Updated: 01/14/2018

There’s been some buzz around Protandim Nrf2 – what’s the deal? We found out by taking a closer look at the ingredients, side effects and clinical research. Furthermore, we took into account hundreds of user experiences. Then, we compiled the details to give you the facts you need.

Protandim Readers: Click here to find out why we're giving away samples of our product, Burn HD.

What is Protandim?

First off, Protandim is two different health supplements: Protandim Nrf1 Synergizer (released first) and Protandim Nrf2 Synergizer. Together, these products aim to boost cognitive performance and brain health, as well as reduce oxidative stress that contributes to aging.


We all experience cellular stress through the process of living (eating, sleeping, breathing and exercising) and Protandim aims to slow this down.

Both are available over-the-counter but help in different ways. Here is a better look at what each supplement contains:

Protandim Nrf1 Synergizer (original breakthrough formula)

  • Rhodiola rosea root
  • Alpha lipoic acid
  • Coenzyme Q10
  • Quercetin
  • Grape stem and fruit extract

Protandim Nrf2 Synergizer (new breakthrough formula)

Does Protandim contain caffeine?

Yes, Protandim contains 1.8 mg of caffeine per tablet.

Also, each Protandim supplement is 100% vegetarian and free of allergens such as dairy, wheat, gluten, yeast and gelatin. This makes it easier for people with allergies to use these products safely.

Products Similar to Protandim

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Burn HD (Sample offer)read

Protandim Benefits

Now for a closer look at the actual benefits of LifeVantage Protandim. Each supplement has different things to offer and the official website does a good job of elaborating on the effects of these formulas.

Protandim Nrf1 Synergizer Benefits

  • Increased mitochondria production
  • Improve performance through energy production
  • Enhance cellular health – cells function at peak performance
  • Reduced cellular aging
  • Promotes better sleep quality and promotes cellular repair
  • Increase cellular energy  (ATP)
  • Slow cellular energy by supporting chromosome integrity

WARNING: Not for use by individuals under the age of 18.

Instructions: Take two tablets with food and a glass of water in the morning.

Protandim Nrf2 Synergizer Benefits

  • Help body detoxify genes, keeping the master blueprint of the cell’s function intact
  • Help body repair and rejuvenate its own cells
  • Reduces cellular stress (through Nrf2 activation)
  • Produces enzymes that combat harmful free radicals
  • Regulates survival genes
  • Lowers oxidative stress by 40% in only 30 days

Instructions: One tablet daily with food (for adults)

We were able to find some solid studies that support the product and its effects on oxidative stress. One study said: “Protandim, a combination of five herbal ingredients, potently induces antioxidants in oligodendrocytes and is able to protect oligodendrocytes against oxidative stress by preventing ROS-induced cell death and promoting OPC differentiation.” [cte url=https://www.ncbi.nlm.nih.gov/m/pubmed/27618111/?i=2&from=Protandim]

Another study showed that, when combined with 6-gingerol, it can help preserve cartridge, and in turn protect the body against osteoarthritis. [1]

Dual Synergizer Benefits

  • Turn on natural antioxidant production
  • Repair and rejuvenate cells
  • Protect cells from free radical damage
  • Promotes cellular repair
  • Boost cellular health
  • Support chromosome maintenance
  • Improve sleep quality
Protandim Customer Testimonials

About LifeVantage

LifeVantage Corporation is the multi-level marketing (MLM) company behind Protandim products. This company has been in business since at least 2003 and has a solid A- rating with the Better Business Bureau.

Image result for lifevantage

The scientist behind this supplement is Dr Joe McCord. He was once a Chief Scientific Officer. According to the company website, Protandim appeared on Primetime in 2005. [2]

Back then it was sold in retail stores but is now available more exclusively through authorized dealers. Here is the corporate contact info that’s presented on the official website:

LifeVantage Corporation
9785 S Monroe St Ste 300
Sandy, UT 84070-4292
Phone: 1 (866) 460-7241

LifeVantage Company Chart

Type: Public

Industry: Multi-level marketing (MLM) company

Founded: 2003

Headquarters: Salt Lake City, Utah, United States

Areas served: United States, Japan, Canada,  Mexico, Australia, Hong Kong

Key people:

Image result for Darren Jensen

  • Darren Jensen – President & CEO
  • Robert M. Urban – COO
  • Mark Jaggi – CFO
  • Joe M. McCord Chief Science Officer (retired)

Products: Dietary supplements, skin care

Revenue Increase: US$ 208.2 million (2013)

Operating income: US$ 12.1 million

Website: www.lifevantage.com [3]

Other products offered by this brand include supplements for beauty, fitness, pets, and other nutritionals, some of which are as follows:

  • AXIO (regular and decaf)
  • LifeVantage Omega+
  • Petandim x3

PhysIQ products

  • Probio
  • Fat Burn
  • Cleanse
  • Curb
  • Protein Shake

Also, we did notice that the FDA sent a warning letter to LifeVantage regarding marketing Protandim Nrf2 Synergizer as a drug. This is due to the benefits that the official website claims it has. Since the FDA warning, it appears that Protandim has reworded the benefits for these LifeVantage products so they are not mistakenly seen as drugs or medical treatments. [4]

Beyond the warning letter, Protandim statements have not been evaluated by the Food & Drug Administration (FDA).

