Lipo-6 is original fat-burning pill produced by Nutrex and has sold so well that Nutrex now produces a number of Lipo-6 derivative products. The company assures users that Lipo-6 will deliver “accelerated fat loss.” But it’s worth mentioning that the primary ingredient in Lipo-6 is Synephrine HCL, which has had decidedly mixed results in clinical studies. While some people have lost weight under medical supervision using Synephrine, others have lost no weight while experiencing severe side effects such as jitters and nausea.
Is Lipo-6 the right fat-burner for you? Read on to learn what our research team found out about the product, and decide for yourself.
Lipo 6 can be purchased through their Official Site.
Lipo 6 Video Review
What is Lipo-6?
For starters, Lipo 6 is marketed as maximum strength, rapid weight loss aid that promotes energy and focus. This dietary supplement is touted as an “accelerated fat-loss formula” and comes in the form of fast-acting liquid-caps. The product aims to target stored body fat, break it down, and burn it off to promote healthy weight loss. Its fast-absorbing ingredients are pharmaceutical-strength and free of animal components. Put simply, Lipo 6 is claimed to burn off fat quickly, but does science agree?
Products Similar to Lipo 6
How Did Lipo 6 Start?
Lipo 6 first showed up back in 2005 and is made by Nutrex Research, Inc. It is part of their Basix Series of supplements, and it was formulated to be the world’s first liquid capsule diet pill.
This product is geared toward men, women, bodybuilders, and fitness enthusiasts alike.
There are now several options to choose from, which include:
- Defining Gel
- Black Nighttime Ultra Concentrated
- Black Training Pre-Workout
- Keto goFat Gel
- Black Keto
- Black Stim-Free
- Black Diuretic
- Black Ultra Concentrated
- Black Hers Ultra Concentrated
- Black Intense
- Black Hers
According to the official website, “It is no wonder that LIPO-6 was voted ‘Fat-Loss Support Product of the Year’ in 2005, 2006, 2007 and 2008.”
How to Contact Lipo 6 – Nutrex Research
579 South Econ Circle
Oviedo, FL 32765
- Toll Free: 888-3Nutrex (888-368-8739)
- Phone: 407-359-0734
- Fax: 407-971-1459
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Lipo 6 Claims
Okay, let’s take a closer look at those marketing claims for Lipo 6 pills. Here is what this diet supplement offers:
- First liquid capsule diet pill ever
- Fast-absorbing liquid capsule technology
- Accelerated fat loss effects
- Rapid and healthy weight loss results
- Pharmaceutical-strength ingredients
- Natural vegetarian capsules
- 4-time award winner for fat loss
Lipo 6 Ingredients
Now for an in-depth look at Lipo 6 ingredients to get a better understanding of what this formula has to offer. It contains the following:
Caffeine Anhydrous (200mg)
A dehydrated form of caffeine that is sometimes used in medications, pharmaceuticals, and dietary supplements. It works the same as caffeine and has stimulant effects. Caffeine comes from natural sources such as tea leaves, coffee beans, cacao pods, and kola nuts.
Synephrine HCl (20mg)
An alkaloid that is found in bitter orange (also called citrus Aurantium). It has similar effects to ephedrine and is often used in diet products as a fat burner. Like caffeine, it has stimulant effects, but some studies have shown that it may be unsafe.
Also called Piperine, this is an extract from black pepper. Aside from being used as a food spice, it is often added to supplements because it has been shown to help with the body’s absorption of various nutrients, according to EODMT.
Synthetic 99% Guggulsterones Z&E 1:1 (20mg)
A human-made version of guggulsterone, which comes from the Guggul tree that claims to have some health benefits. In animal studies, guggulsterone “influenced obesity-related factors,” says the Journal of Dietary Supplements
Yohimbine HCl (3mg)
This is an indole alkaloid that comes from the Pausinystalia Yohimbe tree, indigenous to Central Africa. It has been shown in some studies to improve blood flow.
Does Lipo 6 Work?
This is the question you need answering. Does Lipo 6 work as claimed? Let’s focus our attention on the key ingredients and what documented research has to say.
