Updated: 12/12/2017

What are the benefits of Bio X4 4-in-1 weight-management probiotic? Our review focused on the ingredients, side effects, clinical research and quality of customer service. Furthermore, we digested hundreds of user comments and testimonials. Then, we condensed and summarized to give you the details you need.

Bio X4 Readers: Click here to find out why we're giving away samples of our product, Burn HD.

What is Bio X4?

The short answer is that Bio X4 is a weight-loss probiotic supplement. It comes in the form of a capsule. Users are instructed to take daily for maximum fat-burning and digestive health.

The formula consists of four blends that the manufacturer claims work together to support optimal digestive health, increased calorie burning and accelerated weight reduction. It also promises to help cut cravings and suppress appetite.

Bio X4 is available online only. Its manufacturer is based in the United States.

Products Similar to Bio X4

HL Slim Proread
Embrace Weight-Lossread
Burn HD (Sample offer)read

Who Makes Bio X4?

Bio X4 was developed by a health and wellness manufacturer Nucific. Nucific is headquartered in Tarzana, California (in the United States). Not only does it manufacture Bio X4, Nucific researches, develops and distributes a range of nutritional supplements, including:

Nucific Slimming Chocolates

Probiotic Complex

Dr. Amy’s Bone Broth

Deep Cell Activator


Nucific products don’t contain preservatives, synthetic fillers, antibiotics or food coloring.

A third-party labs tests the potency and quality of ingredients found in Nucific products, including Bio-X4.

Also, California recognizes Nucific as a green-friendly company that uses only renewable energy and recyclable materials for its production.

Bio X4 Customer Testimonials

Information about Nucific

Nucific, accredited Better Business Bureau, is a company with an exceptional “A” rating.

The goal of the company is to offer “cutting-edge” supplements supported by science. The fundamental principles of Nucific include:

  • Potent Ingredients
  • Quality Tested
  • Earth-Friendly
  • California-Made

Nucific maintains public visibility and communication with customers and health enthusiasts by providing educational videos and nutritional information on the official website.

Dr. Amy Lee, board-certified in internal medicine, sits on the Board of Directors as well as plays a major role in development of Nucific products. She’s an active member of the health community.


Bio X4 Ingredients

Bio X4 relies on four ingredient blends to potentially support better digestion, control food cravings, increase energy and promote weight loss. The formulas include a:

  • Probiotic blend
  • Digestive enzyme blend
  • Weight management blend
  • Craving control blend

Bio X4 Ingredients

Probiotic blend (Lactobacillus Blend):

  • L. Acidophilus
  • L. Acidophilus
  • L. Rhamnosus
  • L. Plantarum
  • Bifidobacterium Blend:
  • B. Lactis
  • B. Animalis

Digestive Enzyme Blend:

  • Amylase (from Aspergilus Oryzae)
  • Bromelain
  • Lipase (from Rhizopus Oryzae)

Weight Management Blend:

Craving Control Blend:

L. Acidophilus is a commonly used of probiotic bacteria, that may help prevent diarrhea, rebalance bacteria, fight allergies, control cholesterol and aid in digestion. [1]

The only ingredient in the Bio X4 Weight Management Blend is green tea extract.

Green tea is rich in catechins; a class of antioxidant-containing polyphenols. There’s research showing green tea may be an effective weight management ingredient.

A 12-week study found that people drinking green tea with 583 mg of catechins experienced a decrease in Body Mass Index and overall body weight as well as a reduction in abdominal fat; additionally, this green tea-supplementing group experienced a decrease in unhealthy LDL cholesterol levels. [2]

Supplementing with green tea extract before exercising may boost calorie-burning and metabolism. A test group drinking green tea before workouts showed a 17% higher rate of fat-burning verses the group who did not.

Additionally, the green tea group [noticed] a 13% decrease in insulin sensitivity, a biological function that plays an important part in metabolic activity and fat-burning. [3]

Craving Control Blend

Caralluma fimbriata extract, a wild cactus plant grown in India, contains chemical compounds thought to help control appetite.

A study examined the relationship between caralluma fimbriata supplementation, safety and weight control. The group using caralluma did show a slight decrease in BMI.

Caralluma fimbriata extract did seem to be safe and well-tolerated by the participants in the study. [4]

There is clinical evidence supporting many of Bio X4’s claims regarding the efficacy of its ingredients for weight control and overall wellness effects.

Nutritional Facts

Bio X4 Nutrition Facts

Each serving of Bio X4 is one capsule. A bottle contains 90 capsules, which is a one-month supply.

Each capsule contains:

  • Probiotic Blend – Four billion CFU (colony-forming units)
  • Digestive Blend – 43mg
  • Weight Management Blend – 100mg
  • Craving Control Blend –  166mg

The capsules are 100% gluten-free and do not contain any common allergens.

Does Bio X4 Work?

