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Isotonix Review - 14 Things You Need to Know

Isotonix offers you the maximum benefit from vitamins and nutrients. The company’s supplements range from weight loss aids to wellness products and multivitamins. We soon discovered they all come with a considerable price tag, however, making it a poor option for those trying to stay on budget.

Most of their products range from $60-100+, and our researchers found many cheaper alternatives on the market. In the bottom line, though, we gave them the benefit of the doubt and compared Isotonix’s “quality” ingredients to their product claims to see if this company is worth investing in.

Isotonix can be purchased through their Official Site.

Isotonix Readers: Noom is offering our readers a 14-day trial, for a limited time. Click here for this special offer!

What is Isotonix?

Isotonix is the world’s most advanced nutraceutical that provides supplements made of the highest quality natural ingredients.

The products include scientifically advanced formulas designed to ensure that your body receives the essential vitamins, minerals, and nutrients that it requires for long-term health and optimal nutrition.

It manufactures four essential supplements namely Isotonix OPC-3®, Isotonix Multivitamin, Isotonix Activated B-Complex and Isotonix Calcium Plus.

Isotonix Competitors

Plexus Slim
Usana Essentials Multivitamin
Other similar products: , NeoCell, OneTwoSlim,

How Did Isotonix Start?

Market America, a product brokerage, and internet marketing company, was founded in 1992 by JR and Loren Ridinger. Its headquarters is located in Greensboro, N.C. and the company employs over 650 people as of 2010.

The firm manufactures various products such as dietary supplements, cosmetics, auto care, jewelry, household cleaning supplies, personal care products, custom websites, water purifiers, and weight management products.

In 1993, it started manufacturing Isotonix products and had been manufacturing them since then.

Isotonix Customer Testimonials

Isotonix Claims

Isotonix supplements claim to provide your body with the maximum benefit they can receive from vitamins and minerals. It offers a complete array of products such as multivitamins, weight loss supplements, and wellness products, which are perfectly designed to fit your needs and offer unique health benefits.

How Does Isotonix Work?

The term Isotonic refers to having the “same pressure.” That means that its chemical makeup is similar to your body plasma, blood, and tears.

Hence, all fluids in your body have a certain concentration, referred to as ‘osmotic pressure.’

The body’s standard osmotic pressure is isotonic.

According to this logic, a substance entering the body has to be in the isotonic state to be absorbed, transported and readily available for usage in the body’s metabolism.

Isotonix dietary supplements are delivered in an isotonic solution, unlike pills that take time to disintegrate, and for their contents to be fully dissolved and transformed into the proper isotonic state.

During this time much of their activity is lost. During digestion, the essential micronutrients in pills and capsules can get trapped by fats, fibers, and tannins, or inactivated by the highly acidic pH level of your stomach.

However, Isotonix supplements are already in disintegrated powdered form. This means that less work is required to obtain maximum absorption and therefore, the nutrients are transported directly into the small intestine and quickly absorbed into the bloodstream.

When the Isotonix products are consumed in this fashion, the supplements do not lose their nutritive value and make the absorption of nutrients highly efficient while delivering maximum results.


Isotonix Ingredients

isotonix ingredients

Isotonix consists of all-natural ingredients that include:

Grape Seed

According to Antioxidants, grape seed extract is typically taken from the seeds of red grapes (instead of white), which contain high levels of oligomeric proanthocyanidins (OPCs) complexes. Grape seed extract is extremely rich in antioxidants.

It contains the polyphenol-a compound, with high antioxidant activity.

Red Wine Extract

Red wine extract is a powerful antioxidant that is present in seeds, stalks, vines, and roots of grapes, with the highest concentration in the skins.

The antioxidant properties of red wine extract can help to maintain healthy circulation by strengthening capillaries, arteries, and veins.

Drugs.com reports that Resveratrol present in red wine extract help enhance memory and enhance joint mobility.

Pine Bark

Pine bark extract is an all-natural combination of procyanidins, bioflavonoids and organic acids. Most importantly it consists of a potent antioxidant compound called pycnogenol.

The extract’s antioxidant properties selectively bind to collagen and elastin and promote the production of endothelial nitric oxide, which is responsible for the dilation of blood vessels.