According to research published in Nutrition, caffeine does have beneficial effects, at least when consumed in moderation.
Studies have shown that it can help boost energy levels, reduce fatigue, improve athletic performance, enhance alertness and concentration, improve focus, and help with cognitive function.
According to the International Journal of Medical Sciences, “p-Synephrine alone as well as in combination products were shown to increase resting metabolic rate and energy expenditure, and modest increases in weight loss were observed with bitter orange extract/p-synephrine-containing products when given for six to 12 weeks.” Guggulsterones (Guggul) may help stimulate metabolism and might improve overall weight loss results.
Bioperine or piperine has demonstrated the ability to improve ingredient or nutrient absorption, which in turn helps boost product effectiveness. It is considered a bioavailability enhancer, says Current Opinion on Drug Metabolism and Toxicology.
While yohimbine has been shown to improve blood flow, which may help with erectile dysfunction, athletic performance, and weight loss.
Lipo 6 Benefits
The benefits of Lipo 6 fast-acting liquid capsules are said to include rapid fat loss and serious weight loss results.
We took a closer look at Lipo 6 reviews to gain a better understanding of what actual users had to say.
In short, there are a lot of mixed opinions on this maximum strength fat loss formula.
While some users reported better energy, and some mentioned weight loss, others complained about side effects such as dizziness, headaches, and lightheadedness.
It is worth it to take some time and read through the user feedback and customer comments for this diet product, so you get a better understanding of what others have experienced and what Lipo 6 results they have seen.
You can find Lipo 6 reviews on the official website and dealer sites such as Amazon.
Details on Lipo 6 and Weight Loss
What about actual weight loss effects? Can you count on Lipo 6 to help you safely drop some pounds, or is this diet product a scam?
The Journal of the American College of Nutrition concluded synephrine taken in combination with caffeine could help increase lipolysis and fat oxidation.
A study published in the British Journal of Pharmacology concluded yohimbine might have both thermogenic and lipolytic effects.
How to Take Lipo 6
By now, you are probably wondering how I can use Lipo 6?
Well, according to the packaging, the recommended use for fat loss is to take two liquid-caps 30 minutes prior to breakfast and two more in the afternoon.
However, it is recommended to begin with only one liquid-cap each morning and afternoon, at least for the first two days, in order to adjust to this supplement.
It is important to never exceed four liquid-caps of Lipo 6 in a single day. Also, you should not take this product within 6 hours of bedtime.
Potential Lipo 6 Side Effects
The overall safety of Lipo 6 is a concern. We took a close look at the ingredients in this supplement, as well as the customer reviews posted online, and here are the possible Lipo 6 side effects you could experience:
- Stomach irritation
- Sleeping issues
- Rapid heartbeat
Caffeine is a stimulant. It is often found in coffee, tea, and soda. It has also become a popular ingredient in many weight-loss supplements. Caffeine is commonly consumed to increase mental alertness.
According to Medicine and Science in Sports Exercise, “The additional 22% reduction in body weight, 25% reduction in epididymal fat-cell size, and 5 and 6% reductions in epididymal and retroperitoneal fat-pad weights, respectively, in the caf-ex group beyond the no caf-ex group support the hypothesis that fat loss with aerobic exercise can be increased when caffeine is ingested prior to the training sessions.”
Performance during the 45 min energy-based target time trial was significantly faster (∼5.0%) for the caffeine group and the coffee group in comparison to the decaf and placebo (38.35±1.53, 38.27±1.80, 40.23±1.98, 40.31±1.22 minutes p<0.05).
These substantially faster times were mirrored in both the caffeine as well as the coffee groups. The average power for the caffeine and coffee groups throughout the time trials were substantially better in comparison to the decaf and the placebo groups (294±21 W, 291±22 W, 277±14 W, 276±23, p<0.05).
There were no important alterations noticed between the placebo and the decaf groups during the time trials. In conclusion, both caffeine and coffee (5 mg/kg/BW, 5 mg/kg/BW, respectively) ingested 1 hour before exercise could enhance endurance exercise performance, as per PLoS One.
