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Plexus Triplex Review - 11 Things You Need to Know

Plexus Triplex is a “system for a healthy gut and weight loss” that includes three supplements, Plexus Slim, Bio Cleanse, and Pro Bio 5. Apparently, the use of these three supplements helps improve health by detoxing the body, supporting the digestive tract, and aiding in weight loss. However, the use of that many supplements with unscientifically proven ingredients, like chlorogenic acid and orange peel, is cause for concern.

We looked into each product’s claims and the claims of the Triplex to see what consumers would expect from using the products. In the end, we compared the claims from Plexus to the available research on the supplements and their ingredients to give you the bottom line.

Plexus Triplex can be purchased through their Official Site.

Plexus Triplex Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Plexus Triplex?

Plexus TriPlex, as claimed by its manufacturer, is a comprehensive three-product system specifically formulated to enhance gut health. The goal is threefold: to “weed” out undesired microbes, “seed” the gut with advantageous probiotics, and “feed” these probiotics with nourishing prebiotics. In this review, we’ll explore its components, their claimed benefits, potential side effects, and any controversies associated with the product.

According to the producer, Plexus TriPlex is more than just a weight loss supplement kit. The trio is geared towards utilizing the “3 R’s” strategy: Restore, Remove, and Rebalance the body’s internal equilibrium. The kit encompasses Plexus Slim, Bio Cleanse, and ProBio 5.

The manufacturer asserts that this combination pack, featuring Plexus Slim, Plexus ProBio 5, and Plexus BioCleanse, aims to boost overall health and foster weight loss. Its intent is to prompt the body to resist undue weight gain, thereby amplifying weight loss potential. These products also have some other benefits that are different from the usual, but let’s tackle the elephant in the room before we go on. Does the formula have a chance at being effective?

  • Meta Ions in Life Sciences – “There is evidence for the efficacy of chromium supplements in improving conditions in metabolic syndrome and in some [T2DM] patients, but there are no effects on body composition in healthy individuals.”
  • International Journal of Obesity Supplements – There is some indication that garcinia may help with weight loss, via a few pathways. Still, in some cases, the research is more than 20 years old or completed on lab rats.
  • Obesity Reviews – ALA, or alpha-lipoic acid, is also a promising ingredient, based on a research review, though the exact amount needed to see results is up for debate.

Plexus and the BBB

Plexus has held BBB accreditation since December 29th, 2019, boasting an “A+” rating. With an average score of 3.58 out of 5 from 86 customer reviews, they’ve resolved 51 complaints in the past three years, including 25 in the last 12 months.


1. Questionable Business Practices: Plexus has faced criticisms regarding its recruitment and sales tactics, leading to some ambassadors leaving the MLM.
2. Misleading Claims: In 2020, Plexus received a warning from the FTC due to representatives making unfounded health claims during the pandemic.
3. FDA Warning: In 2014, the FDA warned Plexus for marketing some of its products as drugs based on claims they could treat specific health conditions.

Customer Service Information

Plexus offers a Live Chat option and an email form for all your needs.

Address: Plexus Worldwide® 9145 East Pima Center Parkway Scottsdale, Arizona 85258 U.S.A. Cross Streets – 90th Street and the Loop 101

Phone: 480-998-3490 (EN), 480-374-4998 (ES)

Customer Service Assistance Email Forms: https://helpcenter.plexusworldwide.com/hc/en-us/requests/new

Plexus offers a 60-day money-back guarantee on all purchases.

Plexus Triplex Competitors

Animal Stak
3-Day Refresh
Omnitrition Diet

How Did Plexus Triplex Start?

The Plexus Triplex was introduced in 2011 by Plexus Worldwide. Plexus Worldwide is a multi-level marketing company based in Arizona that decided to launch Plexus Triplex as a weight management system.

They claim that their products make you feel better, look better, eat better, focus better, and live better. They also claim that they have concentrated on creating healthcare products that help users lose weight and remove toxic chemicals from their bodies. Their products are 100% vegetarian, gluten-free, and non-GMO.


