are the active ingredient in Synedrex?

The active ingredient in Synedrex are methylxanthine, sulbutiamine, sandalwood extract, yohimbine, alpha lipoic acid, poly-thyronine and chromium.

Does Synedrex work?

There’s no scientific research proving the effectiveness of Synedrex. There are studies linking chromium to weight-loss, but this ingredient is common and can be found online for less than $5.

How much does a bottle of Synedrex cost?

A bottle of Synedrex costs $54.99.

What is Synedrex’s BBB rating?

The BBB rating for Metabolic Nutrition, the company behind Syne, is a concerning “C”.

How do you take Synedrex?

You take one or two Synedrex capsules per day. The website recommends not taking two pills within 15 hours of each other and not taking prior to sleep. A bottle lasts between 22 and 45 days.


What do users like about Synedrex?

Some users like that Synedrex increases energy above their normal levels. Customers also approve of the cost and the fact that you can use the supplement on the go.

What do users NOT like about Syne?

Dieters do not like the idea of side effects with a Synedrex. There are also comments about poor customer service quality and short 30-day return policy.

Who makes Synedrex?

Metabolic Nutrition makes Synedrex.


Is Synedrex for men and women?

Both men and women can use Synedrex. The ingredients don’t address specific gender needs.

Do you need to “cycle” off of Synedrex?

You don’t need to “cycle” off of Synedrex. The website recommends stopping use for two weeks after using it for 12 weeks, however.

Do I need to exercise with Synedrex?

You don’t need to exercise with Synedrex, but the company states optimal results occur when you combine with diet and a fitness plan.

Is there a guarantee with Synedrex?

Synedrex offers a 30-day money-back guarantee.

When taking a closer look at weight loss supplements that work best for health and fitness, Dietspotlight Burn came across as a noticeable product with four ingredients clinically shown to boost energy levels and help the metabolism run at a faster pace, resulting in weight loss.


Synedrex Scientific Abstracts:


Testing of the thermogenic reaction of 22mg ephedrine, 30mg caffeine, and 50mg theophylline was studied within human participants with a proclivity to obesity. It was found that the ephedrine/methylxanthines combination were two times as effective as the ephedrine by itself, raising the fasting metabolic rate in all participant groups. It normalized the decreased thermogenic response to a 1.25-MJ meal in participants who were predisposed to obesity. The studies had suggested that small doses of methylxanthines, when combined with ephedrine, could increase the daily energy expenditure of obese participants, largely by fixing their poor thermogenic food response. It had been concluded that ephedrine/methylxanthine could very well be a useful tool in the treatment of obesity. [1]


30 participants with diabetic polyneuropathy were recruited for this study. They were assigned sulbutiamine or no treatment to test the effects on glycemic control, the severity of neuropathy and electrophysiological parameters at the start of the trial and after the six week period. No substantial improvement in symptom scores was noticed in the groups. However, a significant increase in comparison to the baseline was witnessed in the sulbutiamine group (p< 0.05). Glycemic control in all participants didn’t change and remained consistent throughout the study. The sulbutiamine improved peripheral nerve function in diabetic polyneuropathy, but symptom scores remained the same due to the shortened length of the study. [2]


Human bladder cancer cells showed a more sanative pro- apoptotic effect to frankincense. Sandalwood oil displayed similar potency when it came to suppressing viability of both UROtsa and J82 cells. Even though both oils had activated similar pathways like inflammatory interleukins (IL-6 signaling), they each had a unique molecular action on bladder cancer cells. The negative regulation of protein kinase activity, as well as G protein-coupled receptors, had been activated by sandalwood oil. In conclusion, sandalwood essential oils had different mechanisms than frankincense. However, both leading to the death of cancer cells.[3]


There had been no remarkable differences in body mass and muscle mass in trials (p > 0.05) following supplementation protocol. The percentage of body fat greatly reduced in the yohimbine participants after protocol (9.3 +/- 1.1 vs. 7.1 +/- 2.2%; p < 0.05). Also, the fat mass had been significantly reduced in the yohimbine as opposed to the placebo group (7.1 +/- 2.2 vs. 9.2 +/- 1.9%; p < 0.05). There were no differences in exercise (bench press, leg press, vertical jump, shuttle run, power test results, and dribble) during trials (p > 0.05). No participants had reported adverse side effects from the yohimbine. The conclusion is that yohimbine supplementation mixed with resistance training doesn’t substantially change body mass or muscle mass or performance indicators. It was found that yohimbine seems to be a useful way for athletes to lose fat. [4]

Learn More About Dietspotlight Burn »
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Dietspotlight, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 3.6. From 410 votes.
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Leave a comment or review

Lyndsay (Verified User)

This stuff is poweful. I recommend to ALL to take half the capsule your first time. It gives you jitters if you take a whole one your first time because it gives you so much energy. And make sure to take it in the morning because you won’t sleep at night if you take it later in the evening. It’s also great at appetite control. The best supplement I have taken to help with my appetite. I have to make myself eat when I take stnedrex.


Hi shall I take it first thing in the morning before coffee and breakfast or after breakfast? Thank you

Maribel (Editor)

Hi Lolo, you may take before breakfast, just make sure not to take two pills within 15 hours of each other and not taking prior to sleep. Also, you can take one or two Synedrex capsules per day.

Machizo (Verified User)

I jus bought it yesterday and my question is do i havr to take this before breakfast or after breakfast? And again am eating jus vegetables as my diet, is it okay or i can eat anything? Thank you

Cameron (Editor)

You can take up to two capsules a day, though you may want to start with one according to the directions before breakfast. A vegetable based diet is good but may be hard to stick to. Try to switch it up.

  Possible to take two Pills

Is it possible to take two pills at the same time every morning?


Don’t … I take them and one is enough I sometimes feel way to energized and jittery but hands down does curb appetite which is what I need

Victoria (Editor)

Hi Rani. The website recommends not taking two pills within 15 hours of each other and not taking prior to sleep.

  Can I take it without exercise?
Your name

I have 1 question can I take it wothout going to gym cuz I cant go to gym for 3 months I have alot of exams in college but I can do cardio at home but still should I take it in the morning or before I start cardio ?

Stephen (Editor)

Hi! It is best to combine with exercise, cardio is a good option. You can take other in the morning. You may want to combine this with a proven fat burner. Of course be sure to ask your doctor before using any supplement.


How can i buy synedrex from your site


Hi Mohammad! Nop. You can buy it from Synedrex’s website.


Can you split the pill in half at first? is it powder in a capsule?


Hi B, it is best to follow the instructions and take as directed in the instructions, with a full glass of water for best results.


so i just start today. Just a question. I have to lose 40 pounds so i feel heavy and lazy. I don’t do exercise its ok to take this pill without exercise?????

Victoria (Editor)

Hello Mel. To achieve quicker and better weight-loss results, it’s best to combine with exercise.


second day! Im not hungry but i dont feel like yesterday that i wont eat at all. Well after 3rd day i have to take two pills lets see how work. I didnt weight my self but prob tomorrow i will because i need to know. This is my last option about pills

Anonymous (Verified User)

I want to ask if I took the pill and work out can I drink alcohol at night??? Or I shouldn’t take the pill if I have to drink tonight

Cameron (Editor)

Well, it is generally inadvisable to drink alcohol while on a diet. But certainly not while you are taking or recently took Synedrex.


Hey so I’m just thinking of taking this. I also currently on Animal Pak. Wondering if it would be a little too much ? Also any recommendation by anyone of which protein to use with this in combo ? Thanks LMK

Victoria (Editor)

Hi J.J., combining medications can be detrimental. Its always best no to, and please consult with your physician about it too!


I have a question.. I have been drinking a pre work out. E. S. P. Do I need to quit drinking that while taking SYNEDREX?

Cameron (Editor)

There should not be a conflict between the two, but ask your doctor before taking.

