Update: - Advertising Disclosure

Plexus ProBio5 Review - 16 Things You Need to Know

Plexus ProBio5 is a daily probiotic supplement. It claims to promote optimal gut health. However, the clinical dose appears to be less than what’s recommended according to research. When a supplement’s ingredient isn’t at a clinically-effective dose, chances are, it won’t be effective. So, our research team set out to find ProBio5’s benefits, if any, and potential side effects. Then, we compiled our research into the bottom line.

Plexus ProBio5 can be purchased through their Official Site.

Plexus ProBio5 Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Plexus ProBio5?

Plexus ProBio5 is a blend of enzymes and probiotics formulated to support healthy digestion.

The colony-forming units come from five probiotic strains; Bacillus coagulans, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus plantarum, and Saccharomyces boulardii. There is also an enzyme blend, B-complex vitamins, and other natural ingredients (such as grape seed extract).

Do you feel dull and energy-deprived all the time? Do you think that you are not getting enough sugars from your foodstuff?

Do you suffer from constipation and diarrhea every now and then?

Plexus ProBio5 may just be what you need. Its ingredients come from natural sources.

Along with that, the only element other than these organic components is water.

No additives and fillers are added to it to help stabilize the probiotic components of the supplement. You don’t have to refrigerate it as well.

That said, ProBio5 may still be lacking in some aspects.

For example, the label recommends taking between one and four capsules each day with a meal or before going to bed. Four may be excessive for some and with four capsules a day, it can get expensive.

What does research have to say about this product? Let’s take a quick look at the studies surrounding this supplement’s ingredients:

Plexus ProBio5 Competitors

Other similar products: Plexus BioCleanse, Plexus Slim
How Did It Start?

How Did Plexus ProBio5 Start?

Probiotics have been part of numerous research for many years. Its efficacy has only improved over time.

Plexus Worldwide is well known for its nutritional supplements available in the market. They are also well known for being a multi-level marketing company.

One of their bestsellers, ProBio5, a probiotic supplement, has been a favorite go-to supplement because it is gluten-free and it comes with a money-back guarantee.

Though its effectiveness is not guaranteed, there have been no harmful side effects reported.

Plexus ProBio5 Customer Testimonials

Plexus ProBio5 and the BBB

Plexus has earned an “A+” rating with the BBB and a 3.6 out of 5 stars, based on an average of 204 customer reviews. They’ve closed a total of 124 complaints lodged with the BBB in the past 36 months – 24, of which, were closed in the last year.


Plexus ProBio5 Claims

Per official website, ProBio5 “helps keep intestinal yeast in balance, helps support a healthy intestinal tract, supports healthy digestion, helps improve natural response to imbalance, promotes healthy bacteria counts and pH levels in the gut, aids in digestion, it’s a good source of antioxidants and it contains vitamin C which supports immune function.”

Weight loss is not one of its benefits though. None of the ingredients present in ProBio5 are known to aid in weight loss.

Plexus offers a 60-day money back policy.

In case you are not satisfied with the product, you can exchange it or return it and get your money back provided that the product is in its original packaging.

A limit of 15-60 days is how long you have to get your money back. Plexus ProBio5 has gained a lot of customer trust and satisfaction due to their money-back guarantee.

Update 2022: Plexus Worldwide is one of six companies to receive warning letters from the FTC regarding health claims and the coronavirus.


Plexus ProBio5 Ingredients

The main ingredients present in the Plexus ProBio5 are the proprietary enzyme and probiotic blends and grape seed extract.

These components help promote a healthy gut environment for efficient digestion.

A healthy GI tract has very positive impact on your body, including your skin, heart, and mental health. Here is a detailed insight into the main ingredients that make up Plexus ProBio5:

Bacillus Coagulans

Bacillus coagulans is a spore-forming bacterium, according to Foods. It is said to have numerous beneficial effects on the digestive and immune functions of the body.

It also neutralizes the intestinal flora, which gets upset during diarrhea.

It can help prevent infections associated with Helicobacter pylori, such as Enteritis and Gastritis. It also helps in preventing and treating Clostridium difficile and colitis infections.

This bacteria is generally considered safe to consume, per Food and Chemical Toxicology

Bifidobacterium Longum

Bifidobacterium longum is a member of the Bifidobacterium family. It acts as a probiotic, which can boost food decomposition and digestion rhythms.

