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Plexus BioCleanse Review - 14 Things You Need to Know

Plexus BioCleanse is a detoxifying supplement claiming to “flush out the digestive tract to get rid of harmful toxins.” The company also states the capsules promote weight loss, but the science was scarce. In fact, some users of this product have reported gaining weight, not losing it.

Our research crew found reports of other unpleasant side effects during their investigations, including nausea, dehydration, and diarrhea. We had to get to the bottom of this supplement, so we investigated every aspect of Plexus BioCleanse to give you the nitty-gritty on this internal cleanser.

Plexus BioCleanse can be purchased through their Official Site.

Plexus BioCleanse Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Plexus BioCleanse?

Plexus BioCleanse is promoted as a cleansing and detox supplement for flushing out the digestive tract, promoting weight loss, and removing harmful microbes and toxins from the body. The research will tell you the body does a perfectly fine job removing toxins, but that doesn’t stop supplement companies from selling supplements for this reason. It is 100% vegetarian and contains no artificial colors, flavors, preservatives, or gluten. This product is one of the numerous health and weight loss supplements available from Plexus Worldwide. The Plexus BioCleanse ingredients include:

  • Sodium – 50mg
  • Magnesium – 380mg
  • Ascorbic Acid (Vitamin C) – 150mg
  • Bioflavonoid Complex – 50mg
  • Rice Flour
  • Hypromellose (vegetarian capsule)

Both sodium and magnesium are important electrolytes that help balance fluid and water levels in the body. They also help prevent dehydration, regulate healthy pH levels, transport nutrients into cells, aid with bodily functions, and remove toxic waste from cells. Other electrolytes include calcium, phosphate, chlorine, and potassium.

These minerals should help prevent dehydration while taking Plexus BioCleanse. Even though this supplement is taken with water, internal cleansing products tend to pull a lot of water from the body, leading to dehydration in some cases. Some experts do not encourage the use of these types of supplements for this reason.

When we took a brief look at the research, we found:

  • Journal of Dietary Supplements – Drinking plenty of water is imperative when taking this product, or any internal cleanse supplement. The reality is these supplements can dehydrate the body. They can also cause electrolyte imbalances and lead to diarrhea, which is a common side effect.
  • Journal of International Medical Research – Magnesium hydroxide may be more efficient than a bulk-laxative when treating constipation in some elderly patients, offers research.
  •  International Journal of Cosmetic Science – The University of Maryland Medical Center states vitamin C is a potent antioxidant; and necessary for growth. Vitamin C also helps the body make collagen, a crucial protein needed for skin, tendons, cartilage, blood vessels, and ligaments.

Plexus and the BBB

Plexus has been accredited by the BBB since December 29th, 2019. They have an “A+” rating with 3.6 stars out of 5 based on an average of 102 customer reviews. There have been 64 closed complaints in the last three years with 13 in the last 12 months.

Customer Service Information

You can contact Plexus BioCleanse by phone or fill out a contact form.

Address: Plexus Worldwide® 9145 East Pima Center Parkway Scottsdale, Arizona 85258 U.S.A. Cross streets- 90th Street and the Loop 101

Phone: 480-998-3490 (English) and 480-374-4998 (Español)

Hours of Operation: U.S. and Canada: 5:00 AM – 5:00 PM MST (Monday-Friday), 6:00 AM – 3:00 PM MST (Saturday), and Sunday Closed

Contact form: https://helpcenter.plexusworldwide.com/hc/en-us/requests/new

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Plexus BioCleanse Benefits

Let’s take a closer look at the benefits of Plexus BioCleanse. Here is what the official website claims for this Plexus supplement:

  • Promotes regularity
  • Reduces gas, bloating, and discomfort
  • Helps cleanse the gastrointestinal tract
  • Relieves occasional constipation
  • Removes harmful microbes
  • Aids with natural detoxification

However, you can get similar benefits from foods in your diet. Eating the right foods for healthy digestion and regularity makes more sense because it’s a long-term effect instead of a quick fix that won’t last.


How to Take Plexus BioCleanse

Taking Plexus BioCleanse is relatively simple. You take two capsules with eight ounces of water each day, in-between meals, or in the evening. You are not instructed to follow a particular Plexus diet plan. There is no regular exercise mentioned with this cleanse supplement.