Cody Poplawski

Synedrex is a strong supplement to get use to. At first you feel a flu like symptom. Cold, jitters, loss of sleep, hairs stand all over your body, you are extremely spaced out or in depending on how you look at it. It makes you feel sick for the first couple days, just like everything else that you do for the first time. Smoke weed… first time you get sick. Drink booze… sick. Take a synedrex… sick! After about 2 days you start to get use to the product and it works as specified online. I have burned 15lbs in 2 weeks. Although I am in the gym 4 days a week and the pill suppresses your hunger. Protein drink in the morning for breakfast with your pills… (synedrex, thistle, fish oil, etc…) Oatmeal for lunch, chicken fish or steak for dinner maybe… 6oz and sides if I can eat them. Eat your protein first. Followed by vegis then everything else. DRINK A LOT OF WATER! A gallon throuout the day. If you drink water to fast it can be very deadly. Different story… look into it. If you have concerns let me know.


I just bought the product and I am very excited. I want to ask if the dosage should vary according to the current weight and weight goal.
I am 22 and I am 58 kgs, aiming to lose an average of 8kgs. Is the recommended dosage in the package good for me ?

Victoria (Editor)

Hi Amy! Yes, the recommended dosage on the package fits for everyone, please follow that.

detox program

Very good material compared to most of the other topics I’ve discovered. Continue the good work.

Maribel (Editor)

Hi! Thank you so much, we appreciate your positive feedback!


It’s my 2nd day trying synedrex. I haven’t weighed myself but I feel thinner. The side effects are unbearable. I ate breakfast with the pills & drank plenty of water. As far as appetite suppressant, it’s not that strong. I can’t take it, I can’t focus, I feel so jittery & I’m holding back from throwing up. I ran 2 miles to try & burn off the energy & still felt sick to my stomach. After trying to rest 4 hours after taking it, I still feel sick & I’m having sharp pricking pain in my chest. This product is not for me!


I was taking this product, the first day I felt like I was coming down with the flu. I was sweating with goose bumps and chills, I felt like I was going to vomit and I was shaking. I figured it would go away after a few days, I took the product for a week and each day felt the exact same. I had no issues sleeping and the effects wore off by 3 or 4 in the afternoon. I still have a large amount of the product sitting in my cabinet, could not return it, paid for it… looking for something else now.

  Will this show up in sports physical ?
Catherine (Verified User)

I have a question will this show up on a sports physical? I’ve taken this since February and i feel great and it’s working, but i get all the side-effects that everyone is talking about. I’ve been able to adjust, but I feel like my body has grown more “numb”. Is that normal? Will this have long-term effects on me if i keep taking it?

Candace (Editor)

Fortunately, Catherine, this product doesn’t contain ingredient that could test a false positive. As for the numbness, we urge you to seek out your doctor’s counsel; they know your body better. In the mean time try taking a break from this product.

  Tried twice,it worked for me !
Your Namelaura (Verified User)

I tried synedrex twice!!! And both times worked for me:)

  Not worth it for me
Edamar (Verified User)

I started this week on Monday…I felt awful all day and had trouble going to sleep. It suppressed my appetite but that is because I felt as though I was on the verge of vomiting all day. I skipped the second day so today is my 3rd day and 2nd pill and I feel terrible again. I have been feeling sick to my stomach all day. I like that my appetite is suppressed, but I DO NOT like feeling sick all day. This feeling is terrible and I am not sure if it is worth it. My friend is taking these and she gave me 4 to try and see how I do on them…I do not think I am going to purchase a bottle because the side effects are to much for me. My friend said she felt bad but started feeling better after day 5, but I do not want to suffer for 3 more days feeling like this. I will have to try something else.


I got all side effects of it, I recommend you trying only half dose a day. It really worked for me, it does the job and almost no symptoms at all. Also I readed in this page to eat dry toast, believe me it works. I now having a dry toast with cream cheese every morning before medication and more problems. Good luck!!


It made me feel that same way at first. After I tried “sandwiching” it between food. (Eating a little, taking the supplement, and then eating a little more) The stomach ache went away!

  All this amazing product
Shannon (Verified User)

I’m fascinated by the comments that I read though the effects are real, I sampled to try to find a solution. First of all this product although a weight loss supplement, isn’t designed for those who don’t exert themselves in the gym, no consume a greater amount of water, who may have a weak heart, high blood pressure, diabetes etc. Here’s the solution to the side effects. #1. I purposefully took 2 pills to see the results and yes every side effect was absolutely present. So if this is the effect of taking too much for my body mass and health condition then number 2 should be your choice. #2 I had taken 1 pill for one entire week with zero side effects drinking a decent amount of water and a bite of food. I had an unheard amount of energy that I appreciated very much. So to the solution, #3. Take one half of the daily recommended amount to see what your effects are if any and then begin to modify or increase to a full pill. I will confess that one of the great results was that I spend 3 hours Monday-Friday in the gym so my body was used to working out. All this amazing product has done with the proper dose, has enhanced my overall gym experience to the maximum!


Shannon.. you are correct , I felt the same way as I was reading the post.. never tried 2 pills a day because 1 pill did what I needed it to. I work out in the early morning so I never felt not being able to sleep. It was perfect for what I needed.. but each person is different in there workouts and the time the pill is taken

  not the only person having this problem

Ok so I’m sure I’m not the only oerson having penile problems with this product. The negative, it’s hard to stay erect. It seems to effect my testicles either enlarging one or shrinking the sack to the point of where my testicles move around which is weird and painful. Burning urination that can make you feel like you have an std…….. Maybe it’s an allergic reaction to me. I’m not being oerverted or funny. This has happened both times I used it. I wish the original oxyelite was still being made. If you have any questions or you can relate feel free to email me

Victoria (Editor)

Hi Joey. Please consult with your physician if you continue to have these side effects to make sure this product is safe for you to take.

  Suggestion on how to take this
Anonymous (Verified User)

Take one with a tall glass of water. Wait 30mins-1hr to eat becuase the pill will act as a laxative. Avoid any other caffeine drink for a few hours

  Suggestion on how to use this
Anonymous (Verified User)

With a large glass of water. Wait an 30mins-1hr to eat becuase it can act as a laxative. Avoid any other caffeine drink for a few hours.

  Wonderful but they are very strong
Nicole (Verified User)

Ive been taking these for a year now on and off. They are wonderful but they are very strong. They come in a case that allows you to dump some out which Is what I would do your first time. Dump about a quarter until your body gets used to it. These aren’t for everyone especially if you have a weak stomach. But they do work. I haven’t been exercising so ive only lost about 15 pounds on and off. But they DO CURB HUNGER like a beast. They do make you jittery and sweaty because its speeding up your metabolism. I know when I first started taking them I couldn’t sleep because I was wired but im used to it now. Im actually going to start using both this product and their phenolox product together. Don’t be scared they do work just very strong! you are welcome!


I buy empty capsules and divide them up into quarters. Don’t just dump and waste it.


Are the ones on ebay?


Is itching ok?

Maribel (Editor)

Hi, some users may experience itching side-effects. Please consult your physician about this, before continuing.

  Would this affect my drug test result?
fernando (Verified User)

So I’m worried becausee I am currently taking this product, I had to do a drug test for a new job I’m trying togetting, w it show up and if it does what can I do?????

Victoria (Editor)

Hi Fernando. There shouldn’t be anything in this product that would make you fail a drug test. Either way, please consult with your physician to make sure.

  Why am I experiencing pain?
elias boutros (Verified User)

it’s the first pill I’m taken and it giving me a testicular pain what us the reason ?

Maribel (Editor)

Hi Elias, so sorry to hear this, please consult with your physician immediately before continuing to take his product.

  I love this product !
Iliana (Verified User)

I love this product, started it 3 weeks ago and have lost 10 pounds so far. I have get all the side effects of it, so I divide I cap into half and symptoms got better. I take it after breakfast, don’t recommend on empty stomach and dry toast HELPS 100% My 1/2 dose a day does the job, going for another 10 pounds!!

  i am over 40 will this effect me
Isela Cruz

I want to know if im over 40 this pill afect my mood?

Victoria (Editor)

Hi Isela. Mood swings and irritability is among the side effects users have reported experiencing. Please consult your doctor before taking this product.

