Don’t laugh, but well over 50% of diet products simply don’t work. So what about Protandim? Well, we wrote one of our in-depth reviews, scrutinizing the side effects, ingredients, clinical studies and level of customer care. Furthermore, we took a look at dozens of user comments and dieter responses from all over the web. At this point, we condensed and summarized to give you with the facts you need.
What is Protandim?
First off, Protandim is a dietary supplement that is intended to reduce oxidative stress through “Nrf2 activation.” The ingredients used in Protandim are milk thistle extract, green tea extract, bacopa extract, turmeric extract and ashwagandha root.  According to the official website, this product can lower stress levels by 40 percent in only 30 days. This, in turn, helps the body function more efficiently, combats signs of aging and reduces damage from free radicals. You should take it with food. 
Protandim is made by LifeVantage, and it has been available since 2003. This supplement contains natural ingredients, and there is useful contact information on the company website. Furthermore, it’s easy to purchase through the main website, but read on…
Customer Complaints – “Concerning?”
The first thing we address with Protandim ingredients is the number of customer complaints. According to our Research Editor, “There are quite a few Protandim testimonials that are not exactly positive. This is a red flag that should not be ignored.”
One customer commented, “This product did nothing for me whatsoever! Don’t buy!”
“Waste of money! My doctor even told me to stop using it,” said another user.
Results with Protandim – “Lacking”
One doctor commented, “Their product is extremely overrated and they have NO positive human studies whatsoever. The components in Protandim can be acquired on Amazon for a tiny fraction of the cost of what it’s costing now.” 
Another person stated, “I do not recommended the use of Protandim. There is no evidence that it provides a health benefit to humans.”
Our research has proven that if there is some particular part of a weight-loss supplement or diet program that is especially burdensome (too many customer complaints, lack of results, high cost) the likelihood of long-term success is quite minimal. So, if Protandim does fail to produce measurable effects in a lot of people, this could be problematic. 
The Science – “Valid?”
Although “science” is mentioned for Protandim on the official website, there are no actual clinical trials involving humans, which makes it difficult to determine how well this product works. At DietSpotlight, we prefer to see documented research regarding the product and how well it works on .
The Bottom Line – Does Protandim Work?
Alright, are we out there looking for some Protandim, the same one Dr. Oz talks about. Well, we like that it contains natural ingredients and a lot of information is presented on the company website.  But we have some reservations because no solid science is provided that involves human clinical trials. Also, we’re concerned about the customer complaints and negative comments posted online.
If you’d like to drop more weight, then we encourage you to select a product that is supported by lots of positive user feedback, backed by solid clinical research and sells at a reasonable price.
Among the best products we’ve seen this year is one called Leptigen. Its formula is a proprietary blend of four powerful ingredients, which has been shown in documented scientific research to help accelerate fat loss and ignite metabolism. Also, we can’t find any complaints about harmful side effects and customer comments found online indicate people see great results.
The makers of Leptigen are so certain of their product they’re offering a Special Trial Offer, which is a good sign.
Previous Protandim Review (Updated April 9, 2014):
Protandim: What You Should KnowAt first glance, Protandim does not look like a diet product. The product description talks about reducing oxidative stress, or stress caused by free radicals. This means the supplement contains antioxidants, but there is one proven weight loss ingredient in the formula, so there is some good to be had out of taking this product with an exercise program and healthy meal plan. Pertaining to meal plans, meal supplements with protein, green coffee bean and other ingredients, can be found in Metagenics which can be conducive to healthy weight loss. The complete Protandim ingredient list is available on the official website and there is mention of clinical studies. This does not mean clinical studies have been completed directly on Protandim, but we'll see.
