This last week, I decided that now was the time to find out more about Alli. We dug through the ingredients, side effects, customer service reports and even clinical studies. Then, we looked around the web for reviews on the product. Finally, we refined and condensed to give you the bottom line.
What is Alli?
First off, Alli is a lipase inhibitor.  The active ingredient is orlistat.  If you take one pill with each meal, it supposedly reduces the amount of fat absorbed and blocks about 25% of the fat you eat.  That equates to about 100 calories a day. The bottle is small, and there is an easy carry container in some starter kits.
Alli is made by GlaxoSmithKline, which was founded in 2000. You can purchase supplement at local grocery stores and through trusted retailers. We like that the product is FDA-approved  and there are reports of weight-loss, but read on…
Alli Side Effects – “Worth It?”
The first negative relating to Alli side effects was the intensity. “If you take the medication regularly you can expect less fat to be absorbed, but there’s a catch,” said our Research Editor. “If you eat too much fat, you may have to deal with gastrointestinal issues.” 
“I have experienced one accident with a BM,” one user said. “I really have to watch what I eat or I will pay for it later.”
Another offered, “I have had a rough time with not being able to be too far from a rest room.”
Not all users had the same problems. Some, as a matter of fact, ate high-fat meals and experienced no side effects. “I decided I would eat a fatty meal to test the effectiveness so I got a fast food combo, came home, took a pill, then ate. Nothing happened. No side effects, nothing,” according to one user.
“I found that the only side effect was my systolic and diastolic levels were reduced,” commented another. 
Cost – “A Bit High”
Another issue we found dieters did not like about Alli ingredients was the cost. “This has absolutely no effect on me whatsoever and I have the most sensitive stomach of all the people I know. Waste of $60,” said a customer.
“Not as much weight as I’d like to have lost for a $150 cost, at this point, four months in,” was one experience.
There are some dieters who felt the money was well spent, “You will see faster results such as lowered ldl cholesterol  if you include exercise and vitamins. Worth the price.”
We’ve found that over the years there’s been a logical connection between small things, like side effects and a lesser chance of long-term results. If Alli causes adverse reactions, that could be enough to scare dieters away.
The Science – “Any Clinical Proof?”
Unlike many other weight-loss solutions on the market, Alli is clinically proven to work. However, at the maximum amount of fat grams, you will reduce calories by about 100. The real key is eating a healthy diet and exercising while using the supplement. . There’s also the chances of negative side effects affecting the functionality of the bowel system and intestines.  At DietSpotlight, we think science should do more than proving you have to cut fat or suffer the consequences.Also: read our Dietspotlight Burn Weight-Loss Kit review »
The Bottom Line – Does Alli Work?
Are we running out to the store right this minute for Alli? Well, we certainly like the fact that the FDA has approved the medication and there’s no doubt it can block up to 100 calories a day, but we’re hesitant about recommending it because of the risk of side effects. Bowel leakage  is an extremely embarrassing situation, and we’re not sure it’s worth it when there are clinically proven options with no adverse reactions.
If you want to get off that extra fat, we suggest going with a product that’s been tested and proven to help you reach your goals without risking the embarrassment of some gastrointestinal side effects.
Among the best products we’ve seen this year is our supplement called Dietspotlight Burn. This formula contains four ingredients. All clinically-tested with results often seen in publications such as the Journal of Medicine and the journal Obesity.
Plus, we’re so confident that you’ll love our supplement that we’re offering a Special Trial Offer, which is a good sign.
Previous Alli Review (Updated September 20, 2012):
Alli - What You Should Know
Alli is a diet supplement that endeavors to assist with weight loss. This product was developed and manufactured by the major pharmaceutical company GlaxoSmithKline. The Alli diet pill is stated to be FDA approved and is commonly available without a doctor's prescription. The official Alli website addresses the supplement as an "anti-obesity wonder drug." It additionally discusses the "65 percent" of American adults that are currently overweight. Alli diet pills can be purchased through the official website for $44.99 for a 60 capsule starter container. Alli is claimed to be more effective when taken in conjunction with a healthy diet and regular exercise regimen. Alongside a healthy diet and exercise, Hydroxycut is a thermogenic for men and women to boost the metabolism, increase energy levels and assist with weight loss.
