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Protandim Review - 12 Things You Need to Know

Protandim Nrf1 and Nrf2 is a two-part dietary supplement that has been receiving a lot of attention. It is designed to increase cognitive performance and reduce oxidative cell damage that contributes to the aging process. In the ongoing quest to discover what dietary supplements work and which ones don’t, our research team was tasked with performing an in-depth analysis of the product, its ingredients, possible side effects and performance.

Our team wanted to know if the official website made any claims that were dubious or unrealistic. The research team took a close look at any available clinical research on Protandim and its ingredients. Our team’s analysis also accounted for hundreds of past and present consumer reviews and experiences. Our team summarized their findings here to provide you with just the facts.

Protandim can be purchased through their Official Site.

Protandim Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Protandim?

First off, Protandim is two different health supplements: Protandim NRF1 Synergizer (released first) and Protandim NRF2 Synergizer. Together, these products aim to boost cognitive performance and brain health and reduce oxidative stress that contributes to aging.

We all experience cellular stress through the process of living (eating, sleeping, breathing, and exercising), and Protandim aims to slow this down.

Both are available over-the-counter but help in different ways. Here is a better look at what each supplement contains:

Protandim NRF1 Synergizer (original breakthrough formula)

  • Acetyl L-Carnitine
  • Quercetin
  • Grape Extracts (skin, pulp, seed)
  • Alpha Lipoic Acid
  • CoQ10

Protandim NRF2 Synergizer (new breakthrough formula)

  • Milk Thistle Extract
  • Bacopa Extract
  • Ashwagandha Extract
  • Green Tea Extract
  • Turmeric Extract

Update 2020: Protandim has expanded its line to include a Tri-Syngizer, NAD Synergizer, a Vitality Stack, and Activated Essentials, in addition to their main two products. These range from $49.99 to $239.99/month.

Does Protandim contain caffeine?

Yes, Protandim contains 1.8 mg of caffeine per tablet.

Also, each Protandim supplement is 100% vegetarian and free of allergens such as dairy, wheat, gluten, yeast, and gelatin. This makes it easier for people with allergies to use these products safely.


Before we get started digging through all the detailed research on Protandim, we wanted to touch base on the idea of supplements for cognitive improvement. Does this formula show promise in clinical study?

  • Antioxidants – “Protandim, a combination of five herbal ingredients, potently protects against oxidative stress.” However, the research was only done on individual cells, making it difficult to determine if these effects would happen in the body.
  • PLOS One – Found that Protandim had no significant effects on running time, oxidative stress, antioxidant levels, or quality of life in runners.
  • Journal of Applied Physiology – Research also shows Protandim may support proteostasis, which “is a key mechanism for preserving cell function.”

Protandim Competitors

Plexus Slim
Thrive Patch
Juice Plus+
Other similar products: CleanseSmart, Zeal For Life,

Protandim Benefits

Now for a closer look at the actual benefits of LifeVantage Protandim. Each supplement has different things to offer, and the official website does a good job of elaborating on the effects of these formulas.

Protandim NRF1 Synergizer Benefits

  • Increased mitochondria production
  • Improve performance through energy production
  • Enhance cellular health – cells function at peak performance
  • Reduced cellular aging
  • Promotes better sleep quality and promotes cellular repair
  • Increase cellular energy (ATP)

WARNING: Not for use by individuals under the age of 18.

Instructions: Take two tablets with food and a glass of water in the morning.

Protandim NRF2 Synergizer Claimed Benefits

  • Help body detoxify
  • Help body repair and rejuvenate its cells
  • Reduces cellular stress (through NRF2 activation)
  • Produces enzymes that combat harmful free radicals
  • Lowers oxidative stress by 40% in only 30 days

Instructions: One tablet daily with food (for adults)

Dual Synergizer Claimed Benefits

  • Turn on natural antioxidant production
  • Repair and rejuvenate cells
  • Protect cells from free radical damage
  • Promotes cellular repair
  • Boost cellular health
  • Improve sleep quality

About LifeVantage

LifeVantage Corporation is the multi-level marketing (MLM) company behind Protandim products. This company has been in business since at least 2003 and has a solid A+ rating with the Better Business Bureau.

The scientist behind this supplement is Dr. Joe McCord. He was once a Chief Scientific Officer. According to the company website, Protandim appeared on Primetime in 2005.

