Lipo 6 Review - Does This Fat-Loss Supplement Really Work? Are side effects and ineffective ingredients deal breakers?
It’s been a long journey but I feel I’m now qualified to advise you on whether or not to take Lipo-6. Our in-depth review examined the side effects, ingredients, scientific research and customer service quality. Additionally, we picked apart hundred of user comments and testimonials. Then, we summarized and refined to give you the info you need.
What is Lipo-6?
To start, Lipo-6 is a fat burner using fast-acting liquid capsules. The ingredients include caffeine 200mg, synephrine 20mg, guggulsterones 20mg, Bioperine 5mg and yohimbine 3mg. Supposedly it targets stored body fat and accelerates weight-loss. You’ll take two pills in the morning and another two mid-day. One benefit is that you can take it on-the-go. 
Lipo-6 was first released back in 2005 by Nutrex Research. This supplement can be purchased through the official website and trusted retailers. We like that the company has longevity in the market and we found some positive customer comments, but read on…
Lipo-6 Side Effects – “Positive or Negative?”
The first negative were the effects of Lipo-6 side effects. “This supplement contains multiple stimulants,” said our Research Editor. “While it could cause increased energy levels, there’s also the chance of adverse reactions.” 
One customer said, “I took the pills for two days and both days I experienced abdominal pain and feeling of fatigue.”
“Increase my heart rate and performance during workout but also caused me nausea when I workout,” said another. 
For some dieters, the side effects were not something they had to worry about. As one said, “Jitters on me never happened. Never felt a mood enhancer or euphoric, didn’t help with mental alertness or focus.”
Another suggested, “For beginners I suggest taking at least one pill a day just so your body gets use to it.”
Ineffective Ingredients – “Losing Weight?”
According to customer reviews about Lipo-6 ingredients, you may not see results. One customer said, “Took 2 pills an hour before lunch and dinner. No weight-loss or improved energy levels.” 
Another user stated, “I’ve been taking Lipo-6 for about two weeks. I just don’t feel anything.”
We also found a user that took a chance despite the advice of others. One reported, “People said it was ineffective, so i bought it anyways and it ended up working.”
According to a dieter, “Seems to be pretty solid. The only downfall is that you cannot have any other source of caffeine.”
After conducting years of research, it’s clear that if some certain part of a weight-loss supplement is concerning, like not producing results, the likelihood of long-term success is slim. There’s a bigger concern if dieters use Lipo-6 and don’t notice any changes.
The Science – “Verifiable Claims?”
The Nutrex Research website states Lipo-6 will cause dramatic fat loss in a short period of time. Sadly, we can’t find any published clinical evidence to support this claim. There are a few ingredients that have been tested, but any findings don’t relate to this formula. At DietSpotlight, we believe finding documented science is critical. Without it, we raise the red flag. 
The Bottom Line – Does Lipo-6 Work?
Is Lipo-6 the right one for weight-loss? Well, we like that we found some favorable customer comments and that it uses a few natural ingredients, but we’re a bit hesitant about this one because there’s no research supporting claims that you’ll lose weight. Also, we’re concerned about customer reviews talking about negative side effects and no results. 
If you’d like to slim down, we suggest going with a supplement that contains a formula backed by research, shown to work and not connected to harmful side effects.
Among the best products we’ve seen in 2016 is one called Leptigen. The four clinically-tested ingredients promote weight-loss and have been shown to help boost fat loss and accelerate metabolism. There’s no chatter about harmful side effects and user reviews indicate people are getting amazing results.
Also, the makers of Leptigen are so confident in their product that they’re offering a Special Trial Offer.