The key active ingredient found in Alli supplements is called Xenical (or Orlistat), which is a prescription weight loss drug. This diet pill aims to minimize the body's fat absorption or block a good 25 percent of fat that's consumed. Some potential side effects that can occur are a vitamin deficiency, "loose stool" and excessive gas (flatulence). Alli can be purchased in most common drugstores and superstores across the US. This diet supplement is claimed to alter the process of triglycerides being broken down inside the body by obstructing an enzyme, which is found in the pancreas. This process prevents fat absorption. The Alli Diet Pill is marketed toward both men and women who are suffering from obesity and other individuals who are borderline obese.
List of Ingredients in Alli
Orlistat 60mg, FD&C Blue 2, Edible Ink, Gelatin, Iron Oxide, microcrystalline cellulose, Povidone, Sodium Lauryl Sulfate, sodium starch glycolate, Talc and Titanium Dioxide.
Alli is a weight loss supplement that comes in capsule form available over the counter in pharmacies and drugstores around the United States. This "wonder drug" is claimed to cut fat absorption by 25% so that the user absorbs fewer calories from what he/she eats. A key active component of the Alli diet pill is Xenical, which is also known as Orlistat. Alli is intended for adult women and men and is directed to be taken daily with water. This diet product sells for $44.99 via the official website. Like many other weight reduction supplements, a healthy diet and routine exercise are encouraged. Flat Tummy Tea is another alternative that can be mixed in a glass to increase energy and burn more calories for weight loss.
- Alli is available to men and women that suffer from weight issues.
- Alli diet pills do not require a doctor's prescription.
- Alli is approved by the FDA.
- Alli Diet Pills can be easily and conveniently purchased via the official website.
- Consumer testimonials are absent from the official Alli website.
- The official Alli website fails to offer a 100% money-back guarantee.
- Some individuals may be allergic to certain ingredients found in Alli Diet Pills.
- Alli does not offer free trial samples on the official website.
- No before and after photos are provided on the Alli website.
- May cause digestion discomfort. (See reader comments.)
- Taking Alli Diet Pills can potentially result in a vitamin deficiency.
Our Conclusion on Alli
It should be noted, Stacker 2 is also a fat burner with few natural ingredients that can easily be taken on the go for weight loss. On the bright side, the Alli diet supplement is approved by the FDA. Since many other diet supplements, programs and pills aren't FDA approved; some consumers may find this approval reassuring. However, some dieters would likely be more interested in Alli supplements if the official website posted some consumer feedback, a money-back guarantee or at least a few before and after photos. Be sure to consult your doctor before taking Alli diet pills. This way you can learn more about potential side effects and other diet supplements currently available. Before you close out of this review, you might want to consider Phentabz as an alternate source as it is a fat burner that contains DMAA, caffeine, and synephrine used to burn off fat.
Alli is an over-the-counter version of Orlistat, which was originally offered as a prescription medication. It is clinically proven to bind to some of the fat you consume and flush it out of the body when you have a bowel movement. Eating excessive fat, more than 15g in a meal, can result in side effects.
Alli Ingredients and Supplement Facts
Serving Per Container: 120
|Amount per Serving||% DV|
Other Ingredients: Edible ink, gelatin, iron oxide, microcrystalline cellulose, povidone, sodium lauryl sulfate, sodium starch glycolate, talc, titanium dioxide
We researched Alli ingredients to give you the important specifics you need.
To start with, Orlistat is commonly sold under brand names such as Alli (over-the-counter version) or Xenical.  It is a prescription drug for weight-loss. It’s typically taken with doctor-approved exercise and a reduced-calorie diet plan.
What is it Supposed to Do?
Orlistat essentially prevents some of the fat you consume from being absorbed by the body. Instead, the excess fat is flushed out through the digestive tract. While this treatment for obesity is FDA approved, it can lead to some side effects like stomach pains, oily or fatty stools, gas, and spotting in your undergarments.