Back then, it was sold in retail stores but is now available more exclusively through authorized dealers.

In 2012, the company announced a voluntary recall and replacement of select lots of Protandim due to a potential health risk of metal fragments in the final product as a result of contaminated turmeric extract.

Here is the corporate contact info that’s presented on the official website:

LifeVantage Corporation

9785 S Monroe St Ste 300

Sandy, UT 84070-4292

Phone: 1 (866) 460-7241

LifeVantage Company Chart

  • Type: Public
  • Industry: Multi-level marketing (MLM) company
  • Founded: 2003
  • Headquarters: Salt Lake City, Utah, United States
  • Products: Dietary supplements, skincare
  • Website: www.lifevantage.com

Other products offered by this brand include supplements for beauty, fitness, pets, and other nutritionals, some of which are as follows:

  • AXIO (regular and decaf)
  • LifeVantage Omega+
  • Petandim x3

PhysIQ Products

Protandim and the FDA

In January 2017, the FDA sent a warning letter to LifeVantage regarding Protandim. According to the government agency, LifeVantage was selling the product as a drug, not a supplement. The wording has since been changed, and now LifeVantage complies with certain laws, according to the Food and Drug Administration.

Protandim Research

There is some science presented on the official website that supports Protandim’s results.

As for Protandim NRF2 Synergizer, there were actual studies conducted showing that this health supplement can activate the NRF2 protein, provide protective antioxidant enzymes, and reduce oxidative stress levels up to 40% in only 30 days.

Protandim research

What’s more, this formula elevates glutathione by 300%, superoxide dismutase by 30% and catalase by 54%.

Also, there is substantial research that supports the antioxidant ingredients in this supplement. These ingredients include grape stem/fruit, quercetin, coenzyme q10, alpha-lipoic acid, green tea, and milk thistle.

What’s more, this formula elevates glutathione by 300%, superoxide dismutase by 30%, and catalase by 54%.

Also, there is substantial research that supports the antioxidant ingredients in this supplement. These ingredients include grape stem/fruit, quercetin, coenzyme q10, alpha-lipoic acid, green tea, and milk thistle.


Protandim Ingredients

Let’s hone in on the product’s ingredients to understand better how these health supplements work.

Ingredients include:

  • Milk Thistle
  • Bacopa Extract
  • Ashwagandha
  • Green Tea Extract
  • Turmeric Extract


According to the National Institutes of Health, calcium is an important mineral found in kale, milk, almonds, cheese, broccoli, and tofu.

Turmeric extract

A plant that commonly grows in India, South America, and some other parts of Asia. It’s often used as a food spice and is related to the ginger plant.

Also, turmeric has been approved in some countries to aid with digestive problems such as gas and bloating, according to Clinical and Experimental Pharmacology and Physiology.

Protandim ingredients - turmeric

Milk thistle seed

Also called holy thistle, this is a herb that contains a flavonoid called Silymarin, which has antioxidant effects.

Ashwagandha root

Sometimes called Withania somnifera, or Indian ginseng, this root is often used in Ayurvedic medicine, according to the African Journal of Traditional, Complementary, and Alternative Medicines.

Bacopa monnieri herb

A herb that is often used in over-the-counter nootropic supplements.

Green tea leaf

Also called Camellia Sinensis, this plant contains both caffeine and EGCG (catechins). It’s consumed as a beverage and has been tied to health benefits, according to research published in the Proceedings of the Japan Academy, Series B.

Protandim ingredients - rhodiola rosea

Rhodiola Rosea root

A Scandinavian herb that is often used in traditional Chinese medicine. It’s typically claimed to boost cognitive function, promote longevity, and reduce mental fatigue, according to BMC Complementary and Alternative Medicine. This substance is found in many over-the-counter nootropics.

Alpha-lipoic acid

A potent antioxidant found in foods like potatoes, broccoli, tomatoes, spinach, yams, and yeast. It is said to boost the health of the immune system, aid with weight loss, and protect the body from harmful free radicals, according to Nutrition in Metabolism.

Coenzyme Q10

An antioxidant found in plants, animals, and people. It’s important for proper cell function and producing energy for the body, according to the Journal of Pharmacy & BioAllied Sciences.