Image result for protandim


Protandim Research

There is some science presented on the official website that supports Protandim results. The science offered to support Protandim Nrf1 Synergizer focuses on how the supplement reduces oxidative stress, increases ATP, boosts mitochondria production and activates the Nrf1 protein to slow down cellular aging, elevate cellular energy, boost brain health and improve cognitive performance.

As for Protandim Nrf2 Synergizer, there were actual studies conducted that show that this health supplement can activate the Nrf2 protein, provide protective antioxidant enzymes, and reduce oxidative stress levels by up to 40% in only 30 days. What’s more, this formula elevates glutathione by 300%, superoxide dismutase by 30% and catalase by 54%. [5]

Also, there is substantial research that supports the antioxidant ingredients in this supplement. These ingredients include grape stem/fruit, quercetin, coenzyme q10, alpha lipoic acid, green tea and milk thistle. Studies have shown that antioxidants not only combat harmful free radicals that lead to signs of aging and damage to the body, but they also reduce inflammation, which is a key cause of disease, health problems and aging. [6]

Protandim vs Cancer?

There is even some research on Protandim and cancer. As you may already know, oxidative stress and free radical damage have been linked to the development of cancer. Therefore the key is to lower stress levels and reduce free radical damage to cells. The PLOS One Journal reports that this antioxidant enzyme therapy may be a potent approach to the prevention of cancer. While this study was conducted on mice, there are more studies being done to see how this product impacts humans. [7]

Protandim Ingredients

Let’s hone in on the individual ingredients for the product to gain a better understanding of how these health supplements work.


An important mineral found in foods such as kale, milk, almonds, cheese, broccoli and tofu. It’s crucial for healthy teeth and bones and is important for heart and nerve function. [8]

Turmeric extract

A plant that commonly grows in India, South America and some other parts of Asia. It’s often used as a food spice and is related to the ginger plant. Some people take this herb as an alternative treatment for gallbladder problems, arthritis, cancer, inflammation and stomach issues. [10]

Also, turmeric has been approved in some countries to treat digestive problems such as gas and bloating. [11]

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Milk thistle seed

Also called holy thistle, this is a herb that contains a flavonoid called Silymarin, which has anti-inflammatory and antioxidant effects. It has been used to treat conditions such as gallbladder disorders, type 2 diabetes, jaundice, liver problems and hepatitis. [12]

Ashwagandha root

Sometimes called withania somnifera, or Indian ginseng, this root is often used in Ayurvedic medicine to treat a variety of health conditions and has been shown to lower cholesterol levels, reduce anxiety, and even help regulate blood sugar. [14]

Bacopa monnieri herb

A herb that is often used in over-the-counter nootropic supplements for boosting cognitive function, improving memory, reducing anxiety and elevating mental performance. [16] [16]

Green tea leaf

Also called camellia sinensis, this plant contains both caffeine and EGCG (catechins). It’s consumed as a beverage and has been tied to health benefits such as cancer prevention, weight loss, lower cholesterol levels, higher energy and reduced blood pressure. [17]

A Molecular Nutrition and Food Research study reveals that green tea may have both anti-diabetic and anti-obesity effects. This is mainly due to the epigallocatechin gallate (EGCG) found in this herb. [18] Image result for Rhodiola rosea root

Rhodiola rosea root

A Scandinavian herb that is often used in traditional Chinese medicine. It’s typically claimed to boost cognitive function, promote longevity and reduce mental fatigue. This substance is found in many over-the-counter nootropics.[19] [20]


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Alpha lipoic acid

A potent antioxidant found in foods like potatoes, broccoli, tomatoes, spinach, yams, and yeast. It is said to boost the health of the immune system, improve blood sugar levels, aid with weight loss and protect the body from harmful free radicals. [21] [22]

Coenzyme Q10

An antioxidant found in plants, animals and people. It’s important for proper cell function and producing energy for the body, and is sometimes used to treat heart conditions like hypertension, and may help combat signs of aging and treat muscle weakness and other health problems. [23] [24]


