Updated: 10/10/2017
By Summer Banks Sep 08, 2017

What are the benefits of Bio X4 4-in-1 weight-management probiotic? Our review focused on the ingredients, side effects, clinical research and quality of customer service. Furthermore, we digested hundreds of user comments and testimonials. Then, we condensed and summarized to give you the details you need.

Bio X4 Readers: Click here to find out why we're giving away samples of our product, Burn HD.

What is Bio X4?

First off, Bio X4 is a 4-in-1 weight-management probiotic. It contains a Lactobacillus Blend, Bifidobacterum Blend, Digestive Enzyme Blend, green tea extract and Slimaluma (caralluma fimbriata). You take one capsule before each meal. Users report seeing a reduction in cravings, fat loss, increased energy and improved digestive health.

Nucific, the company that makes Bio X4, started online in 2015. You can buy directly from the official website and there is a savings if you buy multiple bottles. We like the effect of probiotics on the digestive system and and the use of natural ingredients, but read on…

Positive Effects From Bio X4

The first thing we took a closer look at was Bio X4 side effects. “The supplement intends to promote digestive health,” said our Research Editor. “Customer experiences rarely talk about side effects.”

“I did seem to have more energy and I was very regular without any bad side effects,” said a customer.

“There were no bad side effects in taking these,” offered another.

“So far it seems to have some positive effects in terms of comfort when eating carbs,” reported a dieter.

Bio X4 Customer Testimonials

Top Notch Customer Service From Bio X4

According to Bio X4 reviews, the customer service team is there to help. As one user said, “Good experience so far,” said a customer.

One also said, “Sent emails to support@nucific.com, and they addressed my concerns,” stated a dieter.

“I found answers in the FAQ, but verified the info with the customer service team,” commented a user.

“Great service and support. Thank you,” mentioned another.

We’ve found that great customer service equals long-term success. Chances are that when dieters have questions, they’ll receive answers from the Bio X4 customer service department.

The Science Supporting the Ingredients

At DietSpotlight, we look for solid science supporting claims. With Bio X4, there’s solid research. We found studies supporting the effectiveness of caralluma fimbriata [1], EGCG found in green tea [2] and probiotics [3] [4]. The parent company, Nucific, also provides additional details about each ingredient used in the formula.

What Users Are Saying

"I tried this primarily for the probiotic impact. As I’ve gotten older, I’ve started to have minor digestive issues and increased bloating. It took a good couple of weeks for the effects to kick in but once it did, I felt a great deal better. I didn’t notice any appetite suppression and I didn’t feel a significant impact to my energy level, but some. Given the cost, I thought I would try a cheaper Probiotic supplement (Dr. Tobias). I can definitely tell the difference. Doesn’t work at all. So, I broke down and bought Bio-x4 strictly for the Probiotic benefits."

"It helps with digestion but it is too expensive"

"Doesn’t do what it claims to do."

Also: read our Burn HD Weight-Loss Kit review »Bio X4 Ingredients

The Bottom Line – Does Bio X4 Work?

A 4-in-1 weight-management probiotic? Yes please. We like that Bio X4 ingredients don’t lactose or fillers. It’s also great to see a new company offers research-based evidence supporting the claims. We also like the idea of adding probiotics to improve digestive health.

If you’re at the point you want to lose those extra pounds, consider adding a supplement containing clinically-tested ingredients to the mix.

Another product we’ve seen this year is one called Dietspotlight Burn. It contains four clinically-tested ingredients and has been shown to help ignite metabolic rate and ignite fat loss. Customers share their experiences seeing great results and there’s no talk of harmful side effects

Plus, the makers of Dietspotlight Burn are so confident in their supplement, that they’re offering customers a Special Trial Offer.

Bio X4 Ingredients and Supplement Facts

Serving Size: 1 Capsule
Serving Per Container: 90
Amount per Serving% DV
Probiotic Blend4 Billion*
- Lactobacillus Blend**
- L. acidophilus**
- L. rhamnosus**
- L. plantarum**
- Bifidobacterum Blend**
- B. Lactis**
- B. animalis**
Digestive Enzyme Blend88 mg*
- Amylase**
- Bromelain**
- Lipase**
Weight Management Blend100 mg*
- Green Tea Extract**
Craving Control Blend166 mg*
- Caralluma Fimbraiata Extract**

Other Ingredients: Vegetable cellulose, rice bran and silica.

Learn More About Burn HD »
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.

Rating: 3.5. From 56 votes.
Please wait...

Bio X4

What are the ingredients in Bio X4?

Bio X4 ingredients are L. acidophilus, L. rhamnosus, L. plantarum, B. lactis, B. animalis, amylase, bromelain, lipase, green tea extract and Slimaluma (caralluma fimbriata).

Does Bio X4 work?

There’s a connection between Bio X4 and weight-management. The four-in-one formula also promotes digestive health.

How do I know if Bio X4 is right for me?

Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients.

Click here to get your sample of our powerful fat burner today.

How much does Bio X4 cost?

Bio X4 costs $99 for a 30-day supply.

What is Bio X4’s BBB rating?

The Better Business Bureau (BBB) rating for Nucific, the company behind Bio X4, is an A.

How should I take Bio X4?

You take one capsule before each meal.

How long does it take to see the effects of Bio X4?

It can take between 30 and 60 days to see results from Bio X4, but some users have noticed results sooner then that.

Does Bio X4 come with a guarantee?

Yes, there is a 90-day money-back guarantee with your Bio X4 purchase.

Bio X4 Reviews

Leave a comment or review


can I take bio x4 while pregnant?


Can I take this if i have high blood pressure and diabetes


Hello Monba, I have Hbp and diabetes I feel better only been taking them for a couple of weeks and , have more energy blood sugar is good have lost a couple pounds, I’ve started walking ,will keep you posted if you like me too

Bonnie Johnson


Hi Moriba and Kaye, I am also Type 2 Diabetic and have Hbp as well. I have just started taking Bio X4 in the last 3 days. The biggest thing that I notice is that I don’t have any cravings and I am satisfied with less food as well as making better choices in the foods I am eating. Also I have stopped putting sweetener or sugar in my coffee and and shocked that I am not missing it. Kay, have you missed taking Bio X4 before a meal? If so what did you do? Thanks for sharing your posts.

I forgot to take it before my meal.
Bonnie Johnson

I forgot to take it before my meal. Should I take it while I am eating or just skip it?

Victoria (Editor)

Hi Bonnie! The product label currently states that “whenever you are about to eat, simply take one capsule of Bio-X4 beforehand. Then, enjoy your meal!”. So, it might be best to just re-start fresh tomorrow since you forgot to take the product today.