Updated: 07/18/2017
By Summer Banks Jul 14, 2017

People are talking about Isagenix. So we decided to take a closer look at the ingredients, side effects, and clinical studies. Additionally, we read hundreds of user comments and reviews. Then, we took this information, summarized and compacted, to give you the bottom line.

Isagenix Readers: Click here to find out why we're giving away samples of our product, Dietspotlight Burn.

What Is Isagenix?

To start, Isagenix is a supplement company offering weight-loss solutions. Products include meal replacement shakes [1], formulas to flush toxins from the body and energy boosters (caffeine). [2] There are supposedly no laxatives used in any cleansing formula, which is a good thing because misuse [3] can cause side effects. [4] Some are taken in the morning and others at night.

The Isagenix products, introduced to the market around 2002, appear to contain natural ingredients, which is always good but it doesn’t necessarily mean they are free for any negative potential. [5] They’re available by phone and from marketing associates. We like the good BBB rating, and the longevity of the company, but read on…

Isagenix Cost – “Over the Top?”

The first concern is the prices associated with Isagenix products. “You can’t put a price tag on weight-loss,” said our Research Editor. “But, there’s a problem when a company charges two or three times that of others.”

“I should have listened to my smarter side before dishing out close to $400 for this product, but I’m only human and fell for the empty promises [which is a problem with multiple companies] [6] that their website offered,” according to one customer.

Another dieter said, “This is an very small jar for the very high price.” This was a complaint from multiple people who chose to buy Isagenix products.

According to several Isagenix reviews, high cost is not expensive to some.

As one buyer says, “Great price/Great product.”

Another stated, “My favorite way to start the day and price is approximately equal to other protein shakes.”

Isagenix Customer Testimonials

Buyer Reviews – “Not Good”

According to several Isagenix reviews, customers complained about the taste, cost, Isagenix side effects and a host of other issues. “All of this stuff tastes nasty. Like a big glass of grape cough syrup,” offers one dieter.

“I didn’t like it. It made me feel nasty. It wasn’t what I expected. Didn’t work for me,” claims a customer.

Just because there are negative comments doesn’t mean that reviews of Isagenix aren’t positive.

“It just becomes a way of life…a healthy way of life,” says one user.

Another offers, “I have had success with weight loss and feeling better with these products.”

In our research, we’ve found a strong connection between poor customer experience or high price, and a negative effect on long-term success. There’s an issue if Isagenix fails the dieter in any way.

The Science – “Evidence to Back the Products?”

Isagenix offers some strong marketing materials, but selling a product is about more than convincing a reader to buy. We look for science, and there’s just nothing on the official website. However, we know from research published in peer-reviewed journals, that meal replacements [7], especially those high in protein and fiber [8] [9], can work to curb appetite by slowing the digestive process. [10] We see the addition of whey, but fiber doesn’t appear to be something the formulas are enriched with. Taking a look at the supplements in the line, you have green tea extract and cayenne. [11] Both have shown promise in terms of facilitating weight loss through increased metabolism.

Also: read our Dietspotlight Burn Weight-Loss Kit review »Isagenix Ingredients

The Bottom Line – Does Isagenix Work?

Has the time come to sprint out for these products? The Isagenix company has longevity on its side and a supportive customer service department, but we have hesitations about recommending the supplements. The company doesn’t bother to share clinical research, though it does exist from testing in a petri dish to animals to humans. Everything is there for ingredients like whey protein and green tea extract. With that being said, just because the support is there doesn’t mean Isagenix products are stronger or better than the competition. That’s one place the business failed to sell us.

If the time has come to shed those extra pounds, we suggest a supplement with a formula packed with clinically tested ingredients, supported by strong customer reviews and backed by a company that goes the extra mile to give all the facts.

Among the best products we’ve seen this year is one called Dietspotlight Burn. It’s made of a proprietary blend of four ingredients. All clinically-tested with results showing it can help jump-start weight loss by increasing metabolism and reducing hunger. You can find dieters who’ve tried it and loved the results offering testimonials all over the web.

Also, they’re so confident you’ll love the supplement, they’re offering a Special Trial Offer, which a good sign.