   I feel good
Wojtek (Verified User)

I started using Synedrex on the 1st of February and it’s damn awesome. At the beginning I was taking half of a cap so that my body could get used to it and after 1,5 week I went for a full cap. It works great but you have to drink a lot of water. I’ve ignored that warning and believe me that waking up with your head spinning and vomiting for few hours wasn’t cool. Apart from that I can’t say any bad things about the Synedrex. I’ve lost nearly 7 kilograms in 29 days and I feel good.

  it's worth it to me
bohyga (Verified User)

The last article seems accurate, I got slimmer the first week, I do moderate training everyday, no more than an hour, i run 30-50 bleachers three times a week, my lower stomach and waist went nuts(thinner) in no time, I eat any where from 1,000-1,400 a day some days less, consistently my meals are at least two slim fast, with 20grams of protein per shake, and I have the regular(usually drink whichever). Definition came really fast! It does give me a ton of energy! Too much!!! But I do use the energy, I workout about an hour after taking the pill(one pill a day, sometimes every other day) yes it is hard to sleep but I will catch up! So no biggie, it’s worth it to me.

  This thing is horrible! DO noy recommend it!
Lisa (Verified User)

I took one pill with breakfast and can’t stop feeling jittery and have been throwing up all morning! This thing is horrible! I DO nOT recommend it!

  should i stop immediately
CG (Verified User)

I’m eating healthy and exercising, but today after my work out I got a rapid heartbeat and a bit sweaty. Should I stop immediately? I feel that I’m not eating enough calories a day and that may have effected me today.

Victoria (Editor)

Hi CG. It is a possibility this happened due to not consuming enough calories, as you said. But, it could also be a side effect from Synedrex, as other users have reported having a rapid heart rate. If you continue to have these effects, please consult with your physician before continuing to take Synedrex.

  loose my weight
Izzy (Verified User)

My fiance and I started this product on March 27 (Friday) and already see results. I already lost about 5lbs and my fiance lost a total of 10lbs. I have NO side effect at all other than ZERO food cravings! We do drink lots of water to keep hydrated. This pill must be taken as soon as you wake in the AM to avoid insomnia. According to my man, there is no penile issues and he likes the way the pill makes him feel during sex. Five stars for that! LOL


I love this product too, I was 195 pounds and I’m now down to 167 lbs 30 pound the lightest I’ve been in years….its almost a year later and I do walk and excersise, can just take something without a goes…. I love love this product…. this a great product and hard to find.


All I got to say is this I don’t know what everyone on here is talking about this is my second time using this pill and it has always been great for me sometimes I forget to eat and have to force myself it gives me so much energy in the gym as a pre-workout it doesn’t make any sense and the thing about it is I have an immune disease myasthenia but when I take this I feel like I’m in remission this stuff is amazing take it from me I’m 52 I have never had a problem with this stuff it is off the chain!!!!!!!!!!!!!!!!!!!!!


I love this product, that’s for sure I am a fitness competitorcompetitor and has used it for three shows. Within 3 months I lost 20 pounds, with proper, excersise,drinking plenty of water. NO SIDE EFFECTS!! STAY HYDRATEDHYDRATED by drinking plenty of water. I give this product***** 5 stars.Thanks Metabolic Nutrition!!!

  Can you take any drink cofee with
Mardy ismail

Can your drink any tea coffee or green tea with the capsule

Victoria (Editor)

Hi Mardy, it is not advised to take this product with other products that contain caffeine.

  take this with prescription medicine
kim parkerson

can i take this with prescription meds? blood pressure medicine, cholesterol medicine?


Whatever you do, DO NOT take it if you have issues with blood pressure.

Victoria (Editor)

Hi Kim. Please consult with your phsycian to make sure none of your medications would interact with synedrex.

  I had great results
t (Verified User)

First day of Synedrex i did not eat before i took it and it DID make me feel shakey until after i ate. the rest of the days i took it i ate before and had several SMALL meals throughout the day and had no adverse side effects. it gave me energy and made me want to work out or do something besides lay in bed. i had no trouble sleeping if i took the pill in the morning around or before 10.
i have had 2 friends take this and had great results without changing diet or exercise. They recommended taking 1 pill a day for 3 days straight and then resting one day then taking 3 days and resting. for a week and a half and lost 5-10 lbs and kept it off.
i have had great results so far but you need to keep hydrated and not go on an empty stomach.

  46 years old sports day
zaki kabbad

I have 46 years old I do 2 hour sport per day
But I have a little anemia can I take synedrex

Victoria (Editor)

Hi Zaki, It is best not to take if you suffer from Anemia. After careful research, we discovered that green tea can cause liver problems when consumed in large amounts, it can also reduce the absorption of iron.


1. Apparently the majority of users missed the word: SUPPLEMENT. A person should ALREADY have excellent training protocols and a excellent eating/nutrition program. 2. If you are losing more than 2lbs weekly, it’s water, NOT FAT. 3. Taking a full dose the very first day is NOT recommended. It is recommended to work slowly to full dose. 4. The ab belt DOES NOT replace a gym session EVER. 4. List the ingredients of your “recommended” product please. The amounts used are not even clinical doses.


Just get clenbeuteral


You need to eat, at least small amounts , it is not healthy even if you are not hungry, it will eventually catch up to you


ive only been taking this for 2 days. Just the normal effects that any Energy pillbut to those of you saying that you feeling nauseated or really jittery just with any guy journey as a nutritionist key and I would recommend taking it with food. Something with Substance but still healthy. Favorite is a Egg whites and turkey bacon and a slice of whole toast I think that should help with nausea The misconception with dieters is the diet pill is supposed to be the main souce if their weight-loss. If used properly diet pill should only aid to your weight-loss not sure it should not be the main ingredients.nutrition and exercise should be the main reason so that it helps you keep the weight off when you stop taking the diet supplement



  So far doing great
steph (Verified User)

So I’ve been taking synedrex for about two weeks and a half, and I’ve lost 4 inches of my waist (I don’t know how many pounds because I don’t have a scale) I’m not working out and I’ve been trying to eat clean but I haven’t been perfect on it.
Side effects that I have are fast heart rate, I’ve been going to the bathroom like 2 a week so I have to take laxatives and I drink about a gallon of water a day. But I can say I feel great, lots of energy and I feel happy.


I am just curious if anyone experienced nausea and dizziness (no vomiting) and if you continued taking the product did it go away. I drink a lot for water and I take my pill during my breakfast.
The energy is great but I feel light headed and dizzy (especially, during a workout. If it’s something my body will get used to, then I’ll continue but if I’m going to feel this crappy every time then I certainly will not continue to take it.



I just want to ask you from were y get it thanks


I just tooky first one and I feel light headed, dizzy and nauseous. I keep thinking I have to throw up because I keep burping/heaving but never actually throwing up. Are you still experiencing this? I’d like to know if maybe I should just stop.


Omg I just took one pill today and I had same symptoms as you. I’m wondering if it will eventually get better or worse???

Victoria (Editor)

Hello. Please consult with your physician if you continue to have side effects to make sure this product is safe for you to take.


The only time i get that feeling is when i take to much. Just cutback the dose you should be okay.

Victoria (Editor)

Hi Nina. If you continue to have these effects, please consult with your physician before continuing to take synedrex.

Victoria (Editor)

Hi Anthony. Some dieters claimed to have experienced nausea and dizziness. Please consult with your physician if you experience these side effects.

  I wouldn't take this again
veronica (Verified User)

I got a couple trial pills and I took one this morning and I feel very awful like if I would have taken 2 energy drinks. Everybody is different but I wouldn’t take this again 🙁

   it does cause a postive test result

Actually, it does cause a postive test result

  simple Multi-vitamin
Jeremy (Verified User)

Got a bottle… LOVE IT… going to start a new stack of Synadrex, Thyrene, Phenolox, & a simple Multi-vitamin (and cellucor CLK) this week. 🙂

  Feel amazing so far
stephanie mcilwee (Verified User)

So i took synedrex years ago and i lost 60 pounds.
This year i gain like 30 pounds so and my vacation in December is coming so I needed to take this again.
This is my fifth day taking it and I lost 5 pounds. I feel amazing and the side effects aren’t that bad. I have cramps, dry mouth (I like it), my neck hurts sometimes but its ok.
I smoke weed before going to bed so no problem trying to sleep.
I will come back in a couple of months before my vacation to tell you guys how much I lost.

   i have100 kg of body wieght,

Im not sure whether I take it or not. Im 22 i have100 kg of body wieght,and I go to the gym. All those who took it do u recomend it 4 me?

