Updated: 07/18/2017
By Summer Banks Jul 04, 2017

What is Protandim Nrf2? We’ll find out by taking a closer look at the ingredients, side effects and clinical research. Furthermore, we took into account hundreds of user experiences. Then, we compiled the details to give you the facts you need.

Protandim Readers: Click here to find out why we're giving away samples of our product, Dietspotlight Burn.

What is Protandim?

First off, Protandim is a dietary supplement intended to reduce oxidative stress through “Nrf2 activation.” The ingredients are milk thistle extract, green tea extract, bacopa extract, turmeric extract and ashwagandha root. This product can lower stress levels by 40 percent in only 30 days. This, in turn, helps the body function more efficiently, combats signs of aging and reduces damage from free radicals. You’ll take one capsule per day.

Protandim, made by LifeVantage, hit the market about 2003. You can order the supplement through the distributor network. We like the use of natural ingredients and focus on oxidative stress, but read on…

Customer Reviews – “Positive”

The first thing tackled we’re real user reviews of Protandim. “Customers tend to give honest feedback,” said our Research Editor. “With this one, it seems they’re pleased with the supplement.”

One customer commented, “Ive been taking this for a few years and I like it.”

“It has also helped with keeping a clear head and not being so tired and drained all the time,” said another user.

“Fantastic product,” reported another.

Protandim Ingredients – “Long-Term Success”

According to Protandim reviews, customers notice solid results. We know that results vary, but some users did see positive changes. “Not one who swears by a product. But this time I am…so happy that I gave the product a try and stuck with it,” said a customer.

Another person stated, “Doing what it says less inflammation and pain.”

“I will be ordering again. really works,” commented a consumer.

Our research connects minimal results with long-term success. There’s an issue if users don’t use Protandim as directed, but expect to see positive changes.

The Science – “Valid?”

We wanted to know what is the Nrf2 protein in Protandim ingredients, so we headed straight to the science section of the website. What we expected and what we found was night and day. The company offers several studies explaining the benefits of the product, as well as the formula. The results of the studies were published in journals such as Free Radical Biology & MedicineEnzyme Research, and the American Jouranl of Physiology – Lung Cellular and Molecular Physiology.

The Bottom Line – Does Protandim Work?

After reading through several Protandim studies and testimonials, we’ve made our final verdict on this product. This supplement contains ingredients backed by research, supported by positive reviews and priced inline with its competition. The only concern was a few comments mentioning results. But, after a bit of digging, we found that users didn’t use the supplement for the recommended length of time.

If you’d like to drop those extra pounds, we suggest a product supported by positive user feedback.

Among the best products we’ve seen this year is our product called Dietspotlight Burn. Its formula is a proprietary blend of four ingredients. All clinically-tested with results often found in publications such as The American Journal of Clinical Nutrition.

Also, we’re so confident that you’ll love our supplement that we’re offering customers a Special Trial Offer, which is a good sign.

Previous Protandim Review (Updated April 9, 2014):

Protandim: What You Should Know

At first glance, Protandim does not look like a diet product. The product description talks about reducing oxidative stress, or stress caused by free radicals. This means the supplement contains antioxidants, but there is one proven weight loss ingredient in the formula, so there is some good to be had out of taking this product with an exercise program and healthy meal plan. Pertaining to meal plans, meal supplements with protein, green coffee bean and other ingredients, can be found in Metagenics which can be conducive to healthy weight loss. The complete Protandim ingredient list is available on the official website and there is mention of clinical studies. This does not mean clinical studies have been completed directly on Protandim, but we'll see.

Protandim Ingredients

  • Milk Thistle Extract
  • Bacopa Extract
  • Ashwagandha Root
  • Green Tea Extract
  • Turmeric Extract

Features of Protandim

The two ingredients we are most interested in from a diet point of view are green tea and turmeric. Green tea is clinically proven to boost metabolism, even if the caffeine in green tea is taken out of the equation. The EGCG present in green tea boosts metabolism in addition to the added benefits of caffeine. In addition, you can find bacopa extract, which when combined with caffeine, bauhinia purpurea, germanium stem extract, Cirsium oligophyllum, and rauwolscine extract, bacopa extract may be able to increase weight-loss for young and fit men and women. Turmeric recently hit the weight loss market with some pretty impressive preliminary studies. In the studies, participants who took turmeric lost more weight than participants who did not. Additional large-scale studies replicating this effect are needed before the ingredient is considered clinically proven. Although weight loss is an indicator for change in health benefits, one should consider the growth of joint health, immune system support and nutrients infused with vitamins and minerals; Natures Balance is one for consideration. While researching the Protandim Ingredients, we found it was clinically proven to reduce oxidative stress. In other words, the supplement works as an antioxidant, which can impact overall health. Similarly, Catalyst doesn't intentionally promote weight loss, but it does help muscle growth and recovery using amino acids, both conducive to health and wellness for the long-term.