Previous Isagenix Review (Updated June 5, 2014):

Isogenix Product Line - What You Should Know

Isagenix is marketed as a company that wants to impact world health, according to the Isogenix website. The company has a line of products for cleansing, nutrition, and skin care. Some product lines include 30 Day Cleanse, Ionix Supreme and Isalean. Similar to the Isagenix line, David Kirsch is a a mind-body wellness guru with a line of drink mixes, supplements, and snack bars that promotes a holistic approach to fitness. One of the products in the Isagenix cleansing line, Cleanse for Life, is advertised on other Isa weight loss reviews as a tool for weight loss along with energy and good health. With their abundance of products you can find variations for different health solutions such as weight loss, snacks, cereals, energy and anti-aging. (Take a look at their wikipedia page if you'd like). Other companies that have similar product lines are Yoli Better Body System, Purium and Naturade. The bottles of Cleanse for Life are sold in a two pack, and each 32 ounce bottle is good for two cleansing days. This product appears to be recommended as a part of a complete system designed to cleanse your body over a 30 day stretch. It is also sold as part of the accelerated nine day program, which promises an average weight loss of seven pounds during that time frame. They also have meal replacement options, including shakes and soups. A similar meal replacement product is Prolessa Duo which is an appetite suppressant. The entire product line is available from the official Isogenix website, and also through a network of independent affiliate retailers similar to the classic Avon business model. We are pleased to see that the company provides complete ingredient lists for all of its products, but we are not so inclined to buy into the idea of a complete system with numerous products as the best weight loss method. It's nice to know Isagenix has a favorable BBB rating. We believe that many dieters can find success through a low calorie diet, daily exercise and a single, effective weight losssupplement. Incorporating an exercise routines like PiYo might help in the weight-loss process.

Ingredients in Isagenix Products

The ingredients in the berry flavored Cleanse for Life include a proprietary blend that contains aloe Vera leaf, IsaLyte trace minerals, Pau d'Arco inner bark, suma root, eleutherococcus senticosus root extract, burdock root, fennel seed, peppermint leaf, licorice root, choline bitartrate, inositol, betain HCL and I-methionine. We go over the Isagenix ingredients in greater detail here. Another similar weight loss product that contains aloe vera is Calorad. By the way, it's interesting to view science produced by Isagenix themselves here. We do not see anything on this list that stands out as an effective weight loss supplement. While many of the ingredients may be quite healthy in other ways, we prefer to see an appetite suppressant like Slim Trim U or fat burners like Man Scorch on the list for maximum weight loss benefits. Well known weight loss substances like chromium, green tea, guarana and hoodia are noticeably absent from this list.

Product Features

Some of the Isogenics products appear to be quite pricey, although a double order of the Isagenix Cleanse for Life sells for a reasonable $43 at the time of this review. We could not find any information about a free trial offer or money back guarantee.

The Advantages of Isogenix

  • The idea of cleansing the body from the inside out does offer a number of health benefits.
  • The company provides complete ingredient lists for its products.

The Disadvantages of Isogenix

  • We could not find a money back guarantee.
  • The product we looked at doesn't contain any proven weight loss ingredients.
  • The product is sold as part of a complete package that includes many products and is quite expensive.


We like the idea of an effective cleansing product as a method of jump starting a diet. However, cleansing programs are rarely the best choice for long term weight loss. Another product that states that it cleanses the body is Diurex Water Pills. This particular product doesn't pack much in the way of proven weight loss ingredients to instill much confidence from us in its ability to help dieters lose extra weight. We encourage dieters to look for more effective formulas from other companies for best results.

Isagenix offers a meal replacement shake (IsaLean) that supplies 240 calories, 24g of protein, 24g of carbohydrates (11g of sugar), 6g of fat and 8g of fiber. The milk-based shake is packed with a large percentage of many vitamins and minerals, but there's nothing unique in the formula.

Isagenix Ingredients and Supplement Facts

Serving Size: 2 Scoops
Serving Per Container: 14
Amount per Serving% DV
Exclusive Myo-IsaLean Complex**
- Whey Protein Concentrate**
- Milk Protein Concentrate**
- Low-Heat Nonfat Dry Milk**
Natural Dutch Cocoa Powder**
Isomaltooligosaccharide Powder**
Sunflower Oil Powder**

Other Ingredients: Natural flavors, olive oil powder, xanthan gum, flax seed powder, medium-chain triglyceride oil powder, Ionic Alfalfa leaf extract, potassium citrate, magnesium oxide, tricalcium phosphate, sea salt, enzyme blend, magnesium citrate, silicon dioxide, yucca root powder, vitamin C, magnesium stearate, psyllium seed powder, biotin, selenium amino acid chelate, cinnamon powder, stevia leaf extract, vitamins and minerals

We looked into the Isagenix ingredients to give you the details you need. Below are three of the most used.

Whey Protein Concentrate

Whey protein concentrate is derived from the watery portion of milk that is left behind when making cheese. It has many uses. It is often used for athletic performance or supplemental intake for those who are lactose intolerant.

What Is It Supposed To Do?

Whey protein concentrate is a source of protein that may help improve the nutritional content of your diet. It is possible that it can be used for eczema, allergies, psoriasis, and weight gain in those with HIV/AIDS.