- Milk Thistle Extract
- Bacopa Extract
- Ashwagandha Root
- Green Tea Extract
- Turmeric Extract
Features of ProtandimThe two ingredients we are most interested in from a diet point of view are green tea and turmeric. Green tea is clinically proven to boost metabolism, even if the caffeine in green tea is taken out of the equation. The EGCG present in green tea boosts metabolism in addition to the added benefits of caffeine. In addition, you can find bacopa extract, which when combined with caffeine, bauhinia purpurea, germanium stem extract, Cirsium oligophyllum, and rauwolscine extract, bacopa extract may be able to increase weight-loss for young and fit men and women. Turmeric recently hit the weight loss market with some pretty impressive preliminary studies. In the studies, participants who took turmeric lost more weight than participants who did not. Additional large-scale studies replicating this effect are needed before the ingredient is considered clinically proven. Although weight loss is an indicator for change in health benefits, one should consider the growth of joint health, immune system support and nutrients infused with vitamins and minerals; Natures Balance is one for consideration. While researching the Protandim Ingredients, we found something odd. Under the clinical proof tab we found the clinical proof we'd hoped for, but the study has nothing to do with weight loss. Protandim is clinically proven to reduce oxidative stress. In other words, the supplement works as an antioxidant, which can impact overall health, but not weight loss directly. Similarly, Catalyst doesn't intentionally promote weight loss, but it does help muscle growth and recovery using amino acids, both conducive to health and wellness for the long-term.
Advantages of Taking Protandim
- Proven to have antioxidant effects on the body.
- May reduce oxidative stress by 40%.
- Clinical studies were completed on Protandim, not just the ingredients.
- Green tea and turmeric are proven to boost metabolism and weight loss.
Disadvantages of Taking Protandim
- Protandim is not a weight loss supplement.
- No detailed information on ingredient amounts.
- The only customer reviews available on the website are in video format.
ConclusionProtandim is quite an impressive supplement in its given category, but that category is not weight loss. While green tea and turmeric may be beneficial for weight loss, we have no idea how much of each ingredient is included in the supplement. The recall that turned up during our research also concern us. It is unlikely that there is enough of either to boost metabolism, as one of the Protandim benefits, since this supplement is created as an antioxidant not a fat burner. There should be no negative interactions between this supplement and other fat burners, but it is best to contact your physician before taking Protandim.
Protandim Questions & Answers:
We narrowed down hundreds of user reviews about Protandim and created this helpful FAQ.
What are the side effects of LifeAdvantage Protandim
Some potential Protandim side effects, reported by customers, include allergic reactions, vomiting, diarrhea, stomach ache, headache and rash .
What are the ingredients in Protandim?
Protandim ingredients include milk thistle , bacopa extract, ashwagandha, green tea and turmeric.
Does Protandim work?
There a several studies listed on the Protandim website. What we noticed after reviewing the research, were the findings didn’t relate to weight-loss, only oxidative stress. Although the supplement contains green tea, an ingredient linked to weight-management, it doesn’t point toward this formula.
You may want to take a closer look at Protandim, what you want out of a dietary supplement and thinking about a supplement like Leptigen, which consists of some clinically-tested ingredients.
How much does Protandim cost?
Protandim costs $50 for a 30-day supply. If you sign up for the auto-ship, the cost is $40.
How should I take Protandim?
You should take one Protandim capsule per day. One bottle lasts a month.
Can I take Protandim if I have a health condition?
Women who are pregnant or nursing, those with health conditions, anyone under 18 years of age or people taking prescription medications should contact a healthcare professional prior to using a dietary supplement of any kind, including Protandim.
What do users like about Protandim?
Some users liked the low price tag of Protandim.
What do users NOT like about Protandim?
Not losing weight was something Protandim users didn’t like.
How do I contact the Protandim customer service department?
You can connect with the Protandim customer service department by calling 1-866-460-7241, emailing a representative at email@example.com or by mailing correspondence to LifeVantage Corporation 9785 S. Monroe St. Suite 300 Sandy, UT 84070.
Can I contact Protandim through social media?
Does Protandim contain caffeine?
No, Protandim doesn’t contain caffeine, but the green tea could possibly act as a stimulant.
