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Bio X4 Review - 15 Things You Need to Know

Probiotic supplement Bio X4 is a product that aims at reducing hunger pangs while boosting metabolism and aiding in digestive health. The company claims its two main ingredients, caralluma fimbriata and EGCG ‘work in concert’ with its probiotic content to speed up your weight loss. However, they offer no evidence to suggest that this blend actually works.

Our researchers had difficulty finding scientific data that Bio X4’s formula lives up to its claims. Offering better digestive health is key for any weight loss product, but Bio X4’s correlation to the latter may be weak. We looked at all facets of this product to provide you with the synopsis found here.

Bio X4 can be purchased through their Official Site.

Bio X4 Readers: Noom is offering our readers a free trial, for a limited time. Click here for this special offer!

What is Bio X4?

Bio X4 is a weight-loss probiotic supplement. The company behind Bio X4 claims the 4-in-1 weight management probiotic helps you:

  • Take control of your appetite
  • Manage food cravings
  • Boost metabolism and digestion
  • Feel better than ever

Who Makes Bio X4?

Health and wellness manufacturer Nucific developed Bio x4. Bio X4 isn’t the only supplement from Nucific; the company also researches, develops and distributes a range of nutritional supplements, including:

Nucific products do not contain preservatives, synthetic fillers, antibiotics or food coloring. Also, the supplements are 100% natural. An independent third party facility lab-tests the potency and quality of ingredients in Nucific products, including Bio-X4.

California recognizes Nucific as a green-friendly company using only renewable energy and recyclable materials.

Nucific Company Profile

Nucific is a Better Business Bureau accredited company with an  “A+” rating.

The goal of the company is to offer “cutting-edge” supplements supported by science. The fundamental principles of Nucific are:

  • Potent Ingredients
  • Quality Testing
  • Earth-Friendly
  • California-Made

Nucific maintains public visibility and communication with customers and health enthusiasts by providing educational videos and nutritional information on their official website. It’s important to note that Nucific donates a portion of proceeds from every purchase to Action Against Hunger.

Dr Amy Lee, board-certified in internal medicine, sits on the Board of Directors. She also plays a major role in the development of Nucific products, and is an active member of the health community.

Dr Amy Lee’s Three Harmful Foods

Dr Lee made a video discussing three harmful types of “healthy foods” not banned by the FDA, including:

  • Yogurt with added sugars
  • Wheat bread
  • Cereal bars

Bio X4 Ingredients

Bio X4 relies on four-ingredient blends to potentially support better digestion, control food cravings, increase energy and promote weight loss. The formulas include a:

  • Probiotic blend
  • Digestive enzyme blend
  • Weight management blend
  • Craving control blend

Probiotic blend

Lactobacillus Blend:

By taking 3 capsules per day, you cumulatively ingest 39 billion CFUs.

  • L. Acidophilus
  • L. Rhamnosus
  • L. Plantarum

Bifidobacterium Blend:

  • B. Lactis
  • B. Animalis

Digestive Enzyme Blend

  • Amylase (from Aspergilus Oryzae)
  • Bromelain
  • Lipase (from Rhizopus Oryzae)

Weight Management Blend

  • Green tea extract (50% EGCG)

Craving Control Blend

  • Caralluma Fimbriata Extract

There’s research presented supporting the effectiveness of some key Bio X4 ingredients.

Caralluma fimbriata extract is a wild cactus plant grown in India; containing chemical compounds supposedly helping control appetite.

Research presented in the journal Perspectives in Clinical Research examined the relationship between caralluma fimbriata supplementation, safety, and weight control. The group using caralluma did show a slight decrease in BMI.

According to the journal Appetite, “Caralluma extract appears to suppress appetite, and reduce waist circumference when compared to placebo over a 2 month period.”

Bio X4 Nutrition Facts

Each serving of Bio X4 is one capsule, with one bottle containing 90 capsules or a one-month supply.

Each Bio X4 capsule contains:

  • Probiotic Blend – 4 billion CFUs (colony-forming units)
  • Digestive Blend – 43mg
  • Weight Management Blend – 100mg
  • Craving Control Blend –  166mg

The capsules are 100% gluten-free and do not contain any common allergens.

Does Bio X4 Work?

Bio X4 is formulated to provide gastrointestinal tract support by supplying beneficial gut bacteria. This, in turn, may help optimize health and promote weight loss. According to research in the journal Nutrients, probiotics may help restore “good” bacteria in your body and balance bacteria levels.

Bio X4 ingredients such as green tea may increase energy and metabolism.

Ingredients like caralluma fimbriata may suppress appetite. Through increased metabolic rate, boosted energy levels and curbing appetite, Bio X4 may help users feel better and lose weight.