Plexus Triplex Claims

Plexus Worldwide introduced Plexus Triplex in 2011. This company feels that its products are life-changing. They also claim that their gut-balancing weight-loss combo, Plexus Triplex, does the following:

  • The formula used in developing Plexus Triplex is one of the best for weight loss and management of high blood sugar levels; therefore, it helps you achieve a healthy lifestyle.
  • Plexus ProBio 5 helps replenish internal flora to its proper state of balance in your body.
  • ProBio 5 also maintains the balance of intestinal yeast.
  • ProBio 5 improves the natural response to imbalance.
  • ProBio 5 supports a healthy intestinal tract.
  • Plexus Triplex enables you to lose weight suitably. It mainly attacks the fat stored around the stomach, thighs, and buttocks.
  • These fats sometimes possess toxic substances that irritate your immune system.
  •  Fortunately, Plexus Triplex helps you get rid of them very quickly.
  • The Plexus Triplex Combo will make you healthy from the inside out, thus, giving you the perfect body shape and maintaining it.
  • Plexus BioCleanse cleanses the gastrointestinal tract.
  • Reduces discomfort, gas, and bloating.
  • Removes harmful microbes and substances.
  • Enhances your body’s detoxification process.
  • Plexus Slim helps with weight loss.
  • It promotes the growth of beneficial gut microbes.
  • It enhances metabolism.
  • It increases quantities of Bifidobacterium and Lactobacillus.

Plexus Triplex Ingredients

Plexus Triplex consists of various ingredients which contribute to overall health management and weight loss. Most of its components are natural. They are:

  • Bioflavonoid complex
  • Xylooligosaccharide
  • Protease
  • Chitosanase
  • Cellulase
  • Serrapeptase
  • Green coffee bean extract
  • Chromium
  • Alpha lactic acid
  • Stevia
  • Garcinia cambogia
  • Lactobacillus
  • Magnesium

Details on Plexus Triplex Ingredients

Plexus Triplex contains some beneficial ingredients which they claim are “helpful towards gut control, weight-loss, and help in maintaining blood-sugar.” All the elements present in Plexus Slim, Plexus ProBio 5, and Plexus BioCleanse combine and work together to give excellent results. These three products (when taken together daily) increase the effectiveness and speed up the overall health development process of the individual. Here is how Plexus Triplex works:

Chromium Polynicotinate

According to the journal Diabetes, Obesity & Metabolism, “niacin-based chromium (chromium polynicotinate) given to modestly dieting-exercising African American women caused a significant loss of fat and soaring of muscle.” However, 2020 research shared in Clinical Nutrition Research showed that 400mcg of chromium taken daily had no impact on weight or body mass index.

Garcinia Cambogia

Although the ideal dosage has yet to be determined, the journal Nutrition Hospitalaria concluded: “studies suggest positive results about the effectiveness of the GC on the weight loss process.”

Alpha Lipoic Acid

According to the journal Clinical Nutrition, “supplementation with ALA slightly but significantly decreased body weight and BMI.” But, just how much do you need? Well, based on older research from 2011, you could need as much as 1800mg of ALA to see any results, according to The American Journal of Medicine.

Green Coffee Bean

Research presented in the Asian Pacific Journal of Tropical Medicine concluded: “GCBE (green coffee bean extract) has a potential anti-obesity effect with lowering body fat accumulation.”

Xylooligosaccharide (XOS)

The Gastroenterology Research and Practice journal concluded: “the intestinal bacterial phase was improved after the daily consumption of 150 g of rice porridge containing XOS for 6 weeks [and] the beneficial effects of XOS on intestinal functions and health.”


Benefits of Plexus Triplex

All three products in Plexus Triplex, when taken together, contribute to the overall development of health. The Triplex combo consists of three products that you take multiple times daily.

The Triplex combo contains ingredients proven to be beneficial for fast weight loss, reducing bloating, and removing toxic substances from the body. It also claims to promote colon health.

There are multiple benefits of using the Plexus Triplex combo.