Clinical Research

In a study published in the Current Opinion in Clinical Nutrition and Metabolic Care, “…whey protein may affect glucose metabolism and muscle protein synthesis.” [1] However, they do suggest in the conclusion that more studies need to be performed to gain a full perspective on the substance.

Rhodiola Root Extract

Rhodiola is a plant. Its roots are used for various medicinal purposes. It is often used for energy, stamina, mental strength, and other physical ailments.

What Is It Supposed To Do?

When certain compounds are extracted from the root, Rhodiola is thought to, according to WebMD, “…help protect cells from damage, regulate heartbeat, and have the potential for improving learning and memory.”

Clinical Research

In an assessment performed in Rhodiola published in the European Medicines Agency, “The published clinical trials exhibit considerable deficiencies in their quality. Therefore ‘well-established use’ cannot be accepted.” [2] However, the assessment did acknowledge the extract’s capability to help reduce stress.

Ionic Alfalfa Leaf Extract

Alfalfa is a plant in which its leaves, sprouts, and seeds are used for medicines. It is said that it may help with various ailments, including kidney, bladder, and prostate conditions.

What Is It Supposed To Do?

Alfalfa is supposed to help lower cholesterol, specifically by stopping or slowing the amount absorbed in the gut.

Clinical Research

The University of Michigan’s Health System did some research on Alfalfa and found it may be used for menopause, high cholesterol, and poor digestion. However, there is no word of weight-loss in the information they provided.

We think ingredient research is not just helpful, but necessary. In our research, we’ve found a few products from companies that understand that – like Dietspotlight Burn.

Isagenix is one of those programs that market strong to dieters, so we wanted to learn more about Isagenix ingredients. We took side effects, clinical research and customer comments into consideration. Then, we refined and summarized to give you the bottom line.

What You Need to Know

First off, Isagenix ingredients are divided between shakes, cleanses and weight-loss supplements. Some include whey protein, magnesium, aloe vera, and burdock. Complete lists are available on the official website. The products are designed to be used together to help dieters lose more weight. You can take it on the go, so you don’t have to worry about missing a meal.

The product, offered up by Isagenix International LLC, doesn’t look like it uses any synthetic ingredients, always a good choice. You can buy from distributors only. The official website doesn’t offer sales or prices. We like that ingredients are listed online, and there are some positive reviews, but read on…

Isagenix Side Effects – What to Watch Out For

The first problem we saw with Isagenix weight-loss was hunger. “You can skip meals and reduce calorie intake and feel hungry all the time without this program,” explains our Research Editor. “The difference between a good diet and one that’s bound to fail is control of that feeling.”

“What this cleanse does is starve you for thirty days, encouraging you to consume somewhere in the vicinity of 1,000 kcals on shake days and essentially zero kcals on Isagenix cleanse days,” says one follower.

Another claims, “I only used the Isagenix for 1 week and thought I was going to starve to death.”

High Cost of Weight-Loss

If you want to spend tons of money on Isagenix products, you can feel free to visit a distributor website. “My friend who is an isagenix associate says…it is VERY VErY expensive to maintain,” says someone who knows a distributor.

Another user claims, “I started this 30 day cleanse program, very very expensive and i havent seen any results.”

It takes something small, according to our research, to knock down your chances of long-term success. If the Isagenix diet is too expensive, it may be difficult for dieters to follow over time.

The Science

You’ll spend more than $350 on a weight-loss kit from Isagenix. There’s no clinical research proving this huge price is substantiated. You can purchase meal-replacement shakes and a proven supplement for a fraction of the cost and see results. At DietSpotlight, it’s science that gives us the information we need to give a thumb up or thumb down. In the case of Isagenix ingredients, if they are far too expensive, dieters may need to look for something that’s both affordable and scientifically proven.

The Bottom Line

When we looked deep into Isagenix ingredients, we expected to find exactly what we found. We like that the program includes shakes and supplements, but we can’t recommend any weight-loss plan that expects dieters to pay a huge sum of money for something that shouldn’t cost that much. Plus, we’re concerned about side effects associated with some of the pills.

If you’re ready to take that weight-loss journey, we suggest going with a supplement that packs clinically proven ingredients into an affordable package.

Among the finest supplements we’ve encountered this year is Dietspotlight Burn. With four ingredients in a proprietary blend backed by with published scientific research showing it helps improve metabolism and fat loss, we’re impressed. There are no reports or mentions of negative side effects. We did find numerous reviews claiming some amazing results.

Plus, the product is offered by a company so confident in Dietspotlight Burn that they’re offering a Special Trial Offer, nice addition.

