Update: - Advertising Disclosure

Bio X4 Review - 15 Things You Need to Know

Probiotic supplement Bio X4 is a product that aims at reducing hunger pangs while boosting metabolism and aiding in digestive health. The company claims its two main ingredients, caralluma fimbriata and EGCG ‘work in concert’ with its probiotic content to speed up your weight loss. However, they offer no evidence to suggest that this blend actually works.

Our researchers had difficulty finding scientific data that Bio X4’s formula lives up to its claims. Offering better digestive health is key for any weight loss product, but Bio X4’s correlation to the latter may be weak. We looked at all facets of this product to provide you with the synopsis found here.

Bio X4 can be purchased through their Official Site.

Bio X4 Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Bio X4?

What is Bio X4

Bio X4 is a weight-loss probiotic supplement. The company behind Bio X4 claims the 4-in-1 weight management probiotic helps you take control of your appetite, manage food cravings, boost metabolism, and digestion to feel better than ever. So, we started out checking some of the weight-loss ingredients.

  • British Journal of Clinical Pharmacology – Green tea supplements “improve exercise-induced body composition.”
  • Perspectives in Clinical Research – Examined the relationship between Caralluma Fimbriata supplementation, safety, and weight control. The group using Caralluma did show a slight decrease in BMI.
  • Appetite – “Caralluma extract appears to suppress appetite, and reduce waist circumference when compared to placebo over a 2 month period.”

Customer Service Information

You can contact customer service a variety of ways including email, form, and chat.

Address: 30700 Russell Ranch Rd Westlake Village, CA 91362

Email: support@nucific.com

Phone: 888-679-5520

Hours: Mon – Fri 6 AM-5 PM PST, Sat-Sun 6 AM-4 PM PST

Chat and Contact form: https://nucific.com/contact/

Nucific and the Better Business Bureau (BBB)

Nucific has an active BBB page. Let’s check out what it tells us about Bio X4’s creator.

  • Nucific has been accredited by the BBB since 2016.
  • Their overall rating is an A+.
  • The average of 504 customer reviews is 4.31/5 stars.
  • These last three years, 108 complaints were closed.
  • Last 12 months, 4 complaints were closed.

Bio X4 Competitors

ActivatedYou Morning Complete
Alani Nu
Chobani Probiotic
Company Bio

Who Makes Bio X4?

Health and wellness manufacturer Nucific developed Bio x4. Bio X4 isn’t the only supplement from Nucific; the company also researches, develops, and distributes nutritional supplements, including:

  • Nucific Slimming Chocolates
  • Probiotic Complex
  • Deep Cell Activator
  • Bio-X4
  • Carb-C6
  • Prebio Cleanse
  • PrebioBoost
  • Antarctic Krill Oil
  • Advanced Slimming Probiotic
  • Nighttime Slimming Complex
  • UltraSlim-X3
  • MoroSlim
  • NutraTrim
  • Move 360
  • Hunger Balance Advanced Formula
  • Morning Boost
  • Daily Energy Boost

Nucific products do not contain preservatives, synthetic fillers, antibiotics, or food coloring. Also, the supplements are 100% natural. An independent third party facility lab-tests the potency and quality of ingredients in Nucific products, including Bio-X4.

California recognizes Nucific as a green-friendly company using only renewable energy and recyclable materials.

Company Information

Nucific Company Profile

Nucific is a Better Business Bureau accredited company with an “A+” rating.

The goal of the company is to offer “cutting-edge” supplements supported by science. The fundamental principles of Nucific are:

  • Potent Ingredients
  • Quality Testing
  • Earth-Friendly
  • California-Made

Nucific maintains public visibility and communication with customers and health enthusiasts by providing educational videos and nutritional information on their official website. It’s important to note that Nucific donates a portion of proceeds from every purchase to Action Against Hunger.

Dr. Amy Lee, board-certified in internal medicine, sits on the Board of Directors. She also plays a significant role in developing Nucific products and is an active community member.

Dr. Amy Lee’s Three Harmful Foods

Dr. Lee made a video discussing three harmful types of “healthy foods” not banned by the FDA, including:

  • Yogurt with added sugars
  • Wheat bread
  • Cereal bars

Bio X4 Ingredients

Bio X4 Ingredients

Nucific BioX4 relies on four-ingredient blends to potentially support better digestion, control food cravings, increase energy, and promote weight loss. The formulas include a:

  • Probiotic blend
  • Digestive enzyme blend
  • Weight management blend
  • Craving control blend

Probiotic blend

Lactobacillus Blend:

By taking 3 capsules per day, you cumulatively ingest 39 billion CFUs.