It also enhances nutrient absorption from the gut. Weight loss management is another good prospect offered by Bifidobacterium longum.

It has a considerable post-antibiotic effect, so it can remain in the intestinal flora even if its dose is discontinued.

Lactobacillus Acidophilus

Lactobacillus acidophilus is a bacterium that is quite well known for its transformation of milk sugars into lactic acid, which happens during food decomposition processes.

It is, therefore, used to improve lactose tolerance in people who have lactose intolerance issues. It also reduces the episodes of abdominal pain, gas, or bloating. Lactobacillus acidophilus also helps in the screening of harmful pathogens in the intestinal flora.

The bacteria has been shown to have therapeutic effects, according to the North American Journal of Medical Sciences

Lactobacillus Plantarum

Lactobacillus Plantarum is the ideal probiotic which is used to suppress Escherichia coli infections, according to BMC Microbiology. It takes an active part in speeding up the body’s natural food decomposition patterns. It is also useful for lactose intolerant and sensitive individuals.

It has antioxidant and antimicrobial properties.

It improves intestinal permeability, increases the absorption nutrient from the gut, and decreases microbes’ growth for healthy intestinal flora.

Saccharomyces Boulardii

Saccharomyces boulardii is a widely used probiotic enhancer. All this is due to its digestive and immunity enhancing abilities, according to Therapeutic Advances in Gastroenterology.

Saccharomyces boulardii works on the colonies of the microbes and tries normalizing bowel motility.

Enzymatic Blend (proteases, chitosanase, cellulase, serrapeptase)

Enzymes are the proteins that are naturally occurring in the body. They catalyze numerous reactions and substances during digestion as well.

These responses then cause the food particles to be broken down and absorbed into the blood as antioxidants, nutrients, vitamins, etc.

For example, the enzyme proteases are used for the protein decomposition. Similarly, chitosanase is used to transform glycosidic bonds into oligosaccharides.

On the other hand, it is shown that serrapeptase reduces the formation of blood clots which is useful for CVS patients.

It also has anti-inflammatory responses. It aids in stomach digestion and healing over time.

Vitamin C

It is also known as ascorbic acid, according to the U.S. National Library of Medicine. Vitamin C is known to increase and boost metabolism. It also helps in increasing the absorption of the nutrient.

It is a wonderful antioxidant for the body’s cellular setup. This vitamin can be taken in by eating various vegetables and fruits mostly the citrus ones.

This supplementation can easily help in reducing common cold, can affect cardiovascular health, and is beneficial for reducing the symptoms of cataract.

Vitamin B6

Vitamin B6 is an essential part of the B-vitamin complex. It plays a role in the enzymatic metabolism of many lipids, amino acids, and glucose-based components.

It helps with nausea during the early stages of pregnancy.

Vitamin B6 also helps relieve PMS symptoms.

Grape Seed Extract

Grape seed extract has countless health benefits.

The antioxidant effect of grape seed gives better health levels which leads to the reduction of PMS symptoms.

It blocks the enzymes that damage other essential enzymes like elastase and collagenase.

Grape seed extract is utilized in normalizing bowel movements and immunity screening as well. Testing is currently being done by the Clinical Nutrition Research Center to determine its benefits for blood pressure.

Does It Work?

Does Plexus ProBio5 Work?

Plexus ProBio5 is a supplement that aids in digestion and has effects on the intestinal flora. It has a blend of probiotics that actively participate in neutralizing the pH of the intestine.

This supplement helps efficiently balance the acidity of the stomach.

Although no medical proof has been found about this supplement’s effectiveness, reviews suggest that it works to some extent.

No potential side effects were noted, so it is relatively safe to use. However, you must check with your doctor before use if you have any medical or underlying condition.


Plexus ProBio5 Benefits and Results

The main benefits that Plexus ProBio5 offers are listed below. Most of the benefits are related to the effects that Plexus ProBio5 has on the intestinal flora. Although there are speculations of its impact on weight loss, there are no substantial proof about it from any clinical trials.