Isagenix Side Effects:

When you think of natural solutions and weight-loss supplements you need to understand the two aren’t always synonymous with no side effects. There is always a possibility for adverse reactions with any formula, although Isagenix side effects are pretty uncommon, with each person comes a different set of tolerances.

Stomach Aches/Pains

Stomach aches or pains are typically swelling or irritation in the stomach or abdomen region. They can range from dull to severe and be caused by some factors.

What causes stomach aches?

Causes can be something as simple as eating the wrong food, or a food item that doesn’t agree with your stomach. It can be caused by stress or anxiety, or an external condition such as gall stones or pelvic inflammatory disease, though rare. [1]


Vomiting is the forced expulsion of the contents of your stomach through the mouth or nose. Typically preceding vomiting, you will feel nauseous, sweaty, and/or experience abnormal amounts of saliva.

What causes vomiting?

Vomiting can be caused by gastrointestinal infections or disorders, ulcers, or irritable bowel syndrome (IBS). Motion sickness, stress, and poor eating habits can also contribute to vomiting, as well as alcohol consumption or overeating.


A migraine is a common headache which can last from a few minutes up to days at a time and can often go along with flashes of light, nausea, tingling in the arms and legs, blind spots, vomiting, and increased sensitivity to light and sound. [2]

What causes migraines?

Migraines can be caused by a pre-existing condition or may be genetic in origin. Wine (and aged cheese) can cause a migraine due to the compound tyramine. You may experience a migraine with aura, which are bursts of neuronal activity proceeded by a span of inactivity.


Constipation can be classified as having hardened stool, fewer bowel movements, abdominal pain, or even vomiting. It’s the inability to pass your stool on a regular basis, often going days at a time without relief.

What causes constipation?

When the colon absorbs too much water, it contracts and doesn’t allow stool to pass normally. When this occurs, the stool is slowed down and dries out due to lack of moisture. If it loses too much water, it will become hard to pass and may obstruct the passageway. Dairy products, lack of fiber, and irritable bowel syndrome (IBS) are common causes of constipation.

Isagenix side effects are few and far between, but there have been reports of vomiting, constipation, and migraines, among some others. To save yourself from issues, you should always seek the advice of a doctor before taking any weight-loss supplement. Specifically, if you are under the age of 18, pregnant or nursing, taking medications, or have a pre-existing medical condition.



Isagenix is a weight-loss company that offers both meal replacements and supplements. There is no shortage of product reviews and, though most mention nothing about side effects, we did find a few here and there.


“My first day of cleanse I ended up vomiting and dry heaving about 13 times. It was horrible. It made me so sick.”    Regina


“I am constantly nauseated. I am weak. I have sharp pains in my stomach all the time.”    Diana


“On my first cleanse day I felt even worse. Stomach aches, head aches, and sooo hungry. On day 2 of the cleanse I started getting very sick (diarrhea and horrible stomach cramps.)”    Justin


“Ended up vomiting before I got to my last dose of the day, plus I felt like a zombie all day. On the second week I was constipated.”    Tonia


“I kid you not, cramping up and down my digestive system and vomit convulsions except there was nothing to vomit up.”   Kat


“It made me so sick and my guess is the high milk content. I didn’t even lose a lot of weight…after two weeks I stopped losing and got really bloated and sickly.”    Tamara


“I’m only on my second day of the Isagenix 30 day challenge and I started feeling nauseous and I threw up. I still don’t feel too well.”    Sarah


“I started Isagenix a couple of years ago. Had a VIOLENT reaction. Throat started burning, mouth burning, one of the worst migraines I had ever had.”    Donna


“I started the 30 Day Cleanse a little over a week ago, and I MISERABLE! For the first 5 days, I felt hungry, I had headaches and waves of nausea.”   Jess


“The product was awful, she tried it and vomited and it made her shaky and sick.”    Ranae


“The supreme shot you take in the AM and the cleanse you do once or twice a week can make you sick, sick sick. Vomiting is an absolute side effect. I thought I was going to need medical attention it got so bad.”    Regina

You’re never going to find a supplement that’s 100% free of side effects. What you’re looking for are customer reviews showing they are extremely rare. Dietspotlight Burn is one like that.

Isagenix is a popular weight-loss system. We wanted to look more closely at a part of the program that comes up time and again – Isagenix side effects. We dug deep, looking at ingredients and clinical research. Then, we condensed the info to give you the bottom line.

What You Need to Know

To begin, Isagenix offers a weight-loss system that consists of shakes, supplements, and a cleansing formula. The program is designed to be utilized throughout the day, helping the dieter lose more weight. All of the products are portable, a great thing for people on the go.

The product line, released around 2002, looks to avoid synthetic ingredients, an excellent choice. You can buy it through an associate or via the customer service department. We like that some people have experienced weight-loss and the company does have years in the business but read on…

Racing Heart – “Wow!”