It also helps support healthy blood platelet activity, alleviates menstrual cramping and abdominal pain, maintains joint flexibility, ensures healthy sperm production supports a healthy complexion.


Bilberry extract is derived from the bilberry plant that has bright green leaves and bell-shaped flowers and is grown in northern Europe. It is closely related to blueberry, huckleberry, and cranberry.

It is rich in pigments known as anthocyanins, which are powerful antioxidants.

Scientific studies confirm that bilberry extract supports healthy vision and venous circulation.


Citrus contains disease-fighting antioxidants called bioflavonoids. According to Food Chemistry, they are scientifically proven to help maintain healthy circulation, reduce obesity and demonstrate anti-inflammatory activity.

Isotonix and Weight Loss

isotonix weight loss

Isotonix supplements consist of all natural ingredients that help you to achieve long-term health and fitness goals. They do not contain any ingredients that cause weight gain or stimulate hunger cravings.

The multivitamin supplement provides you with the right amount of nutrients that your body requires. It helps to boost your metabolism, providing you with a healthy skeletal system and muscle contractions, while increasing your energy level.

Hence, you can enjoy your workout sessions for a longer period and trim down your fat quickly, without easily feeling tired or fatigued.

Product Line

Isotonix Products

All of the Isotonix products have the following properties in common:

  • Gluten-Free
  • No detectable GMOs
  • No artificial preservatives
  • No Fillers
  • Vegetarian
  • Isotonic-Drinkable supplements

Isotonix supplement products include:

Isotonix OPC-3®-Single Bottle (30 Servings)

Isotonix OPC-3 is a dietary supplement that contains some of the most powerful bioflavonoids (scientifically known as oligomeric proanthocyanidins or OPC-3), currently known to research scientists.

The purest and best-researched OPCs have extracted bilberries, grape seed, and red wine.

Pycnogenol, a powerful antioxidant, is extracted from citrus fruit and pine bark.

Isotonix OPC-3 has been shown to provide a variety of health benefits including, but not limited to:

  • Combating free radicals
  • Showing anti-inflammatory activity
  • Maintaining healthy circulation
  • Strengthening capillaries, arteries, and veins
  • Enhancing joint flexibility
  • Alleviating menstrual cramping
  • Supporting visual health/visual activity
  • Promoting healthy blood vessel dilation
  • Promoting healthy nitric oxide levels
  • Supporting a healthy skin complexion
  • Promoting healthy platelet activity
  • Promoting healthy sperm quality

Isotonix Multivitamin with Iron-Single Bottle (30 Servings)

All natural Isotonic Multivitamin contains 100% or more of the recommended daily value of essential vitamins and minerals, hence providing you with the maximum nutrients that your body will require while replacing dietary deficiencies. It offers a wide array of health benefits that include:

  • Enhancing normal cognitive activity
  • Promoting skeletal, muscular & skin health
  • Promoting the conversion of food into energy
  • Promoting healthy growth and repair of tissue
  • Actively metabolizing fats and carbohydrates to support fat loss
  • Supporting a robust cardiovascular system
  • Supporting strong bones

Isotonix Activated B-Complex-Single Bottle (30 Servings)

This supplement contains high levels of vitamins B6, B12, and folic acid, which help in boosting vitamin B levels in your body. As a result, offering you a wide array of health benefits that include:

  • Increasing energy and fuelling optimal energy production
  • Promoting a healthy nervous system, bone marrow, and intestinal tract
  • Regulating healthy levels of serotonin, hence decreasing stress and improving mood

Isotonix Calcium Plus-Single Bottle (90 Servings)

This supplement contains high levels of calcium that is essential for:

  • Maintaining strong bones, healthy teeth, and gums
  • Supporting skeletal health
  • Promoting normal regulation of enzyme and hormone production

Superior Quality of Isotonix Products

All the raw materials used to manufacture Isotonix are verified and require a Certificate of Analysis (COA) to be approved. Raw materials that pass this step are subjected to laboratory confirmation of physical characteristics and material potency, followed by microbiological contamination and heavy metals detection.

Each Isotonix product is then carefully prepared and all of its manufacturing records saved in a written format. Every batch is carefully reviewed and approved by Market America’s highly trained quality control personnel. Audits are conducted at the warehouse to detect any damage, and confirm label accuracy, appearance, taste, and identity before selling it on the market.