Victoria (Editor)

Hi Dean. Please consult with your doctor before taking this product to make sure it is safe for you to take.

  Make me feel "not normal"

This stuff is CRAZY!!! Never had more energy….probably too much. It definitely suppresses your appetite but I feel very jittery. Would not recommend if you are sensitive to caffeine….guess I am. Make me feel “not normal” and nauseated/dizzy. Probably not going to take it again. I would recommend it only be taken if you plan on doing an Iron-Man Triathlon.

  It has been working so far
christian (Verified User)

I have been taking both the synadrax and the hydravax, I started taking them on July 9th Iv been taking them in the morning and I drink about a gallon to two a day but I also work out side all day long. It has been 4 days I have lost 7 pounds and I work out and for about and hour in half then run for about an hour. I felt jittery the first morning for about 15 mins but after that I have not had any problems I do eat it with some wheat bread and about a bottle of water. And I do not have any problems with sex I actually see my stamina lasting a lot longer and my heart rate only gets higher when I run. It has been working so far. But I do say to take the hydravax with it. It’s not worth it without it.

Hussein (Verified User)

I bought my synedrex from nutrition depot 4 days ago , first day was amazing , though i ate abit yet my stomach kept playing games with me as if i was on the urge of vomiting yet i came through it fine, i was energetic the whole day , but today was the worst to me i took synedrex and waited till it kicks in and then after that i drank my Pre-workout , all i can say is im having unlimited energy i worked out for an hour and half, was heavily dizzy and hands were tingly and numb that has never happened before, now im having fast heartbeats, yes i lost in 3 days and 2 days of working out properly i emphasize the PROPERLY and ended up losing 6 lbs , but i dont think it is worth it especially with the uncomfortness that im having right now i took it at 7 pm now its almost 6 pm and i still can’t sit and relax my body is Cold even though no AC. the funny part i thought i was dying lol but you know your mind plays tricks , though take it easy on synedrex would recommend taking it one a day and then cycling it off for 2 days dont over stress your body , you want change and weight loss go out and achieve it dont play with your body like that.


Great energy but I had a great deal of pain in my stomach… Has made me throw up a couple times….. Stopped using


I agree with Brittany I just got it frist day I was dizzy but after that had a great deal of stomach pain my stomach now

  Synedrex yesterday
Karen (Verified User)

I started Synedrex yesterday. I pill. With in an hour I was vomiting and had the worst headache ever. Went to the ER. Anyone else have these problems?


I started synedrex but i dont lose my weight in 6 days why

Victoria (Editor)

Hi Karen. Some dieters experienced these side effects as well. If they continue please stop taking the product and consult with your physician.

  I cant sleep
Rosa (Verified User)

I dont have appetite, Is my second days today and I cant sleep, and I feel really bad cause i cant sleep help

Victoria (Editor)

Hi Rosa. If you continue to have these effects, please consult with your physician before continuing to take synedrex.

   eating healthy

Yesterday was my first day an I was lightheaded for about 5 hours an felt really high an jittery it gave me a lot of energy, an then today when I took it I wasn’t as energized an I’ve been having cramps in my leg. Also do you have to work out when on the pill I’ve been eating healthy but don’t have much time to work out????

Victoria (Editor)

Hi Kelsey. For detailed product use instructions please refer to the official synedrex website for more information.

Zee (Verified User)

Been taking it for 3 days, works great on appetite and makes u lose weight. But i am lacking energy all day long while get no sleep at night

Me too also experience 20 second delay urinating.
steve also

My trainer says the same happens to him, me too also experience 20 second delay urinating

  I decided to try this, and it seems to be working!
Curtis (Verified User)

I have been on Synedrex for 2 weeks now. The first day, I had that blood rush to my face deal (red face/ears burning), but it went away within 10 minutes. I have a very sensitive stomach, so I decided to eat before to avoid it. I eat eggs and toast before I take the pill and now I have no blood rush to the face problems. It gives me energy all day. I love it. I lost 20 lbs on OxyElite before they changed the ingredients, 2nd bottle I didn’t lose anything. So I decided to try this, and it seems to be working!

  Can I bring Synedrex from Canada with myself?

Im just wondering if this product is legal to bring into Canada. Im going there next week and want to know if I can bring Synedrex with

   It worked perfect!
Kevin (Verified User)

This stuff works. The side effects of taking one pill were to much. Hot flashes and tremors. My appetite was wiped out all day and had trouble falling asleep. On the 2nd day I carefully opened the capsule and dumped out a 1/3 of the contents, put capsule back together and it was still a little to strong. The 4th day I removed half and took it after lunch. It worked perfect!! No side effects and controlled my appetite until bedtime. I can not fathom how anyone can handle 2 of these pills in a day???

  It works but with side effects.
Unknown (Verified User)

This product is great…but great as it sounds, the last batch that was made is quite alarming when it comes down to the side effects of niacin flush. Calm down! Don’t panic! It will come to pass. If this does happen, get a blanket ready to wrap yourself in, because you will feel the chills later. Drink lots of water to keep the blood pumping. If you want to continue taking this product after having the side effect of niacin flush, I’d suggest taking it every other day, or 1 hour before working out.

Best luck to everyone!

  Has this product been discontinued?
Leslie (Verified User)

Has this product been discontinued?


Yes it has but can still be bought online


Where can I buy it?

Victoria (Editor)

Hi Leslie. For product sales locations, please refer to the synedrex official website for more information.

  I am following Synedrex as suggested.
allison (Verified User)

i would highly suggest doing what i do…waking up an hour before you have to get up and taking your synedrex with a full glass of water, then going back to sleep. i take all of my pills (allergy, thyroid, pepcid) at the same time with my synedrex. when it is time to get up, i’m awake. and moving. then i have a boiled egg…protein…with coffee or water. that keeps your stomach from getting upset and you are asleep when it kicks in.


The Pepcid you take will counter act your thyroid medicine! They need to be taken at separate times!!!!

  Synedrex worked well for me.
allison (Verified User)

i had no problems with the synedrex. i ran out and tried the phenolox and my arms and legs and face tingled and burned. that was the second day. as with anything, one size does not fit all. i’m going back to the synedrex. if you had that reaction with the synedrex, maybe you won’t have that with the phenolox. synedrex worked well for me as i have a thyroid condition, so exhaustion is something i fight against all the time. i take a stacker xpc i get from walmart an hour before i wake up, so i CAN wake up. around noon i take a synedrex. i’m good the rest of the day and not bouncing off the walls. it’s nice for a change.

  I just take my first pill today and was really scared, my whole body turned red and hot, is this normal?
Julieta Garcia (Verified User)

I just take my first pill today and was really scared, my whole body turned red and hot, is this normal? should I take my second pill?


If you take a Tylenol with your Synedrex it will calm the flushing from the Niacin down. That’s what I do whenever I take anything that has niacin in it.


You just need water and to eat before you take it and you shouldnt have the niacin flush. Try to eat thirty minutes before and drink plenty of water and you will be fine. It happened to me and still does occasionally if I do not eat about 30mins before taking it.


That is the niacin flushing your system. It should pass if you keep taking it on a regular basis. Drink plenty of water, not sodas or caffeine drinks. This is one of the best products I have used to curb appetite. It will give you the jitters, and stomach cramps or nausea. Your shedding water, your body is dehydrating. Drink lots of “water”!! I do not recommend taking this more than once a day and more than a two month cycle. If you goal is to lose weight, you will. Is it worth the side effects, you will have to make your own choice. All the symptoms you all are having is the synedrex doing its job.