Advantages of Taking Protandim

  • Proven to have antioxidant effects on the body.
  • May reduce oxidative stress by 40%.
  • Clinical studies were completed on Protandim, not just the ingredients.
  • Green tea and turmeric are proven to boost metabolism and weight loss.

Disadvantages of Taking Protandim

  • You have to order through the distributor network.


Protandim is quite an impressive supplement in its given category. Green tea and turmeric may be beneficial for weight loss. There should be no negative interactions between this supplement and other fat burners, but it is best to contact your physician before taking Protandim.

Protandim is a supplement using nutrigenomics to activate the Nrf2 pathway.

Protandim Ingredients and Supplement Facts

Serving Size: 1 Caplet
Serving Per Container: 30
Amount per Serving% DV
Milk thistle225mg*
Green tea75mg*

Other Ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Silica, Modified Cellulose, Stearic Acid, Magnesium Stearate, Maltodextrin, Medium Chain Triglycerides

We often come across a supplement like Protandim that needs a little closer attention. This time around we looked hard at Protandim ingredients. Additionally, we checked to see if there’s an issue with side effects and research supporting the formula. We also took into account what hundreds of users had to say. Then, we compiled the facts to give you the details you need.

What are Protandim Ingredients?

First off, Protandim ingredients are milk thistle, ashwagandha, bacopa, green tea and turmeric. The supplement reduces oxidative stress; the imbalance between the bodies ability to counteract the effects of free radicals and their production. You’ll take just one capsule per day.

The supplement, made by LifeVantage, does not use synthetic ingredients, impressive. The official website and outside retail sites sell the supplement. It’s good that there are clinical studies and a few positive reviews, but read on…

Clinical Support – “More Than One Study”

Our first thing tacked was the research supporting Protandim ingredients. “When it comes to a supplement, customers deserve the facts,” said our Research Editor. “With this one, we found more than enough solid science supporting it.”

According to Molecular Aspects of Medicine, “Pathway analysis of results shows significant modulation by Protandim of pathways.” [1]

Another study published in the Journal of Dietary Supplements found that “Protandim…was safe and well tolerated. A 48% average decrease in plasma TBARS (thiobarbituric acid-reactive substances) was seen.” [2]

Other Ingredients – “Offering More Support?”

Protandim nrf2 Synergizer is what we hear the most about, but what about the other ingredients. The supplement also includes milk thistle [3], bacopa [4], ashwagandha [5], green tea [6] and turmeric [7].

With each ingredient, you’ll notice it offers antioxidant support or boosts in metabolic rate.

So what do customers have to say about Protandim ingredients?

“I like the results I am having with these,” commented a user.

“I have extremely bad anxiety and a high stress level and this Protandim has helped both those issues,” stated a customer.

“Protandim NRF2 for about 9 months, and NRF1 for about 5 months now…could not believe the result,” offered another.

The Science – “Studies Backing the Claims”

Science is what Protandim does best. The company provides a section dedicated to Protandim ingredients. Unlike some companies that tell you that there’s research backing a formula; the company offers evidence. Studies go into depth about the benefits of supplement [8], the nrf2 protein [9] and its benefits toward oxidative stress [10], as well as its antioxidant properties [11].

The Bottom Line – Does Protandim Ingredients Work?

Protandim ingredients offered a good read and the information we found made it easy to come to a conclusion. We like that the formula is described online and that several clinical studies have been performed on the supplement. With the research alone, we feel we can stand behind this one.

If you have that push to lose weight, we suggest trying out a product that offers a list of proven ingredients that don’t cause side effects.

Among the best products we’ve seen this year is our product called Dietspotlight Burn. It contains a four-ingredient proprietary blend. All clinically-tested, with results often found in publications such as The American Journal of Clinical Nutrition.

Also, we’re offering customers a Special Trial Offer, which is a good sign you’ll love our supplement.