Benefits and Results

Bio X4 Results

As with most nutritional supplements, the longer you maintain usage on a daily basis, the greater the results you may see. The manufacturer recommends maintaining a steady daily regimen and, if you happen to miss a day, do not try to make up for the dose; simply take the recommended dose as per usual.

As for seeing peak results, the manufacturer states you should be able to evaluate its max performance for you in 60 days effectively. Of course, instructions specify you have to take the capsules on a daily basis to maximize results.

The company states as long as you keep working out and avoid eating sweets, you should be able to see results within a couple of months of taking the product.

Bio X4 Side Effects

Nucific states there is no known side effect and that it is safe for most adults.

While this may be true in general, it is important to note that anyone considering this supplement should read the nutrition label carefully to make sure none of the ingredients will trigger an allergic reaction (for those with certain food allergies). Always read the product label carefully and stick to the recommended dosage.

Pros and Cons

Bio X4 Pros & Cons


  • Promotes optimal digestive health.
  • The manufacturer offers package deals.
  • Improves bowel regularity.
  • Enhances immune system health.
  • Supports higher energy levels.
  • Gluten-, allergen-, and lactose-free.
  • 90-day money-back guarantee.
  • Eco-friendly packaging.
  • Third-party lab tests.
  • Transparent about board members and their qualifications.
  • Useful health blog on the official website.


  • Expensive for some.
  • You must take it on a regular basis to experience maximal effects.
  • Some users may have trouble remembering to take the capsules three times a day.
  • Only available online.

Ultimately, it’s up to you and your healthcare provider to determine which the best weight control nutritional supplement is for you.

Bio X4 Alternatives

There is indeed a wide array of dietary probiotic weight control supplements on the market, so much so that it can be an anxiety-inducing experience even to begin to research them all. To help you narrow your search for the right supplement, here are a few guidelines to keep in mind when deciding whether Bio X4 or an alternative is right for your needs.

Always purchase from a reputable manufacturer or another vendor, and look for the GMP (Good Manufacturing Practice) certification to ensure a quality lab produced the product.

Always look for quality ingredients but also a balance of additives that you know to work well in combination.

Bio X4 alternatives include:


Bio X4 Price

Fortunately for committed Bio X4 enthusiasts, the manufacturer offers not only single bottles for sale but also two additional multi-purchase promo offers to help users stock up and save.

Bio X4 prices on the official website include:

  • One bottle (30-day supply): $99
  • Three bottles (90-day supply): $297
  • Six bottles (180-day supply): $594

These prices may vary based on internet sales.

Aside from the original manufacturer, prices per bottle will vary. If you aren’t going to purchase from Nucific directly, make sure to read all company policies carefully as well as reviews associated with the vendor. Nucific offers a 90-day money-back guarantee on Bio X4 purchases.

Are There Any Bio X4 Specials?

Each Bio X4 purchase from the original manufacturer comes with a 90-day money-back satisfaction guarantee.

The first Bio X4 package deal offers the discounted price of $129 for three bottles, a price the manufacturer claims reflects a $168 savings. The second and top-tier package deal offers six bottles of Bio X4 for $240 – a savings of over $350.

Customers can also enter a coupon code at checkout for further savings, depending on the available promotions at the time of sale.

Where Can I Buy Bio X4?

Because this weight-loss supplement is fairly new to the market, it is not available in stores at this time. Anyone interested should purchase it directly from the manufacturer to ensure authenticity and freshness.

Always do your research when considering a vendor. Again, read all company policies closely as well as any reviews associated with the company.

Bio X4 Directions

Per product instructions, users are to take one Bio X4 capsule with each meal. This includes breakfast, lunch and dinner, for a total of three capsules daily.

You may take up to two capsules per meal, but do not take more than six in a day.

By supplementing with each meal, the pills are designed to support digestive processes with fewer tummy troubles and potentially even greater nutrient absorption.

Daily supplementation, according to claims, may lead to greatly enhanced digestive health as well as faster weight loss.

What Users Are Saying

“Tried this product for several months with no improvement to digestive problems.”

“Seems to be working, I’m losing weight.”

“Some days I feel like I’m getting a boost of energy and other days I don’t. I’ve read wonderful things about this. Not really losing weight, this is my 2nd bottle but I think I’m done taking it. Not good, not bad either.”

Bottom Line

The Bottom Line on Bio X4

There is little doubt that Bio X4 is a popular nutritional probiotic and weight control supplement among consumers. Most of its ingredients have a historical, worldwide use for weight loss and health. We also like that Nucific is a trusted brand offering a 4-in-1 supplement promoting health and wellness.

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Bio X4 Review

Bio X4

Does Bio X4 help you lose weight?

No, Bio X4 is not made specifically for weight loss, though probiotics can help with gut health and overall body health.

What are Bio X4 ingredients?