Julieta, I’m taking Phenolox and the same thing happened to me.

Victoria (Editor)

Hi Julieta. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.

  I did not want to feel like that ever again with them.
Jill (Verified User)

I just took my first pill yesterday and within 20 min my face got hot and bright red and it moved down to my chest. I felt depressed and an emotional all day and was not myself. I had sharp stomach pains and was drinking water all day. It gave me no energy or focus. I just wanted to crawl into a ball and go to bed. I didn’t take a pill today because I did not want to feel like that ever again. Not sure if I will try another pill.


I took my first pill Monday and have been very emotional and depressed. Discontinuing them immediately!


the combination of ingredients happen to mimic the same effects as an amphetamine contained in medications such as the ADD medication Vyvanse. It does cause mood swings, but you can control it after the first couple of days. Just don’t kill yourself. Your body is probably not used to the blood trying to move like a regular athletes, hence why you’re on the diet. It will feel weird the for a while.

  I've bad burning rash with fever and chest pains amd tightening, Has anyone else had this issue?
mica (Verified User)

I have been taking synedrex for about three months and ive been loving it. I finally found a diet pill that works wonders. I recently ran out of pills and ordered a new bottle. I have been taking the new bottle for 3 days now day 2 and 3 I have broken out in a really bad burning rash with fever and chest pains amd tightening..has anyone else had this issue..has anything changed that they put in it. I loved ot and would hate to stop taking it but looks like thats what im going to have to do


Ummm, I take it you didn’t cycle off like you should of


Umm… I just started taking it a week ago for the first time so I haven’t even been taking it long enough to “cycle off like you should” and the sunburnt look and feel happened to me today as well.


I just started my 2nd bottle after great results the first tine and two days in a row I have broken out in a hot red itchy rash on my extremities and now face today….bought from a different retailer this time, but wondering if they changed some ingredient


The same has happened to me I’ve been taking Synadrex for couple years. This new bottle I bought day before yesterday broke me out feeling like a wicked surnburn head, arms, chest this is so weird. I’m wondering if the compound got too much and not enough. I’ve done 30 days of cycling off and 60 days on. This has NEVER happened in over a two year using time. TOO WEIRD…


I have used both Synadrex and Phenolox on 60/off 30 for a couple years and never had any reaction until today. I bought a new bottle of Phenolox and within minutes of taking a pill this morning had the most intense burning and bright red swollen ‘sunburnt’ looking skin. It was awful. It’s somewhat comforting to know this is happening to other people as well. I too LOVE both products but a trip to urgent care is just not worth it.

Victoria (Editor)

Hi Jen. If you continue to have these effects, please consult with your physician before continuing to take synedrex.

  Should I stop taking them? has anyone experience the same side effects?
D (Verified User)

I started taking synedrex a month ago & have experienced the jitters,light headed and nauseas. Other than that, I no longer get sleepy at work & controls my appetite(one a day). However, this wk. I started a new bottle because I had finished the previous one; and notice that for the past two days the side effects are worst. maybe 1/2 an hr. after I take it, my body feels like it is on fire and I break out in this terrible rash around my face, arms, & neck. It is scary… Should I stop taking them? has anyone experience the same thing?


I have had the same thing happen, i am on my 4th bottle, this one causes me break out in a burning rash all over my body, lasts about an hour and then its gone, but it doesnt happen every time i take one its very odd


Same with me. Sometimes the redness, sunburn and heat. Sometimes not. Doesn’t seem to happen if I eat with it or right after. Only when I fast.

Victoria (Editor)

Hello Heather. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.


I bought my first bottle and have been experiencing the same thing! Rash on my face arms and and neck… it doesn’t happen all the time just once in a while and then goes away, but i have stopped taking it after a week of having the experience… What can it be? Just freaked me out a bit….


Got the exact same thing on my second bottle. No idea what it is. Didn’t get it on the first.

Victoria (Editor)

Hello. Some dieters have experienced similar side effects. If you continue to have these effects, please consult with your physician before continuing to take synedrex.

Victoria (Editor)

Hi Allie. For detailed product ingredients please refer to the official synedrex website for more information.

  Same problem, have stop taking the pill, did you go back to your regular sexual activities?
carlos (Verified User)

I have the same problem have you stop taking the pill. did you go back to your regular sexual activities?

  Since I've been using Synederx I have lost my sex drive.has anyone else experienced this?
carlos (Verified User)

I’m 28 male I have always been very sexually active.buT since I’ve been using Synederx I have lost my sex drive.has anyone else experienced this.

Victoria (Editor)

Hi Carlos. If you continue to have these effects, please consult with your physician before continuing to take synedrex.

  Is there anyone who can bring it to me cheaper?
Karim . H (Verified User)

it is my first day with synedrex , i feel fast heart beat and prespiration , btw i buy synedrex from lebanon it cost 100$ , is there anyone who can bring it to me cheaper ???


I buy mine, a 45 pill bottle, from Capitol Nutrition for 45 bucks. My first day was weird, I was wired! So much energy it had me worried. Now that’s not happening anymore but I am still sweating a lot! I’m assuming that’s my body telling me that It’s working!


These kind of pills are not for everyone and there are plenty of em out there! But be careful for imitation of anything! And always do your research. From my personal experience thats how i was too when i first tried these pills. Just make sure u eat after 30 mons of taking them and if you think youre sensitive to them take them every other day then eventually take them once early in the morning. It should say all this on the bottle! As far as buying them $100 is way too much!!! It should only be around 45$-50$!!! Try amazon or the actual synedrex web if they have one! Just be careful -once again!! Do not buy imitation ones


I have been taking synedrex for a week and half. My first week was great nowy second week I feel horrible; sweating heart beating fast

Victoria (Editor)

Hello Karim. For product ordering inquiries or sales locations, please refer to the synedrex official website for more information.

  Crazy side effects but product does work.
Anonymous (Verified User)

I have took 2 cycles of synedrex and am currently on my 3rd every time I take the pills for 6 weeks and I take 2 a day bc strangely enough they make me sleepy not hyper. The issues with getting an erection and size is true. As stated above the caffeine tightens blood vessels and other ingredients that help suppress your appetite have hormonal effects making you want to have sex yet have no sex drive. The effects typically take about 2-3 days of not taking the pills to wear off and for stuff to go back to normal. Lastly the tightening of the blood vessels as well as prostate side effects cause you to feel like you have to be constantly and make you have to push to urinate and make the urine and sometimes you will be done urinating and go to put your member away and you will leak bc you haven’t been able to properly drain all the urine out. Crazy side effects but product does work and no side effects seem to be permanent.

  I'm down 24lbs in 6 weeks!
scott (Verified User)

Yep. Same thing here. Sometimes I can achieve an erection but no orgasm.. very weird. BUT, I’m down 24lbs in 6 weeks! I expect that once I’m off the product things will go back to normal.

yup same here....all the while i thought it was me

yup same here….all the while i thought it was me


No not all I’m going this right now.did you ever stop taking the pills.I stopped about 2 days ago.this is really not worth it. did you go back to yourregular sexual activity? please try to get back to me.I have never had a problem Until now.

  It works for me.
Anonymous (Verified User)

Caffeine causes the blood vessels to tighten. This constriction can prevent the proper flow of blood to the penis when a man is sexually aroused. The effects of – caffeinated drinks and foods, such as coffee, soda and chocolate, can last up to 12 hours. I have been taking Synedrex for about a week and the above holds true until it wears off. But, on the upside I have more stamina and NO problems with performance after the effects wear off! Just my opinion.

  Does it has side effects when start working?
Joy (Verified User)

O.k today was my first day…I threw up , go hot flashes, and cried…..after all that I feel great.no hunger at all. A lot of energy! I am wondering if I can take half. Does anyone know? Thanks !


Ive taken half before and I get the energy without the crazy side effects. Up to a whole pill a day now and after a week my body is finally getting used to it.

Victoria (Editor)

Hi Joy. For detailed product use instructions please refer to the official synedrex website for more information.