  • L. Acidophilus
  • L. Rhamnosus
  • L. Plantarum

Bifidobacterium Blend:

The BioX4 ingredients for this blend include:

  • B. Lactis
  • B. Animalis

Do Probiotics Support Weight Loss?

Research published in a 2018 edition of Nutrients shared that “further studies are needed before probiotics can be rationally prescribed for the prevention of treatment of obesity.”

Synbiotics, which is a combination of probiotics and prebiotics, may be a more effective option for weight loss, according to the European Review of Medical and Pharmacological Sciences.

Digestive Enzyme Blend

  • Amylase (from Aspergillus Oryzae)
  • Bromelain
  • Lipase (from Rhizopus Oryzae)

Is There a Link Between Digestive Enzymes and Weight Loss?

We didn’t find a link of any sort between digestive enzymes and weight loss. We do know that these enzymes can help in cases of gastrointestinal health issues, according to Current Drug Metabolism. And, we know the gut microbiome is different in people who are obese, so maybe there’s a connection there science has yet to discover.

Weight Management Blend

  • Green tea extract (50% EGCG)

Let’s Talk Green Tea and Weight Loss

There are at least two distinct parts of green tea that promote weight loss – caffeine and EGCG. We’ll look at both. Caffeine is considered the world’s favorite drug. Literally millions of people start their day with coffee and many choose to drink it, and other caffeinated beverages, throughout the day. Thankfully, the European Journal of Clinical Nutrition shared research in 2016 that showed caffeine is, in fact, “related to successful weight loss maintenance.” Now, that’s maintenance after you’ve lost weight.

What about actively losing weight? That’s where the caffeine and EGCG relationship comes into play. According to Molecules, “Meta-analysis suggests that catechins and caffeine synergistically produced weight-loss effects, as opposed to the result of caffeine alone.”

Craving Control Blend

  • Caralluma Fimbriata Extract

Now, How About Caralluma Fimbriata and Weight Loss?

Caralluma Fimbriata extract is a wild cactus plant grown in India, containing chemical compounds that supposedly help control appetite, according to older research in the journal Appetite. Jump forward to 2015, and research now claims that taking upwards of 1,000mg a day of caralluma has no impact on appetite in overweight and obese individuals, according to Perspectives in Clinical Research.

Nutrition Facts

Bio X4 Nutrition Facts

Each serving of Bio X4 is one capsule, with one bottle containing 90 capsules or a one-month supply.

Each Bio X4 capsule contains:

  • Probiotic Blend – 4 billion CFUs (colony-forming units)
  • Digestive Blend – 43mg
  • Weight Management Blend – 100mg
  • Craving Control Blend –  166mg

The capsules are 100% gluten-free and do not contain any common allergens.

Does It Work?

Does Bio X4 Work?

Does Bio X4 Work

Bio X4 is formulated to provide gastrointestinal tract support by supplying beneficial gut bacteria. This, in turn, may help optimize health and promote weight loss. According to research in the journal Nutrientsprobiotics may help restore “good” bacteria in your body and balance bacteria levels.

Bio X4 ingredients such as green tea may increase energy and metabolism.

Ingredients like Caralluma Fimbriata may suppress appetite. Through increased metabolic rate, boosted energy levels, and curbing appetite, some BioX4 reviews show the product may help users feel better and lose weight.

Benefits and Results

Bio X4 Results

As with most nutritional supplements, the longer you maintain usage daily, the greater the results you may see. The manufacturer recommends maintaining a steady daily regimen. If you happen to miss a day, do not try to make up for the dose; simply take the recommended dose as per usual.

As for seeing peak results, the manufacturer states you should effectively evaluate its max performance for you in 60 days. Of course, instructions specify you have to take the capsules daily to maximize results.

The company states that as long as you keep working out and avoid eating sweets, you should see results within a couple of months of taking the product.

Side Effects

Bio X4 Side Effects

Nucific states there is no known side effect and that it is safe for most adults.