  • It aids in keeping the intestinal yeast in balance to neutralize the intestinal flora.
  • It helps in maintaining and supporting a healthy intestinal tract.
  • It also assists in making the process of digestion faster and more effective.
  • It helps in countering the acidity of the stomach and improving its natural response.
  • It promotes growth and increases the presence of healthy bacteria in the stomach.
  • It aids in maintaining pH levels in the gut.
  • This supplement is rich in antioxidants.
  • Each capsule contains 2 billion CFU.
  • Composed of active probiotics which act as protectants of your intestines.
  • Comprised of healthy and beneficial enzymes blend that is employed in improving digestion.
  • Comes with a 60-day money-back guarantee.
Weight Loss

Details on Plexus ProBio5 and Weight Loss

Plexus ProBio5 contains several ingredients but none of them are known to help with weight loss. Some user reviews reported weight loss in conjunction with a healthy diet and regular exercise.


How to Use Plexus ProBio5

Plexus ProBio5 comes in a bottle of 60 capsules. Per official website, “Adults take 1 capsule daily at bedtime. Up to 4 capsules can initially be taken at bedtime until desired results are achieved.”

It’s best to consult with your doctor before you start taking any supplement especially if you are pregnant, breastfeeding, have an underlying condition, or taking other medication.

Side Effects

Potential Plexus ProBio5 Side Effects

Potential side effects from ingredients are:

  • Serrapeptase may interfere with blood clotting so it may make bleeding disorders worse in some people.
  • Allergic reactions from probiotics.
  • Headache, muscle and joint pain are possible.
  • Bloating, gas pain and nausea are also common.
Product Warnings

Plexus ProBio5 Product Warnings

  • Not recommended for use by individuals under 18.
  • Check with your doctor prior to use if you are pregnant or nursing.
  • Do not exceed the recommended daily dose.
  • Do not use if the safety seal is broken.
  • If you are taking other medications, consult with your doctor to prevent harmful drug interactions.
  • Keep out of reach of children.
  • Check the best before date.

Plexus ProBio5 Lawsuits

We found multiple lawsuits and complaints against Plexus Worldwide – over the top health claims, product safety issues, deceptive earnings claims, unauthorized charges.

In 2014, the FDA issued a warning letter to Plexus Worldwide based on claims made on their website that the products Fast Relief, ProBio5 and BioCleanse “are intended for use as drugs”.

In 2020, they also received a warning letter from the Federal Trade Commission regarding “Health Claims Related to Coronavirus Disease 2019 (COVID-19)”.


Plexus ProBio5 Alternatives

Alternatives for ProBio5 include:

  • Vitamin Bounty’s Pro 50 Probiotic with 13 Probiotic Strains, 50 Billion Organisms per serving
  • Hyperbiotics Organic Prebiotic Powder – promotes the growth of good bacteria
  • PRO-Bifido Probiotics – support for Ages 50+ (Bifidobacterium) 15x
  • Douglas Laboratories Multi-Probiotic 40 Billion – provides probiotics and prebiotics
Contact Info

Plexus Contact Information

  • Address: Plexus Worldwide® 9145 East Pima Center Parkway Scottsdale, Arizona 85258
  • Phone: 480-998-3490
What Users Are Saying

What Users Are Saying

“I think Probio5 is beyond amazing. Healing my gut and changing the way I felt. Creating a healthy balance inside my body so that I had more energy and felt great.”

“Made me really sick.”

“Don’t waste your money. This probiotic isn’t better than any others. It’s pricey and it doesn’t bring anything that a $12 bottle can’t do.”

Plexus ProBio5 Ingredients
Bottom Line

The Bottom Line on ProBio5

So, will ProBio5 help you lose weight? Well, we like it contains a few natural ingredients and that we found some favorable customer comments, but we’re hesitant about this one because there’s no connection between the formula and weight-loss. We’re also concerned about the high price tag and negative side effects reported by customers.

For dieters ready to shed those extra pounds, we suggest going with a weight-loss app that’s setting the standard in user support.

Among the best weight-loss apps we’ve seen is Noom. This app doesn’t offer cookie-cutter suggestions – you get real human coaching, customized meal plans, food tracking, exercise tracking and much more. All this and it’s clinically proven to help you lose weight and keep it off, for good.

Dietspotlight readers can access a free trial offer of Noom for a limited time.