Bio X4 is formulated to provide gastrointestinal tract support by supplying beneficial gut bacteria.

This in-turn may help optimize health and promote weight loss.

Probiotics, such as Bio X4, may help, restore “good” bacteria in your body and balance bacteria levels.

Does Bio X4 Work
Bio X4 ingredients such as green tea may increase energy and metabolism. Ingredients like caralluma fimbriata may suppress appetite. Through increased metabolism, boosts in energy levels and curbing appetite; Bio X4 may help users feel better and lose weight.

Bio X4 Results

As with most nutritional supplements, the longer you maintain usage on a daily basis, the greater the results you may see. The manufacturer recommends maintaining a steady daily regimen and, if you happen to miss a day, do not try to make up for the dose; simply take the recommended dose per usual.

As for seeing peak results, the manufacturer states that you should be able to evaluate its max performance for you in 60 days effectively. Of course, instructions specify that you have to take the capsules regularly (on a daily basis) for them to work at their maximum capability.

Side Effects

Bio X4 Side Effects

Nucific — Bio X4’s parent company — says there are no known side effects and that it is safe for most adult consumption.

While this may be true in general, it is important to note that anyone considering this supplement should read the nutrition label carefully to make sure none of the ingredients will trigger an allergic reaction (for those with certain food allergies). Better yet, it is always wise to consult with a nutritional or medical professional before beginning use.

Are There Bio X4 Side Effects to Worry About

In addition to triggering allergies and interacting with certain medications, nutritional supplements can sometimes produce mild side effects might such as:

  • Upset stomach
  • Gas
  • Diarrhea
  • Bloating

Always read the product label carefully and stick to the recommended dosage.

Bio X4 Benefits

This fat-burning probiotic claims to provide a whole host of wellness benefits. Here are a few:

Potential Bio X4 Pros

  • It may promote optimal digestive health.
  • The manufacturer offers package deals.
  • It may improve bowel regularity.
  • It may enhance immune system health.
  • It may support higher energy levels.

Potential Bio X4 Cons

However, you should also examine the converse: There are always potential risks and cons to consider when choosing a new dietary supplement. Here is a quick list:

  • There isn’t any definitive scientific proof it does everything it claims to do.
  • It is fairly expensive.
  • It must be taken on a regular basis to experience maximal effects.
  • Some users may have trouble remembering to take the capsules three times a day.

Bio X4 Benefits

Ultimately, it’s up to you and your healthcare provider to determine which is the best weight control nutritional supplement for you.


Is There a Bio X4 Alternative?

There are indeed a wide array of dietary probiotic weight control supplements on the market, so much so that it can be an anxiety-inducing experience even to begin to research them all. To help you narrow your search for the right supplement, here are a few guidelines to keep in mind when deciding whether Bio X4 or an alternative supplement may be right for your needs.

Here are a few pointers:

Always purchase from a reputable manufacturer or another vendor, and look for GMP (Good Manufacturing Practice) certification to ensure the product was produced in a quality lab.

Always look for quality ingredients but also a balance of additives that are known to work well in combination.

What Does Bio X4 Cost?

Fortunately for committed Bio X4 enthusiasts, the manufacturer offers not only single bottles for sale but also two additional multi–purchase promo offers to help users stock up and save.

A single bottle of this supplement — which contains a one-month supply of capsules — retails for $49 on the manufacturer website, which states that this price reflects a $50 savings off the regular price. Another plus is that shipping and handling is free (although it is unclear whether the manufacturer also offers shipping insurance as an option).

Aside from the original manufacturer, prices per bottle will vary. If you aren’t going to purchase from Nucific directly, make sure to read all company policies carefully as well as reviews associated with the vendor.


Are There Any Bio X4 Specials?

Each Bio X4 purchase from the original manufacturer comes with a 90-day money-back satisfaction guarantee.

The first Bio X4 package deal offers the discounted price of $129 for three bottles, a price the manufacturer claims reflects a $56 savings per bottle. The second and top-tier package deal offers six bottles of Bio X4 for $240.

Are There Any Bio X4 Specials

Customers can also enter a coupon code at checkout for further savings (depending on the available promotions at the time of sale).

Where Can I Buy Bio X4?

Because this weight loss supplement is fairly new to the market, it is not available in stores at this time. Anyone interested should purchase directly from the manufacturer to ensure authenticity and freshness. Otherwise, there are some reputable supplement vendors online from which to purchase.

Always do your research when considering a vendor. Again, read all company policies closely as well as any reviews associated with the company.

Where to Buy

Bio X4 Directions

Per product instructions, users are to take one Bio X4 capsule with each meal. This includes breakfast, lunch and dinner for a total of three capsules daily. By supplementing with each meal, the pills are designed to support digestive processes with fewer tummy troubles and potentially even greater nutrient absorption.

Daily supplementation, according to claims, may lead to greatly enhanced digestive health as well as faster weight loss.