Previous Lipo 6 Review (Updated August 14, 2014):
What You Should Know about Lipo-6Lipo-6 is a diet supplement that's sold in the form of liquid capsules and manufactured by a company known as Nutrex Research. This product is marketed as the "complete fat-burning formula." One pitch for this diet supplement is the claim that it has the ability to burn fat pertaining to "all six fat receptors" (B2, B3, B1, Alpha-1, Alpha-2 and Alpha-3) the human body possesses. This in turn supposedly burns away excess body fat quicker. Basically Lipo-6 is claimed to promote a much greater fat loss than any other diet supplement currently gracing the vast market. In addition, Lipo 6 is infused with of bioperine, which is thought to have beneficial effects on the gastrointestinal and cardiovascular system, especially related to its ability to prevent diseases. Like many other diet products, Lipo-6 endeavors to boost the user's energy levels throughout the day, in addition to curbing hunger and random cravings. If it's curbing appetite, perhaps Phentalsim would be another choice when considering weight loss product, as it contains the primary ingredients known for reducing body fat. Lipo-6 is advertised as being a "satisfying" diet supplement. One that will not result in crashes or jitters toward nighttime. Lipo-6 supposedly targets individual areas of the body such as the thighs, buttocks, stomach and the love handle area. The recommended dosage of Lipo-6 is four liquid capsules per day (two taken 30 minutes prior to breakfast and two in the afternoon). Lipo-6 is a diet product recommended for both men and women that wish to lose excess body fat. A one-month supply (120 liqui-caps) of Lipo-6 can be purchased online for as low as $24.99.
List of Lipo 6 IngredientsPrimary ingredients found in Lipo-6 are Synephrine HCL (20 mg per serving), Guggulsterones E and Z (20 mg per serving), Yohimbine HCL (3 mg per serving), Bioperine (5 mg per serving) and caffeine (200 mg per serving). Other ingredients found in Lipo-6 are Oleic Acid, Gelatin and Sesame Oil.
Product FeaturesLipo-6 is a diet product that comes in liquid capsule form and is to be taken with water two times (4 capsules) daily. This dietary supplement is geared toward men and women and endeavors to dramatically reduce body fat from the love handle area, thighs and buttocks. Lipo-6 offers active components like Synephrine HCL (20 mg per serving), Guggulsterones E and Z (20 mg per serving), Yohimbine HCL (3 mg per serving), Bioperine (5 mg per serving) and caffeine (200 mg per serving). These primary ingredients are claimed to reduce hunger, burn fat and increase the dieter's energy levels and metabolism, but without negative side effects. An alternative to Lipo 6, Performix SST, is a super thermogenic supplement loaded with caffeine. It's intended use is said to promote healthy weight loss by burning fat and boosting metabolism, but recommended for morning use.
Advantages of Lipo 6
- Lipo-6 can be conveniently ordered via the Internet without a doctor's prescription.
- Lipo-6 comes in an easy-to-take liquid capsule form.
- Lipo-6 is Ephedra-free.
Disadvantages of Lipo 6
- There does not appear to be an informative official website for Lipo-6, but rather just a website with a massive ad for the product.
- Lipo-6 does not appear to have any substantial clinical research offered online by the manufacturer.
- There are no guarantees that Lipo-6 will benefit you.
- Lipo-6 contains substantial levels of caffeine, which is known for pulling water off of the body and muscles.
- Four Lipo-6 liquid capsules have to be taken each day, which may prove tedious for some users.
- Lipo-6 does not come with a money-back guarantee.
ConclusionWith such an abundance of diet supplements and products on the market, some dieters may find that Lipo-6 appears fairly ordinary. With little information offered regarding the Lipo-6 product on the official website, it may be tough to completely trust where Lipo-6 came from, what process was involved with developing it and why it does not come with a money-back guarantee. In the long run, we found that there are many other diet treatments and products on the market with a better pitch. And when it comes down to companies that are reliable, Slimquick can be taken into consideration as the recommended dosage, three capsules, promotes weight loss using all-natural ingredients.
Lipo 6 Questions & Answers:
We trimmed down hundreds of user comments about Lipo-6 into this helpful FAQ.
What are the side effects of Lipo-6?
Some Lipo-6 side effects, based on customer comments, include increased heart rate, dizziness, headaches, anxiety and nausea.
What is in Lipo-6?
What is the active ingredient in Lipo-6?
The active ingredient in Lipo-6 is a blend of bioperine, caffeine anhydrous, yohimbine HCL, guggulsterones and synephrine HCL.
Does Lipo-6 Work?