First, we’ll put forward the benefits of using Biocleanse, then Plexus Slim, and Plexus ProBio 5. The benefits of all three products are listed below:

Plexus BioCleanse Benefits

  • It helps to cleanse the gastrointestinal tract.
  • It helps reduce discomfort, gas, and bloating.
  • Eliminates harmful microbes and substances.
  • Enhances the detoxification process.
  • Gluten-free
  • 100% Vegetarian

Plexus Slim Benefits

  • Contributes toward helping with weight-loss.
  • Promotes the growth of beneficial gut microbes, which supports digestive health.
  • It focuses on enhancing metabolism.
  • It provides an increase in Bifidobacterium and Lactobacillus. Bifidobacterium is part of the colon flora in mammals and acts as a probiotic.
  • 100% Vegetarian
  • Gluten-free
  • Non-GMO
  • Only 20 calories

Plexus Probio 5 Benefits

  • Works to maintain the balance of intestinal yeast.
  • Contributes mainly toward improving the natural response to imbalance.
  • Promotes and supports a healthy intestinal tract.
  • Gluten-free
  • Delivers 2 million CFU per capsule

How to Use Plexus Triplex

To properly use Plexus Triplex, follow these steps:

Bio Cleanse

Two capsules of Plexus BioCleanse should be taken with 8oz of water twice daily. It should be taken either between meals or at night. 2 capsules between breakfast and lunch and two between lunch and dinner.

ProBio 5

It is best to take 1-2 capsules of Plexus ProBio 5 at bedtime. Always take on an empty stomach. You can take up to four capsules.


The packet requires 12-20 ounces of water. Pour the package of Plexus Slim into a glass of water and shake it well. It should be taken 30-60 minutes before any meal, twice a day. It is best to take Plexus Slim early in the morning. It proves more effective this way.

Side Effects

Side Effects of Using Plexus Triplex

There are fewer chances of experiencing side effects from using Plexus Triplex since it comes from many natural ingredients. However, some may have reactions, which include:

  • Nausea
  • Upset stomach
  • Headaches
  • Irregular bowel movements

If any side effects occur, you should immediately consult your doctor or a healthcare professional to avoid any side effects, resulting in severe health problems and emergencies.


Plexus Triplex Cost

The Plexus Triplex system will cost differently depending on which package you choose.

Currently, the full Plexus Triplex system is exclusively available on its official website. However, individual products can be purchased from other online retailers, including Amazon, Walmart, CVS, and Sears. Two packages are offered: the Triplex Hunger Control Combo and the TriPlex Microbiome Activating Combo, both containing identical supplements. Each package is priced at $158 for a single purchase or $112 for VIP customers. Should you opt for a subscription, the monthly cost is $158 for the initial three months, after which a 10% discount is applied, reducing the price to $142.20.

What Users Are Saying

What Users Are Saying

“Been using for years with success.”

“This is one my favorite pre-biotic supplements. Recommended directly by my gastroenterologist. I always take 1-2 per night before going to sleep. Has really helped my stomach (and already on my second bottle). Do plan to purchase again!”

“July 20, 2023. Started taking the bio cleanser 2 weeks ago and it was good for my constipation, bu now having pain in my ankel and arch bones, not muscles. I don’t know if it’s a side effects. I had to wrap my ankle with elastic sports tape. I can’t walk, very painful. This item is very expensive $53, and can’t return it. This pain is not the result of walking, jugging, running, or … This morning, I was going to the kitchen and just happened. Very Painful. Took a Tylenol and see what’s happening next.”

Bottom Line

The Bottom Line on Plexus Triplex

Plexus Triplex is a system addressing weight management with Plexus Slim. Then Plexus BioCleanse and Probio5 are designed to help promote a healthy digestive system. However, there are always alternatives when you consider a solid weight management plan.

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One of the products we like the most is Noom. The program is clinically proven to help you lose weight and maintain that weight loss thanks to years of research and development. This definitely isn’t your average smartphone app.

The company behind Noom is so certain you’ll see results that they’re offering a free trial offer to Dietspotlight readers.

Learn More About Noom »
Plexus Triplex Review
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Plexus Triplex

What is Plexus Triplex?

Plexus Triplex is a kit of three supplements, Plexus Slim, Bio Cleanse, and Pro Bio 5, designed for healthy gut and weight loss.

What are the side effects of Triplex Plexus?

Triplex Plexus, also referred as Plexus Triplex, possible side effects may include stomachache, jitters, abdominal discomfort, diarrhea, headache and nausea, going on some customer reviews.

What are the ingredients in Plexus Triplex?