Bio X4 ingredients are L. acidophilus, L. rhamnosus, L. plantarum, B. lactis, B. animalis, amylase, bromelain, lipase, green tea extract and Slimaluma (caralluma fimbriata).

What does Bio X4 do for you?

There’s a connection between Bio X4 and weight-management. The four-in-one formula also promotes digestive health.

How should I take Bio X4?

You take one capsule before each meal.

How long does it take to see the effects of Bio X4?

It can take between 30 and 60 days to see results from Bio X4, but some users have noticed results sooner then that.

Where can I buy Bio X4?

Bio X4 can be purchased using their Official Site.

Does Bio X4 come with a guarantee?

Yes, there is a 90-day money-back guarantee with your Bio X4 purchase.

Does Bio X4 contain caffeine?

Since Bio X4 contains 100 mg of green tea in each serving, there will be slight traces of caffeine in the product.

Is Bio X4 vegan?

Although Bio X4 is not vegan, it is vegetarian, lactose-free, and gluten-free.

28 Bio X4 Reviews

  • Anonymous

    Does this have any animal product inside of it for example gelatin from pigs?

    • Montana (Editor)

      Bio X4 does not contain any gelatin.

  • Again, Shelf LIfe?

    What is the shelf life for Bio X4? Did not see a reply to that question and I am wondering the same thing.

    • Montana (Editor)

      Bio X4 does not specify a shelf life for their supplements, but each bottle should have a clearly labeled expiration date.

      • kim

        hello where can i find the expiry date on my bottle? I don’t see it…

        • Montana (Editor)

          A manufacture or expiration date should be labeled on the bottle or cap. If Bio X4 doesn’t mark this on the bottle, we suggest contacting Nucific for more information.

  • Shelf life
    Howard Maculsay

    What is the shelf life of Bio X4

  • Anonymous

    Can u take this if u have thyroid problems?

  • Possible SSRI interaction.
    Julie Smith (Verified Purchase)

    Don’t take if you use an SSRI. May interact and cause negative effects. Nucific declines to release research on this matter stating it was confidential. I wouldn’t trust them.

  • I like it but my doctor doesnt.
    Joyce Walker (Verified Purchase)

    I’ve taken BioX4 for three months now. I have problems with occasional diverticulosis. The product appears to control my bowels causing me to not experience any diarrhea. However, my gastrointestinal specialist advises me not to take it because of the lack of regulation and one item in the product that she’s not aware of.

    • Ewa

      Which item.? I have the same problem
      Thank you for sharing your experience 🌹
      Also I have high insulin level ( insulin resistance) and hoping that will be good for me to try
      Thank you

  • Bio X4 and Kidney Health

    Is Bio X4 good for people with all stages of kidney disease?

    • Angelica (Editor)

      Hi Crystal,

      We do suggest that you consult with your physician if you have any pre-existing conditions or are worried that a product may conflict with a medication

  • Richard Ligotti (Verified Purchase)

    I tried Bio X4 in August 2017, I do not recall seeing any meaningful results. Just watched the video of Dr. Lee, very impressive; than I checked my emails to see if I ever tried this product and sure enough there was the order confirmation in Aug. 2017. If it had worked i would have continued purchasing it. It is amazing how convincing the product videos can be. I did not bother, taking advantage of the money back offer.

  • Megan

    If I was to start taking Bio X4 does that then mean that I would have to take it for the rest of my life to maintain a steady and healthy weight ? Or do I stop after I’ve reached my desired weight and take it every now and then instead of everyday ?

    • Janie Whitehead

      I didn’t see the answer to a question if i take the Bio x4 if I do loose weiight, will i have to take the pills the rest of my life.?

  • Angela

    can I take bio x4 while pregnant?

    • Larry

      Ask your doctor! Believe no one else…

    • Anonymous


  • Moriba

    Can I take this if i have high blood pressure and diabetes

    • Anonymous

      Can this product be taken if Inhqve high blood pressure

      • Montana (Editor)

        We suggest consulting with your doctor to see if this product is safe for you.

  • I forgot to take it before my meal.
    Bonnie Johnson

    I forgot to take it before my meal. Should I take it while I am eating or just skip it?

    • Victoria (Editor)

      Hi Bonnie! The product label currently states that “whenever you are about to eat, simply take one capsule of Bio-X4 beforehand. Then, enjoy your meal!”. So, it might be best to just re-start fresh tomorrow since you forgot to take the product today.

    • Maxine

      It’s says take it with meal so before or after is probabaly okay.

      • Larry

        I would say, before or during.. not quite sure about after.

    • BJames

      The directions on the bottle say it should be taken WITH each meal, not necessarily before a meal. I usually take it after I’ve had a few bites of my meal.

    • Hope

      Just watched dr. Lee’s video and she specifically stated just before you eat your meal.
      Remember, not everyone reacts to any supplement or medicine the same way.