The first problem we found with Isagenix side effects was increased heart rate. “Stimulants are proven to boost metabolism, so you’ll find them in plenty of weight-loss supplements,” offers our Research Editor. “There are some dieters who can’t handle the amount of caffeine, and other ingredients, in a formula and that’s when Isagenix side effects happen.”

“The accelerator made my heart race, sweat profusely, and very shaky,” says a user who felt some changes.

Another dieter reports the same, “My heart raced like I was dying and I was so jittery I almost went to the hospital.”

Stomach Issues – “Ewwww!”

We also found mention of another Isagenix side effect – stomach discomfort. “Even though I followed the program to the letter, by the end of the week I was very bloated and had put on 2kgs,” explains a user experiencing problems.

”By noon, I’d been physically ill once. By 6p, I couldn’t stop vomiting and when there was nothing left in my system – I dry heaved until 2am,” says another.

Our research shows a direct connection between small issues, like racing heart rate, and a reduced chance of long-term success. If Isagenix side effects are troublesome, the dieter may turn and run.

The Science

The Isagenix website claims the program is “science-based.” We’re not exactly sure what that means because there’s no more information on clinical support. We know research studies have shown a reduced-calorie diet can promote weight-loss, but that doesn’t mean Isagenix is better than other similar products.

The Bottom Line

The potential for Isagenix side effects interested us, and we soon came to a solid conclusion. We like that the company has been around for more than a decade and there are some dieters who’ve lost weight, but we can’t recommend a system that causes negative reactions like racing heart rate and stomach discomfort. We’re also concerned that no clinical research is there to prove this program is better than more affordable ones.

If you’re ready to take a weight-loss journey, we suggest going with a supplement that offers clinically proven ingredients that don’t cause side effects.

Of the products we’ve reviewed this year, one of the best is Dietspotlight Burn. The formula is made up of four ingredients, packaged in a proprietary blend that has been clinically tested and shown to promote metabolism and fat loss. No adverse side effects have been reported, and dieters are talking about seeing some pretty amazing results.

Plus, the makers of Dietspotlight Burn are confident enough in the formula to offer a special trial offer, a good sign.

Isagenix Questions & Answers:

We dug through hundreds of user comments and Isagenix weight loss reviews, for us to be able to write this helpful FAQ.

What are the side effects of Isagenix?

Isagenix side effects may include nausea and weight gain, according to some dieter experiences.

What is in Isagenix?

Isagenix ingredients include whey protein powder, stevia, psyllium [1], various vitamins and minerals, fruit extracts, green tea and apple cider vinegar.

What is the active ingredient in Isagenix?

The active ingredient in Isagenix is whey protein.

What is the Isagenix Cleanse that lasts 9 days?

Isagenix 9 Day Cleanse is a weight-loss / fat burning program that includes a meal replacement shake, snacks, fat burner, and detox.

What is Isagenix 30 Day Cleanse?

The Isagenix 30 Day Cleanse schedule is similar to the 9-day variety. There are a couple of additional supplements and, of course, it lasts three times as long.

Does the Isagenix diet plan work?

The core of the Isagenix diet plan is the meal replacement shakes. Clinical studies do show weight-loss is promoted when using these products. [2] But, there are quite a few supplements in the line, and while some of the ingredients, like green tea extract, have good support, there’s nothing showing these formulas are better than less expensive alternatives.

How much does a bottle of Isagenix cost?

The Isagenix cost is about $50 a week or $200 a month. The other supplements in the line come at an additional cost.

How do you use Isagenix shakes?

You can drink Isagenix shakes up to twice daily. There are many supplements to choose from, and each will have different directions. Typically you will take them one or two times a day.

Can I take Isagenix products if I have a health condition?

Any weight-loss supplement or program, including Isagenix, should be approved by your family physician. This is critical if you are pregnant, planning on becoming pregnant, nursing, taking medications of any kind, are under the age of 18 or have any medical conditions.

What positives can you find in Isagenix diet plan reviews?

Users tend to like that the shake is easy to mix and take on the go. Some even liked the taste.

What about negative reviews of Isagenix shakes and supplements?

On the opposite end of the spectrum, some users did not like the taste of Isagenix shakes at all. There are also complaints about high Isagenix prices.

Can I use Isagenix if I am lactose intolerant?

It may not be the best idea to use Isagenix shakes if you are intolerant to lactose, as they contain milk-based ingredients.

Do I have to use a blender with Isagenix weight loss shakes?

No, you do not need to use a blender with Isagenix weight loss shakes, but you will find the result is smoother with fewer clumps, in some cases.

Who makes Isagenix products?