A plant polyphenol and bioflavonoid that may help prevent cancer, protect the heart, treat hypertension, lower blood pressure and reduce harmful inflammation. It’s found in various grains, fruits and vegetables, and is often added to manufactured beverages, supplements and food products. [25][26]

Grape stem and fruit extract

This fruit and stem extract provides antioxidants (bioactive polyphenols) to help ward off free radicals and reduce oxidative stress. Some research has shown that this ingredient helps reduce sun damage and inflammation. [27] [28]

Protandim Side Effects

As with any dietary supplement or health product, it may cause some mild side effects. After looking at all sorts of LifeVantage reviews posted online, here are the effects you may notice while taking this product:

  • Nausea
  • Upset stomach
  • Digestive issues
  • Headaches

According to WebMD, ashwagandha can cause diarrhoea, upset stomach and vomiting. [29]

Image result for upset stomach

It also states that bacopa monnieri can potentially lead to fatigue, increased bowel movements, dry mouth, cramps and nausea. [30]

Also, it is specified on the official website that Protandim is not for individuals under the age of 18, nor is it for women who are pregnant or nursing a child. If you are on immunosuppressive therapy, you need to speak with your doctor before taking Protandim Nrf2 Synergizer caplets.

How to Take LifeVantage Protandim

The directions on the bottle’s label say to take two capsules of Protandim Nrf1 Synergizer with a glass of water and food each morning.


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As for Protandim Nrf2 Synergizer, the instructions say to take one caplet each day with food. There is no mention of a specific lifestyle change with these products. Therefore it does not expect you to exercise regularly or adhere to a special diet plan. However, adopting a healthy diet and exercise program will certainly improve your overall wellness and you will likely see even better results with Protandim.

Note that you can take Protandim supplements together if you choose. In fact, it’s fine to stack Protandim tablets with other LifeVantage products. These include Omega+ (supports brain, cardiovascular, skin and immune system health) and PhysIQ Probio (supports healthy immune system and optimizes digestion).

Where to Buy Protandim

At this point, you’re probably wondering where you can buy Protandim. Well, according to the official website, you can only find Protandim for sale through their distributor network. If you go to the main website, it will ask you to search for a distributor by name or distributor ID.

On the other hand, we did find LifeVantage Protandim on Amazon. [31].

Therefore, some authorized distributors must be selling the supplements through this dealer website. Unfortunately, common retail stores and health supplement shops no longer sell this product.

Protandim Price

What about Protandim’s cost? The prices for Protandim Nrf1 Synergizer capsules and Protandim Nrf2 Synergizer caplets are not actually on the main website. This means that the cost of these supplements may change from distributor to distributor.

As for Protandim’s Amazon prices, Nrf1 Synergizer sells for $59.95 with free shipping, and the Nrf2 Synergizer goes for $55 plus $4.79 for shipping. In other words, both products are around $60 per bottle for a 30-day supply. You can also buy these supplements together on Amazon for $114.95.

As for a return policy, LifeVantage offers a 100% 30-day refund guarantee. However, you must not have opened the product in order to qualify for a refund.

Protandim Alternatives

It’s no big secret that oxidative stress on the body and brain can lead to free radical damage. This is where antioxidants come into the picture, including plant polyphenols, vitamins, minerals, enzymes, flavonoids and herbal components. Antioxidants neutralize the damage caused by free radicals and oxidative stress. This, in turn, can improve overall health, prevent illness and disease, and fight common signs of aging. [32]

People generally get antioxidants from their diet, which includes foods such as vegetables, whole grains, fruits, beans, seeds, nut, legumes, and sprouts. [33]

This helps with combating daily stressors and free radical damage caused by lifestyle choices, pollution, diet and work. It’s common to obtain some antioxidants through supplements as well. This is where Protandim fits into the picture. It provides herbal ingredients that offer protection from oxidative stress. Some research has shown that antioxidant supplements can be helpful when it comes to reducing oxidative stress that can lead to health problems such as high blood pressure or hypertension. [34]

Here is a closer look at some alternatives to Protandim. These supplements are all available over-the-counter and you can find them through online dealers.

  • Pure Therapeutics Nrf2 Boost
  • AMRAP Nutrition Super Berries
  • VitaRave
  • Sundown Naturals Stress Formula
  • Stresstabs
  • HUM Nutrition Big Chill

Protandim vs Thrive

First off, Thrive is a series of products that focus on weight management, whereas Protandim does not claim to help in that field. Protandim is marketed as a “nootropic and stress relief supplement” and doesn’t even demand a special diet or an exercise routine when you are on it.

Thrive, on the other hand, promises “premium support and benefits in the areas of weight management, cognitive performance, digestive & immune support, healthy joint function, lean muscle support, general discomfort, and age-defying & antioxidant support.”