According to the Mayo Clinic, “People who ate a calorie-restricted diet, exercised regularly and took Alli (Orlistat) lost an average of 5.5 pounds (2.5 kilograms) more in one year than did people who only dieted and exercised.” 
FD&C Blue No. 2
FD&C Blue No. 2 is an inactive ingredient found in various pharmaceuticals, dietary supplements, cosmetics and manufactured foods. It is regulated by the FDA and is considered harmless.
What is it Supposed to Do?
The only purpose of FD&C Blue No. 2 is to function as a colorant. This is why it is often used in tablets and capsules.
There is no clinical data that supports FD&C Blue No. 2 as an active ingredient for fat loss or weight reduction. However, this substance has been researched and is considered safe as a colorant.
Edible ink is often used in the manufacture of capsules, tablets, confectionary products and other foods. It is considered safe for consumption but does not serve as an active ingredient.
What is it Supposed to Do?
The only real purpose of edible ink is to provide color to pharmaceutical capsules, dietary supplements, pastries, candy, cakes, cookies and other foods. It is often printed on edible paper made from rice.
There is no published clinical research that supports edible ink as an effective weight-loss ingredient. On the other hand, this ink has been deemed safe by the Food and Drug Administration for consumption as a food coloring.
Alli Side Effects:
In the world of weight-loss products, the words “natural” and “herbal” are often thought also to mean safe. Unfortunately, for every formula comes the potential for issues. Though Alli side effects are not guaranteed, that doesn’t exist for some that use its supplements.
Gas is a feeling of expelling air from the gastrointestinal distress through the anal cavity. Other symptoms that can be experienced along with this one may include cramps, swelling, tightness in the abdomen, and sharp pains.
What causes gas?
Gas occurs to everyone, even if it isn’t noticeable. However, it can become uncomfortable or more frequent, especially if some individuals start consuming more high fiber foods . Other reasons include swallowed air, health conditions, food intolerances, especially in herbal supplements, sweeteners, and constipation.
Bloating is usually connected to other symptoms, like gassiness and abdominal discomfort. It can also cause the appearance of weight gain.
What causes bloating?
Overeating, fatty foods, and simply eating too fast are the three most common reasons for the onset of bloating. When it happens temporarily, it should not be of concern, but it is important to seek medical attention if it is related to other, more severe symptoms or lasts for an extended period.
Diarrhea is a condition in which fecal matter is loose, watery, and can occur more frequently than usual. Although it is normal for this to last a couple of days, it can be considered an issue if it lasts any longer. Cramps, pain, a lack of bowel control, and an increased need to make a bowel movement may also occur with this symptom.
What causes diarrhea?
Some causes of diarrhea may include bacteria, viruses, medicines, herbs, food intolerances, small intestinal diseases, and issues with the colon.
According to the National Association for Continence, bowel leakage can be characterized by having trouble holding a bowel movement, having liquid stools leak from the anus, and finding streaks of fecal matter in underwear . Although it does affect both men and women, it usually occurs in the older population.
What causes bowel leakage?
Diarrhea, constipation, aging, childbirth, medication, and more are some causes of bowel leakage. Other, more severe issues may also cause the onset of this symptom.
Alli side effects are not felt by all its consumers, but there have been reports gas, bloating, diarrhea, and bowel leakage, just to name a few. To protect yourself from potential problems, it is always the best idea to consult with your physician before taking any supplement, especially if you’re taking prescription medications, are under 18, have a medical condition of any kind or are pregnant or nursing.
Alli has been around for quite some time, but we’ve heard rumblings from dieters wanting to learn more about Alli side effects. (Feel free to read our full Alli review.) We chose to look hard at the ingredients and clinical research. We also read hundreds of dieter comments to see what was happening with regular use. That information was condensed to give you the bottom line.
What You Need to Know
First off, Alli is an over-the-counter version of Xenical, a prescription weight-loss medication. You take the pill three times daily, one before each meal. It is supposed to reduce fat absorption by 25%, based on clinical studies, so this could lead to increased weight-loss. You can find a small take-along case, so you have Alli when you need it.