Plexus Triplex ingredients are (Plexus Slim) chromium, chlorogenic acid (from green coffee caffea arabica bean) extract (contains less than 2% natural caffeine), garcinia cambogia fruit extract, alpha lipoic acid, polydextrose, citric acid, natural flavors, beet (beta vulgaris root) extract (for color), and stevia (stevia rebaudiana leaf) extract. (Plexus Bio Cleanse) magnesium, vitamin c, sodium and bioflavanoid complex. (ProBio 5) vitamin B6, vitamin C, protease, chitosanase, cellulase, serrrapeptase, bacillus coagulans, lactobacillus acidophilus, bifodobacterium longum, lactobacillus plantarum, sacchartomyces boulardii, grape seed extract, gelatin, water and brown rice powder.

Does Plexus Triplex work?

There isn’t any solid research to support Plexus Triplex and its claims regarding weight-loss and improved health. However, these supplements do provide some vitamins and probiotics to benefit the immune system and digestive tract. Also, the Chlorogenic Acid in the Plexus Slim supplement should help balance blood sugar levels to some degree.

How much does the Plexus Triplex combo cost?

Plexus Triplex costs $158 for a one time purchase and if you choose subscription, the monthly cost is $158 for the initial three months, after which a 10% discount is applied, reducing the price to $142.20.

Where can I buy Plexus Triplex?

Plexus Triplex can be purchased using their Official Site.

How should I take Plexus Triplex?

To use Plexus Triplex, you need to take all three supplements daily. Take one ProBio capsule at dinner or bedtime.

Take two capsules of Plexus Bio Cleanse twice a day between meals with eight ounces of water.

Add Plexus Slim to a glass of water and drink it once daily.

The Bio Cleanse supplement will last for 15 days, while Plexus Slim will last for 30 days and ProBio 5 can last up to 60 days.

Is Plexus Triplex for both men and women?

Yes, Triplex Plexus is for both men and women.

Does Plexus Triplex help with constipation?

The company states that Plexus Triplex helps relieve constipation.

Will you have to use the restroom more frequently while taking Plexus Triplex?

Yes, it is common to use the restroom more frequently while using Plexus Triplex.

Do I have to take Plexus Triplex forever?

You do not have to take Plexus forever. The aim of any supplement is to support overall health and wellness, while you learn how to live well without it. This is especially true for weight-loss products. They are a temporary solution.

Have other people had adverse reactions after using Plexus Triplex with slim hunger control drink I'm experiencing lightheadedness weakness diarrhea and mild headache?

Since Plexus Slim contains caffeine some of the side effects can include headaches, dizziness, anxiety, and insomnia if too much is taken. The Probio5 and BioCleanse both work to improve gut health and function. This is where many stomach issues are rooted, most likely.

What are side effects of taking Plexus Triplex and not drinking enough water?

The side effects of Plexus Triplex include nausea, upset stomach, headaches, and irregular bowel movements. Because the supplements work on gut health, in addition to weight loss, not getting enough water could cause constipation.

How much weight can you lose using Plexus triplex?

It is difficult to say how much weight one can lose using Plexus triplex, as individual results may vary. However, users have reported that it can help to speed up metabolism and promote weight loss.

How do I contact Plexus customer service?

You can contact Plexus customer service through live chat on their website or email form. You can also call their phone number at 480-998-3490 (EN), 480-374-4998 (ES).

What is the Plexus Triplex guarantee?

Plexus offers a 60-day money-back guarantee on all purchases.

When was Plexus Triplex introduced?

Plexus Triplex was introduced in 2011 by Plexus Worldwide, a multi-level marketing company based in Arizona.

What claims does Plexus Triplex make?

Plexus Triplex claims to help detox the body, support the digestive tract, and aid in weight loss. It also claims to replenish internal flora, maintain the balance of intestinal yeast, improve the natural response to imbalance, and support a healthy intestinal tract.

Are the ingredients in Plexus Triplex natural?

Most of the ingredients in Plexus Triplex are natural.

What are the benefits of Plexus Triplex?

The benefits of using Plexus Triplex include fast weight loss, reducing bloating, removing toxic substances from the body, and promoting colon health.

What are the competitors of Plexus Triplex?

The competitors of Plexus Triplex include Animal Stak, Align, 3-Day Refresh, and Omnitrition Diet.

Is there any scientific evidence to support the claims of Plexus Triplex?