Note that their official website talks about weight management, and not weight loss. Therefore, Thrive aims to be a “lifestyle enhancer”, like Protandim, but its focus is on anti-aging and reducing stress levels.

Most important, however, is the fact that there are clinical trials and research to support the effectiveness of Protandim and what it claims to be able to do. Thrive products, on the other hand, have no clinical trials, extensive research, or any kind of concrete science to support its claims.

Protandim vs Plexus

Plexus products, much like the Thrive line, focus on weight management rather than anti-aging and stress management like Protandim does.

The Plexus website has this to say about one of their most popular products, Plexus Slim: “Slim features a premium microbiome activating formula that contains ingredients clinically demonstrated to improve your gut health and promote weight loss! Slim is a no-brainer. Feed your gut beneficial prebiotics, support a healthy glucose metabolism, and lose weight – all with one great-tasting pink drink.”

However, again like Thrive products, there is scarce scientific evidence that the cocktail of ingredients in Plexus products actually does lead to effective weight management, despite the fact that some people did record losing and maintaining weight while on Plexus.

Protandim vs Juice Plus

Juice Plus is a series of dietary powder shakes and bars that contain concentrated fruit and vegetable juices that have added vitamins and nutrients. Some of these include calcium, vitamins C and E, carotenoids, soluble fiber (glucomannan), enzymes, dried probiotics (lactobacillus acidophilus), and folic acid.

Studies that looked into how effective Juice Plus products are at increasing nutrients in the human body have reached mixed conclusions. It appeared to increase some (beta-carotene, vitamin C, vitamin E and folate), but, since they were added artificially, it’s not clear if Juice Plus is actually more effective than other, cheaper products that contain similar amounts of vitamins and nutrients.[35]

Studies on the effects that Juice Plus supplements have on reducing oxidative stress and DNA damage, which is far closer to Protandim’s ballpark, have also been mixed.[36][37][38][39]

All in all, Protandim does not have a special focus on weight loss or management, so you might want to seek one of these other products if that’s what you’re after.

However, it seems that Protandim is backed by more solid science than any of the other three products we’ve compared it to here. So, if you’re looking to reduce your cellular stress levels and have an anti-aging focus, it’s best to go with what Protandim has to offer.

What Users Are Saying

“”There is a definitely change in my energy levels after taking this product. Honestly, not exactly sure what it’s doing, but I know it works! I feel amazing thanks to these wonderful little pills. And I don’t care how that sounds.””

“”liked this product, but I think the price is just too much for me. I ordered it for my 15 year old spitz and we really saw a big difference in her running and jumping. Big its just too much for the small amount.””

“”Had lab work done before starting and after 45 days. No statistical significant changes in any of the test, including weight and body fat. I did not notice any change in how i felt physically or mentally. I am not saying it does not work just that I found no way to confirm that it does. Be nice if there was a large independent human study to support claims.””

Also: read our Burn HD Weight-Loss Kit review »Protandim Ingredients

The Bottom Line on Protandim

We must admit that Protandim has quite a bit to offer in regards to clinically backed ingredients and overall health benefits. We even found encouraging scientific research and numerous positive customer comments around the web. This says a lot about this health supplement. On the downside, here are a few concerns we have about Protandim:

  • This product is not available in stores and you must buy Protandim from an authorized dealer.
  • There was an FDA warning letter regarding the medical claims on the official website for Protandim Nrf2 Synergizer, but it looks like they corrected this issue.
  • These health supplements do not help with fat loss or weight management.
  • If you’re striving to reduce damage from stress, improve health, boost energy and enhance cognitive performance, consider pairing Protandim with a supplement that contains a clinically-tested ingredient combo shown to spark energy levels and promote a healthy weight.

One health product that really stood out for us is Burn HD. It’s a completely natural supplement containing ingredients shown to increase energy, improve fat loss and support a healthy metabolism. But don’t take our word for it; just look at the positive user comments posted online that indicate great results.

Moreover, the company that makes Burn HD is so excited about this product, they’re giving away a 2-Week Sample to help you get started reaching your health and weight loss goals. A no-nonsense satisfaction guarantee even backs it, so there’s nothing to worry about.

Learn More About Burn HD »
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What are the side effects of Lifevantage Protandim?

Some potential Protandim side effects we’re mild, especially if they didn’t follow the directions.

What are the ingredients in Protandim?

Protandim ingredients include milk thistle , bacopa extract, ashwagandha, green tea and turmeric.

How do I know if Protandim is right for me?

Choosing the right product is the #1 question asked by DietSpotlight readers. We recommend trying any product before buying it and know that finding a product with a sample offer is near impossible - so we created our own product, Burn HD, with scientifically backed ingredients.

Click here to get your sample of our powerful fat burner today.