Learn More About Noom »
Plexus ProBio5 Review
Plexus ProBio5 Customers Also Bought:
Free Trial Offer
Explanation of Chart
Garcinia Cambogia
Caralluma Fimbriata

Plexus ProBio5

What is Plexus ProBio5?

Plexus ProBio5 is a probiotic supplement. It claims to help balance the intestinal system.

What are the side effects of Plexus ProBio5?

As reported in customer reviews, Probio5 side effects may include itchy skin, sleeplessness, irregular bowel movements, diarrhea, upset stomach and abdominal pain.

What is in Probio5?

Probio5 ingredients are protease, chitosanase, cellulase, serrapeptase, bacillus coagulans, lactobacillus acidophilus, bifidobacterium longum, lactobacillus plantarum, saccharomyces boulardii, grape seed extract, gelatin, water and brown rice powder.

What are the active ingredients in Probio5?

The active ingredients in Probio5 include protease, chitosanase, cellulase and serrapeptase.

Does Probio5 work?

We found no scientific research proving Probio5 is an effective weight-loss supplement. There are studies suggesting the benefits of probiotics, but the research doesn’t point toward this formula.

Where can I buy Plexus ProBio5?

Plexus ProBio5 can be purchased using their Official Site.

How much does a bottle of Probio5 cost?

$46.95 (One-time purchase)

$46.95 (then $42.26 after 3 months)

How many Plexus ProBio5 should I take?

You should take one to four Probio5 capsules with an evening meal or prior to sleep. Each bottle contains 60 pills, lasting anywhere between 15 days and two months.

Who makes Probio5?

Plexus Worldwide makes Probio5.

Is Probio5 gluten-free?

Yes, Probio5 is gluten-free.

Has the FDA ever contacted the makers of Probio5?

Yes, the FDA has contacted the makers of Probio5 in July of 2014 due to misleading claims.

Does Probio come with a guarantee?

Probio5 comes with a guarantee. For a full refund, you will need to return the supplement within 60 days.

When should I take Plexus ProBio5?

Users can take ProBio5 in the evening with your dinner or before you go to sleep.

Is Plexus ProBio5 vegan?

ProBio5 is not vegan, but it is gluten-free.

48 Plexus ProBio5 Reviews

  • Product
    Jean Holt (Verified Purchase)

    Have been on the Tri-System a week. Feel very bloated, excess gas & abdominal pain. It almost feels like a diverlutsis attack. It this comom when oNE is getting a good gut? Jean

  • Rizzo (Verified Purchase)

    Can this help with constipation

    • Montana (Editor)

      Hello Rizzo. There is some scientific studies that supports the use of probiotics to relieve constipation.

  • How do you cure the diarrhea??
    Agatha (Verified Purchase)

    I took one pill a day for a week while the diarrhea has gotten worse. I stopped the ProBio5 a week ago and there has been no change in the diarrhea. Have I destroyed my gut with five pills? I’m told that it changes your gut’s reaction to certain foods.

  • mary welden (Verified Purchase)

    would like to order Probiotic 5

  • Lin

    i havebwanted to try this but not sure why u need to take a cleanse daily if u are regular already?

    • Just

      Probiotics aren’t a “cleanse.” They’re healthy bacteria that are supposed to be good for your small intestine, helping everything from digestion to mood (since many neurotransmitters are actually produced in the gut). But the science is still out on proven results. I’m not sure why this is marketed as a weight loss supplement, because there’s no proof probiotics have anything to do with increased metabolism. I’ll tell you one thing though, it’ll give you some strange and vivid dreams.

      • Leah

        I’ve never had strange or Vivid Dreams on this. But It has only been a week that Ive been using it.

  • Cindy

    Why do I feel bloated.

    • Maribel (Editor)

      Hi Cindy, sorry to hear you feel bloated. If you continue to feel this way it might be best to see a doctor, and make sure this product is right for you. If so, maybe Dietspotlight Burn, users haven’t reported significant side-effects with this product.

    • Leah

      Ive been using this a week now and have noticed some bloating also but I can tend to do that from time to time. When I used Plexus slim alone for a 1 week trial I lost 5 pounds (water weight I think) and was feeling slim and healthy. Now I’ve added the Pro bio 5 and bio cleanse and see no difference. I’ve gained weight and feel bloated and fat! I will say this however, to knock a product down just because results vary is wrong. (You didn’t do this but other threads I’m seeing.) everybody is different so what works for some may not work for others. I’m giving this a month or so but if I see no change then I’m done. Its too expensive.