Each production facility is required to meet GMP (Good Manufacturing Practice) standards by regular monitoring and is approved by either the Food and Drug Administration or the United States Department of Agriculture for their strict adherence to Standard Operating Procedures, employee training, product specifications, and supplier/vendor qualification procedures.

Benefits & Results

Isotonix Benefits and Results

isotonix benefits

Isotonix supplements consist of a combination of several ingredients that offer unique health benefits regarding energy, immunity, muscle mass growth and digestion.

It is popular amongst athletes and people who want to get rid of their never-ending fat belly. A lot of users take it before work out sessions as it boosts their energy levels and provides them with maximum strength and stamina.

A high quantity of vitamins provides you with high immunity against diseases and boosts your overall metabolism.

It is also a beneficial supplement for older people and helps them manage daily tasks without any complaints about muscle contractions and feeling fatigued, hence providing a healthy quality lifestyle for people of all ages.


How to Use (Take) Isotonix

All Isotonix supplements come in powdered form and need to be properly mixed with water before drinking.

To ensure that the isotonic solution flows immediately into your small intestine, make sure that you take it on an empty stomach.

This process helps in utilizing the supplement more efficiently due to the increase absorbability, hence giving optimum desired results.

Why is Gastric Emptying Time Stressed When Talking about Isotonix?

Nutrients that are already isotonic do not need to be broken down into an isotonic state. Therefore, gastric emptying occurs more rapidly. Biological sensors in the gastrointestinal tract detect that the ingested solution is isotonic and at a correct pH. This causes the pyloric valve at the lower end of the stomach to remain open, allowing the concentrated solution to be squirted into the small intestine by stomach contractions. Absorption of the nutrients by the intestinal mucosa then starts to occur.

Isotonix products have been carefully formulated to clear your stomach at an optimal rate to maximize absorption. A pill does not fully deliver into your bloodstream the vitamins it holds within. Either the pill is dumped whole into your intestinal tract or the active ingredients pass through without being fully absorbed.

Vitamins taken in isotonic form do not have these shortcomings. Thus, it is necessary to consume Isotonix supplements on an empty stomach.

Product Warnings

Isotonix Product Warnings

Isotonix products are free of harmful chemicals, preservatives, and alcohol.

For optimum results stick to taking Isotonix with water. Avoid mixing it with soda, milk, juice, coffee, tea, etc. It should be stored in a dry and cool place, ideally in a dry cabinet.

Avoid keeping it in your bathroom and keep out of children’s reach. If you are storing it in the kitchen, make sure it is far away from the sink, stove, window ledges, and heat generating appliances.

If the weather conditions are very humid, you may keep it in the refrigerator but far from the fruit and vegetable area because this region has high humidity. Note that moisture from the air quickly condenses on cold items taken out from a refrigerator.

The sugars in the supplement quickly absorb moisture and cause hardening of the power, commonly referred to as ‘caking.’

Return Isotonix products immediately back into the refrigerator after using.

Make sure you clean and dry the screw cap’s threads before putting the bottle back into the refrigerator. Any amount of moisture will accumulate on the bottle resulting in caking. Ensure the cap screw is tightly closed at all times and avoid leaving it open for more than a few minutes.

If you note that the powder is hardening, shake the bottle contents a few times during the cool down period. This will help prevent it from hardening into a solid mass.


Any Isotonix Lawsuits?

isotonix lawsuits

In 1999, Market America and its CEO faced certain charges imposed by the United States Security and Exchange Commission concerning how the Company started in 1994.  The Company was accused of selling unregistered Market America stock.

However, the case was settled after Market America paid a heavy fine of $100,000 and a payment of $235,498 to SEC.  The firm did not admit or deny any of the allegations. In 2001, the firm’s CEO settled to avoid any future violations of the federal securities laws, and the company was privatized.

On March 3, 2006, Steve Sawyer sued Market America for failing to pay him for $8,333.34 in monthly services and a $25,000 bonus.

In 2007, the court ruled in favor of Sawyer’s claim that Market America went against the North Carolina Wage and Hour Act by violating its workers’ rights. Sawyer appealed the decision to the North Carolina Court of Appeals, which ruled the trial court’s decision in favor of Market America in June 2008.