Does Protandim work?

There a several studies listed on the Protandim website. We noticed several dealt with oxidative stress, as well as the antioxidant effect of Protandim ingredients . Based on research and customer testimonials, there’s a chance you’ll see results.

How much does Protandim cost?

Protandim costs $50 for a 30-day supply. If you sign up for the auto-ship, the cost is $40.

How should I take Protandim?

You should take one Protandim capsule per day. One bottle lasts a month.

Can I take Protandim if I have a health condition?

Women who are pregnant or nursing, those with health conditions, anyone under 18 years of age or people taking prescription medications should contact a healthcare professional prior to using a dietary supplement of any kind.

Does Protandim contain caffeine?

No, Protandim doesn’t contain caffeine, but the green tea could possibly act as a stimulant.

What is NrF2 in Protandim?

NrF2 in Protandim is a protein supposedly stimulating enzymes to reduce the effects of free radicals.

Does Protandim come with a guarantee?

Protandim does come with a guarantee. You have 30 days to return the supplement for a full refund.

What is Protandim?

LifeVantage’s Protandim contains a patented herb blend that reduces oxidative stress. Supplementation of Protandim was studied in two small human trials.

What are the side effects from taking Protandim?

Some people experience allergic reactions to Protandim. These include gastrointestinal disturbances such as diarrhea, stomach upset and vomiting, as well as headaches, and a rash on the hands or feet may appear. These symptoms go away upon discontinuing the supplementation.

What is Protandim NRF1?

A breakthrough in nutrigenomics, Protandim NRF1 Synergizer helps you with the aging process by harnessing the power of mitochondria – the energy of youth.

How do you take Protandim?

Protandim NRF1 should be taken on an empty stomach with a full glass of water. After half an hour, Protandim NRF2 may be taken with food. Each dose is two capsules.

What are the five ingredients in Protandim?

Ashwagandha (Withania somnifera) root (150 mg)

How much caffeine is in Protandim?

There are 1.8 milligrams of caffeine per capsule. In comparison, a “caffeine-free” coffee typically contains between 4-7 milligrams and a Starbucks coffee can contain up to 150 milligrams.

Is Protandim gluten free?

The 100 percent vegetarian Protandim NRF2 Synergizer is free of dairy, gelatin, gluten, wheat and yeast. Milk thistle’s botanical name is Silybum marianum, which is a plant that is often used in Chinese medicine. It does not actually contain any dairy.

Protandim Ingredients

Protandim is a supplement using nutrigenomics to activate the Nrf2 pathway.

Protandim Ingredients and Supplement Facts

Serving Size: 1 Caplet
Serving Per Container: 30
Amount per Serving% DV
Milk thistle225mg*
Green tea75mg*

Other Ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Modified Cellulose, Stearic Acid, Magnesium Stearate, Maltodextrin, Medium Chain Triglycerides

We often come across a supplement like Protandim that needs a little closer attention. This time around we looked hard at Protandim ingredients. Additionally, we checked to see if there’s an issue with side effects and research supporting the formula. We also took into account what hundreds of users had to say. Then, we compiled the facts to give you the details you need.

What are Protandim Ingredients?

First off, Protandim ingredients are milk thistle, ashwagandha, bacopa, green tea and turmeric. The supplement reduces oxidative stress; the imbalance between the bodies ability to counteract the effects of free radicals and their production. You’ll take just one capsule per day.

The supplement, made by LifeVantage, does not use synthetic ingredients, impressive. The official website and outside retail sites sell the supplement. It’s good that there are clinical studies and a few positive reviews, but read on…

Clinical Support – “More Than One Study”

Our first thing tacked was the research supporting Protandim ingredients. “When it comes to a supplement, customers deserve the facts,” said our Research Editor. “With this one, we found more than enough solid science supporting it.”

According to Molecular Aspects of Medicine, “Pathway analysis of results shows significant modulation by Protandim of pathways.” [1]

Another study published in the Journal of Dietary Supplements found that “Protandim…was safe and well tolerated. A 48% average decrease in plasma TBARS (thiobarbituric acid-reactive substances) was seen.” [2]

Other Ingredients – “Offering More Support?”

Protandim nrf2 Synergizer is what we hear the most about, but what about the other ingredients. The supplement also includes milk thistle [3], bacopa [4], ashwagandha [5], green tea [6] and turmeric [7].

With each ingredient, you’ll notice it offers antioxidant support or boosts in metabolic rate.

So what do customers have to say about Protandim ingredients?

“I like the results I am having with these,” commented a user.

“I have extremely bad anxiety and a high stress level and this Protandim has helped both those issues,” stated a customer.

“Protandim NRF2 for about 9 months, and NRF1 for about 5 months now…could not believe the result,” offered another.