Plexus BioCleanse Ingredients

We need to focus on the core ingredients in Plexus BioCleanse to understand how to works. Here is a breakdown of this formula.

Bioflavonoid Complex

These are citrus bioflavonoids (sometimes called Vitamin P) taken from the fruits, lemons, grapefruit, and quince. Per Pubmed, the vitamin has quite a complicated chemical structure.

They are semi-essential nutrients (potent antioxidants) and are sometimes used in dietary supplements to help some health conditions, according to the Journal of Pharmacy & Pharmacology

Plexus BioCleanse Ingredients

Sodium Bicarbonate

Commonly known as baking soda, this chemical compound is used in cooking, a cleaning agent, personal hygiene, and even medical purposes. It is a combination of bicarbonate ions and salt ions. This ingredient is found in a wide array of dietary supplements as well.

Sodium bicarbonate can help reduce stomach acid. It’s often used as an antacid for treating issues like heartburn, upset stomach, and indigestion. Sodium bicarbonate is also described as a fast-acting antacid, but it should only be taken in moderation for temporary relief, says DailyMed.

Magnesium Hydroxide

This is a naturally occurring mineral that is crucial for proper nerve and muscle function. Sometimes this substance is used for constipation, heartburn, and indigestion, according to the U.S. National Library of Medicine. It assists in reducing stomach acid levels and increasing the amount of water in the colon.

Ascorbic Acid

Also commonly known as vitamin C, this ingredient is often in manufactured foods, cosmetics, and dietary supplements. Vitamin C naturally occurs in oranges, lemons, bell peppers, kale, broccoli, and tomatoes. It is imperative for overall health and wellness, according to the National Institutes of Health.

Rice Flour

A finely ground powder made from rice is often used as an alternative to wheat flour and to manufacture supplement capsules. However, it’s an inactive ingredient and not intended to improve health.

Side Effects

Plexus BioCleanse Side Effects

According to BioCleanse Plexus reviews, this diet product may cause some unwanted side effects. However, you should note this is likely related to this formula’s ingredients, rather than the product.

Plexus BioCleanse Side Effects

The potential side effects are:

  • Upset stomach
  • Diarrhea
  • Weight gain
  • Dehydration
  • Headache
  • Nausea
Pros & Cons

Plexus BioCleanse Pros & Cons


  • There is a 60-day money-back guarantee
  • Customers can purchase economic combo packs
  • The formula is all-natural
  • Plexus Worldwide is an established, international company
  • Plexus BioCleanse is affordable
  • The formula has many health benefits


  • Ingredients are not explained well
  • Clinical test data is not cited

Plexus BioCleanse Reviews and Customer Feedback

There are all sorts of Plexus reviews around the web for Bio Cleanse pills. Some of which you can find on Amazon and the official website. These customer comments are both positive and negative, and while others are neutral.

As far as Plexus BioCleanse results are concerned, the website does not mention how long it takes to see noticeable effects from this cleanse and detox supplement. However, some users said results (mainly with constipation relief) within the first week of taking this product.

Where to Buy

Where Can I Buy Plexus BioCleanse?

The supplement can be purchased directly from the official Plexus Worldwide website.

You can also buy this product from dealer websites such as eBay and Amazon.


Plexus BioCleanse Price

A one-time purchase (single bottle) is $46.95 for 180 capsules. But you have the option of subscribing as well, which will save you 10% by maintaining an active monthly subscription. This makes each bottle $42.26 after 3 months, which they send to you every 30 days.

If you buy Plexus BioCleanse from the official website, there is a 60-day money-back guarantee. Note this only applies to one bottle.

MLM Opportunity

Plexus Worldwide

Plexus offers a multi-level marketing (MLM) plan allowing customers to earn money by promoting and selling Plexus products as Ambassadors. They have an extensive Compensation Plan on its website detailing its Ambassadors’ requirements and rewards for selling Plexus products.

However, the Plan specifies to be a “Qualified Ambassador” and “earn points, bonuses, and commissions,” customers must have a paid and current annual membership and “have at least 100 in Personal Volume (PV), excluding Welcome Pack PV, through the monthly cycle end date.”


Plexus BioCleanse Alternatives

Here are some alternatives to Plexus BioCleanse pills. These supplements are also used to clean and detoxify the body, flushing out the colon, and relieving digestive issues.