Protandim Side Effects:

Protandim is a widely-used product for oxidative stress. Most experiences are free of negative side effects.

Stomach Pain

Stomach pain can make it hard to get through the day. In milder cases, it’s a general unease in your stomach area. When it becomes severe, stomach pain can be an acute stabbing sensation. Often, stomach pain is accompanied by symptoms like gas, bloating, nausea, fever, and sweating.

What causes stomach pain?

Stomach pain has many possible causes. Many cases stem from indigestion and food intolerance. It’s also possible to experience abdominal pain as a result of pelvic inflammatory disease or stomach virus. [1]


A bad case of the “the runs” can be extremely uncomfortable. Having to go to the bathroom every few minutes to pass a watery stool leaves you exhausted. Your rectum is prone to burning and rash. Also, because diarrhea expels so much liquid, you’re at risk of dehydration. If you suffer from diarrhea, be sure to drink plenty of fluids.

What causes diarrhea?

Most cases of diarrhea are the direct result of stomach viruses and bacteria. These infect your body when you eat something spoiled. It may also be that your body has an intolerance or allergy to something you ate. Or you may be suffering from irritable bowel syndrome.


Vomiting is often accompanied and preceded by nausea and stomach ache. It can consist of various sessions and come and go throughout the day. Vomiting leaves you with a burning sensation in your throat. It can also lead to dehydration and malnutrition. Prolonged vomiting is cause for concern and may require the attention of a doctor.

What causes vomiting?

One of the top causes of vomiting is food poisoning. Be careful with what you consume. Always make sure food isn’t expired and that it doesn’t contain ingredients to which you’re allergic. Vomiting can also be a result of conditions like migraine, appendicitis, concussion, hyperthyroidism, and fever. [2]


A headache can be very stressful. Depending on the severity of the pain, you may feel dizzy and weak. Headaches make it hard to focus and concentrate.

What causes headaches?

Most headaches are not cause for concern. They’re provoked by stress, hunger, or tiredness. They go away after a few hours with rest. Some headaches may be indicative of an underlying illness. Glauccoma, high blood pressure, and stroke are known to cause headaches. Seek a doctor’s help if you experience regular headaches.

Protandim is safe to use. Everyone reacts differently to supplements. Talk with your doctor about how Protandim ingredients may influence your health.


Protandim Questions & Answers:

We narrowed down hundreds of user reviews about Protandim and created this helpful FAQ.

What are the side effects of Lifevantage Protandim?

Some potential Protandim side effects we’re mild, especially if they didn’t follow the directions.

What are the ingredients in Protandim?

Protandim ingredients include milk thistle [1], bacopa extract, ashwagandha, green tea and turmeric.

Does Protandim work?

There a several studies listed on the Protandim website. We noticed several dealt with oxidative stress, as well as the antioxidant effect of Protandim ingredients [2]. Based on research and customer testimonials, there’s a chance you’ll see results.

How much does Protandim cost?

Protandim costs $50 for a 30-day supply. If you sign up for the auto-ship, the cost is $40.

How should I take Protandim?

You should take one Protandim capsule per day. One bottle lasts a month.

Can I take Protandim if I have a health condition?

Women who are pregnant or nursing, those with health conditions, anyone under 18 years of age or people taking prescription medications should contact a healthcare professional prior to using a dietary supplement of any kind.

What do users like about Protandim?

Users liked the results experienced after taking Protandim.

What do users NOT like about Protandim?

Some users didn’t like not finding Protandim sooner.

How do I contact the Protandim customer service department?

You can connect with the Protandim customer service department by calling 1-866-460-7241, emailing a representative at customerservice@lifevantage.com or by mailing correspondence to LifeVantage Corporation 9785 S. Monroe St. Suite 300 Sandy, UT 84070.

Can I contact Protandim through social media?

Yes, you can contact them on their Facebook or Twitter.

Does Protandim contain caffeine?

No, Protandim doesn’t contain caffeine, but the green tea could possibly act as a stimulant.

What is NrF2 in Protandim?

NrF2 in Protandim is a protein supposedly stimulating enzymes to reduce the effects of free radicals.

Does Protandim come with a guarantee?

Protandim does come with a guarantee. You have 30 days to return the supplement for a full refund.

Do you know of any special deals or discounts on Protandim?