The Science – “Studies Backing the Claims”

Science is what Protandim does best. The company provides a section dedicated to Protandim ingredients. Unlike some companies that tell you that there’s research backing a formula; the company offers evidence. Studies go into depth about the benefits of supplement [8], the nrf2 protein [9] and its benefits toward oxidative stress [10], as well as its antioxidant properties [11].

The Bottom Line – Does Protandim Ingredients Work?

Protandim ingredients offered a good read and the information we found made it easy to come to a conclusion. We like that the formula is described online and that several clinical studies have been performed on the supplement. With the research alone, we feel we can stand behind this one.

If you have that push to lose weight, we suggest trying out a product that offers a list of proven ingredients that don’t cause side effects.

Among the best products we’ve seen this year is our product called Dietspotlight Burn. It contains a four-ingredient proprietary blend. All clinically-tested, with results often found in publications such as The American Journal of Clinical Nutrition.

Also, we’re offering customers a Special Trial Offer, which is a good sign you’ll love our supplement.

Protandim Scientific Abstracts

Milk Thistle

There was no evidence found regarding the carcinogenic activity of milk thistle within female or male rats given 12,500, 25,000, or 50,000 ppm. There were elevated incidences of clear and mixed cell foci within the liver of those exposed to milk thistle, as well as the reduction in body weight in female and male rats. Reductions in incidences of mammary gland neoplasms were noticed in female and male groups exposed to milk thistle, and there were decreased incidences of hepatocellular neoplasms within female and male groups exposed to milk thistle. [1]


Standardized Bacopa monnieri extract greatly decreased subtest scores of symptoms of ADHD, with the exception of social issues. Restlessness scores decreased in 93% and improvement in self-control was noticed in 89% of the children. AD (attention deficit) symptoms were decreased by 85%. Learning issues, impulsivity, and psychiatric issues were decreased as well for 78%, 67%, and 52% of the children. 74% of children showed up to a 20% decrease, while 26% displayed between 21% and 50% decrease in total subtests. In conclusion, standard extract of Bacopa monnieri was discovered to be beneficial in the alleviation of ADHD symptoms as well as being well tolerated by the children subjects. [2]


The group given ashwagandha showed a substantially greater elevation in muscle strength on the bench press than the placebo subjects (Placebo: 26.4 kg, 95 % confidence interval, 19.5, 33.3 versus Ashwagandha: 46.0 kg, 95 % confidence interval 36.6, 55.5; p = 0.001). They also experienced greater muscle strength on the leg-extension exercise (Placebo: 9.8 kg, 95 % confidence interval, 7.2,12.3 versus Ashwagandha: 14.5 kg, 95 % confidence interval, 10.8,18.2; p = 0.04) and substantially greater muscle size increase of the chest (Placebo: 1.4 cm, 95 % confidence interval, 0.8, 2.0 versus Ashwagandha: 3.3 cm, 95 % confidence interval, 2.6, 4.1; p < 0.001) and arms (Placebo: 5.3 cm2, 95 % confidence interval, 3.3,7.2 versus Ashwagandha: 8.6 cm2, 95 % confidence interval, 6.9,10.8; p = 0.01). In comparison to those taking placebo, the individuals taking ashwagandha had experienced more of a decrease of exercise-induced muscle damage which was discovered due to the stabilization of serum creatine kinase (Placebo: 1307.5 U/L, 95 % confidence interval, 1202.8, 1412.1, versus Ashwagandha: 1462.6 U/L, 95 % confidence interval, 1366.2, 1559.1; p = 0.03) substantially more testosterone (Placebo: 18.0 ng/dL, 95 % confidence interval, -15.8, 51.8 versus Ashwagandha: 96.2 ng/dL, 95 % confidence interval, 54.7, 137.5; p = 0.004) and a greater reduction in percentage of body fat (Placebo: 1.5 %, 95 % confidence interval, 0.4 %, 2.6 % versus Ashwagandha: 3.5 %, 95 % confidence interval, 2.0 %, 4.9 %; p = 0.03). In conclusion, the study suggests that ashwagandha supplementation is linked with substantial elevations in muscle mass and strength and indicates that ashwagandha supplementation could be beneficial along with a resistance training program. [3]


Previous Protandim Review (Updated April 9, 2014):

Protandim: What You Should Know

At first glance, Protandim does not look like a diet product. The product description talks about reducing oxidative stress, or stress caused by free radicals. This means the supplement contains antioxidants, but there is one proven weight loss ingredient in the formula, so there is some good to be had out of taking this product with an exercise program and healthy meal plan. Pertaining to meal plans, meal supplements with protein, green coffee bean and other ingredients, can be found in Metagenics which can be conducive to healthy weight loss. The complete Protandim ingredient list is available on the official website and there is mention of clinical studies. This does not mean clinical studies have been completed directly on Protandim, but we'll see.