What is NrF2 in Protandim?
NrF2 in Protandim is a protein supposedly stimulating enzymes to reduce the effects of free radicals.
Why was Protandim pulled from the shelves?
Protandim was pulled from the shelves in 2012 because the company found some lots possibly includes metal fragments.
Does Protandim come with a guarantee?
Protandim does come with a guarantee. You have 30 days to return the supplement for a full refund.
Do you know of any special deals or discounts on Protandim?
There’s no mention of deals or discounts on the official Protandim website, you’ll have to ask Dr. Oz! However, our readers have been going wild over the last few months taking advantage of Leptigen’s Special Trial Offer, which is simply the cost of shipping and handling. Click above to give it a try.
Protandim Scientific Abstracts:
There was no evidence found regarding the carcinogenic activity of milk thistle within female or male rats given 12,500, 25,000, or 50,000 ppm. There were elevated incidences of clear and mixed cell foci within the liver of those exposed to milk thistle, as well as the reduction in body weight in female and male rats. Reductions in incidences of mammary gland neoplasms were noticed in female and male groups exposed to milk thistle, and there were decreased incidences of hepatocellular neoplasms within female and male groups exposed to milk thistle. 
Standardized Bacopa monnieri extract greatly decreased subtest scores of symptoms of ADHD, with the exception of social issues. Restlessness scores decreased in 93% and improvement in self-control was noticed in 89% of the children. AD (attention deficit) symptoms were decreased by 85%. Learning issues, impulsivity, and psychiatric issues were decreased as well for 78%, 67%, and 52% of the children. 74% of children showed up to a 20% decrease, while 26% displayed between 21% and 50% decrease in total subtests. In conclusion, standard extract of Bacopa monnieri was discovered to be beneficial in the alleviation of ADHD symptoms as well as being well tolerated by the children subjects. 
The group given ashwagandha showed a substantially greater elevation in muscle strength on the bench press than the placebo subjects (Placebo: 26.4 kg, 95 % confidence interval, 19.5, 33.3 versus Ashwagandha: 46.0 kg, 95 % confidence interval 36.6, 55.5; p = 0.001). They also experienced greater muscle strength on the leg-extension exercise (Placebo: 9.8 kg, 95 % confidence interval, 7.2,12.3 versus Ashwagandha: 14.5 kg, 95 % confidence interval, 10.8,18.2; p = 0.04) and substantially greater muscle size increase of the chest (Placebo: 1.4 cm, 95 % confidence interval, 0.8, 2.0 versus Ashwagandha: 3.3 cm, 95 % confidence interval, 2.6, 4.1; p < 0.001) and arms (Placebo: 5.3 cm2, 95 % confidence interval, 3.3,7.2 versus Ashwagandha: 8.6 cm2, 95 % confidence interval, 6.9,10.8; p = 0.01). In comparison to those taking placebo, the individuals taking ashwagandha had experienced more of a decrease of exercise-induced muscle damage which was discovered due to the stabilization of serum creatine kinase (Placebo: 1307.5 U/L, 95 % confidence interval, 1202.8, 1412.1, versus Ashwagandha: 1462.6 U/L, 95 % confidence interval, 1366.2, 1559.1; p = 0.03) substantially more testosterone (Placebo: 18.0 ng/dL, 95 % confidence interval, -15.8, 51.8 versus Ashwagandha: 96.2 ng/dL, 95 % confidence interval, 54.7, 137.5; p = 0.004) and a greater reduction in percentage of body fat (Placebo: 1.5 %, 95 % confidence interval, 0.4 %, 2.6 % versus Ashwagandha: 3.5 %, 95 % confidence interval, 2.0 %, 4.9 %; p = 0.03). In conclusion, the study suggests that ashwagandha supplementation is linked with substantial elevations in muscle mass and strength and indicates that ashwagandha supplementation could be beneficial along with a resistance training program. 