There’s no mention of deals or discounts on the official Protandim website, but you can reach out to one of the distributors for additional details. Our readers have been going wild over the last few months taking advantage of Dietspotlight Burn’s Special Trial Offer, which is simply the cost of shipping and handling. Click above to give it a try.

Protandim Scientific Abstracts:

Milk Thistle

There was no evidence found regarding the carcinogenic activity of milk thistle within female or male rats given 12,500, 25,000, or 50,000 ppm. There were elevated incidences of clear and mixed cell foci within the liver of those exposed to milk thistle, as well as the reduction in body weight in female and male rats. Reductions in incidences of mammary gland neoplasms were noticed in female and male groups exposed to milk thistle, and there were decreased incidences of hepatocellular neoplasms within female and male groups exposed to milk thistle. [1]


Standardized Bacopa monnieri extract greatly decreased subtest scores of symptoms of ADHD, with the exception of social issues. Restlessness scores decreased in 93% and improvement in self-control was noticed in 89% of the children. AD (attention deficit) symptoms were decreased by 85%. Learning issues, impulsivity, and psychiatric issues were decreased as well for 78%, 67%, and 52% of the children. 74% of children showed up to a 20% decrease, while 26% displayed between 21% and 50% decrease in total subtests. In conclusion, standard extract of Bacopa monnieri was discovered to be beneficial in the alleviation of ADHD symptoms as well as being well tolerated by the children subjects. [2]


The group given ashwagandha showed a substantially greater elevation in muscle strength on the bench press than the placebo subjects (Placebo: 26.4 kg, 95 % confidence interval, 19.5, 33.3 versus Ashwagandha: 46.0 kg, 95 % confidence interval 36.6, 55.5; p = 0.001). They also experienced greater muscle strength on the leg-extension exercise (Placebo: 9.8 kg, 95 % confidence interval, 7.2,12.3 versus Ashwagandha: 14.5 kg, 95 % confidence interval, 10.8,18.2; p = 0.04) and substantially greater muscle size increase of the chest (Placebo: 1.4 cm, 95 % confidence interval, 0.8, 2.0 versus Ashwagandha: 3.3 cm, 95 % confidence interval, 2.6, 4.1; p < 0.001) and arms (Placebo: 5.3 cm2, 95 % confidence interval, 3.3,7.2 versus Ashwagandha: 8.6 cm2, 95 % confidence interval, 6.9,10.8; p = 0.01). In comparison to those taking placebo, the individuals taking ashwagandha had experienced more of a decrease of exercise-induced muscle damage which was discovered due to the stabilization of serum creatine kinase (Placebo: 1307.5 U/L, 95 % confidence interval, 1202.8, 1412.1, versus Ashwagandha: 1462.6 U/L, 95 % confidence interval, 1366.2, 1559.1; p = 0.03) substantially more testosterone (Placebo: 18.0 ng/dL, 95 % confidence interval, -15.8, 51.8 versus Ashwagandha: 96.2 ng/dL, 95 % confidence interval, 54.7, 137.5; p = 0.004) and a greater reduction in percentage of body fat (Placebo: 1.5 %, 95 % confidence interval, 0.4 %, 2.6 % versus Ashwagandha: 3.5 %, 95 % confidence interval, 2.0 %, 4.9 %; p = 0.03). In conclusion, the study suggests that ashwagandha supplementation is linked with substantial elevations in muscle mass and strength and indicates that ashwagandha supplementation could be beneficial along with a resistance training program. [3]

Learn More About Dietspotlight Burn »
Summer Banks Dietspotlight Author
About the Author:

Summer Banks, a content strategist at Dietspotlight, has researched over 5000 products in the past 10 years. She has years of nursing training, experience as a manager responsible for 15 supplement brands, and completed coursework on Food and Nutrition from Stanford University. full bio.

Rating: 2.9. From 40 votes.
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Leave a comment or review

Wijendra Don Endersiri

Why do I feel very weak after taking Protandim for 4 days
How long must I be taking Protandim before I get the benefit of the gain

Montana (Editor)

Hi Wijendra. Sorry to hear you’ve felt weak, please make sure to see you physician to make sure it’s safe to continue taking this product.

Angelo Vergara

Hello. Do you also take the new NRF1 along with NRF2? I was told to take twice a day and I just want to know if ti’s ok to take more than the recommended dosage on the bottle.


That’s up to you.