  • Vitamin Bounty Pro 50 Probiotic
  • Dr. Tobias Colon 14 Day Quick Cleanse
  • Super Colon Cleanse
  • Bio Schwartz 15-Day Fast Acting Colon Detox & Cleanser
  • Plexus ProBio 5

Be aware these products are not for long-term weight loss. While some claim to help you drop some pounds, this weight is typically waste from the colon. Plexus BioCleanse is not specifically for fat loss, appetite suppression, or boosting metabolism. Therefore you shouldn’t expect any weight loss while taking this detox and cleansing formula.

Studies have shown intestinal cleansing can disrupt good bacteria in the digestive tract and lead to impaired bowel function, which can do more harm than good, says the Journal of Dietary Supplements. 

The National Center for Complementary and Integrative Health found detox and cleanse products may actually be unsafe, depending on the ingredients.


Other Plexus Weight Loss Products

Plexus offers several other products for weight loss and weight management. Here is a closer look at these supplements.

  • Plexus Slim
  • Plexus Block
  • Plexus Lean
  • Plexus Active
  • Plexus MetaBurn
  • Plexus Balance
  • Plexus Hydrate

Plexus Slim is a powder formula you add to water and consume one to two times daily. It aims to promote weight loss, elevate good bacteria in the gut, boost metabolism, improve overall health, and support healthy glucose metabolism.

Other Plexus Weight Loss Products

Plexus Block is a carb-blocker supplement you take with water before meals. It helps prevent the body from absorbing up to 48% of the sugars and carbs you consume. Plexus Accelerator+ is a capsule supplement you take daily between meals. It assists by boosting metabolism and burning off more fat. When combined with diet and exercise, it helps promote weight loss.

Plexus Boost supposedly helps reduce appetite. This way, you eat fewer calories throughout the day, which can help with weight loss and weight management. Plexus 96 is a protein shake that comes in vanilla and chocolate flavors. It provides 15 grams of protein and more than 20 vitamins and minerals to build lean muscle, reduce food cravings and boost energy levels. This product is used in place of snacks and meals to help you cut calories. It only contains 100 calories per shake.

What Users Are Saying

What Users Are Saying

“I buy BioCleanse on a regular basis.”

“Didn’t do anything for me.”

“I’ve been using this product for years and if I’m off it for even a day, my body knows. Great product. Highly recommend.”

Bottom Line

The Bottom Line on Plexus BioCleanse

Plexus BioCleanse is a dietary supplement from one of the leading MLM companies in the industry. The supplement offers some researched ingredients and some noticed results. However, when it comes to overall wellness, this isn’t the only option. While some science points toward natural solutions for detoxing the body; there’s the option of navigating toward a healthy diet, exercise and taking the right supplementation.

Weight management comes in multiple forms with digestive health playing a major part. While Plexus BioCleanse offers digestive support, there are alternatives you can incorporate into your weight management plan, including weight-loss apps.

We’ve looked at countless weight-loss apps and one catching our attention is Noom. Research supporting the program shows it can help users lose more weight. But, what’s even more important is that the support system behind the app can also help users keep that weight off – no more yo-yo weight gain.

Also, the team behind Noom is offering Dietspotlight readers a free trial offer for a limited time.

Learn More About Noom »
Plexus BioCleanse Review
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Plexus BioCleanse

What are the side effects of Biocleanse?

Users report Biocleanse side effects may include diarrhea, nausea, upset stomach, and stomach pain.

What are the ingredients in Biocleanse?

BioCleanse ingredients include vitamin C, magnesium, sodium, and a bioflavonoid complex (orange peel, lemon peel, quince whole fruit).

Does Biocleanse work?

While some people reported success with BioCleanse, we weren’t able to locate any published science to support it as an effective weight-loss supplement.

How much does Biocleanse cost?

A 180 capsule bottle is $46.95.

How should I take Biocleanse?

Take two capsules with a full glass of water, twice a day, between meals.

Where can I buy Plexus BioCleanse?

Plexus BioCleanse can be purchased using their Official Site.

Do you have to join Plexus to buy?

No. You do not have to join the business opportunity to buy products. You can place an order online without a consultant.

Does Biocleanse come with a guarantee?

There is a 60-day satisfaction guarantee. Return the product within 60 days for a full refund.