Protandim Ingredients

  • Milk Thistle Extract
  • Bacopa Extract
  • Ashwagandha Root
  • Green Tea Extract
  • Turmeric Extract

Features of Protandim

The two ingredients we are most interested in from a diet point of view are green tea and turmeric. Green tea is clinically proven to boost metabolism, even if the caffeine in green tea is taken out of the equation. The EGCG present in green tea boosts metabolism in addition to the added benefits of caffeine. In addition, you can find bacopa extract, which when combined with caffeine, bauhinia purpurea, germanium stem extract, Cirsium oligophyllum, and rauwolscine extract, bacopa extract may be able to increase weight-loss for young and fit men and women. Turmeric recently hit the weight loss market with some pretty impressive preliminary studies. In the studies, participants who took turmeric lost more weight than participants who did not. Additional large-scale studies replicating this effect are needed before the ingredient is considered clinically proven. Although weight loss is an indicator for change in health benefits, one should consider the growth of joint health, immune system support and nutrients infused with vitamins and minerals; Natures Balance is one for consideration. While researching the Protandim Ingredients, we found it was clinically proven to reduce oxidative stress. In other words, the supplement works as an antioxidant, which can impact overall health. Similarly, Catalyst doesn't intentionally promote weight loss, but it does help muscle growth and recovery using amino acids, both conducive to health and wellness for the long-term.

Advantages of Taking Protandim

  • Proven to have antioxidant effects on the body.
  • May reduce oxidative stress by 40%.
  • Clinical studies were completed on Protandim, not just the ingredients.
  • Green tea and turmeric are proven to boost metabolism and weight loss.

Disadvantages of Taking Protandim

  • You have to order through the distributor network.


Protandim is quite an impressive supplement in its given category. Green tea and turmeric may be beneficial for weight loss. There should be no negative interactions between this supplement and other fat burners, but it is best to contact your physician before taking Protandim.

Article Resources
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, Director of Content at Dietspotlight, has researched over 5000 weight-loss programs, pills, shakes and diet plans. Previously, she managed 15 supplement brands, worked with doctors specializing in weight loss and completed coursework in nutrition at Stanford University. full bio.

34 Protandim Reviews

  • Wijendra Don Endersiri

    Why do I feel very weak after taking Protandim for 4 days
    How long must I be taking Protandim before I get the benefit of the gain

    • Montana (Editor)

      Hi Wijendra. Sorry to hear you’ve felt weak, please make sure to see you physician to make sure it’s safe to continue taking this product.

    • Krista H

      Are you taking the nrf2 or the nrf1? They have different benefits. I can help if I know which one you are taking. I’ve taken it for 7 years.

    • Sara D

      Hi Wijendra, Protandim can cause some detox symptoms in the first week or two of use. It’s nothing to worry about 🙂

  • Angelo Vergara

    Hello. Do you also take the new NRF1 along with NRF2? I was told to take twice a day and I just want to know if ti’s ok to take more than the recommended dosage on the bottle.

    • Anna (Editor)

      Hi Angelo. It is recommended that you take the dosage as instructed in the bottle. Please do not take more than the recommended dosage as it can lead to negative side-effects. A product that works with its recommended dosage is Dietspotlight Burn. With two pills a day users have reported results in just 2 weeks. Its so fast and easy. Would you like a sample?

  • bev billingsley

    Can you tell me if ubiquinol can be taken along with protandim. I can’t seem to get an answer from anyone. Thank you.

    • Maribel (Editor)

      Hi Bev! It is best not to combine medications. Either way, please consult with your physician about this.

    • Abby Beitel

      You can ask your pharmacist or any pharmacist .

  • Zara

    I have extremely bad anxiety and a high stress level and this Protandim has helped both those issues. It has also helped with keeping a clear head and not being so tired and drained all the time. I would highly suggest this product to anyone!

    • Angelo S Vergara

      Hi. I have anxiety disorder and have been on Protandim for 4 months. It has helped me. I’ve been taking for the past year.

  • Vern

    Been taking for 3 years. Doctors are impressed with my continued numbers each time they do a blood panel study. I am 74 years old, but my Doctors say my numbers are comparable to a 40 year old patient. My health has improved on many counts, thanks to Protandim.

  • Iwa

    The first 3 weeks I felt the extended energy where I could come home and play with my children.

    • Anna (Editor)

      Hello Iwa. That is wonderful. Family is so important. If energy is important to you, maybe you could take it a step further and sample Dietspotlight Burn? It’s known to boost energy while burning fat. You could lose weight with it too.