  • Pamela

    Probio5 is a terrific! It contains an antifungal and Chitosonase, an enzyme which breaks down the outer shell of Candida yeast. It also begins breaking down where it is needed, in the small intestine. As far as cost, it is actually comparable or cheaper than many on the market now. Also-if you go online and look at milk tests for probiotics, which shows their efficacy, and look up tests with Probio5, you’ll see it actually does what it says. In addition, Plexus has done double-blind, independent research on Triplex (Slim/Biocleanse/Probio5) which can be found on the website. Last, Biocleanse has many benefits, but one of them is to flush out the toxins that Probio5 has destroyed. The company is all about getting your insides healthy. Weight loss is a by-product of that process, IF that’s what you need. Anyone can benefit from improving gut health and blood sugar balance.

  • Kyle

    i was suffering from EXTREME IBS-D. After taking this product along with the bio cleanse ALL symptoms are gone. I feel human again. I no longer have to take ANY medication to stop diarrhea. It is amazing and i have had zero negative side affects. You have to try this, especially if you suffer from ibs-d!!!

  • Heather

    What if you have someone who regularly gets yeast infections, wouldn’t the probio5 help with this?

    • Veronica

      Hi Heather! For detailed product and usage instructions, please refer to the ProBio5 official website to learn more if this can help you.

      • Michelle Beeuwsaert

        Yes it will. I take the triplex which includes the probio5. I was getting them all the time, plus I have Crohn’s and sleepless nights and now I noticed a big difference in my sleep…I’m able to stay asleep longer. I love these products I wish I had been told about them years ago.

  • Aaron

    Probio 5 works great with killing Candida, I plan to stay on for a year until my overgrowth is completely gone.

    • How long did it take for you to see results for killing your Candida overgrowth? I might have Candida overgrowth and have severe acid reflex because of it. I just got plexus in the mail so I’m hoping it helps me to

      How long did it take for you to see results for killing your Candida overgrowth? I might have Candida overgrowth and have severe acid reflex because of it. I just got plexus in the mail so I’m hoping it helps me too.

  • Your NameLiza

    Plexus works! Everyone has an opinion to knock new things on the market becaue maybe they dind’t work for them! I have been constipated for years! With Plexus Probio5, I go twice a day now, along with biocleanse and slim! My husband has also lost 20 pounds in 30 days and I have lost 10! Down now to my original size 4! Nothing in the past had worked for me for the pat 6 years: NOTHING! I started taking these three things and viola! Don’t knock it if it doesn’t work for you. It has helped now litterally thousands of people.

  • Marlo Name

    Been 3 weeks now – feeling full, bloated and very gassy this last week. I drink lots of water. I am thinking tonight was my last pill. This is not making me feel good.

    • Gabby

      it made me fell that way the first two weeks but now I feel much better. I think it was my body readjusting to something good

    • Maribel (Editor)

      Hi Marlo, so sorry to hear you have experienced negative side-effects with Probio 5. If these results continue might be a good idea to see your doctor or check out another product that could work for you. An idea is Dietspotlight Burn. See how it goes, it does have encouraging reviews.

  • Angela

    I have been using Plexus products now for about 11 months. I love the Probio5. I haven’t been sick, not even a sniffle. I go regularly now. I have been taking 3 at night before bed and I think everyone needs to be on it. Gut health effects your over all well being. Drinking half my weight in water, (oz’s) has also helps the Probio5 work.

    Ashley Wilson (Verified Purchase)

    I have been using Probio5 since October 2015. I love this product. Yes I had some of the icky side effects but if you take a probiotic you should feel that for the first bit. Those icky side effects is telling you that it is killing that bad bacteria which is trying to fight to stay. The candida that probio5 is killing off survives on sugar so if you are taking probio5 and eating sugar until you get the yeast under control you will have yucky side effects. If you eliminate sugar, get your probio5’s up to 4 stay at 4 for a week and then return to 2 your sugar cravings and icky side effects will be gone and you will feel so much better.