Is Plexus Biocleanse safe?

According to the official website, “Plexus meets or exceeds all regulatory standards and guidelines for product safety and efficacy.”

Can you take Biocleanse and ProBio5 at the same time?

You can take Biocleanse and ProBio5 at the same time. In fact, you can take them together before bed, according to the product directions.

48 Plexus BioCleanse Reviews

  • not satisfied
    Carolyn (Verified Purchase)

    i’ve been on plexus almost 3 months. I have not gotten the results i was looking for. I wanted to lose 10 pounds. Instead I gained 6 pounds…….

  • M. Carole McConnell

    Can you take bio Cleanse with heart meds?

    • Summer Banks FNS, SPT

      Hey there. You’ll have to talk to your medical provider about that Carole. Have a great day!

  • Yep! It definitely Works
    Melanye Narcarti (Verified Purchase)

    Never, Ever take BioCleanse before bed, unless you want to be up and in the bathroom half the night!

  • Not good
    Carmen Sandu (Verified Purchase)

    Did not work for me as it gave me anxiety

  • Side Effects
    Joa (Verified Purchase)

    I guess I am a rare person who has the side effect of diarrhea. It has been a problem for more than a week. Mainly after I eat. If this continues I will have have to stop this product.

  • How long can I use this?
    Rick C (Verified Purchase)

    I have had a candidate problem for 7 months. One month ago I started bio clense & a probiotic. I want know how long can I take the bio clense?

    • Darlene

      Rick you need to get with your ambassador 🙂

    • Maribel (Editor)

      Hi Rick ! Please make sure to consult with your physician to know how long you can take this product.

  • Cory

    I am a 24 year old male and have been using a combo of the BioCleanse, ProBio5, and the Plexus Slim Packets for a little over 2 weeks. I started this to just be healthier, I am 6ft and was 194 lb’s and am now 173 lb’s. I cut all soda and coffee out and only drink water, I stopped eating fast food and do my best to say no to sweets. I am sure it is a combo of the plexus and diet change that caused the weight loss but I can’t really be certain. I feel really good and energized through the day BUT food does basically run right through me and it did kind of freak me out. I feel good though honestly aside from that side effect.

    • Maribel (Editor)

      Hi Corny, thanks for keeping us informed on your process with Biocleanse. Another alternative to consider is Dietspotlight Burn. It will help you burn fat, lose weight and boost energy. Good luck!

  • Sandi

    I have concerns about the Sodium Bicarbonate in this capsule. What is the function of that in this medication? is this Sodium like salt? I wouldn’t think it would be a healthy amount to be taking every day.

    • Anonymous

      Sodium Bicarbonate is basically baking soda. It is found in many other dietary supplements, and is a great ingredient to have to reduce stomach acid. So its used as an antacid as well.

  • Ashley

    BioCleanse has helped so much since I started taking it, along with the ProBio 2 months ago. I did experience a “Herxheimer reaction” (toxin die off) the first week or two, but since then it’s been great. I have IBS-C and haven’t had any episodes in the time I’ve been taking the BioCleanse. I’m overall very happy with the product.

    • Elizabeth Grant

      Do you take the biocleanse 2x a day or 1?

  • Juli C

    I was very skeptical prior to trying Bio Cleanse (also the ProBio). At first I was bloated and had gas but it stopped after a week. Important to drink a lot of water. It has been a month now and my BM are more regular. Suffering with IBS/ constipation can be miserable at times. I also feel “good” and have more energy/alertness. Since I also started using a collagen supplement about a week after starting the Bio Cleanse, I am not sure which one is making me feel so good but I am sticking with it. I have not lost any weight but I did not start taking it for that reason so it doesn’t matter to me.

    • Amy S

      I also suffer with constipation. I’ve been taking both the bio cleanse and pro bio for about a week now. I can’t tell a huge difference just yet. Am I being too impatient?

  • Michelle H

    Bio Cleanse is helping my BM movement, but my goodness it makes my urine spell awful, even if I drink enough water

    • Maribel (Editor)

      Hi Michelle. Sorry to hear. If this persists, you might want to consider another product. Maybe Dietspotlight Burn, it will help you burn fat and it delivers fast weight-loss results.