Also known as bitter orange, synephrine has become a popular ingredient in many supplements since ephedrine was banned by the FDA. It is considered a stimulant and is used heavily in the dieting sector. Synephrine is used to help with poor appetite, weight loss, fatigue, and more.
In a study published in Experimental Biology and Medicine, researchers tested the effects of synephrine in weight-loss supplements. They concluded, “There is little evidence that products containing C. Aurantium are an effective aid to weight loss.”
Bitter orange by itself or mixed with other products proved to elevate resting metabolic rate as well as energy expenditure, and mild elevations in weight-loss were noticed within the p-Synephrine products when administered for 6 to 12 weeks.
Guggulsterones have been consumed historically for weight loss, acne, and more. According to the Journal of Dietary Supplements, “Guggulsterones at the dose of 400 mg/kg body weight was able to significantly reduce food intake and limit body weight gain over a period of 15 days.”
Both subjective, as well as objective criteria were taken into account regarding the efficacy evaluation of Yohimbine.
The subjective principles included improved sexual desires, frequency of sexual contacts, sexual satisfaction, and erection quality during intercourse.
The objective principles of outcome were based on penile rigidity improvement, which was studied via polysomnography within the sleep laboratory. In conclusion, Yohimbine’s response rate was noted to be substantially more effective than the placebo (71 versus 45%).
It was found that yohimbine was very well tolerated, with only 7% of subjects rating their tolerability at fair or poor. Most of the negative effects reported were mild, and there were no significant adverse effects reported, as per the International Journal of Impotence Research.
Lipo 6 Product Warnings
There is a long list of Lipo 6 warnings posted on the bottle label. These include the following:
- Not suitable for people under the age of 18.
- Do not take if you are pregnant or nursing a child.
- Never exceed the recommended dosage.
- Do not consume other sources of synephrine or caffeine while using Lipo 6.
- Do not use this supplement for more than eight weeks.
- If you are already taking medication or prescription drug, consult your doctor before using Lipo 6.
- If you have any pre-existing medical condition, be sure to speak with your doctor before using Lipo-6.
- Discontinue use of Lipo 6 two weeks before surgery.
- If you experience any severe reactions such as severe headaches, rapid heartbeat, shortness of breath, or dizziness, stop taking this product immediately.
- Lipo 6 contains ingredients that may be banned by some sports organizations.
- Individual results from Lipo 6 will vary.
- Keep out of reach of children.
Any Lipo 6 Lawsuits?
Nutrex was hit with a class-action lawsuit in 2010 when multiple of its products, including Lipo 6 Hers, Lipo 6 Black, and Lipo 6 Ignite, were found to contain amphetamines.
In January 2011, Lipo 6X was recalled from the Canadian market due to its potential to cause severe adverse side effects.
Although the recalls didn’t note any reports of adverse side effects, that changed when Nutrex Research, Inc. was sued for the adverse side effects two of their products, including Lipo 6 Hers Ultra Concentrated, caused per Casetext. The lawsuit also mentioned the products contains DMAA, a restricted ingredient.
Lipo 6 Price
As for the Lipo 6 cost, the MSRP listed on the official Nutrex website is $39.99 per bottle (120 liquid-caps).
This will last for 30 days. However, there is a sale price posted on the website, which is $23.95 per bottle (this may not be permanent).
There is a return policy mentioned on the Nutrex website as well. You essentially have 30 days to return Lipo 6 for a refund if you are unsatisfied, but this only applies to unopened/unused products.
If you opened the bottle of Lipo 6, you only have 15 days to return it from the time your order was received. Also, you must contact customer service before returning your order.
Where Can You Buy Lipo 6?
There are several stores and websites that sell Lipo 6 pills, which are as follows:
- Official Nutrex website
- The Vitamin Shoppe
Pros and Cons
Lipo 6 Pros and Cons
Lipo 6 Pros
- Some Lipo 6 ingredients are supported by research.
- Lipo 6 is readily available.
- Some positive Lipo-6 review.
Lipo 6 Cons
- Lipo 6 contains 200mg of caffeine per serving/400mg per day
Lipo 6 Alternatives
You can find various alternatives to Lipo 6 diet pills. There are numerous weight-loss supplements out there that help with fat burning and higher energy levels.