There’s no scientific research linking Lipo-6 ingredients to weight-loss. There are studies supporting caffeine, but not specific to this formula.
How much does one bottle of Lipo-6 cost?
One bottle of Lipo-6 costs $44.95. If you order two bottles you pay $84.95, which is a $4 discount.
How do you take Lipo-6?
You will need to take two Lipo-6 capsules in the morning and one in the evening. The company suggests not taking more than six per day and not within six hours of sleep.
Can I take Lipo-6 if I have a health condition?
If you are pregnant, nursing, taking prescription medications, combating health conditions or under 18 years of age you should consult with a physician prior to starting a weight-loss supplement, including Lipo-6.
What do users like about Lipo-6?
Some dieters like that Lipo-6 is readily available, the low price and the fact that the bottle is portable.
What do users NOT like about Lipo-6?
Some customers didn’t like the side effects caused by Lipo-6. There are also reports of no weight-loss and difficulty reaching the customer service department.
Who makes Lipo-6?
Nutrex Research is the makers of Lipo-6.
How do I contact the Lipo-6 customer service department?
You can reach the Lipo-6 customer service department by calling 1-888-368-8739 or sending correspondence to the corporate headquarters at Nutrex Research, Inc. 579 S. Econ Circle Oviedo, FL 32765. You can also contact an agent by using the customer feedback form on the official website.
Can I contact Lipo-6 through social media?
How much caffeine is in Lipo-6?
Each serving (two capsules) of Lipo-6 contains 200mg of caffeine.
Is Lipo-6 just for men?
No, Lipo-6 can be used by men and women. The product doesn’t contain gender-specific ingredients.
Do you need to exercise when taking Lipo-6?
The company recommends including fitness to maximize results, but no specific program is provided.
Is there a guarantee on Lipo-6?
There’s no guarantee for Lipo-6 mentioned on the official website.
Do you know of any special deals or discounts on Lipo-6?
You will receive a $4 discount on Lipo-6 when you order two bottles. However, our readers are excited about taking advantage of Leptigen’s Special Trial Offer. Click above to learn more.
Lipo 6 User Tips:
7 Top User Tips
Over the years, we’ve realized that Lipo 6 users have insights to share. After consulting thousands of reviews and comments we collected the following tips to help you learn more about this product.
“When you take it in the early evening, be prepared to wake up in the middle of the night or not sleep at all.” Alex
“Hydration is key with these or you will get killer headaches.” Jason
“It says don’t take it for more than two months so I cycle two months on and two off.” Sam
“I use this product with a lower calorie diet and lifting 5-6 days a week. It helps but it doesn’t do the work for you.” Nora
“Do not take this product five to six hours before bed because it will ramp up your energy and you will not be able to sleep!!” Veronica
“When I first started taking it my head would throb all day long. I found that if I drank it with a full bottle of water and then drank water all day the headaches went away.” Jay
“It made me feel nauseous at first but as long as I eat something with it that doesn’t seem to happen.” Brad
Lipo 6 Scientific Abstracts:
Performance during the 45 min energy based target time trial were significantly faster (∼5.0%) for the caffeine group and the coffee group in comparison to the decaf and placebo (38.35±1.53, 38.27±1.80, 40.23±1.98, 40.31±1.22 minutes p<0.05). These substantially faster times were mirrored in both the caffeine as well as the coffee groups. The average power for the caffeine and coffee groups throughout the time trials were substantially better in comparison to the decaf and the placebo groups (294±21 W, 291±22 W, 277±14 W, 276±23, p<0.05). There were no important alterations noticed between the placebo and the decaf groups during the time trials. In conclusion, both caffeine and coffee (5 mg/kg/BW, 5 mg/kg/BW, respectively) ingested 1 hour before exercise could enhance endurance exercise performance. 
Bitter orange (p-synephrine), in general, by itself or mixed in a combination with additional herbal ingredients, did not create substantial adverse effects as an elevation of blood pressure or heart rate, nor did it alter electrocardiographic data, blood cell counts, serum chemistry, or urinalysis. Bitter orange by itself or mixed with other products proved to elevate resting metabolic rate as well as energy expenditure, and mild elevations in weight-loss were noticed within the p-Synephrine products when administered for 6 to 12 weeks. In conclusion, there needs to be longer studies in order to further examine the efficacy of these ingredients and to assess their safety within these conditions. 