Protandim ingredients - Quercetin


A plant polyphenol and bioflavonoid found in various grains, fruits, and vegetables, it is often added to manufactured beverages, supplements, and food products.

Grape stem and fruit extract

According to the International Journal of Food Properties, this fruit and stem extract provides antioxidants (bioactive polyphenols) to ward off free radicals and reduce oxidative stress.

Side Effects

Protandim Side Effects

As with any dietary supplement or health product, it may cause some mild side effects. After looking at all sorts of LifeVantage reviews posted online, here are the effects you may notice while taking this product:

  • Nausea
  • Upset stomach
  • Digestive issues
  • Headaches

According to the U.S. National Library of Medicine, ashwagandha can cause diarrhea, upset stomach, and vomiting.

Protandim side effects

It is also specified on the official website that Protandim is not for individuals under the age of 18, nor is it for women who are pregnant or nursing a child.


How to Take LifeVantage Protandim

The bottle’s label directions say to take two capsules of Protandim NRF1 Synergizer with a glass of water and food each morning.

As for Protandim NRF2 Synergizer, the instructions say to take one caplet each day with food. There is no mention of a specific lifestyle change with these products. Therefore it does not expect you to exercise regularly or adhere to a particular diet plan.

However, adopting a healthy diet and exercise program will undoubtedly improve your overall wellness, and you will likely see even better results with Protandim.

Note that you can take Protandim supplements together if you choose. Stacking Protandim tablets with other LifeVantage products is acceptable. These include Omega+ (supports brain, cardiovascular, skin, and immune system health) and PhysIQ Probio (supports a healthy immune system and optimizes digestion).

Where to Buy

Where to Buy Protandim

At this point, you’re probably wondering where you can buy Protandim. It is available on the official website as a one time purchase and subscription.

On the other hand, we did find LifeVantage Protandim on Amazon.

Therefore, some authorized distributors must be selling the supplements through this dealer website. Unfortunately, common retail stores and health supplement shops no longer sell this product.

Protandim cost


Protandim Price

On the official Protandim website, Protandim NRF1 Synergizer capsules cost $59.99 for a one time order and $49.99 if you choose a monthly subscription. Protandim NRF2 Synergizer costs the same. You can also order both for $102.99 as a one time order or $85.99 if you choose a monthly subscription.

As for Protandim’s Amazon prices, NRF1 Synergizer sells for $35.85 with free shipping, and the NRF2 Synergizer goes for $34.50. In other words, both products are around $70 per bottle for a 30-day supply. You can also buy these supplements together on Amazon for $64. The pricing is widely varied and could change at any time, as these offers are from third-party sellers.

As for a return policy, LifeVantage offers a 100% 30-day refund guarantee. However, you must not have opened the product to qualify for a refund.

Protandim Alternatives

People generally get antioxidants from their diet, including vegetables, whole grains, fruits, beans, seeds, nut, legumes, and sprouts.

This helps combat daily stressors and free radical damage caused by lifestyle choices, pollution, diet, and work. It’s common to obtain some antioxidants through supplements as well. This is where Protandim fits into the picture. It provides herbal ingredients that offer protection from oxidative stress.

Some research has shown that antioxidant supplements can be helpful.

Here is a closer look at some alternatives to Protandim. These supplements are all available over-the-counter, and you can find them through online dealers.

  • Pure Therapeutics NRF2 Boost
  • AMRAP Nutrition Super Berries
  • VitaRave
  • Sundown Naturals Stress Formula
  • Stresstabs
  • HUM Nutrition Big Chill

Protandim vs. Thrive

First off, Thrive is a series of products that focus on weight management, whereas Protandim does not claim to help in that field. Protandim is marketed as a “nootropic and stress relief supplement” and doesn’t even demand a special diet or an exercise routine when you are on it.

Thrive, on the other hand, promises “premium support and benefits in the areas of weight management, cognitive performance, digestive & immune support, healthy joint function, lean muscle support, general discomfort, and age-defying & antioxidant support.”

Note that its official website talks about weight management and not weight loss. Therefore, Thrive aims to be a “lifestyle enhancer,” like Protandim, but its focus is on anti-aging and reducing stress levels.

Most important, however, is that there are clinical trials and research to support Protandim’s effectiveness and what it claims to be able to do. Thrive products, on the other hand, have no clinical trials, extensive research, or any concrete science to support its claims.

