Updated: 02/14/2017 - Site operated by Leptigen
By Summer Banks Jan 20, 2017

97% of dieters are just looking for a product that works. Yeah, we’re wondering about the other 3%, too. We took a close look at Bio X4, checking on the ingredients, side effects, clinical research and customer service. We found hundreds of comments and read through them all. Then, we condensed and summarized to give you the bottom line.

Bio X4 Readers: Click here to find out why we're giving away samples of our product, Leptigen.

What You Need to Know

First off, Bio X4 is a probiotic often used for weight-loss. It contains a Lactobacillus Blend, Bifidobacterum Blend, Digestive Enzyme Blend, green tea extract and Slimaluma (caralluma fimbriata). You take one capsule with each meal and one bottle lasts a month. You don’t have to worry about carting this one around, it’s portable.

Nucific, the company that makes Bio X4, started online in 2015. You can buy directly from the official website and there is a savings if you buy multiple bottles. We like the effect of probiotics on the digestive system and there’s some green tea in the mix, but read on…

Side Effects – “What Are You Feeling?”

The first thing we considered was Bio X4 side effects. “We found quite a number of reports of things like gas and bloating,” said our Research Editor. “The confusing thing is, that’s one of the things the product is supposed to fight.”

"Almost immediately after starting BIO X4, I developed very frequent loose stools with a lot of gas," said a customer.

"Took one with breakfast and now I feel jittery and edgy," offered another.

On the flip side, some users experienced the opposite.

"No bloating and very little [gas] from a person who was full of it everyday," one customer said.

Another offered, "If I take it correctly, I do not get indigestion."

Customer Service – “Where Are They?”

One of the most important things a company does for customers is answer questions. We’re not sure how that’s going to happen if no one can contact them. As one user said, “I phoned yesterday and was on hold for about 5 minutes before a recording came on and said I could leave my number and a customer service person would phone me back. No call back.”

One also said, “I have already sent 3 emails to support@nucific.com for the past 2 days & no word for them whatsoever. I find that strange.”

We didn’t find any customers that had something positive to say about the support they received from Nucific.

Over the years, we’ve found it takes a small thing, like poor customer service, to stop any chance of long-term results. If Bio X4 representatives don’t support the caller, eventually they’ll turn to another company.

The Science – “Any Real Proof?”

At DietSpotlight, we want to see science before we can recommend any product. We looked for research into Bio X4 ingredients, but we were disappointed. Sure, green tea is strong and it will help boost metabolism, but it also costs about $5 at your local pharmacy. If we can’t find anything else connecting it to weight-loss, why bother?

Also: read our Leptigen Weight-Loss Kit review »

The Bottom Line – Does Bio X4 Work?

Are we getting in the car right now to head out for Bio X4? Well, we like the idea of adding probiotics to your diet and some users may notice positive changes to digestion, but we are hesitant to recommend it for weight-loss because there’s just no proof it will work. Plus, we’re concerned that the customer service department is not there when users need help.

If you’re at the point you want to lose those extra pounds, we suggest going for a product that’s made with 100% clinically proven ingredients. You also need a company that’s there for customers when they need help.

Among the best products we’ve seen this year is one called Leptigen. There are four ingredients in the mix and all have been scientifically proven to help spark metabolism and fat loss, which can lead to weight-loss. There are no reports of negative side effects, and we looked. What is out there are some amazing experiences.

Plus, if you’re looking for a deal, Leptigen comes with a Special Trial Offer, because the company is confident you’ll like the formula.

Bio X4 Questions & Answers:

We narrowed down hundreds of reviews and experiences on Bio X4 into this helpful FAQ.

What are the side effects of Bio X4?

Bio X4 side effects may include gas and bloating, according to customer reviews.

What are the ingredients in Bio X4?

Bio X4 ingredients are L. acidophilus, L. rhamnosus, L. plantarum, B. lactis, B. animalis, amylase, bromelain, lipase, green tea extract and Slimaluma (caralluma fimbriata).

Does Bio X4 work?

If you’re looking for some connection between Bio X4 and weight-loss, the only one is via the green tea. None of the other ingredients are clinically proven to help you lose.

You may want to switch things up and change out Bio X4 for a supplement that is clinically proven, like Leptigen.

How much does Bio X4 cost?

You can buy a one-month supply for $49. Three months is $129 and six months is $240.

What is Bio X4’s BBB rating?

We found no Better Business Bureau (BBB) rating for Bio X4 or Nucific, the company behind the product.

How should I take Bio X4?

You take one capsule with each meal for a total of three a day.

Can I take Bio X4 if I have a health condition?

You may be able to, but we suggest talking with your doctor, especially if you are pregnant, nursing, trying to become pregnant, taking prescription medications, have a health condition or are under 18 years of age.

What do users like about Bio X4?

Bio X4 users tend to like the positive effects on digestion. We also found some who appreciated the guarantee.

What do users NOT like about Bio X4?

On the flip side, some Bio X4 users did not like the gas and bloating they experienced when taking the supplement. The price was also an issue for some.

Should I buy more than one bottle of Bio X4?

According to the Bio X4 website, customers often purchase 3 bottles at a time. You save 12% if you order that number.

How long does it take to see the effects of Bio X4?

It can take between 30 and 60 days to see results from Bio X4.

Is weight-loss guaranteed with Bio X4?

Interestingly, the FAQ section of the official website does address this. According to Bio X4, “if you are taking the recommended serving of 3 capsules on a daily basis, exercising regularly, and not overeating carbs and sweets, you will start seeing results within the first 1-2 months.”

How do I contact Bio X4 customer service?

You can call Bio X4 customer service at 1-888-679-5520 from 5 am to 7 pm Monday to Friday or 6 am to 4:30 pm Saturday and Sunday. Write to Nucific 19528 Ventura Blvd. #343 Tarzana, CA 91356. If you like email contact, send your message to support@nucific.com.

Does Bio X4 come with a guarantee?

Yes, there is a 90-day money-back guarantee with your Bio X4 purchase.

Do you know of any specials or deals for Bio X4?

Yes, the website claims you can save money with multiple-bottle purchases. The maximum you can save is 18% if you buy 6 bottles at once. However, what really interests us is the uptick in readers taking advantage of Leptigen’s Special Trial Offer, which is just the cost of shipping and handling. Click here to give it a go.

Get Your Sample Today »
About the Author:

Summer Banks, a content strategist at Leptigen, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 3.5. From 8 votes.
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User Comments

6 Comments on "Bio X4 Review"


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can I take bio x4 while pregnant?

Hi Angela! For detailed product and usage instructions, please refer to the Bio X4 official website for more information if it is safe to consume during pregnancy.

I was taking this product and started to have Atrial Flutter so the doctors have told me I cannot take it due to the green tea in it (it will interfere with the Coumadin/warfarin that I have to take. It also creates a blood pressure issue for me.

Can I take this if i have high blood pressure and diabetes

This product does contain stimulants, which can run the risk of increasing blood pressure in dieters. Be sure your doctor gives you the ok to take this product.

Your Name Joan Whittemore

I am not sure but I have been constipated since taking it,
and the caffeine is keeping from sleeping. I have only taken it a few days and will try it a few more days and then I may return for a full refund. Thank you.