While this may be true in general, it is essential to note that anyone considering this supplement should carefully read the nutrition label to make sure none of the ingredients will trigger an allergic reaction (for those with specific food allergies). Always read the product label carefully and stick to the recommended dosage.

Pros and Cons

Bio X4 Pros & Cons


  • Promotes optimal digestive health.
  • The manufacturer offers package deals.
  • Improves bowel regularity.
  • Enhances immune system health.
  • Supports higher energy levels.
  • Gluten-, allergen-, and lactose-free.
  • 90-day money-back guarantee.
  • Eco-friendly packaging.
  • Third-party lab tests.
  • Transparent about board members and their qualifications.
  • Useful health blog on the official website.


  • Expensive for some.
  • You must take it regularly to experience maximal effects.
  • Some users may have trouble remembering to take the capsules three times a day.
  • Only available online.

Ultimately, it’s up to you and your healthcare provider to determine which nutritional supplement’s best weight control is for you.


Bio X4 Alternatives

Bio X4 Alternatives

There is a wide array of dietary probiotic weight control supplements on the market, so much so that it can be anxiety-inducing to research them all. To help you narrow your search for the right supplement, here are a few guidelines to keep in mind when deciding whether Bio X4 or an alternative is suitable for your needs.

Always purchase from a reputable manufacturer or another vendor, and look for the GMP (Good Manufacturing Practice) certification to ensure a quality lab produced the product.

Always look for quality ingredients and a balance of additives that you know to work well in combination.

Bio X4 alternatives include:


Bio X4 Price

The manufacturer offers single bottles for sale, and two additional multi-purchase promo offers to help users stock up and save.

Bio X4 prices on the official website include:

  • One bottle (30-day supply): $99
  • Three bottles (90-day supply): $261.36
  • Six bottles (180-day supply): $487.08

These prices may vary based on internet sales.

Aside from the original manufacturer, prices per bottle will vary. If you aren’t going to purchase from Nucific directly, make sure to read all company policies carefully and reviews associated with the vendor. Nucific offers a 90-day money-back guarantee on purchases. Additionally, a BioX4 coupon code may be available on the official website.

Are There Any Bio X4 Specials?

Each Bio X4 purchase from the original manufacturer comes with a 90-day money-back satisfaction guarantee.

The first Bio X4 package deal offers the discounted price of $261.36 for three bottles, a price the manufacturer claims reflects a $35.64 savings. The second and top-tier package deal offers six bottles of Bio X4 for $487.08 – a savings of over $106.92.

Customers can also enter a coupon code at checkout for further savings, depending on the available promotions at the time of sale. Individuals may also find deals for BioX4 on Amazon.

Where To Buy

Where Can I Buy Bio X4?

Because this weight-loss supplement is relatively new to the market, it is not available in stores. Anyone interested should purchase it directly from the manufacturer to ensure authenticity and freshness.

Always do your research when considering a vendor. Again, read all company policies closely as well as any reviews associated with the company.


Bio X4 Directions

Per product instructions, users are to take one Bio X4 capsule with each meal. This includes breakfast, lunch, and dinner, for a total of three capsules daily.

You may take up to two capsules per meal, but do not take more than six in a day.

The pills are designed to support digestive processes with fewer tummy troubles and potentially even greater nutrient absorption by supplementing with each meal.

Daily supplementation, according to claims, may lead to significantly enhanced digestive health as well as faster weight loss.

What Users Are Saying

What Users Are Saying

“Used consistently for 1 month with no observable changes, positive or negative. No difference in any way.”

“Caused extreme, tight bloating in my abdomen. It was very uncomfortable.”

“I started using this the first of April. I was trying to lose about 5 pounds. My regimen before was diet control and activity, walking an average of 3 miles a day. My pandemic weight persisted on this regimen. I added the pills, taking as many as 5 a day (max is 6). At first, not much happened. After several days, I started losing weight gradually and consistently. Today I’m down about 7 pounds from my start. I cannot swear that the pills did it, but it certainly seems like it! Either way I’m happy with my results!”

Bottom Line

The Bottom Line on Bio X4

There is little doubt that Bio X4 is a popular nutritional probiotic and weight control supplement among consumers. Most of its ingredients have a historical, worldwide use for weight loss and health. We also like that Nucific is a trusted brand offering a 4-in-1 supplement promoting health and wellness.

