I have to make a confession: I was obsessed with researching Relacore, so we created an in-depth review, examining the side effects, ingredients, and clinical studies. We additionally scrutinized hundreds of dieter comments and reviews posted all over the web. At this point, we condensed everything we found to give you the facts you need.
What is Relacore?
First off, Relacore is a “feel good” pill for weight-loss, which is supposed to ease stress so cortisol levels lower and belly fat decreases. You’ll take three capsules per day. The supplement is meant to help improve mood, lower anxiety,  boost energy and fight fatigue. The ingredients include B vitamins, passion flower, magnolia bark, Chinese skullcap root, Asian ginseng,  poria extract, phosphatidylserine, perilla leaf and jujube fruit. The bottle is small enough that you’ll have no trouble taking it on-the-go.
Relacore has been around since 2000. The Carter-Reed Company makes it and has a good BBB rating. The official website provides a 100% money-back guarantee, and it contains a few natural ingredients, but read on…
Lack of Results – “Worrisome?”
Our first problem with Relacore ingredients is that results mirror what you’d expect from clinical research – no change in weight-loss or energy, in some cases. ”We took a close look at the company website, and it’s clear that no scientific studies are presented. There is simply a lot of hype about this supplement, weight-loss and stress reduction,” said our Research Editor.
One customer said, “I purchased Relacore to reduce belly fat, which it did not do.” Shrinking abdominal fat is important to overall health. 
Another stated, “This product was a disappointment. Not only does it taste bad, I felt or saw no results after taking for a month as directed.”
There’s no doubt negative reviews are out there, but what about positive ones? One customer said, “So maybe I am buying expensive vitamins, but it works. Before I tried this I was hungry all the time.”
Relacore Side Effects – “Watch Out!”
Some dieters are experiencing Relacore side effects, which is not unheard of based on research into certain ingredients.  One customer said, “I experienced flu like symptoms. I stopped taking them and the very next day I felt right as rain.”
“I took this product a total of one day! It made my heart race and I didn’t even take the whole dosage,” said another user.
Not everyone felt the same. A customer said, “Gonna give it another try…No side effects!”
Another saw no negative reactions, “No unpleasant side effects.”
The research we have conducted has shown that if an aspect of a diet formula concerns, like adverse reactions, the chances of success are not good. In other words, if Relacore supplements do cause side effects, this could, in fact, be a big problem.
The Science – “Legit?”
Unfortunately, similar to a product like Serovital, the company does not provide reliable clinical evidence to support these weight-loss supplements. We were unable to locate any clinical or medical support that backs promises of reduced stress or abdominal fat. It is important to reduce belly fat not only as part of weight-loss, but as a part of a total wellness plan. We at DietSpotlight need to see published scientific research that supports the diet product and the ingredients it contains. If there is none provided, we become very concerned.Also: read our Dietspotlight Burn Weight-Loss Kit review »
The Bottom Line – Does Relacore Work?
Alright, is now the time to run out the door for Relacore? Is it one of the belly fat pills that really work? We like that the business has been around for years and that it contains a few natural ingredients, but we have concerns about supporting a supplement that is not clinically proven to promote weight-loss. Moreover, some customers have complained of side effects and lack of results, similar to issues with products like Hydroxycut and It Works.
Dieters that wish to lose weight and get fit faster may want to try a weight-loss supplement that is backed by plenty of positive customer reviews and documented clinical research. Remember, there are no belly fat pills that really work.
Among the best products we’ve seen this year is a product called Dietspotlight Burn. It contains a proprietary blend of four ingredients that, based on our research and published clinical studies, have been shown to help boost metabolism, jump-start fat loss and decrease hunger. We also found that user testimonials all over the web paint an impressive picture of results.
Furthermore, Dietspotlight Burn’s makers are so confident that you’ll love their supplement that they’re offering a Special Trial Offer, which is quite the positive sign.