- 1. Toxicology and carcinogenesis studies of milk thistle extract (CAS No. 84604-20-6) in F344/N rats and B6C3F1 mice (Feed Studies) (2011). National Toxicology Program Technical Report Series. January 15, 2017.
- 2. An open-label study to elucidate the effects of standardized Bacopa monnieri extract in the management of symptoms of attention-deficit hyperactivity disorder in children (2014). Advances in Mind-Body Medicine. January 15, 2017.
- 3. Examining the effect of Withania somnifera supplementation on muscle strength and recovery: a randomized controlled trial (2015). Journal of the International Society of Sports Nutrition. January 15, 2017.
Protandim Side Effects:
Protandim is a widely-used product for health and weight-loss. While the weight-loss results are mixed, most experiences are free of negative consequences. However, there are some rare Protandim side effects to be aware of.
Stomach pain can make it hard to get through the day. In milder cases, it’s a general unease in your stomach area. When it becomes severe, stomach pain can be an acute stabbing sensation. Often, stomach pain is accompanied by symptoms like gas, bloating, nausea, fever, and sweating.
What causes stomach pain?
Stomach pain has many possible causes. Many cases stem from indigestion and food intolerance. It’s also possible to experience abdominal pain as a result of pelvic inflammatory disease or stomach virus. 
A bad case of the “the runs” can be extremely uncomfortable. Having to go to the bathroom every few minutes to pass a watery stool leaves you exhausted. Your rectum is prone to burning and rash. Also, because diarrhea expels so much liquid, you’re at risk of dehydration. If you suffer from diarrhea, be sure to drink plenty of fluids.
What causes diarrhea?
Most cases of diarrhea are the direct result of stomach viruses and bacteria. These infect your body when you eat something spoiled. It may also be that your body has an intolerance or allergy to something you ate. Or you may be suffering from irritable bowel syndrome.
Vomiting is often accompanied and preceded by nausea and stomach ache. It can consist of various sessions and come and go throughout the day. Vomiting leaves you with a burning sensation in your throat. It can also lead to dehydration and malnutrition. Prolonged vomiting is cause for concern and may require the attention of a doctor.
What causes vomiting?
One of the top causes of vomiting is food poisoning. Be careful with what you consume. Always make sure food isn’t expired and that it doesn’t contain ingredients to which you’re allergic. Vomiting can also be a result of conditions like migraine, appendicitis, concussion, hyperthyroidism, and fever. 
A headache can be very stressful. Depending on the severity of the pain, you may feel dizzy and weak. Headaches make it hard to focus and concentrate.
What causes headaches?
Most headaches are not cause for concern. They’re provoked by stress, hunger, or tiredness. They go away after a few hours with rest. Some headaches may be indicative of an underlying illness. Glauccoma, high blood pressure, and stroke are known to cause headaches. Seek a doctor’s help if you experience regular headaches.
Protandim is normally safe to use. Everyone reacts differently to supplements. To be on the safe side, talk with your doctor about how Protandim’s ingredients may influence your health.
We’ve heard the rumblings about Protandim dietary supplement, so we decided to learn more about the supplement by concentrating on Protandim side effects. We paid close attention to the ingredients and clinical research. We also analyzed consumer comments. We then summarize the info to give you the bottom line.
What You Need to Know
Protandim is a dietary supplement with green tea extract, ashwagandha, bacopa, caffeine and milk thistle. The recommended serving is one capsule per day to promote weight loss, according to the official website. The pill bottle is small enough to take on the go.
The product, introduced in 2004, doesn’t appear to contain synthetic ingredients, a good choice. You can purchase Protandim on the official website and through distributors. We do like that we found some positive customer comments and that the company has been in business for more than 10 years, but read on…
The first issue with Protandim side effects is headaches. “Dieters try out supplements because they claim to make you feel better or promote overall health,” said our Research Editor. “Why would they pay money to be in pain?”
“I have been taking it for 4 days and have started to have some side effects, achy, headache, swollen throat, nausea and some dizziness,” commented a user.