Protandim alternatives

Protandim vs. Plexus

Plexus products, much like the Thrive line, focus on weight management rather than anti-aging and stress management like Protandim does.

The Plexus website has this to say about one of their most popular products, Plexus Slim: “Slim features a premium microbiome activating formula that contains ingredients clinically demonstrated to improve your gut health and promote weight loss! Feed your gut beneficial prebiotics, support healthy glucose metabolism, and lose weight – all with one great-tasting pink drink.”

Protandim vs. Juice Plus

Juice Plus is a series of dietary powder shakes and bars that contain concentrated fruit and vegetable juices that have added vitamins and nutrients. Some of these include calcium, vitamins C and E, carotenoids, soluble fiber (glucomannan), enzymes, dried probiotics (lactobacillus acidophilus), and folic acid.

Studies that looked into how effective Juice Plus products are at increasing nutrients in the human body have reached mixed conclusions.

It appeared to increase some (beta-carotene, vitamin C, vitamin E, and folate), but, since they were added artificially, it’s not clear if Juice Plus is more effective than other, cheaper products that contain similar amounts of vitamins and nutrients.

Studies on the effects of Juice Plus supplements on reducing oxidative stress and DNA damage, which is far closer to Protandim’s ballpark, have also been mixed. All in all, Protandim does not have a special focus on weight loss or management, so you might want to seek one of these other products if that’s what you’re after.

However, it seems that Protandim is backed by more solid science than any of the other three products we’ve compared it to here. So, if you’re looking to reduce your cellular stress levels and have an anti-aging focus, it’s best to go with what Protandim offers.

What Users Are Saying

What Users Are Saying

“I’ve taken Protandim off and on for the past 7 years. For the first three years I took it consistently but then finances got in the way. I restarted it a couple of years ago when an old knee injury kicked up. It helped but then I stopped taking it again. Once again, my knee problem flared up. I’ve been back on it for six weeks and notice so much improvement. This is a product I really believe in for inflammation and general health, and the price and service from this vendor is excellent.”

“No benefit from this supplement. Won’t be buying again.”

“Protandim is a blend of 5 herbal ingredients that work together to reduce oxidative stress. Because oxidative stress has been proven to create free radicals which causes aging and disease. After taking Protandim for 90 days I noticed improvement with the arthritic pain in my knees.”

Bottom Line

The Bottom Line on Protandim

We must admit that Protandim has quite a bit to offer in regard to clinically-backed ingredients and overall health benefits. We even found encouraging scientific research and numerous positive customer comments around the web. This says a lot about this health supplement. On the downside, here are a few concerns we have about Protandim:

  • This product is not available in stores, and you must buy Protandim from an authorized dealer.
  • There was an FDA warning letter regarding the medical claims on the official website for Protandim NRF2 Synergizer, but it looks like they corrected this issue.
  • These health supplements do not help with fat loss or weight management.
  • If you’re striving to reduce damage from stress, improve health, boost energy and enhance cognitive performance, consider pairing Protandim with a supplement that contains a clinically-tested ingredient combo shown to spark energy levels and promote a healthy weight.

Of all the weight-loss products on the market, the one that stands out to us is Noom. This clinically-proven app was designed by medical doctors and nutrition professionals, so you know you’re getting the right stuff. The app comes with human coaching, personalized meal plans, exercise tracking and a wealth of resources so you get to your ideal weight and stay there.

Plus, because the app has worked for so many people, Noom is offering Dietspotlight readers a free trial offer.

Learn More About Noom »
Protandim Review
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What are the side effects from taking Protandim?

Potential Protandim side effects, according to some customer complaints, include gastrointestinal distress, headaches, and rash.

What are the ingredients in Protandim?

Protandim ingredients include milk thistle, bacopa extract, ashwagandha, green tea and turmeric.

Does Protandim work?

There a several studies listed on the Protandim website. We noticed several dealt with oxidative stress, as well as the antioxidant effect of Protandim ingredients. Based on research and customer testimonials, there’s a chance you’ll have success.

How much does Protandim cost?

Protandim costs $50 for a 30-day supply. If you sign up for the auto-ship, the cost is $40. If you want both, you’ll pay $100/month.

How should I take Protandim?

You should take one Protandim capsule per day. One bottle lasts a month.