Previous Relacore Review (Updated July 24, 2014):
Relacore - What You Should KnowRelacore is a diet pill that aims to assist users with losing weight. It claims to be one of the belly fat pills that really works. This product is also known as the "belly fat pill." The reason for this is that Relacore supposedly addresses the dieter's belly specifically. Relacore is claimed to improve mood while reducing stress. Unfortunately, the FDA has some opposition with this claim. This diet supplement is intended to be taken in conjunction with a healthy diet and regular fitness regimen if the user intends to decrease excess belly fat. The official Relacore website states that most individuals who take Relacore see stress relief and mood improvement within a few days. In short, the Relacore website discusses the correlation between weight gain in the stomach region and stress. Therefore this diet supplement aims to minimize stress levels in order to live up to the claim of being one of the belly fat pills that really work. Relacore is claimed to contain all-natural ingredients, but apparently, should not be taken by women who are pregnant. This diet pill does not specify any particular active ingredients, which may address stress relief or cortisol. Relacore goes into a bit more detail on its official site. Relacore is to be taken daily, but there is also a nighttime version of Relacore called Relacore PM, which is taken immediately before bedtime. A single bottle of Relacore contains 90 pills and costs $49.95 via the official website, while a single container of Relacore PM sells for $29.99 and contains 60 pills. Almost as much as Venus Factor. The Relacore website claims that this product is free of all stimulants.
List of IngredientsNo list found.
Product Features of RelacoreRelacore is basically a diet pill that is geared toward women specifically to address "belly fat" issues. This drug is claimed to be all-natural and aims to improve the user's mood, while reducing stress levels. Relacore does not contain any specific key ingredients. The Relacore Ingredients goes into more depth on this. This diet supplement is intended to be taken daily with a healthy diet and regular exercise in order to assist with the reduction of belly fat. A 90-count container of Relacore sells on the official website for $49.95. Relacore is available without a prescription.
- Relacore can be purchased conveniently through the official website.
- Relacore comes in a simple pill form.
- Relacore is stated to contain only natural ingredients.
- The official website claims that Relacore is free of any stimulants.
- Relacore does not appear to be FDA approved.
- No key ingredients are specified for Relacore.
- There is no manufacturer guarantee from the makers of Relacore.
- The official Relacore website lacks a complete ingredient list.
- The website fails to provide free trial samples of Relacore.
- Some individuals may be allergic to certain ingredients found in Relacore.
- May cause nausea. (See Relacore Side Effects.)
- No money-back guarantee is offered on the official website.
Relacore ConclusionThe notion of a diet pill like Relacore, which is claimed to improve mood and reduce overall stress levels is intriguing. We like that the company has a good standing with the BBB. Unfortunately the official website fails to provide substantial information on the drug. With no specified active ingredient or ingredients at all for that matter, Relacore may raise a few eyebrows. Another similar product that lacks significant amount of clinical studies is Force Factor. Products with ingredients like Meratrim, that have clinical studies behind them, are the products to look for when trying to achieve your weight loss goals. Furthermore Relacore is stated to be all-natural, yet it remains a mystery what is actually in the product. On the bright side Relacore is stimulant free, but as a dieter it's wise to consult a physician prior to testing a diet supplement such as Relacore. Especially since it's not approved by the FDA like some other diet supplements on the market today.
Relacore is the "belly fat" pill that's marketed heavily in television and radio ads. There are multiple supplements, but Original Relacore, Relacore Extra, Relacore Max and Relacore Fat Burner make up the base of the weight-loss line. Stimulants are part of some formulas, but others rely on the Relacortin Plus blend for results.
Relacore Ingredients and Supplement Facts
Serving Per Container: 30
|Amount per Serving||% DV|
|Relacortin Plus Proprietay Blend||240mg||*|
|- Passionflower Powder||*||*|
|- Magnolia Bark||*||*|
|- Chinese Skullcap||*||*|
|- Asian Ginseng||*||*|
|- Poria Sclerotum Extract||*||*|
|- Jujube Extract||*||*|
|- Perilla Extract||*||*|
Other Ingredients: None
We dug deep into the Relacore ingredients to give you the information you’re looking for.