  No product is worth that trade off.
B (Verified User)

Ya, exact same issues with erection and size. No product is worth that trade off. I’m done with it.

  Does synedrex increase a womens sex drive?
travis beal

does synedrex increase a womens sex drive


I feel like it does.. It is crazy after I take the pill I so ready to have fun..


I been taking it about 3 weeks.My drive has increased A Whole Lot! I’m down about 10 pounds so I’m a keep using it.

Victoria (Editor)

Hello Travis. The main use for synedrex is, as a thermogenic weight loss supplement.

  It works very well.
Amber (Verified User)

I lost 20 lbs on Oxyelite pro in one bottle, so far on Synedrex a week or so and I’ve lost 8 more lbs! Hopeful to lose 30 more bringing me to 120! It works!!! Watch out for the nausea, dizzness and vomiting whatever you ate before taking it…
LOTS of energy!!!!!!! Drink plenty of water.. has diuretic effects.. very strong, stronger then OxyElite (orig formula)

  This stuff really works.
Patrick (Verified User)

I’ve been taking this for 6 weeks. I was walking 4 miles each morning before I started. In a few days I was walking 6 miles and now up to 10-12 miles each morning. I have so much energy. I started out at 232 and now that I’ve been taking this I’m down to 209. This stuff really works. I have to make myself eat because I don’t have the hunger cravings. I can’t wait to get morning walk done each morning and check my weight.


How long did it take you to get down to 209? And how many calories are you eating a day? I just started taking this. I am on a 1200 calorie diet and exercise 3 days a week. I am also taking it with Thyrene, a non stimulant. Just wondering how long it took you to start experiencing results.

  I'm closer to my goal thanx to this pill.
Dexter (Verified User)

3rd day. N so far I have lost 8lbs. Hunger is gone. But I force myself to eat cuz if I don’t I won’t. Pill has limitless supply of energy.. I feel great.one bad thing is the jitters.. I would recommend this pill to anyone. So far I feel great as far as energy. I weighed myself n it encourages me to run. I’m closer to my goal thanx to this pill. So far nothin is is stoppin me from that goal n this pill is my wingman to that goal..

Try drinking sleepy time tea at night.

Plus..try drinking sleepy time tea at night. It helps bring you down.


I wouldnt mix a upper with a downer…. not very great idea


If you take the synedrex in the morning and drink the sleepy time tea at night it is fine. If you take them at the SAME time it could be a problem.

american soldier

mixing uppers and downers actually doesn’t have that bad of affect, they cancel each other out.

  Does anyone feel like me?
Mellymellz (Verified User)

I have been taking it for 2 weeks, everything’s great but it has me breaking out like I’m going through puberty all over again. Anyone else?

Victoria (Editor)

Hello. All dieters have different results, but please consult with your physician if you continue to have side effects to make sure this product is safe for you to take.

  The product has worked very well though, I have lost 5lbs.
Anonymous (Verified User)

Been taking it for about a week and I have experienced some struggles to get an erection. It seems to shrink my mini me, also not a good bonus! The product has worked very well though, I have lost 5lbs.


I’m having the same issue with erection does this last long or have permanant damage I must know someone tell me something cause the product is working but my penis isn’t up to performance standards


Same problem… also have to push a bit when urinating.

  How much does synedrex cost ?and do u deliver to lebanon ?
joanna lameh

Hey !! i woul like to knw how much does synedrex cost ?and do u deliver to lebanon ?Thank u … im waiting for your reply


There is in Lebanon

Victoria (Editor)

Hi Joanna. Synedrex costs approximately $54.99. For product ordering inquiries or sales locations, please refer to the synedrex official website for more information.

  it does not work.
Berni (Verified User)

Following the directions to take early in the morning was a horrible idea. I vomited throughout the day. I took the second pill after breakfast the following month, hoping that would have made a difference. It didn’t in my case. I should have known better though- I do have acid reflux issues.


I’ve been taking dem for bout. 6 days n I feel lite headed n dizzy wen I wrk out I think I’m not takin them anymore never felt like dis before


I usually take it after eating so that your body has something to burn off while on the pill.


Does anyone know if it’s ok to mix with energy drink with this ?


i drink a cup of coffee midday but i would not mess with an energy drink until about 6 hours, possibly, after you have taken the pill.

Victoria (Editor)

Hello. It is not advised to mix this product with other products containing caffeine.


I had the same vomitting and dizzy experience the 4th day.. I felt too sick to continue.

  I guess it just depends on your caffeine tolorince.
W (Verified User)

This product is amazing. I’ve been taking it for 5 days and lost 16lbs. I’ve been working out twice a day for (cardio in the morning , lift in the afternoon) 45 min and eating healthy. The first day I was a little dehydrated, but after that no problems. I guess it just depends on your caffeine tolorince. Tons of energy and no crash what so ever. I take it every morning at 7:00 and 20 min later I feel like I could run a marathon. My bench has also increased dramatically.

  Will this stuff help me?

I weigh around 136 right now. before I had my children I was118. I would like to get back down to aat least 120. Will this stuff help me? I have been trying to loose weight with diet and exercise but im not getting anywhere.

Victoria (Editor)

Hi Melinda. Since Synedrex is a thermogenic weight loss supplement, you might be able to achieve weight loss by taking this product.

  Love the results.
Katie (Verified User)

I have been taking synedrex on and off for over a year now. I started last feb after I had my baby with oxyelite pro. No results at all. I had a gym friend recommend this and within a week I noticed a big difference. I do work out with it. I eat in the mornings, maybe some egg whites and wheat toast, eat a light lunch, then by the end of the day it’s worn off and I eat again. I am 5’5 and before i got pregant i stayed around 135 – 140.at the end of my pregnancy I was 165 and a year post pregnancy with the help of synedrex I stay around 122. Love the results.


do you ever take it before a workout? i was told you’re not supposed to?

joshua stefanick

it’s great for a preworkout


This stuff is great. I ordered a sample pack of Thyrene, Synedrex, and Phenolox. Each with 2 pills. Basically to see how my body reacted to them. Tried the Thyrene, and nothing. Skipped a day, then tried the Synedrex. Holy crap. I was a hardcore caffeine addict and routine energy drink consumer. I quit the drinks about a month ago when I tried to get serious about dropping baby weight. These pills are insane with the energy, I feel like I have in the past when I had overdosed on caffeine. (it can happen) The amazing part is I have always said I wanted the kind of energy my kids have, and this is it! Also down 4 lbs from yesterday, assuming it was water weight, but happy with it none the less!

  My question is does this supplement help with mental focus as well?
Kourtnee (Verified User)

I just started working out and was recommended to use this to help kick start my metabolism again along with taking protein shakes and of course changing my diet. My question is does this supplement help with mental focus as well?

Victoria (Editor)

Hi Kourtnee. This product is advertised as a thermogenic weight loss supplement, not for mental focus purposes.

  Its working but have side affects.
Arod (Verified User)

Yessss…….. 3rd week 2 pills I cant even eat 6 meals I feel like throwing up and I just feel sick and dizzy… Worst of all I can’t even get hard all way lol…. but It’s working im finally down to 8% bf im finally under 10% I’m 17 so Mabye that’s why I’m having a lot of side affects idk …any advice people? lol


yes, I notice that when I take it my penis is smaller when erect or flaccid, I’m wondering if it’s due to dehydradion from the pill? In any event, I’m going to stop taking it because it does seem to also give me a decrease in stamina and desire.

Victoria (Editor)

Hello. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.

My husband has the same issue.
Anonymous (Verified User)

My husband has the same issue

  I have indigestion all the time. Is this normal?
Kim (Verified User)

I’ve been taking it for over a month and a half and have started feeling like I have indigestion all the time. Is this normal?


I also experience this.

Victoria (Editor)

Hi Kim. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.

  I think Synedrex is great.
Anonymous (Verified User)

I think is great, maybe a little to strong for me, but I lost 3 lbs in 3 days. I love it.