Sawyer appealed to the North Carolina Supreme Court and was denied review on December 11, 2008.

Based on the same facts as the North Carolina lawsuit, Sawyer filed a lawsuit against the firm in Multnomah County, Oregon on December 26, 2008.

Moving into 2009, Market America decided to take the North Carolina lawsuit to trial. Sawyer filed a motion to stay the North Carolina lawsuit, which was granted.

Later that year, Market America filed a motion to stay the Oregon lawsuit, which was granted.

In 2010, Sawyer was denied the review to keep the Oregon lawsuit in the Oregon Supreme Court.

In a 2017 federal lawsuit, Market America was accused of violating the Racketeering Influenced and Corrupt Organizations Act and California state law.

The suit claims that the company is very biased and targets only Chinese-American immigrants for their own money-making business.

By doing this, it aims to sell products to their friends and relatives in Asia. The lawsuit characterized Market America’s business practice as “racketeering” and accused that “while the executives tell distributors they can earn more than $560,000, only those at the top make that kind of money. Ninety percent of sellers do not receive a penny”.

Isotonix Alternatives

Many other companies produce a similar product to Isotonix, as listed below. They all contain natural, high-quality ingredients, ideal for achieving your targeted weight loss and fitness goals.

They do this by suppressing appetite and providing an explosive amount of energy to users, to perform intense physical activity and workouts without feeling hungry or fatigued.

Following is a quick list of some of the best-related diet pills:

  • Phenocal
  • PhenQ
  • Lipozene
  • Slim Optimum
  • Adiphene
  • Lipozene

What Users Are Saying

“I take this every morning for my fibromyalgia. I have tried many different things over the years to help with the stiffness and pain, Isotonic OPC-3 has given me my life back.”

“This product was recommended to me but I don’t see any difference in how I feel.”

“Okay but too pricey.”

Bottom Line

The Bottom Line on Isotonix

So, the last of the facts have trickled in. What’s our take on this one? We like the fact that Isotonix has been on the market for over ten years and that it seems to have developed a cult-like following. We also like the results that some users have seen and that the product is readily available, but we have reservations recommending this because of the more affordable alternatives on the market that accomplish the exact results. We’re also concerned about the inconvenience of mixing the powders.

If you’d like a convenient, affordable way to lose, we suggest a program that provides healthy and steady weight-loss and is backed by multiple clinical studies.

Among the best programs we’ve seen this year is one called Noom. This weight loss system provides its users with everything they need to start losing weight the right way, like human coaching, personalized meal plans, and support groups.

The makers of Noom are currently offering Dietspotlight readers a  [promoted_product_off_link], which is a sign that they’re confident in their program.

Learn More About Noom »
Isotonix Review
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What is OPC 3 Good For?

Isotonix OPC-3 is an antioxidant and isotonic-capable dietary supplement that combines citrus extract, bilberry, red wine, and grape seed extracts. It is also the only isotonic form of Pycnogenol, which is the U.S. registered name given to the pine bark extract, which helps to reduce inflammation and varicose veins. It relieves arthritic pain, improves skin appearance, supports the immune system, and has cardiovascular advantages.

What is Isotonix multivitamin?

The Isotonix multivitamin is a preparation of vitamins and dietary minerals. It is available with or without iron added.

What is Isotonix digestive enzymes good for?

The Isotonix Digestive Enzyme formula helps control cholesterol levels, supports a healthy gastrointestinal tract and immune system, aids in digestion and in the absorption of nutrients.

What are the side effects of Isotonix?

Isotonix products side effects may include headaches.

What are the ingredients in Isotonix?

Isotonix ingredients are chromium, l-carnitine, pycnogenol, resveratrol, acai, coenzyme Q10, vitamins, minerals and lutein. The formulas differ depending on the supplement.

Where can I buy Isotonix?

Isotonix can be purchased using their Official Site.

Does Isotonix work?

There are no scientific studies linking Isotonix to weight-loss. We did find research into some active ingredients, like chromium, but that ingredient is used in other products.

How much does Isotonix cost?

Isotonix costs vary by supplement. The weight-loss supplement costs $41.95.

How should I take Isotonix?

You should take Isotonix based on the supplement purchased.

When is the best time to take Isotonix digestive powder?