The product, offered up by GlaxoSmithKline, is an over-the-counter variety of Xenical or Orlistat. The ingredient has been clinically tested and approved by the Food and Drug Administration, quite the positive. It’s available for sale online and in many stores. We like that some dieters have reported weight-loss and the FDA has given it a thumb up, but read on…
Constipation – Surprising Issue
The first issue we found interesting about Alli side effects was reports of constipation. “Alli is associated with loose stools,” says our Research Editor. “We found it quite surprising that dieters claimed to suffer from difficulty using the bathroom.”
“I have been taking Alli for about 2 weeks now, and my side effects seem to be the opposite of everyone elses. I makes me very constipated. Has anyone else experienced this?,” says one user.
“I have been on and off Alli for the last few months. It made me constipated – I NEVER suffer from constipation,” offers up another.
The most common Alli side effect is diarrhea. This is associated with the way Alli works. It traps fat and pushes it out through the intestine. “I got so tired of ruining my underpants and rushing everywhere because I had to hit the bathroom whenever I was standing for a while that I had to stop taking this stuff,” reports one dieter.
Accidents are common, as claimed by another user, “I made the mistake of eating Chinese food and had a MAJOR accident at work the following morning! I WAS MORTIFIED TO SAY THE LEAST!!”
It’s with research behind us that we suggest a connection between adverse reactions, like diarrhea, and lesser chances of long-term success. If Alli side effects cause problems with dieters, that’s not exactly a benefit.
There is clinical research backing Alli weight-loss claims – there has to be because the FDA approved the drug. The benefits, however, may not be worth the Alli side effects. It is recommended that you eat no more than 45 grams of fat each day. That adds up to 405 calories. Twenty-five percent is about 101. At that rate, it would take 34 days to lose a single pound. At DietSpotlight we want science to set a product apart from other solutions. Alli just doesn’t fall into that category.
The Bottom Line
We were intrigued by Alli side effects, and with a little research, we found what we needed. We like that some users report weight-loss while on the medication, and it has been approved by the FDA, but we can’t recommend a product that only equates to the dieter losing one pound a month. We’re also concerned by the frequent reports of diarrhea and leaky bowels that cause “accidents” when least expected.
If weight-loss is at the top of your priority list, we suggest going with a supplement that doesn’t come with harmful side effects but does come with clinically proven ingredients.
Among the best supplements we’ve come across this year is Dietspotlight Burn. We like the proprietary blend of four ingredients clinically proven to help speed up metabolism and boost fat loss. We didn’t find a single report of adverse side effects, but we did find numerous dieters talking about great results.
Also, the makers of Dietspotlight Burn are confident enough in the formula to offer a Special Trial Offer, impressive.
Alli Questions & Answers:
We dug deep into reviews and experiences for Alli to create this useful FAQ.
What are the side effects of Alli?
Some of the potential side effects include gas, bloating, diarrhea and bowel leakage, according to consumer reviews and the official website.
What are the ingredients in Alli?
The only Alli ingredient is orlistat. 
Does Alli work?
Yes, there is clinical evidence Alli works as claimed. It was originally approved by the FDA in a stronger version as Xenical. It will block the absorption of fat. It will not increase metabolism or decrease hunger.
How much does Alli cost?
You can expect to pay more than $50 for 120 capsules, which is a 40-day supply. There are starter kits available, as well, that can cost between $30 and $60.
How should I take Alli?
You take one Alli pill with each meal. The company suggests keeping fat intake below 15g each time. If you exceed this amount, you are at higher risk of side effects. You are also supposed to add one healthy snack in there.
Can I take Alli if I have a health condition?
We always suggest you check with your physician before taking Alli, or another weight-loss product. We feel it is important, especially if you are currently pregnant or nursing, trying to become pregnant, taking any prescription medications, have a medical condition, or you are under 18 years old.
What do users like about Alli?
Users like that Alli has been clinically tested and proven. The ingredient has been approved by the FDA.
What do users NOT like about Alli?