Also known as panax ginseng, this plant grows in Korea and parts of China and Siberia. The root is used as medicine. It should not be confused with American or Siberian ginseng.
What is it Supposed to Do?
According to WebMD, panax ginseng is supposed to improve thinking, memory, concentration, and physical stamina. It may also prevent muscle damage as a result of exercise, and increase athletic endurance.
According to a study published in Phytomedicine, “[We] observed anti-diabetic and anti-obesity effects of Panax ginseng berry in adult C57BL/Ks db/db mice and their lean littermates.” It is not known whether the same effects would happen in humans. 
Passionflower is a plant. The above ground parts are used to make medicine. The extract is used as flavoring in food and beverages.
What is it Supposed to Do?
Passionflower is typically used for insomnia, stomach upset related to anxiety, generalized anxiety disorder (GAD), and symptoms related to narcotic drug withdrawal. It has also been used for seizures, hysteria, symptoms of menopause, and pain relief.
A study published in Fitoerapia showed that when used with St. John’s wort, has “anti-depressive therapeutic effects of Hypericum [St. John’s wort] are possible with lower doses, when it is combined with Passiflora [passionflower], than with mono-preparations of Hypericum.”  Basically, using passionflower enhances the effects of St. John’s wort.
This fruit is known as the Chinese date or red date. It is a component of Chinese medicine.
What is it Supposed to Do?
The fruit is high in antioxidants, and as such is used for cancer treatment, anxiety and insomnia, liver protection, weight control, clearing the skin, purifying the blood, and providing stress relief, based on alternative medicine.
While several clinical studies are available on jujube fruit, they appear to apply to how to the fruit is handled, stored, and preserved. We were unable to find studies to demonstrate the effectiveness for any of the above suggested treatments.
Magnolia is a plant. The bark and flower buds are used to make medicine.
What is it Supposed to Do?
Magnolia is used for weight-loss, digestive problems, constipation, anxiety, depression, stress, fever, headache, stroke, asthma, and inflammation.
Chinese Skullcap Root
Chinese skullcap is a plant. The root is used to make medicine.
What is it Supposed to Do?
The root can be used to treat respiratory infection, fever, and hay fever. It may also help with gastrointestinal infection and liver problems.
Poria extract comes from poria mushroom. The filaments are used for medicine.
What is it Supposed to Do?
Poria extract is sometimes used for amnesia, anxiety, stomach problems, diarrhea, urination problems, sleep problems, and fluid retention.
Perilla is an herb. The seeds and leaves are used to make medicine.
What is it Supposed to Do?
Perilla has been used in alternative medicine to treat asthma, nausea, muscle spasms, and sunstroke. It induces sweating.
Among the best products that has graced our presence this year, Dietspotlight Burn has four salient ingredients proven in studies that helps ignite the metabolism and hasten weight loss. Consumers have raved about this fat loss supplement’s remarkable results.
We’ve looked at Relacore, but we felt this one needed a bit more attention, so we dove into Relacore ingredients. The clinical research was viewed to see if this product is worth a try. We also scoured hundreds of dieter comments for information on personal experiences. Then, we collected the info to give you the bottom line.
What You Need to Know
Relacore is the “belly fat” pill that contains passion flower, Chinese skullcap root, magnolia bark, Asian ginseng, phosphatidylserine, poria, perilla leaf and jujube fruit. If you take two tablets, three times a day, it is supposed to improve mood and fight abdominal weight. If you need to take the bottle with you, it is small enough that it won’t give you problems.
The product, offered up by the Carter-Reed around 2000, contains all natural extracts and vitamins, a step in the right direction. You’ll have no trouble finding the weight-loss supplement in stores and online. We like that some dieters have reported pretty good results and the company has a strong BBB rating, but read on…
The first thing we took into consideration about Relacore ingredients was the potential for side effects. “You choose to give a weight-loss supplement a try because the product claims have convinced you it will work,” says our Research Editor. “The trouble starts when you feel worse after taking it.”
“I noticed that my tummy was getting fat. I was always bloated. At times, I was nauseous and dizzy,” offers a dieter who experienced Relacore side effects.