Victoria (Editor)

Hi Angelo. It is recommended that you take the dosage as instructed in the bottle. Please do not take more than the recommended dosage as it can lead to negative side-effects.

bev billingsley

Can you tell me if ubiquinol can be taken along with protandim. I can’t seem to get an answer from anyone. Thank you.

Abby Beitel

You can ask your pharmacist or any pharmacist .

Maribel (Editor)

Hi Bev! It is best not to combine medications. Either way, please consult with your physician about this.


I have extremely bad anxiety and a high stress level and this Protandim has helped both those issues. It has also helped with keeping a clear head and not being so tired and drained all the time. I would highly suggest this product to anyone!

Angelo S Vergara

Hi. I have anxiety disorder and have been on Protandim for 4 months. It has helped me. I’ve been taking for the past year.


Been taking for 3 years. Doctors are impressed with my continued numbers each time they do a blood panel study. I am 74 years old, but my Doctors say my numbers are comparable to a 40 year old patient. My health has improved on many counts, thanks to Protandim.


The first 3 weeks I felt the extended energy where I could come home and play with my children.

Victoria (Editor)

Hello. All users are different and can experience different results.


Protandim has helped me tremendously….I’ll never be without it. It has helped me sleep better, my mind clearer, etc.


ibe been taking protandim for three months. I have had chronic colitis and irritable bowel syndrome with chronic constipation
It’s the first time in my life that I have gone to the bathroom every day
I could right away that my memory was better and my asthma was better
At first my stomach was upset so I broke in half for one week then increased to one
No more bloating
Rarely any discomfort and no constipation
My doctor was talking surgery but I’m feeling so much better so I’m not
I also drink alkaline antioxidant water


7 years ago, I viewed an ABC investigative report on Protandim and a PBS Healthquest segment on it which gave me enough information for me to know that I wanted to take it. My family and I have been taking it daily for 7 years. My husband is in medicine and swears by it. He doesn’t tell patients about it because that is improper. Those physicians who say don’t take it, don’t know anything about it, but if you ask them if I can reduce my oxidative stress levels by 40% would it help me? They would not hesitate to say yes. Physicians will agree that oxidative stress & inflammation is at the root cause of most disease and illness.

That’s why we take it. We want to PREVENT issues.

It’s simple to take 1 a day right along with our prescription medications (that have been dramatically reduced since we began it). My children (2 of whom are autistic) have seen great benefits in concentration, calm and focus). They are now ages 22, 18, and 16. It is not a “cure all” but a nutritional supplement that stimulates your body’s healing pathways (in layman’s terms).

It’s a patented herbal formula that seems to work. We will always continue taking it. There’s no doubt we have gotten great benefit.


Protandim is wonderful because it reduces oxidative stress (read the research studies on PubMed). You may not necessarily feel better , or worse…. Just know what it does and you will find it useful .

GJ Beauchamp

I’ve have been taking Protandim for 4 years. I was diagnosed with TAYSACHS in 1989. It has changed my life for the better. Praise GOD!


I have been taking protandim for 4 months and I feel better and can concentrate much better.

Victoria (Editor)

Hi! For detailed product and usage instructions, please refer to the Protandim official website for more information.


I’m a true skeptic , but after using product and seeing the results in my mother and in myself we will continue using Protandim and I will recommend to others. I was told about Protandim nrf2 from my best friend, we have been on it for about a month and seeing her improvement is beyond words. Can’t wait to start taking Protandim nrf1 and nrf2, this product is legit, if u are going to try it do it for 30 days at least, I’m on day 26 and feel good.

  Love The Product
Marlene (Verified User)

Love the product am on my 3rd bottle but have concerns. Why am I putting on weight. I have gained 8lbs. The first bottle I lost about 6 lbs, u now have put all back on and more. Please respond.
Marlene Krueger

Marjorie La///bell

could not find price

  Need information about the ingredients
Earl D Sorensen (Verified User)

I didn’t know that the product has caffeine in it. I’m not suppose to use caffeine!! Is their tantium in this product also???

Maribel (Editor)

Hi Earl ! The ingredients in this product are: milk thistle, bacopa extract, ashwagandha, green tea and turmeric. I

Abby Beitel

The very small amount of caffeine is from green tea which normally has half the caffeine of a cup of DECAFFEINATED coffee. It’s miniscule and I wouldn’t let that stop you from taking the best product on the market.

Wayne Wood

It has no caffeine in it. Where did you hear that?


Green tea has caffeine.


It has 4 mg caffeine/dose