When it comes to losing weight, changing how you live and eat can be a difficult process. This is especially true if you don’t have the support you need to stick with those changes. There’s one solution out there that we’ve found helps more than you’d think.

Among the best weight-loss programs we’ve found today is Noom. The app works with expert nutritionists and doctors to create a platform where you can lose weight and keep it off with human coaching, personalized meal plans, and more.

Take advantage of a free trial offer of Noom that’s available to Dietspotlight readers today.

Learn More About Noom »
Bio X4 Review
Bio X4 Customers Also Bought:
Free Trial Offer
Explanation of Chart
Garcinia Cambogia
Caralluma Fimbriata

Bio X4

Does Bio X4 help you lose weight?

Bio X4 is not a weight-loss supplement, but may help with weight-loss. Probiotics support gut health, which is crucial for losing weight.

What are Bio X4 ingredients?

Bio X4 ingredients are L. acidophilus, L. rhamnosus, L. plantarum, B. lactis, B. animalis, amylase, bromelain, lipase, green tea extract and Slimaluma (caralluma fimbriata).

What does Bio X4 do for you?

BioX4 may help with weight management. The four-in-one formula also supports digestive health.

How should I take Bio X4?

Take one capsule before each meal. You may take two capsules with each meal as long as you do not take more than six capsules a day.

How long does it take to see the effects of Bio X4?

It can take between 30 and 60 days to see results from Bio X4, but some users have noticed results sooner than that.

Where can I buy Bio X4?

Bio X4 can be purchased using their Official Site.

Does Bio X4 come with a guarantee?

Yes, there is a 90-day money-back guarantee on Bio X4 products.

Does Bio X4 contain caffeine?

Since Bio X4 contains 100 mg of green tea in each serving, trace amounts of caffeine are present.

Is Bio X4 vegan?

Although Bio X4 is not vegan, it is vegetarian, lactose-free, and gluten-free.

Is BioX4 legitimate?

Bio X4 is a legitimate product available from Nucific that claims to improve digestive health.

Is Dr. Amy Lee a real doctor?

Dr. Amy Lee is a real board-certified physician that obtained her doctorate from the University of Illinois.

Does BioX4 really work?

Since BioX4 contains some healthy probiotic ingredients, some customer reviews claim it really works for digestive issues like gas and bloating.

Is BioX4 a scam?

BioX4 is a real product offered by Nucific, not a scam.

Can Bio-x4 be taken on an empty stomach at bedtime?

Bio-x4 capsules should be taken with meals and you should not exceed 6 capsules a day.

59 Bio X4 Reviews

  • Digestive help

    I need improvement with my digestive health.But I know that the green tea will harm my sleeping.I want to orderThe BioX4 because it could help my bathroom habits.What do you suggest I do instead?

    • Montana (Editor)

      Hello Louise. It may be best to consult with your physician to see which option is best for you.

  • Brenda (Verified Purchase)

    Can u eat anything while taking biox4 or do u have to be on a special diet

    • Montana (Editor)

      Hello Brenda. Bio X4 does not specify a particular diet to follow while using their product.

  • Anonymous

    Can I take Bio X4 with my Goli Apple Cider Vinegar Gummies?

  • Rosa I madriz de Robledo

    I received the Bio X4 exp date is expire 03/2020 anf ro DIgestive comfort complet exp date 07/2018, I will return the product

  • Green Tea
    lynn burner (Verified Purchase)

    I have not been sleeping well while taking this product. Does anyone else have this issue?

    • Megan

      I have not had this problem. I’m wondering if something else is causing your insomnia, which I have had before!! Do you eat dinner late? Don’t eat after 7:00! Try going through a bedtime routine each night. This tells your brain it’s bedtime and will make you sleepy. Wash your face, brush your teeth, turn down the bed, read a little in bed with a soft light. Hopefully you will fall asleep and stay asleep.

  • Anonymous

    Is biox4 safe for all ages? Does it have a certain age range?

    • Montana (Editor)

      According to the official Nucific website, Bio X4 is safe to use for people of all ages.

  • Sue

    I usually have fruit on the way to work then lunch & dinner, can I do just 2 capsules a day?

    • Montana (Editor)

      According to the official Bio X4 website, “For optimal results, take 1 capsule of BIO X4 with each meal – breakfast, lunch and dinner.”

  • Anonymous

    Does this product have pork in it ? Or should I say gelatin

    • Montana (Editor)

      Bio X4 does not contain any gelatin.