  I did get a very small touch of nausea when working out in the AM.
Jesse (Verified User)

First day I took Synedrex felt like they should have labeled it Thermo-Nuclear. I was go go go. Second day is a lot better, more normal feeling. I did get a very small touch of nausea when working out in the AM. I take it on an empty stomach along with my other supplements, Osteo Biflex, cinnamon, flax seed oil, aleve. I just started working out in the AM instead of PM so it could be anything.


I lost 80 lbs in 36 hrs. works great


80 pounds in 36 hrs?


How many lbs in less than 2 days? I felt hot/sweaty while eating breakfast after taking it and real jittery. That normal. It’s day #1

  Loved the product.
Million (Verified User)

WOW this product had me on point the first day. You will have to remind yourself to eat. And drink water or you will have headaches. Can feel even 9 hours later. Read the reviews made sure I ate something prior to taking the pill. Had B12 shots nothing compares

  Loved the product.
k (Verified User)

whoa- this stuff is basically speed! on 2nd day, and seems to be doing everything it says it will. I take it in morning and feel the biggest rush maybe an hour or 2 later, but effects last all day. I didn’t have trouble sleeping. Yesterday I came home after work and scrubbed my grout with a toothbrush– it’s that kind of high! I think i will only take it a few times a week. Important to drink lots of water. I don’t feel urge to “mindlessly” eat, but i have been eating solid, healthy foods to support my metabolic needs.


Lol me too! I can’t stop moving when I’m on these pills! I just spent 3 hours bleaching and scrubing my house! It’s like speed, but I do feel jittery because I’m not used to caffeine. I don’t drink soda or coffee so my body is on overload. Do you feel lightheaded at all?

  Loved the product.
Jess (Verified User)

Started Synedrex on Monday and decided to take every other day. So, I’m on my fifth day,have only taken 3 pills thus far and am down 4lbs.

I am taking every other morning on an empty stomach. First day was very jittery and could feel the energy tingle out my fingers within the hour of taking. With each pill, the jitters have subsided a bit and by 3rd pill there were no tingly feelings.
I noticed absolutely no hunger pains or cravings the days I take the pill and very little on the days not taking it. I am now very thirsty and drink tons of water.
I have not worked out yet but plan to start doing so next week.


I took it 3 days straight on an empty stomach but I am wondering if I can take one pill every other day and still have the same good results?

Victoria (Editor)

Hi Sue. For detailed product use instructions please refer to the official synedrex website for more information.

  Anyone having side effects?
Jay (Verified User)

I’ve been taking it for abt a month now & I’ve lost 34 lbs. I didn’t get nausea, but I am so thirsty, like I can’t drink enough water. I do an hour cardio 4 times a week. I also notice I have started biting the inside of my jaws n grit my teeth. I didn’t before using the product. ..has anyone else experienced this?


Yes I am the same and I feel so bad.

Victoria (Editor)

Hi Jay. Some users also experienced nausea. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.

  Loved the product.
annie (Verified User)

I have been on synedrex for exactly one week now. So far, I’ve lost 4.5 lbs. I am a fitness instructor on the side and get plenty of cardio in, lift weights as well 2-3 X week. I am amazed at how my body looks! I have a cruise coming up and want to look crazy good in my swimsuit.
I started off with 1/2 a capsule mixed in some juice. Felt awake and ready to go. Definitely get jittery if I don’t eat a little with it. Very strong appetite suppressant, I had to force myself to eat lunch most of this week. I have moved on to one whole capsule within 45 minutes of waking. I do find myself having a hard time falling asleep, but when I do, I’m out!
My day job has me sitting at a desk mostly all day and I have found that now I stand a lot at my desk and move around more because I feel the need to just move.
STAY HYDRATED!!! Make yes to drink lots of fluids or yoi’ll find yourself with headaches and body aches.

  Is it safe to do cardio on it?
Melissa (Verified User)

Is it safe to do cardio on this pill? I took it for the first time today. I went running and it took me nearly an hour just to get my heart rate back down and I had only ran 2 blocks. I also feel a little nauseous, but I know that’s common for the first two days.


i was told its not good to take right before cardio because it constricts your arteries and raised your blood pressure so now im trying to find out if thats right.


I took it today for the first time and went walking for an hour, when I got home I cleaned I started feeling a little nauseous but nothing you cant handle. I drank a protein shake with my pill today and now for lunch I am forcing myself to eat but I am not hungry.
I was taking ripped juice in the morning this stuff is so much more intense!


What kind of Shakes do you take in the morning?

Victoria (Editor)

Hi Melissa. For detailed product use instructions please refer to the official synedrex website for more information.

  Just started will update later.
Raul (Verified User)

HI everyone!! i a new in this, never tried a pill before for losing weight, i’m currently doing p90X, but i want to lose all the fat on my belly and my arms. some recommended this to me, but seeing the comments i dont know!!! i am 30, 235pounds, 6.5ft. i am also having protizime shakes to supply solid food, and very low carb diet. if i take the pills and also the shake, this mix, it is any trouble??? i ve always been a strong person, inmunologycally, but i would like some advices.

  Loved the product.
Rob G (Verified User)

I’ve been taking it for a week now, I have no cravings at all for junk food, for the past week I eat to live , not live to eat, like I have for the past 25 years. This stuff works.

  Loved the product.
Bennie (Verified User)

Just make sure to eat bout 15/30 mins before u take it, I used it for 30/45 days normal workout, the more u sweat the faster u lose it, I went from 204 to 186 n over a month, so yeah its good, but just remember everyone’s body is differant

  Don't take with high BP.

Synedrex is an upper it can have some adverse side effects if you have high blood pressure it can be very hazardous if I remember correctly it even says so on the bottle. In my opinion no I would not take it until I talked to my dr if I was in your situation.

  Any negative sexual effect of it?

Amazing pills. But does it have negative sexual s

  Loved the product.
Anonymous (Verified User)

Im on my second bottle and have been using Hydravax with it. I run and weight train and have noticed a VERY BIG change. I have dropped about 22 pounds from taking both of these products. I have abs and the “ripped” look. I would recommend this product to anyone, in fact I recommended it to several people I work with and they love it!

  16 years old can take it?

Should I be taking this if I’m 16 and an athlete. I want to lose about 15 pounds, does it sound like a good idea?


NO!!!… Learn to eat healthy and continue exercising!!! You are still young and your body is still going through changes! If you eat healthy and exercise, you will lose that 15 pounds!!! You should NOT start teaching yourself that taking diet pills is the answer!!! Make a life change with healthy eating and exercise!!!!

Victoria (Editor)

Hello. Synedrex is not intended for anyone under the age of 18, but please consult with your doctor before taking this product.

  Facing side effects.
Cory (Verified User)

This was my first day taking this . I took it on an empty stomach and within 15 min I was throwing up . That last an hour .. Had to leave work cause I was jittery and sick to my stomach, after 4 hours I was able to come back to work . I still don’t feel good I haven’t been able to eat. I am not jittery anymore just feel under the weather.. I’ml not ready to give up just yet, tomorrow I will try it with some breakfast in my stomach .

  Pills broken. Will it be safe?
Kelly (Verified User)

My pills were in a bag during travel, and some of the pills broke open and have a crack which allows me to see the powder inside that can spill out(if i tried to dump the powder out) Also, they were in the heat and some had melted a little and are softer now, is that okay to still take these pills?

Victoria (Editor)

Hi Kelly. It might be safer for you to just reorder a new batch just in case.

  Loved the product.
Weston (Verified User)

I am 28 years old and in good athletic condition. I work out regularly and have taken a few supplements in the process to help me out. I started using Synedrex last Sunday. It was working great;it gave me plenty of energy and curbed my appetite to where I didnt even get hungry and had to force myself to eat. On the fifth day I started getting horrible nausea and tingling in my extremities especially in my hands and my heart felt like it was constantly beating out of my chest. I used the prescribed dose only one pill a day after breakfast. I never had any trouble until the fifth day. I took it the same way on the sixth and within 3 or 4 hours I was having bad side effects. My pulse was raising from low 80’s to 130’s suddenly and my blood pressure was shooting up at the same time. It would come and go. It got to where I couldn’t breathe and was unable to stand up. I even passed out a few times. I was taken to the emergency room just for to be cautious. Everything is fine now that I am off of it. It worked great in the beginning but unfortunately its not for me. So please just be careful and if you do start feeling any side effects then please stop using it. My situation could have turned out much worse had I not been around people that knew what to do.


exact same reaction here..def not for me..I thought i was dying.. not worth it.


i’m having similar effects. only i get horrible nausea, a little bit of tingling, and i get really hot and dizzy. it helps if i keep cool or get something to eat. i don’t know if its the same issue but its pretty scary.