The makers of Isagenix products is Isagenix Worldwide Headquarters.




There are good supplements out there that offer some support for weight-loss, but our research is to find products that offer more than that. Formulas like the one used in Dietspotlight Burn give you more than many others on the market.

Isagenix Scientific Abstracts:

Whey Protein Concentrate

Studies have indicated that the intake of dairy products is inversely related to a lower risk of cardiovascular diseases and metabolic disorders. Whey protein seemed to trigger the effects due to bioactive compounds such as immunoglobulins, glutamine, lactoferrin, and lactalbumin. Also, it’s a great source of branch chained amino acids. Upon further analysis from multiple reports, whey protein had appeared to contain a blood glucose and insulin suppressing effect partly mediated by incretins. It was concluded that whey proteins could affect muscle protein synthesis and glucose metabolism. The evidence shown in the clinical trials are not reliable enough to make any final recommendations due to a particular dosage and the duration of supplement. [1]

Rhodiola Root Extract

A study published showing the effects of Rhodiola in patients suffering from mild to moderate depression. In the participants involved, overall depression, emotional stability, insomnia, and somatization had improved significantly, while those who took the placebo had shown no signs of improvement. There were no adverse side effects reported in the trials, concluding standardized extract SHR-5 had shown anti-depression potency in individuals with mild to moderate depression when dosed with either 340 mg/day or 680 mg/day over a period of six weeks. [2]


The digestion, metabolism, and absorption of fructose differ from glucose. Unlike glucose, fructose doesn’t trigger insulin secretion nor does it enhance leptin production. Since both leptin and insulin act as important factors in the regulation of body weight and food intake, it’s suggested that dietary fructose may be a contributing factor towards increased energy intake and weight gain. [3]

Milk Protein Concentrate

There are reports of epidemiological evidence revealing intake of dairy products being associated with the decreased prevalence of related metabolic disorders. However, there is evidence from studies showing dairy protein as a dietary function aiding in the prevention of type-2 diabetes. The dairy protein may indirectly increase metabolic health by helping weight-loss and reducing fat mass via enhanced satiety, all while improving skeletal muscle growth and performance through the anabolic effects of BCAAs (branch chain amino acids). These amino acids are shown to enhance lean body mass, skeletal muscle function, and muscle protein synthesis. It was also shown that the composition and processing of dairy protein had a direct impact on the digestion process, concluding that dairy protein in milk may possess ways to maximize benefits for metabolic health. [4]

Learn More About Dietspotlight Burn »
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Dietspotlight, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 3.6. From 675 votes.
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Leave a comment or review

Tobacco interactions

Can I still smoke when i start on isagenix for the 30 days?

Victoria (Editor)

There’s no direct issue with smoking on Isagenix, but it’s healthier to quit 🙂


Guess what? Some people do smoke! Hopefully, the products will help with not smoking!

  Expiration date issues

Are out dated products safe to use?

Maribel (Editor)

Hello Bruce! It is not recommended to use products after their listed expiration date. After the expiration date the product’s chemical composition and strength is not the same. There is even a risk of it developing growth in bacteria! So, there is no safety and efficiency guarantee. So, if you own an expired product, its advised you dispose it and buy a new one.


It depends on whether it is a Use BY or a best by. Use By is usually not best consumed after that particular date e.g.. milk. Best By is a guide and you then need to do the smell look and taste test. If it way past this date then best to err on the side of caution and not use it. If in doubt, throw it out!!

  Hyponatremia interactions
Bill Hardegree

Is this program safe/suitable for persons with history of hyponatremia?


Hi Bill, if you friend request me on Facebook I can invite you to a Facebook page with a bunch of people who use Isagenix. People with all kinds of health issues.

Victoria (Editor)

Hi Bill. Hyponatremia can be a life-threatening condition. Your doctor is the only person who can clear you to start an Isagenix program.

  What else can I take this with?

What do I mix my shakes with water or milk, and can I drink coffee.

Maribel (Editor)

Hi Doreen, you’re free to mix your shakes with anything you want, either water, milk, almond milk, coconut milk or even cashew milk. And yes, you can add coffee too! Just make sure you take a look at the ingredients (sugar, calories, carbs etc.) of everything you mix into it. Keep your goals in mind and don’t be afraid of getting creative. Let us know how it goes!

Z. Hunter

I mix it with water or almond milk

  Ingredient question
rocco f giruzzi jr

Amount of sugar in each of the products?

Victoria (Editor)

Hi Rocco. Each serving of Isagenix shakes has 11g of sugar (24g of carbohydrates).