  • Denise (Verified Purchase)

    I use bio cleanse and I love it. The side effect of lose stools is caused by the magnesium in it. Taking 2 pills will have that effect. It can also cause the stomach upset. I have to take magnesium for my heart because it helps strengthen my muscles. I also have migrantes which the magnesium in the bio cleanse stops the migraine . Not all magnesium is the same and not absorbed by the body but for me bio cleanse is absorbed.

  • Joanne Whitley

    experiencing some stomach pain side effect from bio cleanse & probio5. I take 2 of each every night. So what will help those side effects… Do I need to reduce my intake of each or just the bio cleanse?

    • Kristi

      You shouldn’t be taking these at the same time. Probably why you’re having side effects. Bio cleanse should be taken mid morning and mid afternoon. Pro bio should be taken before bed. I have never taken them at the same time and never had a side effect. Been on them for 2+ years. My consultant specifically warned me not to take them too close together bc it could cause side effects.

      • Elizabeth Grant

        I have been taking the biocleanse and probio together for years with no side effects. Maybe it doesn’t have to do with them being taken together. I know some say not to take them together and I started that way and others love taken them together

      • Anonymous

        I did not know this. I been taking both at bedtime

        • Debbie

          I tale Biocleanse in the morning and Probiotic at bedtime. Has really helped me

  • Don Kirby

    I have used the product for over a month. I am pleased. I have droprped almost 5% body fat.
    If you buy from an educated ambassodor they will tell you to drink at least half your body weight of water in ounces. Water is extremley important. It is not a magic pill. It is a supplement. You still have to eat a healthy diet and exercise.

  • Ricky P

    i am using the Plexus Slim and the bio cleanse. The Bio cleanse has given me extreme abdominal pain in the pancreas area. I mean extreme. The ” Pink Drink” by itself give me no abdominal pain. I had my gall bladder removed about 3 years ago. Very painful. The pro bio gave me the same symptoms.

    • Adrian (Editor)

      Hello. All users are different and can experience different results; please make sure to consult with your physician before continuing this product to make sure its safe and effective for you to use.

    • Shannon

      I also have no gull bladder and I’ve been on the plexus slim , bio cleanse , and pro bio 5 for 2 years now and no problems like cramping . Can I ask how much your on of each product ? I would suggest getting with your ambassador and asking there suggestion . It could be a detox your going thru

  • Mark

    I don’t know about the plexus one but I did the Bio Cleanse Detox Kit, which has the same name but is different. It was exceptional.

  • Save your money & eat clean!
    Dena (Verified Purchase)

    I have taken the pink drink, bio cleanse and the probiotics now for three months and I have stopped taking them all because I have been way more blotted and in pain in my upper abdomen then I ever was before. For a year before trying this I was eating and drinking a 75% raw vegan diet( dealing with some serious health problems) and was SO MUCH better off health and feeling wise then in the past three months. I do know a few people who these products work for but for me and a few others who I have heard say the same as what I have been dealing with they DON’T. Save your money and just for goodness sakes eat CLEAN, your body will thank you for it.

    • Kevin

      I’ve been taking it now for 5 days. I’ve also been having bad upper abdominal pain. Also feeling nausea.

    • Sandy

      I started taking in March and have tried all kinds of combo of taking it it didn’t help me it seemed to make me feel bad and have nasuea,stomach pains,feel bloated and the noises my stomach makes were terrible. I have been afraid to leave my house it seemed to make me have that sense of needing get to go but can’t then all of a sudden I have to go right then or else . I stopped two days ago and I already feel better. Still drinking the pink slim but will probably stop that also its just too expensive for a retired fixed income lady .

  • Its not a diet product !

    First of all, BioCleanse is not a diet product. It is only meant to help with better gut health.

    • Your Name

      Amen!!! I’ve been a plexus ambassador for a little over a year now … Im a plant based vegan and was for 7 months before trying plexus I use what we call the Triplex combo, slim Bio Cleanse and ProBio5 I feel better than I have in years
      All my menopause symptoms are gone and so is all the inflammation from my body … we are not a diet company and these are not magic pills
      I’m sure you can find negative information about any product on the market… If you have a good ambassador they will help you figure out what products are best for you and how to use them as we are all different ????