Recent studies have shown that guggulsterone upregulates the BSEP (bile salt export pump, which is an efflux transporter that eliminates cholesterol metabolites as well as bile acids from the liver. Guggulsterone upregulation of bile salt export pump expression favors cholesterol metabolism within bile acids, in turn representing an additional mechanism for its hypolipidemic traits. Guggulsterone has been studied and documented to strongly inhibit nuclear factor-κB activation. Nuclear factor-κB is an important regulator of inflammatory responses. The mechanism of the anti-inflammatory activities of guggulsterone is due to the repression of NF-κB activation. 
Both subjective as well as objective criteria were taken into account regarding the efficacy evaluation of Yohimbine. The subjective principles included improved sexual desires, frequency of sexual contacts, sexual satisfaction, and erection quality during intercourse. The objective principles of outcome were based on penile rigidity improvement which was studied via polysomnography within the sleep laboratory. In conclusion, Yohimbine’s response rate was noted being substantially more effective than the placebo (71 versus 45%). It was found that Yohimbine was very well tolerated with only 7% of subjects rating their tolerability at fair or poor. Most of the negative effects reported were mild and there were no significant adverse effects reported. 
- 1. The Metabolic and Performance Effects of Caffeine Compared to Coffee during Endurance Exercise (2013). PLoS One. November 19, 2016.
- 2. A Review of the Human Clinical Studies Involving Citrus aurantium(Bitter Orange) Extract and its Primary Protoalkaloid p-Synephrine (2012). International Journal of Medical Sciences. November 19, 2016.
- 3. Therapeutic Effects of Guggul and Its Constituent Guggulsterone: Cardiovascular Benefits (2007). Cadiovascular Therapeutics. November 19, 2016.
- 4. Double-blind, placebo-controlled safety and efficacy trial with yohimbine hydrochloride in the treatment of nonorganic erectile dysfunction (1997). ) International Journal of Impotence Research. November 19, 2016.
Lipo 6 Side Effects:
Lipo-6 is a weight-loss supplement that is used to increase weight-loss and to breakdown stored fat. Though side effects don’t always happen, we found user comments to prove to you that they still happen.
“Lipo 6 gave me so much energy my head felt like exploding. My heart rate went up and my heartbeat became much harder. I even had heartburn. Pain throughout my chest and shortness of breath.” Wouter
“I felt a little discomfort in my stomach like a nausea towards the end of my work out.” Maria
“I am feeling tiredness and increase in my heart beats and mild headache” Aiden
“I am also having head aches and bloating in [my] belly.” Abby
“I feel very ill, [I’m] having too much shivering and [I have a] headache and my heart is beating too fast like never before” Quincy
“Lipo-6 gave me an upset stomach and jitters.” Bob
“I took this product for three weeks and actually gained weight while taking it and dieting.” Gerald
“I felt sick and threw up like half to an hour later.” Caroline
“I felt lightheaded.” Shelae
“I stopped it because [it] gave me headaches!” Sydney
Whenever you take a nutrition or weight-loss product of any kind, the potential negative consequences must be looked at. In the case of Lipo 6 side effects, there have been a number reported, though they are few and far between.
Pain in the abdomen can be general, occurring across the abdomen, or on either side. Pain can also be localized to a specific spot in the stomach region. The abdomen is the area between the chest and pelvic areas. Pain can be sharp or dull, constant or intermittent.
What causes abdominal pain?
The potential origins of abdominal pain are too many to list but include severe sources such as bowel obstruction, ulcers and kidney stones. More common and less severe causes include the flu, constipation, gas, menstrual cramps, and adverse reactions to foods, medications and nutritional supplements. 
Rapid Heart Rate
Often referred to as arrhythmia, a rapid heart rate can present as a fluttering or racing heartbeat and is accompanied by shortness of breath, sweating, and chest pain.  A rapid heart rate can be associated with a condition requiring medical attention.