Where can I buy Protandim?

Protandim can be purchased using their Official Site.

Does Protandim come with a guarantee?

Protandim does come with a guarantee. You have 30 days to return the supplement for a full refund.

What is Protandim?

LifeVantage’s Protandim contains a patented herb blend that reduces oxidative stress. Supplementation of Protandim was studied in two small human trials.

How do you take Protandim?

Protandim NRF1 should be taken on an empty stomach with a full glass of water. After half an hour, Protandim NRF2 may be taken with food. Each dose is two capsules.

How much caffeine is in Protandim?

There are 1.8 milligrams of caffeine per capsule. In comparison, a “caffeine-free” coffee typically contains between 4-7 milligrams and a Starbucks coffee can contain up to 150 milligrams.

What does Protandim do for you?

Protandim supplements claim to decrease oxidative stress.

Is Protandim approved by the FDA?

Protandim is not approved by the FDA.

How long does it take Protandim to work?

According to Protandim, users should start seeing results after 2 weeks of continued consumption.

Is Protandim organic?

No, Protandim is not certified organic.

70 Protandim Reviews

  • Love The Product
    Marlene (Verified Purchase)

    Love the product am on my 3rd bottle but have concerns. Why am I putting on weight. I have gained 8lbs. The first bottle I lost about 6 lbs, u now have put all back on and more. Please respond.
    Marlene Krueger

    • Ashley Alexis Warrenton-Smith

      If you are buying the product on Amazon, you may be purchasing fake Protandim. LifeVantage has very strict distributor guidelines; they are NOT allowed to sell on Amazon or e-Bay. There are a lot of knock-offs from Asia that are not the same — and could actually damage health.

  • Could
    Marjorie La///bell

    could not find price

    • Shaun McKee

      Protandim Nrf2 is $40 plus tax and shipping.

  • Need information about the ingredients
    Earl D Sorensen (Verified Purchase)

    I didn’t know that the product has caffeine in it. I’m not suppose to use caffeine!! Is their tantium in this product also???

    • Wayne Wood

      It has no caffeine in it. Where did you hear that?

      • Your Name

        Green tea has caffeine.

        • Jane

          It has 4 mg caffeine/dose

          • Pattie

            I read earlier is has 1.8 mg of caffeine which supposedly less than a cup of green tea

            • Kathy

              It equals 75mg of caffeine from green tea. I have a big issue with it. I found myself down in bed with high fever, shaking, heart pounding , bone pain but still being encouraged to continue as it couldn’t be from that. When it’s the exact same symptoms I’ve had with green tea in the past.

              • Jan

                If you have a green tea allergy, I’m surprised you are taking or drinking any foods containing greentea. Why would you do that?!! Always read labels.

    • Abby Beitel

      The very small amount of caffeine is from green tea which normally has half the caffeine of a cup of DECAFFEINATED coffee. It’s miniscule and I wouldn’t let that stop you from taking the best product on the market.

    • Maribel (Editor)

      Hi Earl ! The ingredients in this product are: milk thistle, bacopa extract, ashwagandha, green tea and turmeric. I

  • Eve

    My blood pressure is very high and I’m worried. Will protrandim work?

    • Yedy Torres

      Hi Eve,

      Due to possible interactions we don’t recommend to take this product, please consult your physician to find the right product for you.

    • Jen

      Eve, Protandim reduces oxidative stess which causes many issues with the body. It contributes to over 200 disease processes. Look up the Ohio.State Heart Study on Protandim on YouTube and watch the video. The American Heart Association published the results in their Circulation Magazine.

      • Jeannie

        I have been on the product since May 2011 I use all the products faithfully My blood pressure 117 / 73 i donate biood which one nurse said I wish mine was as good as yours I have a Physiq shake with my omega plus and probio loss some weight but not faithful in following thru have reversed my bone health have a healthy body lots of energy, people think I’m in my 60s sometimes younger but actually I’m 82 and on no meds . my eye Doctor said my eyes are totally healthy what else can I say before protandim eye surgery gall bladder removed I’m dsyleixic (?) and axio clams my bfain My health is great my skin looks young no wrinkles I’m full of energy and I take care of my totally healthy husband (Protandim) but has Parkinsin and has a big problem walking but goes fishing with our son once or twice a week

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