I had the exact same side effects. I eat before I take it, and I tried taking a day off in between. I stopped taking it, my husband is taking the rest of my supply and hasn’t experienced any of those problems. I think it just isn’t for some people. I am now taking Crash also suggested by my trainer I take it before bed and it helps burn more calories when sleeping, no side effects from this one. I see this is older, did you continue taking and if so did the side effects subside?

Victoria (Editor)

Hi Shanna. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.

  Hated the product.
Alaynah (Verified User)

I took it and wasn’t able to eat for over 24 hours without throwing
Up and woke up almost every hour when I went to bed. Total nightmare

  Facing side effects, what to do?
jessenia (Verified User)

I have 2 days trying synedrex n I feel horrible ….shacky and nerves, what should I do!

  Loved the product.
Ben-e (Verified User)

ive been taking synedrex for a week now, i have lost over 6 pounds tho working out like crazy but i think im not shedding it fast enough do to calories low, my appetite isnt really there

  Loved the product.
cynthia (Verified User)

I have been taking Synedrex for a few weeks and I have lost 8 lbs with no exercise and it does suppress your appetite.I have tried several diet pills and these work for me.

  What are ingredients?

I have a comment and a question. How do you know this product has caffeine in it when it isn’t listed under any of the ingredients? How did you come about this information?


Green tea is caffeine.


LOL Green tea has “very low” amounts of caffeine. methylxanthine is caffeine pal


It has 350mg of Caffeine plus the Green Tea.

  Can u take half a synedrex

Can u take half a synedrex


I do, I just open the cap and transfer 1/2 of the contents into another capsule. one is too strong for me. still works great.


No, idiot.

Victoria (Editor)

Hi. For detailed product instructions please refer to the official synedrex website for more information.

  Facing side effects.
Jazzy (Verified User)

Day 1, not sure if I should keep taking this pill. I am not feeling to great. I am shaky and jittery. Walked around the company like 5 times still not feeling good. Its been 5 hours and now I am nauseaed. I guess this pill is not for everyone.


You have to eat something with it…not just one piece of toast. Big breakfast. Medium lunch. Light dinner.


Yeah, if you don’t eat within 15 minutes you will get really sick. I found that a bowl of oatmeal and a pear worked great. I started this on a Wednesday and by the following Tuesday I had lost 16 lbs while doing a heavy workout ( low reps, high weight) every day. When I began to do an extensive cardio workout daily that also boosted more loss.


I started taking Synedrex 6 days ago and I am down 7 lbs. I’ve gone to the gym 5 days out of the 6. I had severe jitters the first day but then decided to eat first the next day and try it and it made a huge difference. Protein shake with 2 boiled eggs then the pill and the jitters are gone. Hope this helps!

Victoria (Editor)

Hi Jazzy. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.

  Loved the product.
Tony (Verified User)

I am on my 3rd day using synedrex. I take these in the morning before breakfast….maybe 15mins before. The first day was really bad in the sense of jitters and a crazy caffeine overdose feeling, 2nd day better, still pretty strong, though today 6 hours after taking the tablet I feel really light headed and not as motivated as the first 2 days. I didnt have a problem sleeping the last 2 nights.


I took it this morning for the 1st time with a protizyme shake and left walking for an hour and fell great when I got back I started to feel really nautious and have spent whole day in bed, Will I feel better tomorrow?????

Victoria (Editor)

Hi Carmen, some dieters also experienced nausea. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.

  Loved the product.
Jill (Verified User)

I went to the gym on it and I was PUMPED!! I had a great workout.

  Able to lose weight without workout
al (Verified User)

i’m not the type of person to be on a bandwagon, but i been using synedrex for 2 weeks and lost ten pounds without working out looking forward to getting in the gym with it.

  Questions about side effects
eddy (Verified User)

hi , i am using synedrex 15 days ago , but i dont know how to finish from the side effect specially the jitters and insomnia .how can i resolve this issue . and it should be taken before breakfast or after . Thanks a lot


Actually you only take up to two a day I have been using synedrex from about 3weeks and have lost over 20 pounds I only take one pill a day and if you buy from suppliment ware house myou can get it for like 30 for a 45 days supply if you use the price compare to a sketchy website that has a rediculously low price this is my second cycle and I would suggest anyone looking to lose weight use this product also the jitters disappeared after a week or so my rating is a 5/5


I have been on Synedrex for 4 weeks now I have lost only 8 pounds. I eat less than 1,000 calories a day and I walk for about 45 minutes everyday. Other people comment that they have lost over 20 pounds – what I am doing wrong?


i dont think some of yall have tried using syndrex… ive been on it for about 2.5 weeks or so and have lost 15lbs. When you are taking syndrex if you eat more than 1000 calories in a day you feel bloated as crap. I usually only take in around 750 on days I take it and that includes drinking cranberry juice. Seriously, how do yall figure 45 minutes of WALKING is TOO MUCH cardio?!? I go to the gym 4 times a week, lift weights for about 1.5 hours and do 30-45 minutes of running on the eliptical. Lastly, I usually take the pill m-f and take off on the weekends and eat a nice meal on saturday and sunday. This will make you gain a couple lbs from the water your body is now retaining since syndrex eliminates water weight, also will promote speeding up metabolism. So basically I have been losing about 5-7 lbs from m-w then start to level off, gain about 2-3 lbs over the weekend, then 5-7 again m-w so avg around 3-5 loss per week. been working for me so far. ALSO note, weight loss is always going to depend on eating habits, exercise, how overweight you already are or arent. I plan on only taking until I finish the bottle to speed up weight loss to where I want to be and then just maintaining weight.


I’m willing to bet that you’re not doing anything wrong and that your body and synedrex don’t cooperate with each other.

Juan Pla

Not enough food, too much cardio, and not enough emphasis on weight training. You need to sit with a professional to figure out your specific caloric needs as well as the proper training program for your goals. Blind caloric recommendations will not do.


Eat more you should be at approx 1800 calories a day.
By eating clean a proper diet will increase your metabolism. 5 meals a day. Pills will only give you a slight advantage. Keep up your workouts. Weight loss occurs over months. Don’t get discouraged.


you are not eating enough, your body is in survival mode and will not let go of fat stores.


Wow, Alan. Kinda harsh.
It is true though, eating less calories wont promote weight loss. I have been on Synedrex for 2 bottles now, with a month break in between and I have had great results. Eat well, keep walking. You need good calories, that’s it. Keep at it. It takes 4 weeks to notice a dfference in yourself, 8 weeks for your spouse to notice and 12 for your friends to notice. Keep it up!

Alan Arguello

You’re slowing your metabolism down to shit. Eat 1500 calories a day, evenly over 8 hours and take in no solid food after 6PM. Ephasize lean protiens, leafy greens, and health fats and you’ll shed it. If you want abs stay away from a.b.s. Alchohol. Bread. Sugar

Victoria (Editor)

Hi Sue. All dieters have different weight loss results. Some users loose weight faster/slower than others.


Im in my third day, but i had a question. Do you have to take it everyday or just the days you go to the gym? because i was planning on taking it only on gym days…


I would take it everyday, but after two months of taking it take a month to two month break from taking it at all.

That way you keep your body guessing, but keep going to the gym regular schedule and keep your diet the same. DIET DIET DIET. It’s not just the pill doing the job for you. ITS YOU!

My trainer recommended this product to me, and it’s a great product!

Victoria (Editor)

Hi Eddy. This is a common side effect for some dieters. If you continue to have these side effects, please consult with your physician before continuing to take synedrex.