“This product gave me bad heartburn. I took as directed, and if it worked I would have overlooked the heartburn,” explains another customer.
If customers purchased Relacore between January, 2000 and November, 2014, a class-action lawsuit settlement offered cash compensation for up to two bottles per household. The issue with Carter-Reed stemmed from mislabeling the supplement. The label claimed weight-loss and mood improvement as benefits, but these statements were not supported by clinical research, according to dieters.
Ineffective – “Not Your Best Option!”
We also found that dieters believe Relacore ingredients are just not effective. “I didn’t really notice much of anything with this product. It didn’t change my mood at all, it also didn’t help with stress or sleeping,” experienced one customer.
“I really haven’t noted that this product has delivered any results,” offers another.
We found multiple reports of the same problem, “I was hoping I would get the results promised…But I didn’t loose any weight…I walk 3 miles everyday and was hoping I would slim down as promised…..But nothing happened…”
Based on our research, it can take something small, like side effects, to lessen chances of long-term weight-loss success. If Relacore ingredients don’t live up to dieter expectations, they will take their money elsewhere.
There are no clinical studies available to support weight-loss claims made about Relacore ingredients. This is one reason for the lawsuit, though Carter-Reed says the settlement does not mean they have done anything wrong. At DietSpotlight, we need science to help us sort out the good products from the bad. If there’s no research, there’s no reason to buy.
The Bottom Line
Our look into Relacore ingredients gave us a better view of the supplement. We like that the formula is all-natural and the BBB rating for Carter-Reed is good, but we can’t recommend a product that’s not supported by clinical research. We’re also concerned about dieter reports of ineffectiveness and side effects.
If it’s your time to lose weight, we suggest trying out a supplement that does offer proven ingredients and a formula that’s not associated with side effects.
Among the best supplements we’ve looked at this year is Dietspotlight Burn. Our research revealed a four-ingredient proprietary blend that’s clinically studied and backed by published studies showing it helps ignite metabolism and fat loss. Dieters have reported no harmful side effects, but they are talking about the good results they’re seeing from the product.
Also, the company that makes Dietspotlight Burn is confident in the supplement so they’re offering a Special Trial Offer, nice touch.
- 1. Ginseng berry reduces blood glucose and body weight in db/db mice (2002). Phytomedicine. October 5, 2016.
- 2. Pharmacological studies in an herbal drug combination of St. John's Wort (Hypericum perforatum) and passion flower (Passiflora incarnata): In vitro and in vivo evidence of synergy between Hypericum and Passiflora in antidepressant pharmacological models (2011). Fitoterapia. October 10, 2016.
Relacore Side Effects:
In a world seemingly dominated by natural weight-loss supplements, it’s important to remember that natural alternatives don’t always mean you won’t notice an irritating change or two. There is always a potential for a negative reaction with any kind of formula. Although, Relacore side effects are unlikely, that doesn’t mean they aren’t a reality for some people.
Heartburn is a type of indigestion where the chest experiences a burning sensation. This pain is often mistaken for heart issues due to the similarity in symptoms.
What causes heartburn?
Heartburn is caused when stomach acid seeps or refluxes into the esophagus. This occurs when a muscular valve called the lower esophageal sphincter (LES) opens too often or fails to close as tight as it should. Often times too much food in the stomach or too much pressure on the stomach will cause heartburn, as well as certain acidic foods. 
Lethargy (also known as fatigue), can cause a sluggish feeling or state of constant sleepiness. This can affect your body physically and mentally.
What causes lethargy?
Lethargy can be brought on by many acute illnesses as well as mental health conditions. It can also be a side effect of certain medications. Sleep apnea can be a factor in lethargy, as well as hyperthyroidism, depression, or poor diet.
Headaches (also known as cephalgia), is a pain in the neck and head region, often categorized as primary and secondary. These types of headaches, although different, can each range from mild to severe pain.
What causes headache?
Primary headaches are caused by pain-sensitive elements in the head like blood vessels, muscles, and nerves. Some examples of these would be migraines and tension. Secondary headaches are classified as pain stemming from another source, such as dehydration or anxiety. 