  I dont understand when to take it

I was wondering why some of their products say don’t take 2 hours before or after medication? as I am on a beta blocker for heart flutters? will it affect this? my doc has no info about this product, but I would like to cleanse and loose weight

Victoria (Editor)

Hi Shawna. When medical conditions come into play, your doctor is the best person to ask. What we do know is this: certain supplements can increase or decrease the effect and potency of a medication. So, when you can, take the product to your doctors and have him see it, so he can properly guide you. Always remember, safety first! Good luck.

Im confused about how to use it..
Sue (Verified User)

When do I take my Synthroid pill? Since they recommend not taking iron,calcium or multivitamin within 4 hours of taking the pill I wondering where to put it in the schedule of all the 30 day program stuff.

Victoria (Editor)

Hi Sue! Synthyroid is a medication that requires a certain finesse. Because of all the rules that go with getting the most out of the medication, give your doctor’s office a call or talk to your pharmacist.

  I dont know how to start

I want to know which part of the program do you start with? I haven’t done the cleanse yet. I have done 2 shake days. Would like advice

Victoria (Editor)

Hi Gracie, there’s no specific place to start. You can buy one or more Isagenix products – mixing and matching. Depending on the supplements you’re using, the “schedule”, so to speak, will change.

Not sure if I should buy it

Hi. I am about to purchase Isagenix does it really work. i am skeptical on using it does it really work. I was looking to see if there are any effects on it. Let me know more thank you.


Victoria (Editor)

Hey Amanda. You can scour the internet, like we have, and find positive and negative reviews on Isagenix products. Some of the ingredients have clinical testing and support. Others don’t. Effectiveness can also differ from one person to the next.


My daughter in law feeds the isagenix chocolate shake to her 2 yr old. I would like to know if this safe

Victoria (Editor)

Hi Gail, Isagenix products are recommended for those 18 years of age or older. The child’s pediatrician should probably talk with mom about this.


like any diet that includes a high amount of protein, you need water!! Gall bladder problems come from lack of water and high protein.

Brooke Snyder

I like somethings about this product BUT it is frustrating to pay SO MUCH MONEY for shipping when you use a large box for a tiny item, i feel this is not Earth friendly and i feel something should be done about this. The products are already expensive but shipping is ridiculous.

Samantha Thorne

Isagenix no longer auto bills, The company cares about its users and bank balances and have listened to what consumers need and want. You can now purchase only the products you choose to with NO lock in contracts and NO auto shipment. LOVE HOW THIS COMPANY WORKS!

Kristy Lee

I tried ISAGENIX and have all of the shakes still sitting right there in my kitchen. I haven’t even opened the other cleanse bottle. And I have ALREADY been to the e.r for gastritis and a UTI.. there is not one thing in my regimen that would have caused this except for the ISAGENIX. After hours of research the shake mix is loaded with garbage ingredients and not at all good for you and 8$ juice. . heck ISAGENIX cost me 350$$. With the right frame of mind. Egg whites for protein. Vitamin. C. B. Good ole classic. Túna fish. Chicken breast. Kale,. blueberries & other HEALTHY meals you can lose weight with plenty of rest and water. I lost 63 once . And was diagnosed with hashimotos and thought that this was a quick fix. Quite frankly .. that’s all these things are. God bless. And thanks for your time


Isagenix simply does not work. I tried it once and lost 9 lbs. Continued to use the product but lost no more weight. About 6 months later thought i would give it another try. Lost 5 lbs. And gained 3 back while STILL ON PROGRAM! Save your money. Eat well and exercise. Its the only way!


good job they offer a money back guarantee for those who are not satisfied! I’m about to go on a 30 day course to see if it helps to improve my ‘well health’ and a condition that leaves me with chronic fatigue.


It’s about lifestyle change. Not just try something once in a while to lose a few pounds. I’ve stayed consistent with Isagenix since February of 2016. I’ve lost 35 pounds, changed my eating habits and feel awesome. I’m committed to lifestyle change not just a quick weight loss gig. It really works if you actually stick to it.


I started using the Isagenix Program end June 2016 and have lost 28 lbs. I have a full time job and the program is extremely convenient for me, I save money on purchasing lunch everyday and I’m fully satisfied. The vitamins and Cleanse for Life taken daily has made a huge difference on the way I feel, if I miss a day I definitely feel the affects. I have absolutely nothing negative to say about this program.


So far it’s fantastic. I used to be a competitive powerlifter, then I got injured and got fat. My biggest concern with any weight lost problem is losing muscle mass and strength. After a week of Isagenix I lost 8 lbs and was actually stronger in the gym on my bench press and incline bench. This program works for me because I am a foodee – I love to eat to my detriment. The shakes fill me up and prevent me from feeling weak. Much easier than doing Adkins – I only lasted a few days. I recommend this program for jocks who have gotten fat.