There is limited scientific evidence to support the claims of Plexus Triplex, and some of its ingredients have not been proven effective for weight loss or gut health.

Are there any concerns about using Plexus Triplex?

The use of multiple supplements with unproven ingredients, like chlorogenic acid and orange peel, is cause for concern. Additionally, some individuals may experience side effects from the ingredients in the supplements.

Can I take Plexus Triplex if I have a medical condition?

Before starting any supplement, including Plexus Triplex, it’s essential to consult with a healthcare professional, especially if you have a medical condition. They can provide guidance tailored to your specific situation.

How long does it typically take to see results with Plexus Triplex?

The time it takes to see results can vary for each individual. Some users have reported noticing changes within a few weeks, while others may take longer. It’s crucial to maintain a balanced diet and regular exercise for optimal results.

Can Plexus Triplex be combined with other Plexus products?

Plexus suggests that its products can be used in combination, but it’s always recommended to consult with a healthcare professional before mixing multiple supplements to ensure there are no contraindications or potential side effects.

Are there any allergens in Plexus Triplex?

While Plexus strives to maintain high-quality standards, it’s essential to read the product labels or consult the official website for detailed ingredient information to ensure the product doesn’t contain any allergens specific to your needs.

Do I need to adjust my diet or exercise routine when taking Plexus Triplex?

While Plexus Triplex aims to support gut health and weight loss, it’s always beneficial to maintain a healthy diet and regular exercise routine for best results. The supplement alone is not a replacement for a balanced lifestyle.

28 Plexus Triplex Reviews

  • Rita

    Why am I feeling tired on plexus triplex. Been on this for 10 days now ?

  • Judy (Verified Purchase)

    I have been on Triplex and ACTIVE since May 2020. Best thing I ever did. I have not lost weight, but I have definitely lost inches, and I definitely have more frequent and regular bowel movements. I have more energy also. Just feel better overall. I will agree with others, that it is expensive, but I believe I am worth it.

  • 100% Beyond Satisfied
    Robyn Stone (Verified Purchase)

    Amazing results with my autoimmune issues. Hair is growing very fast and complexion is beautiful!

  • The side effects weren't worth it!
    Heather Braker (Verified Purchase)

    I tried Plexus Triplex for 3 months and it nearly did me in (not exaggerating either). Because of the growing side effects I was having, my consultant spoke with someone at the company and they suggested I just do a 1/2 dose – I was never able to take a full dose. Aside from the daily diarrhea, headaches, and nausea, I was having side effects that they don’t even list because they’re so rare, like sore joints, skin rash, and hair loss. I stopped taking it but then it was like my immune system just stopped working. My doctor said it was a sever allergic reaction to a combo of stuff in the triplex. It took me months to recover. Guess I’m in the minority, but I can’t be the only one with sever side effects to their products.

  • IBS-D

    I was thinking about trying this product. However I have IBS-D, and am noticing lots of comments that it causes more frequent bathroom visits, it will help with constipation, and one of the possible side effects is diarrhea. I certainly don’t need any of that. Do you have thoughts you would share? Do you think I should use this product with my condition? I have been using another system for about 2 years & it has helped with the IBS-D. Not sure if it would be wise for me to start something new.

    • Luis (Editor)

      Hi Connie! We suggest checking with your doctor to see if this product is safe to take with your condition.

    • Anonymous

      I have been taking it for a month. The first 7 to 10 days I had diarrhea, but that seems to have gone away. I do have more frequent bowel movements, but they are definitely not diarrhea.

  • Too pushy
    Kathy Mitchell (Verified Purchase)

    Ive been on pkexus for 3 months now and i feel like i have more energy…something is happening but I dont feel comfortable with pushing it on people! The way i see it, if it shows on me the results, im drinking lots of water too & exercising so i do feel good but the price is high & i didnt know about the exchange rate! I was discouraged to use prepaid cards because i dont trust online banking-My personal choice ?but it does work ( the prepaid cards)

    • jackie Haskell

      i agree with you-I don’t want to sell-I have more energy but I look 7 mo. pregnant-they want me to stay on been on 2 mo.

  • Barbra

    Are the ingredients organic, non GMO, etc.

    • Devon (Editor)

      Plexus claims all products are natural.