What causes rapid heart rate?
In rare cases, causes include high blood pressure, diabetes, blocked arteries or thyroid problems. Other contributors are consumption of alcohol, spicy foods, smoking, stress, medicines and nutritional supplements of various kinds.
Anxiousness is an uneasy feeling of being unsettled and can include symptoms throughout the body, such as muscle tension, stomach pain or nausea, headaches, rapid heart rate, high blood pressure and sweating. This nervousness can come on quickly or be an ongoing condition.
What causes anxiousness?
Most nervousness is the result of tough times in one’s life, such as a death, job loss, moving, financial struggles, or problems in a relationship. Medicines and nutritional supplements are also causes of anxiousness, for some people.
The body is full of water inside cells, blood vessels and tissues and cannot survive without a continual intake of water. When more water is leaving than entering, the resulting condition is dehydration. We lose water throughout the day through sweat, urine and defecation. The body regulates its water level and moves water throughout in order to protect the most vital areas first. Dehydration is easily cured when liquids, especially water, are consumed.
What causes dehydration?
Dehydration will result from a lack of drinking water and other liquids. It is also common for people to become dehydrated from taking medicines and supplements. While anyone can become dehydrated, people with chronic illnesses are most at risk.
When exploring products to assist with weight-loss, one must be aware of impending side-effects that may surface. Prospective users of Lipo 6 rarely have issue, but reports are there. To cut down your risk of problems, you may want to speak with your physician before taking this fat burner. You may alos want to consider one that’s caught our attention. Leptigen isn’t cconnected to adverse reactions and users are talking about seeing great results. Want to learn more about it? Click above.
Lipo 6 claims to help you "Burn Fat Fast." It is produced by Nutrex Research, Inc. The official website offers a wealth of information, including a product label. Like so many other diet pills, this one is based on caffeine.
Lipo 6 Ingredients and Supplement Facts
Serving Per Container: 60
|Amount per Serving||% DV|
Other Ingredients: Glycerin, vegetable cellulose, purified water, polysorbate 90
We examined the Lipo-6 ingredients in order to give you the bottom line on this weight-loss product.
Caffeine is a stimulant . It is often found in coffee, tea, and soda. It has also become a popular ingredient in many weight-loss supplements.
What Is It Supposed To Do?
Caffeine is commonly consumed to increase mental alertness. However, when found in supplements, it has been used to treat various ailments, including migraines, throat cancer, muscle pain, low stamina, eye spasms, obesity, fatty liver disease, erectile dysfunction, and more.
According to Medicine and Science in Sports Exercise, “The additional 22% reduction in body weight, 25% reduction in epididymal fat-cell size, and 5 and 6% reductions in epididymal and retroperitoneal fat-pad weights, respectively, in the caf-ex group beyond the no caf-ex group support the hypothesis that fat loss with aerobic exercise can be increased when caffeine is ingested prior to the training sessions.”
Also known as bitter orange, synephrine has become a popular ingredient in many supplements since ephedrine was banned by the FDA. It is considered a stimulant and is used heavily in the dieting sector.
What Is It Supposed To Do?
Synephrine  is used to help treat fungal infections, poor appetite, obesity, low blood sugar levels, gastrointestinal disorders, inflammation, pain, fatigue, and nasal congestion.
In a study published in Experimental Biology and Medicine, researchers tested the effects of synephrine in weight-loss supplements. They concluded that, “There is little evidence that products containing C. aurantium are an effective aid to weight loss.”
Guggulsterones, also known simply as guggul, are derived from the Commiphora mukul tree found in India.
What Is It Supposed To Do?
Guggulsterones has been consumed historically to treat arthritis, high cholesterol, obesity, acne and skin diseases.
According to a study published in Journal of Dietary Supplements, “Guggulsterones at the dose of 400 mg/kg body weight was able to significantly reduce food intake and limit body weight gain over a period of 15 days.” However, these effects were seen in rats, and if a person about 28 grams, or about 700 of an average pill.
One that’s caught our attention is one called Leptigen. To learn more about the clinically-tested ingredients, click above.