  Had amazing results !
Diane (Verified User)

I have been on Isagenix for three years and have had amazing results! More energy, greater performance in my workouts, and released 18 pounds! I will be using isagenix products forever! I am now healthier and happier than ever! My daughter lost 75 pounds! She looks and feels amazing! All I can say the program worked for us!


I tried the 9 day cleanse last month and lost 9 pounds. I am doing it again this month and have lost 3 lbs in my first 3 days. The products work fine for me and I love the flavors of the shakes. The cleanse powder does take some getting use to. So far my experience has been positive. I plan on continuing the product until I reach my weight loss goal.


There aren’t any stimulants in Isagenix products, including the snacks. There is a small amount of naturally occurring caffeine in the chocolates. The fructose used to sweeten the shakes comes from low-glycemic beet sugars. It is about the equivalent of what you would find in one small orange.


Hello everyone
I liked isagenix begin with. I followed the program, drank lots of water, lost weight but spent lots of money. Thats just my experience.


I have been on Isagenix for 12 days. Hadn’t changed my diet until I began using Isagenix. Cut my dairy no sugars etc…one meal replacement a day under the required kilojoule intake. Had a pretty massive reaction. Eyes puffed up, and I looked like I got hit by a bus Currently on Prendizone. My intention is the 30 day Cleanse but had a break for two days and now want to continued the cleanse. No proof that this was the cause of the reaction but will see after it takes its course. If i swell up again…then I guess I wont be using it anymore.

Nurse 4 Lyfe

Weight loss can be achieved through a myriad of interventions and Isogenix is only one of them. I recently attended a showing of this product but was “put off” by the lack of knowledge (about the product) from the representative, pushy sales pitch, limited research, and insistence that exercise is not essential for long-term weight loss. Really? The rep insisted that all one needs for successful weight loss is to drink the shake twice daily and eat whatever you want for the third meal! There is no Magic Bullet. I chose to exercise common sense. I will continue nutrition/weight management the “old-fashioned” way by exercising, decreasing carbs and eating a low glycemic diet of fresh fruits/veggies.

Richard (Editor)

We agree that the best way to lose weight and keep it off for good is to make healthy choices and adopt life-long habits that support these choices.


Well the vitamin B is not even real …. man made and they say the reason why it’s cost so much, they use the best ingredients. For this reason I’m having 2nd thoughts. Plus they charge you for pick up etc. Just seams like I can get non-gmo products for less other places. And Isagenix will not put Non-GMO on their containers. So is it or not.


I agree, too much of the sugar. That’s why some people gain weight. And it is true sugar, such as cane sugar and corn syrup! Cannot be healthy. I will try it a little longer, as I want to see that is cleanse, but I do not think I will use this product for much longer.


I’ve purchased products from the company for 3 years and have never had any products missing. I’ve also received excellent customer service each time I called.


Yes, it is very expensive, but if you really follow the instructions it works.
This is the 3rd time I am doing the Isagenix diet: I did it for the first time in September 2013 (30-day), then September 2014 (9-day), and now August 2016 (30-day). I generally lose an average of 9 pounds and it takes me about a year to gain some weight back. Now I am on my 18th day and I went from 150 to 141. I did cheat a bit by drinking wine (which I do not recommend, I really paid the price). I think that otherwise I would have lost more weight.


I”m having great results with Isagenix. Love the shakes, do the cleanse days every so often and have never had a problem with an order.


You can find these products on eBay for less than their retail cost. No real reason to buy it through a rep


A very common mistake in thinking that “muscle weighs more than fat.” It actually doesn’t. 1 lb of muscle compared to 1lb of fat is still 1 lb. The difference is that muscle is more dense than fat so 1 lb of muscle is smaller compared to 1 lb of fat.

: 0

So… it does weight more than fat.
Because whatever you decide to measure will be based in the volume.

  It worked for me !
Nicole (Verified User)

Just as a follow up I was drinking plenty of water, over 100 oz a day and i am under 200 lbs. I went off the product for 6 weeks and did another blood work up and my liver enzymes are back down to normal range. I am not saying this will happen to everyone using the product. I am just sharing my experience and that this was a side effect for ME. Good Luck to everyone on the system.


I actually had the same problem. My liver enzymes went through the roof. I ended up seeing two doctors about this that has advised me to not take this product.


I am about to start my 30day cleanse. I have done other diets like Weight Watchers but I’ve never done a cleanse. I do have anxiety and cannot drink caffeine for that reason. Is there anything in this product that is going to interfere with my anxiety? I am 26yrs old and my goal is to lose 100 lbs by next July.

Victoria (Editor)

Hi Aimee. Isagenix is the company – what product are you taking?