Nausea is the sick and woozy feeling in the stomach accompanied by the urge to vomit. Although this symptom typically precedes vomiting, it doesn’t always mean vomiting will occur.
What causes nausea?
Nausea can happen when a part of the brain, called area postrema, detects harmful toxins. This area communicates to the brain to initiate vomiting in an effort to rid the toxins from the body. Motion sickness, dizziness, certain medications and parasites could also be a factor.
Relacore side effects are unusual, but there have been reports of negative effects, some of which include heartburn, lethargy, and headache. In an effort to shield yourself from any potentially issues, it’s always wise to consult a doctor before taking any supplement, especially if you are under the age of 18, have any sort of medical condition, pregnant or nursing, or taking prescription medications.
Relacore is designed to fight stress and thus impact weight gain associated with it. Though the ingredients, and this supplement, are rarely connected with side effects, we did find a few here and there.
“Just makes you jittery like all crappy off the counter stuff.” Candy
“I was always bloated. At times, I was nauseous and dizzy. I could not fit into my skinny jeans.” Elizabeth
“Aches, headaches and sinus congestion. I thought I was losing my mind, but I stopped taking them.” Kim
“It made my heart race, my throat burn and I felt so sick and I didn’t even take the whole dosage.” Sue
“I began to have horrible bladder trouble, shaky feeling just sick all the time, so when I ran out and couldn’t get any I went in to like withdrawals it was a nightmare, no sleep for over a week, weak no energy.” Patti
“This product gave me bad heartburn. I took as directed.” Bre
“I was more tired than ever, and my daughter reported that I was extremely crabby as well.” Mimi
“I took one pill and it made me sleepy all day and at night kept me awake.” Lynn
“Relacore broke my face out within two days of taking it.” Kimmy
“After taking this product for about 3 weeks, I started noticing a sudden change in my hair. My hair became dry, breaking, falling out from the root.” Mel
“I was taking Relacore… and I experienced diarrhea…so I quit taking it.” Sandy
The hassle with giving weight loss supplements a try is roughly the amount of time taken to see results. With a product like Dietspotlight Burn there are no negative side effects, and consumers have raved about their health improving and astounding weight loss results.
We’ve heard the buzz surrounding Relacore, so in this review we concentrated on Relacore side effects. We look closely at the ingredients and clinical research. We pay close attention to customer comments and reviews relating to how the product affects dieters. We then condensed the info to give you the bottom line.
What You Need to Know
To start, Relacore ingredients include jujube fruit, perilla leaf, phosphatidylserine, poria extract, Asian ginseng, Chinese skullcap root, magnolia bark, passion flower extract and B-vitamins. According to the label, customers take two capsules per day, which supposedly results in weight-loss. One of the benefits was the small size of the pill.
The supplement was introduced as a stress reliever and belly fat reducer by Carter-Reed in 2000. Customers can shop for the product on the official website and through outside retailers. We like that the company has a favorable BBB rating and a strong foothold in the industry, but read on…
The first concern noted about Relacore side effects is stomach issues. “You take new supplement that promises to spark weight-loss, but then something happens,” said our Research Editor. “Instead of feeling better, suddenly you don’t feel so hot.”
“Tell this product does not work. It makes you have lemon yellow urine and your belly to blot, making your belly even fatter,” commented a dieter.
“I began to have horrible bladder trouble, shaky feeling just sick all the time. No sleep for over a week, weak no energy,” said a customer.
“The only thing I noticed with it was stomach upset. From the second day I took it until the day after I finished taking the last capsule,” explains a consumer.
In 2014, a lawsuit was filed against Carter-Reed because of false advertisements. The complaint alleges that the company mislead customers into believing the supplement would work. As of April 2015, the matter was still being addressed by the court.
Carter-Reed was cited by the FDA in 2004 for advertising Relacore as a medication. Since the formula was not tested and approved, the company was given a chance to remove the statements. Changes have been made to the official website and marketing material.