The best time to take Isotonix digestive powder is in the morning.

Do Isotonix products contain soy?

Yes, several of the Iso products contain soy.

Does Isotonix come with a guarantee?

Isotonix comes with a guarantee. You’ll receive a return authorization and send the unopened item back for a full refund.

33 Isotonix Reviews

  • Virginia

    I’ve been having nightmares since I started taking Isotonix Opc-3 a couple of weeks ago. I usually never dream or remember having a dream, but now i almost every day have nightmares.

  • Norma

    I tried opc3 and made my stomach burn and made me tingly. Stoped taking it and took a while to recuperate

    • Adrian (Editor)

      Hello. All users are different and can experience different results; please make sure to consult with your physician before continuing this product to make sure its safe and effective for you to use.

  • Eric

    Has anybody had a bad case of acid reflux after taking isotonix vitamins.
    I tried the multiple vitamin twice over 6 months and both times after about 3 weeks, I lost the taste in my and got acid reflux

    • Adrian (Editor)

      Hi Eric! All users are different and can experience different side effects; please make sure to consult with your physician before taking this product again.

  • Your NameHEATHER


  • Alex

    I was wondering if anyone has taken the activated B Complex, and if so did they have side effects, or any negative issues?

    • Stephen (Editor)

      Anyone had issues?

      • Brandy

        The B-Complex changed my life. I had more energy and it helped to calm stress unbelievably! B vitamins are depleted with stress and sugar. 🙁 I have and love both! I absolutely love isotonix and take many of the other supplements as well.

    • YC

      Activitated B change my life .I had severe migraine for more than 25year. ( Didn’t know that I am a B deficiency.)
      I never believed in supplements as it give me migraine when I take them. I was amazed that my migraine instantly lifted in 20 min after 2 doze , in the past I be down for at least 3 day. I am migraine free now. After 1 year on ( essential kit ) l look ten year younger.

  • Contains Cobalt or Chromium
    Mike Thanasoulis (Verified Purchase)

    I v e been taking this for close to ten years along with the acai.I was told by Dr. to sop taking the Acai because of the Chromium/Cobalt in it.I have high levels in the blood due to Metal on Metal hip replacements.My Question is does the OPC3 have any Cobalt or Chromium in it? I would like to keep taking it.I do miss the Acai.And would like to continue taking the OPC3. But not if it Contains Cobalt or Chromium.Thank You

    • Stephen (Editor)

      It seems the formulation consist of Natural fruit extracts and flavonoids; no mention of metals like cobalt or Chromium, Mike!

    • Judy

      Isotonix OPC 3 has no cobalt or chromium. It contains Grapeseed extract, Bilberry extract, and Pinebark extract. A powerful antioxidant. Look it up on Istonix.com for the ingredient list. A terrific product with many benefits.

  • Is this safe for people with Diabetes?

    Are Isotonix supplements safe for diabetics? I take Ultimate Longevity Formula and Maximum ORAC. They both VERY sweet.
    Ultimate Longevity formula contains soy. Soy is not organic,is it?

    • Juli

      Soy can be organic. I believe (which can be verified if you call there 800 number and speak to product specialist) they use the highest quality they can find that isn’t registered legally as ‘Organic’, however.

  • Is this good? Any side effects?
    Michelle Romaniszyn

    Hello. I recently sat in on a presentation on Isotonix Opc-3 and is benefits on your health as well as nutritional supplements and other products. My question is, Is this really a good product and are there any severe side affects. I don’t want to spend alot of money on something that isnt any different from another detox system. I am looking to detox my body, rather cleanse my body of toxins. I’ve never had a cleaning done before. What are your thoughts?

  • Which is the best for me?

    Isotonix was recommended to me and I’ve been doing some research on the product, but still have questions. I’ve suffered from acid reflux for quite some time, but lately, it was gotten really bad. One doctor thinks it could be the start of an ulcer and wants me to have an upper GI endoscopy. However, before opting you have then shoe a camera down my throat, I’d like to try Isotonix, as I’ve read excellent reviews about the product. My question is though, which one works best for acid refux..the digestive health or the OPC-3? I’ve also read about people taking the OPC-3 along with aloe vera juice. There are so many choices, I don’t know which one to go with. Please help me!! I need relief asap.