      • Becky Nord

        I’ve been taking Biocleanse and ProBio5 for 3 years now. I weighed 170 when I started taking them, lost 55 pounds and have maintained 115 for 2.5 years now. I experienced the diarrhea in the beginning but my ambassador helped me adjust the biocleanse to lessen the discomfort. It’s just a matter of sticking with it and getting through the initial negative side effects. This has been a gamechanger for me! 🙂

  • NO wonder this makes you loose weight
    Scott Boss (Verified Purchase)

    BIO Cleanse, the worst pills I’ve ever taken !!! I took 2 pills once a day for four days ten days ago, not only does it make me blotted, I’ve been puking and pissing out my ass for seven days now. I stopped taking this four days now and I’m Still up at 3 am pissing out my ass, stomach just rolling, dehydrated, and up all night because of this product, can’t believe at all this crap can be good for me !!! NO wonder this makes you loose weight, no matter what you eat it comes out at one end or the other. I’m 6ft. Tall and 175lbs
    I don’t need to lose weight, my wife bought cause I have stomach problems. Now my stomach problems are worse than ever b4!!!

    • Jackie

      I’ve had the same issue! Not throwing up but the diarea is out of control! I haven’t taken it for 4 days, but have had it for almost 2 weeks! Please tell me it gets better!!

      • Anna (Editor)

        Hi Jackie. Please make sure to consult with your physician before continuing to take this product and let them know about the side effects you were experiencing.

        • Jaqueline

          I too, tried 1 bio clense and 1 pro bio before bed per my ambassadors advice, and have had CHRONIC diarehha, cramps, nausea, fatigue, body aches since. I felt great before just wanted a little boost on weight lose after my baby a year ago. It’s been a week since it all started and haven’t touched the stuff since the first time and I’m still ill. Doctor appt. In the a.m to see if I can get some help. My ambassador told me it was candida. ..but the worst she’s ever heard of…sounds like a lot people are have the same effects.

          • Linds

            I have IBS and i have been taking 3 at night with my probiotic but in the last 2 weeks i have had diarrhea cramping and i was wondering what to do.i have been on this for a year but never had this issues till.2 weeks ago

    • Tom

      I take strong prescription pain medicines and the side affect is terrible constipation. I have taken stool softners and eaten prunes trying to help it and then I started taking Bio Cleanse. I started taking 2 in the morning and 2 at night until I had to run to the bathroom, then went to just 2 in the morning. It has kept me regulated like nothing else has been able to do. I had to take laxitives often also but still got locked up every couple months and had to use enemas and suppositors to help break it loose. Taking 2 Bio Cleanse every morning and drinking water has kept things regulated completely. I can’t say enough about how it’s helped me and I do recommend it to anyone with chronic constipation problems.

      • Kim

        I agree! It has helped my tremendously with my ibsc. I’ve been on it for four years now. I’m wondering if it is okay to use long term like this? All I know is that I was so constipated all of the time until I started this . It’s been a godsend.

    • Holly E

      Not sure how long ago you posted this, but I have to question whether or not you were getting advice from an ambassador plexus? Were you only taking the bio cleanse? Diarrhea should never be as serious as you’re claiming yours to be. Were you drinking plenty of water? Recommended water intake is half your bodyweight in ounces. Mmm mmm

      • Charlotte

        Several years ago, I showed the product to my doctor, He looked at the magnesium and said, ” Oh wow, that would make you go, that is a lot of magnesium!” My cardiologist told me not to take more than 250 mg a day. Bio Cleanse gave me diarrhea as well. My husband cannot take it because of the grapefruit, which is not listed in all materials. We were ambassadors one time.

      • Anonymous

        I drink over a gallon of water a day and I cannot leave my home because of the diarrhea. No matter what I eat it comes back out in less than 10 minutes. Absolutely ridiculous.

    • Kellie

      I’m so sorry but I literally cannot breathe from laughing so hard reading this comment. I am experiencing the SAME AWFUL THINGS!! I do not understand how this can be legally sold. I need butt paste. I too, bought it for gut health. This is absolutely ridiculous.

      • Anonymous

        I too am experiencing the worst liquid diarrhea I have ever had. I’m on day 10 of taking the triplex combo and omg. All I am
        Told is that it’s normal. This is not normal. I can’t leave my house and am in the bathroom everyone 10 mins. I can’t sleep, eat or do anything. I might have to go to the walk in for iv fluids.

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