The Alli side effects are a big concern with many dieters. If you accidentally eat too much fat in a meal, you may notice the difference rather quickly.
Can I take more Alli to increase weight-loss?
It is not a good idea to take more than the recommended amount of Alli. If you do, that may increase the risk of side effects, which are commonly gastrointestinal in nature.
Is there bowel leakage with Alli?
Yes, there have been reports of bowel leakage or spotting when Alli is used with a higher fat diet.
Can I eat healthy fats when taking Alli?
Yes, you can eat healthy fats when taking Alli as long as you keep amounts of total fat below 15g per meal.
How do I contact Alli customer service department?
You can contact the Alli customer service department by calling 1-800-671-2554 or by emailing Consumer.Communications@gsk.com.
Can I contact Alli through social media?
Does Alli come with a guarantee?
There’s no mention of a guarantee listed on the official website.
Do you know of any special deals or discounts on Alli?
Yes, you can sign up for the Alli newsletter to learn about savings.
Alli Scientific Abstracts:
Orlistat has been shown to have weight-loss effects by suppressing absorption of consumed dietary fat (by ∼30%). Following one and two years double-blind, placebo-controlled trials, the safety, and efficacy were determined with adverse effects being mostly gastrointestinal. Because orlistat has fat absorption capabilities, it is also able to suppress absorption of fat-soluble vitamins. It was because of this finding that it was suggested that vitamin consumption is recommended while taking orlistat. The research concluded that orlistat, through the absorption of fat, delivers a new treatment for weight-loss and weight management. Further studies are suggested during post-marketing surveillance to establish orlistat’s safety and benefits in the long-term. Orlistat is a useful tool for weight-loss in obese patients who can make alterations to their diets, exercise, and behavior. 
Orlistat has shown to be a useful adjunctive treatment for triggering weight-loss as well as improving serum lipid levels, blood pressure and glycemic control in obese individuals with type 2 diabetes already taking metformin. 
Data on the effects of orally ingested gelatin shows that gelatin strengthens fingernails as well as improving nail defects. The data prompts a discussion regarding the action gelatin has on nails most likely occurring via the metabolism of amino acids for what appears to be the specific dynamic action of gelatin. 
Sodium Lauryl Sulfate
Sodium lauryl sulfate delivered total protection of viruses in cutaneous-infected animals. Sodium lauryl sulfate completely prevented cutaneous lesions on mice that were pretreated with a sodium lauryl sulfate polymer formula. Intravaginal pretreatment with sodium lauryl sulfate within a buffered solution had protected against HSV-2 infection. It was concluded that sodium lauryl sulfate might be a useful tool as a microbicide in preventing sexually transmitted disease such as HSV, HIV, among other sexually transmitted disease-causing pathogens. 
Titanium dioxide nanoparticles were found to trigger pathological lesions of the kidney, spleen, liver, and brain when exposed intravenously. The data suggested that the significant effects could be caused by extremely high doses of titanium dioxide nanoparticles. Although titanium dioxide nanoparticles are being produced and used at a more rapid rate, there is a significant lack of epidemiological data backing it. Titanium dioxide nanoparticles have been studied thoroughly. However, the evidence is lacking regarding the possible health effects of backup risk assessment and management. 
- 1. Orlistat — A Novel Weight Loss Therapy (2001). Annals of Pharmacotherapy. July 6, 2016.
- 2. Effect of Orlistat in Overweight and Obese Patients With Type 2 Diabetes Treated With Metformin (2002). American Diabetes Association: Diabetes Care. November 3, 2016.
- 3. New Aspects Of The Effects Of Gelatin On Fingernails (1963). Society of Cosmetic Chemists. July 14, 2016.
- 4. In Vitro and In Vivo Evaluations of Sodium Lauryl Sulfate and Dextran Sulfate as Microbicides against Herpes Simplex and Human Immunodeficiency Viruses (1999). Journal of Clinical Microbiology. November 10, 2016.
- 5. Titanium dioxide nanoparticles: a review of current toxicological data (2013). Particle and Fibre Toxicology. October 6, 2016.