    • Jeannie

      Hello, I was introduced to opc3 3 years go because of acid reflux any food I eat will have a burning like feeling. I started taking it after one week I didn’t feel the burning in my chest.Awesome but it didn’t stop there I was sleeping better. I feel great. It help me so much I am happy.
      Isotonix .

      • Phoebe

        Full disclosure here: I sell Isotonix.. but only after taking OPC-3 for a few months and finally getting off the allergy meds I had used since I was a teenager. Since then, they’ve helped my mom reduce her high-blood pressure meds, helped my husband with joint pain, helped a friend with acid reflux and countless other benefits as a natural anti-inflammatory. I think it is expensive – but you get what you pay for – they have 3rd party quality control which means that you can trust what is on the label is IN the bottle…. (not true for MANY other companies (did you watch the Frontline piece out in Jan? Yikes.)

    • Your Name

      OPC and Market America’s other vitamins made my acid reflux worse

      • Lydia

        Try Ultimate Aloe juice, pls.

    • Maggie

      Definitely try the digestive enzymes and the ultimate aloe! Sometimes the other Isotonix can cause acid reflux, but it really is a case-by-case trial. If I take them on an empty stomach then they always give me acid reflux. I would only recommend the digestive enzymes and the ultimate aloe until you start to see some results.

    • Jeng

      Take the aloe juice

  • Weight Increase Side Effects
    Janet Lee (Verified Purchase)

    May I know is weight increase a side effect after taking isotonix. I have started for about 2 months. Tks

    • Dale

      The products provide supplemental nutrients, there are no side effects.

    • Tina

      I’ve been taking the powder packets daily for a month. First, my energy level increased tremendously, Second my joint pain decreased to non-existent, Third, my inflammation is much better and I’m losing a bit of weight. I recommend it to everyone I meet. OPC3, multivitamin, b-complex and calcium-plus are all in one packet. I disagree that the price it too high when I get these results! I sip it down with my big bottle of water at work. And I take it on usually on a full stomach – doesn’t seem to make a difference. No acid reflux or upset stomach. I’m an advocate!!! GET THIS STUFF – especially if you’re older and creaky!

  • Felt Some Side Effects
    William Thompson (Verified Purchase)

    I committed to myself and my wife to lose weight and take the Isotonixs she purchased for me. However, after taking this stuff for several days, I had to quit. I agreed to continue the diet, but each time I took this stuff, I felt a lot of pressure in my head, couldn’t focus my thoughts, felt dizzy, and my vision went somewhat out of focus. So much for Market America. I wish she could receive a refund. She spent several hundred dollars.

    • Dale

      What products are you taking, what portion sizes are you taking and how does your wife feel when she takes the products? If you are by any chance allergic to a product you can get a bad reaction such as what you’re describing and it doesn’t mean the product is bad since no one else is having the same reaction. The products are made from natural fruit, and vegetable extracts but some people do have food allergies so your claim cannot be discounted, the solution is to determine what you’re reacting to.

    • Est

      I too have noticed the blurry vision and dizziness after taking opc-3. I had to pull books away from my eyes to see the lettering right. And had that feeling you get when you are a tad congested in the head and a little flush and fuzzy. Today will be day 3 and I am going test if I get the same reaction after taking it. If so I’m returning.

  • Madi (Verified Purchase)

    I took isotonix for 1 month and I gained 4 lbs instead of losing. Should I continue or stop taking?It worked for my friend, I am not sure why it’s not working for me. It’s expensive and I have 1 more sealed bottle.

    • Victoria (Editor)

      Hi Madi! We’re sorry you weren’t able to achieve the results that you wanted from Isotonix. Have you looked into other weight-loss products? You should check out !

    • Victoria (Editor)

      Hi Madi! We’re sorry that you weren’t able to achieve the weight-loss results you wanted from Isotonix. Have you checked out Burn HD?

    • Rick

      Isotonix is not a weight loss regiment, but rather a dietary supplement to give your body, in a very high absorbable format, needed vitamins and minerals that our diets don’t or can’t provide. It is possible to lose weight using Isotonix, depending on your body, but that’s not what they are geared for. If you’re interested in losing weight, talk to who supplies your Isotonix for what products are geared for weight loss. If they can’t help you any further, find a new distributor.