Bio X4 Weight Loss

Caralluma fimbriata is one of the ingredients connecting Bio X4 to weight loss. Research shows users reduced body fat and decreased appetite. [5]

Green Tea, Bio X4 and Weight Loss

Green tea has been used for many years in a myriad of cultures for its health benefits. Supplementing with the green tea may help increase metabolism, decreased body fat and help you lose weight. It also contains caffeine; thought to accelerate metabolism and energy levels.

A meta-analysis conducted on green tea’s effects on BMI and weight maintenance found that the catechins present in green tea significantly decreased body weight as well as significantly maintained this reduced weight afterward.

How Does Green Tea Extract Help With Weight Loss

What Users Are Saying

“I tried this primarily for the probiotic impact. As I’ve gotten older, I’ve started to have minor digestive issues and increased bloating. It took a good couple of weeks for the effects to kick in but once it did, I felt a great deal better. I broke down and bought Bio-x4 strictly for the Probiotic benefits.”

“It helps with digestion.”

Also: read our Burn HD Weight-Loss Kit review »Bio X4 Ingredients

The Bottom Line on Bio X4

There is little doubt that Bio X4 has become a popular nutritional probiotic and weight control supplement among consumers. Most of its ingredients have a historical, worldwide use for weight loss and health. We also like that Nucific is a trusted brand offering a 4-in-1 supplement promoting health and wellness.

If you’re at the point you want to lose those extra pounds, consider adding a supplement containing clinically-tested ingredients to the mix.

Another product we’ve seen this year is one called Dietspotlight Burn. It contains four clinically-tested ingredients and has been shown to help ignite metabolic rate and ignite fat loss. Customers share their experiences seeing great results.

Plus, the makers of Dietspotlight Burn are so confident in their supplement, that they’re offering customers a Special Trial Offer.

Does It Work?

Learn More About Burn HD »

Bio X4

What are Bio X4 ingredients?

Bio X4 ingredients are L. acidophilus, L. rhamnosus, L. plantarum, B. lactis, B. animalis, amylase, bromelain, lipase, green tea extract and Slimaluma (caralluma fimbriata).

Does Bio X4 work?

There’s a connection between Bio X4 and weight-management. The four-in-one formula also promotes digestive health.

How do I know if Bio X4 is right for me?

Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients.

Click here to get your sample of our powerful fat burner today.

How much does Bio X4 cost?

Bio X4 costs $99 for a 30-day supply.

What is Bio X4’s BBB rating?

The Better Business Bureau (BBB) rating for Nucific, the company behind Bio X4, is an A.

How should I take Bio X4?

You take one capsule before each meal.

How long does it take to see the effects of Bio X4?

It can take between 30 and 60 days to see results from Bio X4, but some users have noticed results sooner then that.

Does Bio X4 come with a guarantee?

Yes, there is a 90-day money-back guarantee with your Bio X4 purchase.

Bio X4 Ingredients

Bio X4 Ingredients and Supplement Facts

Serving Size: 1 Capsule
Serving Per Container: 90
Amount per Serving% DV
Probiotic Blend4 Billion*
- Lactobacillus Blend**
- L. acidophilus**
- L. rhamnosus**
- L. plantarum**
- Bifidobacterum Blend**
- B. Lactis**
- B. animalis**
Digestive Enzyme Blend88 mg*
- Amylase**
- Bromelain**
- Lipase**
Weight Management Blend100 mg*
- Green Tea Extract**
Craving Control Blend166 mg*
- Caralluma Fimbraiata Extract**

Other Ingredients: Vegetable cellulose, rice bran and silica.

Summer Banks Dietspotlight Author
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.

6 Bio X4 Reviews

  • Angela

    can I take bio x4 while pregnant?

  • Moriba

    Can I take this if i have high blood pressure and diabetes

    • Kaye

      Hello Monba, I have Hbp and diabetes I feel better only been taking them for a couple of weeks and , have more energy blood sugar is good have lost a couple pounds, I’ve started walking ,will keep you posted if you like me too

      • Bonnie Johnson


        Hi Moriba and Kaye, I am also Type 2 Diabetic and have Hbp as well. I have just started taking Bio X4 in the last 3 days. The biggest thing that I notice is that I don’t have any cravings and I am satisfied with less food as well as making better choices in the foods I am eating. Also I have stopped putting sweetener or sugar in my coffee and and shocked that I am not missing it. Kay, have you missed taking Bio X4 before a meal? If so what did you do? Thanks for sharing your posts.

  • I forgot to take it before my meal.
    Bonnie Johnson

    I forgot to take it before my meal. Should I take it while I am eating or just skip it?

    • Victoria (Editor)

      Hi Bonnie! The product label currently states that “whenever you are about to eat, simply take one capsule of Bio-X4 beforehand. Then, enjoy your meal!”. So, it might be best to just re-start fresh tomorrow since you forgot to take the product today.