We suggest that you narrow your focus on products that contain safe ingredients.
As for Lipo 6, this formula uses both synephrine and caffeine (a substantial amount) to boost thermogenesis, but research has shown us that this ingredient combo can be dangerous.
While it is understandable to want weight loss results, you have to consider your safety first.
It is also beneficial to focus on user reviews to learn more about the product, and always find out if the diet supplement comes with a money-back satisfaction guarantee.
Nutrex Lipo 6 Black
Lipo 6 Black is an even more intense weight loss support formula available from Nutrex Research.
It aims to enhance metabolic rate, provide high energy and better focus, and better control your appetite to help balance food intake.
Here is a look at the ingredient label for Lipo 6 Black:
- Choline: 100 mg
- L-Tyrosine: 250 mg
- Caffeine Anhydrous: 220 mg
- Theobromine: 125 mg
- Grains of Paradise: 25 mg
- Black Pepper Fruit Extract: 5 mg
- Yohimbe HCl: 3 mg
- Rauwolscine: 1 mg
- Huperzine-A 1%: 100 mcg
As you can see, Lipo 6 Black contains even more caffeine and synephrine than the original formula. This is why it is labeled as “extreme potency” and has an even more extensive warning label on the bottle.
You are taking six capsules a day, instead of the four capsules you would take with plain Lipo 6.
As for the cost of Lipo 6 Black, it is listed as $39.95 per bottle (120 servings/20-day supply).
There are also plenty of Lipo 6 Black reviews posted on the main website so you can see what users have said about this product.
Nutrex Lipo 6 Black Ultra
Yes, there is also a Lipo 6 Black Ultra Concentrate, and you only need to take one capsule each morning and afternoon (30 minutes before meals).
It simply contains an Ultra Concentrated Fat Loss Support Complex of 294.5mg per serving/dose. These ingredients are as follows:
- Caffeine Anhydrous
- Yohimbine HCl
- Theobromine Anhydrous
- Advantra Z Citrus Aurantium (50% p-Synephrine)
Lipo 6 Black Ultra Concentrate provides extreme fat loss support, ramps up energy levels, and promotes serious weight loss.
It boasts super strong effects and the highest potency.
Lipo 6 Black Ultra Concentrate sells for $34.99 (60 servings/30-day supply), with a sale price of $20.99. Note that it cannot be used longer than 60 consecutive days.
On a side note, Nutrex Research also offers a product called Lipo 6 RX, and it contains clinically-tested TeaCrine, as well as other ingredients such as DMAE Bitartrate, Rauwolscine, N-Acetyl-L-Tyrosine, Caffeine Anhydrous, Ginger Root CO2 Extract, and DiCaffeine Malate.
This supplement aims to help with rapid weight loss results, as well as heightened energy and focus.
This product is advertised as a clinically-dosed maximum strength, rapid weight loss aid for both women and men. It is available for $39.95 per bottle (30-day supply).
“Didn’t feel any fat burning effect from taking it. I would take it every morning before my workout and work out for 2 hours. Didn’t feel any effect, not even the second time I would take it through the day. Only effect I felt was that my mood would easily make me irritated at small things that were annoying me. Not sure if this is only me, but I just wanted to share how this fat burner affected me.”
“I am using it for weight loss and I can already see a difference!”
“Doesn’t work so much for fat loss but has replaced my 4 cups of coffee a day. Gives you so much energy without the jitterness.”
The Bottom Line on Lipo-6
Is Lipo-6 the right one for weight-loss? Well, we like that we found some favorable customer comments and that it uses a few natural ingredients, but we’re a bit hesitant about this one because there’s no research supporting claims that you’ll lose weight. Also, we’re concerned about customer reviews talking about negative side effects and no results.
If you’d like to slim down, we suggest going with a program backed by research, that’s shown to work.
Among the best products we’ve seen this year is one called Noom. The multi-faceted approach to weight loss includes personalized meal plans, human coaching, an extensive food database and more. You get what science, and users, says works.
Also, the makers of Noom are so confident in their product that they’re offering a free trial offer.
Learn More About Noom »