“I took Protandim for 3 days, and got a horrible headache. I never get headaches. I stopped taking it, and the headache went away,” reported a dieter.
In December of 2012, LifeAdvantage announced a voluntary recall of Protandim due to contamination. Small metal fragments were found in several lots.
Based on customer comments, Protandim side effects also include stomach issues. “Everyone has had some kind of sickness while taking Protandim like a common cold or the flu,” commented one distributor.
“Ever since I started taking Protandim I’ve been feeling sick, I don’t think it’s helping,” said a dieter.
“I started taking Protandim by a recommendation from a retail sales rep. Within hours I had diarrhea like you can’t believe. Took another Protandim and WAMMO! Diarrhea like before,” reports a user.
According to our research, any part of a supplement thought of as a concern, such as side effects, could put a damper on long-term success. If Protandim causes adverse reactions, there’s a problem.
According to the Protandim website, the supplement is “clinically proven”, but the studies listed don’t necessarily link the formula to weight-loss. As a matter of fact, most were completed on mice and the one on humans related to alcohol abuse. Many of the research links talk about antioxidants, not Protandim. At DietSpotlight, science is the key to our support. If there’s none to speak of there’s no need to back the product.
The Bottom Line
After an exhaustive look into LifeAdvantage Protandim, we’ve come to a verdict. We like that the company has been in business for several years and we located some favorable customer comments, but we can’t recommend it because the research provided is not about weight-loss. Plus, we’re concerned that the stomach issues and headaches are not exactly what the dieter ordered.
If you’d like to lose weight, we recommend a supplement supported by published clinical research with no reported side effects.
Leptigen is among the best supplements we’ve encountered in 2016. The product consists of a formula as a four-ingredient proprietary blend, which has been shown in published scientific research to help increase metabolism and ignite fat loss. We couldn’t locate any one commenting about negative side effects and reviews on the web show people are noticing excellent results.
Additionally, the company that makes Leptigen is providing a Special Trial Offer because they are confident in the formula.
Protandim is a supplement that claims to have antioxidants, that can aid in weight loss.
Protandim Ingredients and Supplement Facts
Serving Per Container: 30
|Amount per Serving||% DV|
Other Ingredients: None
We dug deep into the Protandim ingredients to give you the important specifics you need. You can review Protandim testimonials to learn more how users felt while on the product.
Milk Thistle Extract
Also called silybum marianum, this is an herb that has been used in traditional remedies for centuries. It’s sometimes used to treat mushroom poisoning, liver disease, viral hepatitis, and even cancer.
What is it Supposed to Do?
Milk thistle contains antioxidants that help ward off free radicals and reduce inflammation. It’s often used in cleansing supplements to help flush dangerous toxins and impurities out of the body.
There is really not much solid research that supports the claims pertaining to milk thistle. However, according to the Mayo Clinic, “Medical research does suggest that milk thistle, combined with traditional treatment, can improve diabetes. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in people with type 2 diabetes.” 
Clinical testing is important when it comes to choosing the best diet supplement for your needs and fitness goals. You may want to take a look at a formula like Leptigen. This product contains key ingredients that have been scientifically researched.
Also referred to as bacopa monniera, this is a plant that is often used in Ayurvedic medicine. It has been claimed to treat epilepsy, asthma, irritable bowel syndrome, anxiety, joint pains, body aches and Alzheimer’s.
What is it Supposed to Do?
You will find that bacopa extract is used in many diet supplements. It’s typically claimed to improve memory and focus, while boosting sexual performance. However, there does not appear to be a direct link to weight-loss.
According to PubMed.gov, “There is some evidence to suggest that Bacopa improves memory free recall with evidence for enhancement in other cognitive abilities currently lacking.”
The berries and roots of the ashwagandha plant are often used to make medicine. More specifically, this herb has been used to treat arthritis, anxiety, diabetes, high cholesterol levels, ADHD, liver problems and stress. It’s also found in some over-the-counter supplements.