After reviewing customer comments, we noticed Relacore side effects included increased heart rate. “It made my heart race, my throat burn and I felt so sick and I didn’t even take the whole dosage,” commented a user.
“I took this product for 4 days as it says on the bottle. I ended up in the emergency room with very high blood pressure. My blood pressure was through the roof,” reported a dieter.
I took one dose of it. That was all. It made me so jittery that I could barely function. It my heart race, my pulse quicken and really kind of scared me,” said a consumer.
Our research has found if any part of a supplement is a concern, like racing heart, you could see diminished long-term success. If Relacore side effects are as dieters explain, users will walk away.
Based upon the information available on the Relacore website, the company makes the case that the supplement is effective, but we couldn’t located published clinical research supporting the statements. Even the FDA concludes there’s, “no information that your products are generally recognized as safe and effective” based on federal guidelines. We at DietSpotlight concentrate on fact-finding and science in order to support weight-loss claims. If there are no studies, that’s a problem.
The Bottom Line
After taking an in-depth look at Relacore side effects, we’ve reached a conclusion. There are some positives, like the time the company has been in business and the favorable BBB rating, but we can’t recommend it because of the lack of published clinical research associated with weight-loss claims. Plus, we’re concerned that the reactions could become an issue.
If you’d like to shed some pounds, we suggest a supplement with no side effects that’s supported by published scientific studies.
Dietspotlight Burn is one of the best supplement we’ve come across this year. The four-ingredient proprietary blend, has been shown in clinical studies to jump-start metabolism and increase fat loss. There’s no one talking about negative side effects and dieter reviews show people are seeing amazing results.
The company that makes Dietspotlight Burn is confident in the supplement so they’re offering a Special Trial Offer, a positive sign.
Relacore Questions & Answers:
We boiled down hundreds of user comments about the Relacore belly fat pill into this helpful FAQ.
What are the side effects of Relacore belly fat pill?
Relacore side effects may include increased heart rate, nausea and headaches, according to customer reviews we read.
What is in Relacore belly fat pill?
Relacore ingredients are passion flower, Chinese skullcap, magnolia bark, poria extract, perilla leaf, Asian ginseng and jujube fruit.
What is the active ingredient in Relacore diet pills?
The active ingredient in the Relacore belly fat pill is a proprietary blend of extracts.
Does Relacore work – is it one of the belly fat pills that really work?
We checked the Relacore website to see if any clinical research was listed, but none was. The focus of the supplement is reducing stress to fight belly bulge.  There’s mention of clinical proof, but we were unable to find any.
How much does a bottle of Relacore diet pills cost?
A bottle of Relacore costs about $16. You get 72 tablets and you take three per serving. That means a single bottle will only last 24 days. A one-month supply will cost about $20.
How do you take Relacore diet pills?
You should take three tablets first thing in the morning. If you buy the weight-loss kit that includes the Relacore fat burner, there is an additional pill to take during the day.
What do users like about Relacore diet pills?
Some users like that they experienced improved mood  and increased energy when taking Relacore. The price is also a positive, according to reviews.
What do users NOT like about Relacore diet pills?
The most common issue we found with Relacore, based on reviews, was side effects like nausea and headaches. It is also concerning that many dieters report seeing no boost in weight-loss.
Is Relacore belly fat pill really #1?
The official website says Relacore is “Americas #1 Selling Belly Fat Pill.” We know the claims have not been evaluated by the FDA and there’s no proof to back this up, so we’re not sure if the company is telling the truth or not. We do know the supplement is marketed to curb belly fat, which means it may not be the #1 fat burner, weight-loss supplement, appetite suppressant or one of many other categories.
Is Relacore for stress, aging or belly fat?
This is a little confusing. Relacore claims to fight stress, which is related to abdominal fat and premature aging. There are studies mentioned on the official website, pertaining to the latter, but none support the supplement. Basically, according to the company, the formula is supposed to fight stress and when that is lower the rest of the benefits come along.
Who makes Relacore belly fat pill?
Relacore is made by The Carter-Reed Company.