  • CS

    Protandim has helped me tremendously….I’ll never be without it. It has helped me sleep better, my mind clearer, etc.

  •  Best supplement I've ever taken for chronic fatigue
    Sara D (Verified User)

    Protandim has gotten rid of the chronic fatigue and pain that I’ve had for several years. I’ve tried all kinds of supplements over the years and nothing has been as effective as Protandim. My whole family takes it now.

  • Julie

    ibe been taking protandim for three months. I have had chronic colitis and irritable bowel syndrome with chronic constipation
    It’s the first time in my life that I have gone to the bathroom every day
    I could right away that my memory was better and my asthma was better
    At first my stomach was upset so I broke in half for one week then increased to one
    No more bloating
    Rarely any discomfort and no constipation
    My doctor was talking surgery but I’m feeling so much better so I’m not
    I also drink alkaline antioxidant water

  • Lori (Verified User)

    Good Morning; I have taken Protandim for about 2 weeks now. I have terrible gas. Does that go away after taking for a longer period of time?

    • Yedy Torres

      Hi Lori,

      One of the side effects caused by Protandim can be gases, please consult your physician if this product is the right one for you.

  • JD

    7 years ago, I viewed an ABC investigative report on Protandim and a PBS Healthquest segment on it which gave me enough information for me to know that I wanted to take it. My family and I have been taking it daily for 7 years. My husband is in medicine and swears by it. He doesn’t tell patients about it because that is improper. Those physicians who say don’t take it, don’t know anything about it, but if you ask them if I can reduce my oxidative stress levels by 40% would it help me? They would not hesitate to say yes. Physicians will agree that oxidative stress & inflammation is at the root cause of most disease and illness.

    That’s why we take it. We want to PREVENT issues.

    It’s simple to take 1 a day right along with our prescription medications (that have been dramatically reduced since we began it). My children (2 of whom are autistic) have seen great benefits in concentration, calm and focus). They are now ages 22, 18, and 16. It is not a “cure all” but a nutritional supplement that stimulates your body’s healing pathways (in layman’s terms).

    It’s a patented herbal formula that seems to work. We will always continue taking it. There’s no doubt we have gotten great benefit.

  • Sherry

    Protandim is wonderful because it reduces oxidative stress (read the research studies on PubMed). You may not necessarily feel better , or worse…. Just know what it does and you will find it useful .

  • GJ Beauchamp

    I’ve have been taking Protandim for 4 years. I was diagnosed with TAYSACHS in 1989. It has changed my life for the better. Praise GOD!

  • Colien

    I have been taking protandim for 4 months and I feel better and can concentrate much better.

  • Oscar

    I’m a true skeptic , but after using product and seeing the results in my mother and in myself we will continue using Protandim and I will recommend to others. I was told about Protandim nrf2 from my best friend, we have been on it for about a month and seeing her improvement is beyond words. Can’t wait to start taking Protandim nrf1 and nrf2, this product is legit, if u are going to try it do it for 30 days at least, I’m on day 26 and feel good.

  •  Yes it works
    Christine (Verified User)

    I’ve just completed my first month of Protandim. At first I was skeptical. The scrubs ave third day I had cramping in the stomach just like I was told might happen. After that and up to now I didn’t motive a lot of difference. I do however know that my skin feels better, softer, less right and dry ave I look a lot younger! My eyes are not sore anymore BUT the biggest thing I noticed I dont take anxiety medicine anymore and I cant even put myself into an anxiety attack!!! Loving it! No more pharmaceutical drugs – it will always Protandim and I’m 54 and feel great!

  •  Love The Product
    Marlene (Verified User)

    Love the product am on my 3rd bottle but have concerns. Why am I putting on weight. I have gained 8lbs. The first bottle I lost about 6 lbs, u now have put all back on and more. Please respond.
    Marlene Krueger

  • Could
    Marjorie La///bell

    could not find price

  • Need information about the ingredients
    Earl D Sorensen (Verified User)

    I didn’t know that the product has caffeine in it. I’m not suppose to use caffeine!! Is their tantium in this product also???

    • Wayne Wood

      It has no caffeine in it. Where did you hear that?

      • Your Name

        Green tea has caffeine.

        • Jane

          It has 4 mg caffeine/dose

          • Pattie

            I read earlier is has 1.8 mg of caffeine which supposedly less than a cup of green tea

    • Abby Beitel

      The very small amount of caffeine is from green tea which normally has half the caffeine of a cup of DECAFFEINATED coffee. It’s miniscule and I wouldn’t let that stop you from taking the best product on the market.

    • Maribel (Editor)

      Hi Earl ! The ingredients in this product are: milk thistle, bacopa extract, ashwagandha, green tea and turmeric. I