  • Anonymous

    Does this have any animal product inside of it for example gelatin from pigs?

    • Montana (Editor)

      Bio X4 does not contain any gelatin.

  • Again, Shelf LIfe?

    What is the shelf life for Bio X4? Did not see a reply to that question and I am wondering the same thing.

    • Montana (Editor)

      Bio X4 does not specify a shelf life for their supplements, but each bottle should have a clearly labeled expiration date.

      • kim

        hello where can i find the expiry date on my bottle? I don’t see it…

        • Montana (Editor)

          A manufacture or expiration date should be labeled on the bottle or cap. If Bio X4 doesn’t mark this on the bottle, we suggest contacting Nucific for more information.

          • joette Kippes

            The only thing on the bottle is the Lot # and MFG date. My bottle says MFG date of 9/2017. No date on the cap or inside the cap. So what is the shelf life?

  • Shelf life
    Howard Maculsay

    What is the shelf life of Bio X4

  • Anonymous

    Can u take this if u have thyroid problems?

  • Possible SSRI interaction.
    Julie Smith (Verified Purchase)

    Don’t take if you use an SSRI. May interact and cause negative effects. Nucific declines to release research on this matter stating it was confidential. I wouldn’t trust them.

    • Megan

      I’m taking Prozac daily and am also taking Bio X4. Is it true taking these will have negative side effects? And what type of negative side effects?

  • I like it but my doctor doesnt.
    Joyce Walker (Verified Purchase)

    I’ve taken BioX4 for three months now. I have problems with occasional diverticulosis. The product appears to control my bowels causing me to not experience any diarrhea. However, my gastrointestinal specialist advises me not to take it because of the lack of regulation and one item in the product that she’s not aware of.

    • Ewa

      Which item.? I have the same problem
      Thank you for sharing your experience 🌹
      Also I have high insulin level ( insulin resistance) and hoping that will be good for me to try
      Thank you

  • Bio X4 and Kidney Health

    Is Bio X4 good for people with all stages of kidney disease?

    • Angelica (Editor)

      Hi Crystal,

      We do suggest that you consult with your physician if you have any pre-existing conditions or are worried that a product may conflict with a medication

  • Richard Ligotti (Verified Purchase)

    I tried Bio X4 in August 2017, I do not recall seeing any meaningful results. Just watched the video of Dr. Lee, very impressive; than I checked my emails to see if I ever tried this product and sure enough there was the order confirmation in Aug. 2017. If it had worked i would have continued purchasing it. It is amazing how convincing the product videos can be. I did not bother, taking advantage of the money back offer.

  • Megan

    If I was to start taking Bio X4 does that then mean that I would have to take it for the rest of my life to maintain a steady and healthy weight ? Or do I stop after I’ve reached my desired weight and take it every now and then instead of everyday ?

    • Janie Whitehead

      I didn’t see the answer to a question if i take the Bio x4 if I do loose weiight, will i have to take the pills the rest of my life.?

    • Megan

      I’d like to know the answer to this question. Do I have to take it the rest of my life?

  • Angela

    can I take bio x4 while pregnant?

    • Larry

      Ask your doctor! Believe no one else…

    • Anonymous


  • Moriba

    Can I take this if i have high blood pressure and diabetes

    • Anonymous

      Can this product be taken if Inhqve high blood pressure

      • Montana (Editor)

        We suggest consulting with your doctor to see if this product is safe for you.

  • I forgot to take it before my meal.
    Bonnie Johnson

    I forgot to take it before my meal. Should I take it while I am eating or just skip it?

    • Victoria (Editor)

      Hi Bonnie! The product label currently states that “whenever you are about to eat, simply take one capsule of Bio-X4 beforehand. Then, enjoy your meal!”. So, it might be best to just re-start fresh tomorrow since you forgot to take the product today.

    • Maxine

      It’s says take it with meal so before or after is probabaly okay.

      • Larry

        I would say, before or during.. not quite sure about after.

    • BJames

      The directions on the bottle say it should be taken WITH each meal, not necessarily before a meal. I usually take it after I’ve had a few bites of my meal.

    • Hope

      Just watched dr. Lee’s video and she specifically stated just before you eat your meal.
      Remember, not everyone reacts to any supplement or medicine the same way.

Load More