When looking for a weight loss supplement, it’s best to choose one that’s packed with ingredients for burning fat, increasing energy levels and accelerating the speed of the metabolism. One that fits all these criteria is Dietspotlight Burn.
- 1. Psychological and metabolic stress: a recipe for accelerated cellular aging? (2009). Hormones (Athens). April 8, 2016.
- 2. Vitamin supplementation for 1 year improves mood. (1995). Neuropsychobiology. October 5, 2016.
Relacore Scientific Abstracts:
It was found that oxazepam and Passiflora extract (passionflower) had been effective in treating generalized anxiety disorder. At the end of the trial, there had been no substantial difference between the two protocols, oxazepam showing a quick onset of action. Participants on oxazepam experienced significant impairment in job performance. It was concluded that Passiflora extract is a useful tool for managing generalized anxiety disorder with a low rate of impairment of job performance. 
Either Magnolia bioactive constituent 4-O-methylhonokiol (MH) or Magnolia officinalis extract BL153 (BL153) inhibited body weight gain of mice, in small amounts, by high-fat diet feeding. The epididymal white adipose tissue weight and body fat mass were both slightly decreased by MH or BL153. Magnolia significantly decreased high-fat-diet-induced plasma triglyceride, hepatic triglyceride level, the activity of alanine transaminase (ALT), liver weight, cholesterol levels, and ameliorated hepatic steatosis. Also, the infiltration of mast cells in adipose tissue was reduced in BL153 or MH treatments, respectively. The results had suggested MH, the Magnolia bioactive, may show potential benefits for high-fat diet induced obesity by improving insulin resistance and lipid metabolism. 
Poria Sclerotum Extract
Results of this study have indicated that ethanol extract of P. cocos (EEPC) displays potent inhibitory effects on nitric oxide (NO) production as well as slowing prostaglandin E2 (PGE2) release in lipopolysaccharide (LPS)-induced macrophages with no effect on cell viability. Additionally, EEPC substantially attenuated lipopolysaccharide-induced secretion of inflammatory cytokines IL-1β and TNF-α. LPS-induced expression of nitric oxide synthase, cyclooxygenase (COX)-2, IL-1β, and TNF-α, had been reduced by pre-treatment with ethanol extract of P. cocos at the transcriptional level. In conclusion, when taken together, the data shows that ethanol extract of P. cocos targets the inflammatory response of macrophages through the inhibition of COX-2, iNOS, IL-1β and TNF-α via the disabling of the NF-KB signaling pathway, thus backing up the pharmacological basis of P. cocos as an herbal medication in which could treat inflammation and its associated disorders. 
Gastrointestinal symptoms in participants significantly improved over a duration of time by Perilla frutescens extract in the intervention phase (bloating: -0.44±0.56, p=0.0003; gas passage: -0.30±0.66, p=0.0264; gastrointestinal rumbling: -0.55±0.87, p=0.0014; sensation of feeling full: -0.36±0.72, p=0.0152; discomfort in the abdomen: -0.54±0.75, p=0.004), as opposed to the placebo group which only experienced abdominal discomfort improvement (-0.31±0.55, p=0.0345). In conclusion, the effects that had been demonstrated during testing of Perilla frutescens extract to improve GI complaints offer some highly positive results. 
- 1. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam (2001). Clinical Pharmacy and Therapeutics. October 20, 2016.
- 2. The Magnolia Bioactive Constituent 4-O-Methylhonokiol Protects against High-Fat Diet-Induced Obesity and Systemic Insulin Resistance in Mice (2014). Oxidative Medicine and Cellular Longevity. October 20, 2016.
- 3. Ethanol extract of Poria cocos reduces the production of inflammatory mediators by suppressing the NF-kappaB signaling pathway in lipopolysaccharide-stimulated RAW 264.7 macrophages (2013). BMC Complimentary and Alternative Medicine. October 20, 2016.
- 4. Perilla extract improves gastrointestinal discomfort in a randomized placebo controlled double blind human pilot study (2014). Europe PMC. October 20, 2016.