  • Catherine

    I have been taking Triplex for a full week. I do like that I sleep like a rock. I think that alone helps me feel more energized during the day. It does help with my cravings. Am I supposed to alter my diet? It would be helpful if there was a list of foods that would help with this issue.

    • Adrian (Editor)

      Hi Catherine! There’s not a specific Plexus Diet, but the company encourages healthy eating. Another weight loss solution you may want to check out is one called Dietspotlight Burn.

  • Hoping to see results soon !
    Jen (Verified Purchase)

    I have been on the Plexus Triplex for about 4 weeks now, not noticing any benefits yet, but my ambassador tells me some people take longer to feel the results. I do enjoy the taste of the Slim, not sure why people are saying it tastes nasty?? My ambassador has said it’s worked well for her, she has more energy, sleeps better and has the desire to work out now. Hoping I will have the same results soon, but at the cost of $182 CAD a month, not sure it’s worth it. Will try it for a little bit longer and see.

  • Christine lee

    Don’t order. They just want your money. You can ring within the trial period to cancel further shipments. But you will still have to pay to post the unused sample (even its empty bottles) at your expense to the uk. And the product does not work anyway.

    • Pam

      You must have your info mixed up with some other product. Plexus Worldwide products are not available in the UK. You can cancel within 60 days and get your money back, and you don’t have to send any products back to the company. And the products do work if you follow the schedule and give them time to work. It takes time to get your gut healthy. 🙂

  • Jima

    I have been taking Plexus Triplex since December 2015. I feel great, rest great, and my cravings or desire to eat foods that sabotage my health and weight loss goals. To date I’ve dropped 40lbs, 3 clothes sizes, and the daily bloated feeling I once had. Can you say HAPPY? I even dropped almost 2 points on my recent A1C Blood Test!

  • It's worth trying !
    Danielle (Verified Purchase)

    I have been taking TriPlex since October. I did not lose 1 pound the first four months but I lost inches, my clothes fit better, then loose, then baggy. Since February I have lost a total of 14lbs. I have to say though, even if I hadn’t lost anything I would still take it. I have not had my arthritis flair up but once since November (after a month or so on the products), and I can finally sleep! I feel better than I did in my 20’s! You do have to be consistent and drink your water, but it’s totally worth it!

    • Teresa Blizzard

      how long did it take for you to feel better with energy ? I am on month #2 and haven’t seen any changes really. Your thoughts?

    • Connie

      Hi Danielle. I have been on TriPlex for almost a month and I do feel better overall. However, I am in the middle of a bad arthritis flare-up. Sounds like you had a flare-up about a month in as well. How long did yours last and was it a bad one? Just wondering if TriPlex is the cause or if it is just a random flare-up for me.

  • I love it, never felt so better !
    Nineveh (Verified Purchase)

    I love it I never felt bwttrr

  • I like triplex.
    Dawn (Verified Purchase)

    I like the triplex. I haven’t lost any weight but I don’t think it is the products fault. I don’t always follow the amount of water I should be drinking daily. Also, I haven’t been on it that long. I didn’t get in this shape over night so I don’t expect to get healthy overnight. I think it is each individual’s overall health that should be taken into account. It did lower my lipid count and cholesterol levels after three months. I look forward to seeing where my numbers are after a full year. I would never think of Plexus Triplex as just a weight loss system. It was not developed to be just a weight loss product, that is just a benefit for some.

    • Montana (Editor)

      Hi Dawn! If you’re looking for a weight loss supplement, you may want to check out Dietspotlight Burn.

  • Not everyone can take this mix
    Frances Call (Verified Purchase)

    What if I can’t take garcinia Cambodia? It about blew my stomach up

    • Yedy Torres

      Hi Frances,

      We don’t recommend to use this product if you experience those side effects, consult your physician first before using the product.

  • Is this normal?
    Connie (Verified Purchase)

    I am currently on the Plexus Triplex,XFactor and Block. I also am one that has never had a problem having a bowel movement. In fact I have always been regular. (2 or 3 a day)Since taking the products I am having less bowl movements and when I do go it is very little. Getting all my water in and taking the products as it states. Any advice?

    • Yedy Torres

      Hi Connie,

      The product is intended to help you go to the bathroom more frequently, we recommend to consult your physician before continuing with this product.

      • Anonymous

        Do you take biocleanse?

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