What is it Supposed to Do?
Often ashwagandha root is claimed to reduce stress levels, which in turn lowers cortisol, the hormone that leads to weight gain and belly fat. It contains lactones and antioxidant steroidal alkaloids. This herb may also help lower blood sugar levels.
Some research has been conducted with ashwagandha root. For instance, WebMD states, “There’s some early evidence that ashwagandha affects the immune system and helps reduce swelling, from both arthritis and fluid retention. However, the practical benefits and risks for people aren’t clear yet.”
Is There Anything Out There That We Think TRULY Works?
There is one supplement that caught our eye. Leptigen, which is formulated with clinically tested ingredients, comes across as a solid option. Each and every customer can take complete advantage of a Special Trial Offer, that’s currently available. Click here to give it a try today.
We often come across a supplement like Protandim that needs a little closer attention. This time around we looked hard at Protandim ingredients. We checked out the side effects and clinical support for the formula. Reading through hundreds of consumer comments was also a part of the process. Then, we refined the information to give you the bottom line.
What You Need to Know
First off, Protandim is a supplement that claims to promote antioxidant production with milk thistle, ashwagandha, bacopa, green tea and turmeric. There are 30 caplets in each bottle, so we suspect you take just one a day. This is supposed to support overall health and, in some dieter’s minds, spark weight-loss. You don’t have to worry about lugging around the bottle if you take it at home.
The supplement, offered up by LifeVantage sometime after 2009, does not use synthetic ingredients, impressive. We found it for sale on the official website and outside retail sites. It’s good that there are some clinical studies and a few positive reviews, but read on…
Is There Clinical Support?
Our first issue with Protandim ingredient is the utter lack of clinical support. There have been research studies completed on the formula, but more than 90% have been on animals or in the lab. We even found one that claimed it DIDN’T work. We checked the official website and didn’t find any mention of proof this supplement is better than others that support antioxidant production.
FDA – Voluntary Recall
In 2012, LifeVantage, the makers of Protandim, recalled the supplement because it could have contained metal fragments. The issue was resolved and new lots were released back onto the market.
One of the biggest issues with dieters doesn’t have anything to do with Protandim ingredients. The MLM method of selling the line is not lost on the consumer. “By now, you should know that snakeoil products sold through MLMs like LifeVantage are scandalously overpriced, useless, and unworthy of consideration by consumers,” says a user.
Another claims, “In a nutshell, distributors are being armed with a bottle of scandalously overpriced capsules and told that they should try to get rich by telling consumers (friends and family typically) that the product will cure whatever ails them.”
One dieter explains how to get the same results for less, “Even at standard retail prices for the ingredients, it would be possible to recreate Protandim exactly at about 1/15 to 1/20 the price that it retails for.”
There is no science linking Protandim to weight-loss. Not a single study we came in contact with even broached the subject. At DietSpotlight, it’s the research that saves the day. Without that, the dieter may as well move on.
The Bottom Line
Protandim ingredients offered a good read and the information we found made it easy to come to a conclusion. We like that the formula is described online and that several clinical studies have been performed on the supplement, but we can’t recommend a product that simply doesn’t win out over the competition. Plus, we’re concerned about the recall in 2012.
If you have that push to lose weight, we suggest trying out a product that offers a list of proven ingredients that don’t cause side effects.
Among the finest supplements we’ve researched in 2016 is Leptigen. We found a four-ingredient proprietary blend with published clinical research showing it helps spark metabolism and boost fat loss. There are no reports of adverse side effects and dieters are sharing the fact that they’re seeing great results.
Also, Leptigen makers are confident in the formula so they’re offering a Special Trial Offer.
- 1. Milk thistle (Silybum Marianum) (2013). Mayo Clinic. November 1, 2016.
- 2. An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda (2011). African Journal of Traditional, Complementary and Alternative Medicines (AJTCAM). November 1, 2016.