  • Kristin

    Probio5 is an amazing product. Four days wont even begin to touch the years of candida overgrowth and who knows what else that’s in your gut. Furthermore, anybody taking probio5 needs to be taking BioCleanse as well. The two products work hand in hand and have helped some of my closest friends who have suffered from tummy troubles their whole life!

    • Cinda

      Exactly what does this product do? These comments are kind of vague and I would like to see clear information on why someone should take it and if it’s for everyone? Is this something that is long term? Why would anyone need to use the BioCleanse if they are not ever constipated? Would the BioCleanse be fore occasional cleansings? How affordable is it? I haven’t seen any pricing. Look forward to seeing answers to my questions. Thank you.

      • Adrian (Editor)

        Hi! For detailed product and usage instructions, please refer to the Probio5 official website for more information.

      • Moe

        I will tell you why you need both. Because probio5. Gets rid of all that nasty stuff in your guts. Well.. .after all that nastiness is killed off…it needs 2 be properly be flushed from your body. That’s where biocleabse comes in.

        • Marcel Rioux

          Do you only take biocleans after your done taking bio5

  • Lost 16 pounds in 6 weeks !
    Laura (Verified Purchase)

    I have been using this for 6 weeks. I have lost 16 pounds. I started taking just one now a take two a day. I like it

    • Your Name

      Do you take it by itself or with the cleanse

  • It has cleared up a lot of gas !
    Frances (Verified Purchase)

    I have been taking Probio5 for about weeks, when I take more than one I have a lot of stomach pain. It has cleared up a lot of gas, and loud gut noise that I had. I’m concerned about taking it with antibiotics.

    • Stephen (Editor)

      Ask your doctor before adding the antibiotics. Gassy build up is sometime reported.

    • Angela

      Make sure you are drinking a lot of water. It makes a difference.

      • Your Name

        The gas and bloating could be caused by the candida die

  • It is not a stand alone product
    Your Name (Verified Purchase)

    Its a tool to help your gut become healthy, which assists in weight loss. It is not a stand alone product for weight lose. But if you are in the market for an excellent probiotic, you won’t find a better one!

    • Lori

      I happen to be a major fan. Tell us your thoughts about Probio5. I’ve seen it work miracles. It has been amazing for my depression. Even though that may sound unbelievable. It makes me sad that a site like this would try to sound so official, yet try something for four days and give a review. This single product has given hope to more people than I can count. And this is my first time to ever get on a site like this and offer my opinion.

      • NotPhat_JusPhluffy

        I LOVE Probio5! Been taking for 6 weeks & I am Finally regular & sleeping better than I have in 20 years. I rise early, between 5-8, and fal asleep by 10-midnight, which is great for me! I started Plexus hoping to lose weight but that hasn’t happened yet. That’s ok tho, I’m 100% satisfied with the other perks I am getting.

    • Your Name

      I love it. It works best with plexus biocleanse. Probio 5 is like cleaning your toilet and the biocleanse is like flushing the toilet.

      • Leah

        Great analogy! 🙂

      • Tabatha Schreiber

        I have been taking probio5 for a week and I haven’t gone number two in days!! I’m so bloated I barely eat! It’s very uncomfortable!!! I just ordered the bio cleanse now Leary if I should even start that?????? HELP!!!!!

    • Your Name

      I have a week taking it and make me sleepie the next day.

  • this was a suprise
    heidi (Verified Purchase)

    I have been taking probio5 for about three weeks now with the Biocleanse and I’ve gone to the washroom more regularly than normal. I feel that it is helping since I actually took the product simply to get healthier, not so much to loose weight. I am already quite slim but what I did find is that my waistline lost about an inch or perhaps a bit more and I wasn’t even looking for that result…….happy however that it happenend. We all try hard to shed unwanted lbs….this was a suprise.

  • It works great for your intestinal tract
    Tina (Verified Purchase)

    Probio5 is THE best probiotic on the Market! I have been taking it for almost 3 years! It works great for your intestinal tract!! Used with the BioCleanse and it’s even better!!!

    • Adam

      Can you tell me how many cfu’s per serving pro bou 5 offers? Intrested to know. Also how ma y strands of strains does it offer? Thank you!!!

      • B

        It literally tells you all of that in the article above.

      • Mandy Wiedeman

        It has 5 stains and there are 2 million per capsule. Serving size is 1 to 4 capsules

Load More